SENP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]). SENPs also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.86292317
2nuclear pore complex assembly (GO:0051292)5.40851351
3regulation of RNA export from nucleus (GO:0046831)4.69628311
4nuclear pore organization (GO:0006999)4.62173249
5cytoplasmic mRNA processing body assembly (GO:0033962)4.52703141
6nucleus localization (GO:0051647)4.20320093
7regulation of sarcomere organization (GO:0060297)4.12415426
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.09069141
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.02663996
10monoubiquitinated protein deubiquitination (GO:0035520)3.95239720
11pore complex assembly (GO:0046931)3.87725181
12regulation of nucleobase-containing compound transport (GO:0032239)3.77375160
13pre-miRNA processing (GO:0031054)3.57209040
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.44649602
15neural tube formation (GO:0001841)3.38346923
16negative regulation of histone methylation (GO:0031061)3.37872743
17regulation of DNA endoreduplication (GO:0032875)3.36645288
18regulation of sister chromatid cohesion (GO:0007063)3.29314867
19negative regulation of DNA repair (GO:0045738)3.26237345
20corticosteroid receptor signaling pathway (GO:0031958)3.19527244
21glucocorticoid receptor signaling pathway (GO:0042921)3.19049921
22regulation of clathrin-mediated endocytosis (GO:2000369)3.15444514
23sister chromatid cohesion (GO:0007062)3.12080366
24positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.11456127
25regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.11456127
26negative regulation of fibroblast apoptotic process (GO:2000270)3.04680859
27positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.04469255
28positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.04469255
29positive regulation of mitotic sister chromatid separation (GO:1901970)3.04469255
30mRNA stabilization (GO:0048255)3.02877610
31RNA stabilization (GO:0043489)3.02877610
32regulation of histone H3-K9 methylation (GO:0051570)3.01299994
33histone H2A monoubiquitination (GO:0035518)2.99490603
34positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.99206741
35regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.99206741
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96856299
37peptidyl-lysine trimethylation (GO:0018023)2.95506520
38definitive hemopoiesis (GO:0060216)2.95078172
39establishment of protein localization to Golgi (GO:0072600)2.93733649
40regulation of pigment cell differentiation (GO:0050932)2.93581316
41synapsis (GO:0007129)2.92651785
42DNA topological change (GO:0006265)2.92545031
43histone-serine phosphorylation (GO:0035404)2.92492507
44dorsal/ventral axis specification (GO:0009950)2.92130111
45regulation of establishment of cell polarity (GO:2000114)2.90868118
46negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89204138
47histone H3-K36 demethylation (GO:0070544)2.89114522
48negative regulation of potassium ion transmembrane transport (GO:1901380)2.89094015
49histone H3-K9 methylation (GO:0051567)2.88766273
50replicative senescence (GO:0090399)2.86210100
51protein K48-linked deubiquitination (GO:0071108)2.85354011
52negative regulation of muscle hypertrophy (GO:0014741)2.85203705
53insulin-like growth factor receptor signaling pathway (GO:0048009)2.83285168
54otic vesicle formation (GO:0030916)2.83023430
55type B pancreatic cell development (GO:0003323)2.80920485
56regulation of mRNA stability (GO:0043488)2.80601113
57histone H3-K4 trimethylation (GO:0080182)2.80140063
58positive regulation by host of viral transcription (GO:0043923)2.79514164
59genitalia morphogenesis (GO:0035112)2.78525218
60embryonic camera-type eye morphogenesis (GO:0048596)2.76593131
61histone lysine demethylation (GO:0070076)2.75788770
62mitotic chromosome condensation (GO:0007076)2.75547652
63artery development (GO:0060840)2.74741140
64plasma membrane repair (GO:0001778)2.69404367
65histone H3-K9 demethylation (GO:0033169)2.69056876
66NLS-bearing protein import into nucleus (GO:0006607)2.68983132
67acrosome assembly (GO:0001675)2.68408232
68regulation of transforming growth factor beta2 production (GO:0032909)2.68113104
69hippo signaling (GO:0035329)2.67914396
70negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.67882926
71protein targeting to Golgi (GO:0000042)2.67853118
72retina layer formation (GO:0010842)2.66813218
73embryonic foregut morphogenesis (GO:0048617)2.66426069
74positive regulation of mRNA catabolic process (GO:0061014)2.66297938
75dosage compensation (GO:0007549)2.66162349
76reciprocal meiotic recombination (GO:0007131)2.65764176
77reciprocal DNA recombination (GO:0035825)2.65764176
78regulation of RNA stability (GO:0043487)2.65033610
79striated muscle atrophy (GO:0014891)2.63301478
80histone demethylation (GO:0016577)2.62226552
81microtubule anchoring (GO:0034453)2.61670624
82peptidyl-threonine dephosphorylation (GO:0035970)2.61606262
83chromatin assembly (GO:0031497)2.60518805
84regulation of histone methylation (GO:0031060)2.60359991
85response to pheromone (GO:0019236)2.59116207
86neuronal stem cell maintenance (GO:0097150)2.58005387
87regulation of non-canonical Wnt signaling pathway (GO:2000050)2.57863591
88ncRNA catabolic process (GO:0034661)2.57756991
89metaphase plate congression (GO:0051310)2.57121590
90negative regulation of oligodendrocyte differentiation (GO:0048715)2.56704551
91alternative mRNA splicing, via spliceosome (GO:0000380)2.56433338
92negative regulation of cardiac muscle hypertrophy (GO:0010614)2.56153149
93histone H3-K9 modification (GO:0061647)2.54343428
94regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.53531863
95histone H3-K4 methylation (GO:0051568)2.53055377
96regulation of action potential (GO:0098900)2.51758304
97gene silencing by RNA (GO:0031047)2.51375179
98positive regulation of chromosome segregation (GO:0051984)2.51245883
99mesodermal cell differentiation (GO:0048333)2.50823175
100negative regulation of histone modification (GO:0031057)2.50404250
101regulation of mRNA catabolic process (GO:0061013)2.49697431
102retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49555935
103lipid translocation (GO:0034204)2.47768344
104phospholipid translocation (GO:0045332)2.47768344
105nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.47628030
106regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.47532112
107regulation of stem cell maintenance (GO:2000036)2.47304932
108pancreas development (GO:0031016)2.46361463
109DNA unwinding involved in DNA replication (GO:0006268)2.46353847
110positive regulation of histone H3-K4 methylation (GO:0051571)2.46077585
111positive regulation of mRNA 3-end processing (GO:0031442)2.45978514
112regulation of heart morphogenesis (GO:2000826)2.45846306
113regulation of histone H3-K4 methylation (GO:0051569)2.45073821
114positive regulation of microtubule polymerization (GO:0031116)2.44989718
115mitotic nuclear envelope disassembly (GO:0007077)2.44667721
116forebrain morphogenesis (GO:0048853)2.44548936
117kidney morphogenesis (GO:0060993)2.43986685
118regulation of mitotic spindle organization (GO:0060236)2.43020055
119rRNA catabolic process (GO:0016075)2.42993104
120regulation of mRNA 3-end processing (GO:0031440)2.41220729
121mRNA splice site selection (GO:0006376)2.40760354
122gastrulation with mouth forming second (GO:0001702)2.40622793
123positive regulation of DNA-templated transcription, initiation (GO:2000144)2.40285057
124pericardium development (GO:0060039)2.39970279
125histone mRNA catabolic process (GO:0071044)2.39888755
126protein K11-linked deubiquitination (GO:0035871)2.39422903
127negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38700693
128negative regulation of translation, ncRNA-mediated (GO:0040033)2.38700693
129regulation of translation, ncRNA-mediated (GO:0045974)2.38700693
130nuclear envelope disassembly (GO:0051081)2.38591511
131membrane disassembly (GO:0030397)2.38591511
132meiotic chromosome segregation (GO:0045132)2.38365206
133regulation of SMAD protein import into nucleus (GO:0060390)2.37715820
134regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.37188230
135peptidyl-lysine dimethylation (GO:0018027)2.36760620
136kinetochore organization (GO:0051383)2.36125984
137sister chromatid segregation (GO:0000819)2.35516400
138mitotic metaphase plate congression (GO:0007080)2.35308788
139ribonucleoprotein complex disassembly (GO:0032988)2.34391188
140regulation of hippo signaling (GO:0035330)2.33873034
141regulation of establishment or maintenance of cell polarity (GO:0032878)2.33468563
142regulation of fibroblast apoptotic process (GO:2000269)2.33135606
143peptidyl-lysine methylation (GO:0018022)2.33042666
144negative regulation of neurotransmitter secretion (GO:0046929)2.32909874
145negative regulation of neurotransmitter transport (GO:0051589)2.32806409
146glandular epithelial cell development (GO:0002068)2.32558989
147regulation of response to tumor cell (GO:0002834)2.32399119
148positive regulation of response to tumor cell (GO:0002836)2.32399119
149positive regulation of immune response to tumor cell (GO:0002839)2.32399119
150regulation of immune response to tumor cell (GO:0002837)2.32399119
151negative regulation of DNA-dependent DNA replication (GO:2000104)2.31859392
152somite development (GO:0061053)2.31717839
153histone monoubiquitination (GO:0010390)2.31380991
154positive regulation of developmental pigmentation (GO:0048087)2.31319889
155cellular response to ethanol (GO:0071361)2.31203928
156cilium or flagellum-dependent cell motility (GO:0001539)2.30026900
157interkinetic nuclear migration (GO:0022027)2.29854061
158radial glial cell differentiation (GO:0060019)2.29773678
159DNA duplex unwinding (GO:0032508)2.29471628
160epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.29367523
161paraxial mesoderm development (GO:0048339)2.29007124
162piRNA metabolic process (GO:0034587)2.28381251
163centriole replication (GO:0007099)2.28071287
164prenylation (GO:0097354)2.27545246
165protein prenylation (GO:0018342)2.27545246
166epithelial cell differentiation involved in kidney development (GO:0035850)2.27348707
167histone lysine methylation (GO:0034968)2.27046211
168positive regulation of histone deacetylation (GO:0031065)2.26981768
169nerve growth factor signaling pathway (GO:0038180)2.26333733
170organelle disassembly (GO:1903008)2.26134137
171positive regulation of SMAD protein import into nucleus (GO:0060391)2.26081655
172negative regulation of chromatin modification (GO:1903309)2.25983334
173lymphoid progenitor cell differentiation (GO:0002320)2.25264084
174smooth muscle tissue development (GO:0048745)2.24094776
175positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.23383407
176negative regulation of protein localization to cell surface (GO:2000009)2.22649747

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.27467608
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.48363076
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.21961759
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.76167051
5GATA1_22025678_ChIP-Seq_K562_Human3.48813428
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.45679224
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33740830
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.33671889
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.23256144
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.10259050
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.06206995
12TP63_19390658_ChIP-ChIP_HaCaT_Human3.03658187
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68942054
14GBX2_23144817_ChIP-Seq_PC3_Human2.68377801
15VDR_22108803_ChIP-Seq_LS180_Human2.66991741
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58276486
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43914443
18ZNF274_21170338_ChIP-Seq_K562_Hela2.22585417
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20907827
20HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.18134860
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.16418970
22* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.15743450
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08296187
24TAF15_26573619_Chip-Seq_HEK293_Human2.02734303
25P300_19829295_ChIP-Seq_ESCs_Human1.92173227
26FUS_26573619_Chip-Seq_HEK293_Human1.87311946
27* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.84742995
28EWS_26573619_Chip-Seq_HEK293_Human1.84437461
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.84155505
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.81641158
31TP53_16413492_ChIP-PET_HCT116_Human1.77074725
32SMAD4_21799915_ChIP-Seq_A2780_Human1.75150610
33ER_23166858_ChIP-Seq_MCF-7_Human1.75094539
34AR_21909140_ChIP-Seq_LNCAP_Human1.72783023
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72589680
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70103981
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68383880
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68096486
39* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68084482
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.66643355
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61638751
42PKCTHETA_26484144_Chip-Seq_BREAST_Human1.61486841
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.60010144
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.58515838
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58093828
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57451222
47MYC_22102868_ChIP-Seq_BL_Human1.55789727
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55017345
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53117615
50* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51521073
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50058797
52TCF4_23295773_ChIP-Seq_U87_Human1.50009554
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49612239
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.49373971
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.48834436
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46715021
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46304906
58* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.44276003
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43561457
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43512707
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43194045
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42856822
63BRD4_25478319_ChIP-Seq_HGPS_Human1.42703986
64ISL1_27105846_Chip-Seq_CPCs_Mouse1.41480533
65BCAT_22108803_ChIP-Seq_LS180_Human1.39696772
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39112378
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.38247653
68AR_21572438_ChIP-Seq_LNCaP_Human1.35666436
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35503223
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34622422
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.33750050
72RNF2_27304074_Chip-Seq_NSC_Mouse1.33157024
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.32490278
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31702108
75AR_25329375_ChIP-Seq_VCAP_Human1.31250996
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.28944771
77* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28587520
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28319375
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.27093381
80RUNX2_22187159_ChIP-Seq_PCA_Human1.26328967
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26209982
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25329113
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25206223
84* CHD1_26751641_Chip-Seq_LNCaP_Human1.24913188
85P53_22387025_ChIP-Seq_ESCs_Mouse1.24739147
86* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24651114
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24105681
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24060719
89EZH2_22144423_ChIP-Seq_EOC_Human1.23731297
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21299286
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21299286
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21141282
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19072950
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18590949
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18115872
96TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17333066
97SCL_19346495_ChIP-Seq_HPC-7_Human1.17193814
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17087474
99CBP_20019798_ChIP-Seq_JUKART_Human1.17087474
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.15897632
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14480365
102POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14262803
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13408050
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11962059
105* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11759343
106* TCF7_22412390_ChIP-Seq_EML_Mouse1.11705422
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.11586427
108* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11172484
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11039770
110TCF4_22108803_ChIP-Seq_LS180_Human1.09373030
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.09036925
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09020026
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.06946266
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.05907013
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.05210807
116NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05188568
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04914047
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04280767
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.03369686
120P300_18555785_Chip-Seq_ESCs_Mouse1.03250415
121RUNX_20019798_ChIP-Seq_JUKART_Human1.02453182
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01628908
123KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01628908
124KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01628908
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01559190
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01477626
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01359413
128ELK1_19687146_ChIP-ChIP_HELA_Human1.01108429
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00777616
130CLOCK_20551151_ChIP-Seq_293T_Human1.00493128
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00358114
132MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00320688
133PIAS1_25552417_ChIP-Seq_VCAP_Human0.99827000
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.99241256
135* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97112548
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97016929
137YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96893515
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96625218
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96417484
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95881259
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95655276
142* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95532482
143ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93760350
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.93211058
145FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93128240
146SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92162111
147EP300_21415370_ChIP-Seq_HL-1_Mouse0.91449816
148STAT3_23295773_ChIP-Seq_U87_Human0.90793322
149PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89804526
150KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87411828
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.87228595
152POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86344770
153SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85128333
154SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85128333
155NOTCH1_21737748_ChIP-Seq_TLL_Human0.84475010
156MYB_26560356_Chip-Seq_TH1_Human0.83486781
157IGF1R_20145208_ChIP-Seq_DFB_Human0.82995409
158ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82961235
159UBF1/2_26484160_Chip-Seq_HMECs_Human0.81955821
160PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81757637
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81361774
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81361774
163AHR_22903824_ChIP-Seq_MCF-7_Human0.80975419
164KDM2B_26808549_Chip-Seq_JURKAT_Human0.80740733
165* CJUN_26792858_Chip-Seq_BT549_Human0.80113502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting2.94110016
2MP0008057_abnormal_DNA_replication2.92635292
3MP0002102_abnormal_ear_morphology2.74821397
4MP0002009_preneoplasia2.58406598
5MP0003121_genomic_imprinting2.53085351
6MP0003195_calcinosis2.44692556
7MP0000537_abnormal_urethra_morphology2.40677081
8MP0004145_abnormal_muscle_electrophysio2.10684821
9MP0005248_abnormal_Harderian_gland2.10218258
10MP0006292_abnormal_olfactory_placode2.08330323
11MP0010352_gastrointestinal_tract_polyps2.00371743
12MP0008877_abnormal_DNA_methylation1.99673108
13MP0002877_abnormal_melanocyte_morpholog1.99052824
14MP0004084_abnormal_cardiac_muscle1.95743500
15MP0002160_abnormal_reproductive_system1.93530770
16MP0002928_abnormal_bile_duct1.93007915
17MP0003937_abnormal_limbs/digits/tail_de1.90460141
18MP0003123_paternal_imprinting1.89166103
19MP0003252_abnormal_bile_duct1.87333022
20MP0005174_abnormal_tail_pigmentation1.86713241
21MP0003890_abnormal_embryonic-extraembry1.83730008
22MP0004133_heterotaxia1.75631384
23MP0005076_abnormal_cell_differentiation1.73705383
24MP0004808_abnormal_hematopoietic_stem1.71965532
25MP0003935_abnormal_craniofacial_develop1.70896213
26MP0000428_abnormal_craniofacial_morphol1.68978596
27MP0002084_abnormal_developmental_patter1.68910925
28MP0010094_abnormal_chromosome_stability1.68775925
29MP0009250_abnormal_appendicular_skeleto1.66016941
30MP0003122_maternal_imprinting1.64884053
31MP0009053_abnormal_anal_canal1.61241812
32MP0001293_anophthalmia1.60384024
33MP0009703_decreased_birth_body1.59841610
34MP0003567_abnormal_fetal_cardiomyocyte1.59229928
35MP0003385_abnormal_body_wall1.58633556
36MP0010678_abnormal_skin_adnexa1.56385880
37MP0003950_abnormal_plasma_membrane1.55079636
38MP0003077_abnormal_cell_cycle1.54408662
39MP0004197_abnormal_fetal_growth/weight/1.52444098
40MP0000631_abnormal_neuroendocrine_gland1.50089871
41MP0005220_abnormal_exocrine_pancreas1.48867456
42MP0004957_abnormal_blastocyst_morpholog1.48180097
43MP0002396_abnormal_hematopoietic_system1.46742930
44MP0000383_abnormal_hair_follicle1.46559570
45MP0002086_abnormal_extraembryonic_tissu1.46155317
46MP0006054_spinal_hemorrhage1.46152245
47MP0003755_abnormal_palate_morphology1.42854372
48MP0004036_abnormal_muscle_relaxation1.42667689
49MP0010234_abnormal_vibrissa_follicle1.41741919
50MP0002085_abnormal_embryonic_tissue1.41588574
51MP0005084_abnormal_gallbladder_morpholo1.39820474
52MP0003283_abnormal_digestive_organ1.39611744
53MP0001879_abnormal_lymphatic_vessel1.39462510
54MP0005380_embryogenesis_phenotype1.38226848
55MP0001672_abnormal_embryogenesis/_devel1.38226848
56MP0000733_abnormal_muscle_development1.38176076
57MP0000516_abnormal_urinary_system1.37112121
58MP0005367_renal/urinary_system_phenotyp1.37112121
59MP0002938_white_spotting1.36953370
60MP0005187_abnormal_penis_morphology1.36359266
61MP0001485_abnormal_pinna_reflex1.36227988
62MP0003300_gastrointestinal_ulcer1.36198556
63MP0000432_abnormal_head_morphology1.36190658
64MP0004264_abnormal_extraembryonic_tissu1.34648398
65MP0002088_abnormal_embryonic_growth/wei1.34540373
66MP0005389_reproductive_system_phenotype1.34094193
67MP0008007_abnormal_cellular_replicative1.33386229
68MP0003984_embryonic_growth_retardation1.33227964
69MP0002166_altered_tumor_susceptibility1.32789051
70MP0000778_abnormal_nervous_system1.30674580
71MP0002095_abnormal_skin_pigmentation1.29325890
72MP0008995_early_reproductive_senescence1.28727911
73MP0002233_abnormal_nose_morphology1.28395129
74MP0010030_abnormal_orbit_morphology1.26887505
75MP0001730_embryonic_growth_arrest1.26706888
76MP0001697_abnormal_embryo_size1.25661869
77MP0003119_abnormal_digestive_system1.25033356
78MP0010368_abnormal_lymphatic_system1.24704977
79MP0009672_abnormal_birth_weight1.23883226
80MP0002925_abnormal_cardiovascular_devel1.22385791
81MP0000566_synostosis1.21779738
82MP0003693_abnormal_embryo_hatching1.21632191
83MP0004215_abnormal_myocardial_fiber1.20138832
84MP0001346_abnormal_lacrimal_gland1.18960493
85MP0003942_abnormal_urinary_system1.18938879
86MP0002697_abnormal_eye_size1.18742203
87MP0001286_abnormal_eye_development1.17438598
88MP0000350_abnormal_cell_proliferation1.17426000
89MP0002116_abnormal_craniofacial_bone1.16819331
90MP0004885_abnormal_endolymph1.16786129
91MP0002092_abnormal_eye_morphology1.15812357
92MP0003115_abnormal_respiratory_system1.15765126
93MP0003941_abnormal_skin_development1.11599877
94MP0003705_abnormal_hypodermis_morpholog1.10958384
95MP0003111_abnormal_nucleus_morphology1.07200630
96MP0004185_abnormal_adipocyte_glucose1.05391657
97MP0009384_cardiac_valve_regurgitation1.03907976
98MP0001915_intracranial_hemorrhage1.03244827
99MP0001299_abnormal_eye_distance/1.02445675
100MP0000569_abnormal_digit_pigmentation1.01990586
101MP0000534_abnormal_ureter_morphology1.01760176
102MP0003763_abnormal_thymus_physiology1.01208945
103MP0004130_abnormal_muscle_cell1.01111537
104MP0001486_abnormal_startle_reflex1.01067311
105MP0002109_abnormal_limb_morphology1.00700843
106MP0008775_abnormal_heart_ventricle1.00426425
107MP0004272_abnormal_basement_membrane0.99635971
108MP0002932_abnormal_joint_morphology0.99290561
109MP0004134_abnormal_chest_morphology0.99042848
110MP0003136_yellow_coat_color0.97658294
111MP0001340_abnormal_eyelid_morphology0.97478019
112MP0002177_abnormal_outer_ear0.97016924
113MP0000462_abnormal_digestive_system0.96258869
114MP0005623_abnormal_meninges_morphology0.95559851
115MP0002006_tumorigenesis0.95371262
116MP0002234_abnormal_pharynx_morphology0.94971130
117MP0004484_altered_response_of0.94332517
118MP0003828_pulmonary_edema0.94156890
119MP0002114_abnormal_axial_skeleton0.94134093
120MP0003656_abnormal_erythrocyte_physiolo0.93531220
121MP0000762_abnormal_tongue_morphology0.91818546
122MP0010307_abnormal_tumor_latency0.90715560
123MP0001784_abnormal_fluid_regulation0.89063735
124MP0008058_abnormal_DNA_repair0.88072404
125MP0003646_muscle_fatigue0.88059546
126MP0001188_hyperpigmentation0.87094538
127MP0002111_abnormal_tail_morphology0.85177929
128MP0006072_abnormal_retinal_apoptosis0.85174996
129MP0003943_abnormal_hepatobiliary_system0.85033331
130MP0002080_prenatal_lethality0.84528949
131MP0002282_abnormal_trachea_morphology0.84243571
132MP0000427_abnormal_hair_cycle0.83835014
133MP0004043_abnormal_pH_regulation0.83483649
134MP0005391_vision/eye_phenotype0.83160684
135MP0005551_abnormal_eye_electrophysiolog0.82802386
136MP0002249_abnormal_larynx_morphology0.82587544
137MP0003315_abnormal_perineum_morphology0.79659825
138MP0001177_atelectasis0.79190068
139MP0002751_abnormal_autonomic_nervous0.78774972
140MP0004147_increased_porphyrin_level0.77446016
141MP0005253_abnormal_eye_physiology0.77270013
142MP0001145_abnormal_male_reproductive0.74493410
143MP0001929_abnormal_gametogenesis0.72648889
144MP0004142_abnormal_muscle_tone0.72149942
145MP0002067_abnormal_sensory_capabilities0.70874197
146MP0003861_abnormal_nervous_system0.70543221
147MP0000470_abnormal_stomach_morphology0.70384788
148MP0005195_abnormal_posterior_eye0.68940650
149MP0001324_abnormal_eye_pigmentation0.68632129
150MP0003221_abnormal_cardiomyocyte_apopto0.67874462
151MP0008961_abnormal_basal_metabolism0.67721161
152MP0004742_abnormal_vestibular_system0.67612611
153MP0005386_behavior/neurological_phenoty0.67583337
154MP0004924_abnormal_behavior0.67583337
155MP0003698_abnormal_male_reproductive0.67444767
156MP0002210_abnormal_sex_determination0.67358363
157MP0001270_distended_abdomen0.67078972
158MP0005075_abnormal_melanosome_morpholog0.66023455

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.57463633
2Genetic anticipation (HP:0003743)4.46916616
3Muscle hypertrophy of the lower extremities (HP:0008968)4.26044287
4Abnormality of the fingertips (HP:0001211)3.79038379
5Papillary thyroid carcinoma (HP:0002895)3.36988988
6Progressive cerebellar ataxia (HP:0002073)3.33218816
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.33192381
8Short 4th metacarpal (HP:0010044)3.33192381
9Abnormality of the left ventricular outflow tract (HP:0011103)3.32297840
10Subaortic stenosis (HP:0001682)3.32297840
11Gaze-evoked nystagmus (HP:0000640)3.23028837
12Protruding tongue (HP:0010808)3.16599227
13Renal cortical cysts (HP:0000803)3.13182339
14Calf muscle hypertrophy (HP:0008981)3.11377346
15Abnormality of the renal cortex (HP:0011035)2.99283459
16Dysmetric saccades (HP:0000641)2.96677651
17Subacute progressive viral hepatitis (HP:0006572)2.95286428
18Acute myeloid leukemia (HP:0004808)2.86203489
19Long eyelashes (HP:0000527)2.83972582
20Lip pit (HP:0100267)2.83959415
21Fair hair (HP:0002286)2.74112581
22Abnormality of the nasal septum (HP:0000419)2.68106698
23Midline defect of the nose (HP:0004122)2.64502382
24Hip dysplasia (HP:0001385)2.59550457
25Generalized hypopigmentation of hair (HP:0011358)2.55731619
26Hypoplastic labia majora (HP:0000059)2.52306191
27Narrow palate (HP:0000189)2.49953511
28Abnormality of the renal medulla (HP:0100957)2.49420313
29Metaphyseal dysplasia (HP:0100255)2.48844345
30Hypoplastic ischia (HP:0003175)2.48388746
31Tubulointerstitial nephritis (HP:0001970)2.47585535
32Macroorchidism (HP:0000053)2.45801346
33Facial hemangioma (HP:0000329)2.42260950
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.42057285
35Hypoplastic iliac wings (HP:0002866)2.37728897
36Pancreatic fibrosis (HP:0100732)2.37295361
37Colon cancer (HP:0003003)2.35975962
38Rectal prolapse (HP:0002035)2.32036469
39Abnormality of the 4th metacarpal (HP:0010012)2.31043518
40Hyperventilation (HP:0002883)2.30486734
41Asymmetry of the thorax (HP:0001555)2.30204089
42Pancreatic cysts (HP:0001737)2.29561631
43Abnormality of the labia majora (HP:0012881)2.27852706
44Abnormal biliary tract morphology (HP:0012440)2.27150227
45Deviation of the thumb (HP:0009603)2.26996130
46Abnormality of the parietal bone (HP:0002696)2.23674051
47Proximal placement of thumb (HP:0009623)2.23430298
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.20083047
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20083047
50Broad thumb (HP:0011304)2.19725192
51Deep philtrum (HP:0002002)2.19478838
52Abnormality of the ischium (HP:0003174)2.19316654
53Shallow orbits (HP:0000586)2.18529499
54Neoplasm of the tracheobronchial system (HP:0100552)2.14547889
55Nephronophthisis (HP:0000090)2.13970672
56Urinary bladder sphincter dysfunction (HP:0002839)2.12144094
57Myotonia (HP:0002486)2.10305201
58Gastrointestinal carcinoma (HP:0002672)2.09988396
59Malignant gastrointestinal tract tumors (HP:0006749)2.09988396
60Chronic hepatic failure (HP:0100626)2.08649098
61Abnormality of midbrain morphology (HP:0002418)2.08498202
62Molar tooth sign on MRI (HP:0002419)2.08498202
63Constricted visual fields (HP:0001133)2.05990943
64Truncal obesity (HP:0001956)2.05888567
65Thick eyebrow (HP:0000574)2.05858881
66True hermaphroditism (HP:0010459)2.05318100
67Low anterior hairline (HP:0000294)2.05074379
68Stomach cancer (HP:0012126)2.02590974
69Thyroid carcinoma (HP:0002890)2.02275718
70Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01914290
71Medulloblastoma (HP:0002885)2.01337225
72Absent frontal sinuses (HP:0002688)2.00125184
73Broad-based gait (HP:0002136)1.99887742
74Spinal cord lesions (HP:0100561)1.99597998
75Syringomyelia (HP:0003396)1.99597998
76Neoplasm of the oral cavity (HP:0100649)1.99267834
77Hematochezia (HP:0002573)1.98371586
78Supernumerary ribs (HP:0005815)1.97473854
79Thyroiditis (HP:0100646)1.97304195
80Increased nuchal translucency (HP:0010880)1.97203402
81Transitional cell carcinoma of the bladder (HP:0006740)1.94670779
82Scanning speech (HP:0002168)1.94590659
83Widely spaced teeth (HP:0000687)1.92347505
84Broad palm (HP:0001169)1.92049961
85Trigonocephaly (HP:0000243)1.91853161
86Biliary tract neoplasm (HP:0100574)1.90999368
87Chorioretinal atrophy (HP:0000533)1.89601434
88Exostoses (HP:0100777)1.88700653
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.86355929
90Gonadotropin excess (HP:0000837)1.83565988
91Attenuation of retinal blood vessels (HP:0007843)1.83347627
92Febrile seizures (HP:0002373)1.82291557
93Short tibia (HP:0005736)1.81391077
94Broad phalanges of the hand (HP:0009768)1.81352984
95Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79545742
96Glioma (HP:0009733)1.77978195
97Increased number of teeth (HP:0011069)1.77967259
98Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77503647
99Pelvic girdle muscle weakness (HP:0003749)1.77144841
100Drooling (HP:0002307)1.77002956
101Alveolar cell carcinoma (HP:0006519)1.76552767
102Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76455266
103Acute lymphatic leukemia (HP:0006721)1.76295596
104Abnormality of the corticospinal tract (HP:0002492)1.75527159
105Short chin (HP:0000331)1.75212548
106Clitoromegaly (HP:0000057)1.74622678
107Bladder carcinoma (HP:0002862)1.73985707
108Bladder neoplasm (HP:0009725)1.73985707
109Germ cell neoplasia (HP:0100728)1.72899451
110Microglossia (HP:0000171)1.72797232
111Abnormality of chromosome stability (HP:0003220)1.72653885
112Cutis marmorata (HP:0000965)1.72572205
113Genital tract atresia (HP:0001827)1.71962958
114Preaxial foot polydactyly (HP:0001841)1.71825937
115Impaired smooth pursuit (HP:0007772)1.71230767
116Cubitus valgus (HP:0002967)1.71180226
117Broad phalanx (HP:0006009)1.70810475
118Hypoplasia of the thymus (HP:0000778)1.70148564
119Absent/shortened dynein arms (HP:0200106)1.69862778
120Dynein arm defect of respiratory motile cilia (HP:0012255)1.69862778
121Supernumerary bones of the axial skeleton (HP:0009144)1.69184736
122Limited elbow extension (HP:0001377)1.69046398
123Aqueductal stenosis (HP:0002410)1.68987276
124Broad finger (HP:0001500)1.68247175
125Heterotopia (HP:0002282)1.68106449
126Abnormality of the axillary hair (HP:0100134)1.67849376
127Abnormality of secondary sexual hair (HP:0009888)1.67849376
128Clumsiness (HP:0002312)1.67051880
129Synophrys (HP:0000664)1.66025890
130Hepatoblastoma (HP:0002884)1.65891928
131Hypoplasia of the maxilla (HP:0000327)1.65812015
132Aortic aneurysm (HP:0004942)1.65387515
133Dysdiadochokinesis (HP:0002075)1.65067783
134Sparse lateral eyebrow (HP:0005338)1.64581114
135Shawl scrotum (HP:0000049)1.64252820
136Poor coordination (HP:0002370)1.63812482
137Sandal gap (HP:0001852)1.63666824
138Leiomyosarcoma (HP:0100243)1.63542550
139Uterine leiomyosarcoma (HP:0002891)1.63542550
140Abnormality of ocular smooth pursuit (HP:0000617)1.63509484
141Ectopic kidney (HP:0000086)1.63502172
142Megalencephaly (HP:0001355)1.63490637
143Birth length less than 3rd percentile (HP:0003561)1.63383752
144Abnormality of the labia minora (HP:0012880)1.63320208
145Overgrowth (HP:0001548)1.62954720
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.62713265
147Rib fusion (HP:0000902)1.61848847
148Abnormal hair whorl (HP:0010721)1.61631127
149Keratoconus (HP:0000563)1.61461651
150Increased corneal curvature (HP:0100692)1.61461651
151Broad long bones (HP:0005622)1.60722799
152Cupped ear (HP:0000378)1.60642201
153Obsessive-compulsive behavior (HP:0000722)1.60562378
154Vitreoretinal degeneration (HP:0000655)1.60289165
155Neoplasm of the adrenal cortex (HP:0100641)1.60011000
156Long clavicles (HP:0000890)1.59677490
157Smooth philtrum (HP:0000319)1.59608919
158Excessive salivation (HP:0003781)1.59495888
159Hip contracture (HP:0003273)1.59059979
160Blepharitis (HP:0000498)1.58677369
161Nephroblastoma (Wilms tumor) (HP:0002667)1.57169226
162Buphthalmos (HP:0000557)1.56887330
163Long nose (HP:0003189)1.56601871
164Abnormality of the parathyroid morphology (HP:0011766)1.56358473
165Abnormality of chromosome segregation (HP:0002916)1.56330122
166Viral hepatitis (HP:0006562)1.55619803
167Bell-shaped thorax (HP:0001591)1.55450552
168Persistence of primary teeth (HP:0006335)1.52371057
169Renal duplication (HP:0000075)1.52338562
170Thin bony cortex (HP:0002753)1.51978596
171Absent eyebrow (HP:0002223)1.51566923
172Urethral obstruction (HP:0000796)1.50728024
173Uterine neoplasm (HP:0010784)1.50619711
174Neoplasm of the small intestine (HP:0100833)1.50586575
175Vertebral arch anomaly (HP:0008438)1.50040315
176Prominent nose (HP:0000448)1.49308162
177Breast carcinoma (HP:0003002)1.49302825
178T lymphocytopenia (HP:0005403)1.49287419
179Intestinal malrotation (HP:0002566)1.48640386
180Abnormality of the incisor (HP:0000676)1.48287374
181Atresia of the external auditory canal (HP:0000413)1.47992920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.61139371
2CDK123.24636612
3FRK2.96625157
4MKNK12.66126600
5STK32.39049218
6CDC72.25341125
7NUAK12.16540224
8MKNK22.14150260
9DMPK2.11524900
10ACVR1B1.99511808
11FGFR21.95460121
12MAP3K41.93519267
13BMPR1B1.83604293
14EEF2K1.78252252
15BRD41.72529388
16CDK61.71092935
17FGFR31.68360479
18PNCK1.64877929
19TEC1.61963949
20TAF11.60968488
21NEK21.59449810
22OXSR11.57223029
23CAMK1G1.53425036
24PDGFRB1.50961085
25AKT31.48429332
26EPHA31.48383476
27TNIK1.47805585
28BRSK21.42039706
29INSRR1.39131345
30PIK3CG1.37427289
31SRPK11.34165295
32CDK91.32579881
33CSNK1G11.32011635
34MAP3K71.30527988
35NEK91.29440459
36CSNK1A1L1.27456962
37MAP3K101.25694608
38PKN21.25506956
39PDGFRA1.25367514
40PTK61.24861635
41TGFBR11.23261511
42CAMKK21.21857161
43PASK1.19148489
44MELK1.19137317
45CASK1.19007408
46MTOR1.18312563
47WNK31.15068391
48MAP3K21.15048768
49KIT1.12830494
50ERBB31.12582972
51MAP2K41.10221939
52PLK31.08414331
53STK38L1.07957115
54HIPK21.07756755
55ATM1.06284572
56NLK1.05734590
57CDK191.04311373
58STK241.03172089
59WNK11.00489546
60ALK1.00092522
61MAPKAPK51.00023334
62CHEK10.99738802
63FGFR10.97651714
64EIF2AK30.97116293
65SGK30.97041488
66CAMK1D0.95032498
67SGK20.93971829
68OBSCN0.92105068
69IRAK10.91914293
70STK100.90218527
71CSNK1G30.90085497
72STK110.88520838
73PAK20.87867635
74TYRO30.86142532
75RPS6KA40.85934147
76PIK3CA0.85896683
77MARK30.85129872
78DYRK30.84984328
79ATR0.83618560
80MAPK150.81784815
81TRIB30.81663905
82TAOK30.81596010
83CHEK20.81298772
84NTRK20.81185345
85JAK30.80566146
86NTRK30.80454352
87CHUK0.78887396
88WNK40.78320098
89CDK40.77899751
90CSNK1G20.77662085
91CDK20.76379479
92MATK0.74188778
93RPS6KB20.73318073
94BMPR20.73260160
95STK390.72030736
96TXK0.71900895
97GRK10.71618263
98DDR20.71338574
99MAPK130.69695371
100AURKB0.69475916
101ERBB20.69354100
102SGK2230.66004880
103SGK4940.66004880
104PIM10.64627869
105TTK0.63146779
106LATS20.62872616
107PLK40.62829006
108CSNK1D0.62357176
109CSNK1E0.62154357
110PAK30.61603777
111TRPM70.60583998
112CDK10.60222876
113RPS6KB10.59803414
114* MAPK140.59769498
115CDK30.58263933
116RPS6KA60.57951518
117WEE10.56601743
118BTK0.56544443
119FLT30.56094228
120CCNB10.53416728
121MUSK0.53167987
122GSK3A0.52866635
123TSSK60.51721891
124PINK10.51128942
125MAPK100.51091677
126KSR10.50216953
127ITK0.49914709
128SGK10.48022155
129SIK10.47985150
130MAPK70.47790375
131AKT10.47504029
132CDK70.46889764
133RET0.46751878
134PRKDC0.46256983
135MAPK10.45770508
136ERBB40.45195239
137EGFR0.44865143
138ZAK0.44337245
139LRRK20.43932951
140GSK3B0.43052748
141RPS6KA50.42727128
142MAP3K140.41859237
143STK40.41450623
144MAP3K50.40938391
145YES10.40635187
146MAP3K60.40452917
147MAP4K10.40161474
148PRKACB0.39902340
149DYRK1A0.39096929
150PRKCQ0.38718652
151FER0.35575547
152PRKAA20.34724711
153PLK10.34364115
154CAMK40.34076928

Predicted pathways (KEGG)

RankGene SetZ-score
1Selenocompound metabolism_Homo sapiens_hsa004502.14931735
2MicroRNAs in cancer_Homo sapiens_hsa052061.96590196
3Cell cycle_Homo sapiens_hsa041101.85887845
4mRNA surveillance pathway_Homo sapiens_hsa030151.83771062
5Basal cell carcinoma_Homo sapiens_hsa052171.70636244
6Adherens junction_Homo sapiens_hsa045201.68812683
7Small cell lung cancer_Homo sapiens_hsa052221.64459005
8Non-homologous end-joining_Homo sapiens_hsa034501.64274064
9Prostate cancer_Homo sapiens_hsa052151.63019514
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61881524
11Transcriptional misregulation in cancer_Homo sapiens_hsa052021.61483768
12TGF-beta signaling pathway_Homo sapiens_hsa043501.60854227
13Chronic myeloid leukemia_Homo sapiens_hsa052201.59796178
14Colorectal cancer_Homo sapiens_hsa052101.58178058
15RNA transport_Homo sapiens_hsa030131.56827529
16Dorso-ventral axis formation_Homo sapiens_hsa043201.56057657
17Wnt signaling pathway_Homo sapiens_hsa043101.45352275
18Endometrial cancer_Homo sapiens_hsa052131.43946728
19Hippo signaling pathway_Homo sapiens_hsa043901.42463264
20RNA degradation_Homo sapiens_hsa030181.42372244
21ABC transporters_Homo sapiens_hsa020101.41916208
22Lysine degradation_Homo sapiens_hsa003101.39617900
23ECM-receptor interaction_Homo sapiens_hsa045121.39351280
24Pancreatic cancer_Homo sapiens_hsa052121.39295035
25Renal cell carcinoma_Homo sapiens_hsa052111.37909299
26Focal adhesion_Homo sapiens_hsa045101.37497530
27Taste transduction_Homo sapiens_hsa047421.35276813
28Proteoglycans in cancer_Homo sapiens_hsa052051.32378481
29Hedgehog signaling pathway_Homo sapiens_hsa043401.32304103
30Linoleic acid metabolism_Homo sapiens_hsa005911.31205619
31Spliceosome_Homo sapiens_hsa030401.27032546
32Thyroid cancer_Homo sapiens_hsa052161.27005417
33mTOR signaling pathway_Homo sapiens_hsa041501.26616722
34Nicotine addiction_Homo sapiens_hsa050331.21976557
35Non-small cell lung cancer_Homo sapiens_hsa052231.21581042
36T cell receptor signaling pathway_Homo sapiens_hsa046601.16966247
37Viral myocarditis_Homo sapiens_hsa054161.16067029
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15678754
39Pathways in cancer_Homo sapiens_hsa052001.14698901
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14365771
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14275758
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13460693
43HTLV-I infection_Homo sapiens_hsa051661.12172200
44Olfactory transduction_Homo sapiens_hsa047401.11425549
45Basal transcription factors_Homo sapiens_hsa030221.10989562
46FoxO signaling pathway_Homo sapiens_hsa040681.10972672
47Long-term depression_Homo sapiens_hsa047301.07000756
48Fanconi anemia pathway_Homo sapiens_hsa034601.06992565
49Viral carcinogenesis_Homo sapiens_hsa052031.06339914
50p53 signaling pathway_Homo sapiens_hsa041151.05380443
51Prolactin signaling pathway_Homo sapiens_hsa049171.05220490
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05220178
53Serotonergic synapse_Homo sapiens_hsa047261.04544835
54Platelet activation_Homo sapiens_hsa046111.03932980
55B cell receptor signaling pathway_Homo sapiens_hsa046621.03484832
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02059806
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97933802
58Acute myeloid leukemia_Homo sapiens_hsa052210.94758242
59Renin secretion_Homo sapiens_hsa049240.94670502
60Phototransduction_Homo sapiens_hsa047440.94610579
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94446467
62Toxoplasmosis_Homo sapiens_hsa051450.92892194
63cAMP signaling pathway_Homo sapiens_hsa040240.92793711
64Glioma_Homo sapiens_hsa052140.92096661
65PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91851286
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91279496
67Herpes simplex infection_Homo sapiens_hsa051680.90246430
68Nitrogen metabolism_Homo sapiens_hsa009100.89948824
69Ether lipid metabolism_Homo sapiens_hsa005650.89461043
70Circadian entrainment_Homo sapiens_hsa047130.89276735
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.89045676
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87543414
73Morphine addiction_Homo sapiens_hsa050320.86333914
74ErbB signaling pathway_Homo sapiens_hsa040120.86129805
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.85966477
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.85686634
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85243388
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.85227111
79Cholinergic synapse_Homo sapiens_hsa047250.85045778
80Tight junction_Homo sapiens_hsa045300.83862458
81Hepatitis B_Homo sapiens_hsa051610.83727455
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83290170
83Antigen processing and presentation_Homo sapiens_hsa046120.82255292
84Choline metabolism in cancer_Homo sapiens_hsa052310.81936494
85Oxytocin signaling pathway_Homo sapiens_hsa049210.81392212
86Oocyte meiosis_Homo sapiens_hsa041140.80602781
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80415121
88Axon guidance_Homo sapiens_hsa043600.80099239
89Estrogen signaling pathway_Homo sapiens_hsa049150.80000765
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79800481
91Melanoma_Homo sapiens_hsa052180.79513947
92Melanogenesis_Homo sapiens_hsa049160.79510638
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79366844
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.79277904
95Insulin resistance_Homo sapiens_hsa049310.78930705
96Glutamatergic synapse_Homo sapiens_hsa047240.78167587
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78163790
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.77582131
99Notch signaling pathway_Homo sapiens_hsa043300.75827674
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73812201
101Systemic lupus erythematosus_Homo sapiens_hsa053220.73652008
102Rap1 signaling pathway_Homo sapiens_hsa040150.73458794
103Mismatch repair_Homo sapiens_hsa034300.72416291
104Primary immunodeficiency_Homo sapiens_hsa053400.72019834
105Calcium signaling pathway_Homo sapiens_hsa040200.71599915
106Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71395923
107MAPK signaling pathway_Homo sapiens_hsa040100.71055144
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71046485
109Salivary secretion_Homo sapiens_hsa049700.70467659
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70059436
111Protein digestion and absorption_Homo sapiens_hsa049740.67987851
112Circadian rhythm_Homo sapiens_hsa047100.67569522
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67280538
114Regulation of autophagy_Homo sapiens_hsa041400.66848159
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66833338
116Type II diabetes mellitus_Homo sapiens_hsa049300.65951254
117Dopaminergic synapse_Homo sapiens_hsa047280.65508416
118Inositol phosphate metabolism_Homo sapiens_hsa005620.64930757
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64777971
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64526315
121Homologous recombination_Homo sapiens_hsa034400.64235287
122NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62858190
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62140488
124Ovarian steroidogenesis_Homo sapiens_hsa049130.61881153
125Ras signaling pathway_Homo sapiens_hsa040140.61510293
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61279198
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.60984400
128Measles_Homo sapiens_hsa051620.60610828
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60291367
130Hematopoietic cell lineage_Homo sapiens_hsa046400.59422078
131VEGF signaling pathway_Homo sapiens_hsa043700.59033158
132Amoebiasis_Homo sapiens_hsa051460.57685934
133Pancreatic secretion_Homo sapiens_hsa049720.56414879
134AMPK signaling pathway_Homo sapiens_hsa041520.56123298
135TNF signaling pathway_Homo sapiens_hsa046680.56019920
136African trypanosomiasis_Homo sapiens_hsa051430.56006479
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55368028
138Epstein-Barr virus infection_Homo sapiens_hsa051690.54012701
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53235176

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