SENP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.39135542
2piRNA metabolic process (GO:0034587)5.06572599
3acrosome assembly (GO:0001675)4.98448190
4male meiosis (GO:0007140)4.43119985
5fusion of sperm to egg plasma membrane (GO:0007342)4.38077105
6synaptonemal complex organization (GO:0070193)4.31247927
7sperm motility (GO:0030317)4.23625168
8synaptonemal complex assembly (GO:0007130)4.17852069
9regulation of gene silencing by RNA (GO:0060966)4.13636961
10regulation of posttranscriptional gene silencing (GO:0060147)4.13636961
11regulation of gene silencing by miRNA (GO:0060964)4.13636961
12synapsis (GO:0007129)4.10929298
13regulation of centriole replication (GO:0046599)4.02821046
14nuclear pore complex assembly (GO:0051292)3.94411604
15sulfation (GO:0051923)3.90907611
16regulation of translational termination (GO:0006449)3.87346856
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.82921381
18nuclear pore organization (GO:0006999)3.82745304
19resolution of meiotic recombination intermediates (GO:0000712)3.80944468
20synaptic vesicle maturation (GO:0016188)3.80892146
21* regulation of DNA endoreduplication (GO:0032875)3.80597373
22sperm-egg recognition (GO:0035036)3.78973920
23negative regulation of organelle assembly (GO:1902116)3.69173702
24acrosome reaction (GO:0007340)3.68248443
25spermatid development (GO:0007286)3.64993728
26cell-cell recognition (GO:0009988)3.58633591
27monoubiquitinated protein deubiquitination (GO:0035520)3.57796336
28binding of sperm to zona pellucida (GO:0007339)3.57719742
29plasma membrane fusion (GO:0045026)3.56278683
30regulation of clathrin-mediated endocytosis (GO:2000369)3.53449942
31axonemal dynein complex assembly (GO:0070286)3.41449275
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.41390656
33motile cilium assembly (GO:0044458)3.37651524
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.37551323
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37551323
36mitotic sister chromatid cohesion (GO:0007064)3.36094667
37gene silencing by RNA (GO:0031047)3.35047823
38regulation of protein polyubiquitination (GO:1902914)3.34247067
39negative regulation of DNA-dependent DNA replication (GO:2000104)3.31643836
40negative regulation of inclusion body assembly (GO:0090084)3.31404123
41locomotory exploration behavior (GO:0035641)3.30812613
42negative regulation of cell killing (GO:0031342)3.30245578
43negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30245578
44water-soluble vitamin biosynthetic process (GO:0042364)3.29686020
45multicellular organism reproduction (GO:0032504)3.29673785
46chromatin remodeling at centromere (GO:0031055)3.27738174
47CENP-A containing nucleosome assembly (GO:0034080)3.27192669
48pore complex assembly (GO:0046931)3.20560171
49histone exchange (GO:0043486)3.20537673
50behavioral response to nicotine (GO:0035095)3.17989392
51regulation of NFAT protein import into nucleus (GO:0051532)3.17782589
52glutamate secretion (GO:0014047)3.14454037
53NLS-bearing protein import into nucleus (GO:0006607)3.12770445
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12043347
55peptidyl-lysine dimethylation (GO:0018027)3.10804164
56otic vesicle formation (GO:0030916)3.05179511
57DNA double-strand break processing (GO:0000729)3.04437021
58regulation of hippo signaling (GO:0035330)3.03751622
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01454493
60regulation of mitotic spindle checkpoint (GO:1903504)3.01454493
61DNA methylation involved in gamete generation (GO:0043046)2.98736633
62pre-miRNA processing (GO:0031054)2.97115082
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94515266
64regulation of nuclear cell cycle DNA replication (GO:0033262)2.93353062
65vesicle transport along microtubule (GO:0047496)2.89295769
66regulation of glomerulus development (GO:0090192)2.88778406
67cell wall macromolecule catabolic process (GO:0016998)2.86809161
68cell wall macromolecule metabolic process (GO:0044036)2.86809161
69meiotic chromosome segregation (GO:0045132)2.84479795
70epithelial cilium movement (GO:0003351)2.83638325
71regulation of ARF protein signal transduction (GO:0032012)2.81328443
72synaptic vesicle exocytosis (GO:0016079)2.80389940
73positive regulation of cAMP-mediated signaling (GO:0043950)2.79562404
74replication fork processing (GO:0031297)2.79189580
75reproduction (GO:0000003)2.78707709
76double-strand break repair via homologous recombination (GO:0000724)2.78050516
77telomere maintenance via telomerase (GO:0007004)2.77126839
78DNA replication checkpoint (GO:0000076)2.77019366
79positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76998228
80regulation of synaptic vesicle exocytosis (GO:2000300)2.76245040
81response to UV-C (GO:0010225)2.76042454
82recombinational repair (GO:0000725)2.75778508
83peptidyl-threonine phosphorylation (GO:0018107)2.74597063
84regulation of RNA export from nucleus (GO:0046831)2.73773785
85positive regulation of meiosis (GO:0045836)2.73239824
86protein K6-linked ubiquitination (GO:0085020)2.70911624
87regulation of meiosis I (GO:0060631)2.70833539
88cell proliferation in forebrain (GO:0021846)2.69542299
89meiotic nuclear division (GO:0007126)2.68592464
90regulation of nucleobase-containing compound transport (GO:0032239)2.68233254
91gene silencing (GO:0016458)2.67743686
92regulation of mesoderm development (GO:2000380)2.66756137
93regulation of cell proliferation involved in kidney development (GO:1901722)2.66338124
94layer formation in cerebral cortex (GO:0021819)2.66096737
95magnesium ion transport (GO:0015693)2.65598410
96peptidyl-threonine modification (GO:0018210)2.65254549
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.64503362
98mitochondrial respiratory chain complex I assembly (GO:0032981)2.64503362
99NADH dehydrogenase complex assembly (GO:0010257)2.64503362
100calcium ion-dependent exocytosis (GO:0017156)2.64397579
101proline transport (GO:0015824)2.63166326
102clathrin coat assembly (GO:0048268)2.62452780
103limb bud formation (GO:0060174)2.62064016
104histone H3-K9 demethylation (GO:0033169)2.61678164
105spindle assembly involved in mitosis (GO:0090307)2.61424889
106negative regulation of transcription regulatory region DNA binding (GO:2000678)2.60662009
107male meiosis I (GO:0007141)2.60429816
108chromosome organization involved in meiosis (GO:0070192)2.60115292
109positive regulation of meiotic cell cycle (GO:0051446)2.59618952
110mitotic metaphase plate congression (GO:0007080)2.58825087
111gonadal mesoderm development (GO:0007506)2.57927914
112heterochromatin organization (GO:0070828)2.57586723
113regulation of synaptic vesicle transport (GO:1902803)2.56585964
114synaptic vesicle endocytosis (GO:0048488)2.55407939
115regulation of histone H3-K9 methylation (GO:0051570)2.52510548
116negative regulation of gene silencing (GO:0060969)2.52411642
117regulation of cilium movement (GO:0003352)2.51147340
118positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.50748095
119presynaptic membrane assembly (GO:0097105)2.50201803
120regulation of long-term neuronal synaptic plasticity (GO:0048169)2.49773895
121kynurenine metabolic process (GO:0070189)2.48641064
122sister chromatid cohesion (GO:0007062)2.46816597
123cilium movement (GO:0003341)2.45632656
124cellular response to ATP (GO:0071318)2.45317618
125negative regulation of histone methylation (GO:0031061)2.44625178
126seminiferous tubule development (GO:0072520)2.44524394
127protein K11-linked deubiquitination (GO:0035871)2.43898691
128ventricular system development (GO:0021591)2.43775036
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43712426
130somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.43640131
131somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.43640131
132isotype switching (GO:0045190)2.43640131
133DNA replication-independent nucleosome organization (GO:0034724)2.42988496
134DNA replication-independent nucleosome assembly (GO:0006336)2.42988496
135positive regulation of synapse maturation (GO:0090129)2.42917191
136regulation of helicase activity (GO:0051095)2.42670628
137germ cell development (GO:0007281)2.42233383
138cellular process involved in reproduction in multicellular organism (GO:0022412)2.41906342
139regulation of translational fidelity (GO:0006450)2.40193861
140mitochondrial respiratory chain complex assembly (GO:0033108)2.40165500
141regulation of centrosome cycle (GO:0046605)2.40111506
142RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.39012365
143cerebellar Purkinje cell differentiation (GO:0021702)2.38934431
144ionotropic glutamate receptor signaling pathway (GO:0035235)2.38818887
145meiosis I (GO:0007127)2.38397893
146mRNA stabilization (GO:0048255)2.37718471
147RNA stabilization (GO:0043489)2.37718471
148regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.37296192
149regulation of ARF GTPase activity (GO:0032312)2.37199993
150protein complex biogenesis (GO:0070271)2.36894735
151ncRNA catabolic process (GO:0034661)2.36880958
152cellular potassium ion homeostasis (GO:0030007)2.36752141
153metaphase plate congression (GO:0051310)2.36452318
154pseudouridine synthesis (GO:0001522)2.36228192
155regulation of Rac protein signal transduction (GO:0035020)2.36155522
156parturition (GO:0007567)2.35888905
157somatic recombination of immunoglobulin gene segments (GO:0016447)2.35689444
158somatic diversification of immunoglobulins (GO:0016445)2.35309423
159protein prenylation (GO:0018342)2.34861909
160prenylation (GO:0097354)2.34861909
161neurotransmitter secretion (GO:0007269)2.34380047
162DNA replication-dependent nucleosome organization (GO:0034723)2.34041458
163DNA replication-dependent nucleosome assembly (GO:0006335)2.34041458
164nuclear envelope disassembly (GO:0051081)2.33923496
165membrane disassembly (GO:0030397)2.33923496
166regulation of glutamate receptor signaling pathway (GO:1900449)2.33653520
167regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.33424002
168kinetochore organization (GO:0051383)2.32680028
169protein localization to synapse (GO:0035418)2.32129480
170regulation of centrosome duplication (GO:0010824)2.32046374
171meiotic cell cycle process (GO:1903046)2.31106849
172somite development (GO:0061053)2.31068858
173microtubule anchoring (GO:0034453)2.30849514
174anterior/posterior axis specification, embryo (GO:0008595)2.30521950
175positive regulation of mitotic sister chromatid separation (GO:1901970)2.29761010
176positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.29761010
177positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.29761010
178establishment of protein localization to Golgi (GO:0072600)2.29577182
179regulation of neuronal synaptic plasticity (GO:0048168)2.29342593
180microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.29235130
181DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.29213310
182exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.29105262
183protein polyglutamylation (GO:0018095)2.28956119
184negative regulation of systemic arterial blood pressure (GO:0003085)2.26541217
185rRNA catabolic process (GO:0016075)2.26538944
186positive regulation of mRNA processing (GO:0050685)2.24847025
187protein localization to kinetochore (GO:0034501)2.24397634
188negative regulation of appetite (GO:0032099)2.24132046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.49623186
2E2F7_22180533_ChIP-Seq_HELA_Human4.60001521
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.82253005
4EZH2_22144423_ChIP-Seq_EOC_Human3.65125241
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.48458733
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.25235514
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.08407069
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.75829656
9EWS_26573619_Chip-Seq_HEK293_Human2.61314607
10GBX2_23144817_ChIP-Seq_PC3_Human2.53031305
11FUS_26573619_Chip-Seq_HEK293_Human2.37763942
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36838782
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.35466205
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29435707
15VDR_22108803_ChIP-Seq_LS180_Human2.26118900
16* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26100632
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.23812809
18* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.18116257
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16475497
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.15390807
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.06797599
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.06446677
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04910208
24ELK1_19687146_ChIP-ChIP_HELA_Human2.04673422
25* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04387309
26TAF15_26573619_Chip-Seq_HEK293_Human2.01868650
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00922088
28MYC_22102868_ChIP-Seq_BL_Human1.97822176
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94312119
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.91644777
31TCF7_22412390_ChIP-Seq_EML_Mouse1.88395754
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85306082
33PKCTHETA_26484144_Chip-Seq_BREAST_Human1.84135901
34TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.83455246
35KDM2B_26808549_Chip-Seq_DND41_Human1.81670489
36* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.79547808
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.78745003
38P300_19829295_ChIP-Seq_ESCs_Human1.78262212
39* IGF1R_20145208_ChIP-Seq_DFB_Human1.75825949
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.75237537
41FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71577080
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70994408
43ELK4_26923725_Chip-Seq_MESODERM_Mouse1.69423229
44* REST_21632747_ChIP-Seq_MESCs_Mouse1.68904008
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67888373
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63769380
47ER_23166858_ChIP-Seq_MCF-7_Human1.62536685
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62079103
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60741185
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59568929
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54589078
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53443034
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53274025
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52912679
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49588992
56MYC_18940864_ChIP-ChIP_HL60_Human1.48923141
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48133161
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46528239
59ZNF274_21170338_ChIP-Seq_K562_Hela1.45546687
60IRF1_19129219_ChIP-ChIP_H3396_Human1.43789446
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41962877
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.40942685
63SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40232620
64* NANOG_16153702_ChIP-ChIP_HESCs_Human1.38610278
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37911323
66SPI1_23127762_ChIP-Seq_K562_Human1.37532765
67STAT3_23295773_ChIP-Seq_U87_Human1.37160636
68IRF8_21731497_ChIP-ChIP_J774_Mouse1.36875282
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36205368
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35658321
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32608589
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32091271
73BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31683561
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.31448427
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31147100
76KDM2B_26808549_Chip-Seq_K562_Human1.30248101
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29883735
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29679576
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28402644
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.27686261
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27550436
82* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27367084
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26295535
84ZNF263_19887448_ChIP-Seq_K562_Human1.24996800
85* SOX2_16153702_ChIP-ChIP_HESCs_Human1.24963526
86CBP_20019798_ChIP-Seq_JUKART_Human1.24900983
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24900983
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24818479
89SMAD4_21799915_ChIP-Seq_A2780_Human1.24548736
90BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24495345
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24059903
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23779152
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22543921
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22530909
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21944950
96DROSHA_22980978_ChIP-Seq_HELA_Human1.21867155
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20689587
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20326418
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19756232
100* VDR_23849224_ChIP-Seq_CD4+_Human1.18663309
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.17880961
102* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17777017
103ETS1_20019798_ChIP-Seq_JURKAT_Human1.17016792
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.16524529
105RNF2_27304074_Chip-Seq_NSC_Mouse1.16457550
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16445949
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15420175
108NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15352254
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.14610289
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14326083
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13502115
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.12738012
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12599286
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12577064
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12373804
116* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12000697
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09743939
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.08291629
119KDM2B_26808549_Chip-Seq_JURKAT_Human1.08075240
120AR_25329375_ChIP-Seq_VCAP_Human1.07534323
121SOX9_26525672_Chip-Seq_HEART_Mouse1.07289248
122NANOG_18555785_Chip-Seq_ESCs_Mouse1.06885854
123FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05337056
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04950939
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04348150
126FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04105513
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03963557
128E2F1_21310950_ChIP-Seq_MCF-7_Human1.03918536
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03413946
130* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02963768
131BCAT_22108803_ChIP-Seq_LS180_Human1.02927192
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02749460
133MYB_26560356_Chip-Seq_TH1_Human1.02492202
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02324463
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02324463
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02210069
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02059946
138KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00662461
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00547037
140SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99582724
141FOXP3_21729870_ChIP-Seq_TREG_Human0.99158563
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99008172
143MYB_26560356_Chip-Seq_TH2_Human0.98375885
144TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98120348
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97323794
146MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97025711
147E2F1_18555785_Chip-Seq_ESCs_Mouse0.96668778
148JUN_21703547_ChIP-Seq_K562_Human0.95957875
149TP53_22573176_ChIP-Seq_HFKS_Human0.95761601
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95331816
151AR_21572438_ChIP-Seq_LNCaP_Human0.95090336
152MYC_18555785_ChIP-Seq_MESCs_Mouse0.94878946
153TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94742467
154P53_22387025_ChIP-Seq_ESCs_Mouse0.94570806
155RUNX1_22412390_ChIP-Seq_EML_Mouse0.94128864
156EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93650074
157* REST_18959480_ChIP-ChIP_MESCs_Mouse0.92586750
158UTX_26944678_Chip-Seq_JUKART_Human0.92314869
159P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90869984
160SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90468814
161IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90181620
162SMAD3_21741376_ChIP-Seq_ESCs_Human0.88535548
163VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87726733
164TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87167951
165GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87012971
166GATA3_27048872_Chip-Seq_THYMUS_Human0.86164870
167RUNX_20019798_ChIP-Seq_JUKART_Human0.85625737
168GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.83174092
169TP53_22127205_ChIP-Seq_IMR90_Human0.83007608
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82622211
171E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82565959
172WDR5_24793694_ChIP-Seq_LNCAP_Human0.82554426
173DPY_21335234_ChIP-Seq_ESCs_Mouse0.81468934
174RUNX1_27514584_Chip-Seq_MCF-7_Human0.80950480
175TP53_16413492_ChIP-PET_HCT116_Human0.79042843
176FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78592949
177MAF_26560356_Chip-Seq_TH1_Human0.78501554
178TCF4_23295773_ChIP-Seq_U87_Human0.77856847
179MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.77839281
180NCOR1_26117541_ChIP-Seq_K562_Human0.77511464
181KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.77326875
182OCT4_19829295_ChIP-Seq_ESCs_Human0.77183349
183GATA3_26560356_Chip-Seq_TH1_Human0.76739888
184SMRT_27268052_Chip-Seq_Bcells_Human0.76035689
185PU_27001747_Chip-Seq_BMDM_Mouse0.73445178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.33464932
2MP0004859_abnormal_synaptic_plasticity4.85135006
3MP0000569_abnormal_digit_pigmentation4.52980980
4MP0008877_abnormal_DNA_methylation4.02523292
5MP0010234_abnormal_vibrissa_follicle2.96908231
6MP0003787_abnormal_imprinting2.75568494
7MP0010307_abnormal_tumor_latency2.49745603
8MP0005076_abnormal_cell_differentiation2.49198631
9MP0006292_abnormal_olfactory_placode2.38563308
10MP0003698_abnormal_male_reproductive2.37257808
11MP0003635_abnormal_synaptic_transmissio2.33614282
12MP0009046_muscle_twitch2.23768389
13MP0003303_peritoneal_inflammation2.20418959
14MP0001929_abnormal_gametogenesis2.19745323
15MP0003172_abnormal_lysosome_physiology2.05288493
16MP0003646_muscle_fatigue2.03269026
17MP0004885_abnormal_endolymph2.00702376
18MP0002063_abnormal_learning/memory/cond1.94483474
19MP0005623_abnormal_meninges_morphology1.90841775
20MP0003937_abnormal_limbs/digits/tail_de1.87512849
21MP0002102_abnormal_ear_morphology1.84993164
22MP0002653_abnormal_ependyma_morphology1.83685737
23MP0003123_paternal_imprinting1.73886032
24MP0010352_gastrointestinal_tract_polyps1.72305003
25MP0000631_abnormal_neuroendocrine_gland1.72145971
26MP0003111_abnormal_nucleus_morphology1.70992826
27MP0003718_maternal_effect1.70464734
28MP0003567_abnormal_fetal_cardiomyocyte1.69862963
29MP0005389_reproductive_system_phenotype1.67189666
30MP0004270_analgesia1.66045962
31MP0002064_seizures1.61807847
32MP0004134_abnormal_chest_morphology1.60358643
33MP0001188_hyperpigmentation1.59441748
34MP0004145_abnormal_muscle_electrophysio1.57867494
35MP0009745_abnormal_behavioral_response1.57570911
36MP0001485_abnormal_pinna_reflex1.57316644
37MP0006072_abnormal_retinal_apoptosis1.56468637
38MP0002210_abnormal_sex_determination1.56104157
39MP0003119_abnormal_digestive_system1.52281789
40MP0003941_abnormal_skin_development1.51783612
41MP0009697_abnormal_copulation1.51639465
42MP0004811_abnormal_neuron_physiology1.51375928
43MP0010094_abnormal_chromosome_stability1.49057601
44MP0005646_abnormal_pituitary_gland1.48173913
45MP0004808_abnormal_hematopoietic_stem1.47134028
46MP0000049_abnormal_middle_ear1.46644611
47MP0003705_abnormal_hypodermis_morpholog1.44346331
48MP0009278_abnormal_bone_marrow1.43688720
49MP0005551_abnormal_eye_electrophysiolog1.43131023
50MP0002572_abnormal_emotion/affect_behav1.40981308
51MP0001145_abnormal_male_reproductive1.40290782
52MP0001529_abnormal_vocalization1.39342512
53MP0002161_abnormal_fertility/fecundity1.35227269
54MP0008961_abnormal_basal_metabolism1.34600321
55MP0001293_anophthalmia1.33386598
56MP0008872_abnormal_physiological_respon1.32314496
57MP0008057_abnormal_DNA_replication1.31862361
58MP0008007_abnormal_cellular_replicative1.27640837
59MP0001440_abnormal_grooming_behavior1.24192073
60MP0002938_white_spotting1.23249496
61MP0001545_abnormal_hematopoietic_system1.22296709
62MP0005397_hematopoietic_system_phenotyp1.22296709
63MP0002638_abnormal_pupillary_reflex1.21073264
64MP0003121_genomic_imprinting1.20339735
65MP0001968_abnormal_touch/_nociception1.20196842
66MP0001501_abnormal_sleep_pattern1.19653612
67MP0003195_calcinosis1.18512353
68MP0003077_abnormal_cell_cycle1.17430217
69MP0004133_heterotaxia1.17333913
70MP0005253_abnormal_eye_physiology1.16362122
71MP0004233_abnormal_muscle_weight1.15940953
72MP0002254_reproductive_system_inflammat1.15825085
73MP0002822_catalepsy1.14421862
74MP0002735_abnormal_chemical_nociception1.12920925
75MP0000350_abnormal_cell_proliferation1.12260361
76MP0001919_abnormal_reproductive_system1.12082422
77MP0003075_altered_response_to1.10966154
78MP0003136_yellow_coat_color1.10784636
79MP0001849_ear_inflammation1.09974460
80MP0001730_embryonic_growth_arrest1.09096353
81MP0000653_abnormal_sex_gland1.08346969
82MP0000427_abnormal_hair_cycle1.07961730
83MP0004142_abnormal_muscle_tone1.07641753
84MP0003300_gastrointestinal_ulcer1.07500132
85MP0005187_abnormal_penis_morphology1.07469941
86MP0003890_abnormal_embryonic-extraembry1.05743887
87MP0003942_abnormal_urinary_system1.04641979
88MP0000383_abnormal_hair_follicle1.04272896
89MP0004215_abnormal_myocardial_fiber1.01434718
90MP0009250_abnormal_appendicular_skeleto1.01015583
91MP0002160_abnormal_reproductive_system1.00954637
92MP0003880_abnormal_central_pattern1.00878493
93MP0003045_fibrosis0.99303737
94MP0003755_abnormal_palate_morphology0.99131150
95MP0003436_decreased_susceptibility_to0.98165586
96MP0003938_abnormal_ear_development0.97758060
97MP0002084_abnormal_developmental_patter0.97231442
98MP0008058_abnormal_DNA_repair0.95966822
99MP0004197_abnormal_fetal_growth/weight/0.95465868
100* MP0002086_abnormal_extraembryonic_tissu0.94961033
101MP0008932_abnormal_embryonic_tissue0.93935701
102MP0004510_myositis0.93318451
103MP0003633_abnormal_nervous_system0.92772391
104MP0003861_abnormal_nervous_system0.92579721
105MP0003183_abnormal_peptide_metabolism0.91965604
106MP0000778_abnormal_nervous_system0.91011703
107MP0000604_amyloidosis0.90977305
108MP0002085_abnormal_embryonic_tissue0.90379568
109MP0002163_abnormal_gland_morphology0.89785778
110MP0002184_abnormal_innervation0.89529900
111MP0005167_abnormal_blood-brain_barrier0.88936303
112MP0003936_abnormal_reproductive_system0.88568798
113MP0003091_abnormal_cell_migration0.87629442
114MP0003879_abnormal_hair_cell0.87069408
115MP0005423_abnormal_somatic_nervous0.84997207
116MP0008569_lethality_at_weaning0.84625072
117MP0001286_abnormal_eye_development0.84587249
118MP0005621_abnormal_cell_physiology0.84331953
119MP0004147_increased_porphyrin_level0.82618508
120MP0000647_abnormal_sebaceous_gland0.82341874
121MP0009780_abnormal_chondrocyte_physiolo0.81819830
122MP0001672_abnormal_embryogenesis/_devel0.81555034
123MP0005380_embryogenesis_phenotype0.81555034
124MP0003448_altered_tumor_morphology0.80484835
125MP0006276_abnormal_autonomic_nervous0.80023198
126MP0008995_early_reproductive_senescence0.79913438
127MP0006035_abnormal_mitochondrial_morpho0.79692370
128MP0001984_abnormal_olfaction0.79423821
129MP0002736_abnormal_nociception_after0.79297956
130MP0005174_abnormal_tail_pigmentation0.79254488
131MP0008770_decreased_survivor_rate0.78537074
132MP0000372_irregular_coat_pigmentation0.78255322
133MP0000371_diluted_coat_color0.78142604
134MP0005379_endocrine/exocrine_gland_phen0.78125904
135MP0004858_abnormal_nervous_system0.78099261
136MP0005166_decreased_susceptibility_to0.77804569
137MP0000955_abnormal_spinal_cord0.77702554
138MP0001486_abnormal_startle_reflex0.77618856
139MP0002752_abnormal_somatic_nervous0.77393570
140MP0002557_abnormal_social/conspecific_i0.76240101
141MP0002398_abnormal_bone_marrow0.75307478
142MP0003984_embryonic_growth_retardation0.74987148
143MP0009703_decreased_birth_body0.74810116
144MP0005384_cellular_phenotype0.74159707
145MP0000428_abnormal_craniofacial_morphol0.73426612
146MP0002067_abnormal_sensory_capabilities0.73378376
147MP0002088_abnormal_embryonic_growth/wei0.73233672
148MP0002272_abnormal_nervous_system0.72158772
149MP0002152_abnormal_brain_morphology0.71574845
150MP0001697_abnormal_embryo_size0.70830793
151* MP0002080_prenatal_lethality0.70779045
152MP0005386_behavior/neurological_phenoty0.70402103
153MP0004924_abnormal_behavior0.70402103
154MP0003566_abnormal_cell_adhesion0.70195040
155MP0004947_skin_inflammation0.68036214
156MP0003631_nervous_system_phenotype0.67922357
157MP0002733_abnormal_thermal_nociception0.67216106
158MP0000703_abnormal_thymus_morphology0.65898039
159MP0003693_abnormal_embryo_hatching0.65844603
160MP0002734_abnormal_mechanical_nocicepti0.65772267
161MP0001177_atelectasis0.65509579
162MP0004957_abnormal_blastocyst_morpholog0.65087255

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.21266221
2Absent/shortened dynein arms (HP:0200106)5.21266221
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.20456394
4Abnormality of the lower motor neuron (HP:0002366)4.74292559
5True hermaphroditism (HP:0010459)3.39352180
6Rhinitis (HP:0012384)3.38792720
7Pancreatic cysts (HP:0001737)3.36385989
8Abnormal respiratory motile cilium physiology (HP:0012261)3.35635015
9Abnormal respiratory motile cilium morphology (HP:0005938)3.20757792
10Abnormal respiratory epithelium morphology (HP:0012253)3.20757792
11Pendular nystagmus (HP:0012043)3.19654948
12Amyotrophic lateral sclerosis (HP:0007354)3.18049553
13Absent frontal sinuses (HP:0002688)3.17790683
14Pancreatic fibrosis (HP:0100732)3.16329581
15Upper motor neuron abnormality (HP:0002127)2.95385291
16Focal seizures (HP:0007359)2.86928053
17Chronic bronchitis (HP:0004469)2.78045233
18Abnormal lung lobation (HP:0002101)2.76481102
19Nasal polyposis (HP:0100582)2.74792819
20Infertility (HP:0000789)2.71819678
21Focal motor seizures (HP:0011153)2.71484426
22Methylmalonic acidemia (HP:0002912)2.68809193
23Abnormality of ocular smooth pursuit (HP:0000617)2.63487726
24Gonadotropin excess (HP:0000837)2.62372969
25Abnormality of chromosome stability (HP:0003220)2.58752100
26Inappropriate behavior (HP:0000719)2.53301594
27Visual hallucinations (HP:0002367)2.51470948
28Abnormality of the astrocytes (HP:0100707)2.50667141
29Astrocytoma (HP:0009592)2.50667141
30Septo-optic dysplasia (HP:0100842)2.47620046
31Agnosia (HP:0010524)2.46897723
32Gaze-evoked nystagmus (HP:0000640)2.45251946
33Ependymoma (HP:0002888)2.43274168
34Abnormal ciliary motility (HP:0012262)2.39172888
35Mutism (HP:0002300)2.38791400
36Epileptic encephalopathy (HP:0200134)2.38457787
37Meckel diverticulum (HP:0002245)2.38214787
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.36369016
39Abolished electroretinogram (ERG) (HP:0000550)2.35060519
40Abnormality of the ileum (HP:0001549)2.32313970
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31968133
42Papilledema (HP:0001085)2.31498775
43Impaired vibration sensation in the lower limbs (HP:0002166)2.31251646
44Chromsome breakage (HP:0040012)2.31177508
45Shoulder girdle muscle weakness (HP:0003547)2.30908540
46Abnormality of midbrain morphology (HP:0002418)2.30040821
47Molar tooth sign on MRI (HP:0002419)2.30040821
48Small hand (HP:0200055)2.29897547
49Urinary bladder sphincter dysfunction (HP:0002839)2.29003153
50Pelvic girdle muscle weakness (HP:0003749)2.28646878
51Impaired smooth pursuit (HP:0007772)2.28407784
52Disinhibition (HP:0000734)2.27910182
53Heterotopia (HP:0002282)2.25599356
54Furrowed tongue (HP:0000221)2.23720733
55Abnormality of the labia minora (HP:0012880)2.23563778
56Hypoplastic pelvis (HP:0008839)2.22981568
57Decreased central vision (HP:0007663)2.22877001
58Congenital stationary night blindness (HP:0007642)2.20861681
59Progressive cerebellar ataxia (HP:0002073)2.18774041
60Postural instability (HP:0002172)2.18654689
61Asplenia (HP:0001746)2.16255392
62Abnormality of the nasal mucosa (HP:0000433)2.13710797
63Stenosis of the external auditory canal (HP:0000402)2.12627930
64Resting tremor (HP:0002322)2.12553033
65Dysmetric saccades (HP:0000641)2.10275671
66Abnormality of DNA repair (HP:0003254)2.09161722
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.09075999
68Pointed chin (HP:0000307)2.07970254
69Abnormality of the anterior horn cell (HP:0006802)2.07867556
70Degeneration of anterior horn cells (HP:0002398)2.07867556
71Conjunctival hamartoma (HP:0100780)2.06774352
72Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.06591968
73Myokymia (HP:0002411)2.04620893
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.04114043
75Spinal muscular atrophy (HP:0007269)2.02022548
76Urinary urgency (HP:0000012)2.02000648
77Nephroblastoma (Wilms tumor) (HP:0002667)2.01765393
78Hand muscle atrophy (HP:0009130)2.01478495
79Bronchitis (HP:0012387)1.99850314
80Truncal ataxia (HP:0002078)1.99596561
81Abnormality of homocysteine metabolism (HP:0010919)1.99569180
82Homocystinuria (HP:0002156)1.99569180
83Male pseudohermaphroditism (HP:0000037)1.99241033
84Prominent nose (HP:0000448)1.96922892
85Chorioretinal atrophy (HP:0000533)1.95373201
86Deep palmar crease (HP:0006191)1.95110149
87Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94992270
88Distal upper limb amyotrophy (HP:0007149)1.93357163
89Upper limb amyotrophy (HP:0009129)1.93357163
90Volvulus (HP:0002580)1.92228153
91Embryonal renal neoplasm (HP:0011794)1.92047565
92Morphological abnormality of the middle ear (HP:0008609)1.91529208
93Ectopic kidney (HP:0000086)1.91016324
94Abnormality of the preputium (HP:0100587)1.90991402
95Apathy (HP:0000741)1.90505727
96Cystic liver disease (HP:0006706)1.89761689
97Sloping forehead (HP:0000340)1.89646832
98Febrile seizures (HP:0002373)1.89561052
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89352821
100Neuronal loss in central nervous system (HP:0002529)1.88991296
101Bronchiectasis (HP:0002110)1.88197516
102Abnormality of the hip-girdle musculature (HP:0001445)1.87799844
103Abnormality of the musculature of the pelvis (HP:0001469)1.87799844
104Absence seizures (HP:0002121)1.87318080
105Abnormality of the phalanges of the 5th finger (HP:0004213)1.86867487
106Meningioma (HP:0002858)1.86631648
107Hyperventilation (HP:0002883)1.86271723
108Atrophy/Degeneration involving motor neurons (HP:0007373)1.85495745
109Abnormality of the proximal phalanges of the hand (HP:0009834)1.84587247
110Abnormality of the renal collecting system (HP:0004742)1.84574154
111Lower limb amyotrophy (HP:0007210)1.84413741
112Ankyloglossia (HP:0010296)1.84345738
113Urethral obstruction (HP:0000796)1.84345714
114Chronic hepatic failure (HP:0100626)1.83925472
115Poor eye contact (HP:0000817)1.83363663
116Absent thumb (HP:0009777)1.83236742
117Abnormality of the renal medulla (HP:0100957)1.83045328
118Short tibia (HP:0005736)1.82712966
119Optic nerve hypoplasia (HP:0000609)1.82448458
120Genital tract atresia (HP:0001827)1.80741062
121Male infertility (HP:0003251)1.80585975
122Increased cerebral lipofuscin (HP:0011813)1.80470174
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.80080191
124Abnormality of alanine metabolism (HP:0010916)1.79987742
125Hyperalaninemia (HP:0003348)1.79987742
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79987742
127Sclerocornea (HP:0000647)1.79862984
128Intellectual disability, profound (HP:0002187)1.79699332
129Aplasia/Hypoplasia of the tongue (HP:0010295)1.79374134
130Glioma (HP:0009733)1.78922306
131Aplasia/Hypoplasia of the patella (HP:0006498)1.78318656
132Difficulty climbing stairs (HP:0003551)1.77828055
133Small intestinal stenosis (HP:0012848)1.77488490
134Duodenal stenosis (HP:0100867)1.77488490
135Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77335687
136Colon cancer (HP:0003003)1.77329920
137Subacute progressive viral hepatitis (HP:0006572)1.76740008
138Vaginal atresia (HP:0000148)1.76581002
139Impaired social interactions (HP:0000735)1.75290538
140Abnormal social behavior (HP:0012433)1.75290538
141Increased corneal curvature (HP:0100692)1.74811430
142Keratoconus (HP:0000563)1.74811430
143Frequent falls (HP:0002359)1.74588513
144Hamartoma of the eye (HP:0010568)1.73436791
145Impaired vibratory sensation (HP:0002495)1.73088177
146Anomalous pulmonary venous return (HP:0010772)1.72989705
147Global brain atrophy (HP:0002283)1.72862847
148Methylmalonic aciduria (HP:0012120)1.72470845
149Annular pancreas (HP:0001734)1.71599315
150Nephronophthisis (HP:0000090)1.69670089
151Hypoplasia of the uterus (HP:0000013)1.69085292
152Fibular aplasia (HP:0002990)1.68855332
153Birth length less than 3rd percentile (HP:0003561)1.68748127
154Abnormality of the renal cortex (HP:0011035)1.68662565
155Diminished motivation (HP:0000745)1.68527743
156Abnormality of the frontal sinuses (HP:0002687)1.67376383
157Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66867180
158Degeneration of the lateral corticospinal tracts (HP:0002314)1.66867180
159Personality changes (HP:0000751)1.66443267
160Abnormality of methionine metabolism (HP:0010901)1.66255161
161Hyperacusis (HP:0010780)1.65431818
162Attenuation of retinal blood vessels (HP:0007843)1.65330838
163Achilles tendon contracture (HP:0001771)1.65259696
164Absent speech (HP:0001344)1.65185295
165Patellar aplasia (HP:0006443)1.64987332
166Spastic tetraparesis (HP:0001285)1.64712610
167Confusion (HP:0001289)1.64482563
168High pitched voice (HP:0001620)1.64092525
169Impulsivity (HP:0100710)1.62976022
170Generalized tonic-clonic seizures (HP:0002069)1.62949735
171Abnormal rod and cone electroretinograms (HP:0008323)1.62719994
172Hyperglycinemia (HP:0002154)1.62668000
173Anencephaly (HP:0002323)1.61696419
174Abnormality of serum amino acid levels (HP:0003112)1.61169183
175Abnormality of the motor neurons (HP:0002450)1.61126756
176Abnormal neuron morphology (HP:0012757)1.61126756
177Depression (HP:0000716)1.60946593
178Dialeptic seizures (HP:0011146)1.60875823
179Abnormality of the carotid arteries (HP:0005344)1.59992640
180Bilateral microphthalmos (HP:0007633)1.59962748
181Genetic anticipation (HP:0003743)1.59876882
182Carpal bone hypoplasia (HP:0001498)1.59771451
183Short hallux (HP:0010109)1.59667053
184Ankle clonus (HP:0011448)1.57999121
185Neoplasm of the adrenal cortex (HP:0100641)1.57811207
186Abnormality of the nasal septum (HP:0000419)1.57630248
187Medial flaring of the eyebrow (HP:0010747)1.57453182
188Truncal obesity (HP:0001956)1.57388114
189Atonic seizures (HP:0010819)1.57248955
190Postaxial foot polydactyly (HP:0001830)1.57134349
191Abnormality of the duodenum (HP:0002246)1.56523429
192Supranuclear gaze palsy (HP:0000605)1.56400671
193Abnormality of aspartate family amino acid metabolism (HP:0010899)1.55768428
194Protruding tongue (HP:0010808)1.55652755
195Bladder carcinoma (HP:0002862)1.55521399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.52319026
2PDK34.52319026
3PDK23.81123455
4RIPK43.21277996
5MAP3K93.07434093
6FRK3.04816087
7ZAK2.88487620
8PRKD32.68707696
9CASK2.39705526
10CDK122.30275571
11BUB12.18959649
12TAF12.18593445
13MST42.18500400
14NEK12.18441518
15TNIK2.16294097
16NTRK32.11047417
17GRK12.08764171
18EPHA42.03910081
19PNCK2.03625603
20ACVR1B1.98770502
21TESK11.96823180
22KSR21.94740139
23STK381.92903135
24NEK21.91335265
25TYRO31.88851743
26NUAK11.85407781
27BMPR1B1.84856796
28BRSK21.84214830
29MKNK21.83673540
30SCYL21.81814359
31CAMKK11.81206822
32TRIM281.79062492
33CDC71.78742418
34EIF2AK31.77626064
35PAK61.77044336
36KSR11.73905233
37MINK11.72845759
38STK161.67765900
39PLK41.67386689
40ALK1.60726285
41PINK11.58302393
42ADRBK21.57326812
43MAP3K41.51233841
44STK38L1.45288463
45ICK1.42580059
46MKNK11.39989907
47DAPK21.38541427
48SIK21.36756914
49PDK11.36667994
50WNK31.35769258
51PLK11.35537767
52PTK2B1.31754503
53BCR1.31057137
54TAOK11.30673640
55SRPK11.27981786
56PBK1.27517093
57LATS11.20456836
58MAP3K101.20056558
59RIPK11.14754051
60OXSR11.14660294
61PLK21.11054405
62VRK11.10291713
63BRD41.07879618
64PHKG21.02534543
65PHKG11.02534543
66VRK21.01996606
67TLK11.00702139
68EEF2K0.98343786
69CSNK1G20.96895193
70CDK190.96500609
71MAP3K20.93557712
72PKN20.92593801
73DAPK10.91757494
74MAP4K20.90918100
75CSNK1G10.88575746
76INSRR0.87518434
77PDPK10.85767029
78TRIB30.84460924
79NTRK20.82406300
80DYRK20.80718440
81SGK30.80524720
82CLK10.78971038
83CCNB10.78418575
84CAMK1G0.77107033
85WNK40.75903298
86RET0.75022008
87DYRK30.74789239
88EIF2AK20.71428778
89STK390.71254092
90ERBB30.71138181
91CDK60.70140191
92FES0.69319342
93AKT30.68946687
94MAP3K50.68461262
95CAMKK20.67354214
96NME10.66896432
97PAK30.66660811
98TTK0.66621368
99MAP3K130.65918521
100* CHEK10.65360754
101RAF10.63967900
102CSNK1E0.62677774
103LATS20.62442334
104GRK50.61969508
105CDK50.61882801
106MAPKAPK50.61761680
107MAP2K40.61590228
108AURKA0.61285257
109MAPK130.59021470
110PRKCE0.58204871
111CDK30.57876193
112MAPK100.57763816
113CSNK1G30.57441388
114AURKB0.57324489
115MTOR0.56654874
116MARK10.55987416
117STK30.55537087
118MAP4K10.54363527
119OBSCN0.53805499
120STK100.52540040
121RPS6KB10.52217347
122PDGFRA0.51813384
123CSNK1A1L0.50928612
124HCK0.50872940
125STK110.50711007
126ATR0.49668552
127PRKCI0.49581885
128CDK10.48893696
129BRSK10.48787850
130PDGFRB0.48142249
131TSSK60.47612990
132TAOK30.47087042
133CDK180.46801933
134CSNK1A10.45959082
135SGK10.45602056
136PLK30.45316121
137PRKCG0.45207617
138CSNK1D0.44644771
139MAPK80.44622241
140MAP2K70.44380637
141ATM0.44224544
142STK240.43556252
143WNK10.43250994
144FGFR10.43194027
145CDK150.43139951
146CDK20.42495291
147PRKCH0.42449087
148BRAF0.42011805
149PRKDC0.40833032
150EIF2AK10.40750359
151SGK20.40683090
152PAK40.40127426
153CDK40.39467908
154DYRK1A0.38993038
155TAOK20.38846040
156WEE10.38725485
157SIK30.35934536
158NTRK10.35757376
159CDK140.35316631
160CDK11A0.33602511
161SYK0.33571682
162RPS6KA40.32614020
163RPS6KA30.32533864
164EGFR0.32303060
165CHEK20.31953202
166CDC42BPA0.30724243
167MAP3K80.30034269
168PAK20.30019948
169PIM10.29861966

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.91897679
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71432691
3Protein export_Homo sapiens_hsa030602.70547843
4Basal transcription factors_Homo sapiens_hsa030222.43759151
5Mismatch repair_Homo sapiens_hsa034302.39904646
6DNA replication_Homo sapiens_hsa030302.35870623
7RNA degradation_Homo sapiens_hsa030182.17998857
8Long-term potentiation_Homo sapiens_hsa047202.16969024
9Nucleotide excision repair_Homo sapiens_hsa034202.14422958
10Synaptic vesicle cycle_Homo sapiens_hsa047212.10622509
11Selenocompound metabolism_Homo sapiens_hsa004502.03875237
12Non-homologous end-joining_Homo sapiens_hsa034502.03484818
13Fanconi anemia pathway_Homo sapiens_hsa034602.00083923
14RNA polymerase_Homo sapiens_hsa030201.94755368
15One carbon pool by folate_Homo sapiens_hsa006701.88965886
16Dorso-ventral axis formation_Homo sapiens_hsa043201.73608629
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73216951
18Phototransduction_Homo sapiens_hsa047441.71206746
19Amphetamine addiction_Homo sapiens_hsa050311.66444351
20Olfactory transduction_Homo sapiens_hsa047401.64907819
21Oocyte meiosis_Homo sapiens_hsa041141.59294906
22Spliceosome_Homo sapiens_hsa030401.59052301
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52556568
24Cell cycle_Homo sapiens_hsa041101.48605349
25Propanoate metabolism_Homo sapiens_hsa006401.44340023
26Nicotine addiction_Homo sapiens_hsa050331.43794848
27Oxidative phosphorylation_Homo sapiens_hsa001901.42172008
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41380451
29B cell receptor signaling pathway_Homo sapiens_hsa046621.39662777
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38465405
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37506485
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37050142
33mTOR signaling pathway_Homo sapiens_hsa041501.34002069
34VEGF signaling pathway_Homo sapiens_hsa043701.33684172
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32925115
36Glioma_Homo sapiens_hsa052141.32432196
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31279266
38Estrogen signaling pathway_Homo sapiens_hsa049151.31004397
39Circadian entrainment_Homo sapiens_hsa047131.29428651
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.28092517
41Parkinsons disease_Homo sapiens_hsa050121.27278443
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24127306
43Dopaminergic synapse_Homo sapiens_hsa047281.22600142
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21214940
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20110089
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19809574
47Proteasome_Homo sapiens_hsa030501.17756897
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17680938
49Salivary secretion_Homo sapiens_hsa049701.17565949
50Glutamatergic synapse_Homo sapiens_hsa047241.17181703
51Osteoclast differentiation_Homo sapiens_hsa043801.16842720
52Renin secretion_Homo sapiens_hsa049241.11468834
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10310573
54Oxytocin signaling pathway_Homo sapiens_hsa049211.09205022
55Melanoma_Homo sapiens_hsa052181.08844085
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.08586372
57Huntingtons disease_Homo sapiens_hsa050161.08531743
58Non-small cell lung cancer_Homo sapiens_hsa052231.08527800
59Morphine addiction_Homo sapiens_hsa050321.06825477
60Type II diabetes mellitus_Homo sapiens_hsa049301.05630024
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04888544
62Cardiac muscle contraction_Homo sapiens_hsa042601.03930787
63Ribosome_Homo sapiens_hsa030101.03491636
64mRNA surveillance pathway_Homo sapiens_hsa030151.03152150
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.03036610
66Caffeine metabolism_Homo sapiens_hsa002321.02692146
67GnRH signaling pathway_Homo sapiens_hsa049121.02420504
68Hedgehog signaling pathway_Homo sapiens_hsa043401.00671489
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99712383
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98494206
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98033961
72Gastric acid secretion_Homo sapiens_hsa049710.97978475
73ErbB signaling pathway_Homo sapiens_hsa040120.97850233
74Base excision repair_Homo sapiens_hsa034100.97827830
75T cell receptor signaling pathway_Homo sapiens_hsa046600.97770418
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96987451
77Butanoate metabolism_Homo sapiens_hsa006500.96939867
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96599354
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96187194
80Chronic myeloid leukemia_Homo sapiens_hsa052200.94711942
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94333497
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93832216
83Colorectal cancer_Homo sapiens_hsa052100.93444710
84Glucagon signaling pathway_Homo sapiens_hsa049220.92714738
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92471678
86Collecting duct acid secretion_Homo sapiens_hsa049660.92292797
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91391204
88Endometrial cancer_Homo sapiens_hsa052130.91387549
89Tuberculosis_Homo sapiens_hsa051520.90908864
90Tryptophan metabolism_Homo sapiens_hsa003800.89808173
91Long-term depression_Homo sapiens_hsa047300.89625433
92Cholinergic synapse_Homo sapiens_hsa047250.89380293
93MAPK signaling pathway_Homo sapiens_hsa040100.89054218
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88832044
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.88422656
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.88283220
97Purine metabolism_Homo sapiens_hsa002300.86979310
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86066471
99Insulin secretion_Homo sapiens_hsa049110.85538242
100GABAergic synapse_Homo sapiens_hsa047270.85250409
101Nitrogen metabolism_Homo sapiens_hsa009100.85029742
102Alzheimers disease_Homo sapiens_hsa050100.84874999
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84412904
104Inositol phosphate metabolism_Homo sapiens_hsa005620.83688797
105Circadian rhythm_Homo sapiens_hsa047100.83166836
106Endocytosis_Homo sapiens_hsa041440.80691387
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80295814
108Pyrimidine metabolism_Homo sapiens_hsa002400.80217033
109Retinol metabolism_Homo sapiens_hsa008300.80088203
110Choline metabolism in cancer_Homo sapiens_hsa052310.79769212
111Calcium signaling pathway_Homo sapiens_hsa040200.79479597
112cAMP signaling pathway_Homo sapiens_hsa040240.77022864
113p53 signaling pathway_Homo sapiens_hsa041150.76778654
114Salmonella infection_Homo sapiens_hsa051320.76539784
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75929374
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.75249465
117HIF-1 signaling pathway_Homo sapiens_hsa040660.74214584
118Cocaine addiction_Homo sapiens_hsa050300.74139698
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73923465
120Basal cell carcinoma_Homo sapiens_hsa052170.73818095
121Hippo signaling pathway_Homo sapiens_hsa043900.73279608
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72808397
123Acute myeloid leukemia_Homo sapiens_hsa052210.72623768
124Shigellosis_Homo sapiens_hsa051310.72111095
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72100188
126* RNA transport_Homo sapiens_hsa030130.71009664
127Chemical carcinogenesis_Homo sapiens_hsa052040.70923721
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70673976
129Serotonergic synapse_Homo sapiens_hsa047260.69128472
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68638327
131Steroid biosynthesis_Homo sapiens_hsa001000.68342959
132Chemokine signaling pathway_Homo sapiens_hsa040620.68083892
133Toxoplasmosis_Homo sapiens_hsa051450.67211672
134Hepatitis B_Homo sapiens_hsa051610.66934475
135Vitamin digestion and absorption_Homo sapiens_hsa049770.66505128
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66296684
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65861889
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65144372
139Leishmaniasis_Homo sapiens_hsa051400.64587352
140TGF-beta signaling pathway_Homo sapiens_hsa043500.64517383
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.64430067
142Gap junction_Homo sapiens_hsa045400.64256233
143Pyruvate metabolism_Homo sapiens_hsa006200.64222623
144Renal cell carcinoma_Homo sapiens_hsa052110.64068276
145Antigen processing and presentation_Homo sapiens_hsa046120.63597397
146Sulfur metabolism_Homo sapiens_hsa009200.63200981
147Influenza A_Homo sapiens_hsa051640.62216962
148Pancreatic cancer_Homo sapiens_hsa052120.61819521
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.60739052
150Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60679586
151Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60404486
152Prolactin signaling pathway_Homo sapiens_hsa049170.60398820
153TNF signaling pathway_Homo sapiens_hsa046680.59694906
154Linoleic acid metabolism_Homo sapiens_hsa005910.59660545
155Viral carcinogenesis_Homo sapiens_hsa052030.59609281
156beta-Alanine metabolism_Homo sapiens_hsa004100.59138480
157Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59022303
158Adherens junction_Homo sapiens_hsa045200.58986413
159* Wnt signaling pathway_Homo sapiens_hsa043100.58540920
160AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58048420
161Regulation of autophagy_Homo sapiens_hsa041400.57919411
162Taste transduction_Homo sapiens_hsa047420.57896264
163Legionellosis_Homo sapiens_hsa051340.55831138
164NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55339875
165HTLV-I infection_Homo sapiens_hsa051660.55265054
166Insulin signaling pathway_Homo sapiens_hsa049100.54983426
167Rap1 signaling pathway_Homo sapiens_hsa040150.54864735
168FoxO signaling pathway_Homo sapiens_hsa040680.54808399
169Folate biosynthesis_Homo sapiens_hsa007900.53800801
170Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50169447
171Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50016109
172Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49634008
173Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48093050
174Fatty acid biosynthesis_Homo sapiens_hsa000610.46703484
175Alcoholism_Homo sapiens_hsa050340.43275561
176Ether lipid metabolism_Homo sapiens_hsa005650.42610229
177Metabolic pathways_Homo sapiens_hsa011000.42316481
178Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42183587
179Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41970699
180N-Glycan biosynthesis_Homo sapiens_hsa005100.40857084

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