SEPT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)7.40403764
2glutamate secretion (GO:0014047)6.80494851
3fatty acid elongation (GO:0030497)6.62788661
4ensheathment of neurons (GO:0007272)6.51431292
5axon ensheathment (GO:0008366)6.51431292
6myelination (GO:0042552)6.48364565
7cellular potassium ion homeostasis (GO:0030007)6.01837331
8regulation of synaptic vesicle exocytosis (GO:2000300)6.00632064
9regulation of short-term neuronal synaptic plasticity (GO:0048172)5.92277741
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.84235608
11sodium ion export (GO:0071436)5.54980190
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.51261893
13long-chain fatty acid biosynthetic process (GO:0042759)5.47436767
14myelin maintenance (GO:0043217)5.36435962
15neurotransmitter secretion (GO:0007269)5.17316534
16regulation of synaptic vesicle transport (GO:1902803)5.13840622
17locomotory exploration behavior (GO:0035641)4.95177770
18regulation of neuronal synaptic plasticity (GO:0048168)4.78807494
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.68286086
20oligodendrocyte differentiation (GO:0048709)4.61551883
21positive regulation of synapse maturation (GO:0090129)4.60104930
22vocalization behavior (GO:0071625)4.54480041
23negative regulation of neurotransmitter secretion (GO:0046929)4.51463767
24negative regulation of neurotransmitter transport (GO:0051589)4.42654881
25ionotropic glutamate receptor signaling pathway (GO:0035235)4.40622049
26negative regulation of protein localization to cell surface (GO:2000009)4.38568106
27establishment of mitochondrion localization (GO:0051654)4.37609122
28creatine metabolic process (GO:0006600)4.30833317
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.30656412
30potassium ion homeostasis (GO:0055075)4.30625307
31regulation of long-term neuronal synaptic plasticity (GO:0048169)4.26884090
32potassium ion import (GO:0010107)4.26260794
33neurotransmitter transport (GO:0006836)4.22692157
34regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.22281577
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.14672948
36L-amino acid import (GO:0043092)4.14111472
37postsynaptic membrane organization (GO:0001941)4.13711247
38presynaptic membrane organization (GO:0097090)4.12474358
39exploration behavior (GO:0035640)4.08252672
40apical protein localization (GO:0045176)4.07824425
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.02386543
42regulation of collateral sprouting (GO:0048670)3.98468474
43neurotransmitter-gated ion channel clustering (GO:0072578)3.94671016
44synaptic transmission, glutamatergic (GO:0035249)3.91616236
45glycerophospholipid catabolic process (GO:0046475)3.90947517
46regulation of neurotransmitter levels (GO:0001505)3.89340258
47asymmetric protein localization (GO:0008105)3.85826065
48positive regulation of dendritic spine development (GO:0060999)3.85822100
49regulation of glutamate receptor signaling pathway (GO:1900449)3.84721449
50cerebellar Purkinje cell differentiation (GO:0021702)3.83873240
51positive regulation of membrane potential (GO:0045838)3.80058632
52regulation of neurotransmitter secretion (GO:0046928)3.77268484
53peptidyl-tyrosine autophosphorylation (GO:0038083)3.77013660
54photoreceptor cell differentiation (GO:0046530)3.76317888
55eye photoreceptor cell differentiation (GO:0001754)3.76317888
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73719256
57regulation of synaptic plasticity (GO:0048167)3.72640929
58astrocyte development (GO:0014002)3.72025972
59regulation of synapse maturation (GO:0090128)3.70645713
60response to methylmercury (GO:0051597)3.69862838
61adult walking behavior (GO:0007628)3.68966049
62cellular sodium ion homeostasis (GO:0006883)3.67828880
63neuromuscular process controlling balance (GO:0050885)3.67565178
64cell communication by electrical coupling (GO:0010644)3.67120121
65protein localization to synapse (GO:0035418)3.66777196
66substantia nigra development (GO:0021762)3.62797335
67presynaptic membrane assembly (GO:0097105)3.61734179
68neuron-neuron synaptic transmission (GO:0007270)3.60861018
69cholesterol biosynthetic process (GO:0006695)3.60371667
70regulation of synapse structural plasticity (GO:0051823)3.60274817
71positive regulation of oligodendrocyte differentiation (GO:0048714)3.58928358
72glutamate receptor signaling pathway (GO:0007215)3.58090411
73regulation of ARF protein signal transduction (GO:0032012)3.57351836
74import into cell (GO:0098657)3.57220329
75acidic amino acid transport (GO:0015800)3.56981970
76synaptic vesicle endocytosis (GO:0048488)3.52220503
77regulation of neurotransmitter transport (GO:0051588)3.48684206
78response to redox state (GO:0051775)3.48064609
79dendritic spine morphogenesis (GO:0060997)3.46983816
80membrane tubulation (GO:0097320)3.42964273
81regulation of postsynaptic membrane potential (GO:0060078)3.41758873
82long-term synaptic potentiation (GO:0060291)3.35571771
83long-term memory (GO:0007616)3.33586257
84neuronal action potential propagation (GO:0019227)3.33551691
85auditory behavior (GO:0031223)3.32962236
86long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.29780639
87regulation of vesicle fusion (GO:0031338)3.27371889
88myelination in peripheral nervous system (GO:0022011)3.26374596
89peripheral nervous system axon ensheathment (GO:0032292)3.26374596
90membrane depolarization during action potential (GO:0086010)3.26180000
91regulation of dendritic spine development (GO:0060998)3.25498625
92positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25253012
93regulation of dendritic spine morphogenesis (GO:0061001)3.22677704
94L-glutamate transport (GO:0015813)3.19172814
95positive regulation of neurotransmitter secretion (GO:0001956)3.18965405
96negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.18505187
97sterol biosynthetic process (GO:0016126)3.16061514
98neuron cell-cell adhesion (GO:0007158)3.15778973
99membrane depolarization (GO:0051899)3.13834110
100positive regulation of neurotransmitter transport (GO:0051590)3.13256295
101proline transport (GO:0015824)3.12611253
102glycine transport (GO:0015816)3.12228581
103long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.12105887
104adhesion of symbiont to host cell (GO:0044650)3.11983639
105virion attachment to host cell (GO:0019062)3.11983639
106regulation of synaptic transmission (GO:0050804)3.11392111
107transmission of nerve impulse (GO:0019226)3.10604115
108cell differentiation in hindbrain (GO:0021533)3.09699062
109negative regulation of dendrite morphogenesis (GO:0050774)3.09407459
110amino acid import (GO:0043090)3.08742271
111cytoskeletal anchoring at plasma membrane (GO:0007016)3.07745936
112protein palmitoylation (GO:0018345)3.07723737
113neuromuscular process controlling posture (GO:0050884)3.05655929
114layer formation in cerebral cortex (GO:0021819)3.04394363
115amyloid precursor protein metabolic process (GO:0042982)3.02765967
116cerebellar granule cell differentiation (GO:0021707)3.01480530
117positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00566354
118negative regulation of axonogenesis (GO:0050771)3.00289001
119neurotransmitter uptake (GO:0001504)2.99717338
120regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.98467694
121response to lipoprotein particle (GO:0055094)2.96491777
122positive regulation of dendrite development (GO:1900006)2.95043300
123negative regulation of JUN kinase activity (GO:0043508)2.94005847
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.93996002
125neuron remodeling (GO:0016322)2.92801040
126synaptic vesicle maturation (GO:0016188)2.88773786
127regulation of lipoprotein metabolic process (GO:0050746)2.86024562
128fatty-acyl-CoA biosynthetic process (GO:0046949)2.84326709
129isoprenoid biosynthetic process (GO:0008299)2.84042328
130neuronal ion channel clustering (GO:0045161)2.79246407
131axon development (GO:0061564)2.78378261
132fatty-acyl-CoA metabolic process (GO:0035337)2.74692089
133cerebral cortex radially oriented cell migration (GO:0021799)2.74460882
134GPI anchor biosynthetic process (GO:0006506)2.72357447
135limb bud formation (GO:0060174)2.70962969
136cyclic nucleotide catabolic process (GO:0009214)2.69217007
137peptidyl-cysteine modification (GO:0018198)2.68578133
138GPI anchor metabolic process (GO:0006505)2.67771398
139glycosylceramide metabolic process (GO:0006677)2.67619910
140negative regulation of inclusion body assembly (GO:0090084)2.67332090
141very long-chain fatty acid metabolic process (GO:0000038)2.66577019
142nerve growth factor signaling pathway (GO:0038180)2.65126382
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64900706
144magnesium ion transport (GO:0015693)2.62980989
145cellular response to epinephrine stimulus (GO:0071872)2.61914335
146positive regulation of action potential (GO:0045760)2.61663598
147enteric nervous system development (GO:0048484)2.61645453
148glial cell development (GO:0021782)2.60771734
149response to lead ion (GO:0010288)2.60500445
150positive regulation of glial cell differentiation (GO:0045687)2.57982696
151regulation of catecholamine metabolic process (GO:0042069)2.55033463
152regulation of dopamine metabolic process (GO:0042053)2.55033463
153peripheral nervous system development (GO:0007422)2.54918962
154adult locomotory behavior (GO:0008344)2.54468180
155detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.52978056
156detection of temperature stimulus involved in sensory perception (GO:0050961)2.52978056
157negative regulation of macroautophagy (GO:0016242)2.52644972
158gamma-aminobutyric acid transport (GO:0015812)2.52300669
159iron coordination entity transport (GO:1901678)2.51950330
160Golgi to endosome transport (GO:0006895)2.51572508
161regulation of interleukin-13 production (GO:0032656)2.49697531
162regulation of voltage-gated calcium channel activity (GO:1901385)2.48440981
163positive regulation of gliogenesis (GO:0014015)2.47771322
164negative regulation of execution phase of apoptosis (GO:1900118)2.47280321
165neural nucleus development (GO:0048857)2.46285098
166gamma-aminobutyric acid signaling pathway (GO:0007214)2.46277627
167protein localization to endosome (GO:0036010)2.43876640
168negative regulation of acute inflammatory response (GO:0002674)2.43389402
169negative regulation of axon extension (GO:0030517)2.42798573
170synaptic vesicle exocytosis (GO:0016079)2.42531215
171cellular response to catecholamine stimulus (GO:0071870)2.41161487
172central nervous system myelination (GO:0022010)11.4792234
173axon ensheathment in central nervous system (GO:0032291)11.4792234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.25618764
2EZH2_22144423_ChIP-Seq_EOC_Human3.00602763
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65567000
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.62171791
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61189299
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.43526154
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36469896
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.27366309
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.27366309
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26546525
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26062520
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21026603
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19477984
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15837427
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.13568575
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06780804
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03486979
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02798863
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.02404867
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.02311947
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98408711
22TAF15_26573619_Chip-Seq_HEK293_Human1.98348648
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92479069
24DROSHA_22980978_ChIP-Seq_HELA_Human1.92262257
25AR_21572438_ChIP-Seq_LNCaP_Human1.87476945
26OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86375635
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.80405541
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71473353
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.70749375
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68716283
31RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.68712152
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.62030207
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56354675
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49821000
35REST_21632747_ChIP-Seq_MESCs_Mouse1.49251065
36ER_23166858_ChIP-Seq_MCF-7_Human1.49206186
37KDM2B_26808549_Chip-Seq_K562_Human1.47224017
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46024962
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45121274
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44801743
41ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39971408
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.38482508
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.36989016
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36040238
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34157390
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34029568
47VDR_22108803_ChIP-Seq_LS180_Human1.33481609
48STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32060145
49REST_18959480_ChIP-ChIP_MESCs_Mouse1.29271971
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28211303
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26478528
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26365724
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25708524
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24480175
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24385463
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22981973
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21144544
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.19354702
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.18485538
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18407694
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18201098
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.18024413
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17682711
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17118858
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16921890
66AR_19668381_ChIP-Seq_PC3_Human1.16734331
67TET1_21490601_ChIP-Seq_MESCs_Mouse1.16326456
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16035953
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15194336
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14995122
71P300_19829295_ChIP-Seq_ESCs_Human1.14653389
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14608449
73NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11405697
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11405697
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11213415
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09086587
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08885606
78STAT3_23295773_ChIP-Seq_U87_Human1.08688645
79CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08625891
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06605741
81SMAD4_21799915_ChIP-Seq_A2780_Human1.05034814
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.04525036
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04319683
84LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03753812
85EOMES_21245162_ChIP-Seq_HESCs_Human1.03569254
86CTCF_27219007_Chip-Seq_Bcells_Human1.03031542
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.01484807
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00974481
89SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.97981544
90TAL1_26923725_Chip-Seq_HPCs_Mouse0.97595021
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97582609
92GATA1_26923725_Chip-Seq_HPCs_Mouse0.97112742
93OCT4_19829295_ChIP-Seq_ESCs_Human0.96757032
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96692314
95TCF4_23295773_ChIP-Seq_U87_Human0.96506483
96RING1B_27294783_Chip-Seq_ESCs_Mouse0.96480383
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96144986
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95116202
99PRDM14_20953172_ChIP-Seq_ESCs_Human0.94639266
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94273604
101YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94002031
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92702509
103CMYC_18555785_Chip-Seq_ESCs_Mouse0.92265432
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92134750
105RNF2_27304074_Chip-Seq_NSC_Mouse0.91849986
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91716580
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.91499092
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90740320
109NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90651837
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90303655
111RING1B_27294783_Chip-Seq_NPCs_Mouse0.89687040
112NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89603105
113AHR_22903824_ChIP-Seq_MCF-7_Human0.89458789
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89302858
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.89259313
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89185399
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88966232
118FUS_26573619_Chip-Seq_HEK293_Human0.88724451
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88638828
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88097894
121HTT_18923047_ChIP-ChIP_STHdh_Human0.87422133
122SOX2_21211035_ChIP-Seq_LN229_Gbm0.86757134
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.86076678
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85904311
125LXR_22292898_ChIP-Seq_THP-1_Human0.85166451
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.84818960
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84774170
128TBL1_22424771_ChIP-Seq_293T_Human0.84722748
129SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84441311
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.83761380
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.83745194
132DPY_21335234_ChIP-Seq_ESCs_Mouse0.82934414
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82572410
134KLF4_19829295_ChIP-Seq_ESCs_Human0.76693100
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.75679806
136SMC4_20622854_ChIP-Seq_HELA_Human0.75306650
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75084783
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.75084783
139EGR1_19032775_ChIP-ChIP_M12_Human0.74551505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.18860572
2MP0003880_abnormal_central_pattern4.17540078
3MP0004270_analgesia3.46610757
4MP0003950_abnormal_plasma_membrane3.36230344
5MP0004859_abnormal_synaptic_plasticity3.02655766
6MP0003690_abnormal_glial_cell2.91179123
7MP0002272_abnormal_nervous_system2.84745804
8MP0004885_abnormal_endolymph2.72947261
9MP0003329_amyloid_beta_deposits2.67113785
10MP0005171_absent_coat_pigmentation2.66854950
11MP0001486_abnormal_startle_reflex2.65631987
12MP0001529_abnormal_vocalization2.58342034
13MP0002064_seizures2.57663562
14MP0004142_abnormal_muscle_tone2.42367157
15MP0004742_abnormal_vestibular_system2.36558818
16MP0009046_muscle_twitch2.36324512
17MP0003635_abnormal_synaptic_transmissio2.31734423
18MP0003634_abnormal_glial_cell2.28834064
19MP0001905_abnormal_dopamine_level2.26272881
20MP0005423_abnormal_somatic_nervous2.24318701
21MP0009745_abnormal_behavioral_response2.17757748
22MP0003879_abnormal_hair_cell2.16204917
23MP0003136_yellow_coat_color2.04609786
24MP0000778_abnormal_nervous_system2.01540711
25MP0002734_abnormal_mechanical_nocicepti1.98270682
26MP0004043_abnormal_pH_regulation1.90811243
27MP0001485_abnormal_pinna_reflex1.89210219
28MP0002229_neurodegeneration1.88803053
29MP0009780_abnormal_chondrocyte_physiolo1.87003708
30MP0005410_abnormal_fertilization1.84268333
31MP0008569_lethality_at_weaning1.79533235
32MP0003632_abnormal_nervous_system1.74873346
33MP0003787_abnormal_imprinting1.66856502
34MP0002063_abnormal_learning/memory/cond1.65916138
35MP0002572_abnormal_emotion/affect_behav1.64802398
36MP0005409_darkened_coat_color1.64475827
37MP0000955_abnormal_spinal_cord1.58268273
38MP0001984_abnormal_olfaction1.51281718
39MP0001440_abnormal_grooming_behavior1.51148789
40MP0003631_nervous_system_phenotype1.50350625
41MP0001970_abnormal_pain_threshold1.45309664
42MP0002067_abnormal_sensory_capabilities1.45004669
43MP0005551_abnormal_eye_electrophysiolog1.44973262
44MP0002882_abnormal_neuron_morphology1.42451466
45MP0003633_abnormal_nervous_system1.40536297
46MP0006276_abnormal_autonomic_nervous1.39180981
47MP0002066_abnormal_motor_capabilities/c1.38009840
48MP0004381_abnormal_hair_follicle1.36800142
49MP0004147_increased_porphyrin_level1.36514948
50MP0005386_behavior/neurological_phenoty1.33627393
51MP0004924_abnormal_behavior1.33627393
52MP0005167_abnormal_blood-brain_barrier1.32574507
53MP0000604_amyloidosis1.30793315
54MP0008260_abnormal_autophagy1.29161335
55MP0010678_abnormal_skin_adnexa1.28081562
56MP0000462_abnormal_digestive_system1.25321637
57MP0000747_muscle_weakness1.24735750
58MP0002822_catalepsy1.23742182
59MP0005623_abnormal_meninges_morphology1.23359395
60MP0001968_abnormal_touch/_nociception1.22591968
61MP0005451_abnormal_body_composition1.22145583
62MP0004145_abnormal_muscle_electrophysio1.20366853
63MP0002733_abnormal_thermal_nociception1.20200697
64MP0001963_abnormal_hearing_physiology1.15496603
65MP0000383_abnormal_hair_follicle1.12960350
66MP0002752_abnormal_somatic_nervous1.10188232
67MP0001299_abnormal_eye_distance/1.08526427
68MP0003806_abnormal_nucleotide_metabolis1.08475982
69MP0003123_paternal_imprinting1.07866421
70MP0003122_maternal_imprinting1.07618616
71MP0001346_abnormal_lacrimal_gland1.04786995
72MP0004134_abnormal_chest_morphology1.04493622
73MP0001501_abnormal_sleep_pattern1.01650692
74MP0008874_decreased_physiological_sensi1.01285942
75MP0003075_altered_response_to1.00184852
76MP0001502_abnormal_circadian_rhythm0.98744299
77MP0002736_abnormal_nociception_after0.97936051
78MP0001177_atelectasis0.97325450
79MP0002735_abnormal_chemical_nociception0.95541280
80MP0002184_abnormal_innervation0.91356584
81MP0002152_abnormal_brain_morphology0.88052752
82MP0005195_abnormal_posterior_eye0.87340440
83MP0000566_synostosis0.85532361
84MP0002638_abnormal_pupillary_reflex0.84227643
85MP0002557_abnormal_social/conspecific_i0.82404356
86MP0005058_abnormal_lysosome_morphology0.81644464
87MP0004811_abnormal_neuron_physiology0.81355781
88MP0001986_abnormal_taste_sensitivity0.79206598
89MP0001851_eye_inflammation0.78779141
90MP0005535_abnormal_body_temperature0.78770677
91MP0001661_extended_life_span0.74913370
92MP0003137_abnormal_impulse_conducting0.73886041
93MP0003195_calcinosis0.73864389
94MP0004036_abnormal_muscle_relaxation0.72909337
95MP0004130_abnormal_muscle_cell0.72114067
96MP0000647_abnormal_sebaceous_gland0.71504140
97MP0000749_muscle_degeneration0.71138631
98MP0001348_abnormal_lacrimal_gland0.71036313
99MP0005253_abnormal_eye_physiology0.70806872
100MP0002090_abnormal_vision0.69628642
101MP0005646_abnormal_pituitary_gland0.69018414
102MP0002069_abnormal_eating/drinking_beha0.67771731
103MP0006072_abnormal_retinal_apoptosis0.67371891
104MP0000579_abnormal_nail_morphology0.67196461
105MP0000026_abnormal_inner_ear0.67031956
106MP0003938_abnormal_ear_development0.66372878
107MP0005645_abnormal_hypothalamus_physiol0.65188504
108MP0008872_abnormal_physiological_respon0.65074096
109MP0009840_abnormal_foam_cell0.64472875
110MP0000003_abnormal_adipose_tissue0.63691834
111MP0002909_abnormal_adrenal_gland0.63595715
112MP0002295_abnormal_pulmonary_circulatio0.62756990
113MP0000762_abnormal_tongue_morphology0.61046650
114MP0010386_abnormal_urinary_bladder0.60396209
115MP0004085_abnormal_heartbeat0.59533180
116MP0003045_fibrosis0.58622042
117MP0000639_abnormal_adrenal_gland0.58047431
118MP0000751_myopathy0.56510753
119MP0002133_abnormal_respiratory_system0.55708934
120MP0004215_abnormal_myocardial_fiber0.55154972
121MP0004510_myositis0.54696883
122MP0010769_abnormal_survival0.52953177
123MP0008877_abnormal_DNA_methylation0.51190730
124MP0000569_abnormal_digit_pigmentation0.50437970
125MP0010768_mortality/aging0.49267044
126MP0002082_postnatal_lethality0.48031531
127MP0010770_preweaning_lethality0.48031531
128MP0001943_abnormal_respiration0.46357778
129MP0005166_decreased_susceptibility_to0.45904331
130MP0003956_abnormal_body_size0.45308896
131MP0002089_abnormal_postnatal_growth/wei0.43636433

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)6.12079262
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.08544463
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.08544463
4Febrile seizures (HP:0002373)5.25694637
5Abnormality of binocular vision (HP:0011514)4.86529936
6Diplopia (HP:0000651)4.86529936
7Peripheral hypomyelination (HP:0007182)4.74665311
8Abnormality of the corticospinal tract (HP:0002492)4.70646969
9Cerebral hypomyelination (HP:0006808)4.63556093
10Cerebral inclusion bodies (HP:0100314)4.37116547
11Sensory axonal neuropathy (HP:0003390)4.32819578
12Myokymia (HP:0002411)4.09971794
13Onion bulb formation (HP:0003383)4.08043603
14Supranuclear gaze palsy (HP:0000605)4.06866737
15Parakeratosis (HP:0001036)3.96605412
16Abnormal auditory evoked potentials (HP:0006958)3.86065779
17Abnormal eating behavior (HP:0100738)3.78851346
18Progressive cerebellar ataxia (HP:0002073)3.71978002
19Spastic gait (HP:0002064)3.70684267
20Generalized tonic-clonic seizures (HP:0002069)3.70611637
21Visual hallucinations (HP:0002367)3.70119730
22Intention tremor (HP:0002080)3.59103437
23Dysmetria (HP:0001310)3.57405634
24Postural instability (HP:0002172)3.49264057
25Alacrima (HP:0000522)3.45576582
26Absence seizures (HP:0002121)3.36461688
27Ankle clonus (HP:0011448)3.35390821
28Hemiplegia (HP:0002301)3.33450924
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.31195110
30Scanning speech (HP:0002168)3.30274979
31Dialeptic seizures (HP:0011146)3.26775788
32Urinary bladder sphincter dysfunction (HP:0002839)3.26509919
33Torticollis (HP:0000473)3.26030567
34Obstructive sleep apnea (HP:0002870)3.18913047
35Annular pancreas (HP:0001734)3.17085029
36Mutism (HP:0002300)3.16438863
37Papilledema (HP:0001085)3.14575743
38Truncal ataxia (HP:0002078)3.14493807
39Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.12544945
40Tetraplegia (HP:0002445)3.08015418
41Leukodystrophy (HP:0002415)3.06897931
42Termporal pattern (HP:0011008)2.97907796
43Insidious onset (HP:0003587)2.97907796
44CNS hypomyelination (HP:0003429)2.96128109
45Impaired vibration sensation in the lower limbs (HP:0002166)2.91629335
46Slow saccadic eye movements (HP:0000514)2.83671491
47Hemiparesis (HP:0001269)2.78083959
48Focal motor seizures (HP:0011153)2.77477530
49Delusions (HP:0000746)2.75604310
50Thickened helices (HP:0000391)2.73438449
51Focal dystonia (HP:0004373)2.71735508
52Segmental peripheral demyelination/remyelination (HP:0003481)2.70332908
53Depression (HP:0000716)2.69883406
54Decreased lacrimation (HP:0000633)2.69007965
55Retinal dysplasia (HP:0007973)2.67254308
56Status epilepticus (HP:0002133)2.66312258
57Anxiety (HP:0000739)2.60258935
58Clumsiness (HP:0002312)2.59498797
59Poor eye contact (HP:0000817)2.56630511
60Spastic paraparesis (HP:0002313)2.55425762
61Sleep apnea (HP:0010535)2.55077267
62Bradykinesia (HP:0002067)2.54817267
63Pheochromocytoma (HP:0002666)2.54252023
64Craniofacial dystonia (HP:0012179)2.52713378
65Action tremor (HP:0002345)2.52492675
66Bundle branch block (HP:0011710)2.51436744
67Cerebral hemorrhage (HP:0001342)2.49688913
68Split foot (HP:0001839)2.49230921
69Rigidity (HP:0002063)2.46980791
70Spastic tetraparesis (HP:0001285)2.43588073
71Absent septum pellucidum (HP:0001331)2.41898172
72Anteriorly placed anus (HP:0001545)2.41651100
73Epileptiform EEG discharges (HP:0011182)2.40345168
74Morphological abnormality of the inner ear (HP:0011390)2.40201896
75Megalencephaly (HP:0001355)2.40033838
76Muscle fiber splitting (HP:0003555)2.39260750
77Abnormality of the lower motor neuron (HP:0002366)2.37662981
78Foot dorsiflexor weakness (HP:0009027)2.37387817
79Abnormality of glycolysis (HP:0004366)2.34131167
80Increased serum pyruvate (HP:0003542)2.34131167
81Lower limb muscle weakness (HP:0007340)2.33788534
82Apathy (HP:0000741)2.33242871
83Akinesia (HP:0002304)2.32298603
84Hypoplastic pelvis (HP:0008839)2.30995785
85Aplasia involving bones of the extremities (HP:0009825)2.29880283
86Aplasia involving bones of the upper limbs (HP:0009823)2.29880283
87Aplasia of the phalanges of the hand (HP:0009802)2.29880283
88Increased circulating renin level (HP:0000848)2.29874467
89Premature skin wrinkling (HP:0100678)2.29789967
90Metabolic alkalosis (HP:0200114)2.29605580
91Rapidly progressive (HP:0003678)2.29471228
92Poor speech (HP:0002465)2.29324714
93Impaired smooth pursuit (HP:0007772)2.29280677
94Insomnia (HP:0100785)2.29051483
95Stridor (HP:0010307)2.23033913
96White forelock (HP:0002211)2.21997322
97Choreoathetosis (HP:0001266)2.19694852
98Neuroendocrine neoplasm (HP:0100634)2.18754872
99Axonal loss (HP:0003447)2.18718833
100Abnormal social behavior (HP:0012433)2.16830281
101Impaired social interactions (HP:0000735)2.16830281
102Polyphagia (HP:0002591)2.16569644
103Abnormality of ocular smooth pursuit (HP:0000617)2.15263891
104Abnormality of the foot musculature (HP:0001436)2.14883014
105Impaired vibratory sensation (HP:0002495)2.14236042
106Abnormality of the periventricular white matter (HP:0002518)2.12103966
107Limb dystonia (HP:0002451)2.11465485
108Patchy hypopigmentation of hair (HP:0011365)2.11025922
109Congenital ichthyosiform erythroderma (HP:0007431)2.10911931
110Autoamputation (HP:0001218)2.09524011
111Epileptic encephalopathy (HP:0200134)2.09417624
112EEG with generalized epileptiform discharges (HP:0011198)2.09143792
113Clonus (HP:0002169)2.08107281
114Decreased motor nerve conduction velocity (HP:0003431)2.05550842
115Hypokalemic alkalosis (HP:0001949)2.05498051
116Paraparesis (HP:0002385)2.05187645
117Diminished motivation (HP:0000745)2.04846466
118Hypoplasia of the iris (HP:0007676)2.04760647
119Atonic seizures (HP:0010819)2.03100907
120Focal seizures (HP:0007359)2.02707819
121Stereotypic behavior (HP:0000733)2.02690566
122Dysdiadochokinesis (HP:0002075)2.02403697
123Methylmalonic acidemia (HP:0002912)2.02247180
124Heart block (HP:0012722)2.02100320
125Abnormality of the septum pellucidum (HP:0007375)2.00331329
126Ventricular fibrillation (HP:0001663)2.00015388
127Coronal craniosynostosis (HP:0004440)1.99900669
128Urinary urgency (HP:0000012)1.99671116
129Abnormality of the phalanges of the 2nd finger (HP:0009541)1.99086685
130Hypomagnesemia (HP:0002917)1.96843970
131Amblyopia (HP:0000646)1.93954008
132Hypsarrhythmia (HP:0002521)1.93888389
133Fetal akinesia sequence (HP:0001989)1.92292550
134Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90912055
135Gowers sign (HP:0003391)1.90224147
136Hyporeflexia of lower limbs (HP:0002600)1.89914712
137Synostosis involving the elbow (HP:0003938)1.88619824
138Humeroradial synostosis (HP:0003041)1.88619824
139Broad-based gait (HP:0002136)1.88246907
140Urinary incontinence (HP:0000020)1.88148953
141Abnormality of saccadic eye movements (HP:0000570)1.87561376
142Slow progression (HP:0003677)1.87300704
143Distal sensory impairment (HP:0002936)1.87086464
144Gaze-evoked nystagmus (HP:0000640)1.87014515
145Morphological abnormality of the pyramidal tract (HP:0002062)1.86435454
146Incomplete penetrance (HP:0003829)1.84770122
147Bowel incontinence (HP:0002607)1.84604353
148Memory impairment (HP:0002354)1.83882473
149Hepatosplenomegaly (HP:0001433)1.83617363
150Infantile muscular hypotonia (HP:0008947)1.83381169
151Neuronal loss in central nervous system (HP:0002529)1.83200167
152Lower limb amyotrophy (HP:0007210)1.83165348
153Abnormal atrioventricular conduction (HP:0005150)1.83122321
154Spastic paraplegia (HP:0001258)1.82532137
155Hammertoe (HP:0001765)1.80533119
156Generalized myoclonic seizures (HP:0002123)1.75000769
157Peripheral demyelination (HP:0011096)1.74173410
158Abnormality of the middle phalanges of the toes (HP:0010183)1.74126408
159Abnormal large intestine physiology (HP:0012700)1.70152277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.74078701
2OXSR14.34656920
3PKN12.84532732
4EPHB12.83368630
5CDK192.67869255
6BCR2.63014340
7MAPKAPK52.38413493
8WNK42.32678745
9CAMKK12.26029184
10PRPF4B2.23147718
11FGFR22.21381119
12WNK12.14320675
13LIMK12.04295459
14MET2.00648861
15RIPK11.95637251
16PBK1.93603042
17UHMK11.92272064
18CAMK2B1.79220882
19NEK61.78455372
20CSNK1G31.76909727
21CSNK1A1L1.72837656
22PLK21.72354842
23NTRK11.62685415
24PNCK1.60223321
25TNIK1.59379515
26ROCK21.57084801
27PAK61.54491076
28EPHA41.54382768
29SGK4941.50589273
30SGK2231.50589273
31TESK21.50072472
32RIPK41.46550901
33CAMK2D1.45332864
34CSNK1G21.39917171
35CAMK11.38620424
36CSNK1G11.33669466
37CASK1.30946544
38CAMK2G1.25671520
39MARK11.19730037
40ICK1.19578780
41TYRO31.15144351
42FGR1.14413151
43SGK21.13982190
44DAPK11.13254941
45LATS21.11083489
46CLK11.08488858
47CAMKK21.06663673
48SIK21.01446237
49CDK51.00752196
50MST40.99722852
51PHKG10.99491877
52PHKG20.99491877
53CAMK2A0.95123348
54SGK30.95003463
55CDK140.94018617
56MAPK120.93544926
57STK380.92369417
58ALK0.91996476
59MARK20.91305048
60ARAF0.91196071
61CDK150.86777872
62MAP3K130.84327496
63KSR20.82662736
64PRKD10.81986540
65DYRK20.81445539
66CDK180.81264966
67PAK30.79769102
68MUSK0.77479041
69CDK11A0.77381231
70NTRK20.76453868
71PRKCQ0.75212457
72PDPK10.74910237
73PRKCH0.72812527
74TRPM70.72756337
75NTRK30.72003927
76MAP3K90.70608562
77PRKCE0.69946151
78PINK10.69743817
79PRKD30.69009089
80TNK20.67430293
81RPS6KA30.64655351
82CAMK40.63283341
83BMPR1B0.63153741
84MAP3K110.62781163
85BRSK10.60606755
86MAPK150.58968650
87FYN0.56053497
88LMTK20.53183340
89PRKG10.51826255
90DAPK30.50349165
91STK110.50329449
92PRKCZ0.49960795
93IRAK20.49441342
94MAPK130.46987985
95PRKACB0.46905992
96CSNK1A10.46841031
97KSR10.46804295
98MAP2K40.46798223
99CSNK1D0.45876156
100PDK10.44241697
101FES0.43221291
102ROCK10.43169359
103PTK2B0.43008377
104BRAF0.42189148
105DAPK20.42087259
106RET0.41421488
107MINK10.40043596
108CAMK1G0.39735001
109MAP3K20.39535167
110ERBB40.39381550
111ERBB20.38972651
112PRKCA0.38337154
113GSK3A0.38052849
114DMPK0.37542955
115RAF10.37201982
116TESK10.34161234
117PAK10.33579666
118MAP3K40.33573078
119MAP2K20.32878956
120BMX0.32722477
121PRKACA0.32544946
122DYRK1A0.32162891
123MAP3K10.31942223
124MAPK70.31750646
125RPS6KA50.31242563
126PRKCG0.30881376
127BMPR20.30600290
128PRKG20.30318548
129SRC0.29942926
130MAPK100.29781081
131MAP2K70.29546744
132JAK20.29300831
133PRKCB0.28966162
134GRK50.26841390
135SGK10.26612616
136PDGFRB0.26113887
137PIK3CA0.26039654

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.39989113
2Fatty acid elongation_Homo sapiens_hsa000623.79898881
3Steroid biosynthesis_Homo sapiens_hsa001003.43923961
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72057962
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59960366
6Ether lipid metabolism_Homo sapiens_hsa005652.53608991
7Nitrogen metabolism_Homo sapiens_hsa009102.47322225
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.40565109
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.21478951
10Vitamin B6 metabolism_Homo sapiens_hsa007502.11003422
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04127029
12GABAergic synapse_Homo sapiens_hsa047271.98322497
13Glutamatergic synapse_Homo sapiens_hsa047241.77444295
14Oxidative phosphorylation_Homo sapiens_hsa001901.75214910
15Sulfur metabolism_Homo sapiens_hsa009201.71783265
16Axon guidance_Homo sapiens_hsa043601.70287947
17Morphine addiction_Homo sapiens_hsa050321.62804791
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54491939
19Nicotine addiction_Homo sapiens_hsa050331.47842462
20Sphingolipid metabolism_Homo sapiens_hsa006001.47356383
21Serotonergic synapse_Homo sapiens_hsa047261.40796044
22Histidine metabolism_Homo sapiens_hsa003401.38923161
23Long-term depression_Homo sapiens_hsa047301.37218079
24Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.36864446
25Synaptic vesicle cycle_Homo sapiens_hsa047211.36838713
26Circadian entrainment_Homo sapiens_hsa047131.34056075
27Linoleic acid metabolism_Homo sapiens_hsa005911.27078353
28Alzheimers disease_Homo sapiens_hsa050101.26739794
29Parkinsons disease_Homo sapiens_hsa050121.26729834
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22611561
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22354082
32Protein export_Homo sapiens_hsa030601.22271793
33Butanoate metabolism_Homo sapiens_hsa006501.21744854
34GnRH signaling pathway_Homo sapiens_hsa049121.18204587
35Collecting duct acid secretion_Homo sapiens_hsa049661.17922002
36Estrogen signaling pathway_Homo sapiens_hsa049151.17882616
37Salivary secretion_Homo sapiens_hsa049701.17128911
38Bile secretion_Homo sapiens_hsa049761.15974888
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15135870
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13174033
41Cocaine addiction_Homo sapiens_hsa050301.11889232
42Gastric acid secretion_Homo sapiens_hsa049711.03057043
43Cardiac muscle contraction_Homo sapiens_hsa042601.01271817
44Arginine and proline metabolism_Homo sapiens_hsa003301.00969392
45Vibrio cholerae infection_Homo sapiens_hsa051101.00624626
46Glioma_Homo sapiens_hsa052140.99176446
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98438786
48Renal cell carcinoma_Homo sapiens_hsa052110.98248400
49Dopaminergic synapse_Homo sapiens_hsa047280.94731851
50Thyroid hormone synthesis_Homo sapiens_hsa049180.93512208
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91024512
52Cholinergic synapse_Homo sapiens_hsa047250.90206441
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.89049520
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.87880383
55Phototransduction_Homo sapiens_hsa047440.87522472
56Tight junction_Homo sapiens_hsa045300.87209161
57beta-Alanine metabolism_Homo sapiens_hsa004100.86654414
58Prion diseases_Homo sapiens_hsa050200.86646111
59Taste transduction_Homo sapiens_hsa047420.85623186
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82912539
61Olfactory transduction_Homo sapiens_hsa047400.82024872
62Endocytosis_Homo sapiens_hsa041440.81963484
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81850115
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.80906386
65Amphetamine addiction_Homo sapiens_hsa050310.80429284
66Renin secretion_Homo sapiens_hsa049240.77335328
67Rap1 signaling pathway_Homo sapiens_hsa040150.76000649
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73929784
69Long-term potentiation_Homo sapiens_hsa047200.73751025
70Gap junction_Homo sapiens_hsa045400.73582090
71Oocyte meiosis_Homo sapiens_hsa041140.72377025
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70884177
73Ras signaling pathway_Homo sapiens_hsa040140.70363366
74Pancreatic secretion_Homo sapiens_hsa049720.70285346
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68273445
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68245550
77Ovarian steroidogenesis_Homo sapiens_hsa049130.67054237
78MAPK signaling pathway_Homo sapiens_hsa040100.66936700
79Type II diabetes mellitus_Homo sapiens_hsa049300.66004449
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.65512750
81Mineral absorption_Homo sapiens_hsa049780.64506550
82cAMP signaling pathway_Homo sapiens_hsa040240.64115468
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.62857864
84Dorso-ventral axis formation_Homo sapiens_hsa043200.62695208
85Rheumatoid arthritis_Homo sapiens_hsa053230.61671376
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60499444
87Lysosome_Homo sapiens_hsa041420.59853509
88Arachidonic acid metabolism_Homo sapiens_hsa005900.59691210
89Insulin secretion_Homo sapiens_hsa049110.58095802
90VEGF signaling pathway_Homo sapiens_hsa043700.57753359
91ErbB signaling pathway_Homo sapiens_hsa040120.57207775
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56732960
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55735518
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55039628
95Fatty acid metabolism_Homo sapiens_hsa012120.55037707
96Circadian rhythm_Homo sapiens_hsa047100.53375958
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53327142
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53010099
99Propanoate metabolism_Homo sapiens_hsa006400.52981261
100Calcium signaling pathway_Homo sapiens_hsa040200.52954354
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52616433
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52410982
103Huntingtons disease_Homo sapiens_hsa050160.51020110
104Dilated cardiomyopathy_Homo sapiens_hsa054140.50354531
105Oxytocin signaling pathway_Homo sapiens_hsa049210.50308686
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50192045
107Arginine biosynthesis_Homo sapiens_hsa002200.49972449
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49557133
109Glucagon signaling pathway_Homo sapiens_hsa049220.49268981
110Autoimmune thyroid disease_Homo sapiens_hsa053200.47739806
111Folate biosynthesis_Homo sapiens_hsa007900.44163449
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43631014
113Fatty acid biosynthesis_Homo sapiens_hsa000610.43561404
114Phagosome_Homo sapiens_hsa041450.43423223
115Glutathione metabolism_Homo sapiens_hsa004800.43355256
116Hedgehog signaling pathway_Homo sapiens_hsa043400.41977939
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40359463
118Choline metabolism in cancer_Homo sapiens_hsa052310.38342008
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37219351
120ABC transporters_Homo sapiens_hsa020100.37112127
121Inositol phosphate metabolism_Homo sapiens_hsa005620.36095983
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34900935
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34683192
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33537475
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.33454854
126Melanogenesis_Homo sapiens_hsa049160.33404877
127Alcoholism_Homo sapiens_hsa050340.32524213
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30833700
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30272590
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23266338
131AMPK signaling pathway_Homo sapiens_hsa041520.21744803
132Wnt signaling pathway_Homo sapiens_hsa043100.20100667
133mTOR signaling pathway_Homo sapiens_hsa041500.19461449
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18115169

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