ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	8.80241481
2	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	4.66436574
3	auditory behavior (GO:0031223)	4.64501374
4	cellular potassium ion homeostasis (GO:0030007)	4.63785017
5	central nervous system projection neuron axonogenesis (GO:0021952)	4.58645242
6	neuron cell-cell adhesion (GO:0007158)	4.46447398
7	maturation of SSU-rRNA (GO:0030490)	4.38577405
8	regulation of axon regeneration (GO:0048679)	4.21746815
9	regulation of neuron projection regeneration (GO:0070570)	4.21746815
10	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	4.20692287
11	pyrimidine nucleobase catabolic process (GO:0006208)	4.16869009
12	regulation of cilium movement (GO:0003352)	4.12016443
13	mechanosensory behavior (GO:0007638)	4.08682068
14	neurotransmitter-gated ion channel clustering (GO:0072578)	4.06319350
15	sodium ion export (GO:0071436)	4.03560272
16	postsynaptic membrane organization (GO:0001941)	4.00225961
17	neuron fate determination (GO:0048664)	3.86112714
18	protein polyglutamylation (GO:0018095)	3.80615771
19	dendritic spine morphogenesis (GO:0060997)	3.75718257
20	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.65361243
21	positive regulation of potassium ion transmembrane transport (GO:1901381)	3.62848909
22	establishment of mitochondrion localization (GO:0051654)	3.55078023
23	central nervous system neuron axonogenesis (GO:0021955)	3.53792450
24	presynaptic membrane assembly (GO:0097105)	3.48168872
25	cranial nerve morphogenesis (GO:0021602)	3.45434990
26	ribosomal small subunit assembly (GO:0000028)	3.44718260
27	regulation of synapse structural plasticity (GO:0051823)	3.43994797
28	cellular sodium ion homeostasis (GO:0006883)	3.41546008
29	positive regulation of respiratory burst (GO:0060267)	3.40749084
30	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.28467503
31	nucleobase catabolic process (GO:0046113)	3.27175332
32	presynaptic membrane organization (GO:0097090)	3.26462220
33	DNA damage response, detection of DNA damage (GO:0042769)	3.25140640
34	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.24152245
35	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.24152245
36	regulation of translation, ncRNA-mediated (GO:0045974)	3.24152245
37	cerebellar granule cell differentiation (GO:0021707)	3.23591934
38	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.22431155
39	locomotory exploration behavior (GO:0035641)	3.21987661
40	cell communication by electrical coupling (GO:0010644)	3.15805578
41	neuron recognition (GO:0008038)	3.13440064
42	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.11528891
43	retinal ganglion cell axon guidance (GO:0031290)	3.10085036
44	positive regulation of synapse assembly (GO:0051965)	3.07957075
45	synaptic transmission, glutamatergic (GO:0035249)	3.03555232
46	myelination in peripheral nervous system (GO:0022011)	3.03150714
47	peripheral nervous system axon ensheathment (GO:0032292)	3.03150714
48	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.99511748
49	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.99009784
50	protein localization to cilium (GO:0061512)	2.98055048
51	potassium ion import (GO:0010107)	2.96851707
52	exploration behavior (GO:0035640)	2.95734467
53	cellular response to leptin stimulus (GO:0044320)	2.95204437
54	protein localization to synapse (GO:0035418)	2.94078329
55	DNA integration (GO:0015074)	2.93637657
56	neuron remodeling (GO:0016322)	2.93537353
57	peptidyl-threonine dephosphorylation (GO:0035970)	2.92156047
58	brain morphogenesis (GO:0048854)	2.92113236
59	axonal fasciculation (GO:0007413)	2.90541450
60	regulation of microtubule-based movement (GO:0060632)	2.90455023
61	glutamate receptor signaling pathway (GO:0007215)	2.87828846
62	otic vesicle formation (GO:0030916)	2.84606833
63	regulation of sarcomere organization (GO:0060297)	2.83486513
64	cochlea development (GO:0090102)	2.82894792
65	gamma-aminobutyric acid transport (GO:0015812)	2.81502285
66	regulation of transmission of nerve impulse (GO:0051969)	2.76386766
67	protein complex biogenesis (GO:0070271)	2.75581503
68	regulation of synapse assembly (GO:0051963)	2.74874107
69	histone H2A acetylation (GO:0043968)	2.74222398
70	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.73976167
71	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.73458092
72	cAMP-mediated signaling (GO:0019933)	2.73298075
73	response to auditory stimulus (GO:0010996)	2.71281452
74	neural tube formation (GO:0001841)	2.69413378
75	mitochondrial respiratory chain complex assembly (GO:0033108)	2.68502951
76	dendrite morphogenesis (GO:0048813)	2.66013430
77	protein-cofactor linkage (GO:0018065)	2.65895650
78	response to leptin (GO:0044321)	2.65261375
79	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.64914766
80	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.64181420
81	sodium-independent organic anion transport (GO:0043252)	2.63761053
82	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.63553541
83	intraciliary transport (GO:0042073)	2.62834498
84	regulation of DNA methylation (GO:0044030)	2.61466068
85	startle response (GO:0001964)	2.60841863
86	potassium ion homeostasis (GO:0055075)	2.58474890
87	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	2.54481024
88	positive regulation of microtubule polymerization (GO:0031116)	2.52244426
89	forebrain neuron development (GO:0021884)	2.52053486
90	atrial cardiac muscle cell action potential (GO:0086014)	2.51909511
91	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.50508447
92	nephron tubule formation (GO:0072079)	2.49421434
93	regulation of synapse organization (GO:0050807)	2.48019057
94	positive regulation of neurological system process (GO:0031646)	2.47646580
95	neuron-neuron synaptic transmission (GO:0007270)	2.46894928
96	cell communication involved in cardiac conduction (GO:0086065)	2.46302477
97	purine nucleobase biosynthetic process (GO:0009113)	2.44526613
98	cerebral cortex radially oriented cell migration (GO:0021799)	2.44286226
99	axonogenesis (GO:0007409)	2.44111053
100	viral transcription (GO:0019083)	2.43894260

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.93946126
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.86984347
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.34921318
4	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.30057025
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.23904810
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.80878651
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46021966
8	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.45373654
9	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.37218315
10	FUS_26573619_Chip-Seq_HEK293_Human	2.37080575
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.29647182
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.24814259
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.21296142
14	AR_21572438_ChIP-Seq_LNCaP_Human	2.20127858
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12269431
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09859171
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.09857682
18	EWS_26573619_Chip-Seq_HEK293_Human	2.09725263
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93538165
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.92254797
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.91489152
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.87066555
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.82545632
24	P300_19829295_ChIP-Seq_ESCs_Human	1.82228978
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.78859958
26	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.78859958
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.74589913
28	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.73485348
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72225389
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.67536427
31	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65802286
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.63542898
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.62388238
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60964949
35	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.59346052
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56626700
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.56195520
38	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54641123
39	AR_25329375_ChIP-Seq_VCAP_Human	1.51691001
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.51143154
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50837190
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49320585
43	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.48424754
44	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.46033769
45	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.44904531
46	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44392305
47	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.41863386
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40804085
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.39632306
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.39273482
51	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38794921
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38764535
53	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36669037
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.34051290
55	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.33214209
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.32930064
57	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.31270512
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29436366
59	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.18490494
60	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17086837
61	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	1.12626346
62	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.12076886
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.11715269
64	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.11307307
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10872759
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.10481582
67	TCF4_23295773_ChIP-Seq_U87_Human	1.10146383
68	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.08313494
69	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.08313494
70	JUN_21703547_ChIP-Seq_K562_Human	1.07369554
71	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05763027
72	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.05568133
73	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.05023374
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.04707086
75	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.04308200
76	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.04190551
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03748573
78	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.01295369
79	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00672047
80	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00520370
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97175671
82	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96952649
83	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.96460305
84	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.96431109
85	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.96372916
86	CBP_20019798_ChIP-Seq_JUKART_Human	0.96372916
87	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.96160782
88	VDR_22108803_ChIP-Seq_LS180_Human	0.95922164
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95716102
90	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95713826
91	RXR_22108803_ChIP-Seq_LS180_Human	0.95196028
92	NFYB_21822215_ChIP-Seq_K562_Human	0.93897470
93	STAT3_23295773_ChIP-Seq_U87_Human	0.93461090
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93125274
95	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.92800393
96	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92426731
97	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.91966908
98	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.91455775
99	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.91433658
100	RUNX2_22187159_ChIP-Seq_PCA_Human	0.90486053

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.69785120
2	MP0006292_abnormal_olfactory_placode	3.58483972
3	MP0002736_abnormal_nociception_after	3.21194869
4	MP0004270_analgesia	2.98307226
5	MP0008058_abnormal_DNA_repair	2.91022658
6	MP0003880_abnormal_central_pattern	2.81805933
7	MP0000778_abnormal_nervous_system	2.72514324
8	MP0002234_abnormal_pharynx_morphology	2.62393680
9	MP0001968_abnormal_touch/_nociception	2.30820756
10	MP0005423_abnormal_somatic_nervous	2.27953996
11	MP0004859_abnormal_synaptic_plasticity	2.24075873
12	MP0008877_abnormal_DNA_methylation	2.12268872
13	MP0005394_taste/olfaction_phenotype	2.07125631
14	MP0005499_abnormal_olfactory_system	2.07125631
15	MP0005187_abnormal_penis_morphology	2.01081561
16	MP0002822_catalepsy	2.00661047
17	MP0006276_abnormal_autonomic_nervous	1.92077730
18	MP0004885_abnormal_endolymph	1.90744221
19	MP0008789_abnormal_olfactory_epithelium	1.86421811
20	MP0003635_abnormal_synaptic_transmissio	1.85952091
21	MP0002734_abnormal_mechanical_nocicepti	1.82583509
22	MP0004742_abnormal_vestibular_system	1.81477793
23	MP0002063_abnormal_learning/memory/cond	1.80096668
24	MP0001502_abnormal_circadian_rhythm	1.68544566
25	MP0006072_abnormal_retinal_apoptosis	1.67033302
26	MP0003787_abnormal_imprinting	1.66653094
27	MP0000049_abnormal_middle_ear	1.65026797
28	MP0002064_seizures	1.59207310
29	MP0002272_abnormal_nervous_system	1.55744185
30	MP0002233_abnormal_nose_morphology	1.51159251
31	MP0009745_abnormal_behavioral_response	1.49763578
32	MP0003868_abnormal_feces_composition	1.47691603
33	MP0005248_abnormal_Harderian_gland	1.45590287
34	MP0002751_abnormal_autonomic_nervous	1.44844991
35	MP0002882_abnormal_neuron_morphology	1.39779641
36	MP0002572_abnormal_emotion/affect_behav	1.38330137
37	MP0004043_abnormal_pH_regulation	1.38291148
38	MP0001529_abnormal_vocalization	1.37398648
39	MP0001486_abnormal_startle_reflex	1.33967904
40	MP0000631_abnormal_neuroendocrine_gland	1.33925326
41	MP0003195_calcinosis	1.32612438
42	MP0004811_abnormal_neuron_physiology	1.32436335
43	MP0005253_abnormal_eye_physiology	1.31975315
44	MP0000955_abnormal_spinal_cord	1.31503324
45	MP0004134_abnormal_chest_morphology	1.31410152
46	MP0004142_abnormal_muscle_tone	1.30889692
47	MP0000516_abnormal_urinary_system	1.30493319
48	MP0005367_renal/urinary_system_phenotyp	1.30493319
49	MP0002067_abnormal_sensory_capabilities	1.30280131
50	MP0003938_abnormal_ear_development	1.29068039
51	MP0002184_abnormal_innervation	1.23529302
52	MP0001986_abnormal_taste_sensitivity	1.21495298
53	MP0002102_abnormal_ear_morphology	1.21399498
54	MP0002638_abnormal_pupillary_reflex	1.21037531
55	MP0001905_abnormal_dopamine_level	1.20531468
56	MP0002752_abnormal_somatic_nervous	1.20301397
57	MP0002152_abnormal_brain_morphology	1.19636975
58	MP0003861_abnormal_nervous_system	1.17556070
59	MP0002557_abnormal_social/conspecific_i	1.17446015
60	MP0005551_abnormal_eye_electrophysiolog	1.13923685
61	MP0005386_behavior/neurological_phenoty	1.13850794
62	MP0004924_abnormal_behavior	1.13850794
63	MP0003755_abnormal_palate_morphology	1.13228005
64	MP0008569_lethality_at_weaning	1.11963178
65	MP0003385_abnormal_body_wall	1.05836002
66	MP0002735_abnormal_chemical_nociception	1.05373303
67	MP0003315_abnormal_perineum_morphology	1.04606539
68	MP0003121_genomic_imprinting	1.03424248
69	MP0001970_abnormal_pain_threshold	1.03257548
70	MP0003937_abnormal_limbs/digits/tail_de	1.01176111
71	MP0002733_abnormal_thermal_nociception	0.99913233
72	MP0008007_abnormal_cellular_replicative	0.99473005
73	MP0001188_hyperpigmentation	0.96876715
74	MP0002066_abnormal_motor_capabilities/c	0.95403872
75	MP0005174_abnormal_tail_pigmentation	0.94596744
76	MP0005646_abnormal_pituitary_gland	0.93683923
77	MP0005195_abnormal_posterior_eye	0.93470486
78	MP0010094_abnormal_chromosome_stability	0.90259352
79	MP0001963_abnormal_hearing_physiology	0.89679995
80	MP0003634_abnormal_glial_cell	0.88474490
81	MP0009046_muscle_twitch	0.87995581
82	MP0005391_vision/eye_phenotype	0.85588564
83	MP0001485_abnormal_pinna_reflex	0.83474619
84	MP0000026_abnormal_inner_ear	0.83172591
85	MP0002938_white_spotting	0.77823082
86	MP0002095_abnormal_skin_pigmentation	0.77589704
87	MP0000920_abnormal_myelination	0.77195323
88	MP0000647_abnormal_sebaceous_gland	0.75898075
89	MP0002229_neurodegeneration	0.75774573
90	MP0000566_synostosis	0.74162364
91	MP0003879_abnormal_hair_cell	0.74141553
92	MP0002081_perinatal_lethality	0.73423159
93	MP0003122_maternal_imprinting	0.72736349
94	MP0001324_abnormal_eye_pigmentation	0.72626054
95	MP0002082_postnatal_lethality	0.72103456
96	MP0010770_preweaning_lethality	0.72103456
97	MP0002069_abnormal_eating/drinking_beha	0.70446939
98	MP0001879_abnormal_lymphatic_vessel	0.70331793
99	MP0004782_abnormal_surfactant_physiolog	0.70001828
100	MP0003633_abnormal_nervous_system	0.69487000

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Colon cancer (HP:0003003)	4.50515247
2	Hypoglycemic seizures (HP:0002173)	4.07833463
3	Septo-optic dysplasia (HP:0100842)	3.99688899
4	11 pairs of ribs (HP:0000878)	3.92357176
5	Hyperventilation (HP:0002883)	3.87562753
6	Neoplasm of the oral cavity (HP:0100649)	3.79378903
7	Hypoglycemic coma (HP:0001325)	3.58401132
8	Reticulocytopenia (HP:0001896)	3.55451374
9	Abnormality of the septum pellucidum (HP:0007375)	3.46435457
10	Hepatoblastoma (HP:0002884)	3.45854958
11	Hyperinsulinemic hypoglycemia (HP:0000825)	3.31915999
12	Epileptic encephalopathy (HP:0200134)	3.20575210
13	Medulloblastoma (HP:0002885)	3.14331775
14	Intestinal atresia (HP:0011100)	3.06701223
15	Stomach cancer (HP:0012126)	3.06175137
16	Hypsarrhythmia (HP:0002521)	3.03526433
17	Drooling (HP:0002307)	2.93387457
18	EEG with generalized epileptiform discharges (HP:0011198)	2.92069291
19	Epileptiform EEG discharges (HP:0011182)	2.91507568
20	Absent septum pellucidum (HP:0001331)	2.89839908
21	Poor eye contact (HP:0000817)	2.88552266
22	Oligodactyly (hands) (HP:0001180)	2.83913531
23	Abnormality of the parietal bone (HP:0002696)	2.78618184
24	Abnormal social behavior (HP:0012433)	2.71025086
25	Impaired social interactions (HP:0000735)	2.71025086
26	Excessive salivation (HP:0003781)	2.68149634
27	Alacrima (HP:0000522)	2.66825202
28	Optic nerve hypoplasia (HP:0000609)	2.66644243
29	Focal motor seizures (HP:0011153)	2.65063431
30	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.61418468
31	Pancreatic cysts (HP:0001737)	2.55834139
32	Aplasia/hypoplasia of the uterus (HP:0008684)	2.54687444
33	Broad-based gait (HP:0002136)	2.52977768
34	Decreased lacrimation (HP:0000633)	2.46505291
35	Fibular aplasia (HP:0002990)	2.45261209
36	Pancreatic fibrosis (HP:0100732)	2.41890007
37	Abnormality of the metopic suture (HP:0005556)	2.40840809
38	Missing ribs (HP:0000921)	2.33225656
39	Abnormality of the labia minora (HP:0012880)	2.32727070
40	Volvulus (HP:0002580)	2.28422243
41	Protruding tongue (HP:0010808)	2.26486667
42	Abnormality of the astrocytes (HP:0100707)	2.25534974
43	Astrocytoma (HP:0009592)	2.25534974
44	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.23560047
45	Symptomatic seizures (HP:0011145)	2.15358147
46	Horseshoe kidney (HP:0000085)	2.12372917
47	Oligodactyly (HP:0012165)	2.09598388
48	True hermaphroditism (HP:0010459)	2.08869374
49	Prominent metopic ridge (HP:0005487)	2.06487010
50	Cerebral hypomyelination (HP:0006808)	2.06425822
51	Hemiparesis (HP:0001269)	2.02180100
52	Glioma (HP:0009733)	2.01722861
53	Large earlobe (HP:0009748)	1.98778058
54	Short phalanx of the thumb (HP:0009660)	1.97929231
55	Hypoplastic pelvis (HP:0008839)	1.96927069
56	Papillary thyroid carcinoma (HP:0002895)	1.96009649
57	Gait imbalance (HP:0002141)	1.94175554
58	Abnormal hair whorl (HP:0010721)	1.93635437
59	Atonic seizures (HP:0010819)	1.92888321
60	Gastrointestinal atresia (HP:0002589)	1.92571934
61	Nephrogenic diabetes insipidus (HP:0009806)	1.91772515
62	Abnormality of endocrine pancreas physiology (HP:0012093)	1.89234204
63	Abnormality of the pancreatic islet cells (HP:0006476)	1.89234204
64	Increased circulating renin level (HP:0000848)	1.87776660
65	Short thumb (HP:0009778)	1.83275726
66	Aqueductal stenosis (HP:0002410)	1.82799030
67	Hypoplasia of the radius (HP:0002984)	1.82450722
68	Pachygyria (HP:0001302)	1.81800512
69	Febrile seizures (HP:0002373)	1.79961273
70	Aplasia involving forearm bones (HP:0009822)	1.78203101
71	Absent forearm bone (HP:0003953)	1.78203101
72	Subacute progressive viral hepatitis (HP:0006572)	1.78188029
73	Growth hormone deficiency (HP:0000824)	1.76640575
74	Focal seizures (HP:0007359)	1.75941645
75	Hepatic necrosis (HP:0002605)	1.75794744
76	Neoplasm of the adrenal cortex (HP:0100641)	1.73789703
77	Renal hypoplasia (HP:0000089)	1.73208889
78	Genital tract atresia (HP:0001827)	1.72563383
79	Lissencephaly (HP:0001339)	1.72137326
80	Hemivertebrae (HP:0002937)	1.70165724
81	Hypoplasia of the uterus (HP:0000013)	1.69958417
82	Hepatocellular necrosis (HP:0001404)	1.69285135
83	Congenital malformation of the right heart (HP:0011723)	1.68241709
84	Double outlet right ventricle (HP:0001719)	1.68241709
85	Coarctation of aorta (HP:0001680)	1.67825071
86	Vaginal atresia (HP:0000148)	1.67280961
87	Partial duplication of thumb phalanx (HP:0009944)	1.66840542
88	Molar tooth sign on MRI (HP:0002419)	1.66829089
89	Abnormality of midbrain morphology (HP:0002418)	1.66829089
90	Fetal akinesia sequence (HP:0001989)	1.66786004
91	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.66754727
92	Limb dystonia (HP:0002451)	1.66401475
93	Thickened helices (HP:0000391)	1.66248874
94	Congenital primary aphakia (HP:0007707)	1.65963247
95	Chorioretinal coloboma (HP:0000567)	1.65807517
96	Scrotal hypoplasia (HP:0000046)	1.65472447
97	Medial flaring of the eyebrow (HP:0010747)	1.62758250
98	Esophageal atresia (HP:0002032)	1.62276860
99	Bicornuate uterus (HP:0000813)	1.61786267
100	Abnormality of the pons (HP:0007361)	1.61019485

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	5.24456404
2	MARK1	4.89736569
3	CCNB1	3.14569951
4	SRPK1	2.87660401
5	TAF1	2.62466245
6	MAP3K4	2.56562567
7	MAPK13	2.50498336
8	MAP2K7	2.34436124
9	CSNK1A1L	2.29991333
10	CSNK1G2	2.29373087
11	CSNK1G3	2.21199570
12	WNK3	2.09914865
13	CSNK1G1	2.09092314
14	NTRK3	2.07970170
15	MAP3K9	2.00350400
16	TNIK	1.97164591
17	NUAK1	1.91712412
18	NTRK2	1.87372536
19	STK16	1.85141139
20	KSR1	1.76760404
21	PINK1	1.65686935
22	EPHA4	1.65568545
23	RAF1	1.54559473
24	MKNK2	1.49446701
25	TRIM28	1.46573836
26	NTRK1	1.38882100
27	MST4	1.35658886
28	DYRK2	1.33709873
29	BCR	1.29695261
30	DMPK	1.24533846
31	EPHB1	1.17003764
32	GRK7	1.15870633
33	WNK1	1.14157858
34	TSSK6	1.11386023
35	DYRK1A	1.05805783
36	BRAF	0.97395806
37	PKN1	0.97005438
38	NME1	0.93621615
39	EIF2AK3	0.93602708
40	CAMK1D	0.92734869
41	MAP2K4	0.87800580
42	AKT3	0.87733205
43	GRK5	0.83546358
44	ARAF	0.82206840
45	PLK4	0.81287312
46	VRK1	0.78259186
47	VRK2	0.78032409
48	BMPR1B	0.76565171
49	PRKCG	0.73289497
50	ERBB4	0.72786045
51	UHMK1	0.72573847
52	FRK	0.71516509
53	MUSK	0.70963529
54	FLT3	0.70960342
55	CDK18	0.70909234
56	BRD4	0.70359836
57	CAMK1	0.70349234
58	CDK15	0.67704197
59	CDK14	0.66378600
60	PLK3	0.65248708
61	EPHB2	0.63945636
62	DAPK2	0.63460250
63	INSRR	0.62758235
64	CDK11A	0.62603899
65	MKNK1	0.62507561
66	CAMK1G	0.61317004
67	CDK5	0.59905498
68	PAK3	0.58476385
69	PASK	0.56112037
70	PHKG1	0.53749945
71	PHKG2	0.53749945
72	PLK2	0.51918732
73	CSNK1A1	0.51752712
74	PRKG1	0.51311742
75	CDC7	0.50880479
76	SGK2	0.50788675
77	CDK3	0.49875022
78	CSNK1E	0.49200114
79	KSR2	0.47917074
80	TYRO3	0.44564380
81	CSNK1D	0.42529269
82	ERBB2	0.40753746
83	PRKDC	0.40370900
84	OBSCN	0.40133021
85	SGK494	0.38802202
86	SGK223	0.38802202
87	MAP3K7	0.38502987
88	ROCK1	0.37987418
89	ATR	0.37457960
90	CAMK2A	0.36027295
91	PRKACA	0.35400796
92	SIK2	0.35025835
93	SIK3	0.34060924
94	PRKCE	0.33567617
95	ATM	0.33006576
96	FGFR2	0.31194164
97	ROCK2	0.30728812
98	CDK2	0.29829267
99	MINK1	0.29157724
100	MAPK14	0.28348747

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	3.84219746
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.43840394
3	Ribosome_Homo sapiens_hsa03010	2.86279095
4	Nicotine addiction_Homo sapiens_hsa05033	2.67073272
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10773811
6	Insulin secretion_Homo sapiens_hsa04911	2.10378776
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.03764161
8	RNA polymerase_Homo sapiens_hsa03020	1.82301878
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78268211
10	Basal transcription factors_Homo sapiens_hsa03022	1.75930397
11	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.68195340
12	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.64313710
13	Type II diabetes mellitus_Homo sapiens_hsa04930	1.60245721
14	Butanoate metabolism_Homo sapiens_hsa00650	1.57307159
15	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.57020946
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.56721716
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.52209755
18	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.50608700
19	Circadian rhythm_Homo sapiens_hsa04710	1.49486172
20	Cardiac muscle contraction_Homo sapiens_hsa04260	1.45771458
21	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.43023543
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.42123631
23	Circadian entrainment_Homo sapiens_hsa04713	1.41302355
24	Cocaine addiction_Homo sapiens_hsa05030	1.40587802
25	Protein export_Homo sapiens_hsa03060	1.38748953
26	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.36661555
27	Amphetamine addiction_Homo sapiens_hsa05031	1.35195288
28	Huntingtons disease_Homo sapiens_hsa05016	1.33989822
29	Parkinsons disease_Homo sapiens_hsa05012	1.33219629
30	Caffeine metabolism_Homo sapiens_hsa00232	1.32896475
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.31561439
32	Spliceosome_Homo sapiens_hsa03040	1.27659760
33	GABAergic synapse_Homo sapiens_hsa04727	1.24715760
34	Long-term depression_Homo sapiens_hsa04730	1.24137443
35	Regulation of autophagy_Homo sapiens_hsa04140	1.23272371
36	Long-term potentiation_Homo sapiens_hsa04720	1.23200139
37	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.22861518
38	RNA transport_Homo sapiens_hsa03013	1.22310229
39	RNA degradation_Homo sapiens_hsa03018	1.21826367
40	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.13448486
41	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.12116874
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.10143875
43	Axon guidance_Homo sapiens_hsa04360	1.08751897
44	Purine metabolism_Homo sapiens_hsa00230	1.07015993
45	Gastric acid secretion_Homo sapiens_hsa04971	1.03082599
46	Collecting duct acid secretion_Homo sapiens_hsa04966	1.01926647
47	mRNA surveillance pathway_Homo sapiens_hsa03015	0.96977429
48	cAMP signaling pathway_Homo sapiens_hsa04024	0.96464855
49	Alzheimers disease_Homo sapiens_hsa05010	0.96052765
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.94503587
51	Thyroid cancer_Homo sapiens_hsa05216	0.94093618
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.93880853
53	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.93574893
54	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.93091915
55	Homologous recombination_Homo sapiens_hsa03440	0.91782115
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.88586581
57	Taste transduction_Homo sapiens_hsa04742	0.86016961
58	Morphine addiction_Homo sapiens_hsa05032	0.84804867
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.84243617
60	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.84061888
61	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.80164539
62	Serotonergic synapse_Homo sapiens_hsa04726	0.78516232
63	Phototransduction_Homo sapiens_hsa04744	0.77723172
64	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.77509681
65	Endometrial cancer_Homo sapiens_hsa05213	0.77290950
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76079394
67	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.75949178
68	Salivary secretion_Homo sapiens_hsa04970	0.75105025
69	Fatty acid elongation_Homo sapiens_hsa00062	0.73473723
70	Mismatch repair_Homo sapiens_hsa03430	0.72257880
71	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.70547039
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.68500437
73	Cholinergic synapse_Homo sapiens_hsa04725	0.68262109
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.66977850
75	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.66934795
76	Renin secretion_Homo sapiens_hsa04924	0.63238943
77	Hippo signaling pathway_Homo sapiens_hsa04390	0.63061986
78	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.62208542
79	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.62197509
80	Gap junction_Homo sapiens_hsa04540	0.61605114
81	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.57920033
82	Glucagon signaling pathway_Homo sapiens_hsa04922	0.55895681
83	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.53682246
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.53363274
85	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.51593933
86	Oocyte meiosis_Homo sapiens_hsa04114	0.50972386
87	Melanogenesis_Homo sapiens_hsa04916	0.50527016
88	Selenocompound metabolism_Homo sapiens_hsa00450	0.49803753
89	Wnt signaling pathway_Homo sapiens_hsa04310	0.43954424
90	ErbB signaling pathway_Homo sapiens_hsa04012	0.42401350
91	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.41978995
92	Vibrio cholerae infection_Homo sapiens_hsa05110	0.40995639
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.40280946
94	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.38972071
95	Estrogen signaling pathway_Homo sapiens_hsa04915	0.38276004
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37387393
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.36876267
98	Olfactory transduction_Homo sapiens_hsa04740	0.36048952
99	Alcoholism_Homo sapiens_hsa05034	0.36030449
100	Prolactin signaling pathway_Homo sapiens_hsa04917	0.34616386

SEPHS1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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