SEPSECS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.45241913
2L-phenylalanine catabolic process (GO:0006559)7.45241913
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.04126814
4L-phenylalanine metabolic process (GO:0006558)7.04126814
5aromatic amino acid family catabolic process (GO:0009074)6.48863851
6exogenous drug catabolic process (GO:0042738)5.68599065
7tryptophan catabolic process (GO:0006569)5.63391885
8indole-containing compound catabolic process (GO:0042436)5.63391885
9indolalkylamine catabolic process (GO:0046218)5.63391885
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.49027907
11tryptophan metabolic process (GO:0006568)5.42792503
12kynurenine metabolic process (GO:0070189)5.42718070
13bile acid biosynthetic process (GO:0006699)5.29765796
14glyoxylate metabolic process (GO:0046487)5.27616674
15alpha-linolenic acid metabolic process (GO:0036109)5.26283622
16peptidyl-glutamic acid carboxylation (GO:0017187)4.98718147
17protein carboxylation (GO:0018214)4.98718147
18urea metabolic process (GO:0019627)4.98171505
19urea cycle (GO:0000050)4.98171505
20high-density lipoprotein particle remodeling (GO:0034375)4.92196159
21sulfur amino acid catabolic process (GO:0000098)4.90058552
22cysteine metabolic process (GO:0006534)4.83604114
23negative regulation of fibrinolysis (GO:0051918)4.75429112
24regulation of fibrinolysis (GO:0051917)4.71933725
25aromatic amino acid family metabolic process (GO:0009072)4.70319271
26bile acid metabolic process (GO:0008206)4.69749977
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.64675876
28tyrosine metabolic process (GO:0006570)4.63643875
29complement activation, alternative pathway (GO:0006957)4.60729084
30nitrogen cycle metabolic process (GO:0071941)4.58516454
31serine family amino acid catabolic process (GO:0009071)4.58035381
32regulation of protein activation cascade (GO:2000257)4.52206139
33lysine catabolic process (GO:0006554)4.51968369
34lysine metabolic process (GO:0006553)4.51968369
35acylglycerol homeostasis (GO:0055090)4.50707324
36triglyceride homeostasis (GO:0070328)4.50707324
37homocysteine metabolic process (GO:0050667)4.43292487
38epoxygenase P450 pathway (GO:0019373)4.43087945
39reverse cholesterol transport (GO:0043691)4.37899039
40cellular ketone body metabolic process (GO:0046950)4.31164320
41regulation of cholesterol esterification (GO:0010872)4.31082214
42phospholipid efflux (GO:0033700)4.26724660
43regulation of triglyceride catabolic process (GO:0010896)4.23794653
44alpha-amino acid catabolic process (GO:1901606)4.23001380
45bile acid and bile salt transport (GO:0015721)4.22787693
46protein-lipid complex remodeling (GO:0034368)4.20561883
47macromolecular complex remodeling (GO:0034367)4.20561883
48plasma lipoprotein particle remodeling (GO:0034369)4.20561883
49S-adenosylmethionine metabolic process (GO:0046500)4.20554777
50regulation of complement activation (GO:0030449)4.19479485
51indolalkylamine metabolic process (GO:0006586)4.18475517
52amino-acid betaine metabolic process (GO:0006577)4.14339747
53negative regulation of cholesterol transport (GO:0032375)4.02746543
54negative regulation of sterol transport (GO:0032372)4.02746543
55plasma lipoprotein particle clearance (GO:0034381)3.96767924
56cellular amino acid catabolic process (GO:0009063)3.93695057
57imidazole-containing compound metabolic process (GO:0052803)3.90346625
58coenzyme catabolic process (GO:0009109)3.90201195
59intestinal cholesterol absorption (GO:0030299)3.89863430
60cholesterol efflux (GO:0033344)3.86236393
61glycine metabolic process (GO:0006544)3.83690224
62cellular biogenic amine catabolic process (GO:0042402)3.80824576
63amine catabolic process (GO:0009310)3.80824576
64regulation of cholesterol homeostasis (GO:2000188)3.78791495
65glutamate metabolic process (GO:0006536)3.74598699
66uronic acid metabolic process (GO:0006063)3.74256096
67glucuronate metabolic process (GO:0019585)3.74256096
68drug catabolic process (GO:0042737)3.74249172
69drug transmembrane transport (GO:0006855)3.74166657
70cellular modified amino acid catabolic process (GO:0042219)3.72005464
71benzene-containing compound metabolic process (GO:0042537)3.71846558
72ketone body metabolic process (GO:1902224)3.71743724
73phospholipid homeostasis (GO:0055091)3.71302180
74omega-hydroxylase P450 pathway (GO:0097267)3.68518890
75plasma lipoprotein particle assembly (GO:0034377)3.68259023
76serine family amino acid metabolic process (GO:0009069)3.66872813
77regulation of bile acid biosynthetic process (GO:0070857)3.63239701
78cellular glucuronidation (GO:0052695)3.57543597
79synapsis (GO:0007129)3.57379156
80oxidative demethylation (GO:0070989)3.56856173
81organic acid catabolic process (GO:0016054)3.53281981
82carboxylic acid catabolic process (GO:0046395)3.53281981
83short-chain fatty acid metabolic process (GO:0046459)3.49767298
84dicarboxylic acid biosynthetic process (GO:0043650)3.49700719
85low-density lipoprotein particle remodeling (GO:0034374)3.48608803
86fatty acid beta-oxidation (GO:0006635)3.48539856
87lipoprotein metabolic process (GO:0042157)3.47662586
88fatty acid oxidation (GO:0019395)3.46421629
89valine metabolic process (GO:0006573)3.46038655
90cholesterol homeostasis (GO:0042632)3.41700657
91positive regulation of triglyceride lipase activity (GO:0061365)3.39533668
92positive regulation of lipoprotein lipase activity (GO:0051006)3.39533668
93lipid oxidation (GO:0034440)3.38632199
94cilium or flagellum-dependent cell motility (GO:0001539)3.38233008
95monocarboxylic acid catabolic process (GO:0072329)3.38163516
96sterol homeostasis (GO:0055092)3.37094231
972-oxoglutarate metabolic process (GO:0006103)3.35053576
98positive regulation of lipid catabolic process (GO:0050996)3.34923925
99fucose catabolic process (GO:0019317)3.34224970
100L-fucose metabolic process (GO:0042354)3.34224970
101L-fucose catabolic process (GO:0042355)3.34224970
102fibrinolysis (GO:0042730)3.33879569
103urate metabolic process (GO:0046415)3.33452910
104fatty acid catabolic process (GO:0009062)3.32953212
105cofactor catabolic process (GO:0051187)3.32147885
106ethanol oxidation (GO:0006069)3.31760637
107plasma lipoprotein particle organization (GO:0071827)3.31255481
108serine family amino acid biosynthetic process (GO:0009070)3.30738922
109blood coagulation, intrinsic pathway (GO:0007597)3.30603360
110very-low-density lipoprotein particle assembly (GO:0034379)3.30317600
111drug metabolic process (GO:0017144)3.29977367
112negative regulation of lipase activity (GO:0060192)3.28907111
113response to pheromone (GO:0019236)3.15198224
114heme transport (GO:0015886)3.09524051
115cellular response to ethanol (GO:0071361)3.05342615
116L-methionine salvage (GO:0071267)3.03802797
117L-methionine biosynthetic process (GO:0071265)3.03802797
118amino acid salvage (GO:0043102)3.03802797
119alkaloid metabolic process (GO:0009820)2.95545206
120epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83087988
121piRNA metabolic process (GO:0034587)2.82737931
122organic cation transport (GO:0015695)2.82424387
123interkinetic nuclear migration (GO:0022027)2.79118026
124protein K11-linked deubiquitination (GO:0035871)2.78500446
125neural tube formation (GO:0001841)2.76683029
126fat-soluble vitamin biosynthetic process (GO:0042362)2.71688849
127ethanol metabolic process (GO:0006067)2.59366476
128rRNA catabolic process (GO:0016075)2.55388782
129methionine biosynthetic process (GO:0009086)2.54947370
130sodium-independent organic anion transport (GO:0043252)2.54318409
131RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.52244061
132detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50464294
133flavonoid metabolic process (GO:0009812)2.50213066
134indole-containing compound metabolic process (GO:0042430)2.49111474
135drug transport (GO:0015893)2.45490290
136negative regulation of DNA-dependent DNA replication (GO:2000104)2.44407566
137positive regulation of fatty acid transport (GO:2000193)2.42883120
138L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40523058
139reciprocal DNA recombination (GO:0035825)2.40137106
140reciprocal meiotic recombination (GO:0007131)2.40137106
141regulation of protein polyubiquitination (GO:1902914)2.37366762
142regulation of memory T cell differentiation (GO:0043380)2.36552811
143negative regulation of protein activation cascade (GO:2000258)2.36159355
144protein localization to Golgi apparatus (GO:0034067)2.35338081
145establishment of protein localization to Golgi (GO:0072600)2.32944855
146dopamine transport (GO:0015872)2.32794119
147disruption of cells of other organism (GO:0044364)2.32766828
148killing of cells of other organism (GO:0031640)2.32766828
149detection of light stimulus involved in visual perception (GO:0050908)2.31842114
150detection of light stimulus involved in sensory perception (GO:0050962)2.31842114
151regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.28613434
152phenylpropanoid metabolic process (GO:0009698)2.28268911
153C4-dicarboxylate transport (GO:0015740)2.28166518
154branched-chain amino acid catabolic process (GO:0009083)2.27988352
155monoubiquitinated protein deubiquitination (GO:0035520)2.27268246
156xenobiotic metabolic process (GO:0006805)2.26842894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.79363576
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.69281054
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.33148041
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.21015364
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.92327149
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.82152334
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.31359938
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.97821412
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74643507
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.28916252
11ZNF274_21170338_ChIP-Seq_K562_Hela3.12363600
12GATA1_22025678_ChIP-Seq_K562_Human2.87359555
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86150448
14IGF1R_20145208_ChIP-Seq_DFB_Human2.62264969
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.57242585
16VDR_22108803_ChIP-Seq_LS180_Human2.53379892
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.41844905
18TAF15_26573619_Chip-Seq_HEK293_Human2.38372820
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.35179442
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27527075
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18121880
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14979625
23FUS_26573619_Chip-Seq_HEK293_Human2.07543894
24ER_23166858_ChIP-Seq_MCF-7_Human2.01169565
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.7172754
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95283063
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.95220471
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94618051
29GBX2_23144817_ChIP-Seq_PC3_Human1.94291287
30EWS_26573619_Chip-Seq_HEK293_Human1.93902740
31CLOCK_20551151_ChIP-Seq_293T_Human1.89544618
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80681182
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78387865
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.70937108
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69726888
36P300_19829295_ChIP-Seq_ESCs_Human1.65607014
37* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.55926749
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.55822458
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55695471
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54776232
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54127169
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53563528
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51002384
44CBP_20019798_ChIP-Seq_JUKART_Human1.50779983
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50779983
46* HNF4A_19822575_ChIP-Seq_HepG2_Human1.48181384
47* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48008125
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47618423
49RUNX_20019798_ChIP-Seq_JUKART_Human1.47140841
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46283899
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46095171
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.45855142
53STAT3_23295773_ChIP-Seq_U87_Human1.45329315
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.43267646
55HTT_18923047_ChIP-ChIP_STHdh_Human1.42757901
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41639370
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40905216
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38930620
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38099010
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.34897957
61SOX2_19829295_ChIP-Seq_ESCs_Human1.33670299
62NANOG_19829295_ChIP-Seq_ESCs_Human1.33670299
63* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31190806
64TCF4_23295773_ChIP-Seq_U87_Human1.30575762
65IRF1_19129219_ChIP-ChIP_H3396_Human1.29138234
66ELK1_19687146_ChIP-ChIP_HELA_Human1.25560142
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25105885
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24957836
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23729729
70AR_25329375_ChIP-Seq_VCAP_Human1.23323309
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23233832
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.23158183
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23158183
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.22719441
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21910692
76TCF4_22108803_ChIP-Seq_LS180_Human1.20859085
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.20854709
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.19363989
79GATA4_25053715_ChIP-Seq_YYC3_Human1.18971792
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.18343030
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17332842
82VDR_23849224_ChIP-Seq_CD4+_Human1.16753496
83P53_22387025_ChIP-Seq_ESCs_Mouse1.16668881
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14294598
85SMAD4_21799915_ChIP-Seq_A2780_Human1.13681376
86MYB_26560356_Chip-Seq_TH2_Human1.12379765
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12261546
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11868042
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11141711
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10866690
91TP53_22573176_ChIP-Seq_HFKS_Human1.10850760
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10693715
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.09270700
94OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08765509
95GATA3_27048872_Chip-Seq_THYMUS_Human1.08571867
96IRF8_21731497_ChIP-ChIP_J774_Mouse1.08470629
97AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08188624
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07686584
99* IRF8_27001747_Chip-Seq_BMDM_Mouse1.06885156
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.06823210
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06752514
102ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06502230
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06311719
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.06274360
105OCT4_18555785_Chip-Seq_ESCs_Mouse1.04093626
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.03837405
107RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01781465
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95399537
109FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93610121
110FOXA1_25552417_ChIP-Seq_VCAP_Human0.93184082
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89124626
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87715535
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86969968
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84331168
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79194645
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77273342
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73073491
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71906025
119RARA_24833708_ChIP-Seq_LIVER_Mouse0.71548025
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69834235
121BCAT_22108803_ChIP-Seq_LS180_Human0.69594088
122AR_20517297_ChIP-Seq_VCAP_Human0.69057273
123GATA1_19941826_ChIP-Seq_K562_Human0.68842683
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68035133
125RARB_24833708_ChIP-Seq_LIVER_Mouse0.67151317
126GATA6_25053715_ChIP-Seq_YYC3_Human0.65858889
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65054471
128ERG_20517297_ChIP-Seq_VCAP_Human0.63380207
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62145782
130NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62145782
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.61463222
132* GATA3_24758297_ChIP-Seq_MCF-7_Human0.61020102
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.60252581
134* CDX2_22108803_ChIP-Seq_LS180_Human0.59259460
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58733608
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.56722059
137CBP_21632823_ChIP-Seq_H3396_Human0.56666333
138GATA2_19941826_ChIP-Seq_K562_Human0.56087343
139SOX2_20726797_ChIP-Seq_SW620_Human0.54134286
140PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.53686044
141AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.52913442
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.52616500
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.52530342
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.51749478
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51700460
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.51397287
147ELF1_17652178_ChIP-ChIP_JURKAT_Human0.51256554
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.50526421
149ESET_19884257_ChIP-Seq_ESCs_Mouse0.49972040
150AUTS2_25519132_ChIP-Seq_293T-REX_Human0.49343066
151CEBPB_22108803_ChIP-Seq_LS180_Human0.49075526
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.48534770
153LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.47689022
154RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.47359052
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.47352221
156P53_21459846_ChIP-Seq_SAOS-2_Human0.47222523
157STAT1_17558387_ChIP-Seq_HELA_Human0.45452073
158CRX_20693478_ChIP-Seq_RETINA_Mouse0.44628740
159* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44561746
160ESR1_15608294_ChIP-ChIP_MCF-7_Human0.44237810
161THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.43343079
162EZH2_27294783_Chip-Seq_NPCs_Mouse0.43219772
163PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.43160637
164LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.43061275
165GATA3_26560356_Chip-Seq_TH2_Human0.42769931
166EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.42290188
167PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42237112
168BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.41628882
169OCT4_21477851_ChIP-Seq_ESCs_Mouse0.41620942
170GATA3_26560356_Chip-Seq_TH1_Human0.41603276
171TBX20_22328084_ChIP-Seq_HEART_Mouse0.40766009
172TBX20_22080862_ChIP-Seq_HEART_Mouse0.40766009
173MYC_19915707_ChIP-ChIP_AK7_Human0.40581331
174PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40451492
175NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.40430092
176BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.40400638
177ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.40298394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.75430446
2MP0005360_urolithiasis6.76431511
3MP0005365_abnormal_bile_salt5.92881482
4MP0005085_abnormal_gallbladder_physiolo5.81767172
5MP0008875_abnormal_xenobiotic_pharmacok4.40691560
6MP0003252_abnormal_bile_duct4.07573287
7MP0003806_abnormal_nucleotide_metabolis3.90957512
8MP0003195_calcinosis3.39088184
9MP0010329_abnormal_lipoprotein_level3.32135819
10MP0004147_increased_porphyrin_level3.20780085
11MP0008877_abnormal_DNA_methylation2.90199095
12MP0001666_abnormal_nutrient_absorption2.77231086
13MP0002138_abnormal_hepatobiliary_system2.76633828
14MP0009840_abnormal_foam_cell2.72953499
15MP0005083_abnormal_biliary_tract2.69431208
16MP0005332_abnormal_amino_acid2.57303336
17MP0000609_abnormal_liver_physiology2.18206914
18MP0002118_abnormal_lipid_homeostasis2.16978658
19MP0003868_abnormal_feces_composition2.11452115
20MP0004019_abnormal_vitamin_homeostasis2.00986312
21MP0002396_abnormal_hematopoietic_system1.98495807
22MP0003191_abnormal_cellular_cholesterol1.95245041
23MP0001835_abnormal_antigen_presentation1.94836642
24MP0008057_abnormal_DNA_replication1.87891405
25MP0000569_abnormal_digit_pigmentation1.71344303
26MP0005319_abnormal_enzyme/_coenzyme1.70025710
27MP0005220_abnormal_exocrine_pancreas1.70016068
28MP0002254_reproductive_system_inflammat1.67529168
29MP0001873_stomach_inflammation1.63372162
30MP0000685_abnormal_immune_system1.63028154
31MP0009643_abnormal_urine_homeostasis1.61592798
32MP0004043_abnormal_pH_regulation1.59897450
33MP0001764_abnormal_homeostasis1.57780016
34MP0003283_abnormal_digestive_organ1.52694738
35MP0001800_abnormal_humoral_immune1.48548737
36MP0002078_abnormal_glucose_homeostasis1.44789058
37MP0001944_abnormal_pancreas_morphology1.40365640
38MP0005671_abnormal_response_to1.36034506
39MP0005584_abnormal_enzyme/coenzyme_acti1.35637328
40MP0002693_abnormal_pancreas_physiology1.33795410
41MP0005551_abnormal_eye_electrophysiolog1.29804055
42MP0002877_abnormal_melanocyte_morpholog1.29604344
43MP0009697_abnormal_copulation1.29037037
44MP0006292_abnormal_olfactory_placode1.25809030
45MP0009785_altered_susceptibility_to1.24095568
46MP0005636_abnormal_mineral_homeostasis1.20814888
47MP0005408_hypopigmentation1.18280161
48MP0008872_abnormal_physiological_respon1.17139360
49MP0000598_abnormal_liver_morphology1.16951254
50MP0005075_abnormal_melanosome_morpholog1.16919610
51MP0002876_abnormal_thyroid_physiology1.16873576
52MP0002148_abnormal_hypersensitivity_rea1.15936481
53MP0002837_dystrophic_cardiac_calcinosis1.15759417
54MP0000372_irregular_coat_pigmentation1.15753337
55MP0004142_abnormal_muscle_tone1.12557321
56MP0009780_abnormal_chondrocyte_physiolo1.12481897
57MP0003186_abnormal_redox_activity1.12043428
58MP0008058_abnormal_DNA_repair1.11881108
59MP0010155_abnormal_intestine_physiology1.09787182
60MP0002723_abnormal_immune_serum1.09582764
61MP0002009_preneoplasia1.08854470
62MP0003718_maternal_effect1.05132886
63MP0005174_abnormal_tail_pigmentation1.05130340
64MP0001986_abnormal_taste_sensitivity1.05051665
65MP0005310_abnormal_salivary_gland1.04566356
66MP0005084_abnormal_gallbladder_morpholo1.03602440
67MP0002928_abnormal_bile_duct1.01282820
68MP0005000_abnormal_immune_tolerance1.00725289
69MP0005535_abnormal_body_temperature0.97466422
70MP0005379_endocrine/exocrine_gland_phen0.97427299
71MP0009642_abnormal_blood_homeostasis0.97404410
72MP0005670_abnormal_white_adipose0.96992885
73MP0001756_abnormal_urination0.96566011
74MP0003656_abnormal_erythrocyte_physiolo0.96124951
75MP0006036_abnormal_mitochondrial_physio0.93302569
76MP0005387_immune_system_phenotype0.93199145
77MP0001790_abnormal_immune_system0.93199145
78MP0005410_abnormal_fertilization0.93191250
79MP0005451_abnormal_body_composition0.92489362
80MP0004264_abnormal_extraembryonic_tissu0.91371495
81MP0005645_abnormal_hypothalamus_physiol0.91248834
82MP0002452_abnormal_antigen_presenting0.90842561
83MP0000689_abnormal_spleen_morphology0.89895729
84MP0000015_abnormal_ear_pigmentation0.89568838
85MP0001919_abnormal_reproductive_system0.89378397
86MP0000427_abnormal_hair_cycle0.89304452
87MP0002166_altered_tumor_susceptibility0.89024204
88MP0008995_early_reproductive_senescence0.88519399
89MP0005058_abnormal_lysosome_morphology0.88332404
90MP0002420_abnormal_adaptive_immunity0.87368337
91MP0003943_abnormal_hepatobiliary_system0.86862156
92MP0001929_abnormal_gametogenesis0.86775977
93MP0001819_abnormal_immune_cell0.86507454
94MP0003763_abnormal_thymus_physiology0.85392871
95MP0002398_abnormal_bone_marrow0.85175774
96MP0009763_increased_sensitivity_to0.84770339
97MP0002006_tumorigenesis0.84216280
98MP0003705_abnormal_hypodermis_morpholog0.82796410
99MP0008469_abnormal_protein_level0.81982309
100MP0002971_abnormal_brown_adipose0.81844349
101MP0000716_abnormal_immune_system0.80995050
102MP0003300_gastrointestinal_ulcer0.80935242
103MP0005025_abnormal_response_to0.80601565
104MP0005334_abnormal_fat_pad0.80220896
105MP0005647_abnormal_sex_gland0.79808289
106MP0002102_abnormal_ear_morphology0.79618464
107MP0005397_hematopoietic_system_phenotyp0.79595423
108MP0001545_abnormal_hematopoietic_system0.79595423
109MP0004885_abnormal_endolymph0.79165165
110MP0000604_amyloidosis0.78949001
111MP0009764_decreased_sensitivity_to0.78812220
112MP0003953_abnormal_hormone_level0.77295406
113MP0005448_abnormal_energy_balance0.76690580
114MP0001661_extended_life_span0.75486527
115MP0003646_muscle_fatigue0.72127369
116MP0002419_abnormal_innate_immunity0.72086844
117MP0002909_abnormal_adrenal_gland0.71120188
118MP0002405_respiratory_system_inflammati0.70742361
119MP0006082_CNS_inflammation0.70527783
120MP0000013_abnormal_adipose_tissue0.70177317
121MP0003787_abnormal_imprinting0.70030427
122MP0005389_reproductive_system_phenotype0.69686316
123MP0001765_abnormal_ion_homeostasis0.69154198
124MP0001501_abnormal_sleep_pattern0.69072245
125MP0001188_hyperpigmentation0.68536274
126MP0002132_abnormal_respiratory_system0.68373955
127MP0005376_homeostasis/metabolism_phenot0.67441905
128MP0010386_abnormal_urinary_bladder0.67124641
129MP0000639_abnormal_adrenal_gland0.63692870
130MP0004130_abnormal_muscle_cell0.63118061
131MP0009765_abnormal_xenobiotic_induced0.62829583
132MP0005266_abnormal_metabolism0.61981381
133MP0005666_abnormal_adipose_tissue0.61153893
134MP0004782_abnormal_surfactant_physiolog0.56296771
135MP0002136_abnormal_kidney_physiology0.54253957
136MP0003011_delayed_dark_adaptation0.53036730
137MP0004185_abnormal_adipocyte_glucose0.51717353
138MP0010368_abnormal_lymphatic_system0.49066050
139MP0000230_abnormal_systemic_arterial0.48367387
140MP0009672_abnormal_birth_weight0.47808010
141MP0003183_abnormal_peptide_metabolism0.45155130
142MP0003959_abnormal_lean_body0.44930728
143MP0002970_abnormal_white_adipose0.43240754
144MP0003724_increased_susceptibility_to0.42066178
145MP0002896_abnormal_bone_mineralization0.40972561
146MP0006035_abnormal_mitochondrial_morpho0.40835703
147MP0005395_other_phenotype0.40744091
148MP0008961_abnormal_basal_metabolism0.39534059
149MP0000538_abnormal_urinary_bladder0.39470008
150MP0005464_abnormal_platelet_physiology0.38611057
151MP0003890_abnormal_embryonic-extraembry0.38325121
152MP0003638_abnormal_response/metabolism_0.37631378
153MP0005375_adipose_tissue_phenotype0.37583749
154MP0000613_abnormal_salivary_gland0.37371371
155MP0002168_other_aberrant_phenotype0.36091092
156MP0005646_abnormal_pituitary_gland0.35335331
157MP0001881_abnormal_mammary_gland0.35132700
158MP0005248_abnormal_Harderian_gland0.33672513
159MP0000003_abnormal_adipose_tissue0.33142991
160MP0001845_abnormal_inflammatory_respons0.32944266

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.43771960
2Intrahepatic cholestasis (HP:0001406)6.87656306
3Deep venous thrombosis (HP:0002625)5.98762095
4Hypoglycemic coma (HP:0001325)5.90302943
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.84222120
6Prolonged partial thromboplastin time (HP:0003645)5.81171161
7Xanthomatosis (HP:0000991)5.47739637
8Hypobetalipoproteinemia (HP:0003563)5.28224634
9Hypoglycemic seizures (HP:0002173)4.83396333
10Hyperinsulinemic hypoglycemia (HP:0000825)4.60912496
11Ketosis (HP:0001946)4.60689897
12Abnormality of the common coagulation pathway (HP:0010990)4.34095866
13Hyperlipoproteinemia (HP:0010980)4.33435381
14Abnormality of the intrinsic pathway (HP:0010989)4.30876964
15Ketoacidosis (HP:0001993)4.28332689
16Complement deficiency (HP:0004431)4.16689976
17Conjugated hyperbilirubinemia (HP:0002908)4.16050630
18Fat malabsorption (HP:0002630)4.08344040
19Epidermoid cyst (HP:0200040)4.05206979
20Hyperglycinemia (HP:0002154)3.98766888
21Joint hemorrhage (HP:0005261)3.97239369
22Hypolipoproteinemia (HP:0010981)3.97093695
23Hyperammonemia (HP:0001987)3.88891980
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.86833310
25Symptomatic seizures (HP:0011145)3.82024380
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.77001264
27Hyperglycinuria (HP:0003108)3.73975556
28Abnormality of methionine metabolism (HP:0010901)3.69122515
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.60633853
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.58735471
31Abnormality of glycine metabolism (HP:0010895)3.52131276
32Abnormality of serine family amino acid metabolism (HP:0010894)3.52131276
33Hyperglycemia (HP:0003074)3.51015316
34Hypoalphalipoproteinemia (HP:0003233)3.46011482
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39311542
36Generalized aminoaciduria (HP:0002909)3.39113149
37Late onset (HP:0003584)3.36064904
38Abnormality of fatty-acid metabolism (HP:0004359)3.32905297
39Hyperbilirubinemia (HP:0002904)3.28442510
40Abnormality of the renal cortex (HP:0011035)3.09450096
41Abnormality of purine metabolism (HP:0004352)3.04658765
42Abnormality of complement system (HP:0005339)2.98592990
43Skin nodule (HP:0200036)2.97286034
44Chronic hepatic failure (HP:0100626)2.96879607
45Abnormality of nucleobase metabolism (HP:0010932)2.96507685
46Hypercholesterolemia (HP:0003124)2.95980979
47Pancreatic cysts (HP:0001737)2.92211617
48Gout (HP:0001997)2.90556486
49Steatorrhea (HP:0002570)2.88389947
50Abnormality of the pancreatic islet cells (HP:0006476)2.85866830
51Abnormality of endocrine pancreas physiology (HP:0012093)2.85866830
52Abnormality of B cell number (HP:0010975)2.81647846
53Abnormality of pyrimidine metabolism (HP:0004353)2.80205527
54Myocardial infarction (HP:0001658)2.72937389
55Panhypogammaglobulinemia (HP:0003139)2.71669371
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64619601
57Dicarboxylic aciduria (HP:0003215)2.64619601
58Pancreatic islet-cell hyperplasia (HP:0004510)2.64368527
59Stomach cancer (HP:0012126)2.63831221
60Hepatocellular carcinoma (HP:0001402)2.63422176
61Abnormality of serum amino acid levels (HP:0003112)2.63263834
62Metabolic acidosis (HP:0001942)2.62919051
63Attenuation of retinal blood vessels (HP:0007843)2.62420101
64Delayed CNS myelination (HP:0002188)2.58510603
65Medial flaring of the eyebrow (HP:0010747)2.58287273
66Thyroiditis (HP:0100646)2.56138883
67Abnormal biliary tract physiology (HP:0012439)2.54595779
68Bile duct proliferation (HP:0001408)2.54595779
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.53428694
70B lymphocytopenia (HP:0010976)2.47638303
71Limb hypertonia (HP:0002509)2.47567978
72Chronic sinusitis (HP:0011109)2.46398409
73Fair hair (HP:0002286)2.45732943
74Pancreatic fibrosis (HP:0100732)2.43359495
75Stomatitis (HP:0010280)2.39660402
76* Irritability (HP:0000737)2.38381251
77Hypochromic microcytic anemia (HP:0004840)2.36055693
78Abnormal gallbladder morphology (HP:0012437)2.35068888
79Lethargy (HP:0001254)2.34246685
80Enlarged kidneys (HP:0000105)2.33016979
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.32329476
82Absent/shortened dynein arms (HP:0200106)2.32329476
83Severe combined immunodeficiency (HP:0004430)2.30812681
84Spontaneous abortion (HP:0005268)2.29588956
853-Methylglutaconic aciduria (HP:0003535)2.28508550
86Acanthocytosis (HP:0001927)2.26570583
87Hypothermia (HP:0002045)2.26279408
88Molar tooth sign on MRI (HP:0002419)2.23641629
89Abnormality of midbrain morphology (HP:0002418)2.23641629
90Congenital stationary night blindness (HP:0007642)2.23357903
91Mitral stenosis (HP:0001718)2.22192944
92Nephronophthisis (HP:0000090)2.21389750
93Abnormal enzyme/coenzyme activity (HP:0012379)2.20993297
94Pancreatitis (HP:0001733)2.18213327
95Renal cortical cysts (HP:0000803)2.16993454
96True hermaphroditism (HP:0010459)2.14941591
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13825048
98Abnormality of alanine metabolism (HP:0010916)2.13825048
99Hyperalaninemia (HP:0003348)2.13825048
100Abnormality of urine glucose concentration (HP:0011016)2.13214795
101Glycosuria (HP:0003076)2.13214795
102Abnormality of T cell number (HP:0011839)2.12971874
103Proximal tubulopathy (HP:0000114)2.12271949
104Congenital primary aphakia (HP:0007707)2.11230737
105Insulin-resistant diabetes mellitus (HP:0000831)2.10571289
106Abolished electroretinogram (ERG) (HP:0000550)2.10258151
107Elevated alkaline phosphatase (HP:0003155)2.08836284
108Insulin resistance (HP:0000855)2.08658269
109Brushfield spots (HP:0001088)2.06939556
110Abnormal respiratory motile cilium morphology (HP:0005938)2.06151539
111Abnormal respiratory epithelium morphology (HP:0012253)2.06151539
112Vascular calcification (HP:0004934)2.04585069
113Nephrogenic diabetes insipidus (HP:0009806)2.04071228
114T lymphocytopenia (HP:0005403)2.01963003
115Alkalosis (HP:0001948)2.01658032
116Abnormality of proline metabolism (HP:0010907)2.01185304
117Hydroxyprolinuria (HP:0003080)2.01185304
118Abnormality of alkaline phosphatase activity (HP:0004379)2.00682659
119Abnormality of the renal medulla (HP:0100957)1.99966181
120Rickets (HP:0002748)1.99896445
121Acute hepatic failure (HP:0006554)1.99894525
122Cerebral edema (HP:0002181)1.97141739
123Decreased central vision (HP:0007663)1.96877158
124Gait imbalance (HP:0002141)1.96859472
125Malnutrition (HP:0004395)1.96501680
126Progressive inability to walk (HP:0002505)1.93886767
127Abnormal ciliary motility (HP:0012262)1.92917916
128Abnormality of macular pigmentation (HP:0008002)1.92654937
129Protuberant abdomen (HP:0001538)1.91897273
130Abnormal rod and cone electroretinograms (HP:0008323)1.91475368
131Systemic lupus erythematosus (HP:0002725)1.90064102
132Abnormality of the gallbladder (HP:0005264)1.89680426
133Abnormality of T cells (HP:0002843)1.89227236
134Abnormality of eosinophils (HP:0001879)1.89185969
135Cholelithiasis (HP:0001081)1.88953810
136Vomiting (HP:0002013)1.88870866
137Sensorimotor neuropathy (HP:0007141)1.88851444
138IgG deficiency (HP:0004315)1.88637065
139Menorrhagia (HP:0000132)1.88548137
140Central scotoma (HP:0000603)1.88329647
141Constricted visual fields (HP:0001133)1.88293791
142Encephalitis (HP:0002383)1.88174968
143Esophageal varix (HP:0002040)1.87586786
144Spastic diplegia (HP:0001264)1.87278688
145Neoplasm of the tracheobronchial system (HP:0100552)1.86118370
146Alveolar cell carcinoma (HP:0006519)1.85346284
147Gingival bleeding (HP:0000225)1.85232305
148Death in childhood (HP:0003819)1.84721643
149Keratoconjunctivitis (HP:0001096)1.82824399
150Poikilocytosis (HP:0004447)1.82705713
151Increased purine levels (HP:0004368)1.81917198
152Hyperuricemia (HP:0002149)1.81917198
153Glomerulonephritis (HP:0000099)1.81737962
154Optic neuritis (HP:0100653)1.81455396
155Retrobulbar optic neuritis (HP:0100654)1.81455396
156Poor coordination (HP:0002370)1.80707429
157Hypoproteinemia (HP:0003075)1.80009575
158Chronic otitis media (HP:0000389)1.79715726
159Chronic mucocutaneous candidiasis (HP:0002728)1.79707005
160Recurrent cutaneous fungal infections (HP:0011370)1.79707005
161Abnormality of vitamin B metabolism (HP:0004340)1.79695914
162Hypophosphatemia (HP:0002148)1.79615771
163Abnormality of T cell physiology (HP:0011840)1.77944024
164Hyperventilation (HP:0002883)1.77453287
165Abnormality of vitamin metabolism (HP:0100508)1.77431123
166Generalized hypopigmentation of hair (HP:0011358)1.76387065
167Abnormality of chromosome stability (HP:0003220)1.75443569
168Myositis (HP:0100614)1.74400342
169Combined immunodeficiency (HP:0005387)1.73910771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.24897051
2BCKDK4.66376691
3TAOK34.00933437
4ACVR1B3.43703822
5ERN13.43671753
6SIK13.16341756
7ZAK3.05972890
8FGFR43.03551266
9FLT32.91864592
10MAPK152.60321686
11FRK2.50971582
12PASK2.40787039
13MAP4K22.33730866
14TRIB32.24320250
15CAMKK22.13073049
16MAP3K31.97088135
17BMPR1B1.96237626
18ADRBK21.91971408
19TXK1.88084866
20IRAK31.79900755
21PTK61.72177653
22PIK3CG1.58933630
23BRSK21.53482263
24HIPK21.51974575
25ERBB41.49653871
26PKN21.48108065
27MAP3K41.45187518
28MAP3K141.41266417
29TYK21.40979180
30SGK21.40222394
31EPHA31.37644719
32STK391.36811529
33MST1R1.35902909
34AKT31.33544446
35MAPK131.30976615
36DYRK31.30861696
37TEC1.30547772
38MAP3K21.29988798
39STK38L1.27792103
40TAF11.26336496
41PLK41.25905321
42MAPK111.25202352
43JAK21.23905683
44NEK91.22857464
45WNK41.22416634
46SGK31.18935057
47MKNK21.16024475
48PRKAA21.15838330
49MAP2K31.14919769
50OXSR11.14368426
51SYK1.11701058
52MET1.11227598
53LATS11.09858390
54JAK11.05772477
55WNK31.03048188
56MKNK11.02824755
57BMPR21.02479194
58PIK3CA1.02007691
59MAP4K11.01993919
60BCR1.01871705
61SGK2230.97462605
62SGK4940.97462605
63EIF2AK30.95682868
64JAK30.94005264
65TRPM70.90801269
66MAP2K40.90774441
67DYRK1B0.89464554
68TGFBR10.89192346
69MAPKAPK30.86583948
70ERBB30.85185976
71PRKCH0.82719566
72TBK10.82207408
73PDK20.81569199
74TLK10.80132951
75IRAK10.76618986
76DAPK20.76438694
77PTK20.75157401
78MAP2K70.74903036
79GSK3A0.74188372
80LCK0.73011015
81MST40.71817849
82PRKAA10.71555378
83PRKD30.71483986
84MATK0.69979516
85CHUK0.68306437
86MARK30.66585182
87CSNK1G10.66041774
88SCYL20.63425024
89PRKACG0.62912168
90WEE10.62604582
91MAPKAPK50.62211323
92CAMK1D0.62199444
93BTK0.61997232
94VRK10.61934796
95PRKD20.61552625
96MAP3K10.61454959
97RET0.61428220
98KIT0.59690810
99MAP2K60.59563149
100LYN0.58558373
101PIM10.57678890
102PRKCE0.56009618
103NLK0.55656362
104GRK60.55540913
105EPHB10.54936290
106CSNK1G20.53586850
107PDGFRA0.53506829
108FGFR30.53263363
109GRK70.50661317
110MAP3K60.50252376
111CSNK1G30.48659628
112CSK0.48498115
113TNIK0.48211448
114ITK0.47599850
115STK30.47286385
116TRIM280.46408008
117MAP2K20.46307765
118MAP3K120.45769369
119HCK0.44283817
120GRK10.41564061
121MTOR0.41457659
122CSNK1A1L0.40713819
123IGF1R0.40125197
124CSNK1D0.37209859
125MAP3K100.36626662
126NUAK10.36382120
127ABL20.35621339
128BLK0.35461695
129EIF2AK20.34846448
130OBSCN0.32921732
131ADRBK10.32756007
132PRKCZ0.32720661
133RPS6KB10.32555706
134CAMKK10.32291710
135PLK20.32202742
136CDK60.31774421
137MAP3K70.31755802
138PAK30.31634856
139IRAK20.31533904
140NTRK10.29777458
141PDPK10.29500407
142ZAP700.28190454
143PINK10.28004471
144KDR0.27330032
145MAP2K10.27219575
146FER0.26481774
147PDK40.26050245
148PDK30.26050245
149IKBKE0.26037496
150FGFR20.25623367
151PRKCQ0.25605775
152MAPK30.25553176
153ERBB20.24890074
154CDC42BPA0.23785515
155BRD40.22508689
156BRAF0.21708795
157EGFR0.21413119
158IRAK40.20859539
159IKBKB0.19624679
160CAMK2G0.18228010
161CSF1R0.17785935

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.12622029
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.45380974
3Nitrogen metabolism_Homo sapiens_hsa009103.34333555
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10325418
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97392737
6Tryptophan metabolism_Homo sapiens_hsa003802.89652913
7Arginine biosynthesis_Homo sapiens_hsa002202.63892490
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.58038635
9Fatty acid degradation_Homo sapiens_hsa000712.50334357
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.48490582
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.36429490
12Complement and coagulation cascades_Homo sapiens_hsa046102.35916590
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31357525
14Butanoate metabolism_Homo sapiens_hsa006502.23758050
15Sulfur metabolism_Homo sapiens_hsa009202.19225960
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14969960
17Peroxisome_Homo sapiens_hsa041462.04947864
18Propanoate metabolism_Homo sapiens_hsa006401.93916873
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91290641
20* Selenocompound metabolism_Homo sapiens_hsa004501.90493928
21Non-homologous end-joining_Homo sapiens_hsa034501.87215830
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.85888755
23Histidine metabolism_Homo sapiens_hsa003401.84249803
24Fatty acid metabolism_Homo sapiens_hsa012121.80647650
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.77036103
26PPAR signaling pathway_Homo sapiens_hsa033201.69556207
27Folate biosynthesis_Homo sapiens_hsa007901.68274766
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.60570677
29Chemical carcinogenesis_Homo sapiens_hsa052041.59902293
30Caffeine metabolism_Homo sapiens_hsa002321.58723784
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57899434
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57837150
33Phenylalanine metabolism_Homo sapiens_hsa003601.54832421
34Asthma_Homo sapiens_hsa053101.53713689
35beta-Alanine metabolism_Homo sapiens_hsa004101.50331434
36Primary immunodeficiency_Homo sapiens_hsa053401.49532586
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49009956
38Starch and sucrose metabolism_Homo sapiens_hsa005001.47258074
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47140431
40ABC transporters_Homo sapiens_hsa020101.44040696
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42761640
42Retinol metabolism_Homo sapiens_hsa008301.42552498
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42082916
44Bile secretion_Homo sapiens_hsa049761.41222003
45Staphylococcus aureus infection_Homo sapiens_hsa051501.37119672
46Allograft rejection_Homo sapiens_hsa053301.36170666
47Tyrosine metabolism_Homo sapiens_hsa003501.36032665
48Ether lipid metabolism_Homo sapiens_hsa005651.34637129
49Fat digestion and absorption_Homo sapiens_hsa049751.29869312
50Pyruvate metabolism_Homo sapiens_hsa006201.29332342
51Graft-versus-host disease_Homo sapiens_hsa053321.27087400
52Fatty acid elongation_Homo sapiens_hsa000621.26909057
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26112092
54Type I diabetes mellitus_Homo sapiens_hsa049401.24741888
55Arachidonic acid metabolism_Homo sapiens_hsa005901.19856580
56Autoimmune thyroid disease_Homo sapiens_hsa053201.17962845
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15158903
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.14527034
59Protein export_Homo sapiens_hsa030601.06077444
60Steroid biosynthesis_Homo sapiens_hsa001001.01662065
61Lysine degradation_Homo sapiens_hsa003100.99617412
62Carbon metabolism_Homo sapiens_hsa012000.99122946
63Biosynthesis of amino acids_Homo sapiens_hsa012300.97559897
64Homologous recombination_Homo sapiens_hsa034400.91280707
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89399846
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87191100
67One carbon pool by folate_Homo sapiens_hsa006700.86734355
68Fanconi anemia pathway_Homo sapiens_hsa034600.86088834
69Arginine and proline metabolism_Homo sapiens_hsa003300.84941662
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84876995
71Vitamin digestion and absorption_Homo sapiens_hsa049770.83359441
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82358938
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80690481
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80400447
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78888401
76Basal transcription factors_Homo sapiens_hsa030220.78343323
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76976262
78Sulfur relay system_Homo sapiens_hsa041220.74297739
79Phototransduction_Homo sapiens_hsa047440.72782352
80Glycerolipid metabolism_Homo sapiens_hsa005610.71666166
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67451014
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67195035
83Hematopoietic cell lineage_Homo sapiens_hsa046400.65941812
84Antigen processing and presentation_Homo sapiens_hsa046120.64339887
85Vitamin B6 metabolism_Homo sapiens_hsa007500.64144647
86RNA degradation_Homo sapiens_hsa030180.63968180
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63705725
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.61242877
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60783492
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.55037142
91Insulin resistance_Homo sapiens_hsa049310.54221887
92Galactose metabolism_Homo sapiens_hsa000520.50562229
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49442777
94Glutathione metabolism_Homo sapiens_hsa004800.47381282
95Fructose and mannose metabolism_Homo sapiens_hsa000510.46952137
96Metabolic pathways_Homo sapiens_hsa011000.46605305
97Leishmaniasis_Homo sapiens_hsa051400.45973067
98Pentose phosphate pathway_Homo sapiens_hsa000300.45023930
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44648784
100Systemic lupus erythematosus_Homo sapiens_hsa053220.42832323
101Dorso-ventral axis formation_Homo sapiens_hsa043200.42092846
102Linoleic acid metabolism_Homo sapiens_hsa005910.39615517
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39317461
104T cell receptor signaling pathway_Homo sapiens_hsa046600.38340580
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.38116821
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36606590
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36458737
108Measles_Homo sapiens_hsa051620.36338413
109Glucagon signaling pathway_Homo sapiens_hsa049220.33547695
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.31834471
111Prion diseases_Homo sapiens_hsa050200.31117209
112Type II diabetes mellitus_Homo sapiens_hsa049300.28412937
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28111396
114Fatty acid biosynthesis_Homo sapiens_hsa000610.27825793
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27284984
116Mineral absorption_Homo sapiens_hsa049780.26776740
117Herpes simplex infection_Homo sapiens_hsa051680.25597821
118African trypanosomiasis_Homo sapiens_hsa051430.25512164
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.23279083
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.23081326
121Olfactory transduction_Homo sapiens_hsa047400.19854196
122Inositol phosphate metabolism_Homo sapiens_hsa005620.19483351
123Sphingolipid metabolism_Homo sapiens_hsa006000.19029708
124B cell receptor signaling pathway_Homo sapiens_hsa046620.18310090
125AMPK signaling pathway_Homo sapiens_hsa041520.17789161
126Insulin secretion_Homo sapiens_hsa049110.15997978
127Regulation of autophagy_Homo sapiens_hsa041400.13560537
128Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11250707
129Insulin signaling pathway_Homo sapiens_hsa049100.07865760
130Lysosome_Homo sapiens_hsa041420.07701983
131Thyroid hormone synthesis_Homo sapiens_hsa049180.04710771
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.04527600
133N-Glycan biosynthesis_Homo sapiens_hsa005100.01474239
134Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0959727
135Circadian rhythm_Homo sapiens_hsa04710-0.0935095
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0880978
137Other glycan degradation_Homo sapiens_hsa00511-0.0874370
138Prolactin signaling pathway_Homo sapiens_hsa04917-0.0812495
139Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0545864
140Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0387708
141Renin-angiotensin system_Homo sapiens_hsa04614-0.0161954

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