SEPHS1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.03693732
2spinal cord motor neuron differentiation (GO:0021522)5.31448506
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.27439852
4behavioral response to nicotine (GO:0035095)4.93406694
5ATP synthesis coupled proton transport (GO:0015986)4.63167387
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.63167387
7cytidine metabolic process (GO:0046087)4.57694712
8cytidine catabolic process (GO:0006216)4.57694712
9cytidine deamination (GO:0009972)4.57694712
10ribosomal small subunit assembly (GO:0000028)4.46296681
11chaperone-mediated protein transport (GO:0072321)4.44702459
12pre-miRNA processing (GO:0031054)4.35860611
13maturation of SSU-rRNA (GO:0030490)4.33896163
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.26850956
15viral transcription (GO:0019083)4.14771571
16regulation of gene silencing by RNA (GO:0060966)4.07084546
17regulation of posttranscriptional gene silencing (GO:0060147)4.07084546
18regulation of gene silencing by miRNA (GO:0060964)4.07084546
19translational termination (GO:0006415)4.00913631
20cell differentiation in spinal cord (GO:0021515)3.97829792
21respiratory electron transport chain (GO:0022904)3.82367617
22regulation of cilium movement (GO:0003352)3.79861633
23GTP biosynthetic process (GO:0006183)3.78893983
24auditory behavior (GO:0031223)3.77499491
25electron transport chain (GO:0022900)3.77230182
26platelet dense granule organization (GO:0060155)3.73005593
27neuron fate commitment (GO:0048663)3.72729172
28adult walking behavior (GO:0007628)3.70931956
29pyrimidine ribonucleoside catabolic process (GO:0046133)3.66218830
30cotranslational protein targeting to membrane (GO:0006613)3.64572644
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60056659
32post-embryonic morphogenesis (GO:0009886)3.58222859
33protein targeting to ER (GO:0045047)3.55714069
34translational elongation (GO:0006414)3.53619622
35mechanosensory behavior (GO:0007638)3.51860542
36positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.51328809
37mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.51328809
38protein neddylation (GO:0045116)3.49742931
39negative regulation of cytosolic calcium ion concentration (GO:0051481)3.49645569
40ribosomal large subunit biogenesis (GO:0042273)3.45182846
41negative regulation of membrane potential (GO:0045837)3.44068367
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.41672024
43UTP biosynthetic process (GO:0006228)3.37430665
44regulation of dopamine secretion (GO:0014059)3.35274235
45response to pheromone (GO:0019236)3.34955882
46protein localization to endoplasmic reticulum (GO:0070972)3.34095721
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.28639273
48cochlea development (GO:0090102)3.25522478
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.25112562
50ribosomal small subunit biogenesis (GO:0042274)3.21750393
51UTP metabolic process (GO:0046051)3.21153829
52protein localization to kinetochore (GO:0034501)3.17381521
53water-soluble vitamin biosynthetic process (GO:0042364)3.17235323
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.16887538
55termination of RNA polymerase III transcription (GO:0006386)3.16887538
56cell wall macromolecule catabolic process (GO:0016998)3.15649082
57GPI anchor biosynthetic process (GO:0006506)3.14365496
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14359950
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12009360
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11017762
61presynaptic membrane assembly (GO:0097105)3.10468158
62histone mRNA metabolic process (GO:0008334)3.09766857
63cellular protein complex disassembly (GO:0043624)3.08373919
64primitive streak formation (GO:0090009)3.05757230
65ncRNA catabolic process (GO:0034661)3.05386333
66regulation of mitochondrial translation (GO:0070129)3.05339296
67purine nucleoside triphosphate biosynthetic process (GO:0009145)3.01938648
68DNA deamination (GO:0045006)2.99869855
69viral life cycle (GO:0019058)2.99351211
70postsynaptic membrane organization (GO:0001941)2.99219688
71positive regulation of filopodium assembly (GO:0051491)2.97915783
72purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.92370197
73positive regulation of protein homooligomerization (GO:0032464)2.89584907
74retinal cone cell development (GO:0046549)2.87205637
75negative regulation of ligase activity (GO:0051352)2.83997439
76negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.83997439
77GPI anchor metabolic process (GO:0006505)2.81368455
78presynaptic membrane organization (GO:0097090)2.81212355
79regulation of calcium ion-dependent exocytosis (GO:0017158)2.80134166
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79348283
81purine nucleotide salvage (GO:0032261)2.77659691
82nuclear-transcribed mRNA catabolic process (GO:0000956)2.72173753
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67130522
84intraciliary transport (GO:0042073)2.65984153
85ATP biosynthetic process (GO:0006754)2.65046896
86dicarboxylic acid catabolic process (GO:0043649)2.64113924
87positive regulation of mRNA processing (GO:0050685)2.63694043
88regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.61773129
89cell wall macromolecule metabolic process (GO:0044036)2.61668275
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61438795
91translational initiation (GO:0006413)2.58588699
927-methylguanosine mRNA capping (GO:0006370)2.57527984
93protein complex disassembly (GO:0043241)2.56458632
94mitochondrial respiratory chain complex I assembly (GO:0032981)2.55115853
95NADH dehydrogenase complex assembly (GO:0010257)2.55115853
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55115853
97RNA localization (GO:0006403)2.55077348
98mRNA catabolic process (GO:0006402)2.53355901
99metanephric mesenchyme development (GO:0072075)2.52771053
100hydrogen ion transmembrane transport (GO:1902600)2.52520988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.13983864
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.85684151
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.45510504
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.44700429
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36766129
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.86328972
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78797651
8VDR_22108803_ChIP-Seq_LS180_Human2.77949820
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.69832099
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63860605
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61591559
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45072975
13EWS_26573619_Chip-Seq_HEK293_Human2.40046899
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38044091
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37749790
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25770090
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.04381520
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94181662
19FUS_26573619_Chip-Seq_HEK293_Human1.88079923
20HTT_18923047_ChIP-ChIP_STHdh_Human1.84283443
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82711661
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.77084826
23SOX2_16153702_ChIP-ChIP_HESCs_Human1.74850872
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.71675476
25VDR_23849224_ChIP-Seq_CD4+_Human1.67312797
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66338301
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.66140723
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.66090337
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62485826
30SOX2_18555785_ChIP-Seq_MESCs_Mouse1.61409737
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.60080725
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59948015
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.59685553
34P300_19829295_ChIP-Seq_ESCs_Human1.57448360
35MYC_18940864_ChIP-ChIP_HL60_Human1.57274541
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56195074
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51055961
38NANOG_16153702_ChIP-ChIP_HESCs_Human1.50684562
39FOXP3_21729870_ChIP-Seq_TREG_Human1.47951089
40ELK1_19687146_ChIP-ChIP_HELA_Human1.47576433
41TP53_22573176_ChIP-Seq_HFKS_Human1.43280145
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40273467
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36274295
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.34709884
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32211756
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31229600
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31229600
48IGF1R_20145208_ChIP-Seq_DFB_Human1.29101361
49XRN2_22483619_ChIP-Seq_HELA_Human1.27055385
50ER_23166858_ChIP-Seq_MCF-7_Human1.26751933
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26006045
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24961097
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23913533
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21356216
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21139387
56TTF2_22483619_ChIP-Seq_HELA_Human1.20267248
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17661045
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16977899
59REST_21632747_ChIP-Seq_MESCs_Mouse1.16895799
60TAF15_26573619_Chip-Seq_HEK293_Human1.16245751
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.15209930
62FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15209930
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.11822290
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11134883
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09195224
66RNF2_27304074_Chip-Seq_NSC_Mouse1.09093806
67MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07277806
68MYC_19829295_ChIP-Seq_ESCs_Human1.05827005
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05319722
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.05077466
71KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04822560
72TAL1_26923725_Chip-Seq_HPCs_Mouse1.04402497
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.00619699
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00255833
75TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99274627
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97354160
77PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96778092
78FOXH1_21741376_ChIP-Seq_EPCs_Human0.96607716
79PRDM14_20953172_ChIP-Seq_ESCs_Human0.96121151
80MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.95877736
81SRF_21415370_ChIP-Seq_HL-1_Mouse0.95626236
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95619977
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94392734
84E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91587700
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91171548
86NCOR_22424771_ChIP-Seq_293T_Human0.91159905
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90054508
88RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89405614
89EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89405614
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88985219
91JARID2_20064375_ChIP-Seq_MESCs_Mouse0.86984809
92MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86758717
93ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86664427
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86435803
95WDR5_24793694_ChIP-Seq_LNCAP_Human0.86228571
96ZNF274_21170338_ChIP-Seq_K562_Hela0.85914339
97AR_20517297_ChIP-Seq_VCAP_Human0.85786118
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81446397
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80999393
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79750849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.07710157
2MP0006292_abnormal_olfactory_placode3.68751032
3MP0008877_abnormal_DNA_methylation3.51987806
4MP0003880_abnormal_central_pattern3.34969429
5MP0001984_abnormal_olfaction2.97834416
6MP0005423_abnormal_somatic_nervous2.86454449
7MP0000579_abnormal_nail_morphology2.71197857
8MP0002837_dystrophic_cardiac_calcinosis2.64772861
9MP0003787_abnormal_imprinting2.43519172
10MP0006072_abnormal_retinal_apoptosis2.32935493
11MP0002938_white_spotting2.32657682
12MP0008789_abnormal_olfactory_epithelium2.32071247
13MP0005499_abnormal_olfactory_system2.24960687
14MP0005394_taste/olfaction_phenotype2.24960687
15MP0005670_abnormal_white_adipose2.24939947
16MP0003136_yellow_coat_color2.23486642
17MP0000566_synostosis2.21557339
18MP0002638_abnormal_pupillary_reflex2.15864447
19MP0003890_abnormal_embryonic-extraembry2.09758643
20MP0008058_abnormal_DNA_repair1.87049915
21MP0005551_abnormal_eye_electrophysiolog1.77366396
22MP0001293_anophthalmia1.73265413
23MP0001529_abnormal_vocalization1.67477034
24MP0003567_abnormal_fetal_cardiomyocyte1.65660480
25MP0002653_abnormal_ependyma_morphology1.65618275
26MP0002909_abnormal_adrenal_gland1.61571673
27MP0002272_abnormal_nervous_system1.54426991
28MP0002736_abnormal_nociception_after1.51394903
29MP0002734_abnormal_mechanical_nocicepti1.49387448
30MP0002751_abnormal_autonomic_nervous1.47042450
31MP0005253_abnormal_eye_physiology1.43313554
32MP0003123_paternal_imprinting1.40701131
33MP0005377_hearing/vestibular/ear_phenot1.40281309
34MP0003878_abnormal_ear_physiology1.40281309
35MP0000631_abnormal_neuroendocrine_gland1.35357005
36MP0000372_irregular_coat_pigmentation1.32319410
37MP0009053_abnormal_anal_canal1.27185570
38MP0004957_abnormal_blastocyst_morpholog1.26582765
39MP0010094_abnormal_chromosome_stability1.25932762
40MP0001968_abnormal_touch/_nociception1.22644400
41MP0002163_abnormal_gland_morphology1.22247185
42MP0003011_delayed_dark_adaptation1.18597350
43MP0009384_cardiac_valve_regurgitation1.18304703
44MP0003693_abnormal_embryo_hatching1.12023103
45MP0004019_abnormal_vitamin_homeostasis1.08162313
46MP0001485_abnormal_pinna_reflex1.02830405
47MP0005391_vision/eye_phenotype1.02158723
48MP0002210_abnormal_sex_determination0.99865074
49MP0004133_heterotaxia0.99224701
50MP0000778_abnormal_nervous_system0.98952529
51MP0005646_abnormal_pituitary_gland0.98849292
52MP0004142_abnormal_muscle_tone0.98377032
53MP0005410_abnormal_fertilization0.98226281
54MP0005195_abnormal_posterior_eye0.97923848
55MP0010030_abnormal_orbit_morphology0.97868219
56MP0002557_abnormal_social/conspecific_i0.97142023
57MP0005197_abnormal_uvea_morphology0.96539531
58MP0003122_maternal_imprinting0.95982661
59MP0003121_genomic_imprinting0.94022674
60MP0005666_abnormal_adipose_tissue0.93864684
61MP0004185_abnormal_adipocyte_glucose0.92735639
62MP0001286_abnormal_eye_development0.92609687
63MP0001348_abnormal_lacrimal_gland0.91395485
64MP0008995_early_reproductive_senescence0.89978336
65MP0002132_abnormal_respiratory_system0.89665037
66MP0003718_maternal_effect0.87630085
67MP0000383_abnormal_hair_follicle0.87133148
68MP0008007_abnormal_cellular_replicative0.87078819
69MP0006276_abnormal_autonomic_nervous0.86721992
70MP0001765_abnormal_ion_homeostasis0.86692907
71MP0005636_abnormal_mineral_homeostasis0.86627389
72MP0003698_abnormal_male_reproductive0.85702662
73MP0009745_abnormal_behavioral_response0.85573601
74MP0003942_abnormal_urinary_system0.84548124
75MP0004147_increased_porphyrin_level0.84299728
76MP0001986_abnormal_taste_sensitivity0.82453592
77MP0005379_endocrine/exocrine_gland_phen0.81895365
78MP0003786_premature_aging0.80733659
79MP0010386_abnormal_urinary_bladder0.80462959
80MP0002064_seizures0.79592963
81MP0002876_abnormal_thyroid_physiology0.78539775
82MP0003646_muscle_fatigue0.78493707
83MP0002572_abnormal_emotion/affect_behav0.78374067
84MP0001501_abnormal_sleep_pattern0.76412838
85MP0001929_abnormal_gametogenesis0.75965345
86MP0001919_abnormal_reproductive_system0.75480465
87MP0001905_abnormal_dopamine_level0.72438910
88MP0005084_abnormal_gallbladder_morpholo0.71785573
89MP0002822_catalepsy0.71257490
90MP0001664_abnormal_digestion0.71051214
91MP0008770_decreased_survivor_rate0.70965472
92MP0000653_abnormal_sex_gland0.70633547
93MP0002752_abnormal_somatic_nervous0.69267736
94MP0001145_abnormal_male_reproductive0.68732747
95MP0002697_abnormal_eye_size0.68659597
96MP0001188_hyperpigmentation0.68177982
97MP0000538_abnormal_urinary_bladder0.68027960
98MP0003937_abnormal_limbs/digits/tail_de0.65083386
99MP0001970_abnormal_pain_threshold0.64027477
100MP0005389_reproductive_system_phenotype0.63145657

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)3.95874179
2Agitation (HP:0000713)3.80923839
3Acute necrotizing encephalopathy (HP:0006965)3.80242744
4Increased hepatocellular lipid droplets (HP:0006565)3.79684918
5Carpal bone hypoplasia (HP:0001498)3.51613166
6Lipid accumulation in hepatocytes (HP:0006561)3.40622190
7Mitochondrial inheritance (HP:0001427)3.38770606
8Hyperphosphatemia (HP:0002905)3.35916449
9Acute encephalopathy (HP:0006846)3.35234447
10Abnormal mitochondria in muscle tissue (HP:0008316)3.22897491
11Colon cancer (HP:0003003)3.18584323
12Abnormal drinking behavior (HP:0030082)3.18390400
13Polydipsia (HP:0001959)3.18390400
14Renal Fanconi syndrome (HP:0001994)3.10888889
15Progressive macrocephaly (HP:0004481)2.99090855
16Increased CSF lactate (HP:0002490)2.95950051
17Broad distal phalanx of finger (HP:0009836)2.89223337
18Intestinal atresia (HP:0011100)2.79558384
19Hyperventilation (HP:0002883)2.66288433
20Congenital, generalized hypertrichosis (HP:0004540)2.65516230
21Pancreatic cysts (HP:0001737)2.60765372
22Absent/shortened dynein arms (HP:0200106)2.60515996
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.60515996
24Rimmed vacuoles (HP:0003805)2.58135883
25Cerebral edema (HP:0002181)2.53985065
26Hyperglycinuria (HP:0003108)2.52300143
27Hemiplegia (HP:0002301)2.48112380
28Pendular nystagmus (HP:0012043)2.46399740
29Reticulocytopenia (HP:0001896)2.45009616
30Decreased circulating renin level (HP:0003351)2.42798209
31Nephronophthisis (HP:0000090)2.42569860
32Gastrointestinal atresia (HP:0002589)2.36945485
33Hypophosphatemic rickets (HP:0004912)2.36921055
34Restlessness (HP:0000711)2.32169475
353-Methylglutaconic aciduria (HP:0003535)2.30773399
36Abnormal number of erythroid precursors (HP:0012131)2.27130017
37Bilateral microphthalmos (HP:0007633)2.26419190
38Broad-based gait (HP:0002136)2.24330888
39Methylmalonic aciduria (HP:0012120)2.21762074
40Hepatocellular necrosis (HP:0001404)2.21247058
41Abnormality of urine glucose concentration (HP:0011016)2.17216890
42Glycosuria (HP:0003076)2.17216890
43Vaginal atresia (HP:0000148)2.17070365
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16541078
45Septo-optic dysplasia (HP:0100842)2.16526007
46Exertional dyspnea (HP:0002875)2.15222938
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13185528
48Genital tract atresia (HP:0001827)2.11136873
49Abnormality of the costochondral junction (HP:0000919)2.10800026
50Concave nail (HP:0001598)2.10285148
51Abnormality of renal resorption (HP:0011038)2.09398626
52Macrocytic anemia (HP:0001972)2.09128817
53Abnormal lung lobation (HP:0002101)2.08895485
54Abnormal ciliary motility (HP:0012262)2.08352558
55Pancreatic fibrosis (HP:0100732)2.07421203
56Polyuria (HP:0000103)2.06216272
57Abnormality of cells of the erythroid lineage (HP:0012130)2.05874394
58Medial flaring of the eyebrow (HP:0010747)2.04725926
59Abnormality of the labia minora (HP:0012880)2.04543101
60Gait imbalance (HP:0002141)2.03486845
61Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.03251784
62Oral leukoplakia (HP:0002745)2.03169118
63Delayed epiphyseal ossification (HP:0002663)2.02125869
64Hypoplastic pelvis (HP:0008839)1.99386406
65Cortical dysplasia (HP:0002539)1.96607205
66Chromsome breakage (HP:0040012)1.95659552
67Abnormal respiratory motile cilium physiology (HP:0012261)1.95502987
68Congenital primary aphakia (HP:0007707)1.94803562
69Aplasia/hypoplasia of the uterus (HP:0008684)1.94684300
70True hermaphroditism (HP:0010459)1.93344229
71Enlarged epiphyses (HP:0010580)1.92140699
72Abnormal respiratory epithelium morphology (HP:0012253)1.92004253
73Abnormal respiratory motile cilium morphology (HP:0005938)1.92004253
74Abnormal urine phosphate concentration (HP:0012599)1.91769094
75Respiratory difficulties (HP:0002880)1.91739916
76Abnormality of glycine metabolism (HP:0010895)1.90616748
77Abnormality of serine family amino acid metabolism (HP:0010894)1.90616748
78Sclerocornea (HP:0000647)1.90096141
79Abolished electroretinogram (ERG) (HP:0000550)1.87469228
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.87194213
81Nephrogenic diabetes insipidus (HP:0009806)1.86945587
82Meckel diverticulum (HP:0002245)1.86027103
83Myokymia (HP:0002411)1.85811409
84Aplasia/Hypoplasia involving the musculature (HP:0001460)1.85205538
85Thin bony cortex (HP:0002753)1.81710971
86Increased serum pyruvate (HP:0003542)1.81465068
872-3 toe syndactyly (HP:0004691)1.80854882
88Supernumerary spleens (HP:0009799)1.79183451
89Abnormality of the lacrimal duct (HP:0011481)1.79095755
90T lymphocytopenia (HP:0005403)1.78041765
91Bifid tongue (HP:0010297)1.77552227
92Ketoacidosis (HP:0001993)1.75328449
93Congenital hepatic fibrosis (HP:0002612)1.74300083
94Tubular atrophy (HP:0000092)1.73825533
95Abnormality of the nasolacrimal system (HP:0000614)1.73731472
96Facial cleft (HP:0002006)1.72520372
97Partial duplication of thumb phalanx (HP:0009944)1.71323151
98Hyperglycinemia (HP:0002154)1.71135706
99Irregular vertebral endplates (HP:0003301)1.70771966
100Esophageal atresia (HP:0002032)1.70325706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.65577297
2BUB12.90472733
3TTK2.86269804
4EPHA32.84407124
5SRPK12.75552872
6STK162.53627933
7TLK12.41873201
8BRSK12.41780617
9ZAK2.22402542
10WNK42.20941114
11VRK12.19027668
12TNIK2.05833751
13DYRK31.97417421
14ACVR1B1.82166040
15DYRK21.76363622
16TAF11.73496128
17ERBB41.64564406
18IRAK11.64206537
19TXK1.62072708
20VRK21.54626633
21PBK1.51103880
22MAPKAPK31.50725712
23BRSK21.48443658
24PLK31.47125018
25MAP4K21.45476593
26CAMKK11.43819237
27PRKCI1.43197530
28STK31.40523756
29PLK11.34035151
30STK41.33882003
31RPS6KA41.24274522
32STK241.23300152
33MKNK11.22809660
34MARK31.22766196
35MAP3K41.21831503
36PAK31.16619311
37PASK1.16087924
38CDC71.15695043
39PLK21.13743661
40MAP2K71.13016509
41CHEK21.12728157
42NUAK11.05305736
43WNK31.04754770
44KSR11.04515313
45EIF2AK31.03510184
46TESK20.97785208
47NEK10.96860220
48NLK0.95199084
49SGK2230.93780406
50SGK4940.93780406
51IRAK20.92991296
52FGFR10.88248722
53TYRO30.83818148
54PHKG20.82770124
55PHKG10.82770124
56CCNB10.82715042
57PIK3CA0.82617460
58ERBB30.81968014
59OXSR10.80003452
60MAPK130.73093389
61EPHA40.72520223
62FLT30.72114040
63MKNK20.72010528
64STK110.71734812
65STK390.69931874
66RPS6KA50.69847466
67PKN10.68623538
68PKN20.68507040
69RPS6KA20.68007387
70STK38L0.67536603
71FGFR20.67026623
72MAP3K110.65218061
73FRK0.63414377
74WEE10.62892074
75ERBB20.62840835
76ITK0.60540822
77AKT20.55832962
78NTRK20.54718313
79BRAF0.52445651
80CSNK2A20.52386178
81TRIM280.51213076
82PRKCG0.50863747
83CSNK2A10.48740387
84AURKB0.48369784
85INSRR0.48160733
86PRKCE0.45465710
87PRKACA0.43186449
88BMPR1B0.42970041
89ADRBK20.42518874
90IRAK40.42400463
91CSNK1E0.42193138
92FES0.39582542
93TNK20.38082929
94CSNK1A10.37848779
95PRKCQ0.37819520
96CDK150.37003108
97SGK20.36852633
98ADRBK10.36578526
99KDR0.35286675
100CDK180.33804048

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.49913961
2Ribosome_Homo sapiens_hsa030104.01239899
3Proteasome_Homo sapiens_hsa030503.78796865
4Parkinsons disease_Homo sapiens_hsa050123.73878454
5Protein export_Homo sapiens_hsa030603.31890499
6RNA polymerase_Homo sapiens_hsa030203.26962813
7Huntingtons disease_Homo sapiens_hsa050162.75775027
8Alzheimers disease_Homo sapiens_hsa050102.44801779
9Sulfur metabolism_Homo sapiens_hsa009202.41244277
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36211439
11Cardiac muscle contraction_Homo sapiens_hsa042602.05719919
12Fanconi anemia pathway_Homo sapiens_hsa034601.77237527
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75947080
14Spliceosome_Homo sapiens_hsa030401.70990726
15Non-homologous end-joining_Homo sapiens_hsa034501.70167067
16RNA degradation_Homo sapiens_hsa030181.69890000
17Regulation of autophagy_Homo sapiens_hsa041401.68399705
18DNA replication_Homo sapiens_hsa030301.67624789
19Homologous recombination_Homo sapiens_hsa034401.65693471
20Mismatch repair_Homo sapiens_hsa034301.56984939
21Nicotine addiction_Homo sapiens_hsa050331.53725216
22Fatty acid elongation_Homo sapiens_hsa000621.44072802
23Propanoate metabolism_Homo sapiens_hsa006401.42173798
24Nitrogen metabolism_Homo sapiens_hsa009101.40945751
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39045293
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38557899
27Pyrimidine metabolism_Homo sapiens_hsa002401.36673896
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32661871
29Base excision repair_Homo sapiens_hsa034101.27549584
30Basal transcription factors_Homo sapiens_hsa030221.26456852
31Purine metabolism_Homo sapiens_hsa002301.17416687
32Nucleotide excision repair_Homo sapiens_hsa034201.15136151
33Selenocompound metabolism_Homo sapiens_hsa004501.15097191
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11322853
35One carbon pool by folate_Homo sapiens_hsa006701.09997788
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.05888952
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04304840
38Systemic lupus erythematosus_Homo sapiens_hsa053221.01632184
39RNA transport_Homo sapiens_hsa030131.00006071
40Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99442730
41Collecting duct acid secretion_Homo sapiens_hsa049660.99386108
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.97657420
43Phototransduction_Homo sapiens_hsa047440.96532940
44Steroid biosynthesis_Homo sapiens_hsa001000.94757190
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92376734
46Alcoholism_Homo sapiens_hsa050340.91666235
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88484376
48Metabolic pathways_Homo sapiens_hsa011000.86770933
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.86274935
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86269255
51Caffeine metabolism_Homo sapiens_hsa002320.81542479
52Primary immunodeficiency_Homo sapiens_hsa053400.80413656
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80255351
54Folate biosynthesis_Homo sapiens_hsa007900.79534015
55Basal cell carcinoma_Homo sapiens_hsa052170.78979648
56Glutathione metabolism_Homo sapiens_hsa004800.76563422
57Hedgehog signaling pathway_Homo sapiens_hsa043400.75724455
58Cell cycle_Homo sapiens_hsa041100.74177036
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67468824
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67443419
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62929355
62Pyruvate metabolism_Homo sapiens_hsa006200.62566796
63Circadian entrainment_Homo sapiens_hsa047130.59496820
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58179001
65Peroxisome_Homo sapiens_hsa041460.53053877
66Retinol metabolism_Homo sapiens_hsa008300.52985123
67Olfactory transduction_Homo sapiens_hsa047400.49701322
68mRNA surveillance pathway_Homo sapiens_hsa030150.49639477
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47445421
70Galactose metabolism_Homo sapiens_hsa000520.45163878
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44522642
72Oocyte meiosis_Homo sapiens_hsa041140.43959006
73Morphine addiction_Homo sapiens_hsa050320.43488592
74Fatty acid biosynthesis_Homo sapiens_hsa000610.43052641
75Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41879540
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40754946
77Chemical carcinogenesis_Homo sapiens_hsa052040.38057606
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37712201
79Carbon metabolism_Homo sapiens_hsa012000.37622750
80Taste transduction_Homo sapiens_hsa047420.36540496
81Antigen processing and presentation_Homo sapiens_hsa046120.36250972
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35830411
83Butanoate metabolism_Homo sapiens_hsa006500.35355027
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32569409
85Cocaine addiction_Homo sapiens_hsa050300.32517588
86Biosynthesis of amino acids_Homo sapiens_hsa012300.32463875
87Hippo signaling pathway_Homo sapiens_hsa043900.28717812
88Epstein-Barr virus infection_Homo sapiens_hsa051690.28697064
89Glycerolipid metabolism_Homo sapiens_hsa005610.28185819
90Dopaminergic synapse_Homo sapiens_hsa047280.27783036
91Arginine and proline metabolism_Homo sapiens_hsa003300.27481113
92Amphetamine addiction_Homo sapiens_hsa050310.27440553
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26537248
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25023490
95Fat digestion and absorption_Homo sapiens_hsa049750.24230685
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22627398
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22526049
98Insulin secretion_Homo sapiens_hsa049110.22182117
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21976484
100GABAergic synapse_Homo sapiens_hsa047270.21770640

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