SENP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.27095162
2doxorubicin metabolic process (GO:0044598)7.27095162
3daunorubicin metabolic process (GO:0044597)7.27095162
4protein localization to kinetochore (GO:0034501)5.26637434
5cullin deneddylation (GO:0010388)5.08579102
6negative regulation of epidermis development (GO:0045683)5.01890501
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.01031724
8mitotic sister chromatid segregation (GO:0000070)4.86136908
9maintenance of protein location in nucleus (GO:0051457)4.81770505
10protein deneddylation (GO:0000338)4.76576808
11piRNA metabolic process (GO:0034587)4.76263708
12regulation of nuclear cell cycle DNA replication (GO:0033262)4.63472702
13negative regulation of cell cycle G2/M phase transition (GO:1902750)4.60458027
14DNA replication checkpoint (GO:0000076)4.60007300
15aminoglycoside antibiotic metabolic process (GO:0030647)4.57919853
16somite rostral/caudal axis specification (GO:0032525)4.54768524
17regulation of cilium movement (GO:0003352)4.39405176
18rRNA transcription (GO:0009303)4.36873867
19rRNA methylation (GO:0031167)4.34461502
20regulation of telomere maintenance via telomerase (GO:0032210)4.33046582
21protein localization to chromosome, centromeric region (GO:0071459)4.32056688
22DNA replication-dependent nucleosome organization (GO:0034723)4.24841959
23DNA replication-dependent nucleosome assembly (GO:0006335)4.24841959
24synapsis (GO:0007129)4.15564898
25negative regulation of epidermal cell differentiation (GO:0045605)4.15028482
26rRNA modification (GO:0000154)4.10952715
27regulation of mammary gland epithelial cell proliferation (GO:0033599)4.04861327
28regulation of meiosis I (GO:0060631)3.99615450
29regulation of response to osmotic stress (GO:0047484)3.99520902
30phenol-containing compound catabolic process (GO:0019336)3.92952062
31sister chromatid segregation (GO:0000819)3.90214806
32quinone metabolic process (GO:1901661)3.89481070
33water-soluble vitamin biosynthetic process (GO:0042364)3.89186841
34respiratory chain complex IV assembly (GO:0008535)3.84693415
35protein polyglutamylation (GO:0018095)3.84605405
36behavioral response to nicotine (GO:0035095)3.81662130
37histone H4-K12 acetylation (GO:0043983)3.73652365
38histone H4-K8 acetylation (GO:0043982)3.73597048
39histone H4-K5 acetylation (GO:0043981)3.73597048
40protein complex biogenesis (GO:0070271)3.72947970
41microtubule severing (GO:0051013)3.71997826
42cellular ketone body metabolic process (GO:0046950)3.68753090
43attachment of spindle microtubules to kinetochore (GO:0008608)3.67360774
44notochord development (GO:0030903)3.62087243
45negative regulation of telomerase activity (GO:0051974)3.60647445
46DNA methylation involved in gamete generation (GO:0043046)3.57498120
47mitotic chromosome condensation (GO:0007076)3.56802761
48positive regulation of DNA-dependent DNA replication (GO:2000105)3.56705282
49cytochrome complex assembly (GO:0017004)3.55298705
50preassembly of GPI anchor in ER membrane (GO:0016254)3.53855262
51tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52767425
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52767425
53ubiquinone metabolic process (GO:0006743)3.52204480
54mitochondrial respiratory chain complex assembly (GO:0033108)3.51305684
55DNA double-strand break processing (GO:0000729)3.51273339
56cytidine deamination (GO:0009972)3.50212856
57cytidine metabolic process (GO:0046087)3.50212856
58cytidine catabolic process (GO:0006216)3.50212856
59response to pheromone (GO:0019236)3.45832504
60regulation of translation in response to stress (GO:0043555)3.45251139
61epithelial cilium movement (GO:0003351)3.41272911
62negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.40627829
63L-fucose catabolic process (GO:0042355)3.40237352
64fucose catabolic process (GO:0019317)3.40237352
65L-fucose metabolic process (GO:0042354)3.40237352
66DNA damage response, detection of DNA damage (GO:0042769)3.38529792
67regulation of MHC class I biosynthetic process (GO:0045343)3.32172015
68DNA deamination (GO:0045006)3.30471327
69positive regulation of histone H3-K4 methylation (GO:0051571)3.24884755
70ketone body metabolic process (GO:1902224)3.22879482
71muscle organ morphogenesis (GO:0048644)3.22079419
72regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20802059
73negative regulation of telomere maintenance (GO:0032205)3.20191050
74GDP-mannose metabolic process (GO:0019673)3.19141048
75response to dietary excess (GO:0002021)3.17682695
76pseudouridine synthesis (GO:0001522)3.17464775
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.17161873
78acrosome reaction (GO:0007340)3.16812234
79protein-cofactor linkage (GO:0018065)3.14922734
80male meiosis I (GO:0007141)3.14670854
81RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.10025510
82multicellular organism reproduction (GO:0032504)3.09096190
83nuclear pore complex assembly (GO:0051292)3.06669504
84mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05393536
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.05393536
86NADH dehydrogenase complex assembly (GO:0010257)3.05393536
87axoneme assembly (GO:0035082)3.05221143
88male meiosis (GO:0007140)3.02330238
89cell fate commitment involved in formation of primary germ layer (GO:0060795)3.00930473
90DNA unwinding involved in DNA replication (GO:0006268)3.00307451
91CENP-A containing nucleosome assembly (GO:0034080)2.96123675
92coenzyme catabolic process (GO:0009109)2.95853485
93ribosome biogenesis (GO:0042254)2.95101759
94ribosomal small subunit biogenesis (GO:0042274)2.94436597
95indolalkylamine metabolic process (GO:0006586)2.93604435
96epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92376793
97detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.90974902
98regulation of microtubule-based movement (GO:0060632)2.90785253
99regulation of acrosome reaction (GO:0060046)2.90250651
100formation of translation preinitiation complex (GO:0001731)2.88149046
101mitochondrial DNA replication (GO:0006264)2.87293261
102mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.86582977
103heterochromatin organization (GO:0070828)2.85465183
104establishment of integrated proviral latency (GO:0075713)2.85380210
105somatic hypermutation of immunoglobulin genes (GO:0016446)2.85373768
106somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85373768
107nucleoside transmembrane transport (GO:1901642)2.85173616
108kynurenine metabolic process (GO:0070189)2.84808998
109chromatin assembly (GO:0031497)2.83825811
110DNA replication initiation (GO:0006270)2.82724803
111peptidyl-histidine modification (GO:0018202)2.82267798
112mitotic G2/M transition checkpoint (GO:0044818)2.81706472
113chromatin remodeling at centromere (GO:0031055)2.80964213
114nuclear pore organization (GO:0006999)2.80952793
115regulation of double-strand break repair via homologous recombination (GO:0010569)2.80081937
116negative regulation of DNA-dependent DNA replication (GO:2000104)2.79312827
117branched-chain amino acid catabolic process (GO:0009083)2.78003314
118maturation of 5.8S rRNA (GO:0000460)2.77949495
119retinal cone cell development (GO:0046549)2.77492368
120regulation of glucokinase activity (GO:0033131)2.76820335
121regulation of hexokinase activity (GO:1903299)2.76820335
122proteasome assembly (GO:0043248)2.75666668
123reciprocal meiotic recombination (GO:0007131)2.75363487
124reciprocal DNA recombination (GO:0035825)2.75363487
125tryptophan catabolic process (GO:0006569)2.74295463
126indole-containing compound catabolic process (GO:0042436)2.74295463
127indolalkylamine catabolic process (GO:0046218)2.74295463
128kidney morphogenesis (GO:0060993)2.73988733
129photoreceptor cell maintenance (GO:0045494)2.72784948
130mitochondrial RNA metabolic process (GO:0000959)2.71469101
131positive regulation of mitotic sister chromatid separation (GO:1901970)2.71120686
132positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71120686
133positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71120686
134protein K6-linked ubiquitination (GO:0085020)2.70587077
135positive regulation of meiosis (GO:0045836)2.70465397
136cilium morphogenesis (GO:0060271)2.70179412
137GPI anchor metabolic process (GO:0006505)2.69754121
138cilium organization (GO:0044782)2.69530713
139sperm-egg recognition (GO:0035036)2.68017407
140cilium movement (GO:0003341)2.68007690
141primitive streak formation (GO:0090009)2.67632499
142regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66997065
143regulation of mitotic spindle checkpoint (GO:1903504)2.66997065
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.66910951
145platelet dense granule organization (GO:0060155)2.66831304
146recombinational repair (GO:0000725)2.66388383
147intraciliary transport (GO:0042073)2.65483746
148mannosylation (GO:0097502)2.65123847
149double-strand break repair via homologous recombination (GO:0000724)2.64431959
150regulation of telomerase activity (GO:0051972)2.63771308
151sperm motility (GO:0030317)2.63065301
152spindle assembly checkpoint (GO:0071173)2.61873557
153histone H4-K16 acetylation (GO:0043984)2.61352522
154cilium assembly (GO:0042384)2.61331634
155regulation of double-strand break repair (GO:2000779)2.60198090
156regulation of telomere maintenance (GO:0032204)2.59577299
157spindle checkpoint (GO:0031577)2.59354315
158establishment of melanosome localization (GO:0032401)2.59236151
159pre-miRNA processing (GO:0031054)2.58957802
160ribonucleoprotein complex biogenesis (GO:0022613)2.55315382
161DNA replication-independent nucleosome assembly (GO:0006336)2.54862974
162DNA replication-independent nucleosome organization (GO:0034724)2.54862974
163melanosome transport (GO:0032402)2.54751476
164positive regulation of meiotic cell cycle (GO:0051446)2.54352458
165negative regulation of cytosolic calcium ion concentration (GO:0051481)2.53895846
166inositol phosphate catabolic process (GO:0071545)2.53702871
167nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52315327
168pteridine-containing compound biosynthetic process (GO:0042559)2.51541946
169protein neddylation (GO:0045116)2.50885835
170magnesium ion transport (GO:0015693)2.50702020
171dopamine transport (GO:0015872)2.50610887
172nonmotile primary cilium assembly (GO:0035058)2.50600500
173regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.50456150
174tryptophan metabolic process (GO:0006568)2.50417099
175L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.50110181
176negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49909755
177mitotic metaphase plate congression (GO:0007080)2.49816300
178interferon-gamma production (GO:0032609)2.48995745
179cellular component biogenesis (GO:0044085)2.48790103
180phosphorylated carbohydrate dephosphorylation (GO:0046838)2.48412382
181inositol phosphate dephosphorylation (GO:0046855)2.48412382
182meiotic cell cycle (GO:0051321)2.48339498
183spinal cord motor neuron differentiation (GO:0021522)2.48203498
184histone exchange (GO:0043486)2.48111716
185protein K11-linked deubiquitination (GO:0035871)2.47801851
186negative regulation of mitotic sister chromatid segregation (GO:0033048)2.47532162
187spermatid development (GO:0007286)2.40878246
188metallo-sulfur cluster assembly (GO:0031163)2.40827433
189iron-sulfur cluster assembly (GO:0016226)2.40827433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.07228231
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.85448229
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.71020433
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.17580431
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.17580431
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.17580431
7ZNF274_21170338_ChIP-Seq_K562_Hela3.80036342
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.69069642
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36149285
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.17582635
11VDR_22108803_ChIP-Seq_LS180_Human3.14272433
12EZH2_22144423_ChIP-Seq_EOC_Human3.00226535
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99764286
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.96679537
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.88238473
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.78174348
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.76435652
18GBX2_23144817_ChIP-Seq_PC3_Human2.74194748
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70294134
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60700300
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41727424
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37460906
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36583667
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36384385
25EWS_26573619_Chip-Seq_HEK293_Human2.30577030
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18882812
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.16152320
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15964273
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.14077415
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12008704
31TAF15_26573619_Chip-Seq_HEK293_Human2.09102731
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07957323
33CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05333259
34IRF1_19129219_ChIP-ChIP_H3396_Human2.01425590
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01074039
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98766212
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98334532
38ER_23166858_ChIP-Seq_MCF-7_Human1.96694839
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.94610951
40P300_19829295_ChIP-Seq_ESCs_Human1.93943981
41NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.93007945
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91424509
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.91009058
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90416520
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86213013
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.84479405
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81375640
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80734208
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76686031
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.75688010
51SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75625953
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75171078
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74775662
54IGF1R_20145208_ChIP-Seq_DFB_Human1.73965619
55NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.71673667
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.68280730
57* NOTCH1_21737748_ChIP-Seq_TLL_Human1.67818620
58FOXP3_21729870_ChIP-Seq_TREG_Human1.67768124
59VDR_23849224_ChIP-Seq_CD4+_Human1.67551902
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65348971
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65338504
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64685851
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.63248457
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63087465
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62728769
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61152483
67TP53_22573176_ChIP-Seq_HFKS_Human1.58871488
68* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57470141
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55706203
70CBP_20019798_ChIP-Seq_JUKART_Human1.55706203
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54690941
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51929433
73AR_21909140_ChIP-Seq_LNCAP_Human1.51550843
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50661169
75* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49748480
76SMAD4_21799915_ChIP-Seq_A2780_Human1.49072694
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48325502
78XRN2_22483619_ChIP-Seq_HELA_Human1.47996304
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45718098
80STAT3_23295773_ChIP-Seq_U87_Human1.45551186
81* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41549637
82TTF2_22483619_ChIP-Seq_HELA_Human1.41202151
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39980780
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39676478
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39047550
86SOX2_19829295_ChIP-Seq_ESCs_Human1.38741177
87NANOG_19829295_ChIP-Seq_ESCs_Human1.38741177
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38484103
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38261317
90BCAT_22108803_ChIP-Seq_LS180_Human1.37066200
91ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36693861
92GABP_19822575_ChIP-Seq_HepG2_Human1.36374092
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34026891
94* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33983454
95FOXA1_25329375_ChIP-Seq_VCAP_Human1.33784064
96FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33784064
97TCF4_23295773_ChIP-Seq_U87_Human1.33733850
98* AR_25329375_ChIP-Seq_VCAP_Human1.33640265
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33445616
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33301382
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32693250
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.32014643
103ELK1_19687146_ChIP-ChIP_HELA_Human1.31548428
104DCP1A_22483619_ChIP-Seq_HELA_Human1.31447720
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30865585
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30865585
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30231688
108RNF2_27304074_Chip-Seq_NSC_Mouse1.28247685
109* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26593749
110PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26006346
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23700964
112PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23554585
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.19971342
114* SRF_21415370_ChIP-Seq_HL-1_Mouse1.19230166
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18705330
116E2F1_17053090_ChIP-ChIP_MCF-7_Human1.18499267
117AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18165821
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17893313
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.17715337
120EZH2_27294783_Chip-Seq_NPCs_Mouse1.17322104
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.17146398
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17038190
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16584610
124RUNX2_22187159_ChIP-Seq_PCA_Human1.16310351
125NANOG_16153702_ChIP-ChIP_HESCs_Human1.16088459
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16028023
127ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15960980
128ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15261031
129TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14881946
130SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14550674
131TCF4_22108803_ChIP-Seq_LS180_Human1.14284923
132AR_20517297_ChIP-Seq_VCAP_Human1.13478287
133* SOX2_16153702_ChIP-ChIP_HESCs_Human1.13036904
134FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12128754
135NCOR_22424771_ChIP-Seq_293T_Human1.10691196
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10298343
137MYC_18940864_ChIP-ChIP_HL60_Human1.09996050
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.08752789
139CDX2_22108803_ChIP-Seq_LS180_Human1.08742280
140HOXB7_26014856_ChIP-Seq_BT474_Human1.07120373
141GATA3_21878914_ChIP-Seq_MCF-7_Human1.06984863
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06733841
143NFE2_27457419_Chip-Seq_LIVER_Mouse1.06194167
144* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05972466
145NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05492435
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04646367
147POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04552141
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04255921
149CBX2_27304074_Chip-Seq_ESCs_Mouse1.03693629
150SALL1_21062744_ChIP-ChIP_HESCs_Human1.02709196
151HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02354137
152NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02039302
153PRDM14_20953172_ChIP-Seq_ESCs_Human1.01855878
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01842911
155BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00463782
156CRX_20693478_ChIP-Seq_RETINA_Mouse1.00135728
157CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97810680
158GATA1_26923725_Chip-Seq_HPCs_Mouse0.96307987
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.95970101
160POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95949859
161FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95884981
162KDM5A_27292631_Chip-Seq_BREAST_Human0.95701596
163HTT_18923047_ChIP-ChIP_STHdh_Human0.95067553
164* FOXH1_21741376_ChIP-Seq_EPCs_Human0.94830488
165FUS_26573619_Chip-Seq_HEK293_Human0.94411876
166SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93382916
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.92730619
168TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90338745
169ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88880627
170KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87106196
171KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86647397
172E2F1_21310950_ChIP-Seq_MCF-7_Human0.86099866
173FLI1_27457419_Chip-Seq_LIVER_Mouse0.85686338
174OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84045722
175SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.82388068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.55591744
2MP0008057_abnormal_DNA_replication3.70349712
3MP0003122_maternal_imprinting3.65649358
4MP0003121_genomic_imprinting3.34999130
5MP0004957_abnormal_blastocyst_morpholog3.33509585
6MP0003890_abnormal_embryonic-extraembry2.97797185
7MP0004264_abnormal_extraembryonic_tissu2.96158591
8MP0005394_taste/olfaction_phenotype2.91148691
9MP0005499_abnormal_olfactory_system2.91148691
10MP0003011_delayed_dark_adaptation2.90483490
11MP0003195_calcinosis2.55736640
12MP0002837_dystrophic_cardiac_calcinosis2.50288115
13MP0003183_abnormal_peptide_metabolism2.45834755
14MP0003123_paternal_imprinting2.43314384
15MP0003646_muscle_fatigue2.36093235
16MP0009379_abnormal_foot_pigmentation2.33918151
17MP0003787_abnormal_imprinting2.33192433
18MP0008877_abnormal_DNA_methylation2.27869711
19MP0006035_abnormal_mitochondrial_morpho2.15199074
20MP0002332_abnormal_exercise_endurance2.14246517
21MP0005075_abnormal_melanosome_morpholog2.13787710
22MP0005174_abnormal_tail_pigmentation2.13505540
23MP0010094_abnormal_chromosome_stability2.12481714
24MP0003077_abnormal_cell_cycle2.08178174
25MP0001188_hyperpigmentation2.07377209
26MP0008932_abnormal_embryonic_tissue2.04696015
27MP0005646_abnormal_pituitary_gland2.03179346
28MP0002653_abnormal_ependyma_morphology1.97204255
29MP0005551_abnormal_eye_electrophysiolog1.94036580
30MP0002638_abnormal_pupillary_reflex1.93853876
31MP0001968_abnormal_touch/_nociception1.93338827
32MP0002138_abnormal_hepatobiliary_system1.89096639
33MP0005645_abnormal_hypothalamus_physiol1.85930964
34MP0008789_abnormal_olfactory_epithelium1.78858038
35MP0010030_abnormal_orbit_morphology1.73821900
36MP0003693_abnormal_embryo_hatching1.73159366
37MP0002160_abnormal_reproductive_system1.72425111
38MP0002876_abnormal_thyroid_physiology1.70066546
39MP0001984_abnormal_olfaction1.62534074
40MP0001529_abnormal_vocalization1.62383577
41MP0003718_maternal_effect1.61364038
42MP0002272_abnormal_nervous_system1.60251147
43MP0005187_abnormal_penis_morphology1.59885341
44MP0000049_abnormal_middle_ear1.58089256
45MP0000569_abnormal_digit_pigmentation1.57888131
46MP0003315_abnormal_perineum_morphology1.57474031
47MP0003938_abnormal_ear_development1.57431127
48MP0000678_abnormal_parathyroid_gland1.55053273
49MP0009046_muscle_twitch1.52415128
50MP0000383_abnormal_hair_follicle1.50768853
51MP0005389_reproductive_system_phenotype1.48877081
52MP0001905_abnormal_dopamine_level1.48480740
53MP0004858_abnormal_nervous_system1.47916284
54MP0002736_abnormal_nociception_after1.43699308
55MP0005410_abnormal_fertilization1.42488636
56MP0009745_abnormal_behavioral_response1.42067434
57MP0003111_abnormal_nucleus_morphology1.41964186
58MP0002751_abnormal_autonomic_nervous1.41582623
59MP0004145_abnormal_muscle_electrophysio1.40579742
60MP0001672_abnormal_embryogenesis/_devel1.40320624
61MP0005380_embryogenesis_phenotype1.40320624
62MP0010386_abnormal_urinary_bladder1.39050865
63MP0002254_reproductive_system_inflammat1.36960157
64MP0000427_abnormal_hair_cycle1.35687866
65MP0005257_abnormal_intraocular_pressure1.33993432
66MP0005084_abnormal_gallbladder_morpholo1.33412708
67MP0002234_abnormal_pharynx_morphology1.31117370
68MP0008872_abnormal_physiological_respon1.30085963
69MP0002127_abnormal_cardiovascular_syste1.28594028
70MP0002233_abnormal_nose_morphology1.27150984
71MP0001293_anophthalmia1.26964165
72MP0003937_abnormal_limbs/digits/tail_de1.26604875
73MP0001485_abnormal_pinna_reflex1.25185512
74MP0004043_abnormal_pH_regulation1.24731853
75MP0002085_abnormal_embryonic_tissue1.24640834
76MP0000350_abnormal_cell_proliferation1.23634400
77MP0003698_abnormal_male_reproductive1.22488759
78MP0003984_embryonic_growth_retardation1.22264671
79MP0000647_abnormal_sebaceous_gland1.21835092
80MP0002088_abnormal_embryonic_growth/wei1.21702564
81MP0000762_abnormal_tongue_morphology1.20712067
82MP0000015_abnormal_ear_pigmentation1.19843132
83MP0006072_abnormal_retinal_apoptosis1.17827015
84MP0008007_abnormal_cellular_replicative1.17610578
85MP0008058_abnormal_DNA_repair1.17599830
86MP0006036_abnormal_mitochondrial_physio1.17525735
87MP0000631_abnormal_neuroendocrine_gland1.16745688
88MP0001501_abnormal_sleep_pattern1.15100307
89MP0002095_abnormal_skin_pigmentation1.14968218
90MP0000653_abnormal_sex_gland1.13604914
91MP0004133_heterotaxia1.12615844
92MP0004147_increased_porphyrin_level1.10885553
93MP0002277_abnormal_respiratory_mucosa1.10828974
94MP0005266_abnormal_metabolism1.10661953
95MP0001919_abnormal_reproductive_system1.10563771
96MP0002084_abnormal_developmental_patter1.10269873
97MP0004885_abnormal_endolymph1.10238025
98MP0008995_early_reproductive_senescence1.09919225
99MP0001486_abnormal_startle_reflex1.09687641
100MP0002932_abnormal_joint_morphology1.08005197
101MP0004270_analgesia1.07018474
102MP0001730_embryonic_growth_arrest1.06642281
103MP0008875_abnormal_xenobiotic_pharmacok1.06169347
104MP0002114_abnormal_axial_skeleton1.05961580
105MP0003755_abnormal_palate_morphology1.04656639
106MP0001697_abnormal_embryo_size1.01731744
107MP0002928_abnormal_bile_duct1.01497907
108MP0008775_abnormal_heart_ventricle0.98787024
109MP0002557_abnormal_social/conspecific_i0.98684261
110MP0005379_endocrine/exocrine_gland_phen0.98172285
111MP0010678_abnormal_skin_adnexa0.97268925
112MP0003137_abnormal_impulse_conducting0.96220657
113MP0003786_premature_aging0.95454065
114MP0001764_abnormal_homeostasis0.93962209
115MP0003880_abnormal_central_pattern0.93906364
116MP0006276_abnormal_autonomic_nervous0.92107507
117MP0003806_abnormal_nucleotide_metabolis0.90126615
118MP0005253_abnormal_eye_physiology0.90117636
119MP0002092_abnormal_eye_morphology0.89588941
120MP0005332_abnormal_amino_acid0.89524661
121MP0010352_gastrointestinal_tract_polyps0.88332961
122MP0001986_abnormal_taste_sensitivity0.87982412
123MP0000372_irregular_coat_pigmentation0.87862262
124MP0000428_abnormal_craniofacial_morphol0.87726393
125MP0002249_abnormal_larynx_morphology0.86900624
126MP0002572_abnormal_emotion/affect_behav0.86172599
127MP0004142_abnormal_muscle_tone0.86010458
128MP0000749_muscle_degeneration0.85322780
129MP0004215_abnormal_myocardial_fiber0.85022853
130MP0005391_vision/eye_phenotype0.84851718
131MP0002067_abnormal_sensory_capabilities0.81721080
132MP0000432_abnormal_head_morphology0.81424074
133MP0002752_abnormal_somatic_nervous0.81099532
134MP0000313_abnormal_cell_death0.79939755
135MP0002163_abnormal_gland_morphology0.79205589
136MP0003935_abnormal_craniofacial_develop0.79007040
137MP0004924_abnormal_behavior0.78735681
138MP0005386_behavior/neurological_phenoty0.78735681
139MP0005395_other_phenotype0.78536774
140MP0001929_abnormal_gametogenesis0.78041451
141MP0005367_renal/urinary_system_phenotyp0.78035836
142MP0000516_abnormal_urinary_system0.78035836
143MP0002396_abnormal_hematopoietic_system0.77663685
144MP0000358_abnormal_cell_content/0.77098986
145MP0002080_prenatal_lethality0.76871862
146MP0003136_yellow_coat_color0.76564481
147MP0005195_abnormal_posterior_eye0.75100869
148MP0005167_abnormal_blood-brain_barrier0.74545785
149MP0002229_neurodegeneration0.74252554
150MP0002938_white_spotting0.73990861
151MP0002210_abnormal_sex_determination0.72982902
152MP0003861_abnormal_nervous_system0.72703298
153MP0002877_abnormal_melanocyte_morpholog0.72500027
154MP0001145_abnormal_male_reproductive0.70874568
155MP0002116_abnormal_craniofacial_bone0.70665345
156MP0001286_abnormal_eye_development0.70204098
157MP0001270_distended_abdomen0.69960961
158MP0003950_abnormal_plasma_membrane0.68606073
159MP0002086_abnormal_extraembryonic_tissu0.68298142
160MP0000955_abnormal_spinal_cord0.66891219
161MP0002102_abnormal_ear_morphology0.66525421
162MP0001849_ear_inflammation0.66345538

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.20808430
2Pancreatic cysts (HP:0001737)4.25609534
3Pancreatic fibrosis (HP:0100732)3.93267273
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.91875253
5Increased serum pyruvate (HP:0003542)3.79481252
6Abnormality of glycolysis (HP:0004366)3.79481252
7Nephroblastoma (Wilms tumor) (HP:0002667)3.74013475
8Hypochromic microcytic anemia (HP:0004840)3.66766437
9True hermaphroditism (HP:0010459)3.66063077
10Chromsome breakage (HP:0040012)3.65443402
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.60362096
12Hypoplasia of the fovea (HP:0007750)3.60362096
13Partial duplication of thumb phalanx (HP:0009944)3.50962035
14Rectovaginal fistula (HP:0000143)3.50470535
15Rectal fistula (HP:0100590)3.50470535
16Embryonal renal neoplasm (HP:0011794)3.48554523
17Bifid tongue (HP:0010297)3.42911391
18Rib fusion (HP:0000902)3.40375753
19Multiple enchondromatosis (HP:0005701)3.35234954
20Nephronophthisis (HP:0000090)3.35123390
213-Methylglutaconic aciduria (HP:0003535)3.33518662
22Aplastic anemia (HP:0001915)3.32495741
23Ependymoma (HP:0002888)3.27143665
24Hepatoblastoma (HP:0002884)3.23119565
25Rhabdomyosarcoma (HP:0002859)3.20340183
26Supernumerary spleens (HP:0009799)3.12707590
27Neoplasm of striated muscle (HP:0009728)3.11196763
28Partial duplication of the phalanx of hand (HP:0009999)3.05141900
29Medial flaring of the eyebrow (HP:0010747)3.04633652
30Methylmalonic acidemia (HP:0002912)3.01576204
31Intestinal fistula (HP:0100819)2.96125422
32Abnormality of the fovea (HP:0000493)2.88584996
33Vaginal fistula (HP:0004320)2.87431456
34Bile duct proliferation (HP:0001408)2.81349297
35Abnormal biliary tract physiology (HP:0012439)2.81349297
36Nasolacrimal duct obstruction (HP:0000579)2.81047473
37Abnormality of the renal medulla (HP:0100957)2.81038907
38Abnormality of the renal cortex (HP:0011035)2.76896085
39Abnormality of the salivary glands (HP:0010286)2.76363215
40Type II lissencephaly (HP:0007260)2.75645627
41Abnormal lung lobation (HP:0002101)2.69450052
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66437158
43Abolished electroretinogram (ERG) (HP:0000550)2.66229877
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.65530445
45Abnormality of chromosome segregation (HP:0002916)2.61494770
46Hypothermia (HP:0002045)2.59419594
47Progressive macrocephaly (HP:0004481)2.54346376
48Duplication of thumb phalanx (HP:0009942)2.52845384
49Acute encephalopathy (HP:0006846)2.51889649
50Hepatic necrosis (HP:0002605)2.50226763
51Congenital stationary night blindness (HP:0007642)2.49704559
52Abnormality of the phalanges of the hallux (HP:0010057)2.49410110
53Chronic hepatic failure (HP:0100626)2.48678187
54Hepatocellular necrosis (HP:0001404)2.44371946
55Colon cancer (HP:0003003)2.42982848
56Fused cervical vertebrae (HP:0002949)2.38871569
57Attenuation of retinal blood vessels (HP:0007843)2.38204526
58Acute necrotizing encephalopathy (HP:0006965)2.36551285
59Type I transferrin isoform profile (HP:0003642)2.35824336
60Hyperalaninemia (HP:0003348)2.33975325
61Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33975325
62Abnormality of alanine metabolism (HP:0010916)2.33975325
63Cystic liver disease (HP:0006706)2.33490845
64Lipid accumulation in hepatocytes (HP:0006561)2.33199982
65Methylmalonic aciduria (HP:0012120)2.32706069
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31932825
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31932825
68Sclerocornea (HP:0000647)2.31320375
69Hyperinsulinemic hypoglycemia (HP:0000825)2.30455917
70Microretrognathia (HP:0000308)2.29673573
71Anomalous pulmonary venous return (HP:0010772)2.29384258
72Ragged-red muscle fibers (HP:0003200)2.28889309
73Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28688137
74Molar tooth sign on MRI (HP:0002419)2.28385324
75Abnormality of midbrain morphology (HP:0002418)2.28385324
76Aplasia/hypoplasia of the humerus (HP:0006507)2.28264604
77Meckel diverticulum (HP:0002245)2.28194557
78Abnormality of the astrocytes (HP:0100707)2.26785669
79Astrocytoma (HP:0009592)2.26785669
80Congenital hepatic fibrosis (HP:0002612)2.25813879
81Sensory axonal neuropathy (HP:0003390)2.25231885
82Polydipsia (HP:0001959)2.22764860
83Abnormal drinking behavior (HP:0030082)2.22764860
84Tubular atrophy (HP:0000092)2.22542980
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.21827920
86Hyperventilation (HP:0002883)2.21207508
87Large for gestational age (HP:0001520)2.20685803
88Nephrogenic diabetes insipidus (HP:0009806)2.19843154
89Renal cortical cysts (HP:0000803)2.19734611
90Progressive muscle weakness (HP:0003323)2.19287862
91Abnormality of the ileum (HP:0001549)2.19190221
92Gaze-evoked nystagmus (HP:0000640)2.18748235
93Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.17753936
94Short humerus (HP:0005792)2.16363646
95Hyperglycinemia (HP:0002154)2.15576394
96Testicular atrophy (HP:0000029)2.15114172
97Renal Fanconi syndrome (HP:0001994)2.14799174
98Anencephaly (HP:0002323)2.14722487
99Aplasia/Hypoplasia of the tibia (HP:0005772)2.13776957
100Aplasia/Hypoplasia of the sacrum (HP:0008517)2.12699397
101Preauricular pit (HP:0004467)2.11689324
102Periauricular skin pits (HP:0100277)2.11689324
103Abnormality of the lacrimal duct (HP:0011481)2.10829189
104Neonatal respiratory distress (HP:0002643)2.09405138
105Abnormality of the labia minora (HP:0012880)2.07443886
106Generalized hypotonia (HP:0001290)2.05826579
107Male pseudohermaphroditism (HP:0000037)2.04926223
108Trismus (HP:0000211)2.03564874
109Increased CSF lactate (HP:0002490)2.02822261
110Impulsivity (HP:0100710)2.02503083
111Duodenal stenosis (HP:0100867)2.01480045
112Small intestinal stenosis (HP:0012848)2.01480045
113Embryonal neoplasm (HP:0002898)2.00937444
114Broad foot (HP:0001769)2.00607796
115Aplasia/hypoplasia of the uterus (HP:0008684)2.00180677
116Abnormality of macular pigmentation (HP:0008002)2.00169364
117Pendular nystagmus (HP:0012043)1.99598580
118Sloping forehead (HP:0000340)1.99590576
119Abnormality of vitamin B metabolism (HP:0004340)1.99215374
120Horizontal nystagmus (HP:0000666)1.97037911
121Abnormal mitochondria in muscle tissue (HP:0008316)1.96571660
122Flat capital femoral epiphysis (HP:0003370)1.96117836
123Abnormality of the lower motor neuron (HP:0002366)1.95906928
124Absent/shortened dynein arms (HP:0200106)1.95356573
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.95356573
126Abnormality of the corticospinal tract (HP:0002492)1.93927640
127Hypoplasia of the uterus (HP:0000013)1.93536765
128Furrowed tongue (HP:0000221)1.93264143
129Short tibia (HP:0005736)1.93262848
130Aplasia/Hypoplasia of the macula (HP:0008059)1.92917498
131Genital tract atresia (HP:0001827)1.92536989
132Increased hepatocellular lipid droplets (HP:0006565)1.91662011
133Abnormality of urine glucose concentration (HP:0011016)1.91649283
134Glycosuria (HP:0003076)1.91649283
135Increased serum lactate (HP:0002151)1.91631732
136Medulloblastoma (HP:0002885)1.91333893
137Preaxial foot polydactyly (HP:0001841)1.91055384
138Cerebral edema (HP:0002181)1.91049326
139Lactic acidosis (HP:0003128)1.90753704
140Abnormality of the duodenum (HP:0002246)1.90496121
141Ketoacidosis (HP:0001993)1.90267923
142Reduced antithrombin III activity (HP:0001976)1.88890613
143Abnormal rod and cone electroretinograms (HP:0008323)1.88762610
144Thyroid-stimulating hormone excess (HP:0002925)1.87946727
145Cerebellar dysplasia (HP:0007033)1.87760873
146Abnormality of the pons (HP:0007361)1.87630454
147Microvesicular hepatic steatosis (HP:0001414)1.86967504
148Mitochondrial inheritance (HP:0001427)1.86673351
149Postaxial foot polydactyly (HP:0001830)1.86414801
150Optic nerve hypoplasia (HP:0000609)1.86385059
151Amyotrophic lateral sclerosis (HP:0007354)1.86166402
152Broad alveolar ridges (HP:0000187)1.84770361
153Progressive external ophthalmoplegia (HP:0000590)1.84425747
154Occipital encephalocele (HP:0002085)1.83355605
155Abnormality of the pulmonary veins (HP:0011718)1.83286288
156Ketosis (HP:0001946)1.82839891
157Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81957126
158Lissencephaly (HP:0001339)1.80924925
159Preauricular skin tag (HP:0000384)1.80170828
160Gait imbalance (HP:0002141)1.80039159
161Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79816466
162Lethargy (HP:0001254)1.78656422
163Vaginal atresia (HP:0000148)1.78613629
164Aplasia/Hypoplasia affecting the retina (HP:0008061)1.78346530
165Prominent occiput (HP:0000269)1.78247490
166Congenital primary aphakia (HP:0007707)1.78076559
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77708243
168Azoospermia (HP:0000027)1.77620295
169Myelodysplasia (HP:0002863)1.77487311
170Inability to walk (HP:0002540)1.77467516
171Triphalangeal thumb (HP:0001199)1.77360793
172Abnormality of the nasolacrimal system (HP:0000614)1.76594817
173Hypoplasia of the pons (HP:0012110)1.76407899
174Progressive inability to walk (HP:0002505)1.76381386
175Metaphyseal dysplasia (HP:0100255)1.76273118
176Ectopic anus (HP:0004397)1.75216009
177Atresia of the external auditory canal (HP:0000413)1.74952452
178Abnormality of glycosphingolipid metabolism (HP:0004343)1.74735325
179Polyuria (HP:0000103)1.74235712
180Optic disc pallor (HP:0000543)1.74064858
181Congenital, generalized hypertrichosis (HP:0004540)1.73464796
182Abnormality of the vitamin B12 metabolism (HP:0004341)1.71475205
183Abnormal respiratory motile cilium physiology (HP:0012261)1.71084852
184Postaxial hand polydactyly (HP:0001162)1.70755018

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.56549918
2GRK54.89302237
3FRK4.69650853
4PINK13.63759363
5TTK3.31508918
6ADRBK23.31007329
7MAP4K23.30621875
8ZAK2.79558942
9GRK72.70438993
10GRK62.66450431
11CDC72.43628343
12MOS2.42079978
13CSF1R2.34559456
14GRK12.33463239
15WNK42.32108881
16BUB12.31621803
17TRIM282.28068350
18TAOK31.99609041
19CHEK21.98361953
20STK101.89768065
21NUAK11.76229426
22TLK11.73115851
23MAP3K41.70515324
24STK38L1.63379377
25PLK11.59187197
26TGFBR21.59018797
27STK161.58297343
28MST41.57357909
29MKNK21.56830314
30WEE11.55805234
31ERN11.55045909
32PBK1.54733328
33WNK11.52293853
34MAPK71.51675536
35BCKDK1.47700521
36ADRBK11.46377159
37PLK21.44358516
38CDK71.43779079
39MAP2K41.40042077
40BRAF1.38327480
41DYRK21.34418273
42TNIK1.30690045
43OBSCN1.27215061
44MATK1.25300960
45TGFBR11.25261149
46AURKA1.22476648
47INSRR1.19314953
48MARK21.19072548
49TYRO31.15262605
50NTRK11.09803960
51ERBB31.08351444
52SRPK11.08176748
53ARAF1.06632735
54CDK81.06098916
55BCR1.05212132
56HIPK21.02316705
57DYRK31.02022182
58BRSK20.99049510
59TIE10.98933086
60CHEK10.97610722
61MELK0.97566780
62NME10.95629810
63LATS20.95407322
64PNCK0.94787425
65STK240.90576064
66PRKCE0.88965302
67MAPKAPK50.84065038
68VRK10.83796913
69PRKG20.82768995
70PHKG20.82438416
71PHKG10.82438416
72MAP3K60.81355074
73ACVR1B0.81266291
74MAP2K70.79952562
75DAPK20.78489804
76NEK10.78401754
77ERBB40.77921388
78PAK30.77100035
79VRK20.75003901
80PRKCG0.73444309
81CSNK1G30.72844843
82STK30.72393965
83BRSK10.70857460
84PLK40.69425476
85CAMK40.68128809
86STK390.67826318
87FLT30.67460584
88NEK20.64654806
89FGFR20.64597076
90MKNK10.63768396
91AURKB0.63170684
92NTRK30.63151883
93PIK3CA0.62452941
94ATM0.61896568
95RPS6KA50.60129115
96MUSK0.59050969
97AKT30.57733834
98EIF2AK30.57314156
99OXSR10.56613088
100MAPK130.55880110
101PRKCI0.55177336
102LIMK10.55048394
103ATR0.54851087
104EIF2AK20.54721716
105CSNK1A10.54433277
106CDK190.53646711
107PLK30.53333954
108CDK30.52225693
109CAMK2A0.51936273
110CDK20.51491850
111AKT20.50135210
112CDK180.49745001
113CDK150.49138901
114CDK10.47516749
115CDK140.47320271
116PTK2B0.46021523
117CASK0.45773117
118UHMK10.45685819
119PRKACA0.45631406
120EIF2AK10.45417810
121EPHA40.44178229
122MAP3K120.44166987
123CDK11A0.43941576
124TXK0.43099709
125MAPKAPK30.43089953
126CSNK1G20.42653416
127MAP3K90.41695420
128CSNK1E0.41591855
129TSSK60.41323216
130IKBKB0.40500813
131CAMK10.39526165
132CSNK1A1L0.38904104
133CSNK1D0.38503489
134TAF10.38065555
135PAK40.38011414
136MAPK100.37590622
137DYRK1A0.37103825
138BMPR1B0.36127980
139CSNK1G10.36063302
140PRKCQ0.35768327
141PRKG10.35484064
142CDK40.34786658
143PRKAA10.34138266
144YES10.32273566
145TEC0.32245213
146IGF1R0.32102850
147RPS6KA40.31946601
148PKN10.31872799
149WNK30.31283308
150MAP2K60.30604221
151PAK10.29022457
152CSNK2A10.26670343

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.92571400
2Vitamin B6 metabolism_Homo sapiens_hsa007503.64167196
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.19313404
4DNA replication_Homo sapiens_hsa030302.99041202
5Mismatch repair_Homo sapiens_hsa034302.86866792
6RNA polymerase_Homo sapiens_hsa030202.82213944
7Homologous recombination_Homo sapiens_hsa034402.62048637
8Basal transcription factors_Homo sapiens_hsa030222.61344954
9RNA degradation_Homo sapiens_hsa030182.51166806
10Oxidative phosphorylation_Homo sapiens_hsa001902.45476915
11Cell cycle_Homo sapiens_hsa041102.43277926
12RNA transport_Homo sapiens_hsa030132.30074222
13Proteasome_Homo sapiens_hsa030502.29735181
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24755003
15Ribosome_Homo sapiens_hsa030102.21551943
16Butanoate metabolism_Homo sapiens_hsa006502.18240243
17Propanoate metabolism_Homo sapiens_hsa006402.16824974
18Parkinsons disease_Homo sapiens_hsa050122.15803586
19Phototransduction_Homo sapiens_hsa047442.15009476
20Nucleotide excision repair_Homo sapiens_hsa034202.00193449
21Fanconi anemia pathway_Homo sapiens_hsa034601.98775178
22Linoleic acid metabolism_Homo sapiens_hsa005911.92329479
23Protein export_Homo sapiens_hsa030601.92116729
24Spliceosome_Homo sapiens_hsa030401.89053446
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85313186
26Huntingtons disease_Homo sapiens_hsa050161.79461010
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77939831
28Non-homologous end-joining_Homo sapiens_hsa034501.74575140
29Selenocompound metabolism_Homo sapiens_hsa004501.71038301
30Tryptophan metabolism_Homo sapiens_hsa003801.70509905
31Nitrogen metabolism_Homo sapiens_hsa009101.69759737
32Arachidonic acid metabolism_Homo sapiens_hsa005901.69368091
33Fructose and mannose metabolism_Homo sapiens_hsa000511.67125587
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.66131548
35Pyrimidine metabolism_Homo sapiens_hsa002401.64789676
36Ether lipid metabolism_Homo sapiens_hsa005651.62801601
37Base excision repair_Homo sapiens_hsa034101.61527744
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60084768
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48809994
40Alzheimers disease_Homo sapiens_hsa050101.44906379
41Peroxisome_Homo sapiens_hsa041461.42464826
42mRNA surveillance pathway_Homo sapiens_hsa030151.38914825
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28211377
44Thyroid cancer_Homo sapiens_hsa052161.25715626
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21478067
46Nicotine addiction_Homo sapiens_hsa050331.19087678
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14274384
48beta-Alanine metabolism_Homo sapiens_hsa004101.10713082
49Olfactory transduction_Homo sapiens_hsa047401.09274540
50Folate biosynthesis_Homo sapiens_hsa007901.08805495
51Caffeine metabolism_Homo sapiens_hsa002321.06238333
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04624847
53Ovarian steroidogenesis_Homo sapiens_hsa049131.03774277
54Oocyte meiosis_Homo sapiens_hsa041141.02597757
55Fatty acid degradation_Homo sapiens_hsa000711.02557636
56Serotonergic synapse_Homo sapiens_hsa047261.01869483
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00518917
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.94385349
59Purine metabolism_Homo sapiens_hsa002300.94286310
60Insulin secretion_Homo sapiens_hsa049110.92932517
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92012582
62Galactose metabolism_Homo sapiens_hsa000520.91458470
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90494887
64Cardiac muscle contraction_Homo sapiens_hsa042600.89430388
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88367757
66p53 signaling pathway_Homo sapiens_hsa041150.77548794
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76663200
68Taste transduction_Homo sapiens_hsa047420.76063456
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75345352
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74961654
71Steroid biosynthesis_Homo sapiens_hsa001000.74735004
72Sulfur metabolism_Homo sapiens_hsa009200.72740517
73Chemical carcinogenesis_Homo sapiens_hsa052040.71371456
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70266495
75Circadian rhythm_Homo sapiens_hsa047100.70027644
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69715117
77ABC transporters_Homo sapiens_hsa020100.69681338
78Collecting duct acid secretion_Homo sapiens_hsa049660.68157374
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68069353
80Retinol metabolism_Homo sapiens_hsa008300.67820020
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63911418
82Morphine addiction_Homo sapiens_hsa050320.63721342
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63284661
84Metabolic pathways_Homo sapiens_hsa011000.62030107
85Fatty acid metabolism_Homo sapiens_hsa012120.61966039
86One carbon pool by folate_Homo sapiens_hsa006700.59472923
87Fatty acid elongation_Homo sapiens_hsa000620.59211990
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58287874
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57205932
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57101180
91Arginine and proline metabolism_Homo sapiens_hsa003300.57047678
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56665528
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.55893408
94Circadian entrainment_Homo sapiens_hsa047130.55674410
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.53811965
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53217173
97Regulation of autophagy_Homo sapiens_hsa041400.51722779
98Salivary secretion_Homo sapiens_hsa049700.51608167
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49920672
100Other glycan degradation_Homo sapiens_hsa005110.48892965
101Hedgehog signaling pathway_Homo sapiens_hsa043400.48547475
102Histidine metabolism_Homo sapiens_hsa003400.47426466
103Vibrio cholerae infection_Homo sapiens_hsa051100.46467882
104Sphingolipid metabolism_Homo sapiens_hsa006000.45982532
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45936368
106Long-term depression_Homo sapiens_hsa047300.44578359
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.43632121
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42120095
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41306954
110Asthma_Homo sapiens_hsa053100.40747448
111Glutamatergic synapse_Homo sapiens_hsa047240.39398851
112GABAergic synapse_Homo sapiens_hsa047270.38525793
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.37484888
114Epstein-Barr virus infection_Homo sapiens_hsa051690.37431595
115Type I diabetes mellitus_Homo sapiens_hsa049400.37342930
116Pyruvate metabolism_Homo sapiens_hsa006200.37279543
117Pathways in cancer_Homo sapiens_hsa052000.37270616
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37183801
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33773754
120Inositol phosphate metabolism_Homo sapiens_hsa005620.33013138
121Basal cell carcinoma_Homo sapiens_hsa052170.29153917
122Pancreatic cancer_Homo sapiens_hsa052120.28426158
123mTOR signaling pathway_Homo sapiens_hsa041500.27846590
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27508489
125MicroRNAs in cancer_Homo sapiens_hsa052060.25573646
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.23702270
127Colorectal cancer_Homo sapiens_hsa052100.23468132
128Wnt signaling pathway_Homo sapiens_hsa043100.23187905
129Choline metabolism in cancer_Homo sapiens_hsa052310.22591952
130Ras signaling pathway_Homo sapiens_hsa040140.20926827
131Alcoholism_Homo sapiens_hsa050340.20276907
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19917386
133GnRH signaling pathway_Homo sapiens_hsa049120.19324375
134Viral carcinogenesis_Homo sapiens_hsa052030.17959917
135Dopaminergic synapse_Homo sapiens_hsa047280.16768778
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.16402024
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.16313114
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.15748816
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15121646
140TGF-beta signaling pathway_Homo sapiens_hsa043500.14926350
141Glutathione metabolism_Homo sapiens_hsa004800.14890905
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.14633789
143Synaptic vesicle cycle_Homo sapiens_hsa047210.13751264
144Non-small cell lung cancer_Homo sapiens_hsa052230.11662044
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.11645025

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »