SEPT11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.63736144
2chondrocyte proliferation (GO:0035988)4.57005833
3metanephric mesenchyme development (GO:0072075)3.81747069
4paraxial mesoderm development (GO:0048339)3.70284580
5notochord development (GO:0030903)3.70162666
6kinetochore organization (GO:0051383)3.67745374
7kidney mesenchyme development (GO:0072074)3.63084422
8cell proliferation involved in metanephros development (GO:0072203)3.59909631
9nuclear pore complex assembly (GO:0051292)3.59612878
10cell proliferation involved in kidney development (GO:0072111)3.51436194
11negative regulation of axon extension involved in axon guidance (GO:0048843)3.45619762
12sequestering of extracellular ligand from receptor (GO:0035581)3.45321770
13nuclear pore organization (GO:0006999)3.44557614
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.36625631
15negative regulation of axon guidance (GO:1902668)3.33606492
16presynaptic membrane assembly (GO:0097105)3.24560728
17positive regulation of protein import into nucleus, translocation (GO:0033160)3.21201587
18cell migration involved in sprouting angiogenesis (GO:0002042)3.19249580
19cell migration involved in heart development (GO:0060973)3.18498981
20prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.15249341
21collagen fibril organization (GO:0030199)3.14589851
22axon extension involved in axon guidance (GO:0048846)3.14427510
23neuron projection extension involved in neuron projection guidance (GO:1902284)3.14427510
24negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.14276956
25regulation of axon extension involved in axon guidance (GO:0048841)3.10210617
26cell adhesion mediated by integrin (GO:0033627)3.10152511
27branching involved in prostate gland morphogenesis (GO:0060442)3.09508455
28pyrimidine nucleobase catabolic process (GO:0006208)3.07313198
29regulation of axon guidance (GO:1902667)3.06603107
30negative regulation of DNA repair (GO:0045738)3.06370446
31kinetochore assembly (GO:0051382)3.05758257
32hippo signaling (GO:0035329)3.02294859
33axon extension (GO:0048675)2.99887826
34retina vasculature morphogenesis in camera-type eye (GO:0061299)2.98239602
35cerebral cortex radially oriented cell migration (GO:0021799)2.97314700
36extracellular matrix assembly (GO:0085029)2.95148163
37lymph vessel development (GO:0001945)2.94451012
38mesenchymal cell proliferation (GO:0010463)2.93296789
39cochlea morphogenesis (GO:0090103)2.92676593
40neural crest cell development (GO:0014032)2.88825128
41glucocorticoid receptor signaling pathway (GO:0042921)2.88433206
42pore complex assembly (GO:0046931)2.87268307
43axonal fasciculation (GO:0007413)2.86305392
44lung vasculature development (GO:0060426)2.85569813
45negative regulation of stem cell proliferation (GO:2000647)2.83874231
46insulin-like growth factor receptor signaling pathway (GO:0048009)2.81833184
47skin morphogenesis (GO:0043589)2.79893026
48type B pancreatic cell proliferation (GO:0044342)2.77193898
49mitotic metaphase plate congression (GO:0007080)2.76365758
50lymphangiogenesis (GO:0001946)2.76242479
51positive regulation of male gonad development (GO:2000020)2.75979435
52negative chemotaxis (GO:0050919)2.74763608
53negative regulation of protein localization to cell surface (GO:2000009)2.74180248
54presynaptic membrane organization (GO:0097090)2.73622772
55extracellular fibril organization (GO:0043206)2.72751887
56negative regulation of androgen receptor signaling pathway (GO:0060766)2.72164914
57lateral sprouting from an epithelium (GO:0060601)2.71768935
58negative regulation of osteoblast proliferation (GO:0033689)2.71006007
59neuron recognition (GO:0008038)2.70292107
60DNA unwinding involved in DNA replication (GO:0006268)2.70089700
61sister chromatid segregation (GO:0000819)2.69291397
62membrane assembly (GO:0071709)2.68381375
63DNA topological change (GO:0006265)2.67951730
64establishment of tissue polarity (GO:0007164)2.67844913
65establishment of planar polarity (GO:0001736)2.67844913
66regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.67795801
67Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.67671016
68establishment of chromosome localization (GO:0051303)2.67126081
69mesenchymal-epithelial cell signaling (GO:0060638)2.65539552
70negative regulation of embryonic development (GO:0045992)2.65127374
71heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.64072262
72ganglion development (GO:0061548)2.63703306
73regulation of establishment of planar polarity (GO:0090175)2.63188175
74lung secretory cell differentiation (GO:0061140)2.61985624
75mammary gland development (GO:0030879)2.61970380
76chondrocyte development (GO:0002063)2.61144805
77collagen metabolic process (GO:0032963)2.60450547
78protein heterotrimerization (GO:0070208)2.59815285
79postsynaptic membrane organization (GO:0001941)2.59094134
80negative regulation of chondrocyte differentiation (GO:0032331)2.58883925
81bone trabecula formation (GO:0060346)2.58329367
82G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.57707965
83convergent extension (GO:0060026)2.57680016
84substrate adhesion-dependent cell spreading (GO:0034446)2.57488975
85central nervous system projection neuron axonogenesis (GO:0021952)2.57119356
86glomerulus development (GO:0032835)2.56791644
87metaphase plate congression (GO:0051310)2.56610747
88dermatan sulfate biosynthetic process (GO:0030208)2.55144088
89cellular response to vitamin (GO:0071295)2.52650024
90glomerular basement membrane development (GO:0032836)2.52419538
91collagen catabolic process (GO:0030574)2.51856233
92neuron projection extension (GO:1990138)2.50781684
93embryonic skeletal joint morphogenesis (GO:0060272)2.50718260
94smooth muscle tissue development (GO:0048745)2.50108236
95positive regulation of synapse assembly (GO:0051965)2.48910086
96epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.48876508
97craniofacial suture morphogenesis (GO:0097094)2.48810376
98protein localization to kinetochore (GO:0034501)2.48428475
99mesenchymal cell development (GO:0014031)2.48045184
100mitotic sister chromatid cohesion (GO:0007064)2.46550883
101regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.46382383
102regulation of mitotic spindle organization (GO:0060236)2.46183263
103adrenal gland development (GO:0030325)2.45216729
104mitotic G2/M transition checkpoint (GO:0044818)2.44994966
105regulation of centriole replication (GO:0046599)2.44206560
106corticosteroid receptor signaling pathway (GO:0031958)2.43826485
107blood vessel maturation (GO:0001955)2.42751178
108wound healing, spreading of epidermal cells (GO:0035313)2.42596924
109negative regulation of cartilage development (GO:0061037)2.42555651
110DNA replication checkpoint (GO:0000076)2.42342040
111multicellular organismal macromolecule metabolic process (GO:0044259)2.41314183
112non-canonical Wnt signaling pathway (GO:0035567)2.41235427
113outer ear morphogenesis (GO:0042473)2.40631050
114regulation of transforming growth factor beta2 production (GO:0032909)2.40147580
115negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.39817646
116mesodermal cell differentiation (GO:0048333)2.39008039
117regulation of integrin-mediated signaling pathway (GO:2001044)2.38122820
118regulation of chondrocyte differentiation (GO:0032330)2.38024947
119negative regulation of nitric-oxide synthase activity (GO:0051001)2.37931128
120regulation of non-canonical Wnt signaling pathway (GO:2000050)2.37576040
121cranial suture morphogenesis (GO:0060363)2.36603475
122heterochromatin organization (GO:0070828)2.36478921
123vascular endothelial growth factor signaling pathway (GO:0038084)2.36046141
124endodermal cell differentiation (GO:0035987)2.35754740
125midgut development (GO:0007494)2.35736881
126endocardial cushion development (GO:0003197)2.35110030
127negative regulation of BMP signaling pathway (GO:0030514)2.35054958
128negative regulation of smooth muscle cell migration (GO:0014912)2.34747199
129mitotic nuclear envelope disassembly (GO:0007077)2.34271329
130regulation of stem cell maintenance (GO:2000036)2.33979175
131dermatan sulfate metabolic process (GO:0030205)2.33281950
132protein localization to cell surface (GO:0034394)2.32848401
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.32546509
134regulation of spindle organization (GO:0090224)2.32436778
135lens morphogenesis in camera-type eye (GO:0002089)2.31799584
136regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.31767330
137CENP-A containing nucleosome assembly (GO:0034080)2.31644022
138cerebral cortex cell migration (GO:0021795)2.31499590
139positive regulation of SMAD protein import into nucleus (GO:0060391)2.30793023
140meiotic chromosome segregation (GO:0045132)2.30633585
141pericardium development (GO:0060039)2.30596711
142regulation of SMAD protein import into nucleus (GO:0060390)2.30092318
143regulation of double-strand break repair (GO:2000779)2.29025292
144histone-serine phosphorylation (GO:0035404)2.29007867
145artery development (GO:0060840)2.28668857
146heparan sulfate proteoglycan metabolic process (GO:0030201)2.28563351
147positive regulation of mitotic sister chromatid separation (GO:1901970)2.28407815
148positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.28407815
149positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.28407815
150anterior/posterior axis specification, embryo (GO:0008595)2.28367417
151positive regulation of cartilage development (GO:0061036)2.28005738
152positive regulation of cardiac muscle cell differentiation (GO:2000727)2.27520181
153mitotic sister chromatid segregation (GO:0000070)2.26900270
154multicellular organismal metabolic process (GO:0044236)2.26679711
155dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.26667205
156endothelial cell morphogenesis (GO:0001886)2.26666924
157multicellular organismal catabolic process (GO:0044243)2.26072066
158mesenchymal cell differentiation involved in renal system development (GO:2001012)2.25544079
159mesenchymal cell differentiation involved in kidney development (GO:0072161)2.25544079
160regulation of male gonad development (GO:2000018)2.25436049
161regulation of cellular senescence (GO:2000772)2.24037456
162kidney morphogenesis (GO:0060993)2.23753562
163DNA double-strand break processing (GO:0000729)2.23650909
164substrate-dependent cell migration (GO:0006929)2.23558374
165spindle checkpoint (GO:0031577)2.23523606
166regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.23049525
167metanephros development (GO:0001656)2.22658224
168regulation of centrosome duplication (GO:0010824)2.21886535
169regulation of mitotic metaphase/anaphase transition (GO:0030071)2.21220616
170nuclear envelope disassembly (GO:0051081)2.21179114
171membrane disassembly (GO:0030397)2.21179114
172mitotic recombination (GO:0006312)2.21051511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.37016557
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.18640990
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.22952065
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.20027524
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14931955
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.13471466
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.03920581
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.97388998
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.87812074
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.84641923
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.69326912
12GBX2_23144817_ChIP-Seq_PC3_Human2.67306871
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45670879
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31764697
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22847254
16EZH2_22144423_ChIP-Seq_EOC_Human2.20357982
17AR_21909140_ChIP-Seq_LNCAP_Human2.20205520
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.19554707
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.05931799
20ELK1_19687146_ChIP-ChIP_HELA_Human2.01636423
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.00607008
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.92371941
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.91392032
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88814202
25BRD4_25478319_ChIP-Seq_HGPS_Human1.85138749
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84081787
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.83135677
28EWS_26573619_Chip-Seq_HEK293_Human1.79661666
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.75866910
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75687756
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73319769
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72763103
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72300946
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.69507375
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.69472632
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69057356
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68909291
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.68757461
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66433535
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66433535
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66408047
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63649616
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59530307
44CJUN_26792858_Chip-Seq_BT549_Human1.58883658
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.58131826
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57926646
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56630058
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.56495810
49TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.55528048
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55389619
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54531700
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51855233
53SMAD4_21799915_ChIP-Seq_A2780_Human1.51709214
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48646041
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48444819
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45319823
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41532952
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.41475560
59TBX3_20139965_ChIP-Seq_MESCs_Mouse1.39595421
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.39486745
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39168117
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38154814
63KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.38135089
64FUS_26573619_Chip-Seq_HEK293_Human1.37068493
65TAF15_26573619_Chip-Seq_HEK293_Human1.36132827
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35573120
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34658771
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32874342
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32041829
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31848494
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31842547
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31824657
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.31417238
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30878882
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30090212
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29918773
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27625736
78TP53_18474530_ChIP-ChIP_U2OS_Human1.27140781
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25422711
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.24639522
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24337074
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24337074
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23737966
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.22702179
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21496152
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20701492
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20605557
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19234891
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18133495
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17490298
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16942893
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.16125826
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.15401612
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15313207
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14277784
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14071648
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.13433982
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12273023
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11783771
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10491952
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10441035
102RNF2_27304074_Chip-Seq_NSC_Mouse1.09713779
103JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08855813
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08817123
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08326615
106MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07644135
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06393620
108PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06245191
109MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04941174
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.03706724
111NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02694557
112NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02694557
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02519508
114SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01711009
115STAT3_23295773_ChIP-Seq_U87_Human1.01108782
116GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00853408
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00749397
118KDM2B_26808549_Chip-Seq_REH_Human1.00241376
119POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99879723
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99541176
121RING1B_27294783_Chip-Seq_ESCs_Mouse0.98186969
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97834238
123MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97364611
124MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97145672
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96877579
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96291880
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95814731
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95715842
129CLOCK_20551151_ChIP-Seq_293T_Human0.94499245
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.90488537
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90233185
132NANOG_21062744_ChIP-ChIP_HESCs_Human0.88623598
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88098337
134JUN_21703547_ChIP-Seq_K562_Human0.87938799
135CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87902748
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.86674825
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.85961767
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85312479
139TCF4_18268006_ChIP-ChIP_LS174T_Human0.84347776
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84116132
141EED_16625203_ChIP-ChIP_MESCs_Mouse0.83924190
142ISL1_27105846_Chip-Seq_CPCs_Mouse0.82108045
143TP53_20018659_ChIP-ChIP_R1E_Mouse0.81537233
144ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81168501
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79956243
146SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79912114
147TP53_16413492_ChIP-PET_HCT116_Human0.79565453
148POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79466251
149SOX9_26525672_Chip-Seq_HEART_Mouse0.79069614
150POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78708227
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78150557
152NFI_21473784_ChIP-Seq_ESCs_Mouse0.78022190
153CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.76058971
154TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75312652
155P300_19829295_ChIP-Seq_ESCs_Human0.74580148

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.96156469
2MP0003123_paternal_imprinting3.83314945
3MP0005503_abnormal_tendon_morphology3.64783906
4MP0003121_genomic_imprinting2.89706318
5MP0003122_maternal_imprinting2.72187290
6MP0003705_abnormal_hypodermis_morpholog2.69812709
7MP0003385_abnormal_body_wall2.69107260
8MP0010030_abnormal_orbit_morphology2.66961699
9MP0003787_abnormal_imprinting2.52337074
10MP0005275_abnormal_skin_tensile2.38340686
11MP0009053_abnormal_anal_canal2.34664154
12MP0003279_aneurysm2.31747348
13MP0003942_abnormal_urinary_system2.11966878
14MP0001879_abnormal_lymphatic_vessel2.06312434
15MP0009697_abnormal_copulation1.91961235
16MP0005367_renal/urinary_system_phenotyp1.83450225
17MP0000516_abnormal_urinary_system1.83450225
18MP0009250_abnormal_appendicular_skeleto1.82928939
19MP0004272_abnormal_basement_membrane1.82885770
20MP0000566_synostosis1.79525557
21MP0002282_abnormal_trachea_morphology1.71276031
22MP0008057_abnormal_DNA_replication1.69369002
23MP0008007_abnormal_cellular_replicative1.66064275
24MP0003755_abnormal_palate_morphology1.63779880
25MP0005508_abnormal_skeleton_morphology1.63711229
26MP0006054_spinal_hemorrhage1.62703995
27MP0003115_abnormal_respiratory_system1.62438741
28MP0010368_abnormal_lymphatic_system1.61763654
29MP0010094_abnormal_chromosome_stability1.61619301
30MP0005076_abnormal_cell_differentiation1.61050169
31MP0002938_white_spotting1.61048416
32MP0010352_gastrointestinal_tract_polyps1.58461942
33MP0005623_abnormal_meninges_morphology1.58101425
34MP0000778_abnormal_nervous_system1.58016762
35MP0001958_emphysema1.54740757
36MP0000049_abnormal_middle_ear1.47042094
37MP0004197_abnormal_fetal_growth/weight/1.44673825
38MP0003941_abnormal_skin_development1.42080508
39MP0003111_abnormal_nucleus_morphology1.41827132
40MP0009780_abnormal_chondrocyte_physiolo1.40206759
41MP0003077_abnormal_cell_cycle1.40148811
42MP0000767_abnormal_smooth_muscle1.37053423
43MP0009384_cardiac_valve_regurgitation1.36668089
44MP0003283_abnormal_digestive_organ1.35943642
45MP0003937_abnormal_limbs/digits/tail_de1.35489299
46MP0000569_abnormal_digit_pigmentation1.34242479
47MP0000537_abnormal_urethra_morphology1.32631383
48MP0000428_abnormal_craniofacial_morphol1.32143372
49MP0003315_abnormal_perineum_morphology1.30457887
50MP0000534_abnormal_ureter_morphology1.29433937
51MP0003119_abnormal_digestive_system1.29395892
52MP0002108_abnormal_muscle_morphology1.28285868
53MP0005248_abnormal_Harderian_gland1.26008252
54MP0002697_abnormal_eye_size1.22601466
55MP0000751_myopathy1.22014619
56MP0004134_abnormal_chest_morphology1.21534314
57MP0000762_abnormal_tongue_morphology1.20964628
58MP0001177_atelectasis1.20953840
59MP0002896_abnormal_bone_mineralization1.18453731
60MP0005187_abnormal_penis_morphology1.18317309
61MP0002109_abnormal_limb_morphology1.18177442
62MP0001529_abnormal_vocalization1.17873820
63MP0000432_abnormal_head_morphology1.16754149
64MP0003693_abnormal_embryo_hatching1.14895948
65MP0002116_abnormal_craniofacial_bone1.14084012
66MP0003935_abnormal_craniofacial_develop1.13982073
67MP0004859_abnormal_synaptic_plasticity1.12598392
68MP0000163_abnormal_cartilage_morphology1.12520790
69MP0002932_abnormal_joint_morphology1.12061755
70MP0002115_abnormal_skeleton_extremities1.11414764
71MP0004957_abnormal_blastocyst_morpholog1.10679232
72MP0008932_abnormal_embryonic_tissue1.10288510
73MP0000733_abnormal_muscle_development1.09997347
74MP0001542_abnormal_bone_strength1.09770658
75MP0008058_abnormal_DNA_repair1.09636928
76MP0003566_abnormal_cell_adhesion1.09085838
77MP0002249_abnormal_larynx_morphology1.05683946
78MP0005171_absent_coat_pigmentation1.05369169
79MP0008789_abnormal_olfactory_epithelium1.04126885
80MP0002088_abnormal_embryonic_growth/wei1.03819724
81MP0004858_abnormal_nervous_system1.03459269
82MP0005023_abnormal_wound_healing1.02805801
83MP0001672_abnormal_embryogenesis/_devel1.02792358
84MP0005380_embryogenesis_phenotype1.02792358
85MP0000350_abnormal_cell_proliferation1.02627652
86MP0003567_abnormal_fetal_cardiomyocyte1.02426162
87MP0003943_abnormal_hepatobiliary_system1.02189361
88MP0003984_embryonic_growth_retardation1.02098412
89MP0002113_abnormal_skeleton_development1.01871184
90MP0005257_abnormal_intraocular_pressure1.01108916
91MP0002234_abnormal_pharynx_morphology1.00472623
92MP0005595_abnormal_vascular_smooth1.00060895
93MP0002751_abnormal_autonomic_nervous0.99597580
94MP0001299_abnormal_eye_distance/0.98833089
95MP0005197_abnormal_uvea_morphology0.98228423
96MP0001175_abnormal_lung_morphology0.96859879
97MP0002102_abnormal_ear_morphology0.95118670
98MP0002163_abnormal_gland_morphology0.94372178
99MP0002092_abnormal_eye_morphology0.93752881
100MP0002111_abnormal_tail_morphology0.91974558
101MP0002925_abnormal_cardiovascular_devel0.91935955
102MP0001915_intracranial_hemorrhage0.90931988
103MP0001286_abnormal_eye_development0.90797020
104MP0002177_abnormal_outer_ear0.90671398
105MP0002085_abnormal_embryonic_tissue0.89759275
106MP0002233_abnormal_nose_morphology0.89233947
107MP0006292_abnormal_olfactory_placode0.88672454
108MP0003091_abnormal_cell_migration0.88323160
109MP0002009_preneoplasia0.88099997
110MP0003861_abnormal_nervous_system0.88087462
111MP0002086_abnormal_extraembryonic_tissu0.87767434
112MP0002114_abnormal_axial_skeleton0.86886382
113MP0003448_altered_tumor_morphology0.86731276
114MP0001293_anophthalmia0.86157652
115MP0001697_abnormal_embryo_size0.84811365
116MP0005390_skeleton_phenotype0.83844911
117MP0002060_abnormal_skin_morphology0.83801915
118MP0001243_abnormal_dermal_layer0.83578095
119MP0009703_decreased_birth_body0.83252606
120MP0000462_abnormal_digestive_system0.82162806
121MP0002295_abnormal_pulmonary_circulatio0.81213818
122MP0004270_analgesia0.80825026
123MP0003950_abnormal_plasma_membrane0.80328964
124MP0000013_abnormal_adipose_tissue0.79521927
125MP0002084_abnormal_developmental_patter0.79038357
126MP0010386_abnormal_urinary_bladder0.78776021
127MP0005499_abnormal_olfactory_system0.78218279
128MP0005394_taste/olfaction_phenotype0.78218279
129MP0002081_perinatal_lethality0.76225044
130MP0003890_abnormal_embryonic-extraembry0.73252286
131MP0000749_muscle_degeneration0.72506136
132MP0002128_abnormal_blood_circulation0.72233458
133MP0002184_abnormal_innervation0.70475424
134MP0000955_abnormal_spinal_cord0.67390664

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)4.30421937
2Syringomyelia (HP:0003396)4.12122985
3Spinal cord lesions (HP:0100561)4.12122985
4Short 4th metacarpal (HP:0010044)3.76392775
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.76392775
6Arterial tortuosity (HP:0005116)3.69686494
7Diastasis recti (HP:0001540)3.45590102
8Aortic aneurysm (HP:0004942)3.27542979
9Atrophic scars (HP:0001075)3.22741958
10Broad metatarsal (HP:0001783)3.21815706
11Follicular hyperkeratosis (HP:0007502)3.15494653
12Protrusio acetabuli (HP:0003179)3.14173829
13Coronal craniosynostosis (HP:0004440)3.13131621
14Wide anterior fontanel (HP:0000260)2.97914495
15Genu recurvatum (HP:0002816)2.91229357
16Neoplasm of the adrenal cortex (HP:0100641)2.86968167
17Mesomelia (HP:0003027)2.85140010
18Metaphyseal dysplasia (HP:0100255)2.82633395
19Embryonal renal neoplasm (HP:0011794)2.79475202
20Abnormality of the 4th metacarpal (HP:0010012)2.77478503
21Nephroblastoma (Wilms tumor) (HP:0002667)2.76576546
22Premature rupture of membranes (HP:0001788)2.72839709
23Abnormality of incisor morphology (HP:0011063)2.71991014
24Vascular tortuosity (HP:0004948)2.61240479
25Mild short stature (HP:0003502)2.52987491
26Overgrowth (HP:0001548)2.51928154
27Asymmetry of the thorax (HP:0001555)2.51031161
28Type 1 muscle fiber predominance (HP:0003803)2.48803464
29Mitral valve prolapse (HP:0001634)2.48683667
30Deep philtrum (HP:0002002)2.46023226
31Shallow orbits (HP:0000586)2.45748862
32Fragile skin (HP:0001030)2.44922063
33Abnormality of the distal phalanx of the thumb (HP:0009617)2.39560596
34Slender build (HP:0001533)2.38402547
35Wormian bones (HP:0002645)2.37247448
36Renal duplication (HP:0000075)2.35294467
37Broad thumb (HP:0011304)2.35279154
38Hyperextensible skin (HP:0000974)2.32604175
39Epiphyseal dysplasia (HP:0002656)2.31454396
40Aortic regurgitation (HP:0001659)2.31100349
41Short middle phalanx of the 5th finger (HP:0004220)2.29680674
42Neonatal short-limb short stature (HP:0008921)2.29655579
43Broad long bones (HP:0005622)2.27802545
44Broad phalanx (HP:0006009)2.24746371
45Adrenal hypoplasia (HP:0000835)2.24690021
46Dilatation of the ascending aorta (HP:0005111)2.20958820
47Abnormality of the nasal septum (HP:0000419)2.20680251
48Broad finger (HP:0001500)2.19212536
49Broad phalanges of the hand (HP:0009768)2.18716748
50Increased number of teeth (HP:0011069)2.12571418
51Abnormality of the incisor (HP:0000676)2.12420282
52Soft skin (HP:0000977)2.12387854
53Spondylolisthesis (HP:0003302)2.11348043
54Bladder diverticulum (HP:0000015)2.07336386
55Abnormality of the ischium (HP:0003174)2.06245977
56Morphological abnormality of the middle ear (HP:0008609)2.06168544
57Cervical subluxation (HP:0003308)2.06090828
58Camptodactyly of toe (HP:0001836)2.04473850
59Mitral regurgitation (HP:0001653)2.04293388
60Trigonocephaly (HP:0000243)2.03681250
61Breech presentation (HP:0001623)2.03645136
62Aortic dissection (HP:0002647)1.99749202
63Abnormality of the phalanges of the hallux (HP:0010057)1.99719493
64Broad toe (HP:0001837)1.98387233
65Hypoventilation (HP:0002791)1.97917930
66Limited hip movement (HP:0008800)1.97515686
67Absent frontal sinuses (HP:0002688)1.96673847
68Dislocated radial head (HP:0003083)1.96629264
69Cortical dysplasia (HP:0002539)1.96181330
70Abnormal delivery (HP:0001787)1.95171423
71Abnormality of dentin (HP:0010299)1.94647315
72Infantile muscular hypotonia (HP:0008947)1.93961620
73Short 5th finger (HP:0009237)1.91849624
74Ulnar bowing (HP:0003031)1.90687989
75Deviation of the hallux (HP:0010051)1.90590437
76Biconcave vertebral bodies (HP:0004586)1.90462361
77Long clavicles (HP:0000890)1.90172384
78Spinal rigidity (HP:0003306)1.88025898
79Vitreoretinal degeneration (HP:0000655)1.87532869
80Abnormality of the radial head (HP:0003995)1.86332788
81Natal tooth (HP:0000695)1.85537389
82Broad palm (HP:0001169)1.85256139
83Patellar aplasia (HP:0006443)1.83323524
84Ectopia lentis (HP:0001083)1.83149026
85Broad ribs (HP:0000885)1.82662862
86Abnormal number of incisors (HP:0011064)1.82277059
87Peritonitis (HP:0002586)1.80743079
88Ectopic kidney (HP:0000086)1.79895409
89Ankle contracture (HP:0006466)1.79004370
90Hallux valgus (HP:0001822)1.78943945
91Delayed gross motor development (HP:0002194)1.77943470
92Increased corneal curvature (HP:0100692)1.77886609
93Keratoconus (HP:0000563)1.77886609
94Long palpebral fissure (HP:0000637)1.77428345
95Wrist flexion contracture (HP:0001239)1.76417034
96Thin ribs (HP:0000883)1.76335380
97Hypoplastic ischia (HP:0003175)1.75843558
98Blue sclerae (HP:0000592)1.75838851
99Pulmonary artery stenosis (HP:0004415)1.75523635
100Deviation of the thumb (HP:0009603)1.75260852
101Protruding ear (HP:0000411)1.74989298
102Pulmonic stenosis (HP:0001642)1.74741472
103Limb-girdle muscle weakness (HP:0003325)1.74696949
104Microglossia (HP:0000171)1.73639596
105Abnormality of the metopic suture (HP:0005556)1.72964646
106Flat cornea (HP:0007720)1.72556050
107Vertebral compression fractures (HP:0002953)1.72128515
108Irregular epiphyses (HP:0010582)1.71306696
109Hypoplasia of the iris (HP:0007676)1.70790581
110Aplasia/Hypoplasia of the patella (HP:0006498)1.70517823
111Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.70343200
112Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.70185110
113Heterochromia iridis (HP:0001100)1.69344577
114Abnormality of the acetabulum (HP:0003170)1.69257741
115Long eyelashes (HP:0000527)1.69227708
116Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.68333743
117Flat capital femoral epiphysis (HP:0003370)1.67867143
118Inguinal hernia (HP:0000023)1.66236413
119Abnormality of the calcaneus (HP:0008364)1.66175061
120Abnormality of the parietal bone (HP:0002696)1.65368999
121Omphalocele (HP:0001539)1.63028206
122Knee flexion contracture (HP:0006380)1.62700423
123Flared iliac wings (HP:0002869)1.62526485
124Vertebral arch anomaly (HP:0008438)1.62133312
125Deformed tarsal bones (HP:0008119)1.61706739
126Aortic valve stenosis (HP:0001650)1.60933554
127Carpal synostosis (HP:0009702)1.60590134
128Arnold-Chiari malformation (HP:0002308)1.60265337
129Mildly elevated creatine phosphokinase (HP:0008180)1.59963007
130Abnormality of the intervertebral disk (HP:0005108)1.59512941
131Decreased skull ossification (HP:0004331)1.59458281
132Abnormal lung lobation (HP:0002101)1.59411375
133Calcaneovalgus deformity (HP:0001848)1.58557278
134Bowel diverticulosis (HP:0005222)1.58285497
135Subacute progressive viral hepatitis (HP:0006572)1.58032027
136Midline defect of the nose (HP:0004122)1.57838089
137Turricephaly (HP:0000262)1.56394749
138Meckel diverticulum (HP:0002245)1.56348552
139Abnormality of the anterior horn cell (HP:0006802)1.55704798
140Degeneration of anterior horn cells (HP:0002398)1.55704798
141Abnormality of the phalanges of the 5th finger (HP:0004213)1.55035990
142Joint laxity (HP:0001388)1.54927604
143Abnormality of the anterior chamber (HP:0000593)1.54491659
144Bifid tongue (HP:0010297)1.54232890
145Disproportionate tall stature (HP:0001519)1.53788479
146Selective tooth agenesis (HP:0001592)1.53623645
147Tibial bowing (HP:0002982)1.53165460
148Missing ribs (HP:0000921)1.52192698
149Abnormality of the proximal phalanges of the hand (HP:0009834)1.51985516
150Preaxial foot polydactyly (HP:0001841)1.51408101
151Abnormal ossification of hand bones (HP:0005921)1.50603807
152Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.49885143
153Osteoarthritis (HP:0002758)1.49645415
154Optic nerve coloboma (HP:0000588)1.48693877
155Cerebral aneurysm (HP:0004944)1.48439159
156Hip contracture (HP:0003273)1.47813074
157Partial duplication of the phalanx of hand (HP:0009999)1.45320811
158Cutaneous finger syndactyly (HP:0010554)1.43975743
159Delayed cranial suture closure (HP:0000270)1.42360482
160Increased variability in muscle fiber diameter (HP:0003557)1.41897954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB34.10411177
2MARK13.05366777
3ZAK3.02639066
4LATS12.78159715
5MKNK12.76604246
6NTRK12.66188970
7PLK22.65384042
8CDC72.65359285
9PNCK2.59086457
10STK38L2.55436626
11NUAK12.50570069
12PLK32.42552725
13MKNK22.27799034
14EIF2AK12.23346825
15SIK32.19909547
16AKT32.14716999
17CDK122.07875979
18DDR22.00118765
19SRPK11.94691870
20EPHB21.92810573
21MAP3K141.84352929
22STK31.82912802
23PLK41.80945921
24LATS21.71368375
25TRPM71.66885877
26FRK1.65040859
27TNIK1.63811533
28PTK21.63450968
29MOS1.49521339
30STK241.44380674
31ROCK21.42751202
32TGFBR11.39857780
33PAK61.38478387
34NEK11.37783955
35BMPR21.37159769
36CLK11.37057305
37EIF2AK31.35771483
38YES11.30428560
39WNK31.24870557
40TESK11.23545398
41MET1.22855839
42PDGFRA1.21769004
43PLK11.19172049
44NTRK21.16395811
45EIF2AK21.16342839
46CHEK21.15279807
47PASK1.13103101
48DYRK21.11290536
49NEK91.11251900
50LIMK11.08785834
51BCR1.07720872
52RPS6KA41.07586625
53EPHA31.06771334
54PBK1.06391029
55BUB11.05475155
56EPHA41.03697633
57MAP3K41.01022303
58FLT30.98763344
59ATR0.97842967
60MAPK130.95588581
61TTN0.94890098
62PAK20.92751276
63TSSK60.92286186
64CHUK0.88627512
65TRIM280.88499807
66PIM10.88008615
67MELK0.87119321
68CDK80.86427132
69TTK0.86261689
70KSR10.84008498
71JAK30.83769024
72BRSK20.83327602
73MAP2K70.83022546
74PIK3CA0.81180978
75SGK20.80972815
76CHEK10.80440385
77AURKB0.80140506
78CSNK1G20.78972281
79CDK150.76952051
80FGFR10.76832029
81NEK20.76192045
82CDK140.75312018
83PRKCE0.75130601
84CDK70.74268423
85ROCK10.73256322
86MUSK0.73247498
87CDK11A0.71095002
88ATM0.70726314
89CASK0.70690722
90BRD40.70650653
91TAF10.70214161
92PRPF4B0.69866076
93ACVR1B0.69861123
94CSNK1G10.69565487
95CAMK1G0.69070037
96BRSK10.68709793
97ADRBK10.68148882
98CSNK1A1L0.67752301
99STK390.67279598
100NEK60.67225532
101STK380.65444633
102GSK3A0.64244203
103WEE10.62821913
104MINK10.62782614
105VRK10.62359736
106TGFBR20.61646338
107MYLK0.61491136
108TAOK20.59470858
109PRKCG0.59088588
110STK40.58996308
111CDK10.56245238
112MAP3K100.55562721
113BMX0.55196757
114BMPR1B0.54216213
115PIK3CG0.54206517
116ERBB40.54047035
117CDK20.53018693
118DMPK0.52161812
119PRKD30.52078153
120TIE10.51665891
121CSNK1G30.51537970
122PRKD20.51236507
123MAP4K20.51033289
124PAK30.50684368
125SGK30.49865325
126RPS6KB10.49586875
127ILK0.49353650
128PAK40.47072941
129STK100.47034262
130CDK60.46866056
131SCYL20.46214997
132FER0.45704236
133PIM20.45220258
134CDK180.43810663
135CAMK2B0.43184342
136MAP3K120.41808859
137CCNB10.41038839
138PTK2B0.40257239
139DYRK1B0.40147410
140WNK10.39915458
141CSNK2A10.38507632
142MTOR0.38130071
143AKT10.37773828
144PDGFRB0.37185402
145MAP3K30.35275573
146RPS6KC10.34842764
147RPS6KL10.34842764
148CAMK2D0.33800372
149CDK50.33513000

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.47873491
2DNA replication_Homo sapiens_hsa030302.30518320
3Mismatch repair_Homo sapiens_hsa034302.14422108
4TGF-beta signaling pathway_Homo sapiens_hsa043502.01061332
5Adherens junction_Homo sapiens_hsa045201.97722485
6Base excision repair_Homo sapiens_hsa034101.93907663
7Hippo signaling pathway_Homo sapiens_hsa043901.87573509
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82971910
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75492423
10MicroRNAs in cancer_Homo sapiens_hsa052061.71840500
11RNA transport_Homo sapiens_hsa030131.71055602
12Steroid biosynthesis_Homo sapiens_hsa001001.70975921
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67943547
14Focal adhesion_Homo sapiens_hsa045101.63871745
15ECM-receptor interaction_Homo sapiens_hsa045121.63344555
16p53 signaling pathway_Homo sapiens_hsa041151.61540241
17Basal cell carcinoma_Homo sapiens_hsa052171.54909136
18Viral myocarditis_Homo sapiens_hsa054161.54488541
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.53940484
20One carbon pool by folate_Homo sapiens_hsa006701.53735942
21Spliceosome_Homo sapiens_hsa030401.53556696
22Gap junction_Homo sapiens_hsa045401.49170817
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47472162
24Homologous recombination_Homo sapiens_hsa034401.45940483
25* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.45847465
26Proteoglycans in cancer_Homo sapiens_hsa052051.45617381
27mRNA surveillance pathway_Homo sapiens_hsa030151.44400440
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44059835
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43024379
30Cocaine addiction_Homo sapiens_hsa050301.39571008
31Nucleotide excision repair_Homo sapiens_hsa034201.35859284
32Melanoma_Homo sapiens_hsa052181.32668339
33Melanogenesis_Homo sapiens_hsa049161.31765372
34Prostate cancer_Homo sapiens_hsa052151.30811082
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30207684
36RNA degradation_Homo sapiens_hsa030181.29897270
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26528188
38Small cell lung cancer_Homo sapiens_hsa052221.24663576
39HTLV-I infection_Homo sapiens_hsa051661.23434813
40Fanconi anemia pathway_Homo sapiens_hsa034601.22684914
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20997379
42Hedgehog signaling pathway_Homo sapiens_hsa043401.19032823
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16426504
44Proteasome_Homo sapiens_hsa030501.16049322
45Legionellosis_Homo sapiens_hsa051341.12447182
46Dilated cardiomyopathy_Homo sapiens_hsa054141.10684829
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10290972
48Colorectal cancer_Homo sapiens_hsa052101.10249901
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07108926
50Malaria_Homo sapiens_hsa051441.06747634
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03626908
52Chronic myeloid leukemia_Homo sapiens_hsa052200.99733357
53Shigellosis_Homo sapiens_hsa051310.99270738
54Pathways in cancer_Homo sapiens_hsa052000.98701266
55Hepatitis B_Homo sapiens_hsa051610.98690307
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98625120
57Endometrial cancer_Homo sapiens_hsa052130.96719348
58Graft-versus-host disease_Homo sapiens_hsa053320.95663926
59Dopaminergic synapse_Homo sapiens_hsa047280.95067536
60Oocyte meiosis_Homo sapiens_hsa041140.92583771
61Propanoate metabolism_Homo sapiens_hsa006400.91677157
62Wnt signaling pathway_Homo sapiens_hsa043100.91442119
63Viral carcinogenesis_Homo sapiens_hsa052030.90385069
64Thyroid cancer_Homo sapiens_hsa052160.88836858
65Glioma_Homo sapiens_hsa052140.88675733
66Epstein-Barr virus infection_Homo sapiens_hsa051690.88471596
67Herpes simplex infection_Homo sapiens_hsa051680.88367012
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88251215
69Basal transcription factors_Homo sapiens_hsa030220.87977664
70TNF signaling pathway_Homo sapiens_hsa046680.86524986
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86244765
72Rap1 signaling pathway_Homo sapiens_hsa040150.83795960
73Axon guidance_Homo sapiens_hsa043600.83544633
74Apoptosis_Homo sapiens_hsa042100.83434610
75Nicotine addiction_Homo sapiens_hsa050330.83027820
76Leishmaniasis_Homo sapiens_hsa051400.82691379
77Notch signaling pathway_Homo sapiens_hsa043300.82508886
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81467385
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80027909
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.79882774
81Non-homologous end-joining_Homo sapiens_hsa034500.79518964
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78628385
83Glutamatergic synapse_Homo sapiens_hsa047240.77225190
84Tight junction_Homo sapiens_hsa045300.76975039
85Pancreatic cancer_Homo sapiens_hsa052120.76566587
86Measles_Homo sapiens_hsa051620.76558766
87Amoebiasis_Homo sapiens_hsa051460.75853509
88Salmonella infection_Homo sapiens_hsa051320.75554296
89Phagosome_Homo sapiens_hsa041450.74266042
90Influenza A_Homo sapiens_hsa051640.73903391
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.73891872
92Allograft rejection_Homo sapiens_hsa053300.72972097
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71506440
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.71478010
95RNA polymerase_Homo sapiens_hsa030200.71232847
96GABAergic synapse_Homo sapiens_hsa047270.70651925
97Circadian entrainment_Homo sapiens_hsa047130.69927958
98HIF-1 signaling pathway_Homo sapiens_hsa040660.69008664
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68924510
100N-Glycan biosynthesis_Homo sapiens_hsa005100.67909609
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67550853
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.67344948
103FoxO signaling pathway_Homo sapiens_hsa040680.66631705
104Ras signaling pathway_Homo sapiens_hsa040140.66629800
105Bladder cancer_Homo sapiens_hsa052190.66600040
106Amphetamine addiction_Homo sapiens_hsa050310.66161967
107cAMP signaling pathway_Homo sapiens_hsa040240.65898049
108Lysine degradation_Homo sapiens_hsa003100.64593803
109Pyrimidine metabolism_Homo sapiens_hsa002400.64531592
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64437969
111Thyroid hormone synthesis_Homo sapiens_hsa049180.63470227
112Cholinergic synapse_Homo sapiens_hsa047250.61851659
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61540443
114Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61365181
115Protein digestion and absorption_Homo sapiens_hsa049740.61039234
116Antigen processing and presentation_Homo sapiens_hsa046120.58870239
117Toxoplasmosis_Homo sapiens_hsa051450.58354781
118Type I diabetes mellitus_Homo sapiens_hsa049400.57124347
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56613464
120Platelet activation_Homo sapiens_hsa046110.56011595
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55770704
122Selenocompound metabolism_Homo sapiens_hsa004500.54569117
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54203442
124Estrogen signaling pathway_Homo sapiens_hsa049150.53047846
125Long-term depression_Homo sapiens_hsa047300.52969802
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52787660
127Protein export_Homo sapiens_hsa030600.51980729
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.51545852
129Autoimmune thyroid disease_Homo sapiens_hsa053200.50838038
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.50402373
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49907094
132Asthma_Homo sapiens_hsa053100.49295072
133Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49163178
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49117684
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47491082
136Renal cell carcinoma_Homo sapiens_hsa052110.46991478
137Dorso-ventral axis formation_Homo sapiens_hsa043200.45073612
138Pyruvate metabolism_Homo sapiens_hsa006200.44027730
139Vitamin B6 metabolism_Homo sapiens_hsa007500.43316213
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41070178
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40699927
142Morphine addiction_Homo sapiens_hsa050320.37835651
143Serotonergic synapse_Homo sapiens_hsa047260.36946358
144Calcium signaling pathway_Homo sapiens_hsa040200.36753758
145Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36579513
146AMPK signaling pathway_Homo sapiens_hsa041520.36322698
147Oxytocin signaling pathway_Homo sapiens_hsa049210.35190318
148Vibrio cholerae infection_Homo sapiens_hsa051100.35134294
149Fatty acid metabolism_Homo sapiens_hsa012120.34982872
150Fatty acid elongation_Homo sapiens_hsa000620.34564384

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