SEPHS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. Genes encoding selenocysteine contain a stem-loop secondary structure in their 3' UTR called a selenocysteine insertion sequence (SECIS) element. The protein encoded by this gene contains a selenocysteine residue in its predicted active site. There is a pseudogene for this gene on chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.41789176
2L-phenylalanine catabolic process (GO:0006559)7.41789176
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.16213301
4L-phenylalanine metabolic process (GO:0006558)7.16213301
5aromatic amino acid family catabolic process (GO:0009074)6.72521772
6indole-containing compound catabolic process (GO:0042436)6.10831595
7indolalkylamine catabolic process (GO:0046218)6.10831595
8tryptophan catabolic process (GO:0006569)6.10831595
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.05378733
10glyoxylate metabolic process (GO:0046487)5.93813209
11kynurenine metabolic process (GO:0070189)5.92142470
12urea cycle (GO:0000050)5.80288660
13urea metabolic process (GO:0019627)5.80288660
14bile acid biosynthetic process (GO:0006699)5.80042669
15tryptophan metabolic process (GO:0006568)5.75792767
16cysteine metabolic process (GO:0006534)5.71048384
17sulfur amino acid catabolic process (GO:0000098)5.48420639
18alpha-linolenic acid metabolic process (GO:0036109)5.42188760
19nitrogen cycle metabolic process (GO:0071941)5.34908556
20serine family amino acid catabolic process (GO:0009071)5.33680935
21negative regulation of fibrinolysis (GO:0051918)5.31461139
22high-density lipoprotein particle remodeling (GO:0034375)5.26540441
23epoxygenase P450 pathway (GO:0019373)5.11259378
24complement activation, alternative pathway (GO:0006957)5.10372225
25peptidyl-glutamic acid carboxylation (GO:0017187)5.07593840
26protein carboxylation (GO:0018214)5.07593840
27regulation of fibrinolysis (GO:0051917)5.05572170
28regulation of protein activation cascade (GO:2000257)5.05198665
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04030895
30lysine metabolic process (GO:0006553)4.96129741
31lysine catabolic process (GO:0006554)4.96129741
32homocysteine metabolic process (GO:0050667)4.95949535
33bile acid metabolic process (GO:0008206)4.94086345
34aromatic amino acid family metabolic process (GO:0009072)4.89829526
35glycine metabolic process (GO:0006544)4.79843960
36amino-acid betaine metabolic process (GO:0006577)4.79722157
37regulation of triglyceride catabolic process (GO:0010896)4.76898792
38regulation of complement activation (GO:0030449)4.71374875
39alpha-amino acid catabolic process (GO:1901606)4.69350037
40regulation of cholesterol esterification (GO:0010872)4.63314817
41reverse cholesterol transport (GO:0043691)4.60495513
42tyrosine metabolic process (GO:0006570)4.59954330
43protein-lipid complex remodeling (GO:0034368)4.57381462
44macromolecular complex remodeling (GO:0034367)4.57381462
45plasma lipoprotein particle remodeling (GO:0034369)4.57381462
46acylglycerol homeostasis (GO:0055090)4.47616993
47triglyceride homeostasis (GO:0070328)4.47616993
48* serine family amino acid metabolic process (GO:0009069)4.42194714
49negative regulation of cholesterol transport (GO:0032375)4.40866550
50negative regulation of sterol transport (GO:0032372)4.40866550
51imidazole-containing compound metabolic process (GO:0052803)4.40346674
52cellular amino acid catabolic process (GO:0009063)4.35710432
53phospholipid efflux (GO:0033700)4.34888267
54protein-lipid complex assembly (GO:0065005)4.33211212
55cellular ketone body metabolic process (GO:0046950)4.30946780
56fat-soluble vitamin biosynthetic process (GO:0042362)4.29337726
57indolalkylamine metabolic process (GO:0006586)4.29337089
58bile acid and bile salt transport (GO:0015721)4.25066012
59exogenous drug catabolic process (GO:0042738)4.24669107
60coenzyme catabolic process (GO:0009109)4.22998946
61plasma lipoprotein particle clearance (GO:0034381)4.22588076
62cellular biogenic amine catabolic process (GO:0042402)4.19699549
63amine catabolic process (GO:0009310)4.19699549
64cellular modified amino acid catabolic process (GO:0042219)4.19555812
65glutamate metabolic process (GO:0006536)4.18634260
66cellular glucuronidation (GO:0052695)4.18292393
67* serine family amino acid biosynthetic process (GO:0009070)4.08693295
68ethanol oxidation (GO:0006069)4.08585993
69benzene-containing compound metabolic process (GO:0042537)4.06663954
70aldehyde catabolic process (GO:0046185)4.05443584
71drug catabolic process (GO:0042737)4.01043198
72NADH metabolic process (GO:0006734)3.99614340
73cholesterol efflux (GO:0033344)3.96257174
74arginine metabolic process (GO:0006525)3.93308100
75omega-hydroxylase P450 pathway (GO:0097267)3.91317689
76plasma lipoprotein particle assembly (GO:0034377)3.89608041
77dicarboxylic acid biosynthetic process (GO:0043650)3.86879038
78low-density lipoprotein particle remodeling (GO:0034374)3.83160977
79carboxylic acid catabolic process (GO:0046395)3.81383587
80organic acid catabolic process (GO:0016054)3.81383587
81urate metabolic process (GO:0046415)3.75214748
82positive regulation of lipoprotein lipase activity (GO:0051006)3.74029567
83positive regulation of triglyceride lipase activity (GO:0061365)3.74029567
84fibrinolysis (GO:0042730)3.72619314
85acetyl-CoA metabolic process (GO:0006084)3.71796247
86ketone body metabolic process (GO:1902224)3.71104586
87uronic acid metabolic process (GO:0006063)3.70426350
88glucuronate metabolic process (GO:0019585)3.70426350
89cholesterol homeostasis (GO:0042632)3.68949950
90cofactor catabolic process (GO:0051187)3.68898202
91very-low-density lipoprotein particle assembly (GO:0034379)3.68713512
92phospholipid homeostasis (GO:0055091)3.67362843
93drug transmembrane transport (GO:0006855)3.66827692
94short-chain fatty acid metabolic process (GO:0046459)3.66353198
95response to nitrosative stress (GO:0051409)3.65273926
96blood coagulation, intrinsic pathway (GO:0007597)3.64705084
97aspartate family amino acid catabolic process (GO:0009068)3.64365045
98sterol homeostasis (GO:0055092)3.63648658
99proline metabolic process (GO:0006560)3.63586770
100regulation of bile acid biosynthetic process (GO:0070857)3.63390927
101regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.62012644
102regulation of cholesterol homeostasis (GO:2000188)3.60643752
103positive regulation of lipid catabolic process (GO:0050996)3.56825037
1042-oxoglutarate metabolic process (GO:0006103)3.56580711
105carnitine metabolic process (GO:0009437)3.56217907
106cytolysis (GO:0019835)3.54004178
107complement activation, classical pathway (GO:0006958)3.53954298
108nicotinamide nucleotide biosynthetic process (GO:0019359)3.52106287
109acute-phase response (GO:0006953)3.51404728
110plasma lipoprotein particle organization (GO:0071827)3.49725939
111fructose metabolic process (GO:0006000)3.45310149
112drug metabolic process (GO:0017144)3.44973733
113negative regulation of hemostasis (GO:1900047)3.40337881
114negative regulation of blood coagulation (GO:0030195)3.40337881
115proline biosynthetic process (GO:0006561)3.38856077
116intestinal absorption (GO:0050892)3.38708382
117protein-lipid complex subunit organization (GO:0071825)3.37500605
118angiotensin maturation (GO:0002003)3.36959145
119negative regulation of fatty acid biosynthetic process (GO:0045717)3.36003211
120intestinal cholesterol absorption (GO:0030299)3.35596415
121glycosphingolipid catabolic process (GO:0046479)3.29075368
122regulation of plasminogen activation (GO:0010755)3.27522879
123oxaloacetate metabolic process (GO:0006107)3.27447696
124ethanol metabolic process (GO:0006067)3.26620809
125protein activation cascade (GO:0072376)3.21902845
126positive regulation of fatty acid biosynthetic process (GO:0045723)3.13945890
127negative regulation of coagulation (GO:0050819)3.10468076
128complement activation (GO:0006956)3.10450815
129glycolipid catabolic process (GO:0019377)3.08930294
130glutamine family amino acid biosynthetic process (GO:0009084)3.02527861
131positive regulation of cellular amine metabolic process (GO:0033240)3.00174243
132oligosaccharide catabolic process (GO:0009313)2.95658349
133regulation of humoral immune response (GO:0002920)2.94975575
134polyketide metabolic process (GO:0030638)2.92920891
135doxorubicin metabolic process (GO:0044598)2.92920891
136daunorubicin metabolic process (GO:0044597)2.92920891
137negative regulation of wound healing (GO:0061045)2.89598681
138lipoprotein metabolic process (GO:0042157)2.85391772
139regulation of apoptotic cell clearance (GO:2000425)2.84598043
140COPI coating of Golgi vesicle (GO:0048205)2.82047929
141Golgi transport vesicle coating (GO:0048200)2.82047929
142hormone catabolic process (GO:0042447)2.78662343
143negative regulation of lipid transport (GO:0032369)2.77705217
144regulation of fatty acid biosynthetic process (GO:0042304)2.75592097
145phenylpropanoid metabolic process (GO:0009698)2.75458329
146regulation of lipoprotein particle clearance (GO:0010984)2.73847748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.13011821
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.06508003
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.80839012
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.14620814
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.17750222
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.00298236
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.92967089
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.19976064
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.62445928
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.27266900
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20942983
12VDR_21846776_ChIP-Seq_THP-1_Human2.20525594
13MYC_22102868_ChIP-Seq_BL_Human2.16764745
14* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5813834
15* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99060265
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91880542
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.79966092
18RACK7_27058665_Chip-Seq_MCF-7_Human1.70271032
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.55818771
20CLOCK_20551151_ChIP-Seq_293T_Human1.54690785
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54331884
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.47966770
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.46816820
24GATA1_22025678_ChIP-Seq_K562_Human1.45350834
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.41840535
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40020189
27* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37873094
28* FOXA2_19822575_ChIP-Seq_HepG2_Human1.33613438
29E2F7_22180533_ChIP-Seq_HELA_Human1.32437224
30VDR_24763502_ChIP-Seq_THP-1_Human1.32184289
31* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30376214
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30302714
33RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28591592
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27737622
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26051944
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25631793
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.24668460
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22617158
39* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22586296
40HTT_18923047_ChIP-ChIP_STHdh_Human1.21806663
41TCF7_22412390_ChIP-Seq_EML_Mouse1.20056621
42DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19216144
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17449003
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16940805
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.15502927
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12381344
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11998761
48PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10992457
49MAF_26560356_Chip-Seq_TH1_Human1.10314434
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10081912
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09253358
52* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09240854
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08994829
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08842265
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.08136226
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06229692
57* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04919704
58NCOR1_26117541_ChIP-Seq_K562_Human1.04270557
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03644139
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03265142
61* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02705226
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02686552
63* XRN2_22483619_ChIP-Seq_HELA_Human1.01465890
64TFEB_21752829_ChIP-Seq_HELA_Human1.01370899
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00984190
66ATF3_27146783_Chip-Seq_COLON_Human1.00501537
67PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99921863
68* P68_20966046_ChIP-Seq_HELA_Human0.99883901
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98873452
70MYC_19079543_ChIP-ChIP_MESCs_Mouse0.98281939
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97878893
72SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97848021
73KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97844738
74* ELF1_20517297_ChIP-Seq_JURKAT_Human0.97786226
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97690212
76RUNX1_22412390_ChIP-Seq_EML_Mouse0.97305794
77* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97221526
78CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96022531
79KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95311186
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95113312
81SA1_27219007_Chip-Seq_ERYTHROID_Human0.93950253
82SPI1_23547873_ChIP-Seq_NB4_Human0.93904406
83ZNF263_19887448_ChIP-Seq_K562_Human0.93091140
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93027544
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91785474
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91267967
87GATA4_25053715_ChIP-Seq_YYC3_Human0.91043272
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90793756
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87457904
90RARA_24833708_ChIP-Seq_LIVER_Mouse0.86231919
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85221658
92* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84698900
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.82547214
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.79397606
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.78537489
96AR_21909140_ChIP-Seq_LNCAP_Human0.76136306
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75898261
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.72925449
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.71786887
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70102595
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.69822609
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68742889
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68193941
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63690607
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.63623843
106* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63205577
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.61454133
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.61425143
109CEBPB_22108803_ChIP-Seq_LS180_Human0.60170888
110BRD4_27068464_Chip-Seq_AML-cells_Mouse0.58699241
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.58676761
112FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56747320
113RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56191440
114* GATA6_25053715_ChIP-Seq_YYC3_Human0.55865625
115AR_20517297_ChIP-Seq_VCAP_Human0.55043076
116ELF1_17652178_ChIP-ChIP_JURKAT_Human0.54107081
117LXR_22292898_ChIP-Seq_THP-1_Human0.54095784
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.53704717
119* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.52526874
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.52120714
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.50285502
122P53_21459846_ChIP-Seq_SAOS-2_Human0.48495242
123* BCOR_27268052_Chip-Seq_Bcells_Human0.48487090
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47594564
125CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46766619
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46549557
127EGR1_19032775_ChIP-ChIP_M12_Human0.45595089
128MYC_19915707_ChIP-ChIP_AK7_Human0.44458490
129STAT1_17558387_ChIP-Seq_HELA_Human0.44049739
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.43814994
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.43660376
132* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.43203930
133GATA2_22383799_ChIP-Seq_G1ME_Mouse0.43161005
134GATA1_22383799_ChIP-Seq_G1ME_Mouse0.43153311
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.42986672
136TAF2_19829295_ChIP-Seq_ESCs_Human0.42874326
137* ERG_20517297_ChIP-Seq_VCAP_Human0.42484018
138PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.42385848
139SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.42341044
140* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.42286981
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.42022544
142SRF_21415370_ChIP-Seq_HL-1_Mouse0.41361473
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.41226817
144SPI1_26923725_Chip-Seq_HPCs_Mouse0.41153610
145* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.40931584
146P300_27268052_Chip-Seq_Bcells_Human0.39695887
147CDX2_20551321_ChIP-Seq_CACO-2_Human0.39692495
148NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.39449003
149OCT4_18692474_ChIP-Seq_MEFs_Mouse0.39251044
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.38675338
151* BCL6_27268052_Chip-Seq_Bcells_Human0.38609466
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.38365029
153CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.38358983
154IRF1_19129219_ChIP-ChIP_H3396_Human0.37367045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.10027074
2MP0005360_urolithiasis7.59687227
3MP0005085_abnormal_gallbladder_physiolo6.18105684
4MP0005365_abnormal_bile_salt6.01169868
5MP0008875_abnormal_xenobiotic_pharmacok4.87849383
6MP0003806_abnormal_nucleotide_metabolis4.49577598
7MP0003252_abnormal_bile_duct3.74946344
8MP0010329_abnormal_lipoprotein_level3.43514106
9MP0009840_abnormal_foam_cell3.25829774
10MP0005083_abnormal_biliary_tract2.98368423
11MP0005332_abnormal_amino_acid2.88817622
12MP0003195_calcinosis2.74542217
13MP0001666_abnormal_nutrient_absorption2.65353498
14MP0003191_abnormal_cellular_cholesterol2.32262194
15MP0004019_abnormal_vitamin_homeostasis2.26296037
16MP0000609_abnormal_liver_physiology2.17979379
17MP0003303_peritoneal_inflammation2.06878697
18MP0002118_abnormal_lipid_homeostasis2.01700253
19MP0002138_abnormal_hepatobiliary_system2.01205586
20MP0005319_abnormal_enzyme/_coenzyme1.89010213
21MP0003868_abnormal_feces_composition1.82343875
22MP0001764_abnormal_homeostasis1.80068680
23MP0003172_abnormal_lysosome_physiology1.64516056
24MP0003186_abnormal_redox_activity1.55671280
25MP0005584_abnormal_enzyme/coenzyme_acti1.55380583
26MP0003183_abnormal_peptide_metabolism1.50248005
27MP0005451_abnormal_body_composition1.46909008
28MP0009697_abnormal_copulation1.45406059
29MP0009643_abnormal_urine_homeostasis1.42429474
30MP0009333_abnormal_splenocyte_physiolog1.38090471
31MP0010155_abnormal_intestine_physiology1.37881311
32MP0003300_gastrointestinal_ulcer1.37342397
33MP0009785_altered_susceptibility_to1.35549766
34MP0003656_abnormal_erythrocyte_physiolo1.28489693
35MP0000598_abnormal_liver_morphology1.26251967
36MP0003011_delayed_dark_adaptation1.24943956
37MP0005025_abnormal_response_to1.24161441
38MP0003705_abnormal_hypodermis_morpholog1.17448080
39MP0008260_abnormal_autophagy1.15996238
40MP0000858_altered_metastatic_potential1.14721619
41MP0005647_abnormal_sex_gland1.13412091
42MP0005636_abnormal_mineral_homeostasis1.08302638
43MP0002419_abnormal_innate_immunity1.07458932
44MP0001835_abnormal_antigen_presentation1.07249012
45MP0009763_increased_sensitivity_to1.03548240
46MP0006036_abnormal_mitochondrial_physio1.02652529
47MP0009764_decreased_sensitivity_to1.01381327
48MP0000685_abnormal_immune_system1.00570790
49MP0002254_reproductive_system_inflammat0.97948617
50MP0005408_hypopigmentation0.96772585
51MP0008469_abnormal_protein_level0.96526237
52MP0000604_amyloidosis0.93077422
53MP0001790_abnormal_immune_system0.92317819
54MP0005387_immune_system_phenotype0.92317819
55MP0005084_abnormal_gallbladder_morpholo0.91881071
56MP0005000_abnormal_immune_tolerance0.91797188
57MP0002148_abnormal_hypersensitivity_rea0.91279450
58MP0005670_abnormal_white_adipose0.89540699
59MP0005076_abnormal_cell_differentiation0.88375175
60MP0009642_abnormal_blood_homeostasis0.88294759
61MP0005220_abnormal_exocrine_pancreas0.88083784
62MP0001800_abnormal_humoral_immune0.85062512
63MP0004947_skin_inflammation0.85003215
64MP0005376_homeostasis/metabolism_phenot0.84225517
65MP0000490_abnormal_crypts_of0.84009380
66MP0009765_abnormal_xenobiotic_induced0.80971551
67MP0004185_abnormal_adipocyte_glucose0.80925719
68MP0003693_abnormal_embryo_hatching0.79921167
69MP0000678_abnormal_parathyroid_gland0.78069760
70MP0001873_stomach_inflammation0.77869278
71MP0002078_abnormal_glucose_homeostasis0.77304204
72MP0005266_abnormal_metabolism0.77293428
73MP0002166_altered_tumor_susceptibility0.76765274
74MP0005671_abnormal_response_to0.76578759
75MP0002876_abnormal_thyroid_physiology0.76356949
76MP0002452_abnormal_antigen_presenting0.74533110
77MP0002089_abnormal_postnatal_growth/wei0.74528122
78MP0003866_abnormal_defecation0.74137264
79MP0002723_abnormal_immune_serum0.73988185
80MP0005501_abnormal_skin_physiology0.73354701
81MP0002971_abnormal_brown_adipose0.73181898
82MP0005409_darkened_coat_color0.72221501
83MP0001533_abnormal_skeleton_physiology0.71447549
84MP0001915_intracranial_hemorrhage0.69800968
85MP0001756_abnormal_urination0.69580950
86MP0003718_maternal_effect0.68911236
87MP0006035_abnormal_mitochondrial_morpho0.68316239
88MP0002877_abnormal_melanocyte_morpholog0.66281112
89MP0001545_abnormal_hematopoietic_system0.66268482
90MP0005397_hematopoietic_system_phenotyp0.66268482
91MP0005334_abnormal_fat_pad0.66047314
92MP0010368_abnormal_lymphatic_system0.65975245
93MP0000477_abnormal_intestine_morphology0.65530406
94MP0004233_abnormal_muscle_weight0.64617084
95MP0001661_extended_life_span0.63941092
96MP0002998_abnormal_bone_remodeling0.63670936
97MP0001730_embryonic_growth_arrest0.63243556
98MP0005464_abnormal_platelet_physiology0.62201523
99MP0005535_abnormal_body_temperature0.61564062
100MP0002136_abnormal_kidney_physiology0.61103979
101MP0009053_abnormal_anal_canal0.60064289
102MP0003436_decreased_susceptibility_to0.59689790
103MP0004130_abnormal_muscle_cell0.57195088
104MP0005395_other_phenotype0.55772165
105MP0004782_abnormal_surfactant_physiolog0.52469630
106MP0002928_abnormal_bile_duct0.52405708
107MP0000639_abnormal_adrenal_gland0.51836718
108MP0005448_abnormal_energy_balance0.51366221
109MP0004264_abnormal_extraembryonic_tissu0.50144527
110MP0008873_increased_physiological_sensi0.48954077
111MP0003638_abnormal_response/metabolism_0.48907189
112MP0003724_increased_susceptibility_to0.48843171
113MP0005666_abnormal_adipose_tissue0.47451955
114MP0009672_abnormal_birth_weight0.43633346
115MP0001853_heart_inflammation0.41950718
116MP0001845_abnormal_inflammatory_respons0.41683122
117MP0003329_amyloid_beta_deposits0.41310063
118MP0002970_abnormal_white_adipose0.40826134
119MP0003953_abnormal_hormone_level0.39818767
120MP0009115_abnormal_fat_cell0.39537627
121MP0005058_abnormal_lysosome_morphology0.38347095
122MP0006082_CNS_inflammation0.35414265
123MP0005166_decreased_susceptibility_to0.34156136
124MP0003690_abnormal_glial_cell0.33508196
125MP0010234_abnormal_vibrissa_follicle0.33258483
126MP0004043_abnormal_pH_regulation0.32914589
127MP0002796_impaired_skin_barrier0.32227391
128MP0003075_altered_response_to0.32196385
129MP0002132_abnormal_respiratory_system0.31933437
130MP0008874_decreased_physiological_sensi0.31866115
131MP0002135_abnormal_kidney_morphology0.31481786
132MP0008872_abnormal_physiological_respon0.30817203
133MP0001765_abnormal_ion_homeostasis0.30664146
134MP0004381_abnormal_hair_follicle0.29794602
135MP0001881_abnormal_mammary_gland0.29031181
136MP0001243_abnormal_dermal_layer0.28250219
137MP0002168_other_aberrant_phenotype0.27662916
138MP0000249_abnormal_blood_vessel0.26603986
139MP0005075_abnormal_melanosome_morpholog0.26340516
140MP0003453_abnormal_keratinocyte_physiol0.24729816
141MP0003699_abnormal_female_reproductive0.24196758
142MP0005023_abnormal_wound_healing0.24031821

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.18027473
2Intrahepatic cholestasis (HP:0001406)7.06344831
3Deep venous thrombosis (HP:0002625)6.80627960
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.58776243
5Hypobetalipoproteinemia (HP:0003563)6.26625419
6Prolonged partial thromboplastin time (HP:0003645)6.04681197
7Xanthomatosis (HP:0000991)6.02823468
8Hyperlipoproteinemia (HP:0010980)5.09864309
9Complement deficiency (HP:0004431)5.00277199
10Hyperammonemia (HP:0001987)4.73465697
11Hypolipoproteinemia (HP:0010981)4.62663453
12Joint hemorrhage (HP:0005261)4.52229617
13Hyperglycinemia (HP:0002154)4.51591775
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.42699474
15Ketosis (HP:0001946)4.34609658
16Hyperglycinuria (HP:0003108)4.32420332
17Epidermoid cyst (HP:0200040)4.31448483
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.29867594
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22273597
20Abnormality of the common coagulation pathway (HP:0010990)4.21394645
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.20454641
22Abnormality of methionine metabolism (HP:0010901)4.20323924
23Abnormality of glycine metabolism (HP:0010895)4.14568622
24Abnormality of serine family amino acid metabolism (HP:0010894)4.14568622
25Fat malabsorption (HP:0002630)4.11176408
26Abnormality of pyrimidine metabolism (HP:0004353)4.09244119
27Hypoglycemic coma (HP:0001325)3.98783798
28Hypoalphalipoproteinemia (HP:0003233)3.93988181
29Abnormality of complement system (HP:0005339)3.72479991
30Abnormality of the intrinsic pathway (HP:0010989)3.63046025
31Abnormality of fatty-acid metabolism (HP:0004359)3.51455430
32Conjugated hyperbilirubinemia (HP:0002908)3.49812650
33Hypercholesterolemia (HP:0003124)3.48031011
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44896810
35Hyperbilirubinemia (HP:0002904)3.35194983
36Abnormality of nucleobase metabolism (HP:0010932)3.34443038
37Hemorrhage of the eye (HP:0011885)3.26494098
38Abnormality of serum amino acid levels (HP:0003112)3.19257648
39Ketoacidosis (HP:0001993)3.16783924
40Delayed CNS myelination (HP:0002188)3.15926626
41Steatorrhea (HP:0002570)3.08622883
42Purpura (HP:0000979)2.99260863
43Hepatocellular carcinoma (HP:0001402)2.98969791
44Abnormality of purine metabolism (HP:0004352)2.97042497
45Gout (HP:0001997)2.93982906
46Metabolic acidosis (HP:0001942)2.86119766
47Abnormality of glycolipid metabolism (HP:0010969)2.84401052
48Abnormality of liposaccharide metabolism (HP:0010968)2.84401052
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.84401052
50Myocardial infarction (HP:0001658)2.81123175
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.81031554
52Dicarboxylic aciduria (HP:0003215)2.81031554
53Spontaneous abortion (HP:0005268)2.78729600
54Lethargy (HP:0001254)2.77192164
55Hypochromic microcytic anemia (HP:0004840)2.69049923
56Acanthocytosis (HP:0001927)2.62878355
57Spastic diplegia (HP:0001264)2.59200802
58Vascular calcification (HP:0004934)2.57189293
59Systemic lupus erythematosus (HP:0002725)2.56829682
60Skin nodule (HP:0200036)2.53944729
61Cerebral edema (HP:0002181)2.49568797
62Malnutrition (HP:0004395)2.47685378
63Hypoglycemic seizures (HP:0002173)2.46225319
64Nephritis (HP:0000123)2.43614166
65Irritability (HP:0000737)2.43431515
66Vacuolated lymphocytes (HP:0001922)2.43297136
67Recurrent gram-negative bacterial infections (HP:0005420)2.42813614
68Increased serum ferritin (HP:0003281)2.40739984
69Generalized aminoaciduria (HP:0002909)2.39964195
70Neonatal onset (HP:0003623)2.35407036
71Late onset (HP:0003584)2.33648992
72Abnormal gallbladder morphology (HP:0012437)2.31758892
73Increased cerebral lipofuscin (HP:0011813)2.31418308
74Pancreatitis (HP:0001733)2.27819690
75Dysostosis multiplex (HP:0000943)2.27760943
76Cholelithiasis (HP:0001081)2.27556558
77Glomerulonephritis (HP:0000099)2.25873935
78Mucopolysacchariduria (HP:0008155)2.25232640
79Urinary glycosaminoglycan excretion (HP:0003541)2.25232640
80Abnormal gallbladder physiology (HP:0012438)2.24778909
81Cholecystitis (HP:0001082)2.24778909
82Cardiovascular calcification (HP:0011915)2.24274934
83Hypophosphatemia (HP:0002148)2.22033779
84Abnormality of the Achilles tendon (HP:0005109)2.19160716
85Vomiting (HP:0002013)2.18226650
86Abnormality of polysaccharide metabolism (HP:0011012)2.16701058
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16701058
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16701058
89Esophageal varix (HP:0002040)2.15470146
90Elevated alkaline phosphatase (HP:0003155)2.15077248
91Reduced antithrombin III activity (HP:0001976)2.14854694
92Mitral stenosis (HP:0001718)2.14184582
93Proximal tubulopathy (HP:0000114)2.14092357
94Brushfield spots (HP:0001088)2.13982031
95Ragged-red muscle fibers (HP:0003200)2.11093849
96Abnormality of alkaline phosphatase activity (HP:0004379)2.10373166
97Abnormal tarsal ossification (HP:0008369)2.10307993
98Thrombophlebitis (HP:0004418)2.09969486
99Increased neuronal autofluorescent lipopigment (HP:0002074)2.09775528
100Sensorimotor neuropathy (HP:0007141)2.08333826
101Flat acetabular roof (HP:0003180)2.07475077
102Hyperuricemia (HP:0002149)2.06219129
103Increased purine levels (HP:0004368)2.06219129
104Gingival bleeding (HP:0000225)2.06139329
105Enlarged kidneys (HP:0000105)2.05940838
106Poikilocytosis (HP:0004447)2.05592759
107Menorrhagia (HP:0000132)2.04969269
108Opisthotonus (HP:0002179)2.04619336
109Abnormality of macrophages (HP:0004311)2.03556242
110Hydroxyprolinuria (HP:0003080)2.02633513
111Abnormality of proline metabolism (HP:0010907)2.02633513
112Abnormality of transition element cation homeostasis (HP:0011030)2.02420191
113Hyperinsulinemic hypoglycemia (HP:0000825)2.02026882
114Eczematoid dermatitis (HP:0000976)2.01476581
115Amyloidosis (HP:0011034)2.00943333
116Alkalosis (HP:0001948)2.00543118
117Abnormality of iron homeostasis (HP:0011031)1.98211207
118Vertebral compression fractures (HP:0002953)1.98186433
119Widely patent fontanelles and sutures (HP:0004492)1.97009815
120Abnormal cartilage morphology (HP:0002763)1.96988947
121Abnormal enzyme/coenzyme activity (HP:0012379)1.95122180
122Nausea (HP:0002018)1.91931864
123Abnormality of the gallbladder (HP:0005264)1.91548537
124Elevated hepatic transaminases (HP:0002910)1.90822706
125Renal cortical cysts (HP:0000803)1.89100106
126Glycosuria (HP:0003076)1.89065113
127Abnormality of urine glucose concentration (HP:0011016)1.89065113
128Abnormality of glycolysis (HP:0004366)1.88396823
129Rickets (HP:0002748)1.87992065
130Loss of speech (HP:0002371)1.87625498
131Abdominal distention (HP:0003270)1.85692279
132Increased serum pyruvate (HP:0003542)1.84305916
133Bone pain (HP:0002653)1.78929661
134Seborrheic dermatitis (HP:0001051)1.76356163
135Thoracic kyphosis (HP:0002942)1.75543831
136Progressive neurologic deterioration (HP:0002344)1.74893050
137Abnormality of the lumbar spine (HP:0100712)1.74280319
138Thin bony cortex (HP:0002753)1.73675117
139J-shaped sella turcica (HP:0002680)1.70787289
140Joint swelling (HP:0001386)1.70506395
141Polycythemia (HP:0001901)1.67503402
142Impaired platelet aggregation (HP:0003540)1.67494917
143Abnormal platelet function (HP:0011869)1.67494917
144Pulmonary embolism (HP:0002204)1.67458947
145Abnormality of vitamin metabolism (HP:0100508)1.67322257
146Polygenic inheritance (HP:0010982)1.67141193
147Achilles tendon contracture (HP:0001771)1.66364828
148Abnormality of carpal bone ossification (HP:0006257)1.64497306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.68661940
2ERN14.22886953
3FGFR43.94888864
4SIK13.71262700
5SMG13.08506621
6PRPF4B2.88337256
7TAOK32.84182239
8ERBB42.80650873
9PKN22.55868565
10FLT32.51558491
11ICK2.45171188
12CDK122.32138625
13INSRR2.31907555
14SCYL22.24745751
15EEF2K2.17135081
16MAPK111.93199155
17RIPK41.93149094
18MST1R1.76491201
19TRIB31.71389391
20TYK21.68234279
21FRK1.64744567
22GRK61.63533221
23MAP2K41.61721164
24PIK3CG1.56301861
25KDR1.52479227
26ABL21.49460602
27MAP3K101.45956946
28LATS11.44977349
29NEK91.39299918
30MAP3K11.39052516
31MAP2K31.33452216
32PIM21.33249170
33STK38L1.29856289
34PTK61.24573251
35PDK41.24088336
36PDK31.24088336
37MATK1.19374215
38JAK21.19236612
39NEK11.14763382
40MAP3K111.14250728
41TAOK11.10960957
42MAP3K131.07483703
43KSR21.06673690
44CDK61.06490867
45PINK11.04400289
46PRKAA21.03427580
47TBK11.03337572
48RPS6KB21.03111430
49ARAF1.02570907
50IRAK41.01524078
51TESK21.00190246
52EIF2AK30.99439800
53MAP3K140.98966028
54IRAK30.98227577
55TESK10.97938458
56MAP3K30.96697064
57CDK40.94959213
58MAPK40.93674580
59DYRK1B0.92758431
60PAK40.92428250
61SIK30.85793662
62EIF2AK10.82527661
63PRKG20.82445988
64BLK0.80341973
65CDK70.78133516
66JAK30.77654894
67LRRK20.77425744
68PIK3CA0.77140803
69MAP3K70.75953150
70JAK10.72436363
71MAP2K60.72191432
72PRKAA10.71101162
73CDC42BPA0.68080469
74CSK0.67395399
75ERBB20.67254619
76CSF1R0.66225115
77PRKCZ0.64826147
78DDR20.64578425
79DAPK20.63481409
80MAP3K20.63029930
81LMTK20.62016230
82MAPK150.61811456
83GSK3A0.60981676
84PRKACG0.59265836
85ACVR1B0.57852688
86PIM10.56017776
87MAP3K50.55850846
88MET0.55566284
89ALK0.55472553
90EPHA20.54948343
91CDK90.54500069
92MAP3K60.53863387
93FGFR20.53648728
94IKBKE0.53348409
95PDK20.52898785
96PDGFRA0.51493476
97SGK30.49022778
98TGFBR20.49007646
99IKBKB0.48355496
100MAP4K10.48349841
101TAOK20.47536134
102WEE10.47214955
103SIK20.46525514
104NME20.45720538
105MAPKAPK30.45217995
106WNK30.44395876
107RPS6KB10.43874050
108RET0.43376072
109KIT0.43372448
110FGR0.42327435
111RIPK10.42079368
112EPHB10.41643132
113AKT20.41497935
114CAMK1D0.41161463
115IRAK20.40619804
116MAP3K80.40345773
117ZAP700.40243396
118MAPK120.39681721
119STK40.38537544
120MAPKAPK20.37727279
121MTOR0.37527522
122PBK0.36905622
123CLK10.36409462
124BRAF0.36384443
125MAP2K20.35377110
126FGFR30.35246840
127PTK20.34517728
128BTK0.33951579
129STK100.33789179
130LYN0.33368591
131SGK20.33169286
132STK160.32839676
133CAMK2G0.32431042
134TTK0.30446473
135PDPK10.30319858
136RPS6KC10.29768215
137RPS6KL10.29768215
138LATS20.29328926
139STK30.29113954
140CHUK0.25707081
141NEK20.25454114
142TIE10.25398132
143IGF1R0.24782162
144CSNK1G10.24543822
145PDK10.24048570
146MAP2K10.23217187

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30750095
2Nitrogen metabolism_Homo sapiens_hsa009103.44669694
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39539909
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29013676
5Arginine biosynthesis_Homo sapiens_hsa002202.99545718
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73979259
7Tryptophan metabolism_Homo sapiens_hsa003802.64962896
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62045907
9Complement and coagulation cascades_Homo sapiens_hsa046102.53288300
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.51619044
11Fatty acid degradation_Homo sapiens_hsa000712.51052898
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45764447
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.35329695
14Peroxisome_Homo sapiens_hsa041462.11475004
15Butanoate metabolism_Homo sapiens_hsa006502.09504801
16Propanoate metabolism_Homo sapiens_hsa006402.04225096
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02514810
18Histidine metabolism_Homo sapiens_hsa003401.86479884
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.85490836
20Chemical carcinogenesis_Homo sapiens_hsa052041.83986314
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83094866
22PPAR signaling pathway_Homo sapiens_hsa033201.80546470
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.79067131
24Fatty acid metabolism_Homo sapiens_hsa012121.75847286
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73911336
26beta-Alanine metabolism_Homo sapiens_hsa004101.73698963
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70379778
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69153114
29Caffeine metabolism_Homo sapiens_hsa002321.67303764
30Retinol metabolism_Homo sapiens_hsa008301.61713401
31Staphylococcus aureus infection_Homo sapiens_hsa051501.61216235
32Pyruvate metabolism_Homo sapiens_hsa006201.52103884
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50283280
34Phenylalanine metabolism_Homo sapiens_hsa003601.49953188
35* Selenocompound metabolism_Homo sapiens_hsa004501.49425472
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.46083333
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44188264
38Folate biosynthesis_Homo sapiens_hsa007901.40067156
39Biosynthesis of amino acids_Homo sapiens_hsa012301.39405005
40Bile secretion_Homo sapiens_hsa049761.38233854
41Tyrosine metabolism_Homo sapiens_hsa003501.32782135
42Carbon metabolism_Homo sapiens_hsa012001.31801934
43Starch and sucrose metabolism_Homo sapiens_hsa005001.30947436
44Sulfur metabolism_Homo sapiens_hsa009201.30615892
45Fat digestion and absorption_Homo sapiens_hsa049751.29586827
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.29197884
47Fatty acid elongation_Homo sapiens_hsa000621.21950478
48ABC transporters_Homo sapiens_hsa020101.11634955
49One carbon pool by folate_Homo sapiens_hsa006701.08938519
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.08379767
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04336863
52Sulfur relay system_Homo sapiens_hsa041221.04324485
53Steroid biosynthesis_Homo sapiens_hsa001001.03886946
54Arginine and proline metabolism_Homo sapiens_hsa003301.01640812
55Vitamin B6 metabolism_Homo sapiens_hsa007500.99107472
56Vitamin digestion and absorption_Homo sapiens_hsa049770.97724790
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91147496
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88313779
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88165920
60Lysosome_Homo sapiens_hsa041420.87615917
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87329274
62Pentose phosphate pathway_Homo sapiens_hsa000300.83156795
63Lysine degradation_Homo sapiens_hsa003100.83061616
64Glutathione metabolism_Homo sapiens_hsa004800.82449563
65Glycerolipid metabolism_Homo sapiens_hsa005610.76864185
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75514943
67Pertussis_Homo sapiens_hsa051330.68868024
68Mineral absorption_Homo sapiens_hsa049780.56725908
69Leishmaniasis_Homo sapiens_hsa051400.54889672
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53070917
71* Metabolic pathways_Homo sapiens_hsa011000.51228014
72Allograft rejection_Homo sapiens_hsa053300.47421325
73Fatty acid biosynthesis_Homo sapiens_hsa000610.47046871
74Acute myeloid leukemia_Homo sapiens_hsa052210.47010523
75Asthma_Homo sapiens_hsa053100.46454613
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.46221109
77Sphingolipid metabolism_Homo sapiens_hsa006000.43896436
78Influenza A_Homo sapiens_hsa051640.41450022
79B cell receptor signaling pathway_Homo sapiens_hsa046620.40991046
80Fructose and mannose metabolism_Homo sapiens_hsa000510.40021609
81Galactose metabolism_Homo sapiens_hsa000520.38098549
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.38064336
83Herpes simplex infection_Homo sapiens_hsa051680.34072543
84Antigen processing and presentation_Homo sapiens_hsa046120.34053689
85Tuberculosis_Homo sapiens_hsa051520.32358308
86Autoimmune thyroid disease_Homo sapiens_hsa053200.31862740
87Osteoclast differentiation_Homo sapiens_hsa043800.29613663
88N-Glycan biosynthesis_Homo sapiens_hsa005100.29278392
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26796374
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.26680006
91Prion diseases_Homo sapiens_hsa050200.25094769
92Graft-versus-host disease_Homo sapiens_hsa053320.24522233
93Linoleic acid metabolism_Homo sapiens_hsa005910.22122317
94Vibrio cholerae infection_Homo sapiens_hsa051100.21246647
95TNF signaling pathway_Homo sapiens_hsa046680.20420782
96Apoptosis_Homo sapiens_hsa042100.20341635
97Insulin resistance_Homo sapiens_hsa049310.19234269
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.17329148
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.13971910
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09566116
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09522636
102Glucagon signaling pathway_Homo sapiens_hsa049220.08394354
103Systemic lupus erythematosus_Homo sapiens_hsa053220.02702716
104AMPK signaling pathway_Homo sapiens_hsa041520.01727131
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2313554
106Bladder cancer_Homo sapiens_hsa05219-0.2248048
107Other glycan degradation_Homo sapiens_hsa00511-0.2143627
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2142641
109Legionellosis_Homo sapiens_hsa05134-0.2046583
110Hepatitis C_Homo sapiens_hsa05160-0.1935436
111Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1784396
112Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1762704
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1749217
114Regulation of autophagy_Homo sapiens_hsa04140-0.1504030
115Insulin signaling pathway_Homo sapiens_hsa04910-0.1294522
116Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1132467
117Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1079386
118Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1045961
119Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0796375
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0658014
121Pyrimidine metabolism_Homo sapiens_hsa00240-0.0498735
122Renin-angiotensin system_Homo sapiens_hsa04614-0.0489433
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0303972

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