SEPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.37385216
2negative T cell selection (GO:0043383)5.90491606
3negative thymic T cell selection (GO:0045060)5.65210385
4regulation of gamma-delta T cell differentiation (GO:0045586)5.58906856
5positive thymic T cell selection (GO:0045059)5.40051702
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.14746645
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.14746645
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.14055282
9regulation of gamma-delta T cell activation (GO:0046643)5.03437277
10positive T cell selection (GO:0043368)4.99782139
11thymic T cell selection (GO:0045061)4.93496535
12response to interleukin-15 (GO:0070672)4.74428308
13T cell selection (GO:0045058)4.72028025
14antigen processing and presentation of endogenous antigen (GO:0019883)4.71273888
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.64832491
16negative regulation of cell killing (GO:0031342)4.64832491
17cellular response to interleukin-15 (GO:0071350)4.59147251
18interferon-gamma production (GO:0032609)4.37737070
19cytidine deamination (GO:0009972)4.37238772
20cytidine metabolic process (GO:0046087)4.37238772
21cytidine catabolic process (GO:0006216)4.37238772
22regulation of isotype switching to IgG isotypes (GO:0048302)4.36038678
23leukocyte aggregation (GO:0070486)4.33392816
24T cell receptor signaling pathway (GO:0050852)4.27752220
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.19209231
26pyrimidine ribonucleoside catabolic process (GO:0046133)4.13274552
27T cell migration (GO:0072678)4.13091357
28ribosomal small subunit assembly (GO:0000028)4.05643925
29T cell costimulation (GO:0031295)4.00796518
30lymphocyte costimulation (GO:0031294)3.96605633
31regulation of T cell mediated cytotoxicity (GO:0001914)3.94506393
32antigen receptor-mediated signaling pathway (GO:0050851)3.94023193
33regulation of B cell receptor signaling pathway (GO:0050855)3.91319072
34positive regulation of T cell mediated cytotoxicity (GO:0001916)3.90650526
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.86355423
36negative regulation of T cell mediated immunity (GO:0002710)3.73672274
37DNA deamination (GO:0045006)3.67629856
38immunoglobulin mediated immune response (GO:0016064)3.65174287
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.64775337
40viral transcription (GO:0019083)3.63401747
41regulation of leukocyte mediated cytotoxicity (GO:0001910)3.62967953
42positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.61475083
43regulation of T cell tolerance induction (GO:0002664)3.59631351
44negative regulation of leukocyte mediated immunity (GO:0002704)3.57486600
45B cell receptor signaling pathway (GO:0050853)3.51911237
46cellular response to type I interferon (GO:0071357)3.48846644
47type I interferon signaling pathway (GO:0060337)3.48846644
48regulation of T cell receptor signaling pathway (GO:0050856)3.48694802
49response to type I interferon (GO:0034340)3.47679578
50regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.46214636
51translational termination (GO:0006415)3.45888949
52V(D)J recombination (GO:0033151)3.44404698
53regulation of B cell differentiation (GO:0045577)3.43075446
54positive regulation of cell killing (GO:0031343)3.38464903
55regulation of cell killing (GO:0031341)3.38075571
56mucosal-associated lymphoid tissue development (GO:0048537)3.36965840
57Peyers patch development (GO:0048541)3.36965840
58regulation of alpha-beta T cell proliferation (GO:0046640)3.30989473
59detection of bacterium (GO:0016045)3.29418552
60regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.29206102
61positive regulation of interleukin-2 production (GO:0032743)3.21887996
62regulation of regulatory T cell differentiation (GO:0045589)3.20289330
63regulation of interleukin-2 biosynthetic process (GO:0045076)3.18303175
64ribosomal small subunit biogenesis (GO:0042274)3.17654100
65T cell homeostasis (GO:0043029)3.16222960
66positive regulation of isotype switching (GO:0045830)3.13875069
67tolerance induction (GO:0002507)3.13752934
68dendritic cell chemotaxis (GO:0002407)3.13686377
69negative regulation of T cell apoptotic process (GO:0070233)3.13500087
70positive regulation of tolerance induction (GO:0002645)3.13099001
71lymphocyte migration (GO:0072676)3.12080945
72detection of other organism (GO:0098543)3.11522225
73regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.11190055
74mast cell activation (GO:0045576)3.11042461
75positive regulation of defense response to virus by host (GO:0002230)3.09103677
76translational elongation (GO:0006414)3.08705583
77positive regulation of interleukin-4 production (GO:0032753)3.08476573
78positive regulation of alpha-beta T cell proliferation (GO:0046641)3.07472995
79regulation of alpha-beta T cell activation (GO:0046634)3.07053209
80positive regulation of calcium-mediated signaling (GO:0050850)3.05698220
81negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.05640005
82positive regulation of T cell mediated immunity (GO:0002711)3.04078372
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.03744374
84B cell mediated immunity (GO:0019724)3.02825839
85negative regulation of innate immune response (GO:0045824)3.02644035
86regulation of T cell mediated immunity (GO:0002709)3.01730576
87T cell differentiation (GO:0030217)3.01148984
88positive regulation of T cell differentiation in thymus (GO:0033089)2.99668601
89sequestering of actin monomers (GO:0042989)2.99200114
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98819079
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98229917
92antigen processing and presentation via MHC class Ib (GO:0002475)2.97244509
93positive regulation of B cell differentiation (GO:0045579)2.97068919
94maturation of SSU-rRNA (GO:0030490)2.96284725
95respiratory burst (GO:0045730)2.93993316
96regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.91531093
97regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.88886005
98DNA unwinding involved in DNA replication (GO:0006268)2.88632958
99regulation of response to interferon-gamma (GO:0060330)2.88254075
100regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.88158115
101regulation of natural killer cell mediated immunity (GO:0002715)2.88158115
102immune response-activating cell surface receptor signaling pathway (GO:0002429)2.87607518
103regulation of isotype switching (GO:0045191)2.86061194
104activated T cell proliferation (GO:0050798)2.84607911
105natural killer cell activation (GO:0030101)2.80746481
106cellular response to interleukin-4 (GO:0071353)2.79588363
107NIK/NF-kappaB signaling (GO:0038061)2.77950198
108SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.77795772
109Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76788400
110lymphocyte homeostasis (GO:0002260)2.76632649
111mast cell degranulation (GO:0043303)2.75060242
112mast cell activation involved in immune response (GO:0002279)2.75060242
113alpha-beta T cell activation (GO:0046631)2.74155860
114positive regulation of natural killer cell mediated immunity (GO:0002717)2.73326724
115positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.73326724
116regulation of type I interferon-mediated signaling pathway (GO:0060338)2.72892501
117translational initiation (GO:0006413)2.72706223
118T cell activation (GO:0042110)2.72148859
119negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.71574635
120regulation of tolerance induction (GO:0002643)2.70884703
121somatic cell DNA recombination (GO:0016444)2.70432258
122somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.70432258
123cotranslational protein targeting to membrane (GO:0006613)2.70098948
124viral life cycle (GO:0019058)2.69864892
125protein targeting to ER (GO:0045047)2.69740440
126cellular protein complex disassembly (GO:0043624)2.67861506
127positive regulation of granulocyte differentiation (GO:0030854)2.66600785
128negative regulation of T cell receptor signaling pathway (GO:0050860)2.66474084
129DNA strand elongation involved in DNA replication (GO:0006271)2.66279899
130positive regulation of DNA recombination (GO:0045911)2.64258253
131regulation of interleukin-12 biosynthetic process (GO:0045075)2.63195196
132telomere maintenance via semi-conservative replication (GO:0032201)2.62069462
133leukocyte cell-cell adhesion (GO:0007159)2.61624933
134somatic diversification of immune receptors (GO:0002200)2.61551696
135negative regulation of phagocytosis (GO:0050765)2.60161041
136alpha-beta T cell differentiation (GO:0046632)2.59150911
137DNA strand elongation (GO:0022616)2.56117917
138positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56095979
139regulation of B cell mediated immunity (GO:0002712)2.56049866
140positive regulation of immunoglobulin production (GO:0002639)2.56004874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.80575373
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.18181303
3MYC_22102868_ChIP-Seq_BL_Human3.63472671
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58691499
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82440239
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.82336922
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77231912
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.75386252
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53023153
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.51206978
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.42817009
12MYB_26560356_Chip-Seq_TH2_Human2.42227414
13VDR_21846776_ChIP-Seq_THP-1_Human2.39890362
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36870124
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32618021
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.31081874
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.28725313
18MAF_26560356_Chip-Seq_TH1_Human2.27017309
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23063500
20RUNX_20019798_ChIP-Seq_JUKART_Human2.19408741
21UTX_26944678_Chip-Seq_JUKART_Human2.18290864
22MYB_26560356_Chip-Seq_TH1_Human2.15263209
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.09939492
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06810820
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96437051
26CIITA_25753668_ChIP-Seq_RAJI_Human1.95741490
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92615486
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90321068
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89402457
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89140263
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85375333
32GATA3_26560356_Chip-Seq_TH2_Human1.85245045
33SCL_19346495_ChIP-Seq_HPC-7_Human1.81351514
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.80357331
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76351869
36SPI1_23547873_ChIP-Seq_NB4_Human1.73446395
37VDR_23849224_ChIP-Seq_CD4+_Human1.73396817
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73243093
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69788281
40MAF_26560356_Chip-Seq_TH2_Human1.68268361
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.67279805
42TCF7_22412390_ChIP-Seq_EML_Mouse1.67222198
43FOXP3_21729870_ChIP-Seq_TREG_Human1.66972358
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.63771268
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60693197
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.59786103
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59054780
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.56911899
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55364897
50XRN2_22483619_ChIP-Seq_HELA_Human1.53639803
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53172714
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52939123
53BCL6_27268052_Chip-Seq_Bcells_Human1.45600995
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44000272
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42333559
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.41291356
57VDR_24763502_ChIP-Seq_THP-1_Human1.41133045
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39955879
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.36934709
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33367835
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31980051
62GATA3_27048872_Chip-Seq_THYMUS_Human1.31868812
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.31557963
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31033052
65KDM2B_26808549_Chip-Seq_DND41_Human1.28099753
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27905671
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27419167
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26260028
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26198826
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25550248
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24989954
72BCOR_27268052_Chip-Seq_Bcells_Human1.23274365
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22989196
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22898199
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.21458672
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20381686
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.20194238
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19719538
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17113593
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15791476
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15571501
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15268758
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15114761
84KDM5A_27292631_Chip-Seq_BREAST_Human1.13519578
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12492923
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10280852
87GATA1_19941827_ChIP-Seq_MEL_Mouse1.09956556
88P300_27268052_Chip-Seq_Bcells_Human1.09082337
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08678863
90ELK1_19687146_ChIP-ChIP_HELA_Human1.08301842
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07572180
92GABP_19822575_ChIP-Seq_HepG2_Human1.07530027
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05085342
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.02941789
95IRF8_27001747_Chip-Seq_BMDM_Mouse1.02931934
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02584021
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01987939
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01945872
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01602752
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00530546
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00287107
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00115905
103EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99224339
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99077200
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98857710
106PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98548190
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98158862
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98118043
109RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97811210
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97024890
111SPI1_23127762_ChIP-Seq_K562_Human0.96867628
112DCP1A_22483619_ChIP-Seq_HELA_Human0.96677214
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.94679382
114CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94430500
115TTF2_22483619_ChIP-Seq_HELA_Human0.94372035
116LXR_22292898_ChIP-Seq_THP-1_Human0.94105139
117KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92764066
118TP63_19390658_ChIP-ChIP_HaCaT_Human0.92740088
119E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92620224
120SPI1_20517297_ChIP-Seq_HL60_Human0.91127156
121P68_20966046_ChIP-Seq_HELA_Human0.91015251
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90995048
123RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90604498
124MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90540112
125VDR_24787735_ChIP-Seq_THP-1_Human0.90447681
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89466560
127CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89430419
128MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88203226
129TFEB_21752829_ChIP-Seq_HELA_Human0.87670395
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87598902
131CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87523177
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.87464267
133GATA1_19941826_ChIP-Seq_K562_Human0.86554994
134BP1_19119308_ChIP-ChIP_Hs578T_Human0.86511795
135CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85531951
136CTCF_26484167_Chip-Seq_Bcells_Mouse0.85468806
137CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84881440
138GATA3_26560356_Chip-Seq_TH1_Human0.83775194
139RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83772963
140E2F1_20622854_ChIP-Seq_HELA_Human0.83300039
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.83124831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.92758542
2MP0005671_abnormal_response_to3.94618319
3MP0000685_abnormal_immune_system3.45963689
4MP0001835_abnormal_antigen_presentation3.31209222
5MP0001800_abnormal_humoral_immune3.19707270
6MP0002398_abnormal_bone_marrow2.97240833
7MP0002396_abnormal_hematopoietic_system2.91982811
8MP0005387_immune_system_phenotype2.76389301
9MP0001790_abnormal_immune_system2.76389301
10MP0000703_abnormal_thymus_morphology2.71539230
11MP0002420_abnormal_adaptive_immunity2.67749585
12MP0001819_abnormal_immune_cell2.62859625
13MP0009333_abnormal_splenocyte_physiolog2.61071181
14MP0002723_abnormal_immune_serum2.55654619
15MP0002166_altered_tumor_susceptibility2.50403902
16MP0002452_abnormal_antigen_presenting2.49463571
17MP0005000_abnormal_immune_tolerance2.49139085
18MP0002722_abnormal_immune_system2.48540369
19MP0000716_abnormal_immune_system2.47195200
20MP0008057_abnormal_DNA_replication2.46306968
21MP0000689_abnormal_spleen_morphology2.43245393
22MP0010094_abnormal_chromosome_stability2.33454835
23MP0002405_respiratory_system_inflammati2.28848125
24MP0009785_altered_susceptibility_to2.26732602
25MP0003693_abnormal_embryo_hatching2.16384916
26MP0005025_abnormal_response_to2.13912671
27MP0002429_abnormal_blood_cell2.13186824
28MP0001873_stomach_inflammation2.12035812
29MP0002006_tumorigenesis2.06091069
30MP0003077_abnormal_cell_cycle2.04839435
31MP0010155_abnormal_intestine_physiology2.02718651
32MP0004957_abnormal_blastocyst_morpholog1.99620499
33MP0004808_abnormal_hematopoietic_stem1.96076177
34MP0003111_abnormal_nucleus_morphology1.88639873
35MP0006082_CNS_inflammation1.88025602
36MP0003436_decreased_susceptibility_to1.86292796
37MP0003866_abnormal_defecation1.83052256
38MP0004947_skin_inflammation1.71090139
39MP0000490_abnormal_crypts_of1.70195098
40MP0010352_gastrointestinal_tract_polyps1.65760868
41MP0005464_abnormal_platelet_physiology1.55431841
42MP0008058_abnormal_DNA_repair1.54567872
43MP0003300_gastrointestinal_ulcer1.53407868
44MP0002019_abnormal_tumor_incidence1.52482227
45MP0002933_joint_inflammation1.49263519
46MP0005397_hematopoietic_system_phenotyp1.48802325
47MP0001545_abnormal_hematopoietic_system1.48802325
48MP0002148_abnormal_hypersensitivity_rea1.47279335
49MP0001853_heart_inflammation1.44718109
50MP0002419_abnormal_innate_immunity1.44183308
51MP0001845_abnormal_inflammatory_respons1.43633708
52MP0000858_altered_metastatic_potential1.43590625
53MP0005075_abnormal_melanosome_morpholog1.40018446
54MP0009278_abnormal_bone_marrow1.37753093
55MP0002132_abnormal_respiratory_system1.36708034
56MP0003303_peritoneal_inflammation1.31155626
57MP0008007_abnormal_cellular_replicative1.29820596
58MP0003724_increased_susceptibility_to1.21758325
59MP0000465_gastrointestinal_hemorrhage1.21733741
60MP0002138_abnormal_hepatobiliary_system1.18340007
61MP0005310_abnormal_salivary_gland1.16558039
62MP0000350_abnormal_cell_proliferation1.14672379
63MP0001730_embryonic_growth_arrest1.04213543
64MP0009764_decreased_sensitivity_to1.03840317
65MP0003448_altered_tumor_morphology1.02230987
66MP0001986_abnormal_taste_sensitivity1.01335992
67MP0000313_abnormal_cell_death0.97801743
68MP0003045_fibrosis0.96768629
69MP0005174_abnormal_tail_pigmentation0.96566975
70MP0004510_myositis0.94138344
71MP0005076_abnormal_cell_differentiation0.90563643
72MP0010307_abnormal_tumor_latency0.89111266
73MP0005023_abnormal_wound_healing0.88122960
74MP0002277_abnormal_respiratory_mucosa0.86974668
75MP0004381_abnormal_hair_follicle0.86622439
76MP0002009_preneoplasia0.86205042
77MP0003172_abnormal_lysosome_physiology0.84492323
78MP0002998_abnormal_bone_remodeling0.83306384
79MP0008469_abnormal_protein_level0.81836200
80MP0003786_premature_aging0.81761728
81MP0002693_abnormal_pancreas_physiology0.78945094
82MP0000477_abnormal_intestine_morphology0.77574071
83MP0002086_abnormal_extraembryonic_tissu0.77121836
84MP0003191_abnormal_cellular_cholesterol0.76237045
85MP0001663_abnormal_digestive_system0.75340505
86MP0002095_abnormal_skin_pigmentation0.74544244
87MP0002080_prenatal_lethality0.72415734
88MP0003183_abnormal_peptide_metabolism0.70664459
89MP0008877_abnormal_DNA_methylation0.69534866
90MP0001697_abnormal_embryo_size0.67313643
91MP0001672_abnormal_embryogenesis/_devel0.66331498
92MP0005380_embryogenesis_phenotype0.66331498
93MP0005166_decreased_susceptibility_to0.65304641
94MP0003984_embryonic_growth_retardation0.64278422
95MP0005645_abnormal_hypothalamus_physiol0.63504207
96MP0002088_abnormal_embryonic_growth/wei0.62711067
97MP0001851_eye_inflammation0.60036158
98MP0002163_abnormal_gland_morphology0.59898229
99MP0004130_abnormal_muscle_cell0.58492847
100MP0008961_abnormal_basal_metabolism0.58140610
101MP0004883_abnormal_blood_vessel0.57088120
102MP0001348_abnormal_lacrimal_gland0.56613170
103MP0003252_abnormal_bile_duct0.56310712
104MP0001533_abnormal_skeleton_physiology0.56142544
105MP0009763_increased_sensitivity_to0.55492575
106MP0009765_abnormal_xenobiotic_induced0.54026222
107MP0005390_skeleton_phenotype0.53902645
108MP0003828_pulmonary_edema0.52275707
109MP0008932_abnormal_embryonic_tissue0.51978324
110MP0001919_abnormal_reproductive_system0.51417571
111MP0000015_abnormal_ear_pigmentation0.50506645
112MP0000249_abnormal_blood_vessel0.50363837
113MP0008260_abnormal_autophagy0.50308244
114MP0001765_abnormal_ion_homeostasis0.50037122
115MP0002136_abnormal_kidney_physiology0.49747425
116MP0003795_abnormal_bone_structure0.49661651
117MP0005621_abnormal_cell_physiology0.49640005
118MP0003787_abnormal_imprinting0.49157523
119MP0004197_abnormal_fetal_growth/weight/0.48728869
120MP0000371_diluted_coat_color0.48353199
121MP0008770_decreased_survivor_rate0.47795478
122MP0002085_abnormal_embryonic_tissue0.46589178
123MP0002084_abnormal_developmental_patter0.45164472
124MP0008873_increased_physiological_sensi0.44897770
125MP0002083_premature_death0.43718300
126MP0002928_abnormal_bile_duct0.42840948
127MP0009642_abnormal_blood_homeostasis0.41595140
128MP0008874_decreased_physiological_sensi0.39686493
129MP0009643_abnormal_urine_homeostasis0.38717176
130MP0000609_abnormal_liver_physiology0.37580805
131MP0005381_digestive/alimentary_phenotyp0.35312810

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.51639614
2Abnormality of T cell number (HP:0011839)6.20585504
3Severe combined immunodeficiency (HP:0004430)5.12975822
4Combined immunodeficiency (HP:0005387)5.07035367
5Abnormality of T cells (HP:0002843)4.95009231
6Panhypogammaglobulinemia (HP:0003139)4.88380357
7IgM deficiency (HP:0002850)4.87516565
8Recurrent bronchitis (HP:0002837)4.86895617
9Recurrent viral infections (HP:0004429)4.45385691
10B lymphocytopenia (HP:0010976)4.29897165
11Abnormality of B cell number (HP:0010975)4.29897165
12IgG deficiency (HP:0004315)4.23127796
13Recurrent bacterial skin infections (HP:0005406)4.17876652
14Recurrent fungal infections (HP:0002841)4.02596975
15Thyroiditis (HP:0100646)3.98542897
16Elevated erythrocyte sedimentation rate (HP:0003565)3.96746029
17Abnormality of macrophages (HP:0004311)3.88376095
18Chronic otitis media (HP:0000389)3.84910035
19Agammaglobulinemia (HP:0004432)3.79243712
20Orchitis (HP:0100796)3.76320786
21Nasal polyposis (HP:0100582)3.75268845
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.73491781
23Abnormality of the fingertips (HP:0001211)3.53704862
24Lymphopenia (HP:0001888)3.48191470
25Abnormality of T cell physiology (HP:0011840)3.46408894
26Basal cell carcinoma (HP:0002671)3.43705820
27Abnormality of cells of the lymphoid lineage (HP:0012140)3.42341373
28Gastrointestinal infarctions (HP:0005244)3.41067153
29Pustule (HP:0200039)3.37131745
30Abnormality of eosinophils (HP:0001879)3.35238988
31Eosinophilia (HP:0001880)3.23244008
32Meningitis (HP:0001287)3.21707111
33Chronic mucocutaneous candidiasis (HP:0002728)3.19871241
34Recurrent cutaneous fungal infections (HP:0011370)3.19871241
35Lymphoma (HP:0002665)3.15693165
36Abnormality of the nasal mucosa (HP:0000433)3.14334090
37Stomatitis (HP:0010280)3.14171377
38Myositis (HP:0100614)3.04904830
39Hypoplasia of the thymus (HP:0000778)3.04347509
40Granulocytopenia (HP:0001913)3.00432040
41Papilloma (HP:0012740)2.96609227
42Verrucae (HP:0200043)2.96609227
43Recurrent gram-negative bacterial infections (HP:0005420)2.93631629
44Recurrent sinusitis (HP:0011108)2.93156937
45IgA deficiency (HP:0002720)2.90008977
46Autoimmune hemolytic anemia (HP:0001890)2.86269737
47Leukocytosis (HP:0001974)2.83267703
48Gastrointestinal inflammation (HP:0004386)2.81822887
49Keratoconjunctivitis sicca (HP:0001097)2.79021820
50Inflammation of the large intestine (HP:0002037)2.78401760
51Bronchitis (HP:0012387)2.75409063
52Eczematoid dermatitis (HP:0000976)2.74045218
53Increased IgM level (HP:0003496)2.71652031
54Chronic diarrhea (HP:0002028)2.71504981
55Thrombocytosis (HP:0001894)2.70402698
56Keratoconjunctivitis (HP:0001096)2.68601774
57Reticulocytopenia (HP:0001896)2.64886501
58Urticaria (HP:0001025)2.52245289
59Cellulitis (HP:0100658)2.49590240
60Abnormality of cells of the erythroid lineage (HP:0012130)2.49557864
61Encephalitis (HP:0002383)2.49492097
62Autoimmune thrombocytopenia (HP:0001973)2.48899289
63Vasculitis (HP:0002633)2.46466732
64Abnormality of the prostate (HP:0008775)2.44698371
65Recurrent abscess formation (HP:0002722)2.37741876
66Abnormal number of erythroid precursors (HP:0012131)2.36952952
67Gastrointestinal stroma tumor (HP:0100723)2.36398630
68Chronic sinusitis (HP:0011109)2.33755089
69Poikiloderma (HP:0001029)2.32696474
70Amaurosis fugax (HP:0100576)2.31491808
71Spontaneous hematomas (HP:0007420)2.28080660
72Recurrent otitis media (HP:0000403)2.28051969
73Colitis (HP:0002583)2.25516849
74Abnormality of the pleura (HP:0002103)2.25467116
75Pulmonary embolism (HP:0002204)2.24811207
76Increased IgE level (HP:0003212)2.22348779
77Acute hepatic failure (HP:0006554)2.22068856
78Joint swelling (HP:0001386)2.21590866
79Papilledema (HP:0001085)2.17423908
80Mediastinal lymphadenopathy (HP:0100721)2.17366411
81Aplasia/Hypoplasia of the thymus (HP:0010515)2.15929976
82Gingivitis (HP:0000230)2.14521266
83Stomach cancer (HP:0012126)2.09698198
84Skin rash (HP:0000988)2.08938486
85Prolonged bleeding time (HP:0003010)2.08343891
86Arterial thrombosis (HP:0004420)2.06089028
87Obstructive lung disease (HP:0006536)2.04471313
88Chronic obstructive pulmonary disease (HP:0006510)2.04471313
89Gangrene (HP:0100758)2.04358753
90Hypergammaglobulinemia (HP:0010702)2.03619655
91Anorexia (HP:0002039)2.02210359
92Emphysema (HP:0002097)2.01267213
93Osteomyelitis (HP:0002754)1.98258560
94Recurrent skin infections (HP:0001581)1.97739955
95Myelodysplasia (HP:0002863)1.96594585
96Hypochromic anemia (HP:0001931)1.94850637
97Ependymoma (HP:0002888)1.92689529
98Hypoproteinemia (HP:0003075)1.91262422
99Hypochromic microcytic anemia (HP:0004840)1.91120668
100Gingival bleeding (HP:0000225)1.88854108
101Recurrent pneumonia (HP:0006532)1.88748514
102Prominent nose (HP:0000448)1.88456307
103Petechiae (HP:0000967)1.86500732
104Birth length less than 3rd percentile (HP:0003561)1.86245841
105Hemoptysis (HP:0002105)1.83844264
106Cellular immunodeficiency (HP:0005374)1.83802010
107Abnormal platelet volume (HP:0011876)1.82987139
108Leukopenia (HP:0001882)1.82722248
109Skin ulcer (HP:0200042)1.81030625
110Retrobulbar optic neuritis (HP:0100654)1.80563945
111Optic neuritis (HP:0100653)1.80563945
112Epistaxis (HP:0000421)1.78740560
113Pulmonary infiltrates (HP:0002113)1.77556759
114Volvulus (HP:0002580)1.76792125
115Chest pain (HP:0100749)1.76616816
116Pallor (HP:0000980)1.74688653
117Aplastic anemia (HP:0001915)1.74134236
118Medulloblastoma (HP:0002885)1.72704080
119Sepsis (HP:0100806)1.72595284
120Abnormality of DNA repair (HP:0003254)1.71864268
121Absent thumb (HP:0009777)1.71617411
122Squamous cell carcinoma (HP:0002860)1.70245911
123Microcytic anemia (HP:0001935)1.70071632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.84212201
2TXK4.42862207
3TAOK33.04904028
4RIPK42.90839019
5GRK62.86209122
6ZAP702.83699457
7EEF2K2.81165454
8STK102.71763089
9MAP3K102.48348866
10ITK2.45879043
11JAK32.37113241
12CDK122.06211878
13TESK21.96178244
14TYK21.87235676
15PRPF4B1.83417449
16FGFR41.82979434
17BTK1.77007158
18SYK1.74559979
19LCK1.70681860
20IKBKE1.61525820
21KDR1.57567355
22NME21.57061409
23CDC71.51038317
24CSK1.48396882
25TEC1.47937138
26RPS6KB21.46600703
27NLK1.46052240
28MST41.44185608
29BLK1.43164659
30LRRK21.40890125
31PIM11.34880199
32CSF1R1.34483295
33NEK21.32471556
34JAK11.28670900
35FGFR31.28513474
36PKN21.23239221
37HCK1.22332879
38CLK11.19755264
39FLT31.18976711
40MAP3K111.18573641
41MAP3K141.14618301
42KIT1.14265607
43CDK41.13453047
44BUB11.04125344
45PASK1.03962458
46TBK11.03180255
47TNK21.02240065
48RPS6KA41.00751957
49SIK21.00089160
50STK41.00007981
51LYN0.94991713
52IKBKB0.93546489
53BRD40.93287707
54CAMKK20.91822788
55MAP2K20.91082368
56MARK30.89801260
57TLK10.85288766
58PRKCQ0.84652159
59ALK0.81579484
60ATR0.81453040
61CAMKK10.79169379
62WEE10.76413786
63BMPR20.75001998
64TGFBR10.72522618
65BCKDK0.72252241
66MAP3K130.71446388
67PRKCH0.70942027
68MAPKAPK30.70741916
69GRK70.69748619
70MAP3K80.69547781
71IRAK40.66593749
72CDK70.66015335
73MAP3K70.65582211
74TSSK60.63299205
75FYN0.62300210
76FGR0.62038355
77ACVR1B0.61954283
78MAP2K30.60983724
79FES0.60756712
80MAPK120.58981952
81EIF2AK10.57662688
82MELK0.57498534
83MAPK110.57038047
84CHEK10.56255358
85ERN10.55335383
86CHUK0.54985193
87SIK30.54712957
88HIPK20.54388963
89MAP2K60.52573554
90SRPK10.51553348
91SMG10.51041697
92JAK20.50600415
93PIK3CG0.49116908
94TRIB30.48845912
95ADRBK20.48750602
96CDK60.46409198
97TAOK10.46039193
98TGFBR20.45860609
99EIF2AK30.45756912
100DYRK30.45051427
101CDK90.43236354
102MAP3K10.42845124
103TYRO30.42839318
104CDK20.38769014
105CDC42BPA0.38729856
106PLK10.37500943
107MAPK70.37319642
108PRKD20.37075649
109MAPKAPK20.36595138
110TESK10.36231903
111MARK20.36126072
112* AURKB0.35662947
113ATM0.35270214
114VRK10.35100580
115PDGFRB0.34884293
116NUAK10.34662789
117INSR0.34498186
118EPHA30.33373079
119MAP3K30.32341506
120RPS6KA50.31739185
121MAPK30.29891168
122IRAK10.29109941
123RPS6KA60.28288062
124MAPK40.27546793
125EPHB10.27506202
126PDK10.27471425
127RPS6KC10.25263485
128RPS6KL10.25263485
129MATK0.24839796
130STK110.24407909
131GRK50.23276139
132TAOK20.22660526
133ABL10.22316282
134PTK60.22275946
135IGF1R0.19366983
136PRKD10.18876629
137PDPK10.17643971
138PRKCD0.17140308

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.55072870
2DNA replication_Homo sapiens_hsa030302.98064579
3T cell receptor signaling pathway_Homo sapiens_hsa046602.90464446
4Mismatch repair_Homo sapiens_hsa034302.69750372
5Ribosome_Homo sapiens_hsa030102.65385510
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.46776571
7Antigen processing and presentation_Homo sapiens_hsa046122.40223030
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.34330479
9Measles_Homo sapiens_hsa051622.19491964
10Base excision repair_Homo sapiens_hsa034102.18905515
11Spliceosome_Homo sapiens_hsa030402.15405021
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.09508944
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07592087
14Hematopoietic cell lineage_Homo sapiens_hsa046402.05729163
15Non-homologous end-joining_Homo sapiens_hsa034502.05273147
16B cell receptor signaling pathway_Homo sapiens_hsa046622.04199094
17Staphylococcus aureus infection_Homo sapiens_hsa051501.80624714
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76644818
19Graft-versus-host disease_Homo sapiens_hsa053321.74436663
20Allograft rejection_Homo sapiens_hsa053301.71404929
21Nucleotide excision repair_Homo sapiens_hsa034201.62078888
22Herpes simplex infection_Homo sapiens_hsa051681.60083674
23Homologous recombination_Homo sapiens_hsa034401.54187295
24RNA transport_Homo sapiens_hsa030131.47225173
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44515324
26Viral myocarditis_Homo sapiens_hsa054161.38260239
27Leishmaniasis_Homo sapiens_hsa051401.37452676
28Cell cycle_Homo sapiens_hsa041101.33773347
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.33575551
30Osteoclast differentiation_Homo sapiens_hsa043801.28879232
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28772277
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28735766
33Acute myeloid leukemia_Homo sapiens_hsa052211.25496143
34Rheumatoid arthritis_Homo sapiens_hsa053231.22207331
35RNA degradation_Homo sapiens_hsa030181.21766766
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21086863
37One carbon pool by folate_Homo sapiens_hsa006701.18968928
38Autoimmune thyroid disease_Homo sapiens_hsa053201.18309676
39Fanconi anemia pathway_Homo sapiens_hsa034601.17746822
40mRNA surveillance pathway_Homo sapiens_hsa030151.17476102
41HTLV-I infection_Homo sapiens_hsa051661.16763794
42Epstein-Barr virus infection_Homo sapiens_hsa051691.15444988
43p53 signaling pathway_Homo sapiens_hsa041151.15284970
44RNA polymerase_Homo sapiens_hsa030201.13999795
45Viral carcinogenesis_Homo sapiens_hsa052031.10454084
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.07648843
47Hepatitis B_Homo sapiens_hsa051611.07508672
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06062750
49Shigellosis_Homo sapiens_hsa051311.03660294
50Pyrimidine metabolism_Homo sapiens_hsa002401.00876264
51Proteasome_Homo sapiens_hsa030500.97111936
52Apoptosis_Homo sapiens_hsa042100.95415570
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90965988
54Colorectal cancer_Homo sapiens_hsa052100.90420086
55Chemokine signaling pathway_Homo sapiens_hsa040620.89587373
56Chronic myeloid leukemia_Homo sapiens_hsa052200.88595637
57Influenza A_Homo sapiens_hsa051640.84355444
58Toxoplasmosis_Homo sapiens_hsa051450.82718728
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79793508
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78427946
61Basal transcription factors_Homo sapiens_hsa030220.75608092
62Pancreatic cancer_Homo sapiens_hsa052120.75499419
63Notch signaling pathway_Homo sapiens_hsa043300.75043105
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69620169
65African trypanosomiasis_Homo sapiens_hsa051430.68532091
66Platelet activation_Homo sapiens_hsa046110.68276878
67Non-small cell lung cancer_Homo sapiens_hsa052230.67664320
68Legionellosis_Homo sapiens_hsa051340.67074451
69VEGF signaling pathway_Homo sapiens_hsa043700.61064700
70Systemic lupus erythematosus_Homo sapiens_hsa053220.61047515
71Asthma_Homo sapiens_hsa053100.60582093
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60014160
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59943785
74Pertussis_Homo sapiens_hsa051330.59499851
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58348410
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57948041
77Thyroid cancer_Homo sapiens_hsa052160.57683594
78Small cell lung cancer_Homo sapiens_hsa052220.55574367
79TNF signaling pathway_Homo sapiens_hsa046680.52726835
80* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50532315
81Hepatitis C_Homo sapiens_hsa051600.45992039
82Endocytosis_Homo sapiens_hsa041440.45988438
83Malaria_Homo sapiens_hsa051440.44638582
84Pentose phosphate pathway_Homo sapiens_hsa000300.44425046
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43941373
86Phagosome_Homo sapiens_hsa041450.43933931
87Type I diabetes mellitus_Homo sapiens_hsa049400.43526745
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43296421
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42308447
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.42114617
91MicroRNAs in cancer_Homo sapiens_hsa052060.41843782
92mTOR signaling pathway_Homo sapiens_hsa041500.41578097
93Tuberculosis_Homo sapiens_hsa051520.40214680
94Prolactin signaling pathway_Homo sapiens_hsa049170.39634647
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36683928
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36306194
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.35478791
98FoxO signaling pathway_Homo sapiens_hsa040680.34375184
99Linoleic acid metabolism_Homo sapiens_hsa005910.34226162
100Other glycan degradation_Homo sapiens_hsa005110.33755753
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32673782
102Sulfur relay system_Homo sapiens_hsa041220.31540458
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.31099110
104MAPK signaling pathway_Homo sapiens_hsa040100.30089497
105Regulation of autophagy_Homo sapiens_hsa041400.29919097
106Pathways in cancer_Homo sapiens_hsa052000.29844498
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29629236
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29600234
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29580329
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.28741620
111Salmonella infection_Homo sapiens_hsa051320.28163237
112Purine metabolism_Homo sapiens_hsa002300.27435854
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.26957413
114Endometrial cancer_Homo sapiens_hsa052130.25920700
115Prostate cancer_Homo sapiens_hsa052150.25531855
116HIF-1 signaling pathway_Homo sapiens_hsa040660.25319108
117Inositol phosphate metabolism_Homo sapiens_hsa005620.25264400
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24331031
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24293405
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22197421
121Insulin resistance_Homo sapiens_hsa049310.19342349
122Ras signaling pathway_Homo sapiens_hsa040140.18175195
123Choline metabolism in cancer_Homo sapiens_hsa052310.18104559
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17241588
125Arachidonic acid metabolism_Homo sapiens_hsa005900.16047725
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.14874558
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.13797633
128ABC transporters_Homo sapiens_hsa020100.11577821
129Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.08402340
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08360447
131Phototransduction_Homo sapiens_hsa047440.06476424
132Ether lipid metabolism_Homo sapiens_hsa005650.06308128
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04847322
134Renal cell carcinoma_Homo sapiens_hsa052110.04277622

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