SEPT12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.92546322
2epithelial cilium movement (GO:0003351)9.72449673
3plasma membrane fusion (GO:0045026)9.65655409
4spermatid development (GO:0007286)9.36211179
5motile cilium assembly (GO:0044458)9.28785467
6piRNA metabolic process (GO:0034587)9.26855821
7reproduction (GO:0000003)8.95225811
8cilium movement (GO:0003341)8.23383332
9male meiosis (GO:0007140)8.17236195
10regulation of cilium movement (GO:0003352)8.12345113
11synaptonemal complex organization (GO:0070193)7.98799011
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.88651554
13synaptonemal complex assembly (GO:0007130)7.84323900
14single fertilization (GO:0007338)7.11195209
15sperm capacitation (GO:0048240)6.93828112
16negative regulation of inclusion body assembly (GO:0090084)6.70528672
17spermatogenesis (GO:0007283)6.19548674
18male gamete generation (GO:0048232)6.17632956
19fertilization (GO:0009566)6.13354394
20microtubule depolymerization (GO:0007019)6.10320796
21behavioral response to nicotine (GO:0035095)5.83295639
22DNA methylation involved in gamete generation (GO:0043046)5.78269663
23male meiosis I (GO:0007141)5.73008610
24gamete generation (GO:0007276)5.68279626
25organic cation transport (GO:0015695)5.57935544
26regulation of inclusion body assembly (GO:0090083)5.56019701
27chromosome organization involved in meiosis (GO:0070192)5.42388328
28germ cell development (GO:0007281)5.30701081
29cellular process involved in reproduction in multicellular organism (GO:0022412)5.20521582
30ventricular system development (GO:0021591)5.10427482
31meiotic nuclear division (GO:0007126)5.00516640
32negative regulation of mast cell activation (GO:0033004)4.98283002
33calcium ion-dependent exocytosis (GO:0017156)4.87315357
34regulation of microtubule-based movement (GO:0060632)4.81253944
35meiosis I (GO:0007127)4.79465413
36seminiferous tubule development (GO:0072520)4.74106653
37cell recognition (GO:0008037)4.71739448
38spermatid nucleus differentiation (GO:0007289)4.67112792
39microtubule severing (GO:0051013)4.66590880
40indole-containing compound catabolic process (GO:0042436)4.56485980
41indolalkylamine catabolic process (GO:0046218)4.56485980
42tryptophan catabolic process (GO:0006569)4.56485980
43multicellular organismal reproductive process (GO:0048609)4.44998653
44meiotic cell cycle (GO:0051321)4.33821835
45chromosome condensation (GO:0030261)4.31873083
46DNA packaging (GO:0006323)4.13353625
47chaperone-mediated protein complex assembly (GO:0051131)4.11758014
48left/right pattern formation (GO:0060972)4.05569359
49tryptophan metabolic process (GO:0006568)3.96149372
50glycerol ether metabolic process (GO:0006662)3.87328985
51indolalkylamine metabolic process (GO:0006586)3.86679509
52monoubiquitinated protein deubiquitination (GO:0035520)3.81487917
53kynurenine metabolic process (GO:0070189)3.76142504
54single strand break repair (GO:0000012)3.68642927
55protein localization to cilium (GO:0061512)3.64577915
56axon ensheathment in central nervous system (GO:0032291)3.60891923
57central nervous system myelination (GO:0022010)3.60891923
58protein polyglutamylation (GO:0018095)3.58493965
59genitalia morphogenesis (GO:0035112)3.58277923
60ether metabolic process (GO:0018904)3.57386747
61multicellular organismal development (GO:0007275)3.54906860
62gene silencing by RNA (GO:0031047)3.46103118
63detection of light stimulus involved in sensory perception (GO:0050962)3.42754651
64detection of light stimulus involved in visual perception (GO:0050908)3.42754651
65regulation of spindle checkpoint (GO:0090231)3.39707240
66meiotic cell cycle process (GO:1903046)3.38508252
67RNA destabilization (GO:0050779)3.32170761
68macroautophagy (GO:0016236)3.26563821
69alditol metabolic process (GO:0019400)3.26155278
70amine catabolic process (GO:0009310)3.24162751
71cellular biogenic amine catabolic process (GO:0042402)3.24162751
72sexual reproduction (GO:0019953)3.23746294
73response to pheromone (GO:0019236)3.21889341
74positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.21574419
75microtubule polymerization or depolymerization (GO:0031109)3.20424241
76protein refolding (GO:0042026)3.19881180
77nucleoside diphosphate phosphorylation (GO:0006165)3.19300222
78establishment of mitochondrion localization (GO:0051654)3.18942474
79indole-containing compound metabolic process (GO:0042430)3.18702813
80behavioral response to ethanol (GO:0048149)3.14750442
81valine metabolic process (GO:0006573)3.14047097
82positive regulation of gastrulation (GO:2000543)3.13874770
83signal peptide processing (GO:0006465)3.13544680
84L-fucose catabolic process (GO:0042355)3.12527636
85fucose catabolic process (GO:0019317)3.12527636
86L-fucose metabolic process (GO:0042354)3.12527636
87synapsis (GO:0007129)3.10057474
88intraciliary transport (GO:0042073)3.09554495
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.09445289
90ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.09267622
91amino-acid betaine transport (GO:0015838)3.06284890
92carnitine transport (GO:0015879)3.06284890
93microtubule-based movement (GO:0007018)3.05989709
94axoneme assembly (GO:0035082)3.04580995
95protein K11-linked deubiquitination (GO:0035871)3.04343595
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.04043430
97neuronal action potential (GO:0019228)3.03037339
98nucleus organization (GO:0006997)3.02491111
99interferon-gamma secretion (GO:0072643)3.01543235
100sulfation (GO:0051923)3.01231902
101establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00985616
102mitochondrion transport along microtubule (GO:0047497)3.00985616
103regulation of centriole replication (GO:0046599)3.00639925
104polyol catabolic process (GO:0046174)2.98845984
105opioid receptor signaling pathway (GO:0038003)2.98785826
106adaptation of signaling pathway (GO:0023058)2.97911871
107carnitine transmembrane transport (GO:1902603)2.97327008
108tachykinin receptor signaling pathway (GO:0007217)2.96450959
109detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95786085
110mitotic sister chromatid cohesion (GO:0007064)2.95629956
111spinal cord association neuron differentiation (GO:0021527)2.94584215
112negative regulation of organelle assembly (GO:1902116)2.93962263
113neuronal action potential propagation (GO:0019227)2.93496839
114NAD biosynthetic process (GO:0009435)2.92012469
115positive regulation of growth hormone secretion (GO:0060124)2.91751833
116regulation of hexokinase activity (GO:1903299)2.87341928
117regulation of glucokinase activity (GO:0033131)2.87341928
118cilium organization (GO:0044782)2.87055286
119GTP biosynthetic process (GO:0006183)2.85659532
120substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.84991894
121substrate-independent telencephalic tangential migration (GO:0021826)2.84991894
122regulation of meiosis I (GO:0060631)2.83336143
123activated T cell proliferation (GO:0050798)2.82256552
124regulation of action potential (GO:0098900)2.81571339
125presynaptic membrane organization (GO:0097090)2.81388217
126centriole assembly (GO:0098534)2.78736385
127centriole replication (GO:0007099)2.77483714
128DNA deamination (GO:0045006)2.77127066
129regulation of synapse structural plasticity (GO:0051823)2.75805933
130cilium assembly (GO:0042384)2.74391439
131cerebellar Purkinje cell differentiation (GO:0021702)2.73033454
132gene silencing (GO:0016458)2.71937018
133glycerol metabolic process (GO:0006071)2.71147845
134primary amino compound metabolic process (GO:1901160)2.70852201
135somite rostral/caudal axis specification (GO:0032525)2.69410821
136protein-cofactor linkage (GO:0018065)2.69295331
137cilium morphogenesis (GO:0060271)2.67984157
138reciprocal DNA recombination (GO:0035825)2.67290988
139reciprocal meiotic recombination (GO:0007131)2.67290988
140cellular component assembly involved in morphogenesis (GO:0010927)2.66650878
141cellular ketone body metabolic process (GO:0046950)2.64404233
142synaptic transmission, cholinergic (GO:0007271)2.62416410
143glycolytic process (GO:0006096)2.61328287
144phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.60201526
145nonmotile primary cilium assembly (GO:0035058)2.58856972
1463-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.57955668
147purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.57955668
148maturation of 5.8S rRNA (GO:0000460)2.57819310
149UTP biosynthetic process (GO:0006228)2.57345364
150prenylation (GO:0097354)2.56922360
151protein prenylation (GO:0018342)2.56922360
152nuclear pore complex assembly (GO:0051292)2.55553276
153positive regulation of sodium ion transmembrane transport (GO:1902307)2.54771139
154inositol phosphate catabolic process (GO:0071545)2.53993974
155histone exchange (GO:0043486)2.53426763
156neurofilament cytoskeleton organization (GO:0060052)2.51817408
157cell differentiation in spinal cord (GO:0021515)2.51680753
158serotonin metabolic process (GO:0042428)2.51011795
159parturition (GO:0007567)2.50634189
160positive regulation of action potential (GO:0045760)2.50340681
161RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.49439994
162tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.49439994
163neuronal ion channel clustering (GO:0045161)2.49228032
164nicotinamide nucleotide biosynthetic process (GO:0019359)2.48708963
165peptidyl-glutamic acid modification (GO:0018200)2.44473789
166lactate metabolic process (GO:0006089)2.42989244
167cilium or flagellum-dependent cell motility (GO:0001539)12.7425945
168fusion of sperm to egg plasma membrane (GO:0007342)12.7240828
169sperm motility (GO:0030317)12.6578407
170cell wall macromolecule catabolic process (GO:0016998)11.3391148
171cell wall macromolecule metabolic process (GO:0044036)11.3391148
172sperm-egg recognition (GO:0035036)11.0893310
173acrosome assembly (GO:0001675)10.8848343
174acrosome reaction (GO:0007340)10.7673007
175multicellular organism reproduction (GO:0032504)10.5850567
176axonemal dynein complex assembly (GO:0070286)10.2236814
177binding of sperm to zona pellucida (GO:0007339)10.1282521

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.34198435
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.30737847
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.39024264
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.28078809
5GBX2_23144817_ChIP-Seq_PC3_Human3.13334105
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99751047
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.57612343
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48858158
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.47794135
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27767897
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.27413373
12IGF1R_20145208_ChIP-Seq_DFB_Human2.23034032
13VDR_22108803_ChIP-Seq_LS180_Human2.21931317
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.18929434
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13157278
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07670220
17ZNF274_21170338_ChIP-Seq_K562_Hela2.04340492
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03738156
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.2997872
20FUS_26573619_Chip-Seq_HEK293_Human1.97547437
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95387473
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89538859
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86907226
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83414771
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.78106792
26ER_23166858_ChIP-Seq_MCF-7_Human1.72948181
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72804362
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71794779
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.71174509
30IRF1_19129219_ChIP-ChIP_H3396_Human1.68684160
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68067791
32STAT1_17558387_ChIP-Seq_HELA_Human1.65686562
33KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.65473424
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64045635
35RNF2_27304074_Chip-Seq_NSC_Mouse1.63241813
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.60716202
37TP53_22573176_ChIP-Seq_HFKS_Human1.58825274
38TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.57810866
39GATA3_21867929_ChIP-Seq_CD8_Mouse1.55910171
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54095262
41SOX2_22085726_ChIP-Seq_NPCs_Mouse1.52569982
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.52338433
43AR_21572438_ChIP-Seq_LNCaP_Human1.49285910
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48303803
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46961677
46P300_19829295_ChIP-Seq_ESCs_Human1.45548368
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.45152904
48EWS_26573619_Chip-Seq_HEK293_Human1.43922969
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.43889238
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43339332
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.43150699
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42745608
53TAF15_26573619_Chip-Seq_HEK293_Human1.42329441
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41150248
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.39668974
56ERA_21632823_ChIP-Seq_H3396_Human1.39103922
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38944392
58SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38240983
59MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.37514365
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.36414286
61FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33719928
62EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.32942725
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32335456
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.32154159
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32154159
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.31840263
67GATA3_21867929_ChIP-Seq_TH1_Mouse1.29369848
68LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28977866
69TAL1_26923725_Chip-Seq_HPCs_Mouse1.28817614
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28775802
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27746250
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27364752
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26873755
74CBP_20019798_ChIP-Seq_JUKART_Human1.26873755
75DROSHA_22980978_ChIP-Seq_HELA_Human1.26203919
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26077234
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25364363
78AR_25329375_ChIP-Seq_VCAP_Human1.25245800
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24740613
80P53_21459846_ChIP-Seq_SAOS-2_Human1.24286043
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24203635
82TAF2_19829295_ChIP-Seq_ESCs_Human1.22640936
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22616916
84KDM2B_26808549_Chip-Seq_REH_Human1.22249071
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21215814
86SMAD4_21799915_ChIP-Seq_A2780_Human1.20385288
87MYC_19829295_ChIP-Seq_ESCs_Human1.19536308
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19440284
89STAT3_23295773_ChIP-Seq_U87_Human1.19212567
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19190648
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18388025
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17688686
93SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17613344
94FOXH1_21741376_ChIP-Seq_ESCs_Human1.17483552
95RUNX2_22187159_ChIP-Seq_PCA_Human1.17153413
96YY1_22570637_ChIP-Seq_MALME-3M_Human1.16892893
97NCOR_22424771_ChIP-Seq_293T_Human1.16689236
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16639541
99REST_21632747_ChIP-Seq_MESCs_Mouse1.16344859
100CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15990614
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14862795
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.14609488
103AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13889154
104RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13776003
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13192294
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13079125
107SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11898781
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11001257
109GF1_26923725_Chip-Seq_HPCs_Mouse1.10422863
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10263736
111AR_20517297_ChIP-Seq_VCAP_Human1.09939747
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09784047
113SPI1_26923725_Chip-Seq_HPCs_Mouse1.09335826
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.08866286
115CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08525278
116CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08357320
117SMAD4_21741376_ChIP-Seq_EPCs_Human1.08034303
118TCF4_23295773_ChIP-Seq_U87_Human1.07239157
119OCT4_20526341_ChIP-Seq_ESCs_Human1.07173869
120RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06275632
121RARA_24833708_ChIP-Seq_LIVER_Mouse1.05134584
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05003229
123BCL6_27268052_Chip-Seq_Bcells_Human1.04215962
124RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04202090
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.03911128
126MYC_18940864_ChIP-ChIP_HL60_Human1.03083576
127TCF4_22108803_ChIP-Seq_LS180_Human1.02255144
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02165059
129SOX2_19829295_ChIP-Seq_ESCs_Human1.02043297
130NANOG_19829295_ChIP-Seq_ESCs_Human1.02043297
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01615130
132HOXB7_26014856_ChIP-Seq_BT474_Human1.01527992
133RAC3_21632823_ChIP-Seq_H3396_Human1.00832011
134ERG_20517297_ChIP-Seq_VCAP_Human1.00187313
135PIAS1_25552417_ChIP-Seq_VCAP_Human1.00037890
136E2F1_20622854_ChIP-Seq_HELA_Human0.99530168
137FLI1_21867929_ChIP-Seq_CD8_Mouse0.99169762
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.97271718
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.97200708
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96951759
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96333071
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96007434
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.95683749
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95671182
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95614251
146LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95518824
147BCAT_22108803_ChIP-Seq_LS180_Human0.95409472
148SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95167351
149OCT4_18555785_Chip-Seq_ESCs_Mouse0.95000872
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94357745
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94109274
152POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94109274
153PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92209388
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92146123
155CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90073469
156SOX2_21211035_ChIP-Seq_LN229_Human0.90067739
157MYC_27129775_Chip-Seq_CORNEA_Mouse0.89859481
158NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89658860
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.89155355
160PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87990020
161KLF4_18555785_Chip-Seq_ESCs_Mouse0.87103242
162SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86489072
163RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86041045
164GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85770048
165OCT4_21477851_ChIP-Seq_ESCs_Mouse0.85356517
166PHF8_20622854_ChIP-Seq_HELA_Human0.85144081
167NFYB_21822215_ChIP-Seq_K562_Human0.84531441
168NANOG_20526341_ChIP-Seq_ESCs_Human0.84472761
169EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84378758
170ESRRB_18555785_Chip-Seq_ESCs_Mouse0.83506209
171JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.83444967
172ELF1_20517297_ChIP-Seq_JURKAT_Human0.83415225
173ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83323173
174CTCF_20526341_ChIP-Seq_ESCs_Human0.82873674
175SOX11_22085726_ChIP-Seq_ESNs_Mouse0.82444666
176P300_18555785_Chip-Seq_ESCs_Mouse0.82084684
177P53_22387025_ChIP-Seq_ESCs_Mouse0.81939805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003698_abnormal_male_reproductive5.93756306
2* MP0001929_abnormal_gametogenesis5.54530102
3MP0008877_abnormal_DNA_methylation4.86975008
4MP0003787_abnormal_imprinting4.45331833
5MP0005423_abnormal_somatic_nervous4.38210349
6* MP0002210_abnormal_sex_determination3.64813558
7MP0002653_abnormal_ependyma_morphology3.37444755
8* MP0002161_abnormal_fertility/fecundity3.28468547
9MP0001986_abnormal_taste_sensitivity3.26981871
10* MP0001145_abnormal_male_reproductive3.08807010
11* MP0000653_abnormal_sex_gland2.68454949
12MP0009379_abnormal_foot_pigmentation2.49376530
13MP0005670_abnormal_white_adipose2.34521192
14MP0003121_genomic_imprinting2.29799026
15MP0006292_abnormal_olfactory_placode2.12474869
16MP0001968_abnormal_touch/_nociception2.11566248
17MP0008875_abnormal_xenobiotic_pharmacok2.08025321
18MP0006276_abnormal_autonomic_nervous2.01438539
19MP0005410_abnormal_fertilization15.4655739
20MP0002822_catalepsy1.96846835
21MP0009745_abnormal_behavioral_response1.94148728
22MP0001529_abnormal_vocalization1.93790128
23MP0003122_maternal_imprinting1.93431553
24MP0005645_abnormal_hypothalamus_physiol1.88423822
25MP0005623_abnormal_meninges_morphology1.86537699
26MP0003880_abnormal_central_pattern1.81541620
27MP0002876_abnormal_thyroid_physiology1.77847516
28MP0002160_abnormal_reproductive_system1.77821497
29MP0005646_abnormal_pituitary_gland1.74651341
30MP0002272_abnormal_nervous_system1.66634285
31MP0002638_abnormal_pupillary_reflex1.65981280
32MP0008872_abnormal_physiological_respon1.65492805
33MP0001486_abnormal_startle_reflex1.63532934
34MP0003646_muscle_fatigue1.62074085
35MP0004142_abnormal_muscle_tone1.59224573
36MP0008058_abnormal_DNA_repair1.58239410
37MP0002572_abnormal_emotion/affect_behav1.55542850
38MP0002138_abnormal_hepatobiliary_system1.51538732
39MP0002063_abnormal_learning/memory/cond1.46749376
40MP0001501_abnormal_sleep_pattern1.45680395
41MP0001188_hyperpigmentation1.43810847
42MP0001905_abnormal_dopamine_level1.43238914
43MP0002557_abnormal_social/conspecific_i1.40549341
44MP0008057_abnormal_DNA_replication1.40206991
45MP0010094_abnormal_chromosome_stability1.37834223
46MP0001970_abnormal_pain_threshold1.37575986
47MP0005084_abnormal_gallbladder_morpholo1.35089460
48MP0002064_seizures1.34060374
49MP0003635_abnormal_synaptic_transmissio1.34013895
50MP0003283_abnormal_digestive_organ1.30266029
51MP0002837_dystrophic_cardiac_calcinosis1.28557643
52MP0002736_abnormal_nociception_after1.27800971
53MP0002733_abnormal_thermal_nociception1.27716251
54MP0003111_abnormal_nucleus_morphology1.25598369
55MP0004233_abnormal_muscle_weight1.25306314
56MP0002282_abnormal_trachea_morphology1.21666679
57MP0003123_paternal_imprinting1.21187752
58MP0005174_abnormal_tail_pigmentation1.18508132
59MP0002734_abnormal_mechanical_nocicepti1.17535635
60MP0005386_behavior/neurological_phenoty1.14807906
61MP0004924_abnormal_behavior1.14807906
62MP0000955_abnormal_spinal_cord1.14510849
63MP0004885_abnormal_endolymph1.14464689
64MP0002184_abnormal_innervation1.13121588
65MP0004859_abnormal_synaptic_plasticity1.06989898
66MP0002735_abnormal_chemical_nociception1.06662877
67MP0000427_abnormal_hair_cycle1.03675840
68MP0002067_abnormal_sensory_capabilities1.03396059
69MP0009046_muscle_twitch1.00925024
70MP0003693_abnormal_embryo_hatching1.00296230
71MP0000538_abnormal_urinary_bladder0.99815039
72MP0000778_abnormal_nervous_system0.98734240
73MP0002752_abnormal_somatic_nervous0.98668146
74MP0000230_abnormal_systemic_arterial0.96619225
75MP0005389_reproductive_system_phenotype0.96607709
76MP0005647_abnormal_sex_gland0.93158893
77MP0001984_abnormal_olfaction0.92895848
78MP0002234_abnormal_pharynx_morphology0.91670763
79MP0003786_premature_aging0.91538651
80MP0001765_abnormal_ion_homeostasis0.91418240
81MP0005379_endocrine/exocrine_gland_phen0.91214890
82MP0002229_neurodegeneration0.91114310
83MP0000631_abnormal_neuroendocrine_gland0.90385059
84MP0001485_abnormal_pinna_reflex0.90236284
85MP0002882_abnormal_neuron_morphology0.90135519
86MP0006072_abnormal_retinal_apoptosis0.88342431
87MP0005195_abnormal_posterior_eye0.87105985
88MP0005377_hearing/vestibular/ear_phenot0.85953375
89MP0003878_abnormal_ear_physiology0.85953375
90MP0008995_early_reproductive_senescence0.84978125
91MP0000026_abnormal_inner_ear0.82915995
92MP0010386_abnormal_urinary_bladder0.82442646
93MP0001963_abnormal_hearing_physiology0.79073236
94MP0004043_abnormal_pH_regulation0.78754496
95MP0002163_abnormal_gland_morphology0.78654167
96MP0008007_abnormal_cellular_replicative0.78653410
97MP0000358_abnormal_cell_content/0.78383744
98MP0003119_abnormal_digestive_system0.76999879
99MP0004130_abnormal_muscle_cell0.76632827
100MP0005448_abnormal_energy_balance0.75956924
101MP0003195_calcinosis0.75879022
102MP0003011_delayed_dark_adaptation0.75565276
103MP0004742_abnormal_vestibular_system0.74384904
104MP0002095_abnormal_skin_pigmentation0.71026065
105MP0001664_abnormal_digestion0.71017320
106MP0003077_abnormal_cell_cycle0.69457629
107MP0001730_embryonic_growth_arrest0.64533648
108MP0003699_abnormal_female_reproductive0.61003678
109MP0005397_hematopoietic_system_phenotyp0.58592523
110MP0001545_abnormal_hematopoietic_system0.58592523
111MP0003950_abnormal_plasma_membrane0.57365243
112MP0003115_abnormal_respiratory_system0.57062570
113MP0003329_amyloid_beta_deposits0.56434169
114MP0004957_abnormal_blastocyst_morpholog0.55975699
115MP0002102_abnormal_ear_morphology0.55915593
116MP0005636_abnormal_mineral_homeostasis0.54911243
117MP0001764_abnormal_homeostasis0.54281612
118MP0001293_anophthalmia0.52928225
119MP0010307_abnormal_tumor_latency0.48778851
120MP0005666_abnormal_adipose_tissue0.48484638
121MP0000569_abnormal_digit_pigmentation0.48357380
122MP0002269_muscular_atrophy0.48308015
123MP0003718_maternal_effect0.47593273
124MP0001119_abnormal_female_reproductive0.47366903
125MP0009278_abnormal_bone_marrow0.46464944
126MP0006036_abnormal_mitochondrial_physio0.45696861
127MP0004019_abnormal_vitamin_homeostasis0.42328723
128MP0008932_abnormal_embryonic_tissue0.41694237
129MP0006035_abnormal_mitochondrial_morpho0.39764718
130MP0001324_abnormal_eye_pigmentation0.39218516
131MP0001661_extended_life_span0.39201749
132MP0004808_abnormal_hematopoietic_stem0.39098378
133MP0004036_abnormal_muscle_relaxation0.38259216
134MP0005380_embryogenesis_phenotype0.37075161
135MP0001672_abnormal_embryogenesis/_devel0.37075161
136MP0000313_abnormal_cell_death0.36756077
137MP0001727_abnormal_embryo_implantation0.36511956
138MP0003879_abnormal_hair_cell0.32955741
139MP0005391_vision/eye_phenotype0.32323916
140MP0001697_abnormal_embryo_size0.32050805
141MP0002084_abnormal_developmental_patter0.31422955
142MP0002080_prenatal_lethality0.30021468
143MP0002971_abnormal_brown_adipose0.29635684
144MP0009115_abnormal_fat_cell0.29029386
145MP0003984_embryonic_growth_retardation0.28769555
146MP0005551_abnormal_eye_electrophysiolog0.28435240
147MP0003861_abnormal_nervous_system0.28208996
148MP0002092_abnormal_eye_morphology0.27454981
149MP0005253_abnormal_eye_physiology0.27061980
150MP0002088_abnormal_embryonic_growth/wei0.26609818
151MP0005451_abnormal_body_composition0.26549007
152MP0002928_abnormal_bile_duct0.24043816
153MP0002132_abnormal_respiratory_system0.23857442
154MP0002085_abnormal_embryonic_tissue0.22635419
155MP0000604_amyloidosis0.22589361
156MP0002169_no_abnormal_phenotype0.22274393
157MP0002873_normal_phenotype0.21899985
158MP0003315_abnormal_perineum_morphology0.21586929
159MP0000534_abnormal_ureter_morphology0.21584233
160MP0005395_other_phenotype0.20859538
161MP0002796_impaired_skin_barrier0.20718217
162MP0002152_abnormal_brain_morphology0.20175964
163MP0003936_abnormal_reproductive_system0.18623883
164MP0000001_mammalian_phenotype0.18118745
165MP0008260_abnormal_autophagy0.17508779
166MP0004811_abnormal_neuron_physiology0.16564924
167MP0004133_heterotaxia0.16479521
168MP0001440_abnormal_grooming_behavior0.14882855
169MP0009672_abnormal_birth_weight0.14812589
170MP0004145_abnormal_muscle_electrophysio0.14715958
171MP0001919_abnormal_reproductive_system0.14534934
172MP0000647_abnormal_sebaceous_gland0.13743091

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.40294012
2Abnormal respiratory motile cilium morphology (HP:0005938)9.15498993
3Abnormal respiratory epithelium morphology (HP:0012253)9.15498993
4Rhinitis (HP:0012384)7.94101642
5Abnormal ciliary motility (HP:0012262)7.45454526
6Chronic bronchitis (HP:0004469)7.35029541
7Nasal polyposis (HP:0100582)6.47520604
8* Infertility (HP:0000789)5.92142443
9Abnormality of the nasal mucosa (HP:0000433)5.28046739
10Absent rod-and cone-mediated responses on ERG (HP:0007688)4.94059377
11Bronchiectasis (HP:0002110)4.62484088
12Attenuation of retinal blood vessels (HP:0007843)4.61109790
13Bronchitis (HP:0012387)4.60727073
14Abnormal rod and cone electroretinograms (HP:0008323)4.36978904
15Nephronophthisis (HP:0000090)4.27044441
16Pancreatic cysts (HP:0001737)4.19437195
17Male infertility (HP:0003251)4.11237998
18Chronic hepatic failure (HP:0100626)3.95323395
19Pendular nystagmus (HP:0012043)3.73829148
20Abnormal pancreas size (HP:0012094)3.53214142
21Abnormal spermatogenesis (HP:0008669)3.49523647
22Congenital stationary night blindness (HP:0007642)3.41341855
23Recurrent otitis media (HP:0000403)3.36770249
24Recurrent sinusitis (HP:0011108)3.30469467
25Abnormality of the renal medulla (HP:0100957)3.22535167
26Keratoconus (HP:0000563)3.16576786
27Increased corneal curvature (HP:0100692)3.16576786
28Impulsivity (HP:0100710)3.04785853
29Gonadotropin excess (HP:0000837)2.86693903
30Recurrent bronchitis (HP:0002837)2.77858762
31Abolished electroretinogram (ERG) (HP:0000550)2.76511282
323-Methylglutaconic aciduria (HP:0003535)2.72840677
33Tubulointerstitial nephritis (HP:0001970)2.69995448
34Abnormality of the labia minora (HP:0012880)2.61841285
35Abnormality of midbrain morphology (HP:0002418)2.61496328
36Molar tooth sign on MRI (HP:0002419)2.61496328
37Abnormality of the lower motor neuron (HP:0002366)2.52220793
38Medial flaring of the eyebrow (HP:0010747)2.51778007
39Azoospermia (HP:0000027)2.51705255
40Bony spicule pigmentary retinopathy (HP:0007737)2.47681996
41Anencephaly (HP:0002323)2.40263648
42Male pseudohermaphroditism (HP:0000037)2.39902104
43Abnormality of dental color (HP:0011073)2.39818412
44Tubular atrophy (HP:0000092)2.38792027
45Myokymia (HP:0002411)2.34124544
46Progressive cerebellar ataxia (HP:0002073)2.32140635
47Sclerocornea (HP:0000647)2.32054529
48Abnormality of alanine metabolism (HP:0010916)2.31438543
49Hyperalaninemia (HP:0003348)2.31438543
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.31438543
51Stomach cancer (HP:0012126)2.27838209
52Severe visual impairment (HP:0001141)2.26328046
53Tubulointerstitial abnormality (HP:0001969)2.25018012
54Type II lissencephaly (HP:0007260)2.22698625
55Amyotrophic lateral sclerosis (HP:0007354)2.19695133
56Agitation (HP:0000713)2.14288551
57Hypoplasia of the capital femoral epiphysis (HP:0003090)2.14241514
58Aplasia/Hypoplasia of the spleen (HP:0010451)2.07609942
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05810341
60Polyuria (HP:0000103)2.05197586
61Metaphyseal dysplasia (HP:0100255)2.03833641
62Polyphagia (HP:0002591)2.03070697
63Spastic tetraparesis (HP:0001285)2.01869729
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6094336
65Absent/shortened dynein arms (HP:0200106)12.8635431
66Dynein arm defect of respiratory motile cilia (HP:0012255)12.8635431
67Fibular hypoplasia (HP:0003038)1.99954615
68Postaxial foot polydactyly (HP:0001830)1.98842321
69Asplenia (HP:0001746)1.98117411
70Hypoplasia of the uterus (HP:0000013)1.96742664
71Epileptic encephalopathy (HP:0200134)1.94783549
72Lissencephaly (HP:0001339)1.93794030
73Patellar aplasia (HP:0006443)1.89784587
74Occipital encephalocele (HP:0002085)1.87764955
75Oligodactyly (hands) (HP:0001180)1.86692525
76Hyperglycinemia (HP:0002154)1.86487411
77Optic disc pallor (HP:0000543)1.86118384
78Broad-based gait (HP:0002136)1.85902005
79Testicular atrophy (HP:0000029)1.83534168
80Aplasia/Hypoplasia of the patella (HP:0006498)1.81373793
81Pachygyria (HP:0001302)1.80116534
82Congenital sensorineural hearing impairment (HP:0008527)1.79833995
83Progressive inability to walk (HP:0002505)1.79235936
84Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78875857
85Inability to walk (HP:0002540)1.77776195
86Congenital hepatic fibrosis (HP:0002612)1.77644905
87Furrowed tongue (HP:0000221)1.77052123
88Cerebral hypomyelination (HP:0006808)1.77048369
89Stage 5 chronic kidney disease (HP:0003774)1.76639127
90Tubulointerstitial fibrosis (HP:0005576)1.76575426
91Drooling (HP:0002307)1.75453331
92Abnormal urine output (HP:0012590)1.75172008
93Gaze-evoked nystagmus (HP:0000640)1.74625992
94Abnormal gallbladder physiology (HP:0012438)1.74625704
95Cholecystitis (HP:0001082)1.74625704
96Hyperventilation (HP:0002883)1.74615210
97CNS hypomyelination (HP:0003429)1.73072242
98Type 2 muscle fiber atrophy (HP:0003554)1.72462086
99Oculomotor apraxia (HP:0000657)1.72256663
100Short ribs (HP:0000773)1.71545485
101Dyskinesia (HP:0100660)1.70442130
102Facial cleft (HP:0002006)1.70415444
103Absent epiphyses (HP:0010577)1.67733516
104Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67733516
105Hyperglycinuria (HP:0003108)1.67447973
106Mesangial abnormality (HP:0001966)1.67260648
107Microglossia (HP:0000171)1.67180016
108Abnormality of the dental root (HP:0006486)1.65840175
109Taurodontia (HP:0000679)1.65840175
110Abnormality of permanent molar morphology (HP:0011071)1.65840175
111Focal seizures (HP:0007359)1.65806309
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.65450440
113Retinitis pigmentosa (HP:0000510)1.64405511
114Supernumerary spleens (HP:0009799)1.64331575
115Chronic sinusitis (HP:0011109)1.63873707
116Photophobia (HP:0000613)1.63778653
117Type II diabetes mellitus (HP:0005978)1.63714313
118Renal dysplasia (HP:0000110)1.63225546
119Abnormality of the renal cortex (HP:0011035)1.63150160
120Aplasia/hypoplasia of the uterus (HP:0008684)1.63137365
121Disproportionate short-trunk short stature (HP:0003521)1.61364962
122Neonatal respiratory distress (HP:0002643)1.61209022
123Impaired proprioception (HP:0010831)1.61184164
124Genital tract atresia (HP:0001827)1.60711174
125Excessive salivation (HP:0003781)1.60452049
126Heterotopia (HP:0002282)1.60288894
127Abnormality of urine glucose concentration (HP:0011016)1.60233963
128Glycosuria (HP:0003076)1.60233963
129Pancreatic fibrosis (HP:0100732)1.59802842
130Degeneration of anterior horn cells (HP:0002398)1.59150743
131Abnormality of the anterior horn cell (HP:0006802)1.59150743
132Polydipsia (HP:0001959)1.55000750
133Abnormal drinking behavior (HP:0030082)1.55000750
134Bundle branch block (HP:0011710)1.53714629
135Abnormality of molar (HP:0011077)1.52917051
136Abnormality of molar morphology (HP:0011070)1.52917051
137Abnormal biliary tract physiology (HP:0012439)1.50910443
138Bile duct proliferation (HP:0001408)1.50910443
139Postaxial hand polydactyly (HP:0001162)1.50637578
140Abnormality of the dental pulp (HP:0006479)1.50396786
141Abnormality of renal excretion (HP:0011036)1.45534485
142Congenital primary aphakia (HP:0007707)1.44670523
143Abnormality of dentin (HP:0010299)1.44440606
144Bell-shaped thorax (HP:0001591)1.44096287
145Gait imbalance (HP:0002141)1.43554120
146J-shaped sella turcica (HP:0002680)1.43492424
147Dyschromatopsia (HP:0007641)1.42820803
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.41890979
149Upper motor neuron abnormality (HP:0002127)1.40148488
150Cystic liver disease (HP:0006706)1.39842276
151Median cleft lip (HP:0000161)1.37149990
152Congenital malformation of the right heart (HP:0011723)1.37016368
153Double outlet right ventricle (HP:0001719)1.37016368
154Absent frontal sinuses (HP:0002688)1.35244912
155Decreased central vision (HP:0007663)1.33987125
156Broad distal phalanx of finger (HP:0009836)1.32507493
157Aplasia/Hypoplasia of the lens (HP:0008063)1.30955034
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.30528613
159Deformed sella turcica (HP:0002681)1.28867015
160Short nail (HP:0001799)1.28592403
161Choroideremia (HP:0001139)1.26915492
162Abnormality of ocular smooth pursuit (HP:0000617)1.26285726
163Personality changes (HP:0000751)1.25493250
164Short thorax (HP:0010306)1.24493736
165Nephrogenic diabetes insipidus (HP:0009806)1.23026522
166Breast carcinoma (HP:0003002)1.22617192
167Nephropathy (HP:0000112)1.22485800
168Cerebellar dysplasia (HP:0007033)1.22330015
169Easy fatigability (HP:0003388)1.21917496
170True hermaphroditism (HP:0010459)1.20696464
171Poor coordination (HP:0002370)1.19565176
172Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.17556651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.66475072
2PDK48.66475072
3PDK25.64686869
4TESK15.09631877
5FRK4.32920434
6ZAK4.12488599
7PRKD33.92761741
8ICK3.54809716
9ADRBK22.62309976
10PNCK2.58454950
11INSRR2.41813563
12MAP3K42.25133085
13WNK42.23861324
14GRK12.21438876
15STK392.16639239
16MAPK132.09325923
17NEK22.06631035
18PTK2B2.03022824
19TAOK31.89629351
20BCKDK1.88400491
21MAP2K71.87072367
22NTRK31.85890698
23CDK81.66600972
24DYRK21.65422441
25TXK1.58563470
26STK381.57802607
27TLK11.48291165
28SIK21.47756222
29CAMKK21.45822400
30TGFBR11.41727078
31ACVR1B1.36167623
32WEE11.29614541
33DAPK21.28455178
34ADRBK11.23917243
35DYRK1B1.21602322
36PHKG21.21512204
37PHKG11.21512204
38CDK191.21355351
39LIMK11.18557197
40KIT1.15903640
41TNK21.13039958
42CCNB11.10786213
43OXSR11.09337862
44MAP2K41.07440259
45PLK41.06498644
46FLT31.06431592
47TTK1.05815685
48DYRK31.04959244
49CASK1.04406047
50MAP3K110.99935133
51PDK10.95915955
52PIK3CA0.91831956
53STK30.91804964
54MAP4K20.89391308
55MAPK150.89300120
56NUAK10.88628133
57BUB10.87689549
58TYRO30.87640196
59WNK10.84570003
60VRK10.81609781
61TNIK0.79748476
62IRAK10.78336636
63PASK0.75909792
64PLK20.74992439
65CHEK20.74500505
66TIE10.73827329
67BRSK20.72978261
68CSNK1G20.72484955
69TESK20.70823313
70MAP3K60.69713170
71CSNK1G30.69089045
72PINK10.68301646
73PRKCE0.67018378
74MAP4K10.66493229
75CDC70.64990261
76CAMK10.64309765
77STK38L0.63817703
78RPS6KA50.63595119
79CSNK1G10.58661425
80MAPKAPK30.57489851
81CHEK10.57222407
82PRKACA0.56319747
83SGK2230.55337164
84SGK4940.55337164
85PRKCH0.53415382
86PLK10.51762543
87BMPR20.51461227
88FGFR20.50795290
89ABL20.49684127
90DYRK1A0.49595497
91TRIM280.48943402
92PDPK10.48700455
93ATR0.47948171
94PAK10.44768708
95RPS6KA60.44117775
96LMTK20.41786511
97CAMK2A0.41706438
98PRKCA0.41474381
99BRSK10.41101563
100GRK60.37800363
101IRAK20.37197286
102BRAF0.36870525
103IKBKB0.36412159
104PRKD20.36146798
105SYK0.35885703
106ATM0.35582429
107EEF2K0.34912302
108MINK10.34030747
109CSNK1A1L0.33644052
110RIPK40.33043637
111PRKCG0.32184389
112OBSCN0.32181324
113NME20.32159243
114MUSK0.31188810
115MAP2K20.30898897
116MAP2K60.30786316
117SGK20.30343740
118MTOR0.28696319
119NTRK20.27751511
120CDK50.27650056
121BMPR1B0.26724381
122CAMK1G0.26598554
123EPHA20.24104939
124PRKAA10.22289467
125AKT30.21081498
126CAMKK10.20311420
127EIF2AK10.19025075
128SRPK10.18343294
129PAK20.17852423
130AURKA0.17649318
131PAK40.17367347
132CSNK2A10.15303969
133STK160.15238492
134MAPKAPK50.13713962
135AURKB0.12226359
136CDK20.12099215
137MARK30.11969031
138CDK10.11274659
139NEK60.11134151
140RPS6KB10.11055643
141CDK40.10353265
142CSNK2A20.09181390
143PRKCZ0.09061903
144WNK30.08582793
145CDK120.08559038
146CDK150.08378472
147PLK30.08307811
148MARK20.08175075
149CDK11A0.06063946
150GSK3B0.05807576
151CDK180.05522130
152CDK30.05401791
153STK100.05245176
154ZAP700.03841058
155RPS6KA10.03778953
156STK110.03707284
157PIM10.03254611
158TAOK10.02852016
159MAPK80.02459096
160CDK140.02381043
161PRKACB0.01345430
162CSNK1D0.00965176
163MARK10.00846675
164PRKDC0.00584860
165PRKCQ0.00545880
166CSNK1E0.00506566
167MAPK10-0.0321874
168PRKCB-0.0315581
169PRKG1-0.0244082
170MAP3K5-0.0133841
171PRKACG-0.0057207

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.30806772
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.91802287
3Fatty acid biosynthesis_Homo sapiens_hsa000613.44979723
4Pyruvate metabolism_Homo sapiens_hsa006203.38408710
5Basal transcription factors_Homo sapiens_hsa030223.17102238
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86059991
7Linoleic acid metabolism_Homo sapiens_hsa005912.82272237
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.81110284
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.68306636
10Propanoate metabolism_Homo sapiens_hsa006402.51275389
11Phototransduction_Homo sapiens_hsa047442.46646881
12Pentose phosphate pathway_Homo sapiens_hsa000302.44837870
13Nicotine addiction_Homo sapiens_hsa050332.36761362
14Glucagon signaling pathway_Homo sapiens_hsa049222.36434532
15Selenocompound metabolism_Homo sapiens_hsa004502.28657065
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.27061110
17Fanconi anemia pathway_Homo sapiens_hsa034602.25721348
18Butanoate metabolism_Homo sapiens_hsa006502.24267772
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.16713123
20Oocyte meiosis_Homo sapiens_hsa041142.13647171
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12875139
22Olfactory transduction_Homo sapiens_hsa047402.03185763
23Oxidative phosphorylation_Homo sapiens_hsa001902.02110117
24Dorso-ventral axis formation_Homo sapiens_hsa043202.00571756
25Tryptophan metabolism_Homo sapiens_hsa003802.00310327
26RNA transport_Homo sapiens_hsa030131.99222060
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.94177038
28Glycerolipid metabolism_Homo sapiens_hsa005611.93731914
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.91768384
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81920813
31Fructose and mannose metabolism_Homo sapiens_hsa000511.81590277
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79817881
33Huntingtons disease_Homo sapiens_hsa050161.77169826
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.68179339
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.67323719
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59996524
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59686338
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.53746082
39Nitrogen metabolism_Homo sapiens_hsa009101.52894282
40Sulfur relay system_Homo sapiens_hsa041221.52408333
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48562106
42Regulation of autophagy_Homo sapiens_hsa041401.47911337
43Purine metabolism_Homo sapiens_hsa002301.47359160
44PPAR signaling pathway_Homo sapiens_hsa033201.46918469
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46462921
46Caffeine metabolism_Homo sapiens_hsa002321.46004202
47mRNA surveillance pathway_Homo sapiens_hsa030151.44007498
48Taste transduction_Homo sapiens_hsa047421.43151167
49Carbon metabolism_Homo sapiens_hsa012001.43075183
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.41211276
51Proteasome_Homo sapiens_hsa030501.38775165
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37228882
53Parkinsons disease_Homo sapiens_hsa050121.36056281
54Ribosome_Homo sapiens_hsa030101.35956089
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32205377
56Ether lipid metabolism_Homo sapiens_hsa005651.31295662
57Fat digestion and absorption_Homo sapiens_hsa049751.28641765
58Amphetamine addiction_Homo sapiens_hsa050311.20533745
59Mineral absorption_Homo sapiens_hsa049781.18927546
60Glycosaminoglycan degradation_Homo sapiens_hsa005311.18555566
61Antigen processing and presentation_Homo sapiens_hsa046121.16713317
62Primary bile acid biosynthesis_Homo sapiens_hsa001201.16572718
63Type I diabetes mellitus_Homo sapiens_hsa049401.16063970
64Cardiac muscle contraction_Homo sapiens_hsa042601.14292967
65Morphine addiction_Homo sapiens_hsa050321.11952912
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11791034
67Pyrimidine metabolism_Homo sapiens_hsa002401.11790608
68Serotonergic synapse_Homo sapiens_hsa047261.10489235
69Intestinal immune network for IgA production_Homo sapiens_hsa046721.07776349
70One carbon pool by folate_Homo sapiens_hsa006701.07334430
71Steroid hormone biosynthesis_Homo sapiens_hsa001401.05625219
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03827204
73Glutamatergic synapse_Homo sapiens_hsa047241.02400065
74Glutathione metabolism_Homo sapiens_hsa004801.02159180
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00871530
76Biosynthesis of amino acids_Homo sapiens_hsa012301.00789033
77Fatty acid metabolism_Homo sapiens_hsa012121.00450379
78Cocaine addiction_Homo sapiens_hsa050300.98273772
79Circadian entrainment_Homo sapiens_hsa047130.94671651
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94122126
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93599493
82Asthma_Homo sapiens_hsa053100.92158648
83Dopaminergic synapse_Homo sapiens_hsa047280.91925787
84Alzheimers disease_Homo sapiens_hsa050100.88077316
85Fatty acid degradation_Homo sapiens_hsa000710.87710570
86Peroxisome_Homo sapiens_hsa041460.87363076
87GABAergic synapse_Homo sapiens_hsa047270.87162750
88Steroid biosynthesis_Homo sapiens_hsa001000.85914867
89Ovarian steroidogenesis_Homo sapiens_hsa049130.83450819
90Arachidonic acid metabolism_Homo sapiens_hsa005900.83235462
91Long-term depression_Homo sapiens_hsa047300.82679061
92RNA polymerase_Homo sapiens_hsa030200.81094100
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80866013
94Graft-versus-host disease_Homo sapiens_hsa053320.79730334
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79366236
96Hedgehog signaling pathway_Homo sapiens_hsa043400.79201588
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78984040
98Salivary secretion_Homo sapiens_hsa049700.78451652
99Protein export_Homo sapiens_hsa030600.77888745
100Renin secretion_Homo sapiens_hsa049240.75016049
101Cell cycle_Homo sapiens_hsa041100.74806334
102Collecting duct acid secretion_Homo sapiens_hsa049660.70377667
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70353736
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70052877
105Homologous recombination_Homo sapiens_hsa034400.69522952
106Gastric acid secretion_Homo sapiens_hsa049710.66277076
107Histidine metabolism_Homo sapiens_hsa003400.64890335
108Renin-angiotensin system_Homo sapiens_hsa046140.63375242
109Spliceosome_Homo sapiens_hsa030400.61580647
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59011879
111Cholinergic synapse_Homo sapiens_hsa047250.58317947
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57828608
113Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56558693
114Chemical carcinogenesis_Homo sapiens_hsa052040.55442880
115RNA degradation_Homo sapiens_hsa030180.54718120
116Oxytocin signaling pathway_Homo sapiens_hsa049210.53262179
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.53260352
118DNA replication_Homo sapiens_hsa030300.53104274
119Allograft rejection_Homo sapiens_hsa053300.52950029
120Metabolic pathways_Homo sapiens_hsa011000.52947696
121ABC transporters_Homo sapiens_hsa020100.52937356
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52441188
123Legionellosis_Homo sapiens_hsa051340.50397881
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50197782
125cAMP signaling pathway_Homo sapiens_hsa040240.48981299
126Systemic lupus erythematosus_Homo sapiens_hsa053220.48733556
127Estrogen signaling pathway_Homo sapiens_hsa049150.48381498
128Long-term potentiation_Homo sapiens_hsa047200.45148765
129AMPK signaling pathway_Homo sapiens_hsa041520.43294258
130Autoimmune thyroid disease_Homo sapiens_hsa053200.43200434
131Inositol phosphate metabolism_Homo sapiens_hsa005620.43075615
132Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42906974
133Endocytosis_Homo sapiens_hsa041440.42563299
134Epstein-Barr virus infection_Homo sapiens_hsa051690.42023101
135Axon guidance_Homo sapiens_hsa043600.40173420
136N-Glycan biosynthesis_Homo sapiens_hsa005100.39866858
137Base excision repair_Homo sapiens_hsa034100.39273071
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.39102620
139beta-Alanine metabolism_Homo sapiens_hsa004100.37564844
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35352015
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33089948
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32382115
143Calcium signaling pathway_Homo sapiens_hsa040200.31739133
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31523227
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31248581
146Type II diabetes mellitus_Homo sapiens_hsa049300.29885697
147Sphingolipid metabolism_Homo sapiens_hsa006000.28794519
148Nucleotide excision repair_Homo sapiens_hsa034200.28517034
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28260649
150Insulin secretion_Homo sapiens_hsa049110.26417200
151Thyroid hormone synthesis_Homo sapiens_hsa049180.25975312
152Vitamin digestion and absorption_Homo sapiens_hsa049770.25424926
153Bile secretion_Homo sapiens_hsa049760.23516812
154Pancreatic secretion_Homo sapiens_hsa049720.23130676
155VEGF signaling pathway_Homo sapiens_hsa043700.21281470
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21096902
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21080395
158Protein digestion and absorption_Homo sapiens_hsa049740.21055351
159Synaptic vesicle cycle_Homo sapiens_hsa047210.20962182
160Viral carcinogenesis_Homo sapiens_hsa052030.16169066
161Vascular smooth muscle contraction_Homo sapiens_hsa042700.15146631
162Retinol metabolism_Homo sapiens_hsa008300.14925564
163p53 signaling pathway_Homo sapiens_hsa041150.11957618

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