SEPT10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. A pseudogene for this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)3.94472723
2fusion of sperm to egg plasma membrane (GO:0007342)3.91606300
3sperm-egg recognition (GO:0035036)3.74142805
4hemidesmosome assembly (GO:0031581)3.73612952
5nuclear pore complex assembly (GO:0051292)3.64732621
6binding of sperm to zona pellucida (GO:0007339)3.64379109
7acrosome assembly (GO:0001675)3.61482845
8nuclear pore organization (GO:0006999)3.59017432
9paraxial mesoderm development (GO:0048339)3.36270723
10multicellular organism reproduction (GO:0032504)3.31343271
11cell wall macromolecule metabolic process (GO:0044036)3.27988479
12cell wall macromolecule catabolic process (GO:0016998)3.27988479
13cell-cell recognition (GO:0009988)3.18689521
14skin morphogenesis (GO:0043589)3.17143889
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.12870038
16anterior/posterior axis specification, embryo (GO:0008595)3.12462570
17desmosome organization (GO:0002934)3.06943859
18endodermal cell differentiation (GO:0035987)3.06314054
19G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.02833249
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01908651
21regulation of transforming growth factor beta2 production (GO:0032909)3.01325518
22planar cell polarity pathway involved in neural tube closure (GO:0090179)3.00383184
23glomerulus development (GO:0032835)2.99134072
24embryonic foregut morphogenesis (GO:0048617)2.95052723
25axonemal dynein complex assembly (GO:0070286)2.94082986
26regulation of cardioblast differentiation (GO:0051890)2.93090069
27ventricular cardiac muscle cell development (GO:0055015)2.92534981
28cell migration involved in sprouting angiogenesis (GO:0002042)2.92423265
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90799224
30glomerular visceral epithelial cell development (GO:0072015)2.85892232
31pore complex assembly (GO:0046931)2.84582260
32sperm motility (GO:0030317)2.84351962
33mesodermal cell differentiation (GO:0048333)2.81711555
34COPII vesicle coating (GO:0048208)2.80574749
35negative regulation of chondrocyte differentiation (GO:0032331)2.75274311
36negative regulation of DNA repair (GO:0045738)2.75173619
37piRNA metabolic process (GO:0034587)2.74786281
38endothelial cell morphogenesis (GO:0001886)2.73077483
39reproduction (GO:0000003)2.70941173
40bundle of His cell to Purkinje myocyte communication (GO:0086069)2.68136880
41cell-substrate junction assembly (GO:0007044)2.67708241
42establishment of apical/basal cell polarity (GO:0035089)2.67337563
43polarized epithelial cell differentiation (GO:0030859)2.67051527
44lymph vessel development (GO:0001945)2.65586545
45lung vasculature development (GO:0060426)2.65481116
46substrate adhesion-dependent cell spreading (GO:0034446)2.62429500
47epithelial cilium movement (GO:0003351)2.60373321
48neural crest cell development (GO:0014032)2.59430023
49regulation of centriole replication (GO:0046599)2.58510081
50establishment of integrated proviral latency (GO:0075713)2.58478781
51epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58389994
52plasma membrane fusion (GO:0045026)2.58212249
53mitotic chromosome condensation (GO:0007076)2.57753462
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57270206
55cellular glucuronidation (GO:0052695)2.56844761
56uronic acid metabolic process (GO:0006063)2.55110897
57glucuronate metabolic process (GO:0019585)2.55110897
58male meiosis (GO:0007140)2.54747326
59epithelial cell-cell adhesion (GO:0090136)2.54533097
60glomerular epithelial cell development (GO:0072310)2.47695887
61glomerular basement membrane development (GO:0032836)2.46975407
62outer ear morphogenesis (GO:0042473)2.46841831
63Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.46683542
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.46581232
65positive regulation of SMAD protein import into nucleus (GO:0060391)2.44919457
66mitotic cytokinesis (GO:0000281)2.44643605
67regulation of establishment of planar polarity (GO:0090175)2.43184594
68collagen fibril organization (GO:0030199)2.42661443
69neuron projection extension involved in neuron projection guidance (GO:1902284)2.42381132
70axon extension involved in axon guidance (GO:0048846)2.42381132
71phagocytosis, recognition (GO:0006910)2.42118281
72spermatid development (GO:0007286)2.41236493
73chondrocyte proliferation (GO:0035988)2.40706052
74mesenchymal-epithelial cell signaling (GO:0060638)2.40211668
75regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.40144100
76hippo signaling (GO:0035329)2.38945664
77negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.37930837
78notochord development (GO:0030903)2.36572260
79regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.36392278
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.35352012
81regulation of protein polyubiquitination (GO:1902914)2.35048572
82protein heterotrimerization (GO:0070208)2.34994990
83convergent extension (GO:0060026)2.34878283
84mesenchymal cell development (GO:0014031)2.34624656
85establishment of tissue polarity (GO:0007164)2.33669673
86establishment of planar polarity (GO:0001736)2.33669673
87regulation of integrin-mediated signaling pathway (GO:2001044)2.33309805
88regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.33069325
89low-density lipoprotein particle clearance (GO:0034383)2.32693680
90gap junction assembly (GO:0016264)2.32629493
91basement membrane organization (GO:0071711)2.32431034
92wound healing, spreading of epidermal cells (GO:0035313)2.31945137
93metanephric mesenchyme development (GO:0072075)2.31695347
94regulation of cell fate specification (GO:0042659)2.30439931
95apoptotic cell clearance (GO:0043277)2.30351433
96genitalia morphogenesis (GO:0035112)2.29782482
97synaptonemal complex assembly (GO:0007130)2.29596757
98endocardial cushion development (GO:0003197)2.29309998
99sequestering of extracellular ligand from receptor (GO:0035581)2.29126113
100negative regulation of cartilage development (GO:0061037)2.29062295
101synaptonemal complex organization (GO:0070193)2.28184817
102Golgi transport vesicle coating (GO:0048200)2.28133929
103COPI coating of Golgi vesicle (GO:0048205)2.28133929
104branching involved in salivary gland morphogenesis (GO:0060445)2.27590384
105protein retention in ER lumen (GO:0006621)2.27445353
106mitotic metaphase plate congression (GO:0007080)2.27029124
107protein localization to chromosome, centromeric region (GO:0071459)2.26566335
108non-canonical Wnt signaling pathway (GO:0035567)2.26380187
109metaphase plate congression (GO:0051310)2.25907639
110substrate-dependent cell migration (GO:0006929)2.25873943
111adherens junction assembly (GO:0034333)2.24874179
112midgut development (GO:0007494)2.24365314
113ganglion development (GO:0061548)2.24125040
114cellular protein complex localization (GO:0034629)2.23607362
115nucleotide-sugar biosynthetic process (GO:0009226)2.23448035
116retina vasculature morphogenesis in camera-type eye (GO:0061299)2.23149051
117regulation of SMAD protein import into nucleus (GO:0060390)2.22874524
118mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.22118987
119maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.21922255
120negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.21348229
121negative regulation of stem cell proliferation (GO:2000647)2.21063040
122artery development (GO:0060840)2.20906681
123heterochromatin organization (GO:0070828)2.20678371
124negative regulation of cardiac muscle tissue development (GO:0055026)2.20370067
125positive regulation of catenin import into nucleus (GO:0035413)2.20331427
126protein localization to kinetochore (GO:0034501)2.20291971
127regulation of plasminogen activation (GO:0010755)2.19848090
128protein complex localization (GO:0031503)2.19330233
129establishment of chromosome localization (GO:0051303)2.19285251
130chaperone-mediated protein complex assembly (GO:0051131)2.18247988
131kidney mesenchyme development (GO:0072074)2.17793602
132peptidyl-proline hydroxylation (GO:0019511)2.17626436
133regulation of mitotic spindle organization (GO:0060236)2.16604505
134DNA replication-dependent nucleosome organization (GO:0034723)2.16418680
135DNA replication-dependent nucleosome assembly (GO:0006335)2.16418680
136regulation of spindle organization (GO:0090224)2.15787290
137protein localization to cell surface (GO:0034394)2.15739284
138negative regulation of cell fate specification (GO:0009996)2.15015521
139chromosome condensation (GO:0030261)2.13864831
140regulation of centrosome cycle (GO:0046605)2.13378761
141single fertilization (GO:0007338)2.13069119
142cilium movement (GO:0003341)2.12320133
143bone trabecula formation (GO:0060346)2.12225341
144establishment of monopolar cell polarity (GO:0061162)2.11825206
145establishment or maintenance of monopolar cell polarity (GO:0061339)2.11825206
146protein hydroxylation (GO:0018126)2.11233254
147cell surface receptor signaling pathway involved in heart development (GO:0061311)2.11207382
148cell adhesion mediated by integrin (GO:0033627)2.09869154
149histone exchange (GO:0043486)2.09003071
150middle ear morphogenesis (GO:0042474)2.08426613
151Notch signaling involved in heart development (GO:0061314)2.08277231
152kinetochore organization (GO:0051383)2.07938868
153replicative senescence (GO:0090399)2.06166627
154positive regulation of male gonad development (GO:2000020)2.05705533
155microtubule depolymerization (GO:0007019)2.04690630
156mitotic nuclear envelope disassembly (GO:0007077)2.04214935
157lymphangiogenesis (GO:0001946)2.03554954
158chromatin remodeling at centromere (GO:0031055)2.01951920
159negative regulation of keratinocyte proliferation (GO:0010839)2.00650923
160morphogenesis of an epithelial sheet (GO:0002011)2.00647666
161positive regulation of actin filament depolymerization (GO:0030836)1.99702464
162regulation of endothelial cell differentiation (GO:0045601)1.99342418
163acrosome reaction (GO:0007340)1.99008862
164CENP-A containing nucleosome assembly (GO:0034080)1.97214461
165intraciliary transport (GO:0042073)1.97005395
166mitotic sister chromatid cohesion (GO:0007064)1.96812018
167motile cilium assembly (GO:0044458)1.96781665
168regulation of spindle checkpoint (GO:0090231)1.96711130
169monoubiquitinated protein deubiquitination (GO:0035520)1.96637748
170regulation of heart morphogenesis (GO:2000826)1.95976739
171myoblast migration (GO:0051451)1.95209972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.90387217
2E2F7_22180533_ChIP-Seq_HELA_Human4.44480925
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.68407021
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.66023502
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.60906905
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.56535832
7AR_21909140_ChIP-Seq_LNCAP_Human3.02013529
8CLOCK_20551151_ChIP-Seq_293T_Human2.81350724
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.66431932
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58436233
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37985673
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31282174
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28588540
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.27494873
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16146448
16SALL4_18804426_ChIP-ChIP_XEN_Mouse2.06694439
17CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.06589848
18POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02552017
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95096646
20EGR1_23403033_ChIP-Seq_LIVER_Mouse1.93064360
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89857322
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.89063311
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88785947
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86393846
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85279647
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81316876
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78720677
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.77418518
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74787232
30WT1_19549856_ChIP-ChIP_CCG9911_Human1.71418660
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67469041
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67423924
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67423924
34CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64550804
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62951545
36BRD4_25478319_ChIP-Seq_HGPS_Human1.62836254
37ELK1_19687146_ChIP-ChIP_HELA_Human1.55831293
38LXR_22158963_ChIP-Seq_LIVER_Mouse1.54854097
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54040667
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53990884
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48527658
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48175464
43CJUN_26792858_Chip-Seq_BT549_Human1.47852106
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47240970
45TP53_18474530_ChIP-ChIP_U2OS_Human1.42743600
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.42426272
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41980281
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41255275
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39765663
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38044143
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.36990742
52NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.34689871
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.33886474
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.33317189
55ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32244883
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.31068599
57SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30675946
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29261738
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25860997
60PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.23271499
61SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23078808
62SOX17_20123909_ChIP-Seq_XEN_Mouse1.21121013
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20911807
64ZNF263_19887448_ChIP-Seq_K562_Human1.20803692
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20677000
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19431004
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19367946
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19330041
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.18564007
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.18306569
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.15204714
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15049966
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12631574
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11047023
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10587122
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10525265
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.10070507
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09223982
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08956300
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08054781
81GATA4_25053715_ChIP-Seq_YYC3_Human1.07967266
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.07963380
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07566938
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07566938
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07566938
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06963073
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06600523
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06600523
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.04888548
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04630192
91NANOG_16153702_ChIP-ChIP_HESCs_Human1.04541173
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04521464
93TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04034933
94TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03705011
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.03338795
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02945386
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02178810
98MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02019869
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01895269
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01810948
101UBF1/2_26484160_Chip-Seq_HMECs_Human1.01584139
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00114980
103TP53_16413492_ChIP-PET_HCT116_Human0.98268126
104SOX2_20726797_ChIP-Seq_SW620_Human0.98234207
105TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98200581
106GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98196246
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96883862
108E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96500578
109MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96193168
110DCP1A_22483619_ChIP-Seq_HELA_Human0.95775155
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95286883
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95173254
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94682954
114ATF3_27146783_Chip-Seq_COLON_Human0.93310167
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93149483
116EOMES_21245162_ChIP-Seq_HESCs_Human0.92734014
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92699378
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91997921
119ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91615193
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91161383
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90996281
122CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90947359
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.90656943
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.89603256
125NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88450451
126FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88322094
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87915447
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87212831
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87017291
130PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86951633
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85598362
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85294560
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85179275
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84532586
135TP63_23658742_ChIP-Seq_EP156T_Human0.84429755
136CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84409171
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83915843
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.82681688
139TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81539361
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81294866
141STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79839087
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.79651412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.83711228
2MP0003705_abnormal_hypodermis_morpholog2.78218615
3MP0004272_abnormal_basement_membrane2.39028466
4MP0005275_abnormal_skin_tensile2.30195942
5MP0005503_abnormal_tendon_morphology2.28210580
6MP0005410_abnormal_fertilization2.20026693
7MP0010030_abnormal_orbit_morphology2.11645411
8MP0008007_abnormal_cellular_replicative2.04110594
9MP0010368_abnormal_lymphatic_system2.03469714
10MP0010234_abnormal_vibrissa_follicle2.03417882
11MP0009053_abnormal_anal_canal2.02187551
12MP0003941_abnormal_skin_development1.96773678
13MP0001879_abnormal_lymphatic_vessel1.90308528
14MP0001299_abnormal_eye_distance/1.86837829
15MP0009780_abnormal_chondrocyte_physiolo1.85188922
16MP0005623_abnormal_meninges_morphology1.82580166
17MP0003279_aneurysm1.77031474
18MP0005408_hypopigmentation1.73627463
19MP0002877_abnormal_melanocyte_morpholog1.66936115
20MP0003950_abnormal_plasma_membrane1.60029329
21MP0006054_spinal_hemorrhage1.56828821
22MP0003806_abnormal_nucleotide_metabolis1.56812572
23MP0003942_abnormal_urinary_system1.46460051
24MP0002139_abnormal_hepatobiliary_system1.44885365
25MP0003890_abnormal_embryonic-extraembry1.41895133
26MP0003385_abnormal_body_wall1.41565513
27MP0009384_cardiac_valve_regurgitation1.40801093
28MP0003186_abnormal_redox_activity1.34947366
29MP0004957_abnormal_blastocyst_morpholog1.34580319
30MP0009250_abnormal_appendicular_skeleto1.31702979
31MP0003566_abnormal_cell_adhesion1.29212981
32MP0002282_abnormal_trachea_morphology1.28115640
33MP0003091_abnormal_cell_migration1.27788032
34MP0000579_abnormal_nail_morphology1.26708172
35MP0002796_impaired_skin_barrier1.26394954
36MP0003937_abnormal_limbs/digits/tail_de1.24031252
37MP0005508_abnormal_skeleton_morphology1.23688558
38MP0000751_myopathy1.23391855
39MP0002060_abnormal_skin_morphology1.22956527
40MP0005023_abnormal_wound_healing1.19680082
41MP0003115_abnormal_respiratory_system1.17830952
42MP0000516_abnormal_urinary_system1.17438868
43MP0005367_renal/urinary_system_phenotyp1.17438868
44MP0002084_abnormal_developmental_patter1.15133096
45MP0005248_abnormal_Harderian_gland1.11742041
46MP0001849_ear_inflammation1.10485591
47MP0003786_premature_aging1.10421156
48MP0000049_abnormal_middle_ear1.06967153
49MP0002295_abnormal_pulmonary_circulatio1.05479803
50MP0010094_abnormal_chromosome_stability1.05479179
51MP0000566_synostosis1.04447392
52MP0002085_abnormal_embryonic_tissue1.02962502
53MP0002697_abnormal_eye_size1.02600148
54MP0010352_gastrointestinal_tract_polyps1.02390788
55MP0000767_abnormal_smooth_muscle1.02364282
56MP0004782_abnormal_surfactant_physiolog1.01205529
57MP0000467_abnormal_esophagus_morphology1.00748071
58MP0009697_abnormal_copulation0.99256328
59MP0002160_abnormal_reproductive_system0.97521836
60MP0001293_anophthalmia0.97516282
61MP0003195_calcinosis0.96999429
62MP0003755_abnormal_palate_morphology0.96912033
63MP0002254_reproductive_system_inflammat0.96893656
64MP0001915_intracranial_hemorrhage0.96375954
65MP0003123_paternal_imprinting0.96126092
66MP0004197_abnormal_fetal_growth/weight/0.95865416
67MP0001542_abnormal_bone_strength0.95213173
68MP0000432_abnormal_head_morphology0.94911503
69MP0003693_abnormal_embryo_hatching0.94865114
70MP0005501_abnormal_skin_physiology0.94457921
71MP0010307_abnormal_tumor_latency0.93633617
72MP0005670_abnormal_white_adipose0.92248285
73MP0003119_abnormal_digestive_system0.92130814
74MP0002653_abnormal_ependyma_morphology0.91761465
75MP0002168_other_aberrant_phenotype0.91435593
76MP0002233_abnormal_nose_morphology0.90720916
77MP0000013_abnormal_adipose_tissue0.89934722
78MP0003567_abnormal_fetal_cardiomyocyte0.89923891
79MP0001672_abnormal_embryogenesis/_devel0.89690687
80MP0005380_embryogenesis_phenotype0.89690687
81MP0000428_abnormal_craniofacial_morphol0.89685983
82MP0005257_abnormal_intraocular_pressure0.89448196
83MP0002092_abnormal_eye_morphology0.88825335
84MP0002111_abnormal_tail_morphology0.88765676
85MP0004233_abnormal_muscle_weight0.88765228
86MP0001958_emphysema0.88564978
87MP0002938_white_spotting0.88378259
88MP0003077_abnormal_cell_cycle0.88293518
89MP0000733_abnormal_muscle_development0.88031612
90MP0005076_abnormal_cell_differentiation0.87128796
91MP0000462_abnormal_digestive_system0.87017569
92MP0002009_preneoplasia0.86840021
93MP0000537_abnormal_urethra_morphology0.86500784
94MP0002088_abnormal_embryonic_growth/wei0.86021525
95MP0002108_abnormal_muscle_morphology0.85940993
96MP0000372_irregular_coat_pigmentation0.85058986
97MP0008057_abnormal_DNA_replication0.85048097
98MP0000749_muscle_degeneration0.84941910
99MP0001929_abnormal_gametogenesis0.84921919
100MP0010678_abnormal_skin_adnexa0.84737021
101MP0003984_embryonic_growth_retardation0.84695346
102MP0002210_abnormal_sex_determination0.84397103
103MP0002896_abnormal_bone_mineralization0.83992548
104MP0006138_congestive_heart_failure0.83585932
105MP0000163_abnormal_cartilage_morphology0.83160833
106MP0003453_abnormal_keratinocyte_physiol0.83044308
107MP0001661_extended_life_span0.82974142
108MP0001243_abnormal_dermal_layer0.81791579
109MP0002115_abnormal_skeleton_extremities0.81418928
110MP0005389_reproductive_system_phenotype0.81379771
111MP0003252_abnormal_bile_duct0.81070550
112MP0002086_abnormal_extraembryonic_tissu0.80987830
113MP0002234_abnormal_pharynx_morphology0.80568709
114MP0000762_abnormal_tongue_morphology0.80433765
115MP0008932_abnormal_embryonic_tissue0.80273847
116MP0000534_abnormal_ureter_morphology0.79437806
117MP0003283_abnormal_digestive_organ0.78336621
118MP0003935_abnormal_craniofacial_develop0.78075436
119MP0001697_abnormal_embryo_size0.76817158
120MP0002109_abnormal_limb_morphology0.75661847
121MP0002249_abnormal_larynx_morphology0.75358321
122MP0002925_abnormal_cardiovascular_devel0.75318444
123MP0001730_embryonic_growth_arrest0.75215335
124MP0005193_abnormal_anterior_eye0.74945237
125MP0003943_abnormal_hepatobiliary_system0.74678559
126MP0005197_abnormal_uvea_morphology0.74661610
127MP0004084_abnormal_cardiac_muscle0.74326197
128MP0001614_abnormal_blood_vessel0.73869295
129MP0001175_abnormal_lung_morphology0.73606839
130MP0002128_abnormal_blood_circulation0.73325168
131MP0001286_abnormal_eye_development0.72879704
132MP0003111_abnormal_nucleus_morphology0.72352493
133MP0009672_abnormal_birth_weight0.71864901

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.97543342
2Premature rupture of membranes (HP:0001788)3.80721255
3Protrusio acetabuli (HP:0003179)3.36177341
4Vascular tortuosity (HP:0004948)3.31258861
5Arterial tortuosity (HP:0005116)3.14053959
6Short nail (HP:0001799)3.01913075
7Abnormality of dentin (HP:0010299)2.84252680
8Spinal cord lesions (HP:0100561)2.79404113
9Syringomyelia (HP:0003396)2.79404113
10Soft skin (HP:0000977)2.75047684
11Absent/shortened dynein arms (HP:0200106)2.74114313
12Dynein arm defect of respiratory motile cilia (HP:0012255)2.74114313
13Selective tooth agenesis (HP:0001592)2.68693988
14Abnormality of the anterior horn cell (HP:0006802)2.68065572
15Degeneration of anterior horn cells (HP:0002398)2.68065572
16Coronal craniosynostosis (HP:0004440)2.64847800
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.53472790
18Osteolytic defects of the hand bones (HP:0009699)2.53472790
19Abnormal respiratory motile cilium physiology (HP:0012261)2.47277882
20Spinal rigidity (HP:0003306)2.44223694
21Hypoglycemic coma (HP:0001325)2.33938749
22Ankle contracture (HP:0006466)2.29434267
23Rhinitis (HP:0012384)2.28808160
24Pterygium (HP:0001059)2.27195861
25Broad metatarsal (HP:0001783)2.23358654
26Absent frontal sinuses (HP:0002688)2.22268614
27Abnormal respiratory motile cilium morphology (HP:0005938)2.17052478
28Abnormal respiratory epithelium morphology (HP:0012253)2.17052478
29Vertebral compression fractures (HP:0002953)2.16477922
30Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.16324499
31Wormian bones (HP:0002645)2.14717507
32Microglossia (HP:0000171)2.13636505
33Bell-shaped thorax (HP:0001591)2.11291405
3411 pairs of ribs (HP:0000878)2.11144455
35Abnormality of the distal phalanges of the toes (HP:0010182)2.09478209
36Chronic bronchitis (HP:0004469)2.08412583
37Abnormality of the acetabulum (HP:0003170)2.05517880
38Cardiovascular calcification (HP:0011915)2.04929139
39Abnormal lung lobation (HP:0002101)2.04605602
40Follicular hyperkeratosis (HP:0007502)2.02022423
41Biconcave vertebral bodies (HP:0004586)2.01774210
42Atrophic scars (HP:0001075)2.01693479
43Increased connective tissue (HP:0009025)2.00526858
44Embryonal renal neoplasm (HP:0011794)1.99546775
45Mitral valve prolapse (HP:0001634)1.95567482
46Ulnar bowing (HP:0003031)1.94150520
47Type 1 muscle fiber predominance (HP:0003803)1.93656958
48Abnormal delivery (HP:0001787)1.93628650
49Nephroblastoma (Wilms tumor) (HP:0002667)1.92573233
50Aortic dissection (HP:0002647)1.92338612
51Hypoalphalipoproteinemia (HP:0003233)1.91082393
52Myocardial infarction (HP:0001658)1.90421621
53Abnormality of carpal bone ossification (HP:0006257)1.89304430
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88554813
55Short 4th metacarpal (HP:0010044)1.88554813
56Abnormality of the frontal sinuses (HP:0002687)1.87990711
57Missing ribs (HP:0000921)1.85320972
58Hypoglycemic seizures (HP:0002173)1.85067881
59Renal duplication (HP:0000075)1.82662162
60Supernumerary spleens (HP:0009799)1.82392579
61Fibular hypoplasia (HP:0003038)1.82180403
62Cervical subluxation (HP:0003308)1.82071846
63Natal tooth (HP:0000695)1.81950242
64Vertebral clefting (HP:0008428)1.81154668
65Abnormality of the umbilical cord (HP:0010881)1.81033721
66Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80664924
67Wide anterior fontanel (HP:0000260)1.78126229
68Abnormality of the fetal cardiovascular system (HP:0010948)1.77072123
69Abnormal umbilical cord blood vessels (HP:0011403)1.77072123
70Single umbilical artery (HP:0001195)1.77072123
71Aortic aneurysm (HP:0004942)1.76960521
72Abnormal ossification of hand bones (HP:0005921)1.76476696
73Vascular calcification (HP:0004934)1.76233604
74Vertebral arch anomaly (HP:0008438)1.76080701
75Absent eyebrow (HP:0002223)1.75675236
76Blue sclerae (HP:0000592)1.74529109
77Rhizomelia (HP:0008905)1.74044655
78Mildly elevated creatine phosphokinase (HP:0008180)1.72257113
79Facial cleft (HP:0002006)1.71897542
80Impulsivity (HP:0100710)1.71526822
81Abnormal ciliary motility (HP:0012262)1.71014122
82Mesomelia (HP:0003027)1.70402810
83Enlarged kidneys (HP:0000105)1.70399898
84Absent eyelashes (HP:0000561)1.69748771
85Intrahepatic cholestasis (HP:0001406)1.69497215
86Abnormal hemoglobin (HP:0011902)1.69446763
87Tubular atrophy (HP:0000092)1.68794719
88Mitral stenosis (HP:0001718)1.68060986
89Joint laxity (HP:0001388)1.68015075
90Arnold-Chiari malformation (HP:0002308)1.67521364
91Bowel diverticulosis (HP:0005222)1.67115647
92Fragile skin (HP:0001030)1.66811143
93Short middle phalanx of the 5th finger (HP:0004220)1.65999635
94Hyperextensible skin (HP:0000974)1.65627355
95Bladder diverticulum (HP:0000015)1.64020617
96Esophageal varix (HP:0002040)1.63816703
97Subacute progressive viral hepatitis (HP:0006572)1.63660052
98Shallow orbits (HP:0000586)1.63605075
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.63441369
100Limited hip movement (HP:0008800)1.63264251
101Deviation of the thumb (HP:0009603)1.61836523
102Hypolipoproteinemia (HP:0010981)1.61499584
103Spastic diplegia (HP:0001264)1.61300199
104Abnormality of the phalanges of the hallux (HP:0010057)1.60612630
105Deep philtrum (HP:0002002)1.59494427
106Hyperinsulinemic hypoglycemia (HP:0000825)1.59391073
107Breech presentation (HP:0001623)1.59234542
108Abnormal hand bone ossification (HP:0010660)1.58028165
109Increased nuchal translucency (HP:0010880)1.56924726
110Protruding ear (HP:0000411)1.56546381
111Advanced eruption of teeth (HP:0006288)1.56310714
112Delayed cranial suture closure (HP:0000270)1.56201329
113Epidermoid cyst (HP:0200040)1.55676937
114Ankyloglossia (HP:0010296)1.55305038
115Hyperglycemia (HP:0003074)1.54249286
116Hepatocellular carcinoma (HP:0001402)1.54196756
117Knee flexion contracture (HP:0006380)1.54124665
118Right ventricular cardiomyopathy (HP:0011663)1.53563265
119Wrist flexion contracture (HP:0001239)1.53263124
120Cortical dysplasia (HP:0002539)1.53061746
121Bifid tongue (HP:0010297)1.52443089
122Short humerus (HP:0005792)1.52392122
123Abnormality of complement system (HP:0005339)1.52097382
124Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.49942524
125Dilatation of the ascending aorta (HP:0005111)1.49482678
126Overgrowth (HP:0001548)1.49360478
127Neonatal short-limb short stature (HP:0008921)1.48910238
128Fused cervical vertebrae (HP:0002949)1.48890825
129Abnormalities of placenta or umbilical cord (HP:0001194)1.48826506
130Pulmonary artery stenosis (HP:0004415)1.48737996
131Carpal synostosis (HP:0009702)1.48222690
132Abnormality of the renal cortex (HP:0011035)1.47980470
133Tubulointerstitial nephritis (HP:0001970)1.47431451
134Alveolar cell carcinoma (HP:0006519)1.46578750
135Myelomeningocele (HP:0002475)1.46107808
136Genu recurvatum (HP:0002816)1.46004574
137Stenosis of the external auditory canal (HP:0000402)1.45905939
138Cerebral aneurysm (HP:0004944)1.45384508
139Elbow flexion contracture (HP:0002987)1.45243456
140Mitral regurgitation (HP:0001653)1.45196626
141Asymmetry of the thorax (HP:0001555)1.43541257
142Camptodactyly of toe (HP:0001836)1.43505103
143Pancreatic islet-cell hyperplasia (HP:0004510)1.43405708
144Toxemia of pregnancy (HP:0100603)1.42610328
145Aplasia involving bones of the extremities (HP:0009825)1.42463780
146Aplasia involving bones of the upper limbs (HP:0009823)1.42463780
147Aplasia of the phalanges of the hand (HP:0009802)1.42463780
148Gonadotropin excess (HP:0000837)1.42336706
149Renal dysplasia (HP:0000110)1.42217363
150Abnormality of the 4th metacarpal (HP:0010012)1.42181326
151Aplasia/hypoplasia of the humerus (HP:0006507)1.42054840
152Hydroxyprolinuria (HP:0003080)1.41962200
153Alopecia of scalp (HP:0002293)1.41142894
154Omphalocele (HP:0001539)1.39530693
155Hydroureter (HP:0000072)1.39012964
156Flat acetabular roof (HP:0003180)1.38911307
157Abnormality of oral frenula (HP:0000190)1.38620257
158Abnormality of the calcaneus (HP:0008364)1.38489825
159Aplasia/Hypoplasia of the scapulae (HP:0006713)1.38314735
160Hypoplastic scapulae (HP:0000882)1.38314735
161Proximal placement of thumb (HP:0009623)1.38143962
162Ectopia lentis (HP:0001083)1.37831860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK42.86816227
2PDK32.86816227
3PDK22.82744760
4TESK12.73080396
5ZAK2.67542468
6NEK92.41881528
7PBK2.29908729
8STK38L2.26041858
9ERBB32.25359448
10LATS11.94354247
11NEK11.78599095
12STK31.76831654
13AKT31.75477069
14PASK1.73778496
15MKNK11.69187084
16FRK1.68975614
17EIF2AK21.66044797
18NUAK11.56572117
19MAP3K141.52233879
20TGFBR11.52138549
21BRSK21.51720391
22NTRK11.40389932
23EPHB21.39206594
24PLK41.37033742
25TRPM71.35461912
26FGFR11.34940812
27WEE11.27625369
28MAP3K31.27232585
29TTN1.27215366
30MET1.26206198
31PLK31.25869181
32PNCK1.25519009
33TAF11.25326223
34MAP3K121.20026190
35TSSK61.19003582
36TTK1.17425151
37CDK61.15927476
38MAP3K91.15817446
39RPS6KA41.13067794
40SRPK11.12927047
41NEK21.09906419
42PRKD31.08832650
43STK41.06880023
44DDR21.06407212
45CDC71.05319417
46YES11.05306052
47WNK41.04196780
48LIMK11.02918596
49EIF2AK11.01595510
50DMPK1.01149719
51DYRK1B1.00688006
52PTK60.98778822
53PAK40.96326958
54STK240.96054162
55MKNK20.93788924
56MAPK150.93557963
57PLK10.92761577
58OBSCN0.91839204
59STK100.91661222
60TRIM280.91268676
61BRSK10.89237081
62BCKDK0.88814575
63BUB10.87799625
64AURKB0.87582060
65BMPR1B0.86813170
66MOS0.86787602
67MST1R0.85799476
68RIPK10.84719039
69TIE10.82850185
70PDGFRA0.82482016
71PDGFRB0.81191755
72SCYL20.79495357
73TGFBR20.78150093
74CDK120.76449272
75EPHA20.76310165
76LMTK20.75923501
77MST40.75689231
78FLT30.74816530
79ICK0.74520705
80FER0.74098786
81BCR0.73286687
82KDR0.72847339
83ROCK20.72776771
84INSRR0.68977209
85SIK10.68959495
86CDK70.67413347
87CHUK0.67062756
88MAP3K80.64538399
89FGFR40.63499655
90PTK2B0.62305415
91EEF2K0.61562311
92MELK0.59999818
93ATR0.58753675
94ARAF0.58156798
95CDK80.57161985
96ERBB40.56206443
97STK380.56042102
98PIK3CG0.55965840
99ATM0.55583130
100STK390.55395629
101NEK60.55200790
102CHEK20.54764562
103PIM10.54323283
104PAK20.53975705
105EIF2AK30.53123540
106TNIK0.51841662
107BRD40.51251439
108PTK20.51073976
109MYLK0.50093016
110KSR10.49447219
111CDK90.48895802
112AURKA0.48823879
113ACVR1B0.48495607
114ILK0.48405066
115CAMK1G0.47564425
116TLK10.45879835
117PLK20.45825401
118MTOR0.44819471
119BRAF0.44478338
120CHEK10.44441433
121BMX0.42618867
122PAK30.41604423
123GSK3A0.40806358
124SGK20.40009063
125BMPR20.39901824
126MARK30.39798593
127ROCK10.39510585
128PKN20.39031280
129LATS20.38807042
130AKT20.38510036
131MAP3K100.37154304
132ABL20.35034037
133SMG10.33072829
134PRKCE0.32613344
135CDK180.30930214

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.27551713
2Selenocompound metabolism_Homo sapiens_hsa004502.18658486
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.93913807
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91258035
5Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86049911
6Fatty acid degradation_Homo sapiens_hsa000711.82522893
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79933426
8Sulfur metabolism_Homo sapiens_hsa009201.73807731
9Propanoate metabolism_Homo sapiens_hsa006401.72548554
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72084993
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59031512
12Chemical carcinogenesis_Homo sapiens_hsa052041.55324692
13Adherens junction_Homo sapiens_hsa045201.53884462
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53185952
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50799513
16Fatty acid metabolism_Homo sapiens_hsa012121.48740971
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.45682910
18Cell cycle_Homo sapiens_hsa041101.44801227
19Retinol metabolism_Homo sapiens_hsa008301.43234749
20ECM-receptor interaction_Homo sapiens_hsa045121.42032808
21TGF-beta signaling pathway_Homo sapiens_hsa043501.41629192
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35588393
23Complement and coagulation cascades_Homo sapiens_hsa046101.33966157
24PPAR signaling pathway_Homo sapiens_hsa033201.33195287
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31936946
26Systemic lupus erythematosus_Homo sapiens_hsa053221.31310683
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.31136836
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.30882930
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30794023
30Homologous recombination_Homo sapiens_hsa034401.30026673
31Steroid biosynthesis_Homo sapiens_hsa001001.29137656
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.26457582
33Glutathione metabolism_Homo sapiens_hsa004801.26344982
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25629056
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23899522
36RNA transport_Homo sapiens_hsa030131.23661926
37Basal transcription factors_Homo sapiens_hsa030221.19543190
38Protein digestion and absorption_Homo sapiens_hsa049741.18426908
39Fatty acid elongation_Homo sapiens_hsa000621.15710773
40Small cell lung cancer_Homo sapiens_hsa052221.15001443
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14042818
42Non-homologous end-joining_Homo sapiens_hsa034501.13651154
43Wnt signaling pathway_Homo sapiens_hsa043101.13647388
44Mismatch repair_Homo sapiens_hsa034301.13423090
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13045871
46Phenylalanine metabolism_Homo sapiens_hsa003601.11785244
47Legionellosis_Homo sapiens_hsa051341.11719334
48Vitamin B6 metabolism_Homo sapiens_hsa007501.11136123
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10833064
50Dilated cardiomyopathy_Homo sapiens_hsa054141.10832156
51Peroxisome_Homo sapiens_hsa041461.10661863
52Starch and sucrose metabolism_Homo sapiens_hsa005001.10496215
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.10114419
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07761350
55Hippo signaling pathway_Homo sapiens_hsa043901.07492143
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06879373
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.06557623
58Tyrosine metabolism_Homo sapiens_hsa003501.06460609
59DNA replication_Homo sapiens_hsa030301.02975262
60Fatty acid biosynthesis_Homo sapiens_hsa000611.02743239
61p53 signaling pathway_Homo sapiens_hsa041151.02363948
62Base excision repair_Homo sapiens_hsa034101.01934821
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01193267
64Protein export_Homo sapiens_hsa030601.00761877
65Folate biosynthesis_Homo sapiens_hsa007901.00076929
66Staphylococcus aureus infection_Homo sapiens_hsa051500.99213769
67Carbon metabolism_Homo sapiens_hsa012000.98960296
68Fanconi anemia pathway_Homo sapiens_hsa034600.97642708
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97175205
70Tryptophan metabolism_Homo sapiens_hsa003800.96310402
71Pyruvate metabolism_Homo sapiens_hsa006200.94670644
72Amoebiasis_Homo sapiens_hsa051460.92940954
73Focal adhesion_Homo sapiens_hsa045100.91625294
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88772693
75Axon guidance_Homo sapiens_hsa043600.88047369
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86877690
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86026502
78Arginine biosynthesis_Homo sapiens_hsa002200.85133843
79Basal cell carcinoma_Homo sapiens_hsa052170.84389166
80Nucleotide excision repair_Homo sapiens_hsa034200.83835644
81Proteasome_Homo sapiens_hsa030500.83257157
82Pathways in cancer_Homo sapiens_hsa052000.82104066
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82012528
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79608661
85Viral carcinogenesis_Homo sapiens_hsa052030.79128862
86Galactose metabolism_Homo sapiens_hsa000520.78962020
87MicroRNAs in cancer_Homo sapiens_hsa052060.78912569
88mRNA surveillance pathway_Homo sapiens_hsa030150.78619776
89Tight junction_Homo sapiens_hsa045300.78039320
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77878068
91Arachidonic acid metabolism_Homo sapiens_hsa005900.77400043
92Melanoma_Homo sapiens_hsa052180.76701751
93N-Glycan biosynthesis_Homo sapiens_hsa005100.76014366
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73048135
95Caffeine metabolism_Homo sapiens_hsa002320.72498317
96Proteoglycans in cancer_Homo sapiens_hsa052050.70967980
97Prostate cancer_Homo sapiens_hsa052150.69982000
98RNA degradation_Homo sapiens_hsa030180.69592469
99Melanogenesis_Homo sapiens_hsa049160.68745077
100Herpes simplex infection_Homo sapiens_hsa051680.67539050
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67259112
102Biosynthesis of amino acids_Homo sapiens_hsa012300.67194951
103Spliceosome_Homo sapiens_hsa030400.66479406
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64778540
105Lysine degradation_Homo sapiens_hsa003100.64712341
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64384399
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63619479
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.63114114
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62609114
110Oocyte meiosis_Homo sapiens_hsa041140.62315522
111Malaria_Homo sapiens_hsa051440.62113793
112Prion diseases_Homo sapiens_hsa050200.61682090
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58569278
114Thyroid cancer_Homo sapiens_hsa052160.56678427
115Pentose phosphate pathway_Homo sapiens_hsa000300.55562585
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55074839
117Histidine metabolism_Homo sapiens_hsa003400.54935896
118Vitamin digestion and absorption_Homo sapiens_hsa049770.54681604
119Sphingolipid metabolism_Homo sapiens_hsa006000.54063213
120HTLV-I infection_Homo sapiens_hsa051660.52895727
121Nitrogen metabolism_Homo sapiens_hsa009100.51675015
122Pyrimidine metabolism_Homo sapiens_hsa002400.51035158
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50797558
124beta-Alanine metabolism_Homo sapiens_hsa004100.50393567
125Gap junction_Homo sapiens_hsa045400.50226259
126Fat digestion and absorption_Homo sapiens_hsa049750.50083138
127Viral myocarditis_Homo sapiens_hsa054160.49916197
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.47626392
129Hedgehog signaling pathway_Homo sapiens_hsa043400.47240500
130Bladder cancer_Homo sapiens_hsa052190.46869950
131Endometrial cancer_Homo sapiens_hsa052130.46628241
132Renin-angiotensin system_Homo sapiens_hsa046140.46089923
133Antigen processing and presentation_Homo sapiens_hsa046120.45684089
134Colorectal cancer_Homo sapiens_hsa052100.45524625
135Arginine and proline metabolism_Homo sapiens_hsa003300.44860636
136Chronic myeloid leukemia_Homo sapiens_hsa052200.43466067

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