ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.90656521
2	response to pheromone (GO:0019236)	4.10581598
3	sperm motility (GO:0030317)	4.04507401
4	protein polyglutamylation (GO:0018095)	3.95999970
5	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.94039330
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.90417270
7	cellular ketone body metabolic process (GO:0046950)	3.87662554
8	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.86239514
9	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.86239514
10	regulation of translation, ncRNA-mediated (GO:0045974)	3.86239514
11	epithelial cilium movement (GO:0003351)	3.80047008
12	acrosome reaction (GO:0007340)	3.75080752
13	regulation of cilium movement (GO:0003352)	3.71126421
14	ketone body metabolic process (GO:1902224)	3.52306337
15	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.49625852
16	L-fucose catabolic process (GO:0042355)	3.49378645
17	fucose catabolic process (GO:0019317)	3.49378645
18	L-fucose metabolic process (GO:0042354)	3.49378645
19	indolalkylamine metabolic process (GO:0006586)	3.45834779
20	nonmotile primary cilium assembly (GO:0035058)	3.44984906
21	neural tube formation (GO:0001841)	3.43923918
22	indole-containing compound catabolic process (GO:0042436)	3.41478636
23	indolalkylamine catabolic process (GO:0046218)	3.41478636
24	tryptophan catabolic process (GO:0006569)	3.41478636
25	cilium or flagellum-dependent cell motility (GO:0001539)	3.37875093
26	cilium movement (GO:0003341)	3.36290753
27	establishment of protein localization to Golgi (GO:0072600)	3.31502199
28	detection of light stimulus involved in sensory perception (GO:0050962)	3.27445679
29	detection of light stimulus involved in visual perception (GO:0050908)	3.27445679
30	reflex (GO:0060004)	3.19490069
31	gamma-aminobutyric acid transport (GO:0015812)	3.16769833
32	protein localization to cilium (GO:0061512)	3.15825107
33	primary amino compound metabolic process (GO:1901160)	3.14524165
34	multicellular organism reproduction (GO:0032504)	3.10386705
35	neuronal action potential (GO:0019228)	3.09122387
36	synaptic transmission, cholinergic (GO:0007271)	3.08695419
37	piRNA metabolic process (GO:0034587)	3.05919448
38	transmission of nerve impulse (GO:0019226)	2.96799830
39	cilium organization (GO:0044782)	2.96465655
40	regulation of action potential (GO:0098900)	2.96022961
41	kynurenine metabolic process (GO:0070189)	2.95565538
42	axoneme assembly (GO:0035082)	2.95381351
43	membrane depolarization during action potential (GO:0086010)	2.94222955
44	cilium assembly (GO:0042384)	2.93681768
45	behavioral response to ethanol (GO:0048149)	2.90065936
46	calcium ion-dependent exocytosis (GO:0017156)	2.89655150
47	serotonin metabolic process (GO:0042428)	2.89319144
48	regulation of sarcomere organization (GO:0060297)	2.86545598
49	centriole replication (GO:0007099)	2.86194145
50	tryptophan metabolic process (GO:0006568)	2.86078673
51	indole-containing compound metabolic process (GO:0042430)	2.84572687
52	protein targeting to Golgi (GO:0000042)	2.83220695
53	cAMP catabolic process (GO:0006198)	2.82838452
54	postsynaptic membrane organization (GO:0001941)	2.82121616
55	single strand break repair (GO:0000012)	2.81438324
56	spinal cord motor neuron differentiation (GO:0021522)	2.80008021
57	spermatid development (GO:0007286)	2.78551258
58	axonemal dynein complex assembly (GO:0070286)	2.78369910
59	positive regulation of action potential (GO:0045760)	2.78323731
60	intraciliary transport (GO:0042073)	2.78158919
61	neuromuscular synaptic transmission (GO:0007274)	2.74662773
62	negative regulation of telomere maintenance (GO:0032205)	2.72659700
63	microtubule depolymerization (GO:0007019)	2.72449860
64	regulation of microtubule-based movement (GO:0060632)	2.71152585
65	regulation of telomere maintenance (GO:0032204)	2.68444693
66	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.67780663
67	NADH dehydrogenase complex assembly (GO:0010257)	2.67780663
68	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.67780663
69	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.66338322
70	alanine transport (GO:0032328)	2.61110578
71	DNA methylation involved in gamete generation (GO:0043046)	2.59776484
72	cilium morphogenesis (GO:0060271)	2.59423805
73	protein complex biogenesis (GO:0070271)	2.59191168
74	pyrimidine nucleobase catabolic process (GO:0006208)	2.58668571
75	protein localization to synapse (GO:0035418)	2.57131960
76	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.56627339
77	protein localization to Golgi apparatus (GO:0034067)	2.56451653
78	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55530400
79	cyclic nucleotide catabolic process (GO:0009214)	2.54946087
80	peristalsis (GO:0030432)	2.54813456
81	glutamate receptor signaling pathway (GO:0007215)	2.54795926
82	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.52241529
83	nephron tubule morphogenesis (GO:0072078)	2.51694625
84	nephron epithelium morphogenesis (GO:0072088)	2.51694625
85	signal peptide processing (GO:0006465)	2.51604170
86	microtubule polymerization or depolymerization (GO:0031109)	2.49061958
87	dendritic spine morphogenesis (GO:0060997)	2.48998891
88	fusion of sperm to egg plasma membrane (GO:0007342)	2.48725409
89	cornea development in camera-type eye (GO:0061303)	2.48483929
90	photoreceptor cell maintenance (GO:0045494)	2.47462869
91	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.47366715
92	DNA deamination (GO:0045006)	2.47015261
93	synaptic transmission, glutamatergic (GO:0035249)	2.46548132
94	oxidative demethylation (GO:0070989)	2.45839545
95	RNA destabilization (GO:0050779)	2.43090552
96	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.41119262
97	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.40785434
98	regulation of female gonad development (GO:2000194)	2.40520410
99	cellular biogenic amine catabolic process (GO:0042402)	2.40472834
100	amine catabolic process (GO:0009310)	2.40472834

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.32257623
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.63516394
3	VDR_22108803_ChIP-Seq_LS180_Human	3.18489129
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.97206609
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.95273303
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.58380883
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.46366825
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44020420
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.36905639
10	FUS_26573619_Chip-Seq_HEK293_Human	2.20253460
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.16675375
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.08646214
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.05142677
14	P300_19829295_ChIP-Seq_ESCs_Human	1.95971924
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.90386180
16	REST_21632747_ChIP-Seq_MESCs_Mouse	1.86204492
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.82384171
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77507940
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.77507940
20	DROSHA_22980978_ChIP-Seq_HELA_Human	1.74495106
21	EWS_26573619_Chip-Seq_HEK293_Human	1.70960164
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68818030
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66182692
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.65397194
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62345129
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62315536
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.60657103
28	STAT3_23295773_ChIP-Seq_U87_Human	1.60346276
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58880844
30	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.58753574
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57945940
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57254806
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.56890899
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56890899
35	AR_25329375_ChIP-Seq_VCAP_Human	1.55529266
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.52821393
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.51136477
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.50904938
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.50236413
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47459681
41	TCF4_23295773_ChIP-Seq_U87_Human	1.45867032
42	RNF2_27304074_Chip-Seq_NSC_Mouse	1.45312466
43	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43850121
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43514817
45	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.42078719
46	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.40951242
47	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.39319088
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38525576
49	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.37787845
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.35037485
51	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.34587534
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.33342928
53	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.31823950
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31038168
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29274155
56	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27578109
57	TP53_22573176_ChIP-Seq_HFKS_Human	1.26875732
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26329793
59	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26329793
60	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25561500
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.23547004
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23276956
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21759794
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.20895998
65	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20177973
66	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.19787701
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19722805
68	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.19169254
69	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.19088004
70	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.18809927
71	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15771588
72	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14320873
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13877201
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13877201
75	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13096556
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12840387
77	NCOR_22424771_ChIP-Seq_293T_Human	1.09184622
78	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.07250150
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07121685
80	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.05934146
81	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05567819
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05384696
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05311222
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03142842
85	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.02170047
86	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.02146816
87	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.00675840
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00602723
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.00542372
90	ERA_21632823_ChIP-Seq_H3396_Human	1.00022690
91	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97963763
92	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97940407
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.96353370
94	KDM2B_26808549_Chip-Seq_REH_Human	0.96320937
95	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.95684995
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.95249405
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94442409
98	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94277804
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.94273468
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94204850

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	2.70738045
2	MP0000569_abnormal_digit_pigmentation	2.57869982
3	MP0001968_abnormal_touch/_nociception	2.50219297
4	MP0002102_abnormal_ear_morphology	2.39541074
5	MP0003880_abnormal_central_pattern	2.31870892
6	MP0006292_abnormal_olfactory_placode	2.27894361
7	MP0009046_muscle_twitch	2.24652096
8	MP0003136_yellow_coat_color	2.24633772
9	MP0009745_abnormal_behavioral_response	2.24353483
10	MP0005410_abnormal_fertilization	2.20047319
11	MP0005551_abnormal_eye_electrophysiolog	2.16517562
12	MP0002822_catalepsy	2.07018373
13	MP0003787_abnormal_imprinting	2.05247981
14	MP0005377_hearing/vestibular/ear_phenot	2.04949917
15	MP0003878_abnormal_ear_physiology	2.04949917
16	MP0002638_abnormal_pupillary_reflex	2.00449723
17	MP0003195_calcinosis	1.96277600
18	MP0003646_muscle_fatigue	1.94561039
19	MP0002735_abnormal_chemical_nociception	1.94119707
20	MP0006276_abnormal_autonomic_nervous	1.92244302
21	MP0001486_abnormal_startle_reflex	1.85356978
22	MP0001485_abnormal_pinna_reflex	1.85088658
23	MP0005423_abnormal_somatic_nervous	1.84055793
24	MP0002272_abnormal_nervous_system	1.83786598
25	MP0001501_abnormal_sleep_pattern	1.82487946
26	MP0005646_abnormal_pituitary_gland	1.81004673
27	MP0004885_abnormal_endolymph	1.77145988
28	MP0005645_abnormal_hypothalamus_physiol	1.69433387
29	MP0004142_abnormal_muscle_tone	1.67066384
30	MP0002572_abnormal_emotion/affect_behav	1.64725139
31	MP0000372_irregular_coat_pigmentation	1.60901753
32	MP0001905_abnormal_dopamine_level	1.58237193
33	MP0002557_abnormal_social/conspecific_i	1.56061800
34	MP0002064_seizures	1.55944386
35	MP0003635_abnormal_synaptic_transmissio	1.54805840
36	MP0002837_dystrophic_cardiac_calcinosis	1.54288253
37	MP0002736_abnormal_nociception_after	1.54284924
38	MP0002653_abnormal_ependyma_morphology	1.52802095
39	MP0004133_heterotaxia	1.51264714
40	MP0006072_abnormal_retinal_apoptosis	1.47987145
41	MP0003698_abnormal_male_reproductive	1.46258261
42	MP0005253_abnormal_eye_physiology	1.43890260
43	MP0004145_abnormal_muscle_electrophysio	1.42275423
44	MP0002067_abnormal_sensory_capabilities	1.41612824
45	MP0002733_abnormal_thermal_nociception	1.41533044
46	MP0000631_abnormal_neuroendocrine_gland	1.41334777
47	MP0002938_white_spotting	1.40928480
48	MP0001440_abnormal_grooming_behavior	1.37857180
49	MP0001970_abnormal_pain_threshold	1.37766666
50	MP0008872_abnormal_physiological_respon	1.37478119
51	MP0001188_hyperpigmentation	1.36242951
52	MP0004147_increased_porphyrin_level	1.36196524
53	MP0001986_abnormal_taste_sensitivity	1.35846267
54	MP0010386_abnormal_urinary_bladder	1.32019984
55	MP0005174_abnormal_tail_pigmentation	1.29143612
56	MP0001984_abnormal_olfaction	1.28812643
57	MP0005386_behavior/neurological_phenoty	1.28121468
58	MP0004924_abnormal_behavior	1.28121468
59	MP0002063_abnormal_learning/memory/cond	1.27821919
60	MP0004043_abnormal_pH_regulation	1.22524519
61	MP0003879_abnormal_hair_cell	1.19588727
62	MP0004742_abnormal_vestibular_system	1.18645454
63	MP0002184_abnormal_innervation	1.18588633
64	MP0000026_abnormal_inner_ear	1.17665455
65	MP0001963_abnormal_hearing_physiology	1.17096732
66	MP0003011_delayed_dark_adaptation	1.17022152
67	MP0002734_abnormal_mechanical_nocicepti	1.16031309
68	MP0001929_abnormal_gametogenesis	1.16022105
69	MP0002234_abnormal_pharynx_morphology	1.12604223
70	MP0003121_genomic_imprinting	1.09403254
71	MP0001529_abnormal_vocalization	1.09231987
72	MP0002928_abnormal_bile_duct	1.08835891
73	MP0002163_abnormal_gland_morphology	1.08561228
74	MP0000778_abnormal_nervous_system	1.06934795
75	MP0002876_abnormal_thyroid_physiology	1.03736151
76	MP0002752_abnormal_somatic_nervous	1.03378764
77	MP0003122_maternal_imprinting	1.03257032
78	MP0005379_endocrine/exocrine_gland_phen	0.98106858
79	MP0005084_abnormal_gallbladder_morpholo	0.97939282
80	MP0000955_abnormal_spinal_cord	0.95503131
81	MP0003283_abnormal_digestive_organ	0.92796403
82	MP0003890_abnormal_embryonic-extraembry	0.90566234
83	MP0004859_abnormal_synaptic_plasticity	0.90533368
84	MP0005195_abnormal_posterior_eye	0.90440540
85	MP0002229_neurodegeneration	0.89074120
86	MP0002882_abnormal_neuron_morphology	0.86520507
87	MP0008995_early_reproductive_senescence	0.85558564
88	MP0002160_abnormal_reproductive_system	0.85170707
89	MP0008789_abnormal_olfactory_epithelium	0.85167481
90	MP0002909_abnormal_adrenal_gland	0.85124435
91	MP0005075_abnormal_melanosome_morpholog	0.83938827
92	MP0000230_abnormal_systemic_arterial	0.83161724
93	MP0003119_abnormal_digestive_system	0.82623548
94	MP0002095_abnormal_skin_pigmentation	0.82172142
95	MP0002210_abnormal_sex_determination	0.81266744
96	MP0000427_abnormal_hair_cycle	0.81233048
97	MP0005448_abnormal_energy_balance	0.80491080
98	MP0003718_maternal_effect	0.79671648
99	MP0004085_abnormal_heartbeat	0.78096872
100	MP0005394_taste/olfaction_phenotype	0.78038672

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.19667550
2	Pancreatic cysts (HP:0001737)	4.00823924
3	Progressive cerebellar ataxia (HP:0002073)	3.88014239
4	Nephronophthisis (HP:0000090)	3.77269958
5	Congenital stationary night blindness (HP:0007642)	3.74694621
6	Hyperventilation (HP:0002883)	3.71464288
7	Pancreatic fibrosis (HP:0100732)	3.69673661
8	Molar tooth sign on MRI (HP:0002419)	3.54874442
9	Abnormality of midbrain morphology (HP:0002418)	3.54874442
10	Chronic hepatic failure (HP:0100626)	3.45693904
11	True hermaphroditism (HP:0010459)	3.44254591
12	Abnormality of the renal medulla (HP:0100957)	3.26934519
13	Medial flaring of the eyebrow (HP:0010747)	3.20232803
14	Attenuation of retinal blood vessels (HP:0007843)	2.97357042
15	Gaze-evoked nystagmus (HP:0000640)	2.95740995
16	Abnormality of the renal cortex (HP:0011035)	2.91699591
17	Retinal dysplasia (HP:0007973)	2.89392426
18	Type II lissencephaly (HP:0007260)	2.89285887
19	Polydipsia (HP:0001959)	2.79186397
20	Abnormal drinking behavior (HP:0030082)	2.79186397
21	Bony spicule pigmentary retinopathy (HP:0007737)	2.68705165
22	Febrile seizures (HP:0002373)	2.67045997
23	Gait imbalance (HP:0002141)	2.65833722
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.64482740
25	Cystic liver disease (HP:0006706)	2.62728741
26	Sclerocornea (HP:0000647)	2.59573631
27	Absent/shortened dynein arms (HP:0200106)	2.56211245
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.56211245
29	Tubular atrophy (HP:0000092)	2.54195691
30	Decreased central vision (HP:0007663)	2.54061750
31	Abnormal respiratory epithelium morphology (HP:0012253)	2.51190053
32	Abnormal respiratory motile cilium morphology (HP:0005938)	2.51190053
33	Congenital primary aphakia (HP:0007707)	2.51002608
34	Abolished electroretinogram (ERG) (HP:0000550)	2.48878392
35	Abnormal ciliary motility (HP:0012262)	2.47885237
36	Protruding tongue (HP:0010808)	2.46352544
37	Severe visual impairment (HP:0001141)	2.43377827
38	Inability to walk (HP:0002540)	2.42904401
39	Focal motor seizures (HP:0011153)	2.37711720
40	Lissencephaly (HP:0001339)	2.33956963
41	Genital tract atresia (HP:0001827)	2.32946510
42	Nephrogenic diabetes insipidus (HP:0009806)	2.28441681
43	Vaginal atresia (HP:0000148)	2.26931056
44	Broad-based gait (HP:0002136)	2.21760046
45	Pendular nystagmus (HP:0012043)	2.20809891
46	Hypothermia (HP:0002045)	2.20565167
47	Large for gestational age (HP:0001520)	2.18760196
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.18408916
49	Polyuria (HP:0000103)	2.17670947
50	Epileptic encephalopathy (HP:0200134)	2.16292538
51	Congenital hepatic fibrosis (HP:0002612)	2.06955833
52	Decreased circulating renin level (HP:0003351)	2.06797946
53	Optic nerve hypoplasia (HP:0000609)	2.06050786
54	Dialeptic seizures (HP:0011146)	2.04493644
55	Anencephaly (HP:0002323)	2.03279327
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.02739052
57	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.98443542
58	Cerebellar dysplasia (HP:0007033)	1.98350117
59	Limb dystonia (HP:0002451)	1.98203384
60	Poor coordination (HP:0002370)	1.96490865
61	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.96380212
62	Focal seizures (HP:0007359)	1.95560946
63	Progressive inability to walk (HP:0002505)	1.95385222
64	Abnormality of macular pigmentation (HP:0008002)	1.94886203
65	Abnormality of the pons (HP:0007361)	1.94714456
66	Hypoplasia of the pons (HP:0012110)	1.90304683
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.88150466
68	Atonic seizures (HP:0010819)	1.87963846
69	Tubulointerstitial nephritis (HP:0001970)	1.87781063
70	Bile duct proliferation (HP:0001408)	1.86790290
71	Abnormal biliary tract physiology (HP:0012439)	1.86790290
72	Postaxial foot polydactyly (HP:0001830)	1.85854848
73	Congenital sensorineural hearing impairment (HP:0008527)	1.85611466
74	Abnormality of the labia minora (HP:0012880)	1.83957449
75	Increased corneal curvature (HP:0100692)	1.83002318
76	Keratoconus (HP:0000563)	1.83002318
77	Hemiparesis (HP:0001269)	1.82860756
78	Pachygyria (HP:0001302)	1.82860387
79	Abnormal urine output (HP:0012590)	1.82689252
80	Renal cortical cysts (HP:0000803)	1.82239786
81	Absence seizures (HP:0002121)	1.82231310
82	Concave nail (HP:0001598)	1.79825318
83	Oligodactyly (hands) (HP:0001180)	1.79684734
84	Male pseudohermaphroditism (HP:0000037)	1.78203174
85	Patellar aplasia (HP:0006443)	1.77245745
86	Intestinal atresia (HP:0011100)	1.75196373
87	Drooling (HP:0002307)	1.72729556
88	Abnormality of the pubic bones (HP:0003172)	1.70949863
89	Clumsiness (HP:0002312)	1.69926996
90	Aplasia/Hypoplasia of the patella (HP:0006498)	1.68922765
91	Postaxial hand polydactyly (HP:0001162)	1.68868305
92	Absent speech (HP:0001344)	1.68811182
93	Occipital encephalocele (HP:0002085)	1.68066880
94	Anophthalmia (HP:0000528)	1.67264129
95	Furrowed tongue (HP:0000221)	1.67153033
96	Retinitis pigmentosa (HP:0000510)	1.66399477
97	Mitochondrial inheritance (HP:0001427)	1.65715216
98	Stomach cancer (HP:0012126)	1.65154513
99	Agitation (HP:0000713)	1.63627777
100	Abnormality of renal excretion (HP:0011036)	1.62715443

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.69442355
2	BMPR1B	3.12047625
3	ADRBK2	3.06340013
4	INSRR	2.62327502
5	MAP4K2	2.55680258
6	WNK3	2.45926768
7	CASK	2.36716108
8	ACVR1B	2.36591772
9	WNK4	2.33935626
10	PNCK	2.27024279
11	PINK1	2.19266987
12	MAPK13	2.04590685
13	TLK1	1.98625590
14	GRK1	1.98558811
15	MAP3K4	1.83482183
16	NTRK3	1.82710231
17	TAOK3	1.77787138
18	SIK2	1.72774873
19	STK39	1.64794703
20	PLK4	1.62082914
21	DAPK2	1.57483411
22	MARK1	1.53554138
23	AKT3	1.52225841
24	TNIK	1.49212963
25	MAPK15	1.46954905
26	ZAK	1.41793634
27	MAP2K7	1.27363511
28	OXSR1	1.26176619
29	CAMKK2	1.25322214
30	NUAK1	1.23252922
31	PRKCG	1.22894162
32	STK16	1.18955633
33	MKNK2	1.15239380
34	ADRBK1	1.12999254
35	CAMK1G	1.09539850
36	PLK2	1.07864270
37	PRKCE	1.02701718
38	TRIM28	1.02393927
39	DYRK2	0.99283799
40	PAK3	0.97674180
41	PASK	0.93891936
42	TGFBR1	0.91755069
43	FGFR2	0.88792357
44	WNK1	0.87267711
45	CAMK1	0.85263211
46	NTRK2	0.84838117
47	CDK3	0.80780280
48	TXK	0.78044530
49	EPHA4	0.76897920
50	PIK3CA	0.74172135
51	PTK2B	0.71811801
52	STK38L	0.71632543
53	CAMKK1	0.69672880
54	NEK2	0.69612323
55	PKN1	0.69115216
56	TEC	0.68674337
57	BRD4	0.68627679
58	CAMK1D	0.68332099
59	RPS6KA5	0.62475796
60	CAMK2A	0.60364619
61	OBSCN	0.59492517
62	MAP2K6	0.58808623
63	PHKG2	0.57074802
64	PHKG1	0.57074802
65	DYRK1A	0.55790003
66	TNK2	0.55064129
67	SGK223	0.53258368
68	SGK494	0.53258368
69	PRKACA	0.51554964
70	CSNK1A1	0.50542041
71	PRKCQ	0.50412033
72	PRKG1	0.49833511
73	VRK1	0.49330097
74	PIK3CG	0.49159773
75	CSNK1G2	0.48561097
76	SGK2	0.48362451
77	CAMK4	0.47880971
78	MINK1	0.44916684
79	MUSK	0.42976692
80	NME1	0.42240276
81	ERBB2	0.41400993
82	MKNK1	0.40781813
83	SGK1	0.40773337
84	STK38	0.39046434
85	PRKCH	0.37976837
86	TIE1	0.37123319
87	KIT	0.37017557
88	PRKAA1	0.35918656
89	ERBB3	0.35667844
90	ATR	0.35079487
91	PRKCZ	0.34966549
92	PRKCA	0.33654556
93	CSNK1G1	0.33319233
94	PRKACB	0.32403138
95	CSNK1D	0.32056440
96	BCR	0.31880526
97	PRKCB	0.30079306
98	CHUK	0.29858948
99	STK3	0.29222053
100	WEE1	0.29098085

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.14511944
2	Phototransduction_Homo sapiens_hsa04744	2.82859758
3	Butanoate metabolism_Homo sapiens_hsa00650	2.69920322
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.63094520
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.47876343
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.28826570
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.27876267
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.26847098
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.20975438
10	Morphine addiction_Homo sapiens_hsa05032	2.16406858
11	Taste transduction_Homo sapiens_hsa04742	2.11053263
12	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.96414473
13	Oxidative phosphorylation_Homo sapiens_hsa00190	1.93572526
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.90538512
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.89874128
16	Olfactory transduction_Homo sapiens_hsa04740	1.89838453
17	GABAergic synapse_Homo sapiens_hsa04727	1.81474778
18	Circadian entrainment_Homo sapiens_hsa04713	1.73243600
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.72752822
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.68330504
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.67485745
22	Insulin secretion_Homo sapiens_hsa04911	1.60905998
23	Glutamatergic synapse_Homo sapiens_hsa04724	1.58113721
24	Protein export_Homo sapiens_hsa03060	1.49211286
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.46342966
26	Serotonergic synapse_Homo sapiens_hsa04726	1.41958246
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.41620013
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37834907
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.37667443
30	Parkinsons disease_Homo sapiens_hsa05012	1.37593890
31	Homologous recombination_Homo sapiens_hsa03440	1.33215052
32	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.27673614
33	ABC transporters_Homo sapiens_hsa02010	1.24901270
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24120644
35	Regulation of autophagy_Homo sapiens_hsa04140	1.23679247
36	Propanoate metabolism_Homo sapiens_hsa00640	1.18994385
37	Cocaine addiction_Homo sapiens_hsa05030	1.18675924
38	RNA polymerase_Homo sapiens_hsa03020	1.18206519
39	Basal transcription factors_Homo sapiens_hsa03022	1.18104509
40	Huntingtons disease_Homo sapiens_hsa05016	1.17029157
41	Calcium signaling pathway_Homo sapiens_hsa04020	1.11340026
42	Dopaminergic synapse_Homo sapiens_hsa04728	1.09178842
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05360822
44	Cholinergic synapse_Homo sapiens_hsa04725	1.01603014
45	Retinol metabolism_Homo sapiens_hsa00830	1.00781084
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.00693161
47	Peroxisome_Homo sapiens_hsa04146	0.99750639
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.95244452
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94623961
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93295214
51	Salivary secretion_Homo sapiens_hsa04970	0.92704520
52	Amphetamine addiction_Homo sapiens_hsa05031	0.91943726
53	Alzheimers disease_Homo sapiens_hsa05010	0.89953272
54	Caffeine metabolism_Homo sapiens_hsa00232	0.89256354
55	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.88648541
56	RNA degradation_Homo sapiens_hsa03018	0.85898153
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85196021
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84438793
59	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.83987450
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.81744660
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.80563953
62	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.80189624
63	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.77250793
64	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.76844726
65	Gastric acid secretion_Homo sapiens_hsa04971	0.75877868
66	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.73599767
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.71831867
68	Purine metabolism_Homo sapiens_hsa00230	0.70993706
69	Sulfur relay system_Homo sapiens_hsa04122	0.69224349
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64256732
71	Circadian rhythm_Homo sapiens_hsa04710	0.63071260
72	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.63065522
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.61025859
74	Long-term depression_Homo sapiens_hsa04730	0.59686569
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59334500
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.56377553
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55849562
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.55411359
79	Renin secretion_Homo sapiens_hsa04924	0.54537544
80	Type II diabetes mellitus_Homo sapiens_hsa04930	0.52591332
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52386647
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52165171
83	Ribosome_Homo sapiens_hsa03010	0.51070286
84	Metabolic pathways_Homo sapiens_hsa01100	0.50270194
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48958170
86	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.44912592
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42970630
88	Fatty acid degradation_Homo sapiens_hsa00071	0.42396254
89	Lysine degradation_Homo sapiens_hsa00310	0.40090093
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39682755
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.36185264
92	One carbon pool by folate_Homo sapiens_hsa00670	0.35812685
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.35649943
94	Type I diabetes mellitus_Homo sapiens_hsa04940	0.35262770
95	Pancreatic secretion_Homo sapiens_hsa04972	0.34625790
96	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.32785040
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.32106773
98	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29553672
99	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.27388819
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.26457811

SEPT7P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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