SENP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.74160138
2cell adhesion mediated by integrin (GO:0033627)4.32969358
3insulin-like growth factor receptor signaling pathway (GO:0048009)3.84168649
4RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.77197528
5plasma membrane repair (GO:0001778)3.72735408
6synapsis (GO:0007129)3.70392175
7DNA double-strand break processing (GO:0000729)3.69277930
8negative regulation of fatty acid transport (GO:2000192)3.68354303
9water-soluble vitamin biosynthetic process (GO:0042364)3.64379018
10response to pheromone (GO:0019236)3.58958254
11layer formation in cerebral cortex (GO:0021819)3.50040887
12piRNA metabolic process (GO:0034587)3.49671790
13regulation of DNA endoreduplication (GO:0032875)3.49359664
14protein K6-linked ubiquitination (GO:0085020)3.44955597
15behavioral response to nicotine (GO:0035095)3.43817128
16regulation of mesoderm development (GO:2000380)3.31870949
17cytoplasmic mRNA processing body assembly (GO:0033962)3.30889372
18neuron projection extension involved in neuron projection guidance (GO:1902284)3.28328671
19axon extension involved in axon guidance (GO:0048846)3.28328671
20protein polyglutamylation (GO:0018095)3.28122029
21replication fork processing (GO:0031297)3.28088320
22prostate gland growth (GO:0060736)3.25146286
23platelet dense granule organization (GO:0060155)3.21761090
24double-strand break repair via homologous recombination (GO:0000724)3.19606867
25L-fucose catabolic process (GO:0042355)3.19190982
26fucose catabolic process (GO:0019317)3.19190982
27L-fucose metabolic process (GO:0042354)3.19190982
28recombinational repair (GO:0000725)3.18428466
29positive regulation of fibroblast migration (GO:0010763)3.14663664
30regulation of clathrin-mediated endocytosis (GO:2000369)3.14581843
31protein K11-linked deubiquitination (GO:0035871)3.13962839
32negative regulation of DNA-dependent DNA replication (GO:2000104)3.10812878
33synaptic vesicle maturation (GO:0016188)3.09022786
34regulation of translational termination (GO:0006449)3.07027806
35DNA methylation involved in gamete generation (GO:0043046)3.05749422
36regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.04848326
37somite development (GO:0061053)3.02629162
38keratinocyte development (GO:0003334)3.01690867
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01679994
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01453361
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99918113
42NLS-bearing protein import into nucleus (GO:0006607)2.99739489
43preassembly of GPI anchor in ER membrane (GO:0016254)2.97435887
44cytoskeletal anchoring at plasma membrane (GO:0007016)2.93475809
45vesicle transport along microtubule (GO:0047496)2.93223850
46chondrocyte proliferation (GO:0035988)2.91151310
47limb bud formation (GO:0060174)2.90964008
48neural tube formation (GO:0001841)2.88678119
49nuclear pore complex assembly (GO:0051292)2.87497722
50respiratory chain complex IV assembly (GO:0008535)2.87255673
51collagen fibril organization (GO:0030199)2.85835033
52somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85318421
53isotype switching (GO:0045190)2.85318421
54somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85318421
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84754953
56mitochondrial respiratory chain complex I assembly (GO:0032981)2.84754953
57NADH dehydrogenase complex assembly (GO:0010257)2.84754953
58rRNA catabolic process (GO:0016075)2.83646879
59protein complex biogenesis (GO:0070271)2.83471132
60regulation of glucokinase activity (GO:0033131)2.82961901
61regulation of hexokinase activity (GO:1903299)2.82961901
62regulation of meiosis I (GO:0060631)2.81845697
63stress fiber assembly (GO:0043149)2.80753223
64regulation of hippo signaling (GO:0035330)2.80155394
65kidney morphogenesis (GO:0060993)2.77936116
66regulation of NFAT protein import into nucleus (GO:0051532)2.77302273
67establishment of nucleus localization (GO:0040023)2.76206006
68proteasome assembly (GO:0043248)2.75593444
69locomotory exploration behavior (GO:0035641)2.75264225
70regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74867665
71negative regulation of telomere maintenance (GO:0032205)2.74631305
72axon extension (GO:0048675)2.73578474
73protein-cofactor linkage (GO:0018065)2.73191750
74detection of light stimulus involved in visual perception (GO:0050908)2.72123629
75detection of light stimulus involved in sensory perception (GO:0050962)2.72123629
76inositol phosphate catabolic process (GO:0071545)2.70524596
77indolalkylamine metabolic process (GO:0006586)2.70390577
78tryptophan catabolic process (GO:0006569)2.66744086
79indole-containing compound catabolic process (GO:0042436)2.66744086
80indolalkylamine catabolic process (GO:0046218)2.66744086
81mannosylation (GO:0097502)2.66360948
82regulation of tight junction assembly (GO:2000810)2.66044455
83endodermal cell differentiation (GO:0035987)2.65808320
84hippo signaling (GO:0035329)2.65601819
85regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.64224375
86clathrin coat assembly (GO:0048268)2.64001561
87male meiosis I (GO:0007141)2.63399662
88regulation of mitotic spindle organization (GO:0060236)2.62847941
89mitochondrial respiratory chain complex assembly (GO:0033108)2.62814645
90substrate-dependent cell migration (GO:0006929)2.62242542
91stress granule assembly (GO:0034063)2.62238687
92kynurenine metabolic process (GO:0070189)2.61152812
93male meiosis (GO:0007140)2.59184842
94neuron projection extension (GO:1990138)2.58650334
95ketone body metabolic process (GO:1902224)2.58454920
96reciprocal DNA recombination (GO:0035825)2.56976287
97reciprocal meiotic recombination (GO:0007131)2.56976287
98protein localization to cilium (GO:0061512)2.55574226
99cornea development in camera-type eye (GO:0061303)2.54417779
100synaptic vesicle docking involved in exocytosis (GO:0016081)2.53635453
101sulfation (GO:0051923)2.53545901
102embryonic epithelial tube formation (GO:0001838)2.51848561
103tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51200342
104RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51200342
105sequestering of extracellular ligand from receptor (GO:0035581)2.51052955
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.50889023
107glucocorticoid receptor signaling pathway (GO:0042921)2.49852639
108proline transport (GO:0015824)2.49762442
109magnesium ion transport (GO:0015693)2.49522150
110negative regulation of mast cell activation (GO:0033004)2.48812704
111axoneme assembly (GO:0035082)2.48357178
112resolution of meiotic recombination intermediates (GO:0000712)2.47506473
113prenylation (GO:0097354)2.46339039
114protein prenylation (GO:0018342)2.46339039
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46303044
116cellular ketone body metabolic process (GO:0046950)2.45354789
117regulation of action potential (GO:0098900)2.45160778
1183-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.44731304
119purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.44731304
120positive regulation of oligodendrocyte differentiation (GO:0048714)2.44051264
121GPI anchor metabolic process (GO:0006505)2.43411971
122cytochrome complex assembly (GO:0017004)2.42591212
123cortical actin cytoskeleton organization (GO:0030866)2.42235346
124positive regulation of protein autophosphorylation (GO:0031954)2.40978871
125regulation of rhodopsin mediated signaling pathway (GO:0022400)2.40442013
126serotonin metabolic process (GO:0042428)2.39379439
127organelle transport along microtubule (GO:0072384)2.39005291
128somatic hypermutation of immunoglobulin genes (GO:0016446)2.38124329
129somatic diversification of immune receptors via somatic mutation (GO:0002566)2.38124329
130peptidyl-lysine dimethylation (GO:0018027)2.37300951
131nuclear pore organization (GO:0006999)2.36833530
132endoderm formation (GO:0001706)2.36784236
133somatic diversification of immunoglobulins (GO:0016445)2.35927482
134histone H2A acetylation (GO:0043968)2.35883101
135epithelial cilium movement (GO:0003351)2.35841871
136vesicle coating (GO:0006901)2.35646315
137semaphorin-plexin signaling pathway (GO:0071526)2.35559094
138regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.35293061
139regulation of polysaccharide biosynthetic process (GO:0032885)2.35262827
140DNA catabolic process, exonucleolytic (GO:0000738)2.35076824
141macroautophagy (GO:0016236)2.35014907
142protein localization to endosome (GO:0036010)2.34901775
143indole-containing compound metabolic process (GO:0042430)2.34459214
144endocytic recycling (GO:0032456)2.34251573
145microtubule anchoring (GO:0034453)2.34237152
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33929653
147negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.33373730
148retinal cone cell development (GO:0046549)2.33004607
149regulation of short-term neuronal synaptic plasticity (GO:0048172)2.32579920
150regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.32080505
151regulation of ARF protein signal transduction (GO:0032012)2.31716578
152regulation of membrane protein ectodomain proteolysis (GO:0051043)2.30505045
153Golgi transport vesicle coating (GO:0048200)2.30170829
154COPI coating of Golgi vesicle (GO:0048205)2.30170829
155positive regulation of glycogen biosynthetic process (GO:0045725)2.29813569
156corticosteroid receptor signaling pathway (GO:0031958)2.28695147
157regulation of nucleobase-containing compound transport (GO:0032239)2.28572672
158axonal fasciculation (GO:0007413)2.27023037
159growth hormone receptor signaling pathway (GO:0060396)2.26243037
160regulation of early endosome to late endosome transport (GO:2000641)2.25316961
161apoptotic cell clearance (GO:0043277)2.24889422
162pre-miRNA processing (GO:0031054)2.24792205
163regulation of RNA export from nucleus (GO:0046831)2.24017329
164heparan sulfate proteoglycan metabolic process (GO:0030201)2.23972603
165positive regulation of axon extension (GO:0045773)2.22664975
166nerve growth factor signaling pathway (GO:0038180)2.22611466
167dendrite morphogenesis (GO:0048813)2.22215308
168regulation of glycogen (starch) synthase activity (GO:2000465)2.21980013
169peptidyl-threonine phosphorylation (GO:0018107)2.21418444
170heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.19090371
171adherens junction assembly (GO:0034333)2.16749746
172pore complex assembly (GO:0046931)2.16191886
173regulation of spindle organization (GO:0090224)2.15306232
174peptidyl-threonine modification (GO:0018210)2.14066902
175positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.12290037
176platelet-derived growth factor receptor signaling pathway (GO:0048008)2.12119480
177activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.11949840
178positive regulation of macrophage cytokine production (GO:0060907)2.11654121
179positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.11562315
180activation of protein kinase A activity (GO:0034199)2.11409613
181histone H2A monoubiquitination (GO:0035518)2.11058397
182actin filament bundle organization (GO:0061572)2.09939357
183actin filament bundle assembly (GO:0051017)2.09939357
184adherens junction organization (GO:0034332)2.09682258
185skin morphogenesis (GO:0043589)2.09429713
186metanephric mesenchyme development (GO:0072075)2.09199453
187cerebellar Purkinje cell layer development (GO:0021680)2.08909938
188membrane budding (GO:0006900)2.07720697
189neuromuscular process controlling balance (GO:0050885)2.07282815
190cytoskeleton-dependent cytokinesis (GO:0061640)2.06993517
191developmental cell growth (GO:0048588)2.06734473
192positive regulation of macroautophagy (GO:0016239)2.05467084
193negative regulation of lipid transport (GO:0032369)2.04859413
194positive regulation of histone deacetylation (GO:0031065)2.04705286
195mitotic sister chromatid cohesion (GO:0007064)2.04426995
196activation of MAPKK activity (GO:0000186)2.04135863
197regulation of macrophage cytokine production (GO:0010935)2.03127177
198endoplasmic reticulum organization (GO:0007029)2.02656839
199germ cell migration (GO:0008354)2.01826599
200protein heterotrimerization (GO:0070208)1.99717788

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.28328982
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.37722749
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.78066956
4VDR_22108803_ChIP-Seq_LS180_Human2.77916503
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68564510
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.53617352
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39839390
8TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.36561682
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35287280
10FUS_26573619_Chip-Seq_HEK293_Human2.34504769
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.33602743
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32757848
13EWS_26573619_Chip-Seq_HEK293_Human2.31199128
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29369370
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.27366463
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20541481
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.18754731
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.12458373
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.11501866
20P300_19829295_ChIP-Seq_ESCs_Human2.11232254
21TAF15_26573619_Chip-Seq_HEK293_Human2.09561852
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08175538
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.06585137
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04716274
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04220674
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.03921586
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94453117
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90730998
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.90641341
30* IGF1R_20145208_ChIP-Seq_DFB_Human1.88270035
31TP53_16413492_ChIP-PET_HCT116_Human1.88022420
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84005525
33CLOCK_20551151_ChIP-Seq_293T_Human1.83054024
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80948655
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.79405015
36* ER_23166858_ChIP-Seq_MCF-7_Human1.78845135
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75349981
38ELK1_19687146_ChIP-ChIP_HELA_Human1.75182273
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.73075328
40BRD4_25478319_ChIP-Seq_HGPS_Human1.66677772
41P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64091200
42ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63380553
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.63194683
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63091794
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59885637
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59799852
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57798596
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57592907
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57065685
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52143283
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.52089044
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51730081
53CJUN_26792858_Chip-Seq_BT549_Human1.51130092
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.49910865
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49491358
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48431053
57CBP_20019798_ChIP-Seq_JUKART_Human1.48426568
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48426568
59* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48344707
60RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.47770602
61* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46677035
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46330852
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46078984
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45860304
65BCAT_22108803_ChIP-Seq_LS180_Human1.45069075
66MYC_18940864_ChIP-ChIP_HL60_Human1.43586450
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.41140135
68DROSHA_22980978_ChIP-Seq_HELA_Human1.40452291
69* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.39509124
70* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.39509124
71IRF1_19129219_ChIP-ChIP_H3396_Human1.39424107
72RXR_22108803_ChIP-Seq_LS180_Human1.39183137
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39145074
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.38877606
75AR_25329375_ChIP-Seq_VCAP_Human1.38782505
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38780054
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38614630
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38424233
79* TCF4_23295773_ChIP-Seq_U87_Human1.37886359
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37627531
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37433303
82KDM2B_26808549_Chip-Seq_DND41_Human1.37272864
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37252280
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36439142
85TP53_22573176_ChIP-Seq_HFKS_Human1.35986685
86* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35257786
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34557175
88FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.33843577
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33678622
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33678622
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31958290
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30720911
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.30228612
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30031205
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29848903
96VDR_23849224_ChIP-Seq_CD4+_Human1.28723558
97* NANOG_19829295_ChIP-Seq_ESCs_Human1.27526791
98* SOX2_19829295_ChIP-Seq_ESCs_Human1.27526791
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27296886
100AHR_22903824_ChIP-Seq_MCF-7_Human1.26074300
101KDM2B_26808549_Chip-Seq_K562_Human1.26030440
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.26029193
103ZNF274_21170338_ChIP-Seq_K562_Hela1.25643821
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24617785
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24162669
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22978452
107P53_22387025_ChIP-Seq_ESCs_Mouse1.22634641
108SOX2_21211035_ChIP-Seq_LN229_Gbm1.22550391
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21861375
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21099010
111TCF4_22108803_ChIP-Seq_LS180_Human1.21069833
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20945610
113EZH2_22144423_ChIP-Seq_EOC_Human1.20941859
114RARB_27405468_Chip-Seq_BRAIN_Mouse1.20061372
115SMAD4_21799915_ChIP-Seq_A2780_Human1.19242116
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19075179
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18749526
118TP53_18474530_ChIP-ChIP_U2OS_Human1.18283551
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18094533
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18024836
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18003394
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.17771572
123CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17671446
124POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17216500
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.16310343
126PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16137610
127ESR1_20079471_ChIP-ChIP_T-47D_Human1.15491828
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.15358793
129CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14390842
130* STAT3_23295773_ChIP-Seq_U87_Human1.14244831
131RNF2_27304074_Chip-Seq_NSC_Mouse1.14124071
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13807711
133GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13226947
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13039238
135E2F1_18555785_Chip-Seq_ESCs_Mouse1.12992906
136* FOXA2_19822575_ChIP-Seq_HepG2_Human1.11803246
137* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11447058
138STAT3_18555785_Chip-Seq_ESCs_Mouse1.10739295
139CDX2_22108803_ChIP-Seq_LS180_Human1.10613196
140FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10099082
141SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09801647
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08946173
143RUNX2_22187159_ChIP-Seq_PCA_Human1.08781544
144FOXA1_25329375_ChIP-Seq_VCAP_Human1.08357218
145FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08357218
146RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08255370
147PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07775478
148* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07536013
149AR_19668381_ChIP-Seq_PC3_Human1.07048759
150ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06468562
151P300_18555785_Chip-Seq_ESCs_Mouse1.06045056
152CMYC_18555785_Chip-Seq_ESCs_Mouse1.05647589
153VDR_24787735_ChIP-Seq_THP-1_Human1.05607745
154ARNT_22903824_ChIP-Seq_MCF-7_Human1.05450240
155KDM2B_26808549_Chip-Seq_JURKAT_Human1.04575852
156ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04293625
157TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03642140
158FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03429078
159EP300_21415370_ChIP-Seq_HL-1_Mouse1.02715938
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02370217
161KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02358378
162PRDM14_20953172_ChIP-Seq_ESCs_Human1.01539206
163UBF1/2_26484160_Chip-Seq_HMECs_Human1.01265899
164AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00641846
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00506339
166EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00390870
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99260747
168OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98092105
169KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97413513
170RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97061670
171EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97061670
172STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96739776
173TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94515756
174ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94268891
175OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93663451
176PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93492160
177STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93292588
178PIAS1_25552417_ChIP-Seq_VCAP_Human0.93001651
179NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92883393
180GBX2_23144817_ChIP-Seq_PC3_Human0.92598028
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91755999
182YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91233194
183BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90753907
184* ATF3_27146783_Chip-Seq_COLON_Human0.90214378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.17865223
2MP0008438_abnormal_cutaneous_collagen4.23977698
3MP0003705_abnormal_hypodermis_morpholog4.13474211
4MP0002102_abnormal_ear_morphology3.55546181
5MP0003195_calcinosis3.47406681
6MP0005623_abnormal_meninges_morphology3.36921579
7MP0004859_abnormal_synaptic_plasticity3.13762786
8MP0010352_gastrointestinal_tract_polyps3.11082837
9MP0003091_abnormal_cell_migration3.07020565
10MP0000372_irregular_coat_pigmentation3.06620295
11MP0008877_abnormal_DNA_methylation3.04942518
12MP0003300_gastrointestinal_ulcer2.70740770
13MP0002837_dystrophic_cardiac_calcinosis2.61915790
14MP0005646_abnormal_pituitary_gland2.49871475
15MP0002877_abnormal_melanocyte_morpholog2.45664348
16MP0005076_abnormal_cell_differentiation2.40435990
17MP0001299_abnormal_eye_distance/2.31307558
18MP0005503_abnormal_tendon_morphology2.25209800
19MP0000733_abnormal_muscle_development2.23880134
20MP0009780_abnormal_chondrocyte_physiolo2.21644677
21MP0003283_abnormal_digestive_organ2.08179686
22MP0001348_abnormal_lacrimal_gland2.02445970
23MP0003566_abnormal_cell_adhesion2.01208008
24MP0005551_abnormal_eye_electrophysiolog2.00722045
25MP0002160_abnormal_reproductive_system1.94650872
26MP0006292_abnormal_olfactory_placode1.90506325
27MP0008058_abnormal_DNA_repair1.89404974
28MP0002876_abnormal_thyroid_physiology1.89106336
29MP0005275_abnormal_skin_tensile1.87966314
30MP0001485_abnormal_pinna_reflex1.86043340
31MP0005174_abnormal_tail_pigmentation1.85646694
32MP0000427_abnormal_hair_cycle1.78611656
33MP0009053_abnormal_anal_canal1.77290232
34MP0010307_abnormal_tumor_latency1.76228276
35MP0003646_muscle_fatigue1.71328308
36MP0002638_abnormal_pupillary_reflex1.70695888
37MP0002736_abnormal_nociception_after1.69248495
38MP0004885_abnormal_endolymph1.67972375
39MP0003045_fibrosis1.64094636
40MP0008057_abnormal_DNA_replication1.61570203
41MP0005389_reproductive_system_phenotype1.60834396
42MP0005253_abnormal_eye_physiology1.60652815
43MP0003880_abnormal_central_pattern1.60524665
44MP0006072_abnormal_retinal_apoptosis1.60196694
45MP0000015_abnormal_ear_pigmentation1.58787440
46MP0003172_abnormal_lysosome_physiology1.56498716
47MP0002938_white_spotting1.56371181
48MP0000383_abnormal_hair_follicle1.55796227
49MP0003787_abnormal_imprinting1.52577076
50MP0010234_abnormal_vibrissa_follicle1.49832809
51MP0003279_aneurysm1.49456197
52MP0003303_peritoneal_inflammation1.47692789
53MP0005257_abnormal_intraocular_pressure1.44874346
54MP0008872_abnormal_physiological_respon1.44140155
55MP0005367_renal/urinary_system_phenotyp1.42939739
56MP0000516_abnormal_urinary_system1.42939739
57MP0005075_abnormal_melanosome_morpholog1.41657610
58MP0000631_abnormal_neuroendocrine_gland1.41473064
59MP0009745_abnormal_behavioral_response1.40274127
60MP0003119_abnormal_digestive_system1.40112144
61MP0003718_maternal_effect1.39904632
62MP0002751_abnormal_autonomic_nervous1.39388347
63MP0001486_abnormal_startle_reflex1.36706664
64MP0005645_abnormal_hypothalamus_physiol1.35327368
65MP0010094_abnormal_chromosome_stability1.34070805
66MP0010678_abnormal_skin_adnexa1.32605190
67MP0002272_abnormal_nervous_system1.31629798
68MP0004510_myositis1.30712950
69MP0001986_abnormal_taste_sensitivity1.30246981
70MP0004133_heterotaxia1.27758313
71MP0003121_genomic_imprinting1.27402690
72MP0004272_abnormal_basement_membrane1.26654358
73MP0005023_abnormal_wound_healing1.26625082
74MP0006054_spinal_hemorrhage1.25111783
75MP0005187_abnormal_penis_morphology1.24416671
76MP0003786_premature_aging1.24399120
77MP0002095_abnormal_skin_pigmentation1.21713352
78MP0001984_abnormal_olfaction1.21271781
79MP0005248_abnormal_Harderian_gland1.21135473
80MP0000647_abnormal_sebaceous_gland1.20354059
81MP0000428_abnormal_craniofacial_morphol1.20005461
82MP0005171_absent_coat_pigmentation1.19367478
83MP0006276_abnormal_autonomic_nervous1.18060968
84MP0004142_abnormal_muscle_tone1.16298663
85MP0004147_increased_porphyrin_level1.15615208
86MP0001958_emphysema1.15593666
87MP0000604_amyloidosis1.14483801
88MP0003122_maternal_imprinting1.13339772
89MP0009384_cardiac_valve_regurgitation1.13222853
90MP0003329_amyloid_beta_deposits1.13005368
91MP0001915_intracranial_hemorrhage1.09114280
92MP0000013_abnormal_adipose_tissue1.08733112
93MP0004811_abnormal_neuron_physiology1.07529489
94MP0002282_abnormal_trachea_morphology1.07283752
95MP0004270_analgesia1.07188550
96MP0005508_abnormal_skeleton_morphology1.06298217
97MP0003385_abnormal_body_wall1.04843304
98MP0002168_other_aberrant_phenotype1.04372294
99MP0002896_abnormal_bone_mineralization1.03919057
100MP0000003_abnormal_adipose_tissue1.03359826
101MP0004185_abnormal_adipocyte_glucose1.03044241
102MP0001929_abnormal_gametogenesis1.02501603
103MP0003136_yellow_coat_color1.02280673
104MP0001293_anophthalmia1.01747365
105MP0001919_abnormal_reproductive_system1.01474986
106MP0008961_abnormal_basal_metabolism1.01430211
107MP0004197_abnormal_fetal_growth/weight/1.01073325
108MP0004858_abnormal_nervous_system0.97862968
109MP0005084_abnormal_gallbladder_morpholo0.97797700
110MP0003635_abnormal_synaptic_transmissio0.97203010
111MP0003950_abnormal_plasma_membrane0.97084166
112MP0003115_abnormal_respiratory_system0.97025937
113MP0003011_delayed_dark_adaptation0.96962380
114MP0004145_abnormal_muscle_electrophysio0.96150745
115MP0005386_behavior/neurological_phenoty0.95927948
116MP0004924_abnormal_behavior0.95927948
117MP0000537_abnormal_urethra_morphology0.93550673
118MP0003252_abnormal_bile_duct0.93444100
119MP0005621_abnormal_cell_physiology0.92723230
120MP0002557_abnormal_social/conspecific_i0.92668831
121MP0002928_abnormal_bile_duct0.92587864
122MP0001324_abnormal_eye_pigmentation0.91915770
123MP0002210_abnormal_sex_determination0.91113266
124MP0004130_abnormal_muscle_cell0.90874803
125MP0000767_abnormal_smooth_muscle0.88822516
126MP0000653_abnormal_sex_gland0.88532439
127MP0005379_endocrine/exocrine_gland_phen0.88476555
128MP0004215_abnormal_myocardial_fiber0.87425756
129MP0009046_muscle_twitch0.87134927
130MP0005220_abnormal_exocrine_pancreas0.86105015
131MP0002295_abnormal_pulmonary_circulatio0.85440591
132MP0008875_abnormal_xenobiotic_pharmacok0.85201858
133MP0008995_early_reproductive_senescence0.83919736
134MP0005195_abnormal_posterior_eye0.83047979
135MP0005197_abnormal_uvea_morphology0.82877250
136MP0000534_abnormal_ureter_morphology0.82276964
137MP0002932_abnormal_joint_morphology0.81971690
138MP0008775_abnormal_heart_ventricle0.81381325
139MP0003755_abnormal_palate_morphology0.80805863
140MP0001145_abnormal_male_reproductive0.80641932
141MP0002184_abnormal_innervation0.80286673
142MP0003693_abnormal_embryo_hatching0.80231752
143MP0002735_abnormal_chemical_nociception0.79816120
144MP0002234_abnormal_pharynx_morphology0.79584522
145MP0005408_hypopigmentation0.79147666
146MP0002138_abnormal_hepatobiliary_system0.78676247
147MP0001119_abnormal_female_reproductive0.78489755
148MP0003698_abnormal_male_reproductive0.77478139
149MP0002064_seizures0.77316470
150MP0003890_abnormal_embryonic-extraembry0.76698605
151MP0002090_abnormal_vision0.76331260
152MP0002086_abnormal_extraembryonic_tissu0.76145637
153MP0003123_paternal_imprinting0.75391939
154MP0002572_abnormal_emotion/affect_behav0.75199668
155MP0001243_abnormal_dermal_layer0.73883069
156MP0003935_abnormal_craniofacial_develop0.73317044
157MP0002108_abnormal_muscle_morphology0.73295497
158MP0004947_skin_inflammation0.73266681
159MP0004808_abnormal_hematopoietic_stem0.72889316
160MP0002163_abnormal_gland_morphology0.72269102
161MP0002084_abnormal_developmental_patter0.71577683
162MP0000778_abnormal_nervous_system0.71487679
163MP0003632_abnormal_nervous_system0.71268351
164MP0004085_abnormal_heartbeat0.71045714
165MP0002733_abnormal_thermal_nociception0.71006072
166MP0003938_abnormal_ear_development0.70685479
167MP0010030_abnormal_orbit_morphology0.69326001
168MP0002925_abnormal_cardiovascular_devel0.68466019
169MP0001440_abnormal_grooming_behavior0.68210391
170MP0000350_abnormal_cell_proliferation0.67608793
171MP0004134_abnormal_chest_morphology0.67572902
172MP0001968_abnormal_touch/_nociception0.67358346
173MP0002998_abnormal_bone_remodeling0.66690225
174MP0005375_adipose_tissue_phenotype0.65221796
175MP0000747_muscle_weakness0.63970329
176MP0002177_abnormal_outer_ear0.63909517
177MP0002909_abnormal_adrenal_gland0.63842399
178MP0005390_skeleton_phenotype0.63818520
179MP0005384_cellular_phenotype0.63208265
180MP0002088_abnormal_embryonic_growth/wei0.63142425
181MP0001346_abnormal_lacrimal_gland0.61644962
182MP0003937_abnormal_limbs/digits/tail_de0.60919908
183MP0003984_embryonic_growth_retardation0.60788499
184MP0002063_abnormal_learning/memory/cond0.60322514
185MP0003448_altered_tumor_morphology0.60072863
186MP0000955_abnormal_spinal_cord0.59698632

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.14775153
2Premature rupture of membranes (HP:0001788)4.07131612
3Pancreatic cysts (HP:0001737)3.87830008
4Shallow orbits (HP:0000586)3.48320980
5Pancreatic fibrosis (HP:0100732)3.33228269
6Dilatation of the ascending aorta (HP:0005111)3.32232707
7Congenital stationary night blindness (HP:0007642)3.23407841
8Abnormality of midbrain morphology (HP:0002418)3.22984373
9Molar tooth sign on MRI (HP:0002419)3.22984373
10True hermaphroditism (HP:0010459)3.19099227
11Increased density of long bones (HP:0006392)3.12754427
12Cerebral aneurysm (HP:0004944)3.07485797
13Abnormality of the renal cortex (HP:0011035)3.00862914
14Absent frontal sinuses (HP:0002688)2.99479112
15Nephronophthisis (HP:0000090)2.99301602
16Aortic dissection (HP:0002647)2.95027960
17Subacute progressive viral hepatitis (HP:0006572)2.90208485
18Aortic aneurysm (HP:0004942)2.86077721
19Peritonitis (HP:0002586)2.77694079
20Renal cortical cysts (HP:0000803)2.72763439
21Macroorchidism (HP:0000053)2.72248958
22Lower limb amyotrophy (HP:0007210)2.70503166
23Mitral valve prolapse (HP:0001634)2.68495766
24Insidious onset (HP:0003587)2.66818766
25Termporal pattern (HP:0011008)2.66818766
26Arterial tortuosity (HP:0005116)2.64690731
27Abnormality of the renal medulla (HP:0100957)2.63832137
28Vascular tortuosity (HP:0004948)2.61236859
29Hypothermia (HP:0002045)2.54106046
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.53572006
31Short 1st metacarpal (HP:0010034)2.50604178
32Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.50604178
33Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47985837
34Genu recurvatum (HP:0002816)2.42180431
35Medial flaring of the eyebrow (HP:0010747)2.41789007
36Type II lissencephaly (HP:0007260)2.41208553
37Gaze-evoked nystagmus (HP:0000640)2.41069306
38Methylmalonic acidemia (HP:0002912)2.38656969
39Hypoplasia of the fovea (HP:0007750)2.36888536
40Aplasia/Hypoplasia of the fovea (HP:0008060)2.36888536
41Progressive inability to walk (HP:0002505)2.36721149
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.36024712
43Intestinal atresia (HP:0011100)2.31416122
44Pendular nystagmus (HP:0012043)2.29435184
45Abolished electroretinogram (ERG) (HP:0000550)2.28591857
46Aneurysm (HP:0002617)2.28164152
47Chromsome breakage (HP:0040012)2.28111419
48Abnormality of the proximal phalanges of the hand (HP:0009834)2.26843752
49Congenital sensorineural hearing impairment (HP:0008527)2.26282654
50Attenuation of retinal blood vessels (HP:0007843)2.25972479
51Resting tremor (HP:0002322)2.25592744
52Thyroiditis (HP:0100646)2.23052526
53Distal lower limb amyotrophy (HP:0008944)2.22177866
54Asymmetry of the thorax (HP:0001555)2.17769200
55Abnormality of alanine metabolism (HP:0010916)2.16165754
56Hyperalaninemia (HP:0003348)2.16165754
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16165754
58Abnormality of the ileum (HP:0001549)2.15982601
59Ectopic kidney (HP:0000086)2.15639522
60Abnormality of chromosome stability (HP:0003220)2.15149135
61Abnormality of the 1st metacarpal (HP:0010009)2.15141153
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.14770467
63Papilledema (HP:0001085)2.13779356
64Abnormality of the renal collecting system (HP:0004742)2.13740214
65Progressive macrocephaly (HP:0004481)2.13584454
66Tubular atrophy (HP:0000092)2.13328748
67Small hand (HP:0200055)2.12596086
68Ankyloglossia (HP:0010296)2.11912496
69Ankle contracture (HP:0006466)2.11713258
70Abnormality of oral frenula (HP:0000190)2.11665305
71Meckel diverticulum (HP:0002245)2.11152235
72Buphthalmos (HP:0000557)2.11148916
73Short tibia (HP:0005736)2.11132777
74Cervical subluxation (HP:0003308)2.10643051
75Neoplasm of the adrenal cortex (HP:0100641)2.10026977
76Striae distensae (HP:0001065)2.10026478
77Wrist flexion contracture (HP:0001239)2.08578721
78Keratoconus (HP:0000563)2.08159165
79Increased corneal curvature (HP:0100692)2.08159165
80Atrophic scars (HP:0001075)2.07262695
81Large for gestational age (HP:0001520)2.07222989
82Acute necrotizing encephalopathy (HP:0006965)2.05207378
83Furrowed tongue (HP:0000221)2.03997321
84Distal upper limb amyotrophy (HP:0007149)2.03875748
85Upper limb amyotrophy (HP:0009129)2.03875748
86Sclerocornea (HP:0000647)2.03468737
87Bowel diverticulosis (HP:0005222)2.02295944
88Increased CSF lactate (HP:0002490)2.00759152
89Inability to walk (HP:0002540)2.00589217
90Soft skin (HP:0000977)1.99267550
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.99217815
92Chorioretinal atrophy (HP:0000533)1.99102588
93Global brain atrophy (HP:0002283)1.97793429
94Thin bony cortex (HP:0002753)1.97531104
95Ependymoma (HP:0002888)1.97425820
96Abnormality of the fovea (HP:0000493)1.97214419
97Cystic liver disease (HP:0006706)1.97187068
98Short 4th metacarpal (HP:0010044)1.96925726
99Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.96925726
100Heterotopia (HP:0002282)1.96407756
101Deviation of the hallux (HP:0010051)1.95415930
102Hallux valgus (HP:0001822)1.94764098
103Hamartoma of the eye (HP:0010568)1.92924332
104Chronic hepatic failure (HP:0100626)1.92697733
105Aplasia/Hypoplasia of the spleen (HP:0010451)1.91377494
106Syringomyelia (HP:0003396)1.90492801
107Spinal cord lesions (HP:0100561)1.90492801
108Abnormality of the preputium (HP:0100587)1.90448122
109Absent thumb (HP:0009777)1.90347320
110Abnormality of the peritoneum (HP:0002585)1.89395342
111Abnormality of the labia minora (HP:0012880)1.88789732
112Adrenal hypoplasia (HP:0000835)1.88187189
113Abnormality of DNA repair (HP:0003254)1.88146176
114Bladder diverticulum (HP:0000015)1.87865216
115Male pseudohermaphroditism (HP:0000037)1.86739843
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.86168362
117Osteolytic defects of the hand bones (HP:0009699)1.86168362
118Asplenia (HP:0001746)1.85703071
119Lissencephaly (HP:0001339)1.85177268
120Glioma (HP:0009733)1.84706728
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.84675670
122Duplicated collecting system (HP:0000081)1.84320699
123Acute encephalopathy (HP:0006846)1.84096171
124Mitochondrial inheritance (HP:0001427)1.82538494
125Wormian bones (HP:0002645)1.82065699
126Astrocytoma (HP:0009592)1.82024914
127Abnormality of the astrocytes (HP:0100707)1.82024914
128Sloping forehead (HP:0000340)1.81460894
129Cortical dysplasia (HP:0002539)1.80514407
130Genital tract atresia (HP:0001827)1.80364549
131Urinary urgency (HP:0000012)1.79742505
132Hemiparesis (HP:0001269)1.79552518
133Narrow palate (HP:0000189)1.79084548
134Myocardial infarction (HP:0001658)1.78712597
135Abnormality of the pons (HP:0007361)1.78556291
136Impaired vibration sensation in the lower limbs (HP:0002166)1.78067421
137Volvulus (HP:0002580)1.77578661
138Stomach cancer (HP:0012126)1.76430278
139Hyperventilation (HP:0002883)1.76416359
140Abnormal biliary tract physiology (HP:0012439)1.76372184
141Bile duct proliferation (HP:0001408)1.76372184
142Clubbing of toes (HP:0100760)1.76127911
143Methylmalonic aciduria (HP:0012120)1.75100317
144Pointed chin (HP:0000307)1.74928424
145Turricephaly (HP:0000262)1.74718210
146Congenital primary aphakia (HP:0007707)1.74621296
147Gait imbalance (HP:0002141)1.74566147
148Long toe (HP:0010511)1.74382936
149Abnormal drinking behavior (HP:0030082)1.73502879
150Polydipsia (HP:0001959)1.73502879
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73476783
152Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.73438779
153Febrile seizures (HP:0002373)1.73285649
154Duodenal stenosis (HP:0100867)1.73139995
155Small intestinal stenosis (HP:0012848)1.73139995
156Aplasia/Hypoplasia of the hallux (HP:0008362)1.73060042
157Urinary bladder sphincter dysfunction (HP:0002839)1.72794580
158Aplasia/hypoplasia of the uterus (HP:0008684)1.72390365
159Hammertoe (HP:0001765)1.71286552
160Vaginal atresia (HP:0000148)1.71074173
161Infantile muscular hypotonia (HP:0008947)1.70562701
162Abnormality of the 4th metacarpal (HP:0010012)1.70294833
163Radial bowing (HP:0002986)1.68580356
164Blue sclerae (HP:0000592)1.68481748
165Tibial bowing (HP:0002982)1.66846139
166Focal seizures (HP:0007359)1.66284767
167Abnormality of the frontal sinuses (HP:0002687)1.66101048
168Camptodactyly of toe (HP:0001836)1.65862098
169Increased mean platelet volume (HP:0011877)1.65849787
170Disproportionate tall stature (HP:0001519)1.65438780
171Persistence of primary teeth (HP:0006335)1.65089978
172Ulnar bowing (HP:0003031)1.63797419
173Spinal cord compression (HP:0002176)1.61993664
174Hand muscle atrophy (HP:0009130)1.61562178
175Broad face (HP:0000283)1.61323987
176Scapular winging (HP:0003691)1.61071838
177Cerebral inclusion bodies (HP:0100314)1.60176878
178Deep venous thrombosis (HP:0002625)1.59707496
179Overgrowth (HP:0001548)1.58598835
180Achilles tendon contracture (HP:0001771)1.58456906
181Excessive salivation (HP:0003781)1.58445862
182Drooling (HP:0002307)1.58445862
183Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57798767
184Arachnodactyly (HP:0001166)1.57432000
185Cutaneous melanoma (HP:0012056)1.57006889
186Abnormality of the calcaneus (HP:0008364)1.55938819
187Broad thumb (HP:0011304)1.55595702
188Vertebral compression fractures (HP:0002953)1.54842576
189Fragile skin (HP:0001030)1.54456849
190Joint laxity (HP:0001388)1.54072725
191Short nail (HP:0001799)1.51862475
192Genetic anticipation (HP:0003743)1.51120042
193Mesomelia (HP:0003027)1.50088444
194Abnormality of the Achilles tendon (HP:0005109)1.49594912
195Action tremor (HP:0002345)1.48143060
196Viral hepatitis (HP:0006562)1.47507582
197Abnormality of the nasal septum (HP:0000419)1.46924759
198Abnormal platelet volume (HP:0011876)1.45362917

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.52193709
2MAP3K93.24872946
3TRIM282.90342829
4LATS22.85108576
5PKN22.81238777
6ZAK2.76764347
7BMPR1B2.74718810
8TTN2.71984928
9SCYL22.60178366
10MAP4K22.50929883
11WNK32.49770845
12ACVR1B2.43219209
13NTRK32.36315059
14PDGFRA2.33777562
15NUAK12.27896521
16GRK12.22624455
17MST42.19046226
18TLK12.10596521
19LATS12.09120210
20ADRBK21.96802015
21DDR21.92463998
22MAP3K41.83080721
23CDK121.76906210
24EIF2AK31.76577663
25FRK1.73211818
26CASK1.73155923
27RET1.68839284
28PTK61.68274976
29MKNK21.65389368
30KSR11.64919408
31PAK61.64859314
32KSR21.64343804
33STK391.63929604
34ALK1.62881596
35MAPK131.56995257
36PTK21.56724894
37INSRR1.55166006
38MAP3K101.54931613
39OXSR11.54915903
40BRSK21.54384636
41PAK21.50881297
42RIPK11.50247262
43MAP3K21.48600452
44PINK11.46766219
45PLK31.44215625
46NEK11.43682699
47PAK31.36379822
48STK31.32565886
49BUB11.28548861
50SIK21.28346989
51PDGFRB1.27120430
52NTRK11.24419930
53TNIK1.23391903
54CAMKK11.23336140
55PLK41.22757646
56WEE11.21854270
57MTOR1.17686717
58PRKCH1.17374777
59BCR1.12410145
60MINK11.11431717
61BMX1.09407558
62MUSK1.09263260
63CSNK1G11.07063068
64FER1.06058942
65SGK30.98924757
66EEF2K0.98405080
67MKNK10.98356157
68JAK10.98213832
69PLK20.95932859
70TAF10.95917238
71MELK0.95811903
72TAOK30.95459659
73CSNK1G20.95333946
74TSSK60.94861007
75FGFR30.89879675
76CSNK1G30.89144044
77LRRK20.88113978
78PRKCE0.87671694
79ERBB40.87500419
80MARK10.85766813
81CDK60.83912966
82ADRBK10.83115671
83VRK10.82603590
84PLK10.81963288
85MAP3K130.81508621
86MAP2K70.81052418
87MOS0.81005244
88CSNK1A1L0.79812966
89LIMK10.79357388
90TXK0.79138755
91FGFR10.77857970
92CAMK1G0.77123098
93CAMK1D0.75768398
94STK100.74819188
95WNK40.73388425
96STK38L0.72201933
97TEC0.71920819
98MAP2K40.69894536
99PRKCI0.69782893
100CDC42BPA0.69733107
101TGFBR10.69724161
102MAP2K10.68398723
103TIE10.67568510
104AKT30.66939835
105PHKG20.66757326
106PHKG10.66757326
107PRKCG0.66545324
108ABL20.66308849
109MAP3K120.65901259
110EIF2AK10.65455177
111BRSK10.65264216
112MARK30.64958169
113SGK20.64913979
114ERN10.64662054
115MAP3K80.64408585
116ERBB30.63952479
117TAOK10.63734342
118BCKDK0.62994159
119PDK20.62958099
120PRKD10.61794030
121NEK90.61326322
122FGFR40.61157133
123ATR0.60969510
124EPHA40.60727028
125FGFR20.60501431
126WNK10.59013294
127DAPK20.59013257
128RIPK40.58993954
129MAPK100.58065041
130PNCK0.57916570
131CDC70.57684450
132SGK10.57578134
133INSR0.56726749
134SRPK10.54664794
135HCK0.54280413
136MARK20.54254750
137ATM0.53926480
138MAP3K70.53831168
139MAP3K140.53773706
140JAK30.53743822
141STK110.53361759
142CDK50.53232452
143TRPM70.53128895
144EPHA30.53115303
145NEK20.52986896
146FLT30.52512548
147SIK30.51678095
148CHUK0.51167988
149SIK10.50453777
150PIK3CA0.49632687
151EIF2AK20.49255355
152STK380.47848933
153TESK10.46760885
154CAMKK20.46717898
155FYN0.46548899
156MAPKAPK30.45078351
157EGFR0.43164706
158TYRO30.41800504
159PTK2B0.41789577
160PDPK10.41190191
161PBK0.40976594
162FGR0.40746957
163CCNB10.40265573
164CHEK20.40233617
165DYRK1B0.40174606
166STK160.40015956
167GRK50.39910260
168MAP3K50.39757258
169CSNK1D0.39176422
170PDK10.39055460
171MAPKAPK50.38939944
172ABL10.38825773
173CSNK1A10.38695705
174PKN10.38169819
175CAMK2A0.37786085
176GRK70.35601451
177RPS6KA50.34225855
178TTK0.33849522
179NLK0.31846456

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.94124803
2Protein export_Homo sapiens_hsa030602.91215832
3Phototransduction_Homo sapiens_hsa047442.53570091
4Homologous recombination_Homo sapiens_hsa034402.49170856
5Non-homologous end-joining_Homo sapiens_hsa034502.34677856
6Fanconi anemia pathway_Homo sapiens_hsa034602.34299371
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.32307183
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31692771
9Basal transcription factors_Homo sapiens_hsa030222.22861233
10Selenocompound metabolism_Homo sapiens_hsa004502.19261384
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11319826
12RNA degradation_Homo sapiens_hsa030182.11281947
13Butanoate metabolism_Homo sapiens_hsa006502.04350903
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97422181
15Proteasome_Homo sapiens_hsa030501.90043996
16RNA polymerase_Homo sapiens_hsa030201.86750577
17Propanoate metabolism_Homo sapiens_hsa006401.78748701
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.78734158
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78169356
20Chronic myeloid leukemia_Homo sapiens_hsa052201.74972145
21Glioma_Homo sapiens_hsa052141.73285906
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71906111
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69706452
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69107601
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68807314
26Nicotine addiction_Homo sapiens_hsa050331.68769872
27Sulfur metabolism_Homo sapiens_hsa009201.62159928
28Type II diabetes mellitus_Homo sapiens_hsa049301.61641476
29Oxidative phosphorylation_Homo sapiens_hsa001901.58373353
30One carbon pool by folate_Homo sapiens_hsa006701.50516905
31Focal adhesion_Homo sapiens_hsa045101.49129685
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48251819
33mTOR signaling pathway_Homo sapiens_hsa041501.45511530
34Proteoglycans in cancer_Homo sapiens_hsa052051.43566866
35Pancreatic cancer_Homo sapiens_hsa052121.43185373
36Linoleic acid metabolism_Homo sapiens_hsa005911.40658159
37Tryptophan metabolism_Homo sapiens_hsa003801.40176913
38MicroRNAs in cancer_Homo sapiens_hsa052061.38710617
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33423938
40Dorso-ventral axis formation_Homo sapiens_hsa043201.32534186
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30719674
42Adherens junction_Homo sapiens_hsa045201.28369400
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.28019823
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27831769
45Mismatch repair_Homo sapiens_hsa034301.27410347
46Amoebiasis_Homo sapiens_hsa051461.26628422
47Caffeine metabolism_Homo sapiens_hsa002321.25936857
48Ether lipid metabolism_Homo sapiens_hsa005651.22696762
49Steroid biosynthesis_Homo sapiens_hsa001001.22102623
50Regulation of autophagy_Homo sapiens_hsa041401.20592369
51Endometrial cancer_Homo sapiens_hsa052131.19715366
52Collecting duct acid secretion_Homo sapiens_hsa049661.19230591
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18875843
54Taste transduction_Homo sapiens_hsa047421.18864863
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18250271
56ErbB signaling pathway_Homo sapiens_hsa040121.17723331
57Renal cell carcinoma_Homo sapiens_hsa052111.16937900
58Non-small cell lung cancer_Homo sapiens_hsa052231.16604298
59Shigellosis_Homo sapiens_hsa051311.16391005
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15731275
61Estrogen signaling pathway_Homo sapiens_hsa049151.15624143
62Regulation of actin cytoskeleton_Homo sapiens_hsa048101.11629536
63Parkinsons disease_Homo sapiens_hsa050121.09494726
64Small cell lung cancer_Homo sapiens_hsa052221.09444024
65ECM-receptor interaction_Homo sapiens_hsa045121.08561762
66Synaptic vesicle cycle_Homo sapiens_hsa047211.06674686
67Nucleotide excision repair_Homo sapiens_hsa034201.05836485
68Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03422659
69Long-term potentiation_Homo sapiens_hsa047201.03007757
70Melanoma_Homo sapiens_hsa052181.02485151
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02463855
72Peroxisome_Homo sapiens_hsa041461.00982659
73VEGF signaling pathway_Homo sapiens_hsa043701.00570334
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00490890
75Salmonella infection_Homo sapiens_hsa051321.00267230
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99380320
77Prolactin signaling pathway_Homo sapiens_hsa049170.99028702
78Bladder cancer_Homo sapiens_hsa052190.98943834
79GnRH signaling pathway_Homo sapiens_hsa049120.98255178
80Dilated cardiomyopathy_Homo sapiens_hsa054140.98099378
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97395767
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95283974
83Colorectal cancer_Homo sapiens_hsa052100.94678164
84Fatty acid elongation_Homo sapiens_hsa000620.94427658
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94347878
86Olfactory transduction_Homo sapiens_hsa047400.93383295
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93016168
88Prostate cancer_Homo sapiens_hsa052150.92642319
89Hepatitis B_Homo sapiens_hsa051610.92377576
90Osteoclast differentiation_Homo sapiens_hsa043800.92353452
91RNA transport_Homo sapiens_hsa030130.91879311
92Cholinergic synapse_Homo sapiens_hsa047250.91613400
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.91176087
94MAPK signaling pathway_Homo sapiens_hsa040100.90663425
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90608952
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89769531
97Platelet activation_Homo sapiens_hsa046110.89707444
98Axon guidance_Homo sapiens_hsa043600.89378076
99TNF signaling pathway_Homo sapiens_hsa046680.88864260
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88485647
101Insulin signaling pathway_Homo sapiens_hsa049100.88335145
102FoxO signaling pathway_Homo sapiens_hsa040680.87574730
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87125784
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.86547883
105Oxytocin signaling pathway_Homo sapiens_hsa049210.86252417
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86112979
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.85899705
108Toxoplasmosis_Homo sapiens_hsa051450.85885142
109Purine metabolism_Homo sapiens_hsa002300.85326884
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84966500
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84622612
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84253831
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84222029
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84044104
115Dopaminergic synapse_Homo sapiens_hsa047280.83951056
116Endocytosis_Homo sapiens_hsa041440.83712985
117Chemokine signaling pathway_Homo sapiens_hsa040620.83640779
118Choline metabolism in cancer_Homo sapiens_hsa052310.83198646
119B cell receptor signaling pathway_Homo sapiens_hsa046620.82760561
120Hippo signaling pathway_Homo sapiens_hsa043900.82265409
121Rap1 signaling pathway_Homo sapiens_hsa040150.81888308
122Viral myocarditis_Homo sapiens_hsa054160.81811364
123Long-term depression_Homo sapiens_hsa047300.81645208
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81383922
125Gap junction_Homo sapiens_hsa045400.80703132
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.79520679
127Chemical carcinogenesis_Homo sapiens_hsa052040.79242329
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79234191
129Insulin secretion_Homo sapiens_hsa049110.78371890
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78211162
131Insulin resistance_Homo sapiens_hsa049310.76915819
132T cell receptor signaling pathway_Homo sapiens_hsa046600.76858265
133Morphine addiction_Homo sapiens_hsa050320.76802189
134Pyrimidine metabolism_Homo sapiens_hsa002400.75074421
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74981065
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74479903
137Retinol metabolism_Homo sapiens_hsa008300.73684661
138Glutamatergic synapse_Homo sapiens_hsa047240.73489318
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73449525
140Tuberculosis_Homo sapiens_hsa051520.73345054
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72462474
142Alzheimers disease_Homo sapiens_hsa050100.72033587
143Huntingtons disease_Homo sapiens_hsa050160.71473394
144TGF-beta signaling pathway_Homo sapiens_hsa043500.71273683
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70629978
146Leishmaniasis_Homo sapiens_hsa051400.70012612
147Phagosome_Homo sapiens_hsa041450.69897160
148Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69708798
149Viral carcinogenesis_Homo sapiens_hsa052030.68952718
150Circadian rhythm_Homo sapiens_hsa047100.68788329
151Oocyte meiosis_Homo sapiens_hsa041140.68388478
152Serotonergic synapse_Homo sapiens_hsa047260.67390787
153Circadian entrainment_Homo sapiens_hsa047130.66943589
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66536992
155Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65335055
156Leukocyte transendothelial migration_Homo sapiens_hsa046700.64752663
157Apoptosis_Homo sapiens_hsa042100.64448554
158Nitrogen metabolism_Homo sapiens_hsa009100.64358623
159GABAergic synapse_Homo sapiens_hsa047270.63828774
160Cysteine and methionine metabolism_Homo sapiens_hsa002700.63367908
161Malaria_Homo sapiens_hsa051440.62583285
162Ras signaling pathway_Homo sapiens_hsa040140.62177902
163ABC transporters_Homo sapiens_hsa020100.61732796
164beta-Alanine metabolism_Homo sapiens_hsa004100.61050072
165Sphingolipid signaling pathway_Homo sapiens_hsa040710.61036546
166Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60772712
167Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60060142
168Metabolic pathways_Homo sapiens_hsa011000.59900929
169Inositol phosphate metabolism_Homo sapiens_hsa005620.59853411
170Type I diabetes mellitus_Homo sapiens_hsa049400.59837334
171DNA replication_Homo sapiens_hsa030300.59614725
172Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59342337
173Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59323952
174Base excision repair_Homo sapiens_hsa034100.59094073
175p53 signaling pathway_Homo sapiens_hsa041150.58771260
176Glycerolipid metabolism_Homo sapiens_hsa005610.56667003
177SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55949015
178Calcium signaling pathway_Homo sapiens_hsa040200.52924128
179Vitamin B6 metabolism_Homo sapiens_hsa007500.52683091
180Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50857333
181Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48160226
182Cell cycle_Homo sapiens_hsa041100.44091153
183Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41962968
184Salivary secretion_Homo sapiens_hsa049700.41618096
185Fat digestion and absorption_Homo sapiens_hsa049750.37509857
186Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35256667
187Ovarian steroidogenesis_Homo sapiens_hsa049130.33822257
188Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32672546
189Sphingolipid metabolism_Homo sapiens_hsa006000.30765139
190Fatty acid metabolism_Homo sapiens_hsa012120.28753806
191Amphetamine addiction_Homo sapiens_hsa050310.28536441
192Systemic lupus erythematosus_Homo sapiens_hsa053220.26906568
193Cardiac muscle contraction_Homo sapiens_hsa042600.25374486

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