

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | chondrocyte proliferation (GO:0035988) | 4.59497782 |
| 2 | collagen fibril organization (GO:0030199) | 4.40589392 |
| 3 | endodermal cell differentiation (GO:0035987) | 4.29590030 |
| 4 | protein heterotrimerization (GO:0070208) | 4.23861085 |
| 5 | axon extension involved in axon guidance (GO:0048846) | 4.09773302 |
| 6 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 4.09773302 |
| 7 | basement membrane organization (GO:0071711) | 3.95902204 |
| 8 | bone trabecula formation (GO:0060346) | 3.95687685 |
| 9 | blood vessel maturation (GO:0001955) | 3.83550471 |
| 10 | barbed-end actin filament capping (GO:0051016) | 3.71630348 |
| 11 | collagen metabolic process (GO:0032963) | 3.63993913 |
| 12 | collagen catabolic process (GO:0030574) | 3.59147359 |
| 13 | cell adhesion mediated by integrin (GO:0033627) | 3.55199951 |
| 14 | negative regulation of fatty acid transport (GO:2000192) | 3.49112615 |
| 15 | wound healing, spreading of epidermal cells (GO:0035313) | 3.40418151 |
| 16 | multicellular organismal macromolecule metabolic process (GO:0044259) | 3.37953455 |
| 17 | glomerular filtration (GO:0003094) | 3.33645204 |
| 18 | paraxial mesoderm development (GO:0048339) | 3.33340823 |
| 19 | sequestering of extracellular ligand from receptor (GO:0035581) | 3.33203199 |
| 20 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 3.32045185 |
| 21 | renal filtration (GO:0097205) | 3.31151034 |
| 22 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 3.25997054 |
| 23 | cell-substrate junction assembly (GO:0007044) | 3.25458157 |
| 24 | multicellular organismal catabolic process (GO:0044243) | 3.24226813 |
| 25 | protein localization to endosome (GO:0036010) | 3.21381877 |
| 26 | focal adhesion assembly (GO:0048041) | 3.19133947 |
| 27 | cell-substrate adherens junction assembly (GO:0007045) | 3.19133947 |
| 28 | regulation of early endosome to late endosome transport (GO:2000641) | 3.16015490 |
| 29 | endothelial cell chemotaxis (GO:0035767) | 3.15667768 |
| 30 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 3.15362034 |
| 31 | extracellular matrix disassembly (GO:0022617) | 3.11498077 |
| 32 | multicellular organismal metabolic process (GO:0044236) | 3.10042794 |
| 33 | endocardial cushion development (GO:0003197) | 3.08238481 |
| 34 | endothelial cell morphogenesis (GO:0001886) | 3.07584544 |
| 35 | plasma membrane repair (GO:0001778) | 3.07223132 |
| 36 | vascular endothelial growth factor receptor signaling pathway (GO:0048010) | 3.07094526 |
| 37 | semaphorin-plexin signaling pathway (GO:0071526) | 3.05320573 |
| 38 | cell migration involved in heart development (GO:0060973) | 3.02989279 |
| 39 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 3.00164503 |
| 40 | negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948) | 2.99950114 |
| 41 | stress fiber assembly (GO:0043149) | 2.99710488 |
| 42 | regulation of establishment of planar polarity (GO:0090175) | 2.99383640 |
| 43 | convergent extension (GO:0060026) | 2.98510534 |
| 44 | substrate-dependent cell migration (GO:0006929) | 2.97956720 |
| 45 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.96044246 |
| 46 | endothelial tube morphogenesis (GO:0061154) | 2.94438929 |
| 47 | morphogenesis of an endothelium (GO:0003159) | 2.94438929 |
| 48 | positive regulation of epithelial to mesenchymal transition (GO:0010718) | 2.94309119 |
| 49 | wound healing, spreading of cells (GO:0044319) | 2.92826992 |
| 50 | craniofacial suture morphogenesis (GO:0097094) | 2.90608556 |
| 51 | dermatan sulfate biosynthetic process (GO:0030208) | 2.90536068 |
| 52 | outer ear morphogenesis (GO:0042473) | 2.89302833 |
| 53 | skin morphogenesis (GO:0043589) | 2.89049218 |
| 54 | Golgi transport vesicle coating (GO:0048200) | 2.88713530 |
| 55 | COPI coating of Golgi vesicle (GO:0048205) | 2.88713530 |
| 56 | positive regulation of receptor recycling (GO:0001921) | 2.87258756 |
| 57 | negative regulation of chondrocyte differentiation (GO:0032331) | 2.86298180 |
| 58 | mesodermal cell differentiation (GO:0048333) | 2.86240507 |
| 59 | cell-cell junction maintenance (GO:0045217) | 2.84152029 |
| 60 | positive regulation of blood vessel endothelial cell migration (GO:0043536) | 2.82680159 |
| 61 | peptidyl-proline hydroxylation (GO:0019511) | 2.82020538 |
| 62 | cochlea morphogenesis (GO:0090103) | 2.80169063 |
| 63 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 2.79959474 |
| 64 | cell migration involved in sprouting angiogenesis (GO:0002042) | 2.79158245 |
| 65 | cortical actin cytoskeleton organization (GO:0030866) | 2.79143137 |
| 66 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 2.78263918 |
| 67 | regulation of extracellular matrix disassembly (GO:0010715) | 2.77483178 |
| 68 | positive regulation of endothelial cell differentiation (GO:0045603) | 2.76159780 |
| 69 | positive regulation of cartilage development (GO:0061036) | 2.73882649 |
| 70 | response to fluid shear stress (GO:0034405) | 2.73718973 |
| 71 | apoptotic cell clearance (GO:0043277) | 2.73209986 |
| 72 | mesenchymal-epithelial cell signaling (GO:0060638) | 2.72703160 |
| 73 | lymph vessel development (GO:0001945) | 2.72669791 |
| 74 | lymphangiogenesis (GO:0001946) | 2.71254296 |
| 75 | vascular endothelial growth factor signaling pathway (GO:0038084) | 2.70334943 |
| 76 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.70142524 |
| 77 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 2.70137569 |
| 78 | dermatan sulfate metabolic process (GO:0030205) | 2.69624988 |
| 79 | virion attachment to host cell (GO:0019062) | 2.68342422 |
| 80 | adhesion of symbiont to host cell (GO:0044650) | 2.68342422 |
| 81 | hippo signaling (GO:0035329) | 2.66775485 |
| 82 | adhesion of symbiont to host (GO:0044406) | 2.64188384 |
| 83 | substrate adhesion-dependent cell spreading (GO:0034446) | 2.62521252 |
| 84 | negative regulation of smooth muscle cell migration (GO:0014912) | 2.60713832 |
| 85 | cellular response to vascular endothelial growth factor stimulus (GO:0035924) | 2.60522747 |
| 86 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.59956954 |
| 87 | branching involved in salivary gland morphogenesis (GO:0060445) | 2.59754638 |
| 88 | mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337) | 2.59426579 |
| 89 | non-canonical Wnt signaling pathway (GO:0035567) | 2.59261876 |
| 90 | blood vessel endothelial cell migration (GO:0043534) | 2.58986547 |
| 91 | regulation of endothelial cell differentiation (GO:0045601) | 2.58805764 |
| 92 | cellular response to vitamin D (GO:0071305) | 2.58339141 |
| 93 | glomerular basement membrane development (GO:0032836) | 2.57775179 |
| 94 | cellular response to vitamin (GO:0071295) | 2.57338871 |
| 95 | response to laminar fluid shear stress (GO:0034616) | 2.57225780 |
| 96 | polarized epithelial cell differentiation (GO:0030859) | 2.55535193 |
| 97 | glial cell migration (GO:0008347) | 2.54476242 |
| 98 | venous blood vessel morphogenesis (GO:0048845) | 2.54007192 |
| 99 | extracellular matrix assembly (GO:0085029) | 2.53099710 |
| 100 | camera-type eye morphogenesis (GO:0048593) | 2.52722012 |
| 101 | embryonic cranial skeleton morphogenesis (GO:0048701) | 2.52508702 |
| 102 | regulation of cartilage development (GO:0061035) | 2.52132776 |
| 103 | mannose metabolic process (GO:0006013) | 2.51472322 |
| 104 | negative regulation of catenin import into nucleus (GO:0035414) | 2.51264026 |
| 105 | cell proliferation involved in metanephros development (GO:0072203) | 2.51131718 |
| 106 | epithelial cell-cell adhesion (GO:0090136) | 2.50327442 |
| 107 | adherens junction assembly (GO:0034333) | 2.49342583 |
| 108 | negative regulation of focal adhesion assembly (GO:0051895) | 2.46211361 |
| 109 | negative regulation of cell junction assembly (GO:1901889) | 2.46211361 |
| 110 | negative regulation of adherens junction organization (GO:1903392) | 2.46211361 |
| 111 | negative regulation of cartilage development (GO:0061037) | 2.45416499 |
| 112 | insulin-like growth factor receptor signaling pathway (GO:0048009) | 2.44825835 |
| 113 | endothelial cell proliferation (GO:0001935) | 2.44824080 |
| 114 | hemidesmosome assembly (GO:0031581) | 2.44732093 |
| 115 | cortical cytoskeleton organization (GO:0030865) | 2.44483642 |
| 116 | extracellular matrix organization (GO:0030198) | 2.44464424 |
| 117 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.43905729 |
| 118 | chondroitin sulfate biosynthetic process (GO:0030206) | 2.43306661 |
| 119 | extracellular fibril organization (GO:0043206) | 2.43026548 |
| 120 | extracellular structure organization (GO:0043062) | 2.42715163 |
| 121 | keratan sulfate catabolic process (GO:0042340) | 2.41698675 |
| 122 | apoptotic process involved in morphogenesis (GO:0060561) | 2.41109689 |
| 123 | G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199 | 2.40589440 |
| 124 | chondrocyte development (GO:0002063) | 2.40050227 |
| 125 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr | 2.40024181 |
| 126 | regulation of heart morphogenesis (GO:2000826) | 2.39807984 |
| 127 | protein localization to cell surface (GO:0034394) | 2.39568710 |
| 128 | positive regulation of chondrocyte differentiation (GO:0032332) | 2.39232061 |
| 129 | fibril organization (GO:0097435) | 2.38567320 |
| 130 | hyaluronan catabolic process (GO:0030214) | 2.37885892 |
| 131 | regulation of chondrocyte differentiation (GO:0032330) | 2.37642453 |
| 132 | cell-matrix adhesion (GO:0007160) | 2.36097051 |
| 133 | kidney mesenchyme development (GO:0072074) | 2.36086775 |
| 134 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.35928210 |
| 135 | protein hydroxylation (GO:0018126) | 2.35602094 |
| 136 | atrioventricular valve morphogenesis (GO:0003181) | 2.35473931 |
| 137 | positive regulation of osteoblast proliferation (GO:0033690) | 2.34312425 |
| 138 | protein retention in ER lumen (GO:0006621) | 2.34284674 |
| 139 | eye morphogenesis (GO:0048592) | 2.33799065 |
| 140 | negative regulation of cell size (GO:0045792) | 2.33519340 |
| 141 | cell-substrate adhesion (GO:0031589) | 2.33508773 |
| 142 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.32713977 |
| 143 | establishment or maintenance of bipolar cell polarity (GO:0061245) | 2.32369942 |
| 144 | establishment or maintenance of apical/basal cell polarity (GO:0035088) | 2.32369942 |
| 145 | regulation of SMAD protein import into nucleus (GO:0060390) | 2.32183479 |
| 146 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.32027749 |
| 147 | protein targeting to plasma membrane (GO:0072661) | 2.31492606 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 4.72079152 |
| 2 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 3.63811964 |
| 3 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.45422713 |
| 4 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 3.21203437 |
| 5 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.14557959 |
| 6 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.95278608 |
| 7 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 2.87849268 |
| 8 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 2.69997687 |
| 9 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 2.54162830 |
| 10 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 2.49450748 |
| 11 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 2.47180467 |
| 12 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 2.33786662 |
| 13 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 2.27916478 |
| 14 | CLOCK_20551151_ChIP-Seq_293T_Human | 2.22616138 |
| 15 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 2.20069236 |
| 16 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.82751338 |
| 17 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.81609114 |
| 18 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.80957357 |
| 19 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.79326467 |
| 20 | * P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.76669639 |
| 21 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.74187270 |
| 22 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.73266584 |
| 23 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.72307042 |
| 24 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.71172185 |
| 25 | * KDM2B_26808549_Chip-Seq_K562_Human | 1.69737268 |
| 26 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.69347873 |
| 27 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.65329669 |
| 28 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.62557546 |
| 29 | * LXR_22292898_ChIP-Seq_THP-1_Human | 1.61053480 |
| 30 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.59904727 |
| 31 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.58582576 |
| 32 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.56610081 |
| 33 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.56569863 |
| 34 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.56569863 |
| 35 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.54823393 |
| 36 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.53860062 |
| 37 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.53131405 |
| 38 | CJUN_26792858_Chip-Seq_BT549_Human | 1.52920874 |
| 39 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.52050053 |
| 40 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.51811812 |
| 41 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.51077955 |
| 42 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.49089216 |
| 43 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.47976847 |
| 44 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.47603768 |
| 45 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.46606986 |
| 46 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.46040213 |
| 47 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.44374903 |
| 48 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 1.43241100 |
| 49 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.42338401 |
| 50 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.41574864 |
| 51 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.41371707 |
| 52 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.40311885 |
| 53 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.40111071 |
| 54 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 1.38884807 |
| 55 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.38766885 |
| 56 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.37830511 |
| 57 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.37665617 |
| 58 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.37665617 |
| 59 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.37557431 |
| 60 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.36611599 |
| 61 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.36175798 |
| 62 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.35526269 |
| 63 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.35500511 |
| 64 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.34766890 |
| 65 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 1.33254995 |
| 66 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.32958307 |
| 67 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.32288505 |
| 68 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.32248618 |
| 69 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.29025220 |
| 70 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.29025220 |
| 71 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.29025220 |
| 72 | MYC_22102868_ChIP-Seq_BL_Human | 1.29006549 |
| 73 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.27855163 |
| 74 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.27454664 |
| 75 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.25385980 |
| 76 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.24919565 |
| 77 | * TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.23376266 |
| 78 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.21859982 |
| 79 | SPI1_23127762_ChIP-Seq_K562_Human | 1.21461673 |
| 80 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.20394649 |
| 81 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.19315283 |
| 82 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.18720195 |
| 83 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.17594595 |
| 84 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.17554638 |
| 85 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.17458877 |
| 86 | * CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.17123217 |
| 87 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.16585605 |
| 88 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.15976581 |
| 89 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.15561815 |
| 90 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.15299230 |
| 91 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.14980168 |
| 92 | TP53_22127205_ChIP-Seq_IMR90_Human | 1.13796270 |
| 93 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.13635422 |
| 94 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.13284271 |
| 95 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.12562856 |
| 96 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.12412357 |
| 97 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.11886140 |
| 98 | ATF3_27146783_Chip-Seq_COLON_Human | 1.11844634 |
| 99 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.11565295 |
| 100 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.11500054 |
| 101 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.11080532 |
| 102 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 1.10974490 |
| 103 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.10514358 |
| 104 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.10514358 |
| 105 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.10324142 |
| 106 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 1.09927632 |
| 107 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.09182010 |
| 108 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.08665196 |
| 109 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.08591897 |
| 110 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.08448706 |
| 111 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.07571608 |
| 112 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.06796047 |
| 113 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.06792445 |
| 114 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.06736550 |
| 115 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.06593006 |
| 116 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.06267449 |
| 117 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.05936813 |
| 118 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.05910385 |
| 119 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.05463147 |
| 120 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.05282628 |
| 121 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.05242939 |
| 122 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.04925471 |
| 123 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.04925471 |
| 124 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.04901641 |
| 125 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.04041582 |
| 126 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.02198476 |
| 127 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.00018249 |
| 128 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.99478246 |
| 129 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.96412192 |
| 130 | P68_20966046_ChIP-Seq_HELA_Human | 0.93991395 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008438_abnormal_cutaneous_collagen | 6.00314057 |
| 2 | MP0005503_abnormal_tendon_morphology | 3.82847937 |
| 3 | MP0003279_aneurysm | 3.61325102 |
| 4 | MP0003705_abnormal_hypodermis_morpholog | 3.27785914 |
| 5 | MP0004272_abnormal_basement_membrane | 3.21514545 |
| 6 | MP0005275_abnormal_skin_tensile | 3.12831634 |
| 7 | MP0001958_emphysema | 3.05867216 |
| 8 | MP0010368_abnormal_lymphatic_system | 3.00579653 |
| 9 | MP0005623_abnormal_meninges_morphology | 2.86444784 |
| 10 | MP0001849_ear_inflammation | 2.48785919 |
| 11 | MP0009278_abnormal_bone_marrow | 2.42195380 |
| 12 | MP0006054_spinal_hemorrhage | 2.37354021 |
| 13 | MP0005409_darkened_coat_color | 2.35068236 |
| 14 | MP0003566_abnormal_cell_adhesion | 2.11774415 |
| 15 | MP0010030_abnormal_orbit_morphology | 2.00420727 |
| 16 | MP0005257_abnormal_intraocular_pressure | 1.94241055 |
| 17 | MP0001879_abnormal_lymphatic_vessel | 1.91990927 |
| 18 | MP0003385_abnormal_body_wall | 1.85046628 |
| 19 | MP0005508_abnormal_skeleton_morphology | 1.76781617 |
| 20 | MP0000534_abnormal_ureter_morphology | 1.75675357 |
| 21 | MP0003122_maternal_imprinting | 1.73878532 |
| 22 | MP0000733_abnormal_muscle_development | 1.70602867 |
| 23 | MP0009384_cardiac_valve_regurgitation | 1.70407254 |
| 24 | MP0000767_abnormal_smooth_muscle | 1.67788929 |
| 25 | MP0009250_abnormal_appendicular_skeleto | 1.61318962 |
| 26 | MP0000516_abnormal_urinary_system | 1.57816684 |
| 27 | MP0005367_renal/urinary_system_phenotyp | 1.57816684 |
| 28 | MP0005023_abnormal_wound_healing | 1.49704393 |
| 29 | MP0003091_abnormal_cell_migration | 1.42613169 |
| 30 | MP0002933_joint_inflammation | 1.41366659 |
| 31 | MP0004233_abnormal_muscle_weight | 1.41235817 |
| 32 | MP0002089_abnormal_postnatal_growth/wei | 1.39276216 |
| 33 | MP0005171_absent_coat_pigmentation | 1.35932472 |
| 34 | MP0001299_abnormal_eye_distance/ | 1.35248626 |
| 35 | MP0003942_abnormal_urinary_system | 1.32306053 |
| 36 | MP0000428_abnormal_craniofacial_morphol | 1.30368715 |
| 37 | MP0002295_abnormal_pulmonary_circulatio | 1.30042307 |
| 38 | MP0004808_abnormal_hematopoietic_stem | 1.29428334 |
| 39 | MP0004084_abnormal_cardiac_muscle | 1.27197027 |
| 40 | MP0002282_abnormal_trachea_morphology | 1.26628525 |
| 41 | MP0003115_abnormal_respiratory_system | 1.24081628 |
| 42 | MP0005390_skeleton_phenotype | 1.23927785 |
| 43 | MP0002932_abnormal_joint_morphology | 1.23364836 |
| 44 | MP0009840_abnormal_foam_cell | 1.21484180 |
| 45 | MP0000537_abnormal_urethra_morphology | 1.21250386 |
| 46 | MP0002896_abnormal_bone_mineralization | 1.20817069 |
| 47 | MP0005167_abnormal_blood-brain_barrier | 1.19992491 |
| 48 | MP0003329_amyloid_beta_deposits | 1.19536035 |
| 49 | MP0003300_gastrointestinal_ulcer | 1.18868792 |
| 50 | MP0002060_abnormal_skin_morphology | 1.18341432 |
| 51 | MP0000751_myopathy | 1.17137359 |
| 52 | MP0010352_gastrointestinal_tract_polyps | 1.16197164 |
| 53 | MP0000049_abnormal_middle_ear | 1.15080121 |
| 54 | MP0002108_abnormal_muscle_morphology | 1.15053413 |
| 55 | MP0000762_abnormal_tongue_morphology | 1.14936708 |
| 56 | MP0004134_abnormal_chest_morphology | 1.11853334 |
| 57 | MP0002877_abnormal_melanocyte_morpholog | 1.11224566 |
| 58 | MP0000678_abnormal_parathyroid_gland | 1.10677656 |
| 59 | MP0003828_pulmonary_edema | 1.10452956 |
| 60 | MP0002128_abnormal_blood_circulation | 1.10414182 |
| 61 | MP0001533_abnormal_skeleton_physiology | 1.10363465 |
| 62 | MP0009053_abnormal_anal_canal | 1.09224441 |
| 63 | MP0001614_abnormal_blood_vessel | 1.06612372 |
| 64 | MP0002925_abnormal_cardiovascular_devel | 1.05540771 |
| 65 | MP0005076_abnormal_cell_differentiation | 1.04986218 |
| 66 | MP0002113_abnormal_skeleton_development | 1.04675360 |
| 67 | MP0000163_abnormal_cartilage_morphology | 1.03142054 |
| 68 | MP0003935_abnormal_craniofacial_develop | 1.02332739 |
| 69 | MP0004858_abnormal_nervous_system | 1.02045003 |
| 70 | MP0002254_reproductive_system_inflammat | 1.01887326 |
| 71 | MP0003303_peritoneal_inflammation | 1.01294220 |
| 72 | MP0002115_abnormal_skeleton_extremities | 1.01246736 |
| 73 | MP0002234_abnormal_pharynx_morphology | 0.97162840 |
| 74 | MP0003634_abnormal_glial_cell | 0.96891471 |
| 75 | MP0000343_altered_response_to | 0.95120399 |
| 76 | MP0003172_abnormal_lysosome_physiology | 0.94721073 |
| 77 | MP0000749_muscle_degeneration | 0.94385048 |
| 78 | MP0003453_abnormal_keratinocyte_physiol | 0.94345982 |
| 79 | MP0002998_abnormal_bone_remodeling | 0.93835782 |
| 80 | MP0000462_abnormal_digestive_system | 0.93138210 |
| 81 | MP0009780_abnormal_chondrocyte_physiolo | 0.91346949 |
| 82 | MP0003567_abnormal_fetal_cardiomyocyte | 0.90937803 |
| 83 | MP0000465_gastrointestinal_hemorrhage | 0.89882629 |
| 84 | MP0003283_abnormal_digestive_organ | 0.89184274 |
| 85 | MP0000013_abnormal_adipose_tissue | 0.87115644 |
| 86 | MP0005197_abnormal_uvea_morphology | 0.87044903 |
| 87 | MP0003045_fibrosis | 0.86779308 |
| 88 | MP0001175_abnormal_lung_morphology | 0.86749357 |
| 89 | MP0001348_abnormal_lacrimal_gland | 0.86357887 |
| 90 | MP0002116_abnormal_craniofacial_bone | 0.85142526 |
| 91 | MP0001915_intracranial_hemorrhage | 0.85017847 |
| 92 | MP0000750_abnormal_muscle_regeneration | 0.84661006 |
| 93 | MP0000858_altered_metastatic_potential | 0.83130590 |
| 94 | MP0010630_abnormal_cardiac_muscle | 0.82423141 |
| 95 | MP0006138_congestive_heart_failure | 0.81739770 |
| 96 | MP0004883_abnormal_blood_vessel | 0.81423860 |
| 97 | MP0002697_abnormal_eye_size | 0.80371440 |
| 98 | MP0003755_abnormal_palate_morphology | 0.79696650 |
| 99 | MP0001542_abnormal_bone_strength | 0.79523590 |
| 100 | MP0004087_abnormal_muscle_fiber | 0.79032865 |
| 101 | MP0002249_abnormal_larynx_morphology | 0.79032072 |
| 102 | MP0003448_altered_tumor_morphology | 0.79026844 |
| 103 | MP0005164_abnormal_response_to | 0.78442745 |
| 104 | MP0003941_abnormal_skin_development | 0.77459467 |
| 105 | MP0004859_abnormal_synaptic_plasticity | 0.77430672 |
| 106 | MP0000467_abnormal_esophagus_morphology | 0.77300138 |
| 107 | MP0005595_abnormal_vascular_smooth | 0.76875239 |
| 108 | MP0002109_abnormal_limb_morphology | 0.76166432 |
| 109 | MP0004510_myositis | 0.75737886 |
| 110 | MP0005375_adipose_tissue_phenotype | 0.75409280 |
| 111 | MP0005058_abnormal_lysosome_morphology | 0.74327890 |
| 112 | MP0000759_abnormal_skeletal_muscle | 0.72760899 |
| 113 | MP0002114_abnormal_axial_skeleton | 0.72495727 |
| 114 | MP0002092_abnormal_eye_morphology | 0.72462336 |
| 115 | MP0001545_abnormal_hematopoietic_system | 0.72283624 |
| 116 | MP0005397_hematopoietic_system_phenotyp | 0.72283624 |
| 117 | MP0009672_abnormal_birth_weight | 0.72123970 |
| 118 | MP0002938_white_spotting | 0.71641565 |
| 119 | MP0000432_abnormal_head_morphology | 0.71502625 |
| 120 | MP0000003_abnormal_adipose_tissue | 0.71447923 |
| 121 | MP0000569_abnormal_digit_pigmentation | 0.70394164 |
| 122 | MP0000266_abnormal_heart_morphology | 0.69814336 |
| 123 | MP0003937_abnormal_limbs/digits/tail_de | 0.69667473 |
| 124 | MP0000747_muscle_weakness | 0.66951853 |
| 125 | MP0000566_synostosis | 0.65543948 |
| 126 | MP0002133_abnormal_respiratory_system | 0.65237301 |
| 127 | MP0005388_respiratory_system_phenotype | 0.65237301 |
| 128 | MP0005670_abnormal_white_adipose | 0.63774143 |
| 129 | MP0002085_abnormal_embryonic_tissue | 0.62707846 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Protrusio acetabuli (HP:0003179) | 7.24452434 |
| 2 | Premature rupture of membranes (HP:0001788) | 5.99782265 |
| 3 | Shallow orbits (HP:0000586) | 4.75291075 |
| 4 | Broad metatarsal (HP:0001783) | 4.42673364 |
| 5 | Aortic dissection (HP:0002647) | 4.03836278 |
| 6 | Bladder diverticulum (HP:0000015) | 3.84414922 |
| 7 | Cerebral aneurysm (HP:0004944) | 3.76751153 |
| 8 | Aortic aneurysm (HP:0004942) | 3.70673089 |
| 9 | Ankle contracture (HP:0006466) | 3.66053227 |
| 10 | Soft skin (HP:0000977) | 3.61801433 |
| 11 | Cervical subluxation (HP:0003308) | 3.50164992 |
| 12 | Peritonitis (HP:0002586) | 3.36007124 |
| 13 | Atrophic scars (HP:0001075) | 3.26243460 |
| 14 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 3.16749638 |
| 15 | Short 4th metacarpal (HP:0010044) | 3.16749638 |
| 16 | Fragile skin (HP:0001030) | 3.08608077 |
| 17 | Abnormality of dentin (HP:0010299) | 3.02493563 |
| 18 | Dilatation of the ascending aorta (HP:0005111) | 3.00639335 |
| 19 | Mitral valve prolapse (HP:0001634) | 2.96384314 |
| 20 | Follicular hyperkeratosis (HP:0007502) | 2.95529094 |
| 21 | Vascular tortuosity (HP:0004948) | 2.87787549 |
| 22 | Obstructive sleep apnea (HP:0002870) | 2.85699060 |
| 23 | Wormian bones (HP:0002645) | 2.84588296 |
| 24 | Vertebral compression fractures (HP:0002953) | 2.83739729 |
| 25 | Genu recurvatum (HP:0002816) | 2.77260591 |
| 26 | Thin bony cortex (HP:0002753) | 2.76818527 |
| 27 | Blue sclerae (HP:0000592) | 2.75005432 |
| 28 | Asymmetry of the thorax (HP:0001555) | 2.63236746 |
| 29 | Neonatal short-limb short stature (HP:0008921) | 2.62576380 |
| 30 | Arterial tortuosity (HP:0005116) | 2.62066742 |
| 31 | Spondylolisthesis (HP:0003302) | 2.60220597 |
| 32 | Abnormality of the 4th metacarpal (HP:0010012) | 2.56564758 |
| 33 | Bowel diverticulosis (HP:0005222) | 2.56215046 |
| 34 | Wrist flexion contracture (HP:0001239) | 2.54667001 |
| 35 | Spinal cord lesions (HP:0100561) | 2.48939928 |
| 36 | Syringomyelia (HP:0003396) | 2.48939928 |
| 37 | Mitral regurgitation (HP:0001653) | 2.42995150 |
| 38 | Deviation of the hallux (HP:0010051) | 2.42838833 |
| 39 | Buphthalmos (HP:0000557) | 2.40942514 |
| 40 | Hyperextensible skin (HP:0000974) | 2.40856696 |
| 41 | Biconcave vertebral bodies (HP:0004586) | 2.40804147 |
| 42 | Type 1 muscle fiber predominance (HP:0003803) | 2.39625121 |
| 43 | Aneurysm (HP:0002617) | 2.38910811 |
| 44 | Abnormality of the acetabulum (HP:0003170) | 2.35085252 |
| 45 | Radial bowing (HP:0002986) | 2.33740690 |
| 46 | Hallux valgus (HP:0001822) | 2.33023034 |
| 47 | * Spinal rigidity (HP:0003306) | 2.31865324 |
| 48 | Joint laxity (HP:0001388) | 2.31383077 |
| 49 | Broad ribs (HP:0000885) | 2.19776349 |
| 50 | Insomnia (HP:0100785) | 2.14608462 |
| 51 | Increased density of long bones (HP:0006392) | 2.14204466 |
| 52 | Bowing of the arm (HP:0006488) | 2.11193766 |
| 53 | Bowed forearm bones (HP:0003956) | 2.11193766 |
| 54 | Congenital glaucoma (HP:0001087) | 2.11000655 |
| 55 | Hematochezia (HP:0002573) | 2.08405386 |
| 56 | Slender build (HP:0001533) | 2.06029682 |
| 57 | Disproportionate tall stature (HP:0001519) | 2.05860471 |
| 58 | Spontaneous hematomas (HP:0007420) | 2.05744015 |
| 59 | Arnold-Chiari malformation (HP:0002308) | 2.04594353 |
| 60 | Achilles tendon contracture (HP:0001771) | 2.03528450 |
| 61 | Flat cornea (HP:0007720) | 2.03184115 |
| 62 | Ulnar bowing (HP:0003031) | 2.02867192 |
| 63 | Abnormality of the peritoneum (HP:0002585) | 2.00601069 |
| 64 | Short nail (HP:0001799) | 1.99187166 |
| 65 | Striae distensae (HP:0001065) | 1.98797263 |
| 66 | Renal duplication (HP:0000075) | 1.98725646 |
| 67 | Hyperacusis (HP:0010780) | 1.98227235 |
| 68 | Mesomelia (HP:0003027) | 1.91665410 |
| 69 | Thin ribs (HP:0000883) | 1.91307601 |
| 70 | Wide anterior fontanel (HP:0000260) | 1.90474823 |
| 71 | Exostoses (HP:0100777) | 1.89248543 |
| 72 | Increased connective tissue (HP:0009025) | 1.89135210 |
| 73 | Osteoarthritis (HP:0002758) | 1.88483488 |
| 74 | * Increased variability in muscle fiber diameter (HP:0003557) | 1.87535539 |
| 75 | Elfin facies (HP:0004428) | 1.87198694 |
| 76 | Femoral bowing (HP:0002980) | 1.86852204 |
| 77 | Distal lower limb amyotrophy (HP:0008944) | 1.86753125 |
| 78 | Difficulty climbing stairs (HP:0003551) | 1.86624487 |
| 79 | Elbow flexion contracture (HP:0002987) | 1.86216395 |
| 80 | Broad long bones (HP:0005622) | 1.85865466 |
| 81 | * Hypoventilation (HP:0002791) | 1.85009975 |
| 82 | Camptodactyly of toe (HP:0001836) | 1.84219720 |
| 83 | Renovascular hypertension (HP:0100817) | 1.83771133 |
| 84 | Overriding aorta (HP:0002623) | 1.83441541 |
| 85 | Ectopia lentis (HP:0001083) | 1.82947438 |
| 86 | Natal tooth (HP:0000695) | 1.81725860 |
| 87 | Scapular winging (HP:0003691) | 1.81666622 |
| 88 | Lymphangioma (HP:0100764) | 1.81368618 |
| 89 | Enlarged penis (HP:0000040) | 1.80918703 |
| 90 | Coronal craniosynostosis (HP:0004440) | 1.80293073 |
| 91 | Overgrowth (HP:0001548) | 1.79768259 |
| 92 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.79098871 |
| 93 | Limb-girdle muscle atrophy (HP:0003797) | 1.78823206 |
| 94 | Abnormality of the distal phalanx of the thumb (HP:0009617) | 1.76914907 |
| 95 | Osteopenia (HP:0000938) | 1.76465088 |
| 96 | Abnormality of the Achilles tendon (HP:0005109) | 1.76214038 |
| 97 | Bell-shaped thorax (HP:0001591) | 1.75952293 |
| 98 | Spinal cord compression (HP:0002176) | 1.75416188 |
| 99 | Distal lower limb muscle weakness (HP:0009053) | 1.74731500 |
| 100 | Coxa vara (HP:0002812) | 1.74675991 |
| 101 | Vertebral arch anomaly (HP:0008438) | 1.72845947 |
| 102 | Upper limb amyotrophy (HP:0009129) | 1.72842312 |
| 103 | Distal upper limb amyotrophy (HP:0007149) | 1.72842312 |
| 104 | Nonimmune hydrops fetalis (HP:0001790) | 1.70580830 |
| 105 | Venous abnormality (HP:0002624) | 1.70197920 |
| 106 | Aortic valve stenosis (HP:0001650) | 1.69760643 |
| 107 | Inguinal hernia (HP:0000023) | 1.69567790 |
| 108 | Hand muscle atrophy (HP:0009130) | 1.69378674 |
| 109 | Nuclear cataract (HP:0100018) | 1.69361764 |
| 110 | Aplasia involving bones of the extremities (HP:0009825) | 1.69291034 |
| 111 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.69291034 |
| 112 | Aplasia of the phalanges of the hand (HP:0009802) | 1.69291034 |
| 113 | * Abnormality of skeletal muscle fiber size (HP:0012084) | 1.68758451 |
| 114 | Bronchomalacia (HP:0002780) | 1.68560433 |
| 115 | Neurofibrillary tangles (HP:0002185) | 1.68520488 |
| 116 | Long toe (HP:0010511) | 1.67799867 |
| 117 | Flat acetabular roof (HP:0003180) | 1.67340609 |
| 118 | Back pain (HP:0003418) | 1.67251252 |
| 119 | Persistence of primary teeth (HP:0006335) | 1.67096535 |
| 120 | Mild short stature (HP:0003502) | 1.66885586 |
| 121 | Premature skin wrinkling (HP:0100678) | 1.66765451 |
| 122 | Hypoplasia of the iris (HP:0007676) | 1.66220886 |
| 123 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.65376624 |
| 124 | Osteolytic defects of the hand bones (HP:0009699) | 1.65376624 |
| 125 | Turricephaly (HP:0000262) | 1.64987465 |
| 126 | Joint stiffness (HP:0001387) | 1.64762519 |
| 127 | Platyspondyly (HP:0000926) | 1.64056367 |
| 128 | Abnormal delivery (HP:0001787) | 1.63776000 |
| 129 | Broad face (HP:0000283) | 1.63479172 |
| 130 | Slender long bone (HP:0003100) | 1.63088219 |
| 131 | Infantile muscular hypotonia (HP:0008947) | 1.61560882 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIB3 | 4.78064335 |
| 2 | PKN2 | 4.08081182 |
| 3 | TTN | 3.19017444 |
| 4 | TIE1 | 3.19003536 |
| 5 | ERN1 | 2.91929052 |
| 6 | DDR2 | 2.89328192 |
| 7 | PDGFRA | 2.75536662 |
| 8 | SMG1 | 2.65001852 |
| 9 | NTRK1 | 2.58820296 |
| 10 | RIPK1 | 2.56663482 |
| 11 | PTK6 | 2.50084099 |
| 12 | TGFBR2 | 2.37892714 |
| 13 | CDK12 | 2.26800530 |
| 14 | EPHB2 | 2.15939028 |
| 15 | PAK4 | 1.99177273 |
| 16 | EPHB1 | 1.94489376 |
| 17 | PTK2 | 1.93476305 |
| 18 | PRPF4B | 1.86437762 |
| 19 | CAMK1D | 1.79874111 |
| 20 | LRRK2 | 1.77969168 |
| 21 | TGFBR1 | 1.77203712 |
| 22 | FGFR4 | 1.74826551 |
| 23 | EEF2K | 1.67626586 |
| 24 | CDC42BPA | 1.59943985 |
| 25 | CAMK1G | 1.58092375 |
| 26 | EPHA3 | 1.56701018 |
| 27 | BMX | 1.52942484 |
| 28 | DMPK | 1.52818875 |
| 29 | RET | 1.45450168 |
| 30 | PAK2 | 1.44281930 |
| 31 | LATS2 | 1.40609869 |
| 32 | RPS6KA4 | 1.36727938 |
| 33 | LMTK2 | 1.32699646 |
| 34 | PDGFRB | 1.32679640 |
| 35 | ILK | 1.29360793 |
| 36 | LATS1 | 1.29258399 |
| 37 | KDR | 1.25983085 |
| 38 | FGFR1 | 1.25830239 |
| 39 | SIK1 | 1.21677884 |
| 40 | TRPM7 | 1.19764520 |
| 41 | PTK2B | 1.19264129 |
| 42 | CAMKK1 | 1.18573384 |
| 43 | EPHA2 | 1.11130861 |
| 44 | FER | 1.09175472 |
| 45 | ICK | 1.08692146 |
| 46 | SCYL2 | 1.06440293 |
| 47 | IRAK3 | 1.06271515 |
| 48 | MYLK | 1.05310597 |
| 49 | MAP3K10 | 1.01285843 |
| 50 | PRKG2 | 1.00792620 |
| 51 | MARK2 | 0.95742427 |
| 52 | CAMKK2 | 0.89433332 |
| 53 | MAP2K3 | 0.86499079 |
| 54 | CDK8 | 0.85832536 |
| 55 | KIT | 0.84683418 |
| 56 | PASK | 0.84674985 |
| 57 | ROCK2 | 0.84106136 |
| 58 | KSR2 | 0.83350967 |
| 59 | PRKD3 | 0.82351487 |
| 60 | ERBB4 | 0.81484966 |
| 61 | MTOR | 0.81225391 |
| 62 | CSK | 0.79750391 |
| 63 | MOS | 0.79701662 |
| 64 | STK38 | 0.79667419 |
| 65 | BTK | 0.78878533 |
| 66 | PAK3 | 0.78377232 |
| 67 | PRKD1 | 0.78275150 |
| 68 | ALK | 0.78239683 |
| 69 | MAP3K3 | 0.77348170 |
| 70 | TYRO3 | 0.76804933 |
| 71 | PIM2 | 0.73354698 |
| 72 | MAP3K4 | 0.73315197 |
| 73 | FGFR2 | 0.72997052 |
| 74 | ROCK1 | 0.72303224 |
| 75 | FLT3 | 0.71968936 |
| 76 | LIMK1 | 0.71715304 |
| 77 | BLK | 0.68550346 |
| 78 | CSNK1A1L | 0.68093515 |
| 79 | FGR | 0.67883523 |
| 80 | MAP3K6 | 0.66849452 |
| 81 | MET | 0.65793682 |
| 82 | PRKCH | 0.64263450 |
| 83 | PDPK1 | 0.61400492 |
| 84 | RPS6KA2 | 0.60738597 |
| 85 | TBK1 | 0.59931122 |
| 86 | ERBB3 | 0.59534296 |
| 87 | TAOK2 | 0.59327318 |
| 88 | CLK1 | 0.58616937 |
| 89 | MAPK7 | 0.58029009 |
| 90 | HCK | 0.57262120 |
| 91 | TESK1 | 0.54697593 |
| 92 | CSNK1G3 | 0.54595192 |
| 93 | CDK9 | 0.54522085 |
| 94 | SRC | 0.54416409 |
| 95 | MAP3K13 | 0.53836632 |
| 96 | ARAF | 0.53596160 |
| 97 | PAK6 | 0.51290319 |
| 98 | SGK3 | 0.50474509 |
| 99 | STK3 | 0.50129504 |
| 100 | NEK2 | 0.46943857 |
| 101 | ERBB2 | 0.46938470 |
| 102 | MAP2K1 | 0.46413710 |
| 103 | INSR | 0.45809417 |
| 104 | HIPK2 | 0.44708172 |
| 105 | ABL1 | 0.44657153 |
| 106 | FYN | 0.44646761 |
| 107 | MAP3K8 | 0.44451801 |
| 108 | GSK3A | 0.44106959 |
| 109 | STK10 | 0.44060112 |
| 110 | MKNK1 | 0.43142000 |
| 111 | CSNK1G1 | 0.42983854 |
| 112 | MAP3K7 | 0.40729258 |
| 113 | MAPKAPK2 | 0.38577184 |
| 114 | CDK6 | 0.36612046 |
| 115 | EGFR | 0.36392680 |
| 116 | RPS6KA6 | 0.36133751 |
| 117 | RPS6KL1 | 0.36080747 |
| 118 | RPS6KC1 | 0.36080747 |
| 119 | WNK1 | 0.35453376 |
| 120 | NEK9 | 0.35135950 |
| 121 | ZAP70 | 0.35033598 |
| 122 | PAK1 | 0.34703959 |
| 123 | CDK15 | 0.33879514 |
| 124 | CDK11A | 0.33849247 |
| 125 | FGFR3 | 0.32695560 |
| 126 | ABL2 | 0.32388584 |
| 127 | MAP3K1 | 0.32366730 |
| 128 | PRKD2 | 0.32363724 |
| 129 | NME2 | 0.31942554 |
| 130 | CDK7 | 0.31719819 |
| 131 | MAPK10 | 0.30533680 |
| 132 | TAOK1 | 0.29647384 |
| 133 | MAPK12 | 0.29538161 |
| 134 | AKT2 | 0.28739529 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ECM-receptor interaction_Homo sapiens_hsa04512 | 2.94246013 |
| 2 | Focal adhesion_Homo sapiens_hsa04510 | 2.40110644 |
| 3 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 2.31280686 |
| 4 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 2.00305803 |
| 5 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.99945308 |
| 6 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 1.96388336 |
| 7 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.73429156 |
| 8 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.71485866 |
| 9 | Other glycan degradation_Homo sapiens_hsa00511 | 1.68884143 |
| 10 | Amoebiasis_Homo sapiens_hsa05146 | 1.65816527 |
| 11 | Malaria_Homo sapiens_hsa05144 | 1.63328780 |
| 12 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.61161281 |
| 13 | Prion diseases_Homo sapiens_hsa05020 | 1.61154834 |
| 14 | Bladder cancer_Homo sapiens_hsa05219 | 1.61140123 |
| 15 | Adherens junction_Homo sapiens_hsa04520 | 1.59968502 |
| 16 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.57368614 |
| 17 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.56741946 |
| 18 | Shigellosis_Homo sapiens_hsa05131 | 1.51308388 |
| 19 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.48879953 |
| 20 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.48668686 |
| 21 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.44006926 |
| 22 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.42752710 |
| 23 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.42641413 |
| 24 | Axon guidance_Homo sapiens_hsa04360 | 1.36348850 |
| 25 | Viral myocarditis_Homo sapiens_hsa05416 | 1.36064325 |
| 26 | Platelet activation_Homo sapiens_hsa04611 | 1.34678603 |
| 27 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.30170778 |
| 28 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.30046519 |
| 29 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 1.29760334 |
| 30 | Protein digestion and absorption_Homo sapiens_hsa04974 | 1.28730853 |
| 31 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.27073801 |
| 32 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.26829182 |
| 33 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.25766819 |
| 34 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.24919701 |
| 35 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.24136858 |
| 36 | Salmonella infection_Homo sapiens_hsa05132 | 1.22099794 |
| 37 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.20307019 |
| 38 | Leishmaniasis_Homo sapiens_hsa05140 | 1.18849372 |
| 39 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.18621578 |
| 40 | Pathways in cancer_Homo sapiens_hsa05200 | 1.16098563 |
| 41 | Melanoma_Homo sapiens_hsa05218 | 1.15402726 |
| 42 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.14963753 |
| 43 | Thyroid cancer_Homo sapiens_hsa05216 | 1.14828180 |
| 44 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.14181886 |
| 45 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.13924972 |
| 46 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.12386154 |
| 47 | Colorectal cancer_Homo sapiens_hsa05210 | 1.11143492 |
| 48 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.07224659 |
| 49 | Phagosome_Homo sapiens_hsa04145 | 1.06953257 |
| 50 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.04939958 |
| 51 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.04429049 |
| 52 | Lysosome_Homo sapiens_hsa04142 | 1.03736269 |
| 53 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.03629297 |
| 54 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.03002345 |
| 55 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.02116205 |
| 56 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.98030767 |
| 57 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.98022185 |
| 58 | Pertussis_Homo sapiens_hsa05133 | 0.96854727 |
| 59 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.96311493 |
| 60 | HTLV-I infection_Homo sapiens_hsa05166 | 0.95781429 |
| 61 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.95342757 |
| 62 | Glioma_Homo sapiens_hsa05214 | 0.95213668 |
| 63 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.91390102 |
| 64 | Hepatitis B_Homo sapiens_hsa05161 | 0.90519933 |
| 65 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.89549130 |
| 66 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.88128505 |
| 67 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.84796252 |
| 68 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.84172680 |
| 69 | Lysine degradation_Homo sapiens_hsa00310 | 0.83060031 |
| 70 | Prostate cancer_Homo sapiens_hsa05215 | 0.82919448 |
| 71 | Tight junction_Homo sapiens_hsa04530 | 0.82790567 |
| 72 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.82726309 |
| 73 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.82368088 |
| 74 | Endocytosis_Homo sapiens_hsa04144 | 0.80682016 |
| 75 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.80102104 |
| 76 | Melanogenesis_Homo sapiens_hsa04916 | 0.79052728 |
| 77 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.78179875 |
| 78 | Gap junction_Homo sapiens_hsa04540 | 0.77585223 |
| 79 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.76526583 |
| 80 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.75266943 |
| 81 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.74696205 |
| 82 | Apoptosis_Homo sapiens_hsa04210 | 0.73542072 |
| 83 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.72819937 |
| 84 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.72817202 |
| 85 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.72707475 |
| 86 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.72228149 |
| 87 | Insulin resistance_Homo sapiens_hsa04931 | 0.72200188 |
| 88 | Galactose metabolism_Homo sapiens_hsa00052 | 0.71270839 |
| 89 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.69375485 |
| 90 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.68579711 |
| 91 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.68280603 |
| 92 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.68233539 |
| 93 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.68054768 |
| 94 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.67642765 |
| 95 | Endometrial cancer_Homo sapiens_hsa05213 | 0.66892227 |
| 96 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.65063936 |
| 97 | Tuberculosis_Homo sapiens_hsa05152 | 0.64612459 |
| 98 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.64571177 |
| 99 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.64445486 |
| 100 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.64363447 |
| 101 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.63628707 |
| 102 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.62803182 |
| 103 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.61352118 |
| 104 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.61186540 |
| 105 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.61086261 |
| 106 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.60263324 |
| 107 | Long-term potentiation_Homo sapiens_hsa04720 | 0.59634530 |
| 108 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.59085709 |
| 109 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.57321030 |
| 110 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.56168252 |
| 111 | Cocaine addiction_Homo sapiens_hsa05030 | 0.55048794 |
| 112 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.54895724 |
| 113 | Protein export_Homo sapiens_hsa03060 | 0.54660135 |
| 114 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.54459284 |
| 115 | Long-term depression_Homo sapiens_hsa04730 | 0.54233478 |
| 116 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.53210932 |
| 117 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.52840813 |
| 118 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.52664630 |
| 119 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.50778404 |
| 120 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.49360035 |
| 121 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.47517503 |
| 122 | Hepatitis C_Homo sapiens_hsa05160 | 0.46100610 |

