SEPT7P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sarcomere organization (GO:0060297)5.96783184
2DNA deamination (GO:0045006)5.89759584
3respiratory chain complex IV assembly (GO:0008535)4.40967813
4negative regulation of nitric-oxide synthase activity (GO:0051001)4.38158503
5activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO4.11679094
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.09902655
7ribonucleoprotein complex disassembly (GO:0032988)4.06499792
8negative regulation of organelle assembly (GO:1902116)4.06346684
9embryonic viscerocranium morphogenesis (GO:0048703)3.93610917
10positive regulation of gastrulation (GO:2000543)3.90619490
11rRNA catabolic process (GO:0016075)3.83874615
12response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.83807790
13regulation of skeletal muscle contraction (GO:0014819)3.83607446
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82499495
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.82499495
16NADH dehydrogenase complex assembly (GO:0010257)3.82499495
17pericardium development (GO:0060039)3.74953289
18axoneme assembly (GO:0035082)3.74155599
19organelle disassembly (GO:1903008)3.73971733
20behavioral response to nicotine (GO:0035095)3.73385199
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.70899883
22protein polyglutamylation (GO:0018095)3.70456490
23DNA demethylation (GO:0080111)3.68419277
24negative regulation of telomere maintenance (GO:0032205)3.68123271
25adaptation of signaling pathway (GO:0023058)3.67226020
26cytochrome complex assembly (GO:0017004)3.64434370
27secondary heart field specification (GO:0003139)3.56428399
28heart field specification (GO:0003128)3.56428399
29head development (GO:0060322)3.55997602
30negative regulation of muscle hypertrophy (GO:0014741)3.53722972
31response to redox state (GO:0051775)3.48799901
32negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.44371664
33regulation of type B pancreatic cell apoptotic process (GO:2000674)3.39809954
34plasma membrane repair (GO:0001778)3.39729790
35protein complex biogenesis (GO:0070271)3.38523682
36protein neddylation (GO:0045116)3.36265658
37oxidative demethylation (GO:0070989)3.34186449
38cytidine metabolic process (GO:0046087)3.29783650
39cytidine catabolic process (GO:0006216)3.29783650
40cytidine deamination (GO:0009972)3.29783650
41regulation of action potential (GO:0098900)3.26725216
42positive regulation of microtubule polymerization (GO:0031116)3.23298000
43platelet dense granule organization (GO:0060155)3.20350036
44mitochondrial respiratory chain complex assembly (GO:0033108)3.19923516
45DNA dealkylation (GO:0035510)3.17098038
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14574631
47kidney morphogenesis (GO:0060993)3.07727362
48negative regulation of heart growth (GO:0061117)3.07134403
49negative regulation of cardiac muscle tissue growth (GO:0055022)3.07134403
50regulation of alkaline phosphatase activity (GO:0010692)3.06832380
51striated muscle atrophy (GO:0014891)3.04963366
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.04450429
53cornea development in camera-type eye (GO:0061303)3.03815749
54negative regulation of cardiac muscle hypertrophy (GO:0010614)3.03338844
55response to pheromone (GO:0019236)3.03311443
56rRNA modification (GO:0000154)3.02002850
57nodal signaling pathway (GO:0038092)3.01669343
58regulation of cilium movement (GO:0003352)2.97033944
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96857153
60negative regulation of potassium ion transmembrane transport (GO:1901380)2.95000825
61protein localization to cilium (GO:0061512)2.94531943
62positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.90964425
63protein targeting to vacuole (GO:0006623)2.88893837
64protein targeting to lysosome (GO:0006622)2.88893837
65establishment of protein localization to vacuole (GO:0072666)2.88893837
66intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.88762603
67multicellular organism reproduction (GO:0032504)2.87561745
68somite rostral/caudal axis specification (GO:0032525)2.86713187
69preassembly of GPI anchor in ER membrane (GO:0016254)2.85258469
70regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.85223202
71positive regulation of immune response to tumor cell (GO:0002839)2.82385344
72regulation of immune response to tumor cell (GO:0002837)2.82385344
73regulation of response to tumor cell (GO:0002834)2.82385344
74positive regulation of response to tumor cell (GO:0002836)2.82385344
75glomerulus development (GO:0032835)2.81755296
76protein K6-linked ubiquitination (GO:0085020)2.81282521
77glycerophospholipid catabolic process (GO:0046475)2.79331099
78cellular ketone body metabolic process (GO:0046950)2.78467918
79negative regulation of interleukin-1 beta production (GO:0032691)2.78137624
80membrane raft organization (GO:0031579)2.78117180
81regulation of membrane repolarization (GO:0060306)2.77805756
82adult feeding behavior (GO:0008343)2.75307064
83negative regulation of protein localization to cell surface (GO:2000009)2.71414251
84replication fork processing (GO:0031297)2.70561005
85maturation of 5.8S rRNA (GO:0000460)2.69447262
86nephron epithelium morphogenesis (GO:0072088)2.69241919
87nephron tubule morphogenesis (GO:0072078)2.69241919
88rRNA methylation (GO:0031167)2.69102944
89regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.67143488
90pyrimidine ribonucleoside catabolic process (GO:0046133)2.66938382
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65773824
92short-term memory (GO:0007614)2.65314540
93cellular response to interferon-beta (GO:0035458)2.64926535
94muscle atrophy (GO:0014889)2.64332955
95retina layer formation (GO:0010842)2.63658935
96NAD biosynthetic process (GO:0009435)2.63252976
97negative regulation of transcription regulatory region DNA binding (GO:2000678)2.63194958
98renal tubule morphogenesis (GO:0061333)2.62242655
99nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61213455
100pseudouridine synthesis (GO:0001522)2.61174419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human5.38563950
2ZNF274_21170338_ChIP-Seq_K562_Hela3.73248865
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89890298
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67278877
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.54479654
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50294414
7GBX2_23144817_ChIP-Seq_PC3_Human2.47012730
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.44701674
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36823621
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24491632
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.22593326
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06769949
13P300_19829295_ChIP-Seq_ESCs_Human2.05329588
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04569845
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.04067924
16FUS_26573619_Chip-Seq_HEK293_Human1.97271397
17ELK1_19687146_ChIP-ChIP_HELA_Human1.94705575
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93922382
19ER_23166858_ChIP-Seq_MCF-7_Human1.91071852
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88749791
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.88238782
22EWS_26573619_Chip-Seq_HEK293_Human1.86887936
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86751173
24CBP_20019798_ChIP-Seq_JUKART_Human1.84263525
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.84263525
26GATA1_22025678_ChIP-Seq_K562_Human1.76862630
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75572286
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75518444
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.73191191
30IGF1R_20145208_ChIP-Seq_DFB_Human1.70691074
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67202539
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59511668
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.50434811
34SMAD4_21799915_ChIP-Seq_A2780_Human1.50173214
35BCAT_22108803_ChIP-Seq_LS180_Human1.46016433
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44781861
37VDR_23849224_ChIP-Seq_CD4+_Human1.43456009
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42583222
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.41864213
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39211820
41NANOG_19829295_ChIP-Seq_ESCs_Human1.36681840
42SOX2_19829295_ChIP-Seq_ESCs_Human1.36681840
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.35987097
44STAT3_23295773_ChIP-Seq_U87_Human1.34416137
45KLF5_20875108_ChIP-Seq_MESCs_Mouse1.34191496
46IRF1_19129219_ChIP-ChIP_H3396_Human1.32690439
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31692696
48GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31298633
49TCF4_22108803_ChIP-Seq_LS180_Human1.30973589
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.30919096
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30544601
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30245959
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29887791
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29866769
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28880182
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26330182
57MYC_18940864_ChIP-ChIP_HL60_Human1.25389640
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.22761571
59TCF4_23295773_ChIP-Seq_U87_Human1.20426734
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19910517
61CDX2_22108803_ChIP-Seq_LS180_Human1.19116903
62TP53_22573176_ChIP-Seq_HFKS_Human1.18836820
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18179813
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.18117415
65NCOR_22424771_ChIP-Seq_293T_Human1.17422073
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.15439801
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.14355383
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.14161765
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12234147
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10951990
71STAT3_18555785_Chip-Seq_ESCs_Mouse1.09315844
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09282345
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.08719565
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.08477009
75P53_22387025_ChIP-Seq_ESCs_Mouse1.08316917
76HOXB7_26014856_ChIP-Seq_BT474_Human1.07762992
77AR_20517297_ChIP-Seq_VCAP_Human1.06732068
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06675355
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06608621
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.05670980
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05144544
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05144544
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03832319
84ETS1_20019798_ChIP-Seq_JURKAT_Human1.02728930
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02506396
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02272934
87SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01973661
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.01877866
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01845988
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99250143
91GATA3_26560356_Chip-Seq_TH2_Human0.99120207
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98415553
93TP53_16413492_ChIP-PET_HCT116_Human0.98411587
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98039176
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.97994382
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97994382
97P300_18555785_Chip-Seq_ESCs_Mouse0.97101182
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96986531
99RUNX2_22187159_ChIP-Seq_PCA_Human0.96380249
100OCT4_21477851_ChIP-Seq_ESCs_Mouse0.94888628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.08327626
2MP0002102_abnormal_ear_morphology4.49884146
3MP0002163_abnormal_gland_morphology3.88046374
4MP0002653_abnormal_ependyma_morphology3.29694389
5MP0002876_abnormal_thyroid_physiology3.15656895
6MP0005379_endocrine/exocrine_gland_phen2.85708457
7MP0001986_abnormal_taste_sensitivity2.80749292
8MP0000372_irregular_coat_pigmentation2.57055101
9MP0002837_dystrophic_cardiac_calcinosis2.51081222
10MP0004142_abnormal_muscle_tone2.43356238
11MP0008872_abnormal_physiological_respon2.39463452
12MP0001984_abnormal_olfaction2.34229875
13MP0003646_muscle_fatigue2.13178213
14MP0003806_abnormal_nucleotide_metabolis2.12996383
15MP0003195_calcinosis2.02469520
16MP0008877_abnormal_DNA_methylation2.02142173
17MP0009780_abnormal_chondrocyte_physiolo1.96994968
18MP0000427_abnormal_hair_cycle1.95326364
19MP0003122_maternal_imprinting1.94524936
20MP0004145_abnormal_muscle_electrophysio1.90495567
21MP0001440_abnormal_grooming_behavior1.90092509
22MP0002938_white_spotting1.74958713
23MP0001661_extended_life_span1.72108850
24MP0009046_muscle_twitch1.59933936
25MP0000749_muscle_degeneration1.57365551
26MP0003121_genomic_imprinting1.52057457
27MP0005394_taste/olfaction_phenotype1.49913678
28MP0005499_abnormal_olfactory_system1.49913678
29MP0008789_abnormal_olfactory_epithelium1.46572417
30MP0001919_abnormal_reproductive_system1.45779328
31MP0000685_abnormal_immune_system1.45770029
32MP0005551_abnormal_eye_electrophysiolog1.44311140
33MP0000383_abnormal_hair_follicle1.38760549
34MP0005389_reproductive_system_phenotype1.32599089
35MP0005670_abnormal_white_adipose1.30737216
36MP0002095_abnormal_skin_pigmentation1.29259611
37MP0006276_abnormal_autonomic_nervous1.24448640
38MP0002160_abnormal_reproductive_system1.23728541
39MP0006292_abnormal_olfactory_placode1.19776194
40MP0002138_abnormal_hepatobiliary_system1.19133640
41MP0002277_abnormal_respiratory_mucosa1.18968172
42MP0006054_spinal_hemorrhage1.18089292
43MP0002928_abnormal_bile_duct1.13408849
44MP0005220_abnormal_exocrine_pancreas1.12153074
45MP0004147_increased_porphyrin_level1.09513544
46MP0006082_CNS_inflammation1.09502112
47MP0008875_abnormal_xenobiotic_pharmacok1.08532462
48MP0003186_abnormal_redox_activity1.05653510
49MP0005332_abnormal_amino_acid1.04331518
50MP0005646_abnormal_pituitary_gland1.03197684
51MP0003136_yellow_coat_color1.02965682
52MP0001293_anophthalmia1.01414861
53MP0009745_abnormal_behavioral_response0.99892772
54MP0003567_abnormal_fetal_cardiomyocyte0.97574043
55MP0003959_abnormal_lean_body0.97456632
56MP0004133_heterotaxia0.96695901
57MP0001486_abnormal_startle_reflex0.96297380
58MP0005084_abnormal_gallbladder_morpholo0.95606308
59MP0006072_abnormal_retinal_apoptosis0.93952615
60MP0004043_abnormal_pH_regulation0.93411559
61MP0000538_abnormal_urinary_bladder0.91414132
62MP0001529_abnormal_vocalization0.91315307
63MP0002272_abnormal_nervous_system0.90486573
64MP0003119_abnormal_digestive_system0.90169999
65MP0000631_abnormal_neuroendocrine_gland0.90069769
66MP0002693_abnormal_pancreas_physiology0.89259695
67MP0005075_abnormal_melanosome_morpholog0.89185856
68MP0001968_abnormal_touch/_nociception0.88523074
69MP0003868_abnormal_feces_composition0.88342323
70MP0004381_abnormal_hair_follicle0.87778372
71MP0000015_abnormal_ear_pigmentation0.86187965
72MP0003787_abnormal_imprinting0.82755374
73MP0010386_abnormal_urinary_bladder0.81797501
74MP0003183_abnormal_peptide_metabolism0.81765451
75MP0005448_abnormal_energy_balance0.80471970
76MP0004885_abnormal_endolymph0.79192605
77MP0005174_abnormal_tail_pigmentation0.78068553
78MP0008961_abnormal_basal_metabolism0.75816599
79MP0000230_abnormal_systemic_arterial0.75796908
80MP0003890_abnormal_embryonic-extraembry0.75412770
81MP0003011_delayed_dark_adaptation0.75193814
82MP0001485_abnormal_pinna_reflex0.75166690
83MP0002127_abnormal_cardiovascular_syste0.73067962
84MP0000026_abnormal_inner_ear0.72645265
85MP0005671_abnormal_response_to0.71399814
86MP0003283_abnormal_digestive_organ0.68537162
87MP0001764_abnormal_homeostasis0.67916802
88MP0002135_abnormal_kidney_morphology0.67697127
89MP0002734_abnormal_mechanical_nocicepti0.65238720
90MP0005410_abnormal_fertilization0.62812467
91MP0003866_abnormal_defecation0.62550495
92MP0000750_abnormal_muscle_regeneration0.62532753
93MP0002736_abnormal_nociception_after0.60529700
94MP0004215_abnormal_myocardial_fiber0.59606798
95MP0001756_abnormal_urination0.58991180
96MP0001664_abnormal_digestion0.58433771
97MP0001501_abnormal_sleep_pattern0.57769853
98MP0005266_abnormal_metabolism0.57412147
99MP0002067_abnormal_sensory_capabilities0.56372035
100MP0000569_abnormal_digit_pigmentation0.56248026

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.99116601
2Type 2 muscle fiber atrophy (HP:0003554)3.97923770
3Calf muscle hypertrophy (HP:0008981)3.88092909
4Molar tooth sign on MRI (HP:0002419)3.66599169
5Abnormality of midbrain morphology (HP:0002418)3.66599169
6Pancreatic fibrosis (HP:0100732)3.63621629
7Renal cortical cysts (HP:0000803)3.59942271
8Renal salt wasting (HP:0000127)3.59344372
9Abnormality of the renal cortex (HP:0011035)3.56945002
10Polyuria (HP:0000103)3.51809579
11Hypomagnesemia (HP:0002917)3.44561523
12Occipital encephalocele (HP:0002085)3.34190330
13Muscle hypertrophy of the lower extremities (HP:0008968)3.32802403
14Muscle fiber atrophy (HP:0100295)3.19269101
15True hermaphroditism (HP:0010459)3.19135313
16Abnormal pancreas size (HP:0012094)3.02749328
17Acute encephalopathy (HP:0006846)3.00448157
18Acute necrotizing encephalopathy (HP:0006965)2.92908687
19Medial flaring of the eyebrow (HP:0010747)2.80453003
20Alkalosis (HP:0001948)2.78652384
21Abnormal urine output (HP:0012590)2.77496605
22Chronic hepatic failure (HP:0100626)2.76834130
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76153965
24Febrile seizures (HP:0002373)2.74945985
25Metaphyseal dysplasia (HP:0100255)2.68174215
26Nephronophthisis (HP:0000090)2.66334689
27Exercise-induced muscle cramps (HP:0003710)2.59722956
28Abnormality of renal excretion (HP:0011036)2.59585457
293-Methylglutaconic aciduria (HP:0003535)2.59520112
30Hepatocellular necrosis (HP:0001404)2.56295648
31Congenital stationary night blindness (HP:0007642)2.55937587
32Progressive macrocephaly (HP:0004481)2.53962832
33Abnormality of the renal medulla (HP:0100957)2.53241106
34Abnormality of the labia minora (HP:0012880)2.53002237
35Autoimmune thrombocytopenia (HP:0001973)2.52891736
36Abnormality of magnesium homeostasis (HP:0004921)2.49992336
37Mitochondrial inheritance (HP:0001427)2.48786626
38Increased circulating renin level (HP:0000848)2.47486751
39Metabolic alkalosis (HP:0200114)2.45182939
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44944799
41Abnormality of alanine metabolism (HP:0010916)2.44944799
42Hyperalaninemia (HP:0003348)2.44944799
43Poor suck (HP:0002033)2.42653288
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.40626155
45Attenuation of retinal blood vessels (HP:0007843)2.40299217
46Hepatic necrosis (HP:0002605)2.39709692
47Cystic liver disease (HP:0006706)2.38327933
48Increased corneal curvature (HP:0100692)2.37287095
49Keratoconus (HP:0000563)2.37287095
50Increased CSF lactate (HP:0002490)2.36690902
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36299863
52Polyphagia (HP:0002591)2.33946241
53Tubular atrophy (HP:0000092)2.32786864
54Abnormal number of erythroid precursors (HP:0012131)2.32422888
55Abnormal rod and cone electroretinograms (HP:0008323)2.31732192
56Hyperglycinuria (HP:0003108)2.27186839
57Abolished electroretinogram (ERG) (HP:0000550)2.27082082
58Sclerocornea (HP:0000647)2.25702645
59Abnormality of cells of the erythroid lineage (HP:0012130)2.25515528
60Abnormal mitochondria in muscle tissue (HP:0008316)2.22617589
61Hyperglycinemia (HP:0002154)2.21256221
62Abnormality of proline metabolism (HP:0010907)2.18995051
63Hydroxyprolinuria (HP:0003080)2.18995051
64Hyponatremia (HP:0002902)2.16187720
65Optic disc pallor (HP:0000543)2.13472156
66Elevated erythrocyte sedimentation rate (HP:0003565)2.11096461
67Hypokalemic alkalosis (HP:0001949)2.09065910
68Gait imbalance (HP:0002141)2.08114701
69Abnormal ciliary motility (HP:0012262)2.05485133
70Aplasia/Hypoplasia of the tibia (HP:0005772)2.02491469
71Congenital primary aphakia (HP:0007707)2.01965827
72Chorioretinal atrophy (HP:0000533)2.00859770
73Pigmentary retinal degeneration (HP:0001146)1.97873971
74Respiratory failure (HP:0002878)1.97398557
75Rhinitis (HP:0012384)1.97381974
76Postaxial foot polydactyly (HP:0001830)1.95750011
77Absent/shortened dynein arms (HP:0200106)1.93931206
78Dynein arm defect of respiratory motile cilia (HP:0012255)1.93931206
79Shawl scrotum (HP:0000049)1.93888559
80CNS demyelination (HP:0007305)1.93554267
81Abnormal respiratory motile cilium physiology (HP:0012261)1.93340086
82Increased serum lactate (HP:0002151)1.90513597
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86011452
84Aplasia/Hypoplasia of the spleen (HP:0010451)1.85147567
85Anencephaly (HP:0002323)1.84796948
86Large eyes (HP:0001090)1.82572883
87Hypoplasia of the fovea (HP:0007750)1.80169978
88Aplasia/Hypoplasia of the fovea (HP:0008060)1.80169978
89Narrow forehead (HP:0000341)1.80086803
90Abnormality of renal resorption (HP:0011038)1.78846654
91Asplenia (HP:0001746)1.78536551
92Increased serum pyruvate (HP:0003542)1.78514850
93Oligodactyly (hands) (HP:0001180)1.77949336
94Limb hypertonia (HP:0002509)1.75958726
95Type II lissencephaly (HP:0007260)1.75102107
96Hyperactive renin-angiotensin system (HP:0000841)1.74045588
97Papilledema (HP:0001085)1.73877401
98Widely spaced teeth (HP:0000687)1.73629535
99Hypoplasia of the thymus (HP:0000778)1.73456456
100Genital tract atresia (HP:0001827)1.73012568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.91042838
2TAOK33.78121782
3MAP4K23.75537917
4CDK83.69404629
5FRK3.51613246
6WNK43.13371266
7BMPR1B2.70804996
8STK392.39818916
9NUAK12.35334147
10VRK22.13604260
11INSRR2.12036912
12MAPKAPK52.03490769
13BCR1.94931657
14TAF11.86673760
15PIK3CA1.82690059
16EIF2AK31.63271613
17GRK71.55585788
18GRK11.49132008
19TRIM281.47960886
20ADRBK21.46842670
21TSSK61.46643193
22AKT31.44688423
23DAPK21.41131440
24MELK1.40465692
25MUSK1.30872635
26TGFBR11.23445934
27TLK11.12815091
28CDK91.08177009
29TEC1.06013053
30DMPK1.05513344
31MOS1.04946102
32EPHA31.04486247
33DYRK21.02313933
34PRKCE1.01059938
35VRK10.99472189
36MAP3K120.98728594
37MAP3K20.97202770
38BCKDK0.96690995
39WNK10.96604833
40TXK0.95972381
41IKBKB0.95283691
42TNK20.90734955
43ACVR1B0.90183666
44PLK20.89339691
45KIT0.85992193
46FGFR20.82216645
47PASK0.79451741
48PIK3CG0.74947279
49ADRBK10.73873337
50STK38L0.72344768
51PDK20.72026191
52PAK30.71462812
53PLK30.69932348
54PRKCQ0.67334448
55WNK30.66556949
56MKNK20.66148770
57MAP3K70.65939857
58OXSR10.62968089
59ABL20.62154032
60RPS6KA50.57239269
61CLK10.57113064
62ZAK0.56825724
63PRKACB0.56217270
64PAK60.55887841
65PINK10.55174667
66PHKG20.55029308
67PHKG10.55029308
68TGFBR20.54831442
69GRK50.54711674
70NTRK20.54214812
71MAPK130.53842324
72CCNB10.53827305
73CASK0.53191908
74SIK30.53188833
75MAP3K30.52300308
76FER0.49850587
77EIF2AK10.48229711
78PRKG10.48209396
79EIF2AK20.47454238
80PRKCG0.45241458
81PRKACA0.42863272
82MARK10.42745274
83NLK0.42105730
84MAP3K40.42077667
85KSR10.39997966
86CAMK2D0.39903014
87TNIK0.37350856
88CSNK1D0.37212818
89STK110.35804841
90LMTK20.35480073
91PRKCI0.35184321
92CAMK2A0.34983116
93DAPK30.34661206
94PIM20.31678144
95CDK30.31141102
96CSNK1A10.30853543
97PTK2B0.30537383
98RPS6KA40.30309002
99MAP2K60.29844614
100PRKCA0.29249206

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17490460
2Propanoate metabolism_Homo sapiens_hsa006402.83794789
3Oxidative phosphorylation_Homo sapiens_hsa001902.72033407
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45637472
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40683498
6Phototransduction_Homo sapiens_hsa047442.37973026
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.26196936
8Protein export_Homo sapiens_hsa030602.23362514
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19882146
10Linoleic acid metabolism_Homo sapiens_hsa005912.12334118
11Butanoate metabolism_Homo sapiens_hsa006501.99678118
12Parkinsons disease_Homo sapiens_hsa050121.95841580
13Caffeine metabolism_Homo sapiens_hsa002321.92745095
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91908127
15Selenocompound metabolism_Homo sapiens_hsa004501.86105334
16Nitrogen metabolism_Homo sapiens_hsa009101.83291351
17Collecting duct acid secretion_Homo sapiens_hsa049661.82860552
18Cardiac muscle contraction_Homo sapiens_hsa042601.80814002
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.78828761
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67816492
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67081981
22Basal transcription factors_Homo sapiens_hsa030221.65996977
23RNA polymerase_Homo sapiens_hsa030201.64968525
24Proteasome_Homo sapiens_hsa030501.64060700
25beta-Alanine metabolism_Homo sapiens_hsa004101.53806834
26Ether lipid metabolism_Homo sapiens_hsa005651.51872857
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51264839
28RNA degradation_Homo sapiens_hsa030181.50140587
29Alzheimers disease_Homo sapiens_hsa050101.49616050
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40403958
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37300205
32Huntingtons disease_Homo sapiens_hsa050161.34460259
33Graft-versus-host disease_Homo sapiens_hsa053321.33587223
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31360335
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28971488
36Tryptophan metabolism_Homo sapiens_hsa003801.25689728
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24067915
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21398397
39Nicotine addiction_Homo sapiens_hsa050331.20331465
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18336877
41Fatty acid degradation_Homo sapiens_hsa000711.17174812
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.15413413
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15335339
44Chemical carcinogenesis_Homo sapiens_hsa052041.14499541
45TGF-beta signaling pathway_Homo sapiens_hsa043501.13306889
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11960812
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09891679
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08528474
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06431902
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03211745
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01641702
52Homologous recombination_Homo sapiens_hsa034401.00615180
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99822513
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.98566688
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96123070
56Peroxisome_Homo sapiens_hsa041460.94533803
57Arachidonic acid metabolism_Homo sapiens_hsa005900.91619206
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.87693706
59p53 signaling pathway_Homo sapiens_hsa041150.85834639
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85750705
61Pyruvate metabolism_Homo sapiens_hsa006200.80622057
62Retinol metabolism_Homo sapiens_hsa008300.80412380
63Ribosome_Homo sapiens_hsa030100.78987243
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78573418
65Histidine metabolism_Homo sapiens_hsa003400.78133334
66Glycerolipid metabolism_Homo sapiens_hsa005610.76246721
67Fanconi anemia pathway_Homo sapiens_hsa034600.73903023
68Insulin secretion_Homo sapiens_hsa049110.72734093
69Fat digestion and absorption_Homo sapiens_hsa049750.68789810
70Metabolic pathways_Homo sapiens_hsa011000.68588106
71Sulfur metabolism_Homo sapiens_hsa009200.67480674
72Primary immunodeficiency_Homo sapiens_hsa053400.66589017
73ABC transporters_Homo sapiens_hsa020100.64848515
74Asthma_Homo sapiens_hsa053100.59952969
75GABAergic synapse_Homo sapiens_hsa047270.58513105
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.58506849
77Lysine degradation_Homo sapiens_hsa003100.58254746
78Sulfur relay system_Homo sapiens_hsa041220.57429780
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56941118
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54974498
81Type I diabetes mellitus_Homo sapiens_hsa049400.54256839
82Olfactory transduction_Homo sapiens_hsa047400.53733677
83Pancreatic secretion_Homo sapiens_hsa049720.52866519
84Serotonergic synapse_Homo sapiens_hsa047260.48424488
85Purine metabolism_Homo sapiens_hsa002300.47822418
86Antigen processing and presentation_Homo sapiens_hsa046120.43729662
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43605279
88Mismatch repair_Homo sapiens_hsa034300.43212562
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42158499
90Taste transduction_Homo sapiens_hsa047420.42075541
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40511896
92Fatty acid metabolism_Homo sapiens_hsa012120.40098148
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.38399798
94Regulation of autophagy_Homo sapiens_hsa041400.37205893
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36645312
96Circadian rhythm_Homo sapiens_hsa047100.35319467
97Pyrimidine metabolism_Homo sapiens_hsa002400.34438786
98Non-homologous end-joining_Homo sapiens_hsa034500.32973105
99Arginine and proline metabolism_Homo sapiens_hsa003300.29839212
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.28502738

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