ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	4.21277453
2	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.10008445
3	mitotic cell cycle arrest (GO:0071850)	4.05221964
4	sleep (GO:0030431)	3.88652734
5	rRNA modification (GO:0000154)	3.85604778
6	rRNA methylation (GO:0031167)	3.84468837
7	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.73690428
8	DNA deamination (GO:0045006)	3.63151727
9	UV protection (GO:0009650)	3.48718796
10	response to gravity (GO:0009629)	3.48690111
11	positive regulation of defense response to virus by host (GO:0002230)	3.48284378
12	regulation of defense response to virus by host (GO:0050691)	3.45739627
13	response to muramyl dipeptide (GO:0032495)	3.44702083
14	positive regulation of prostaglandin secretion (GO:0032308)	3.44420307
15	DNA strand renaturation (GO:0000733)	3.41255663
16	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	3.40304360
17	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.39857456
18	cellular response to ATP (GO:0071318)	3.37371688
19	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	3.35067771
20	negative regulation of cell killing (GO:0031342)	3.35067771
21	cellular response to exogenous dsRNA (GO:0071360)	3.30733369
22	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.29240954
23	GDP-mannose metabolic process (GO:0019673)	3.25090994
24	positive regulation of heat generation (GO:0031652)	3.21369047
25	mast cell activation involved in immune response (GO:0002279)	3.16736288
26	mast cell degranulation (GO:0043303)	3.16736288
27	cellular response to interleukin-15 (GO:0071350)	3.09470420
28	RNA destabilization (GO:0050779)	3.08726794
29	rRNA catabolic process (GO:0016075)	3.08706875
30	base-excision repair, AP site formation (GO:0006285)	3.07150695
31	mast cell activation (GO:0045576)	3.06743646
32	attachment of spindle microtubules to kinetochore (GO:0008608)	3.04799731
33	folic acid metabolic process (GO:0046655)	3.01786005
34	meiotic chromosome segregation (GO:0045132)	2.97895327
35	tRNA modification (GO:0006400)	2.96180217
36	regulation of prostaglandin secretion (GO:0032306)	2.95234540
37	regulation of germinal center formation (GO:0002634)	2.93278393
38	interferon-gamma production (GO:0032609)	2.92434644
39	pseudouridine synthesis (GO:0001522)	2.92072165
40	positive thymic T cell selection (GO:0045059)	2.90998445
41	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.88010933
42	tolerance induction (GO:0002507)	2.85800805
43	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.83659059
44	production of molecular mediator involved in inflammatory response (GO:0002532)	2.83015686
45	piRNA metabolic process (GO:0034587)	2.80553196
46	negative regulation of cell aging (GO:0090344)	2.74064168
47	tumor necrosis factor-mediated signaling pathway (GO:0033209)	2.73471731
48	cellular response to dsRNA (GO:0071359)	2.69766602
49	DNA replication checkpoint (GO:0000076)	2.69725206
50	ribosome assembly (GO:0042255)	2.68763201
51	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.67991202
52	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.66658074
53	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.65849993
54	termination of RNA polymerase III transcription (GO:0006386)	2.65849993
55	purine deoxyribonucleotide catabolic process (GO:0009155)	2.64114344
56	methionine biosynthetic process (GO:0009086)	2.63171235
57	adenosine metabolic process (GO:0046085)	2.63034942
58	iron-sulfur cluster assembly (GO:0016226)	2.62852087
59	metallo-sulfur cluster assembly (GO:0031163)	2.62852087
60	leukocyte degranulation (GO:0043299)	2.62541087
61	negative thymic T cell selection (GO:0045060)	2.62532589
62	negative regulation of innate immune response (GO:0045824)	2.60346273
63	regulation of skeletal muscle contraction (GO:0014819)	2.59016926
64	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.56807008
65	positive regulation of T-helper 1 type immune response (GO:0002827)	2.56013341
66	regulation of T cell mediated cytotoxicity (GO:0001914)	2.55771399
67	preassembly of GPI anchor in ER membrane (GO:0016254)	2.53761419
68	mitochondrial RNA metabolic process (GO:0000959)	2.53671884
69	RNA methylation (GO:0001510)	2.51967464
70	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.50805062
71	nucleotide transmembrane transport (GO:1901679)	2.47838183
72	positive regulation of T cell cytokine production (GO:0002726)	2.47342262
73	nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)	2.46372053
74	negative T cell selection (GO:0043383)	2.44879298
75	folic acid-containing compound biosynthetic process (GO:0009396)	2.41648510
76	DNA catabolic process, exonucleolytic (GO:0000738)	2.40911710
77	positive regulation of T cell mediated immunity (GO:0002711)	2.40367743
78	regulation of memory T cell differentiation (GO:0043380)	2.40128363
79	cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)	2.39554142
80	response to interleukin-15 (GO:0070672)	2.38933808
81	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.38789143
82	regulation of B cell receptor signaling pathway (GO:0050855)	2.37833927
83	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	2.37294728
84	L-methionine biosynthetic process (GO:0071265)	2.36212550
85	amino acid salvage (GO:0043102)	2.36212550
86	L-methionine salvage (GO:0071267)	2.36212550
87	tRNA methylation (GO:0030488)	2.35907321
88	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.35852308
89	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.35852308
90	isotype switching (GO:0045190)	2.35852308
91	regulation of immunoglobulin secretion (GO:0051023)	2.34778283
92	RNA modification (GO:0009451)	2.34476751
93	positive regulation of osteoclast differentiation (GO:0045672)	2.34130615
94	B cell homeostasis (GO:0001782)	2.33076973
95	termination of RNA polymerase I transcription (GO:0006363)	2.32333525
96	peptidyl-arginine omega-N-methylation (GO:0035247)	2.31679948
97	nuclear envelope reassembly (GO:0031468)	2.31175290
98	mitotic nuclear envelope reassembly (GO:0007084)	2.31175290
99	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.30452349
100	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.28187004

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.95474245
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.66199263
3	VDR_21846776_ChIP-Seq_THP-1_Human	2.49143751
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.47637281
5	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.47599628
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.40331058
7	XRN2_22483619_ChIP-Seq_HELA_Human	2.39972621
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.30598566
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22865324
10	E2F7_22180533_ChIP-Seq_HELA_Human	2.22083077
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.19396296
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.18116663
13	MYC_22102868_ChIP-Seq_BL_Human	2.17551371
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.13425555
15	CIITA_25753668_ChIP-Seq_RAJI_Human	2.11101187
16	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.03865649
17	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.02300731
18	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.97693218
19	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.97513385
20	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.94218798
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.93197611
22	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.91960367
23	MAF_26560356_Chip-Seq_TH1_Human	1.88156345
24	MAF_26560356_Chip-Seq_TH2_Human	1.85302608
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.85210027
26	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.80500682
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77218560
28	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76800196
29	DCP1A_22483619_ChIP-Seq_HELA_Human	1.72509586
30	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.72100667
31	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.69998476
32	GABP_19822575_ChIP-Seq_HepG2_Human	1.68020220
33	UTX_26944678_Chip-Seq_JUKART_Human	1.67647513
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.65437154
35	P68_20966046_ChIP-Seq_HELA_Human	1.64207333
36	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.63329426
37	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.60888354
38	BCL6_27268052_Chip-Seq_Bcells_Human	1.59819757
39	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.58420433
40	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.56952848
41	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.56035843
42	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.52297424
43	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.51408526
44	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.50194934
45	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.49051424
46	BCOR_27268052_Chip-Seq_Bcells_Human	1.47457518
47	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.46678833
48	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.45612088
49	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.44403559
50	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.43971447
51	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43968119
52	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.43322484
53	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.42530915
54	VDR_24763502_ChIP-Seq_THP-1_Human	1.42390757
55	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.42365733
56	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.42168420
57	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.40545166
58	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.40400175
59	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.40250190
60	SPI1_23547873_ChIP-Seq_NB4_Human	1.38744422
61	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.38240656
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.37955723
63	TTF2_22483619_ChIP-Seq_HELA_Human	1.37618781
64	E2F1_20622854_ChIP-Seq_HELA_Human	1.37179090
65	MYB_26560356_Chip-Seq_TH2_Human	1.36402766
66	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.34429053
67	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.33711565
68	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.28312146
69	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.27431597
70	KDM5A_27292631_Chip-Seq_BREAST_Human	1.27312536
71	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.24979584
72	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.24633784
73	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.23666357
74	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.22563883
75	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.21169288
76	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.20534722
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19726714
78	MYB_26560356_Chip-Seq_TH1_Human	1.19652495
79	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18955204
80	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.18870197
81	PHF8_20622854_ChIP-Seq_HELA_Human	1.18840915
82	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.18195313
83	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.17513090
84	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.17366995
85	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.17141929
86	LXR_22292898_ChIP-Seq_THP-1_Human	1.16473706
87	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13791230
88	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.13564367
89	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.13291881
90	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.12810638
91	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.12052796
92	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.10912625
93	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.09161147
94	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.09011869
95	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.08196658
96	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.07930721
97	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.07053852
98	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06977544
99	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.05820522
100	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.05407391

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003436_decreased_susceptibility_to	3.34379592
2	MP0001986_abnormal_taste_sensitivity	2.93442500
3	MP0000685_abnormal_immune_system	2.90378597
4	MP0003806_abnormal_nucleotide_metabolis	2.81020121
5	MP0001835_abnormal_antigen_presentation	2.75746743
6	MP0005174_abnormal_tail_pigmentation	2.65605467
7	MP0003763_abnormal_thymus_physiology	2.62707132
8	MP0005671_abnormal_response_to	2.59942611
9	MP0002148_abnormal_hypersensitivity_rea	2.33915574
10	MP0005000_abnormal_immune_tolerance	2.32214037
11	MP0010094_abnormal_chromosome_stability	2.30828756
12	MP0002009_preneoplasia	2.25571072
13	MP0008875_abnormal_xenobiotic_pharmacok	2.17783065
14	MP0003111_abnormal_nucleus_morphology	2.15354063
15	MP0002723_abnormal_immune_serum	2.15264379
16	MP0005171_absent_coat_pigmentation	2.11032759
17	MP0003724_increased_susceptibility_to	2.10382739
18	MP0001800_abnormal_humoral_immune	2.01713375
19	MP0002166_altered_tumor_susceptibility	1.97735512
20	MP0004947_skin_inflammation	1.96625444
21	MP0003786_premature_aging	1.95420517
22	MP0002452_abnormal_antigen_presenting	1.94820956
23	MP0001819_abnormal_immune_cell	1.83340945
24	MP0002006_tumorigenesis	1.81986472
25	MP0002420_abnormal_adaptive_immunity	1.81346127
26	MP0002398_abnormal_bone_marrow	1.81278202
27	MP0008058_abnormal_DNA_repair	1.80787557
28	MP0003828_pulmonary_edema	1.78528428
29	MP0003693_abnormal_embryo_hatching	1.77564542
30	MP0002405_respiratory_system_inflammati	1.70725252
31	MP0005083_abnormal_biliary_tract	1.69922221
32	MP0001661_extended_life_span	1.66620354
33	MP0009333_abnormal_splenocyte_physiolog	1.64931958
34	MP0002722_abnormal_immune_system	1.60678559
35	MP0000703_abnormal_thymus_morphology	1.59726282
36	MP0002019_abnormal_tumor_incidence	1.57942535
37	MP0009785_altered_susceptibility_to	1.57006500
38	MP0000716_abnormal_immune_system	1.55000063
39	MP0000689_abnormal_spleen_morphology	1.54456120
40	MP0001873_stomach_inflammation	1.53979544
41	MP0002419_abnormal_innate_immunity	1.53033654
42	MP0005058_abnormal_lysosome_morphology	1.49815909
43	MP0002429_abnormal_blood_cell	1.49805966
44	MP0003077_abnormal_cell_cycle	1.49392670
45	MP0001853_heart_inflammation	1.45411815
46	MP0005025_abnormal_response_to	1.44482644
47	MP0002933_joint_inflammation	1.43944996
48	MP0004957_abnormal_blastocyst_morpholog	1.41987870
49	MP0001533_abnormal_skeleton_physiology	1.41753430
50	MP0009764_decreased_sensitivity_to	1.35023603
51	MP0001790_abnormal_immune_system	1.34649101
52	MP0005387_immune_system_phenotype	1.34649101
53	MP0001919_abnormal_reproductive_system	1.32313780
54	MP0009840_abnormal_foam_cell	1.32287065
55	MP0003191_abnormal_cellular_cholesterol	1.30132050
56	MP0000858_altered_metastatic_potential	1.29503283
57	MP0002877_abnormal_melanocyte_morpholog	1.26395750
58	MP0003950_abnormal_plasma_membrane	1.24175831
59	MP0000015_abnormal_ear_pigmentation	1.24160934
60	MP0009278_abnormal_bone_marrow	1.21220105
61	MP0001845_abnormal_inflammatory_respons	1.21028576
62	MP0010155_abnormal_intestine_physiology	1.16129856
63	MP0008007_abnormal_cellular_replicative	1.14629063
64	MP0005464_abnormal_platelet_physiology	1.13288557
65	MP0000465_gastrointestinal_hemorrhage	1.01104172
66	MP0008469_abnormal_protein_level	1.00621814
67	MP0004147_increased_porphyrin_level	0.98901302
68	MP0001765_abnormal_ion_homeostasis	0.98634998
69	MP0000013_abnormal_adipose_tissue	0.97646634
70	MP0000358_abnormal_cell_content/	0.93569352
71	MP0005084_abnormal_gallbladder_morpholo	0.93040782
72	MP0003656_abnormal_erythrocyte_physiolo	0.91968472
73	MP0006072_abnormal_retinal_apoptosis	0.91643889
74	MP0002160_abnormal_reproductive_system	0.91628217
75	MP0005410_abnormal_fertilization	0.89221307
76	MP0005389_reproductive_system_phenotype	0.87433370
77	MP0003718_maternal_effect	0.87203044
78	MP0002876_abnormal_thyroid_physiology	0.83810839
79	MP0005332_abnormal_amino_acid	0.82569616
80	MP0009931_abnormal_skin_appearance	0.82191783
81	MP0005423_abnormal_somatic_nervous	0.79913998
82	MP0005075_abnormal_melanosome_morpholog	0.78628981
83	MP0000490_abnormal_crypts_of	0.77920367
84	MP0005076_abnormal_cell_differentiation	0.76619148
85	MP0003172_abnormal_lysosome_physiology	0.75357374
86	MP0001968_abnormal_touch/_nociception	0.73196926
87	MP0001216_abnormal_epidermal_layer	0.72777846
88	MP0001243_abnormal_dermal_layer	0.71125043
89	MP0004782_abnormal_surfactant_physiolog	0.71080774
90	MP0005501_abnormal_skin_physiology	0.69859155
91	MP0008057_abnormal_DNA_replication	0.69597752
92	MP0005330_cardiomyopathy	0.67350933
93	MP0000313_abnormal_cell_death	0.67347702
94	MP0002736_abnormal_nociception_after	0.66326992
95	MP0004043_abnormal_pH_regulation	0.65948154
96	MP0000747_muscle_weakness	0.64293017
97	MP0004808_abnormal_hematopoietic_stem	0.63299690
98	MP0008775_abnormal_heart_ventricle	0.60672021
99	MP0003448_altered_tumor_morphology	0.60472660
100	MP0002998_abnormal_bone_remodeling	0.57836399

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	4.52617636
2	Attenuation of retinal blood vessels (HP:0007843)	4.09020889
3	IgG deficiency (HP:0004315)	3.88832279
4	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.62145073
5	Facial diplegia (HP:0001349)	3.59649558
6	Poikiloderma (HP:0001029)	3.58761255
7	Squamous cell carcinoma (HP:0002860)	3.52740101
8	Dyschromatopsia (HP:0007641)	3.47303258
9	Rectovaginal fistula (HP:0000143)	3.40552144
10	Rectal fistula (HP:0100590)	3.40552144
11	Vaginal fistula (HP:0004320)	3.12887687
12	Intestinal fistula (HP:0100819)	3.12067425
13	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.97268138
14	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.91966502
15	Absent thumb (HP:0009777)	2.88973767
16	Pustule (HP:0200039)	2.81491939
17	Increased hepatocellular lipid droplets (HP:0006565)	2.73183218
18	Progressive muscle weakness (HP:0003323)	2.68951179
19	Elevated erythrocyte sedimentation rate (HP:0003565)	2.67592274
20	Abnormality of the pons (HP:0007361)	2.66964808
21	Mesangial abnormality (HP:0001966)	2.64450909
22	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.63816712
23	Joint stiffness (HP:0001387)	2.61638323
24	Hypoplasia of the pons (HP:0012110)	2.61475004
25	Increased intramyocellular lipid droplets (HP:0012240)	2.61436863
26	Lipid accumulation in hepatocytes (HP:0006561)	2.58389944
27	Congenital stationary night blindness (HP:0007642)	2.57567285
28	Renal Fanconi syndrome (HP:0001994)	2.52794552
29	Abnormal protein glycosylation (HP:0012346)	2.52614384
30	Abnormal glycosylation (HP:0012345)	2.52614384
31	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.52614384
32	Abnormal protein N-linked glycosylation (HP:0012347)	2.52614384
33	Severe combined immunodeficiency (HP:0004430)	2.50228043
34	Type I transferrin isoform profile (HP:0003642)	2.46152344
35	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.46092138
36	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.46092138
37	Abnormality of polysaccharide metabolism (HP:0011012)	2.46092138
38	Abnormality of T cell physiology (HP:0011840)	2.44277554
39	Chronic mucocutaneous candidiasis (HP:0002728)	2.43874585
40	Recurrent cutaneous fungal infections (HP:0011370)	2.43874585
41	Type 2 muscle fiber atrophy (HP:0003554)	2.41908941
42	Premature graying of hair (HP:0002216)	2.40017870
43	Muscle fiber atrophy (HP:0100295)	2.38162598
44	Increased muscle lipid content (HP:0009058)	2.35557345
45	Rib fusion (HP:0000902)	2.32602825
46	Abnormality of eosinophils (HP:0001879)	2.31878109
47	Abnormal albumin level (HP:0012116)	2.29117058
48	Hypoalbuminemia (HP:0003073)	2.29117058
49	Abnormality of T cells (HP:0002843)	2.28700582
50	Mucopolysacchariduria (HP:0008155)	2.28676566
51	Urinary glycosaminoglycan excretion (HP:0003541)	2.28676566
52	Amniotic constriction ring (HP:0009775)	2.27667658
53	Abnormality of placental membranes (HP:0011409)	2.27667658
54	Abnormality of the intrinsic pathway (HP:0010989)	2.22489102
55	Abnormality of DNA repair (HP:0003254)	2.19699688
56	Dysostosis multiplex (HP:0000943)	2.19549140
57	Entropion (HP:0000621)	2.19175421
58	Panhypogammaglobulinemia (HP:0003139)	2.17557141
59	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.14875605
60	Aplasia of the musculature (HP:0100854)	2.13892244
61	Ragged-red muscle fibers (HP:0003200)	2.13725017
62	Abnormality of the prostate (HP:0008775)	2.13538545
63	Hemorrhage of the eye (HP:0011885)	2.13157695
64	Basal cell carcinoma (HP:0002671)	2.13072260
65	Patellar aplasia (HP:0006443)	2.10640460
66	Fatigue (HP:0012378)	2.09978037
67	Prostate neoplasm (HP:0100787)	2.09733354
68	T lymphocytopenia (HP:0005403)	2.07788191
69	Aplasia/Hypoplasia of the patella (HP:0006498)	2.07284412
70	Increased serum lactate (HP:0002151)	2.06320349
71	Cheilitis (HP:0100825)	2.04548121
72	Combined immunodeficiency (HP:0005387)	2.04296888
73	Abnormality of T cell number (HP:0011839)	2.01730578
74	Decreased central vision (HP:0007663)	1.96842002
75	Progressive microcephaly (HP:0000253)	1.96752610
76	Persistence of primary teeth (HP:0006335)	1.96730682
77	Choroideremia (HP:0001139)	1.94108543
78	IgA deficiency (HP:0002720)	1.93292294
79	Duplicated collecting system (HP:0000081)	1.92545497
80	Pancytopenia (HP:0001876)	1.90982332
81	Cerebellar dysplasia (HP:0007033)	1.89881205
82	Gastrointestinal infarctions (HP:0005244)	1.89635607
83	Anorexia (HP:0002039)	1.88768030
84	Recurrent fungal infections (HP:0002841)	1.87010186
85	Myositis (HP:0100614)	1.86823338
86	Reduced antithrombin III activity (HP:0001976)	1.85443731
87	Exertional dyspnea (HP:0002875)	1.84875819
88	Conical tooth (HP:0000698)	1.84556822
89	Opisthotonus (HP:0002179)	1.83009247
90	Increased IgM level (HP:0003496)	1.82386901
91	Popliteal pterygium (HP:0009756)	1.82337317
92	Joint hemorrhage (HP:0005261)	1.82163567
93	Hypergonadotropic hypogonadism (HP:0000815)	1.81724826
94	Stomatitis (HP:0010280)	1.79023118
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.77956720
96	Stomach cancer (HP:0012126)	1.77116429
97	Granulocytopenia (HP:0001913)	1.76333759
98	Clumsiness (HP:0002312)	1.76178675
99	Abnormal spermatogenesis (HP:0008669)	1.75913460
100	Epiphyseal stippling (HP:0010655)	1.74931220

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.30512469
2	TESK2	4.26351961
3	TAOK3	3.53191231
4	TXK	3.37479669
5	ZAK	3.18535765
6	VRK2	3.01810099
7	MAP3K14	2.87499173
8	MUSK	2.84121452
9	GRK6	2.66671289
10	MAP2K2	2.66040042
11	IRAK3	2.51859571
12	NEK1	2.41297874
13	TBK1	2.22097541
14	MAPK15	2.18990887
15	STK16	1.91997177
16	IKBKB	1.88577477
17	MAPKAPK3	1.74580704
18	MAP4K1	1.64114142
19	MAP4K2	1.59248432
20	BCKDK	1.57879455
21	WNK4	1.52554727
22	NUAK1	1.51214694
23	IKBKE	1.48260619
24	BUB1	1.45648448
25	NME2	1.43532228
26	KDR	1.39266042
27	CDK8	1.30821518
28	CCNB1	1.23312080
29	CDK4	1.20837569
30	KIT	1.18775796
31	SRPK1	1.16762288
32	VRK1	1.10993129
33	ZAP70	1.08999825
34	STK10	1.08757183
35	CSF1R	1.07289032
36	PDK2	1.03843641
37	MAP2K3	0.91845603
38	EIF2AK2	0.91702358
39	MAPK11	0.91518974
40	SIK2	0.91216098
41	FES	0.88903814
42	DAPK1	0.85422345
43	NEK2	0.80871842
44	JAK3	0.80176998
45	EPHA2	0.78390508
46	AURKA	0.77748373
47	MST4	0.76484969
48	SCYL2	0.74703732
49	ADRBK2	0.74560121
50	CHEK2	0.72726579
51	PIM2	0.72227831
52	EEF2K	0.71959643
53	SYK	0.71825450
54	MATK	0.71486196
55	RPS6KA5	0.70096965
56	ITK	0.69811318
57	CHUK	0.68727876
58	ATR	0.66501529
59	TEC	0.64643798
60	RPS6KA2	0.62592148
61	BLK	0.61956949
62	SMG1	0.60303149
63	FLT3	0.59567711
64	MAP2K6	0.57959292
65	EIF2AK3	0.56577588
66	LCK	0.56443526
67	PIM1	0.55927705
68	BTK	0.53760057
69	JAK1	0.52641410
70	LYN	0.51626688
71	LIMK1	0.48675886
72	TRPM7	0.45423904
73	ERN1	0.45190636
74	MAPKAPK2	0.43470353
75	RPS6KB2	0.43401117
76	OXSR1	0.42035206
77	MAP2K1	0.41437427
78	AURKB	0.41335070
79	MAP3K13	0.40788703
80	TRIB3	0.39138137
81	BMPR2	0.38551590
82	MAPKAPK5	0.37409526
83	PRKCI	0.36712920
84	GRK1	0.35239861
85	ADRBK1	0.32625351
86	BRD4	0.32525757
87	CDK7	0.32210651
88	HCK	0.32042448
89	PRKD2	0.31620006
90	CDK6	0.30667224
91	MST1R	0.30358178
92	ABL1	0.29769436
93	PBK	0.29743262
94	PLK1	0.29648101
95	RPS6KA1	0.29551361
96	PRKCQ	0.28926573
97	IRAK4	0.26440962
98	PHKG2	0.25945361
99	PHKG1	0.25945361
100	PDPK1	0.25508467

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.61518093
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.81060846
3	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.71415708
4	Sulfur relay system_Homo sapiens_hsa04122	2.67744795
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.64058005
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.63843910
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.51264333
8	RNA polymerase_Homo sapiens_hsa03020	2.47648583
9	DNA replication_Homo sapiens_hsa03030	2.32200821
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.26746849
11	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.25213279
12	Asthma_Homo sapiens_hsa05310	2.16047658
13	Base excision repair_Homo sapiens_hsa03410	2.15094455
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.09916705
15	Graft-versus-host disease_Homo sapiens_hsa05332	2.02926452
16	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.98863281
17	Allograft rejection_Homo sapiens_hsa05330	1.97968326
18	Homologous recombination_Homo sapiens_hsa03440	1.90393468
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84644044
20	Proteasome_Homo sapiens_hsa03050	1.84249065
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.81448021
22	One carbon pool by folate_Homo sapiens_hsa00670	1.77361237
23	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.74388426
24	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.74269186
25	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.73686501
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.60448007
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.58919748
28	Antigen processing and presentation_Homo sapiens_hsa04612	1.53837417
29	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.53625317
30	Basal transcription factors_Homo sapiens_hsa03022	1.45980118
31	Herpes simplex infection_Homo sapiens_hsa05168	1.43886207
32	Other glycan degradation_Homo sapiens_hsa00511	1.42774711
33	Sulfur metabolism_Homo sapiens_hsa00920	1.37550517
34	RNA degradation_Homo sapiens_hsa03018	1.36611703
35	Nucleotide excision repair_Homo sapiens_hsa03420	1.36349066
36	Spliceosome_Homo sapiens_hsa03040	1.30243250
37	RNA transport_Homo sapiens_hsa03013	1.29130191
38	Mismatch repair_Homo sapiens_hsa03430	1.28582468
39	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.27633271
40	Type I diabetes mellitus_Homo sapiens_hsa04940	1.24310077
41	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.21992648
42	Leishmaniasis_Homo sapiens_hsa05140	1.17658678
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.13586902
44	Non-homologous end-joining_Homo sapiens_hsa03450	1.10855677
45	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.03695507
46	Rheumatoid arthritis_Homo sapiens_hsa05323	1.03389668
47	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.03272488
48	Viral myocarditis_Homo sapiens_hsa05416	0.96331314
49	Apoptosis_Homo sapiens_hsa04210	0.93401768
50	Purine metabolism_Homo sapiens_hsa00230	0.87448928
51	Measles_Homo sapiens_hsa05162	0.87300357
52	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.86028261
53	Legionellosis_Homo sapiens_hsa05134	0.84732004
54	Lysosome_Homo sapiens_hsa04142	0.84235909
55	TNF signaling pathway_Homo sapiens_hsa04668	0.82464616
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80456023
57	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.76334118
58	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.75315625
59	Influenza A_Homo sapiens_hsa05164	0.72760645
60	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72031523
61	Viral carcinogenesis_Homo sapiens_hsa05203	0.71606141
62	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.69893551
63	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.68961795
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.68873268
65	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.67628529
66	Osteoclast differentiation_Homo sapiens_hsa04380	0.67363215
67	HTLV-I infection_Homo sapiens_hsa05166	0.67268689
68	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66577108
69	Sphingolipid metabolism_Homo sapiens_hsa00600	0.65489944
70	Toxoplasmosis_Homo sapiens_hsa05145	0.65452668
71	Shigellosis_Homo sapiens_hsa05131	0.65201339
72	Cell cycle_Homo sapiens_hsa04110	0.62013339
73	p53 signaling pathway_Homo sapiens_hsa04115	0.60232749
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58980318
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57850673
76	Tuberculosis_Homo sapiens_hsa05152	0.53548278
77	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.49731915
78	Hepatitis B_Homo sapiens_hsa05161	0.43023772
79	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42304407
80	Circadian rhythm_Homo sapiens_hsa04710	0.39419806
81	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.38884928
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.38862193
83	Phototransduction_Homo sapiens_hsa04744	0.35594530
84	Hepatitis C_Homo sapiens_hsa05160	0.35395154
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34678524
86	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.34320359
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32456505
88	Regulation of autophagy_Homo sapiens_hsa04140	0.31897559
89	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.29362413
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.29284765
91	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29009209
92	Metabolic pathways_Homo sapiens_hsa01100	0.25049566
93	Bladder cancer_Homo sapiens_hsa05219	0.22851922
94	Pertussis_Homo sapiens_hsa05133	0.22245565
95	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.20515275
96	Endocytosis_Homo sapiens_hsa04144	0.20111325
97	Alcoholism_Homo sapiens_hsa05034	0.19670174
98	Nitrogen metabolism_Homo sapiens_hsa00910	0.17223345
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.17086715
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.15868896

SENP3-EIF4A1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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