SEPP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.69512354
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.69512354
3L-phenylalanine metabolic process (GO:0006558)6.34829254
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.34829254
5angiotensin maturation (GO:0002003)6.17578576
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.97647062
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.80371435
8aromatic amino acid family catabolic process (GO:0009074)5.79766337
9epoxygenase P450 pathway (GO:0019373)5.66322432
10alpha-linolenic acid metabolic process (GO:0036109)5.21494524
11high-density lipoprotein particle remodeling (GO:0034375)5.17166632
12indole-containing compound catabolic process (GO:0042436)5.05584926
13indolalkylamine catabolic process (GO:0046218)5.05584926
14tryptophan catabolic process (GO:0006569)5.05584926
15bile acid biosynthetic process (GO:0006699)4.99720765
16glyoxylate metabolic process (GO:0046487)4.98847117
17fat-soluble vitamin biosynthetic process (GO:0042362)4.97814230
18negative regulation of fibrinolysis (GO:0051918)4.92401877
19regulation of cholesterol esterification (GO:0010872)4.90990545
20kynurenine metabolic process (GO:0070189)4.88604962
21protein carboxylation (GO:0018214)4.88270515
22peptidyl-glutamic acid carboxylation (GO:0017187)4.88270515
23tryptophan metabolic process (GO:0006568)4.84151544
24reverse cholesterol transport (GO:0043691)4.82443728
25sulfur amino acid catabolic process (GO:0000098)4.81642550
26intestinal absorption (GO:0050892)4.78925934
27cysteine metabolic process (GO:0006534)4.73551248
28urea metabolic process (GO:0019627)4.71060990
29urea cycle (GO:0000050)4.71060990
30complement activation, alternative pathway (GO:0006957)4.69560148
31phospholipid efflux (GO:0033700)4.69020967
32regulation of fibrinolysis (GO:0051917)4.67570551
33regulation of protein activation cascade (GO:2000257)4.65666256
34fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.58306014
35lipoprotein transport (GO:0042953)4.52968078
36protein-lipid complex remodeling (GO:0034368)4.52197049
37macromolecular complex remodeling (GO:0034367)4.52197049
38plasma lipoprotein particle remodeling (GO:0034369)4.52197049
39bile acid metabolic process (GO:0008206)4.44199898
40regulation of triglyceride catabolic process (GO:0010896)4.41885866
41regulation of complement activation (GO:0030449)4.39211454
42nitrogen cycle metabolic process (GO:0071941)4.32854611
43plasma lipoprotein particle clearance (GO:0034381)4.31052168
44homocysteine metabolic process (GO:0050667)4.27636624
45NADH metabolic process (GO:0006734)4.25561349
46cholesterol efflux (GO:0033344)4.21365613
47serine family amino acid catabolic process (GO:0009071)4.17990054
48aromatic amino acid family metabolic process (GO:0009072)4.16984444
49tyrosine metabolic process (GO:0006570)4.16793987
50negative regulation of cholesterol transport (GO:0032375)4.15546592
51negative regulation of sterol transport (GO:0032372)4.15546592
52triglyceride homeostasis (GO:0070328)4.15363160
53acylglycerol homeostasis (GO:0055090)4.15363160
54drug metabolic process (GO:0017144)4.11149967
55lysine metabolic process (GO:0006553)4.10902861
56lysine catabolic process (GO:0006554)4.10902861
57amino-acid betaine metabolic process (GO:0006577)4.10162221
58low-density lipoprotein particle remodeling (GO:0034374)4.06660872
59plasma lipoprotein particle assembly (GO:0034377)4.05148823
60bile acid and bile salt transport (GO:0015721)3.99487954
61diacylglycerol metabolic process (GO:0046339)3.99213616
62drug catabolic process (GO:0042737)3.98236548
63fructose metabolic process (GO:0006000)3.95844243
64alpha-amino acid catabolic process (GO:1901606)3.94759160
65phospholipid homeostasis (GO:0055091)3.93736266
66cellular ketone body metabolic process (GO:0046950)3.90317559
67hormone catabolic process (GO:0042447)3.84697079
68cellular modified amino acid catabolic process (GO:0042219)3.73529813
69cellular amino acid catabolic process (GO:0009063)3.71691149
70protein-lipid complex assembly (GO:0065005)3.70696218
71glutamate metabolic process (GO:0006536)3.65673620
72cellular glucuronidation (GO:0052695)3.65607654
73cholesterol homeostasis (GO:0042632)3.62596464
74coenzyme catabolic process (GO:0009109)3.62465514
75plasma lipoprotein particle organization (GO:0071827)3.62116900
76indolalkylamine metabolic process (GO:0006586)3.61272969
77amine catabolic process (GO:0009310)3.61235851
78cellular biogenic amine catabolic process (GO:0042402)3.61235851
79sterol homeostasis (GO:0055092)3.58120350
80negative regulation of lipase activity (GO:0060192)3.55014155
81benzene-containing compound metabolic process (GO:0042537)3.55013154
82fibrinolysis (GO:0042730)3.53589648
83short-chain fatty acid metabolic process (GO:0046459)3.52999733
84drug transmembrane transport (GO:0006855)3.50396845
85positive regulation of triglyceride lipase activity (GO:0061365)3.50336099
86positive regulation of lipoprotein lipase activity (GO:0051006)3.50336099
87virion attachment to host cell (GO:0019062)3.50042912
88adhesion of symbiont to host cell (GO:0044650)3.50042912
89lipoprotein metabolic process (GO:0042157)3.49826551
90ethanol oxidation (GO:0006069)3.47978235
91very-low-density lipoprotein particle assembly (GO:0034379)3.47957736
92adhesion of symbiont to host (GO:0044406)3.47308885
93protein activation cascade (GO:0072376)3.46430755
94protein-lipid complex subunit organization (GO:0071825)3.44888415
95positive regulation of lipid catabolic process (GO:0050996)3.44055722
96omega-hydroxylase P450 pathway (GO:0097267)3.43364293
97complement activation (GO:0006956)3.41957760
98flavonoid metabolic process (GO:0009812)3.40288624
99exogenous drug catabolic process (GO:0042738)3.40263393
100regulation of cholesterol homeostasis (GO:2000188)3.39216393
101complement activation, classical pathway (GO:0006958)3.38904708
102cofactor catabolic process (GO:0051187)3.38066922
103organic acid catabolic process (GO:0016054)3.37628380
104carboxylic acid catabolic process (GO:0046395)3.37628380
105serine family amino acid metabolic process (GO:0009069)3.37563894
106ketone body metabolic process (GO:1902224)3.37071865
107aldehyde catabolic process (GO:0046185)3.34122441
108dicarboxylic acid biosynthetic process (GO:0043650)3.32644161
109urate metabolic process (GO:0046415)3.32643878
110arginine metabolic process (GO:0006525)3.32486755
111ethanol metabolic process (GO:0006067)3.32288102
112glucuronate metabolic process (GO:0019585)3.32150204
113uronic acid metabolic process (GO:0006063)3.32150204
114regulation of cholesterol biosynthetic process (GO:0045540)3.30913452
115regulation of bile acid biosynthetic process (GO:0070857)3.30652001
116fatty acid oxidation (GO:0019395)3.29983318
117glycosphingolipid catabolic process (GO:0046479)3.26846402
118negative regulation of blood coagulation (GO:0030195)3.26121674
119negative regulation of hemostasis (GO:1900047)3.26121674
120regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.25892751
121endocrine process (GO:0050886)3.25892751
122regulation of systemic arterial blood pressure by hormone (GO:0001990)3.25892751
123positive regulation of fatty acid biosynthetic process (GO:0045723)3.25035229
124acute-phase response (GO:0006953)3.23398152
125intestinal cholesterol absorption (GO:0030299)3.20623730
126negative regulation of protein activation cascade (GO:2000258)3.20373446
127transcytosis (GO:0045056)3.19890608
128blood coagulation, intrinsic pathway (GO:0007597)3.16786975
129renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.15767925
130regulation of apoptotic cell clearance (GO:2000425)3.12239551
131glycolipid catabolic process (GO:0019377)3.09614779
132peptide catabolic process (GO:0043171)3.05092903
133negative regulation of coagulation (GO:0050819)3.03856367
134regulation of guanylate cyclase activity (GO:0031282)2.99028193
135renal system process involved in regulation of blood volume (GO:0001977)2.93262956
136regulation of cholesterol metabolic process (GO:0090181)2.87973380
137glutamine family amino acid biosynthetic process (GO:0009084)2.87638649
138low-density lipoprotein particle clearance (GO:0034383)2.87272754
139positive regulation of steroid metabolic process (GO:0045940)2.86112745
140L-ascorbic acid metabolic process (GO:0019852)2.84444244
141negative regulation of wound healing (GO:0061045)2.79952530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.89541147
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.14658806
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.08460925
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.77171742
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.54001911
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79786315
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.54988062
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.02858951
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.45736539
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.11248542
11CLOCK_20551151_ChIP-Seq_293T_Human2.07795265
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.06753770
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93625953
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73619790
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.70428526
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62882638
17GATA1_22025678_ChIP-Seq_K562_Human1.61993669
18* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.61080143
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.57232844
20* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57081799
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.57044985
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56025220
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.41728012
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38966427
25HTT_18923047_ChIP-ChIP_STHdh_Human1.24202610
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.24177008
27BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23750723
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.22593304
29* HNF4A_19822575_ChIP-Seq_HepG2_Human1.21957640
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21463393
31SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19309790
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.18339029
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17357539
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16350796
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16035060
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15860568
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15006746
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.11686060
39* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07730066
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07040035
41* IRF8_27001747_Chip-Seq_BMDM_Mouse1.04676083
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04332433
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.04135224
44ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02319518
45ZNF263_19887448_ChIP-Seq_K562_Human1.00982622
46SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00715241
47ESR1_20079471_ChIP-ChIP_T-47D_Human0.98591392
48RACK7_27058665_Chip-Seq_MCF-7_Human0.97857950
49NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97774485
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97774485
51GATA4_25053715_ChIP-Seq_YYC3_Human0.95431873
52CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94735306
53DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94517583
54CDX2_20551321_ChIP-Seq_CACO-2_Human0.93390899
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93047372
56* GATA1_19941826_ChIP-Seq_K562_Human0.91753932
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91029002
58RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89179211
59* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86778561
60* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85923524
61PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83918974
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83531942
63FOXO3_23340844_ChIP-Seq_DLD1_Human0.83390252
64* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82878717
65EGR1_19032775_ChIP-ChIP_M12_Human0.82006557
66SOX2_20726797_ChIP-Seq_SW620_Human0.81209283
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80979017
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79881171
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79473356
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79172326
71ERG_21242973_ChIP-ChIP_JURKAT_Human0.77047926
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75907642
73* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72832390
74IRF8_21731497_ChIP-ChIP_J774_Mouse0.72191093
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71811092
76* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71327003
77GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71104023
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.70218510
79* GATA2_19941826_ChIP-Seq_K562_Human0.70212048
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.70164811
81MYB_21317192_ChIP-Seq_ERMYB_Mouse0.69693899
82LXR_22292898_ChIP-Seq_THP-1_Human0.69013762
83CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67926500
84* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67425322
85RUNX1_27514584_Chip-Seq_MCF-7_Human0.67160018
86DROSHA_22980978_ChIP-Seq_HELA_Human0.66581044
87* FOXA1_25552417_ChIP-Seq_VCAP_Human0.66249354
88SA1_27219007_Chip-Seq_Bcells_Human0.64582561
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.63814487
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63691201
91CDX2_22108803_ChIP-Seq_LS180_Human0.63256586
92RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62514385
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62282305
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.61017135
95* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60722752
96TRIM28_21343339_ChIP-Seq_HEK293_Human0.60266515
97PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.58843634
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.58798219
99BCAT_22108803_ChIP-Seq_LS180_Human0.58752577
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58072607
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57250944
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.57239575
103* CEBPB_22108803_ChIP-Seq_LS180_Human0.56217765
104VDR_24787735_ChIP-Seq_THP-1_Human0.55692368
105CBP_21632823_ChIP-Seq_H3396_Human0.53924960
106* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52873089
107* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52777173
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.52213941
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.51444125
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.51444125
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.51297043
112TP63_23658742_ChIP-Seq_EP156T_Human0.51202111
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.50295150
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.50283769
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.50215528
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.49907767
117MYC_19915707_ChIP-ChIP_AK7_Human0.49778804
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.49345879
119BRD4_27068464_Chip-Seq_AML-cells_Mouse0.49291191
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.48263537
121P63_26484246_Chip-Seq_KERATINOCYTES_Human0.47786372
122ESET_19884257_ChIP-Seq_ESCs_Mouse0.47550114
123PIAS1_25552417_ChIP-Seq_VCAP_Human0.47245311
124AR_20517297_ChIP-Seq_VCAP_Human0.47220657
125GATA6_25053715_ChIP-Seq_YYC3_Human0.46596029
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.46392249
127* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.46189256
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.46164841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.14685208
2MP0005360_urolithiasis6.71540617
3MP0005085_abnormal_gallbladder_physiolo5.48964242
4MP0005365_abnormal_bile_salt5.38196720
5MP0008875_abnormal_xenobiotic_pharmacok4.53622210
6MP0009840_abnormal_foam_cell3.92096419
7MP0003252_abnormal_bile_duct3.53852385
8MP0010329_abnormal_lipoprotein_level3.41759780
9MP0003806_abnormal_nucleotide_metabolis3.22954113
10MP0003191_abnormal_cellular_cholesterol2.97920226
11MP0005083_abnormal_biliary_tract2.74558234
12MP0005332_abnormal_amino_acid2.65785702
13MP0003195_calcinosis2.65174529
14MP0003183_abnormal_peptide_metabolism2.62610834
15MP0001666_abnormal_nutrient_absorption2.61714290
16MP0004019_abnormal_vitamin_homeostasis2.38408942
17MP0002118_abnormal_lipid_homeostasis2.08067751
18MP0002138_abnormal_hepatobiliary_system2.07456545
19* MP0000609_abnormal_liver_physiology2.05894160
20MP0010368_abnormal_lymphatic_system2.02297981
21MP0004264_abnormal_extraembryonic_tissu1.76304765
22MP0003303_peritoneal_inflammation1.67702000
23MP0005319_abnormal_enzyme/_coenzyme1.67582098
24MP0010155_abnormal_intestine_physiology1.65163808
25MP0005058_abnormal_lysosome_morphology1.64907253
26MP0005409_darkened_coat_color1.58322850
27MP0005584_abnormal_enzyme/coenzyme_acti1.57982915
28MP0003724_increased_susceptibility_to1.56249651
29MP0002254_reproductive_system_inflammat1.53290122
30MP0003690_abnormal_glial_cell1.52986818
31MP0009643_abnormal_urine_homeostasis1.51788783
32MP0000604_amyloidosis1.47860337
33MP0003868_abnormal_feces_composition1.45269257
34MP0010234_abnormal_vibrissa_follicle1.39632982
35MP0005670_abnormal_white_adipose1.38663328
36MP0001764_abnormal_homeostasis1.33799527
37MP0003879_abnormal_hair_cell1.27103402
38MP0004147_increased_porphyrin_level1.25451023
39MP0003011_delayed_dark_adaptation1.21517948
40MP0003186_abnormal_redox_activity1.20146226
41MP0005451_abnormal_body_composition1.19624765
42MP0009764_decreased_sensitivity_to1.14392707
43MP0003300_gastrointestinal_ulcer1.11157690
44MP0009697_abnormal_copulation1.10796618
45MP0005167_abnormal_blood-brain_barrier1.10215462
46MP0000598_abnormal_liver_morphology1.09218803
47MP0008469_abnormal_protein_level1.07166513
48MP0009785_altered_susceptibility_to1.06896289
49MP0009379_abnormal_foot_pigmentation1.05782126
50MP0004130_abnormal_muscle_cell1.05535717
51MP0003656_abnormal_erythrocyte_physiolo1.05426346
52MP0003705_abnormal_hypodermis_morpholog1.04870371
53* MP0009763_increased_sensitivity_to1.00792342
54MP0006054_spinal_hemorrhage0.97328600
55MP0003866_abnormal_defecation0.97242315
56* MP0005636_abnormal_mineral_homeostasis0.96187973
57MP0001879_abnormal_lymphatic_vessel0.90836437
58MP0009642_abnormal_blood_homeostasis0.89865606
59MP0001664_abnormal_digestion0.89131633
60MP0005084_abnormal_gallbladder_morpholo0.85295997
61MP0002998_abnormal_bone_remodeling0.84831901
62MP0001756_abnormal_urination0.84318867
63MP0005647_abnormal_sex_gland0.83802148
64MP0003329_amyloid_beta_deposits0.82205843
65MP0002078_abnormal_glucose_homeostasis0.81152973
66MP0004858_abnormal_nervous_system0.79848315
67MP0005464_abnormal_platelet_physiology0.79697661
68MP0003075_altered_response_to0.78216764
69MP0005408_hypopigmentation0.78170000
70MP0002971_abnormal_brown_adipose0.76909814
71MP0006082_CNS_inflammation0.76601958
72MP0005334_abnormal_fat_pad0.74113341
73* MP0005025_abnormal_response_to0.74098479
74MP0002136_abnormal_kidney_physiology0.73884172
75MP0009765_abnormal_xenobiotic_induced0.72281116
76MP0005023_abnormal_wound_healing0.71732301
77MP0001501_abnormal_sleep_pattern0.71663730
78MP0005376_homeostasis/metabolism_phenot0.71537058
79MP0000013_abnormal_adipose_tissue0.70500354
80MP0003436_decreased_susceptibility_to0.70480413
81MP0000477_abnormal_intestine_morphology0.70119265
82MP0001661_extended_life_span0.70100484
83MP0005535_abnormal_body_temperature0.70040042
84MP0005666_abnormal_adipose_tissue0.68408055
85MP0002896_abnormal_bone_mineralization0.67895797
86MP0010352_gastrointestinal_tract_polyps0.67159094
87MP0001790_abnormal_immune_system0.66984448
88MP0005387_immune_system_phenotype0.66984448
89MP0001663_abnormal_digestive_system0.66081543
90MP0008438_abnormal_cutaneous_collagen0.63981506
91MP0000249_abnormal_blood_vessel0.63324238
92MP0003453_abnormal_keratinocyte_physiol0.63087790
93MP0002876_abnormal_thyroid_physiology0.63012937
94MP0000566_synostosis0.62850383
95MP0004043_abnormal_pH_regulation0.62381025
96MP0002148_abnormal_hypersensitivity_rea0.61489255
97MP0004782_abnormal_surfactant_physiolog0.60956652
98MP0002089_abnormal_postnatal_growth/wei0.60927204
99MP0005164_abnormal_response_to0.60434430
100MP0000639_abnormal_adrenal_gland0.60314315
101MP0003638_abnormal_response/metabolism_0.59436176
102MP0000538_abnormal_urinary_bladder0.59359716
103MP0005220_abnormal_exocrine_pancreas0.58466503
104MP0002419_abnormal_innate_immunity0.58274975
105MP0000230_abnormal_systemic_arterial0.57625774
106MP0008004_abnormal_stomach_pH0.56605795
107MP0006036_abnormal_mitochondrial_physio0.54944215
108MP0004883_abnormal_blood_vessel0.54596221
109MP0005448_abnormal_energy_balance0.54475052
110MP0001533_abnormal_skeleton_physiology0.54353690
111MP0000920_abnormal_myelination0.53544787
112MP0003633_abnormal_nervous_system0.53003150
113MP0002295_abnormal_pulmonary_circulatio0.52709810
114MP0004947_skin_inflammation0.52189501
115MP0003172_abnormal_lysosome_physiology0.51770826
116MP0005166_decreased_susceptibility_to0.51590692
117MP0001845_abnormal_inflammatory_respons0.51553389
118MP0000858_altered_metastatic_potential0.51167882
119MP0001765_abnormal_ion_homeostasis0.50949527
120MP0008873_increased_physiological_sensi0.49070123
121MP0008874_decreased_physiological_sensi0.45285791
122MP0009115_abnormal_fat_cell0.44592301
123MP0005375_adipose_tissue_phenotype0.43896246
124MP0002090_abnormal_vision0.43361836
125MP0001243_abnormal_dermal_layer0.42161440
126MP0002928_abnormal_bile_duct0.41588410
127MP0003953_abnormal_hormone_level0.41320977
128MP0005165_increased_susceptibility_to0.40697922
129MP0000343_altered_response_to0.40382949
130MP0005595_abnormal_vascular_smooth0.40115076

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.60733539
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.34674001
3Intrahepatic cholestasis (HP:0001406)6.18068765
4Xanthomatosis (HP:0000991)5.94286401
5Prolonged partial thromboplastin time (HP:0003645)5.65321023
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.51283291
7Complement deficiency (HP:0004431)5.49114656
8Hypobetalipoproteinemia (HP:0003563)5.17343729
9Hyperlipoproteinemia (HP:0010980)4.94863514
10Joint hemorrhage (HP:0005261)4.65737622
11Hypolipoproteinemia (HP:0010981)4.33748787
12Systemic lupus erythematosus (HP:0002725)4.18923479
13Hypoalphalipoproteinemia (HP:0003233)4.17141236
14Abnormality of the common coagulation pathway (HP:0010990)4.13050997
15Hyperammonemia (HP:0001987)4.06675358
16Abnormality of complement system (HP:0005339)4.05694402
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.04160101
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01164901
19Epidermoid cyst (HP:0200040)3.93391865
20Hypoglycemic coma (HP:0001325)3.91330280
21Ketosis (HP:0001946)3.90243813
22Fat malabsorption (HP:0002630)3.68917325
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.68520200
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.68273538
25Hyperglycinuria (HP:0003108)3.65467822
26Glomerulonephritis (HP:0000099)3.63407283
27Hyperglycinemia (HP:0002154)3.62386469
28Abnormality of serine family amino acid metabolism (HP:0010894)3.60294099
29Abnormality of glycine metabolism (HP:0010895)3.60294099
30Abnormality of the intrinsic pathway (HP:0010989)3.54435147
31Abnormality of methionine metabolism (HP:0010901)3.52671224
32Hypercholesterolemia (HP:0003124)3.46324800
33Conjugated hyperbilirubinemia (HP:0002908)3.44553610
34Abnormality of fatty-acid metabolism (HP:0004359)3.20018055
35Myocardial infarction (HP:0001658)3.09906850
36Ketoacidosis (HP:0001993)3.08331921
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.05310253
38Widely patent fontanelles and sutures (HP:0004492)2.96078612
39Vascular calcification (HP:0004934)2.86739549
40Hyperbilirubinemia (HP:0002904)2.86643470
41Abnormality of purine metabolism (HP:0004352)2.85982227
42Abnormality of nucleobase metabolism (HP:0010932)2.83514738
43Abnormality of pyrimidine metabolism (HP:0004353)2.78579759
44Skin nodule (HP:0200036)2.75377529
45Hypoglycemic seizures (HP:0002173)2.74623982
46Steatorrhea (HP:0002570)2.70182522
47Amyloidosis (HP:0011034)2.68152998
48Nausea (HP:0002018)2.65478546
49Hepatocellular carcinoma (HP:0001402)2.62580633
50Delayed CNS myelination (HP:0002188)2.59448490
51Cardiovascular calcification (HP:0011915)2.56349373
52Facial shape deformation (HP:0011334)2.55774093
53Potter facies (HP:0002009)2.55774093
54Purpura (HP:0000979)2.54351122
55Pigmentary retinal degeneration (HP:0001146)2.53116968
56Abnormality of vitamin metabolism (HP:0100508)2.52088366
57Gout (HP:0001997)2.50772194
58Ileus (HP:0002595)2.49235659
59Dysostosis multiplex (HP:0000943)2.48156481
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44536155
61Dicarboxylic aciduria (HP:0003215)2.44536155
62Metabolic acidosis (HP:0001942)2.43701902
63Esophageal varix (HP:0002040)2.42034034
64Axonal loss (HP:0003447)2.41688545
65Nephritis (HP:0000123)2.39650001
66Abnormality of liposaccharide metabolism (HP:0010968)2.39528617
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.39528617
68Abnormality of glycolipid metabolism (HP:0010969)2.39528617
69Abnormality of serum amino acid levels (HP:0003112)2.39003452
70Late onset (HP:0003584)2.34986630
71Urinary glycosaminoglycan excretion (HP:0003541)2.33863486
72Mucopolysacchariduria (HP:0008155)2.33863486
73Generalized aminoaciduria (HP:0002909)2.33163072
74Hypophosphatemia (HP:0002148)2.33040100
75Spontaneous abortion (HP:0005268)2.32100764
76Nonimmune hydrops fetalis (HP:0001790)2.32089983
77Flat acetabular roof (HP:0003180)2.29541274
78Sensorimotor neuropathy (HP:0007141)2.27173823
79Chronic diarrhea (HP:0002028)2.26573419
80Hyperinsulinemic hypoglycemia (HP:0000825)2.23732847
81Irritability (HP:0000737)2.23434342
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21343970
83Abnormality of polysaccharide metabolism (HP:0011012)2.21343970
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21343970
85Wide cranial sutures (HP:0010537)2.20530411
86Mitral stenosis (HP:0001718)2.20493786
87Lethargy (HP:0001254)2.19028672
88Acanthocytosis (HP:0001927)2.18102043
89Neurofibrillary tangles (HP:0002185)2.18013729
90Abnormality of proline metabolism (HP:0010907)2.16121666
91Hydroxyprolinuria (HP:0003080)2.16121666
92Recurrent gram-negative bacterial infections (HP:0005420)2.14174635
93Abnormality of urine glucose concentration (HP:0011016)2.12320944
94Pancreatitis (HP:0001733)2.12198183
95Malnutrition (HP:0004395)2.12170105
96Alkalosis (HP:0001948)2.11217302
97Abnormal gallbladder morphology (HP:0012437)2.07926078
98Abnormality of the vitamin B12 metabolism (HP:0004341)2.06474612
99Hypotension (HP:0002615)2.05975636
100Hyperactive renin-angiotensin system (HP:0000841)2.05663042
101Confusion (HP:0001289)2.05084901
102Vacuolated lymphocytes (HP:0001922)2.04071041
103Rickets (HP:0002748)2.03703309
104Abnormal gallbladder physiology (HP:0012438)2.02707960
105Cholecystitis (HP:0001082)2.02707960
106Abnormal tarsal ossification (HP:0008369)2.01434296
107Gingival bleeding (HP:0000225)2.01385369
108Abnormality of carpal bone ossification (HP:0006257)2.00682127
109Thin bony cortex (HP:0002753)2.00241168
110Abdominal distention (HP:0003270)1.99767308
111Abnormal enzyme/coenzyme activity (HP:0012379)1.96965367
112Hypophosphatemic rickets (HP:0004912)1.96881406
113Cholelithiasis (HP:0001081)1.96615138
114Proximal tubulopathy (HP:0000114)1.96313527
115Hemorrhage of the eye (HP:0011885)1.95868200
116Spastic diplegia (HP:0001264)1.95101084
117Thrombophlebitis (HP:0004418)1.94991445
118Eczematoid dermatitis (HP:0000976)1.94518329
119Hypochromic microcytic anemia (HP:0004840)1.93327660
120Abnormality of transition element cation homeostasis (HP:0011030)1.92570450
121Vomiting (HP:0002013)1.92102299
122Metabolic alkalosis (HP:0200114)1.91525878
123Focal segmental glomerulosclerosis (HP:0000097)1.91521380
124Abnormality of iron homeostasis (HP:0011031)1.91360067
125Abnormality of vitamin B metabolism (HP:0004340)1.91320373
126Symptomatic seizures (HP:0011145)1.90763045
127Menorrhagia (HP:0000132)1.89173353
128Nephrolithiasis (HP:0000787)1.88662110
129Hyperuricemia (HP:0002149)1.87007545
130Increased purine levels (HP:0004368)1.87007545
131Enlarged kidneys (HP:0000105)1.86114593
132Peripheral demyelination (HP:0011096)1.82659947
133Elevated alkaline phosphatase (HP:0003155)1.81668778
134Neonatal onset (HP:0003623)1.80752187
135Glycosuria (HP:0003076)1.80292860
136Metaphyseal irregularity (HP:0003025)1.79773483
137Protuberant abdomen (HP:0001538)1.76821915
138Joint swelling (HP:0001386)1.75343111
139Decreased circulating renin level (HP:0003351)1.75187251
140Abnormality of alkaline phosphatase activity (HP:0004379)1.74007567
141Pulmonary embolism (HP:0002204)1.72838315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.27103947
2BCKDK4.72351097
3ACVR1B4.42746131
4ERN14.00622876
5TIE13.26645839
6TGFBR23.26066540
7SIK13.09295174
8INSRR3.00184195
9FGFR42.99906575
10DDR22.64635857
11TAOK32.39989778
12EPHB12.19211345
13TYK22.05124223
14BLK1.98297863
15PDGFRA1.78311331
16PRPF4B1.71008908
17MST1R1.70768611
18TRIB31.61519249
19PTK61.58589823
20JAK11.55609179
21PIK3CG1.52391282
22ICK1.50830849
23MAPK151.43161148
24CDC42BPA1.42469665
25JAK21.39378095
26PKN21.38375883
27EPHA21.37968894
28MATK1.36568050
29CAMK1D1.35651236
30FRK1.34265315
31NEK91.29432663
32TBK11.23812991
33MET1.23271712
34IRAK31.23172693
35AKT31.18857434
36TYRO31.18186596
37FLT31.17501023
38ERBB41.16835920
39MAPK111.14983018
40FGFR21.12445080
41MAPK121.06652028
42MAP2K41.05641140
43PRKAA21.05527094
44MAP3K141.04936336
45DAPK21.04291657
46MAP2K20.95470761
47GRK10.92372963
48MAP2K30.89155552
49MYLK0.87621876
50WNK40.87032682
51CAMK1G0.86821795
52GSK3A0.86553430
53MAP3K100.85097072
54RIPK10.84825340
55CSK0.84561821
56RIPK40.84264810
57MAP3K30.83154573
58TESK20.83120808
59STK240.82737645
60LMTK20.80870920
61ABL20.79230358
62FGR0.78424054
63TESK10.78117365
64TAOK10.77188174
65KSR20.75894099
66MAP3K70.74884641
67LATS10.74711708
68MAP2K60.73495256
69EPHA30.72890920
70CSF1R0.72150819
71TAOK20.71788236
72MAPK40.70267011
73EPHA40.70103537
74PINK10.68496199
75IGF1R0.67389520
76NLK0.66382161
77EPHB20.65558772
78PDPK10.65044913
79EEF2K0.64871791
80GRK70.64508396
81MAP3K120.63797687
82MAPK70.63566518
83SGK4940.63054566
84SGK2230.63054566
85PTK20.62637947
86MAP3K20.60844162
87GRK60.59498331
88IKBKE0.58151677
89MAPKAPK30.57737264
90OXSR10.56784368
91PRKACG0.56065927
92RET0.54577853
93CAMK40.54058432
94MAP2K10.53180552
95MAP3K10.53073812
96SRC0.52526646
97PRKD10.52323198
98ITK0.52081605
99PKN10.51900848
100ERBB20.51590952
101STK390.50176784
102PRKG20.48410377
103TGFBR10.47855820
104FGFR30.47601991
105PRKCZ0.47432070
106SGK30.47325615
107CDK60.47207524
108EGFR0.47081566
109PDK20.46744571
110PDK10.46119690
111DYRK1B0.46119646
112PDGFRB0.44896571
113JAK30.44291346
114CAMKK20.44229296
115ZAP700.43635747
116LATS20.43353746
117PAK40.43211992
118PRKAA10.43120971
119PIM20.42923829
120NTRK10.42435241
121FYN0.42294054
122CAMK2G0.41838836
123BMPR20.41810700
124PRKCQ0.41460299
125KIT0.40177107
126MAP3K50.39058769
127CAMK2D0.37514657
128YES10.36507477
129LYN0.36505800
130PRKCA0.34744051
131PIK3CA0.32255168
132MAP3K110.31391063
133WNK30.31176903
134IRAK10.30853153
135FER0.29428657
136IRAK20.29266290
137MAP4K10.29073077
138PRKCD0.26392194
139MAP3K130.25383707

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.97576569
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.93684020
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22562466
4Complement and coagulation cascades_Homo sapiens_hsa046102.85176804
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.80365539
6Arginine biosynthesis_Homo sapiens_hsa002202.80086766
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.69683529
8Tryptophan metabolism_Homo sapiens_hsa003802.54863255
9Fatty acid degradation_Homo sapiens_hsa000712.48526210
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42054385
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.36440335
12Staphylococcus aureus infection_Homo sapiens_hsa051502.27843035
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25483580
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23133891
15Butanoate metabolism_Homo sapiens_hsa006502.11338571
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09258903
17Histidine metabolism_Homo sapiens_hsa003402.04202831
18Peroxisome_Homo sapiens_hsa041462.01873550
19PPAR signaling pathway_Homo sapiens_hsa033202.00039186
20Propanoate metabolism_Homo sapiens_hsa006401.94272187
21Fatty acid metabolism_Homo sapiens_hsa012121.88034910
22Chemical carcinogenesis_Homo sapiens_hsa052041.82777162
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79985267
24Caffeine metabolism_Homo sapiens_hsa002321.77862178
25beta-Alanine metabolism_Homo sapiens_hsa004101.71264427
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.70207322
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63038585
28Bile secretion_Homo sapiens_hsa049761.58571511
29Sulfur metabolism_Homo sapiens_hsa009201.53682803
30Retinol metabolism_Homo sapiens_hsa008301.51767514
31Fatty acid elongation_Homo sapiens_hsa000621.48591162
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48332479
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.44714556
34Fat digestion and absorption_Homo sapiens_hsa049751.43694963
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42234137
36ABC transporters_Homo sapiens_hsa020101.40574414
37Phenylalanine metabolism_Homo sapiens_hsa003601.40028918
38Selenocompound metabolism_Homo sapiens_hsa004501.36275977
39Starch and sucrose metabolism_Homo sapiens_hsa005001.31235870
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31203706
41Steroid biosynthesis_Homo sapiens_hsa001001.29534266
42Pyruvate metabolism_Homo sapiens_hsa006201.26301476
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.22709000
44Tyrosine metabolism_Homo sapiens_hsa003501.21586618
45Vitamin digestion and absorption_Homo sapiens_hsa049771.19374950
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13722154
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13317632
48Folate biosynthesis_Homo sapiens_hsa007901.12289980
49Arginine and proline metabolism_Homo sapiens_hsa003301.02417713
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97001308
51Carbon metabolism_Homo sapiens_hsa012000.94274347
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.91440041
53Biosynthesis of amino acids_Homo sapiens_hsa012300.90066994
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88016198
55Glycerolipid metabolism_Homo sapiens_hsa005610.83230840
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.82532988
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78103729
58Lysine degradation_Homo sapiens_hsa003100.73025528
59Vitamin B6 metabolism_Homo sapiens_hsa007500.72826379
60Asthma_Homo sapiens_hsa053100.69092595
61Glutathione metabolism_Homo sapiens_hsa004800.66227863
62Fatty acid biosynthesis_Homo sapiens_hsa000610.64299139
63Sulfur relay system_Homo sapiens_hsa041220.59735947
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55519599
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.53843890
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50676979
67Pentose phosphate pathway_Homo sapiens_hsa000300.45702793
68Lysosome_Homo sapiens_hsa041420.44914402
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44108392
70Prion diseases_Homo sapiens_hsa050200.43876936
71Allograft rejection_Homo sapiens_hsa053300.42288403
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.40330790
73Metabolic pathways_Homo sapiens_hsa011000.39492516
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38100323
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32424054
76Leishmaniasis_Homo sapiens_hsa051400.32222521
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.31275034
78Autoimmune thyroid disease_Homo sapiens_hsa053200.30886652
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30820362
80Other glycan degradation_Homo sapiens_hsa005110.29154137
81Insulin resistance_Homo sapiens_hsa049310.28981120
82Linoleic acid metabolism_Homo sapiens_hsa005910.28161682
83Graft-versus-host disease_Homo sapiens_hsa053320.27162715
84Galactose metabolism_Homo sapiens_hsa000520.26916525
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.24901489
86Amoebiasis_Homo sapiens_hsa051460.24499193
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24050701
88Renin secretion_Homo sapiens_hsa049240.23260774
89Pancreatic secretion_Homo sapiens_hsa049720.20398192
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19904675
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19427329
92Fructose and mannose metabolism_Homo sapiens_hsa000510.18595795
93One carbon pool by folate_Homo sapiens_hsa006700.16302199
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16251813
95Renin-angiotensin system_Homo sapiens_hsa046140.16246127
96Mineral absorption_Homo sapiens_hsa049780.14659327
97Type I diabetes mellitus_Homo sapiens_hsa049400.14312688
98Tuberculosis_Homo sapiens_hsa051520.12121120
99TNF signaling pathway_Homo sapiens_hsa046680.11224107
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10702054
101Toxoplasmosis_Homo sapiens_hsa051450.10500524
102Arachidonic acid metabolism_Homo sapiens_hsa005900.06901447
103African trypanosomiasis_Homo sapiens_hsa051430.06335645
104Pertussis_Homo sapiens_hsa051330.05879875
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04133732
106Ether lipid metabolism_Homo sapiens_hsa005650.03963712
107Malaria_Homo sapiens_hsa051440.03841176
108AMPK signaling pathway_Homo sapiens_hsa041520.02032555
109Ovarian steroidogenesis_Homo sapiens_hsa049130.01019766
110Glucagon signaling pathway_Homo sapiens_hsa049220.00509622
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1319163
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.1282685
113Sphingolipid metabolism_Homo sapiens_hsa00600-0.1177952
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0955735
115Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0852348
116Hepatitis C_Homo sapiens_hsa05160-0.0803161
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0619458
118Protein digestion and absorption_Homo sapiens_hsa04974-0.0289736

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