SEPT7P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cytosolic calcium ion concentration (GO:0051481)5.75444221
2piRNA metabolic process (GO:0034587)4.78465765
3protein polyglutamylation (GO:0018095)4.76782153
4positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.75269372
5behavioral response to nicotine (GO:0035095)4.52674770
6positive regulation of natural killer cell mediated immunity (GO:0002717)4.42941575
7DNA deamination (GO:0045006)4.32160607
8positive regulation of natural killer cell differentiation (GO:0032825)4.31847059
9regulation of action potential (GO:0098900)4.04438420
10behavioral response to ethanol (GO:0048149)3.76116699
11negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.73218748
12regulation of sarcomere organization (GO:0060297)3.71872622
13L-fucose catabolic process (GO:0042355)3.71336515
14fucose catabolic process (GO:0019317)3.71336515
15L-fucose metabolic process (GO:0042354)3.71336515
16ribonucleoprotein complex disassembly (GO:0032988)3.71319079
17protein neddylation (GO:0045116)3.68072061
18positive regulation of interleukin-17 production (GO:0032740)3.65685571
19adult feeding behavior (GO:0008343)3.53974657
20cellular ketone body metabolic process (GO:0046950)3.52988601
21negative regulation of cAMP-mediated signaling (GO:0043951)3.52843887
22positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.43222781
23cytidine metabolic process (GO:0046087)3.37127252
24cytidine catabolic process (GO:0006216)3.37127252
25cytidine deamination (GO:0009972)3.37127252
26cellular response to interleukin-15 (GO:0071350)3.33894563
27negative regulation of nitric-oxide synthase activity (GO:0051001)3.29036842
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.28562021
29regulation of natural killer cell mediated immunity (GO:0002715)3.28562021
30ketone body metabolic process (GO:1902224)3.27018656
31organelle disassembly (GO:1903008)3.26172386
32positive regulation of cAMP-mediated signaling (GO:0043950)3.11403451
33regulation of protein glycosylation (GO:0060049)3.09266870
34negative regulation of protein localization to cell surface (GO:2000009)3.07734342
35regulation of hexokinase activity (GO:1903299)3.07084912
36regulation of glucokinase activity (GO:0033131)3.07084912
37inner mitochondrial membrane organization (GO:0007007)3.04976889
38dopamine transport (GO:0015872)3.04146651
39pyrimidine ribonucleoside catabolic process (GO:0046133)3.03692966
40positive regulation of cell killing (GO:0031343)3.03334714
41regulation of acrosome reaction (GO:0060046)2.99291584
42viral mRNA export from host cell nucleus (GO:0046784)2.98931109
43pyrimidine nucleobase catabolic process (GO:0006208)2.97862688
44nucleobase catabolic process (GO:0046113)2.97022140
45kidney morphogenesis (GO:0060993)2.96896359
46axoneme assembly (GO:0035082)2.96164306
47sphingosine metabolic process (GO:0006670)2.96032835
48acrosome assembly (GO:0001675)2.95632105
49regulation of leukocyte mediated cytotoxicity (GO:0001910)2.95266020
50retinal cone cell development (GO:0046549)2.92585024
51sphingoid metabolic process (GO:0046519)2.85028465
52diol metabolic process (GO:0034311)2.81227930
53regulation of natural killer cell differentiation (GO:0032823)2.77598448
54lymph node development (GO:0048535)2.74958960
55negative regulation of nitric oxide biosynthetic process (GO:0045019)2.74265774
56regulation of skeletal muscle contraction (GO:0014819)2.73314144
57positive regulation of fatty acid transport (GO:2000193)2.73226664
58response to interleukin-15 (GO:0070672)2.73103061
59somite rostral/caudal axis specification (GO:0032525)2.71985264
60activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.71604251
61positive regulation of cardiac muscle cell differentiation (GO:2000727)2.70560365
62neuronal action potential (GO:0019228)2.67847794
63regulation of cell killing (GO:0031341)2.66674859
64negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.65466560
65negative regulation of T-helper cell differentiation (GO:0045623)2.65466560
66phosphorelay signal transduction system (GO:0000160)2.57358234
67negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.57289519
68positive regulation of meiosis (GO:0045836)2.55758347
69regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.55539712
70regulation of cytokine production involved in inflammatory response (GO:1900015)2.54984120
71opioid receptor signaling pathway (GO:0038003)2.54146969
72postreplication repair (GO:0006301)2.53343452
73activated T cell proliferation (GO:0050798)2.51098852
74regulation of memory T cell differentiation (GO:0043380)2.48398347
75transmission of nerve impulse (GO:0019226)2.48306101
76regulation of T cell chemotaxis (GO:0010819)2.48290161
77positive regulation of T cell chemotaxis (GO:0010820)2.48290161
78primary amino compound metabolic process (GO:1901160)2.46454555
79thyroid hormone metabolic process (GO:0042403)2.45681111
80protein-cofactor linkage (GO:0018065)2.45496671
81replication fork processing (GO:0031297)2.45328281
82regulation of lymphocyte chemotaxis (GO:1901623)2.44382474
83oxidative demethylation (GO:0070989)2.43826541
84regulation of membrane repolarization (GO:0060306)2.42392204
85positive regulation of icosanoid secretion (GO:0032305)2.42323786
86regulation of isotype switching to IgG isotypes (GO:0048302)2.40592021
87regulation of rhodopsin mediated signaling pathway (GO:0022400)2.39783012
88termination of RNA polymerase III transcription (GO:0006386)2.39686672
89transcription elongation from RNA polymerase III promoter (GO:0006385)2.39686672
90negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.39390826
91nucleotide transmembrane transport (GO:1901679)2.38212527
92DNA methylation involved in gamete generation (GO:0043046)2.38056047
93negative regulation of adaptive immune response (GO:0002820)2.37878800
94regulation of female receptivity (GO:0045924)2.37576894
95regulation of neurotransmitter uptake (GO:0051580)2.37144715
96positive regulation of T-helper 1 type immune response (GO:0002827)2.36846948
97positive regulation of meiotic cell cycle (GO:0051446)2.35608736
98adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.34370345
99ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.33409880
100regulation of chronic inflammatory response (GO:0002676)2.32044117

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.92984376
2ZNF274_21170338_ChIP-Seq_K562_Hela3.33925308
3EZH2_22144423_ChIP-Seq_EOC_Human3.23851236
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.21060607
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.90912849
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.88466618
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62072314
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.42335071
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.31154616
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19581622
11IGF1R_20145208_ChIP-Seq_DFB_Human2.18575896
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12887780
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07857665
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05161767
15P300_19829295_ChIP-Seq_ESCs_Human1.91346262
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.89611053
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87834286
18GBX2_23144817_ChIP-Seq_PC3_Human1.87605666
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87575897
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.83830716
21FUS_26573619_Chip-Seq_HEK293_Human1.80956738
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78695214
23TAF15_26573619_Chip-Seq_HEK293_Human1.76677040
24EWS_26573619_Chip-Seq_HEK293_Human1.75490499
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72269488
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.61175136
27SMAD4_21799915_ChIP-Seq_A2780_Human1.58780741
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57079051
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54716625
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54716625
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54601130
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52569422
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.52300872
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50829024
35BCAT_22108803_ChIP-Seq_LS180_Human1.50777909
36ER_23166858_ChIP-Seq_MCF-7_Human1.49822963
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48537076
38STAT3_23295773_ChIP-Seq_U87_Human1.47999459
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47947395
40PRDM14_20953172_ChIP-Seq_ESCs_Human1.45601082
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.44860646
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41418147
43IRF1_19129219_ChIP-ChIP_H3396_Human1.39771321
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39130378
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37908050
46NANOG_19829295_ChIP-Seq_ESCs_Human1.37397570
47SOX2_19829295_ChIP-Seq_ESCs_Human1.37397570
48TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.37278433
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.37210422
50TP53_22573176_ChIP-Seq_HFKS_Human1.36298361
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.36089005
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34984250
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33955708
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.33736865
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31858042
56TCF4_22108803_ChIP-Seq_LS180_Human1.30830510
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29486062
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29186760
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27729622
60BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26345917
61HTT_18923047_ChIP-ChIP_STHdh_Human1.26017248
62TCF4_23295773_ChIP-Seq_U87_Human1.25551738
63REST_21632747_ChIP-Seq_MESCs_Mouse1.25306087
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24852664
65CBP_20019798_ChIP-Seq_JUKART_Human1.24852664
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23392302
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21040154
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.19593289
69FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19593289
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18844390
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18755166
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.17895525
73AR_25329375_ChIP-Seq_VCAP_Human1.17791511
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17675945
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17646553
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16768417
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.16649983
78P53_22387025_ChIP-Seq_ESCs_Mouse1.14950763
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14280354
80NCOR_22424771_ChIP-Seq_293T_Human1.11768028
81FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08677223
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08443051
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.08231013
84RUNX2_22187159_ChIP-Seq_PCA_Human1.07865659
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.04478117
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.02519272
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.02388918
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00047712
89SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99847398
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.98759598
91SMAD4_21741376_ChIP-Seq_EPCs_Human0.98241111
92ELK1_19687146_ChIP-ChIP_HELA_Human0.97220104
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96615780
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96432703
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96269463
96ETV1_20927104_ChIP-Seq_GIST48_Human0.95493569
97RNF2_27304074_Chip-Seq_NSC_Mouse0.93869304
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93654704
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93370198
100SOX2_18555785_Chip-Seq_ESCs_Mouse0.92998251

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.46397191
2MP0001968_abnormal_touch/_nociception3.09046986
3MP0005646_abnormal_pituitary_gland3.04896956
4MP0003646_muscle_fatigue2.89640288
5MP0003950_abnormal_plasma_membrane2.89520035
6MP0005075_abnormal_melanosome_morpholog2.78974494
7MP0002102_abnormal_ear_morphology2.62667158
8MP0008872_abnormal_physiological_respon2.59791703
9MP0000569_abnormal_digit_pigmentation2.50951955
10MP0005645_abnormal_hypothalamus_physiol2.37283430
11MP0002876_abnormal_thyroid_physiology2.34303763
12MP0004142_abnormal_muscle_tone2.27439601
13MP0001501_abnormal_sleep_pattern2.23782556
14MP0004742_abnormal_vestibular_system2.22692788
15MP0009745_abnormal_behavioral_response2.12790783
16MP0009780_abnormal_chondrocyte_physiolo2.12240901
17MP0004145_abnormal_muscle_electrophysio2.03859095
18MP0006292_abnormal_olfactory_placode2.00431759
19MP0008877_abnormal_DNA_methylation2.00264729
20MP0000749_muscle_degeneration1.98664968
21MP0002138_abnormal_hepatobiliary_system1.98480272
22MP0009046_muscle_twitch1.95428824
23MP0004270_analgesia1.94336729
24MP0002163_abnormal_gland_morphology1.89983577
25MP0003880_abnormal_central_pattern1.87752848
26MP0003787_abnormal_imprinting1.86999212
27MP0003045_fibrosis1.84654213
28MP0005551_abnormal_eye_electrophysiolog1.82497201
29MP0002909_abnormal_adrenal_gland1.78446414
30MP0002272_abnormal_nervous_system1.75789384
31MP0005360_urolithiasis1.72923619
32MP0003136_yellow_coat_color1.72705346
33MP0003195_calcinosis1.71018380
34MP0001486_abnormal_startle_reflex1.70531096
35MP0002736_abnormal_nociception_after1.57854337
36MP0002638_abnormal_pupillary_reflex1.51308166
37MP0008875_abnormal_xenobiotic_pharmacok1.51016501
38MP0002733_abnormal_thermal_nociception1.50184592
39MP0005379_endocrine/exocrine_gland_phen1.46658881
40MP0000372_irregular_coat_pigmentation1.44141463
41MP0000015_abnormal_ear_pigmentation1.43856670
42MP0003635_abnormal_synaptic_transmissio1.40935277
43MP0001485_abnormal_pinna_reflex1.39763341
44MP0002064_seizures1.37470853
45MP0005310_abnormal_salivary_gland1.32658195
46MP0001970_abnormal_pain_threshold1.28069507
47MP0003011_delayed_dark_adaptation1.26727645
48MP0002572_abnormal_emotion/affect_behav1.26420882
49MP0002067_abnormal_sensory_capabilities1.25879201
50MP0002734_abnormal_mechanical_nocicepti1.17918276
51MP0002693_abnormal_pancreas_physiology1.17138687
52MP0001502_abnormal_circadian_rhythm1.13417754
53MP0002234_abnormal_pharynx_morphology1.10529451
54MP0001790_abnormal_immune_system1.08305005
55MP0005387_immune_system_phenotype1.08305005
56MP0002557_abnormal_social/conspecific_i1.05808580
57MP0001919_abnormal_reproductive_system1.04618462
58MP0000631_abnormal_neuroendocrine_gland1.02122843
59MP0001348_abnormal_lacrimal_gland1.01127009
60MP0005671_abnormal_response_to0.99532660
61MP0001529_abnormal_vocalization0.97918049
62MP0002095_abnormal_skin_pigmentation0.97543546
63MP0001905_abnormal_dopamine_level0.97276572
64MP0005389_reproductive_system_phenotype0.96939782
65MP0005410_abnormal_fertilization0.96425761
66MP0002277_abnormal_respiratory_mucosa0.96300764
67MP0004043_abnormal_pH_regulation0.96141993
68MP0004381_abnormal_hair_follicle0.95239852
69MP0001986_abnormal_taste_sensitivity0.93660637
70MP0003890_abnormal_embryonic-extraembry0.92161375
71MP0005167_abnormal_blood-brain_barrier0.91782690
72MP0001440_abnormal_grooming_behavior0.91137766
73MP0006276_abnormal_autonomic_nervous0.87339385
74MP0002063_abnormal_learning/memory/cond0.86936928
75MP0003252_abnormal_bile_duct0.85588223
76MP0001873_stomach_inflammation0.85533493
77MP0006072_abnormal_retinal_apoptosis0.85325790
78MP0002168_other_aberrant_phenotype0.83953542
79MP0001664_abnormal_digestion0.83829729
80MP0006035_abnormal_mitochondrial_morpho0.83778109
81MP0005253_abnormal_eye_physiology0.83269350
82MP0010386_abnormal_urinary_bladder0.82834610
83MP0002229_neurodegeneration0.82452755
84MP0002751_abnormal_autonomic_nervous0.82432873
85MP0004885_abnormal_endolymph0.81913593
86MP0004924_abnormal_behavior0.80804754
87MP0005386_behavior/neurological_phenoty0.80804754
88MP0002938_white_spotting0.78647392
89MP0000013_abnormal_adipose_tissue0.78375226
90MP0004484_altered_response_of0.77677048
91MP0003633_abnormal_nervous_system0.77281462
92MP0000230_abnormal_systemic_arterial0.77121344
93MP0002184_abnormal_innervation0.76391930
94MP0002822_catalepsy0.74887218
95MP0005085_abnormal_gallbladder_physiolo0.74716604
96MP0005195_abnormal_posterior_eye0.73482259
97MP0000778_abnormal_nervous_system0.72769142
98MP0005174_abnormal_tail_pigmentation0.71299818
99MP0010329_abnormal_lipoprotein_level0.69323625
100MP0005332_abnormal_amino_acid0.68389731

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)3.94653267
2Thyroid-stimulating hormone excess (HP:0002925)3.69010543
3Abnormality of the renal cortex (HP:0011035)3.68308154
4Gaze-evoked nystagmus (HP:0000640)3.61737399
5Depressed nasal tip (HP:0000437)3.61571861
6Intestinal atresia (HP:0011100)3.57165076
7Type II lissencephaly (HP:0007260)3.45896514
8Pancreatic cysts (HP:0001737)3.36392024
9Tubular atrophy (HP:0000092)3.35973381
10Pancreatic fibrosis (HP:0100732)3.19124349
11Medial flaring of the eyebrow (HP:0010747)3.11519576
12Volvulus (HP:0002580)3.01768977
13Focal motor seizures (HP:0011153)2.96995609
14Increased corneal curvature (HP:0100692)2.92634824
15Keratoconus (HP:0000563)2.92634824
16Broad alveolar ridges (HP:0000187)2.81295153
17Sclerocornea (HP:0000647)2.81201949
18Lissencephaly (HP:0001339)2.77416519
19Pancreatic islet-cell hyperplasia (HP:0004510)2.76960380
20Congenital stationary night blindness (HP:0007642)2.72112934
21Renal Fanconi syndrome (HP:0001994)2.71194032
22Exercise-induced myalgia (HP:0003738)2.70783494
23Calf muscle hypertrophy (HP:0008981)2.70065668
24Chronic diarrhea (HP:0002028)2.69988939
25Acute necrotizing encephalopathy (HP:0006965)2.66045175
26Focal seizures (HP:0007359)2.62266707
27Progressive inability to walk (HP:0002505)2.61470929
28Inability to walk (HP:0002540)2.60003870
29Neonatal hypoglycemia (HP:0001998)2.59915939
30Molar tooth sign on MRI (HP:0002419)2.57786655
31Abnormality of midbrain morphology (HP:0002418)2.57786655
32Chorioretinal atrophy (HP:0000533)2.56341196
33Pendular nystagmus (HP:0012043)2.52468928
34Cerebellar dysplasia (HP:0007033)2.50161707
35Acute encephalopathy (HP:0006846)2.49918588
36Type 2 muscle fiber atrophy (HP:0003554)2.42611702
37Genetic anticipation (HP:0003743)2.41730623
38Progressive macrocephaly (HP:0004481)2.41348960
39Attenuation of retinal blood vessels (HP:0007843)2.40715274
40Nephronophthisis (HP:0000090)2.39518082
413-Methylglutaconic aciduria (HP:0003535)2.39088717
42Toxemia of pregnancy (HP:0100603)2.35713979
43Hypoproteinemia (HP:0003075)2.34548240
44Median cleft lip (HP:0000161)2.34085552
45Mitochondrial inheritance (HP:0001427)2.34075015
46Abnormality of the labia minora (HP:0012880)2.33424439
47Muscle hypertrophy of the lower extremities (HP:0008968)2.30433853
48Increased hepatocellular lipid droplets (HP:0006565)2.29798762
49Gastrointestinal atresia (HP:0002589)2.25674931
50Methylmalonic acidemia (HP:0002912)2.25195107
51Mesangial abnormality (HP:0001966)2.23747206
52Anhidrosis (HP:0000970)2.23356691
53Increased CSF lactate (HP:0002490)2.22887725
54Lipid accumulation in hepatocytes (HP:0006561)2.20572635
55Abolished electroretinogram (ERG) (HP:0000550)2.19667625
56True hermaphroditism (HP:0010459)2.19538415
57Progressive cerebellar ataxia (HP:0002073)2.15313384
58Pachygyria (HP:0001302)2.14458166
59Abnormal mitochondria in muscle tissue (HP:0008316)2.12204356
60Abnormality of the renal medulla (HP:0100957)2.11547835
61Prolonged QT interval (HP:0001657)2.06986727
62Optic nerve hypoplasia (HP:0000609)2.06511256
63Disproportionate short-trunk short stature (HP:0003521)1.98931058
64Abnormality of renal resorption (HP:0011038)1.97587139
65Palpebral edema (HP:0100540)1.93492761
66Gait imbalance (HP:0002141)1.93203078
67Muscle stiffness (HP:0003552)1.92560284
68Lip pit (HP:0100267)1.92516736
69Abnormal drinking behavior (HP:0030082)1.92458473
70Polydipsia (HP:0001959)1.92458473
71Optic disc pallor (HP:0000543)1.91759182
72Abnormality of the pancreatic islet cells (HP:0006476)1.91586587
73Abnormality of endocrine pancreas physiology (HP:0012093)1.91586587
74Poor suck (HP:0002033)1.91081711
75Retinal dysplasia (HP:0007973)1.90936726
76Limb dystonia (HP:0002451)1.90677387
77Abnormal albumin level (HP:0012116)1.86217371
78Hypoalbuminemia (HP:0003073)1.86217371
79Megalencephaly (HP:0001355)1.86138957
80Thyroiditis (HP:0100646)1.82001755
81Agitation (HP:0000713)1.81558914
82Decreased circulating renin level (HP:0003351)1.81136916
83Congenital primary aphakia (HP:0007707)1.80862553
84Ketoacidosis (HP:0001993)1.80838461
85Amblyopia (HP:0000646)1.79452821
86Aplasia/Hypoplasia of the spleen (HP:0010451)1.79398935
87Neonatal respiratory distress (HP:0002643)1.78608376
88Limb hypertonia (HP:0002509)1.78176656
89Poor head control (HP:0002421)1.77165291
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77087623
91Abnormality of urine glucose concentration (HP:0011016)1.76727586
92Glycosuria (HP:0003076)1.76727586
93Muscle fiber atrophy (HP:0100295)1.75163135
94Large for gestational age (HP:0001520)1.73490564
95Hypoplasia of the thymus (HP:0000778)1.73007710
96Abnormality of the left ventricular outflow tract (HP:0011103)1.72775144
97Subaortic stenosis (HP:0001682)1.72775144
98Cystic liver disease (HP:0006706)1.72706435
99Exertional dyspnea (HP:0002875)1.72416959
100Nephrogenic diabetes insipidus (HP:0009806)1.72120876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.36706915
2ADRBK24.16548599
3MAP4K23.46532403
4ACVR1B3.07974325
5PHKG22.82789330
6PHKG12.82789330
7NUAK12.79889095
8TESK12.57664362
9MAPKAPK32.39044430
10STK161.95669592
11GRK11.85861399
12PAK31.84490640
13MAPKAPK51.66771840
14EPHA41.65398733
15MUSK1.61379935
16BMPR1B1.55997758
17TXK1.44421276
18PAK61.44116630
19TNK21.43888521
20CSNK1G21.42534338
21PINK11.39956026
22MAPK131.27879546
23TYRO31.19915932
24CSNK1G31.19503451
25OXSR11.18648693
26MARK11.18610731
27PRKCG1.15097551
28FES1.14910311
29CSNK1G11.10626100
30TAOK31.10625386
31WNK41.09858931
32ZAK1.09529911
33EIF2AK31.09170690
34KSR11.08794016
35CASK1.06875916
36CLK11.05823556
37ADRBK11.01523968
38MAP3K40.96983850
39STK390.96792228
40DAPK20.96138866
41PRKCE0.95552010
42EPHB20.95176340
43STK30.95049511
44CCNB10.93192161
45TSSK60.92662201
46NEK10.91773087
47WNK30.91067506
48MAP3K120.90828008
49MAP2K70.88876396
50PRKAA20.87483562
51VRK10.86077588
52NTRK20.85754475
53PIK3CA0.82870128
54ERBB20.82368028
55DAPK10.80611533
56FGFR20.79880481
57INSRR0.79845878
58NTRK10.76415793
59MARK30.74242128
60FER0.71816467
61ITK0.71714556
62TNIK0.71213882
63STK240.70544718
64MST40.69858493
65MAP3K110.69728904
66VRK20.67518233
67IRAK10.65279105
68TAF10.64975862
69MKNK20.62222106
70PIK3CG0.59687481
71DYRK20.59189958
72TAOK10.58488138
73STK380.57275090
74BUB10.56995871
75CAMK2A0.56573564
76PLK20.54930657
77ERBB30.53169279
78NLK0.52663679
79MINK10.51545078
80EIF2AK20.51042922
81CSNK1D0.50951295
82PLK30.50448045
83CSNK1A1L0.48779019
84LATS10.48765311
85TAOK20.47737895
86CSNK1A10.44434973
87IKBKB0.42425251
88PRKACA0.42305905
89TLK10.42075142
90TGFBR10.41129670
91CDK80.41036598
92MAP2K10.37816622
93STK38L0.37177004
94RPS6KA40.37063947
95PRKCQ0.36584063
96STK110.36271824
97TEC0.35721659
98PRKCB0.32867735
99RAF10.32866199
100MAP2K60.30276241

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72940295
2Nitrogen metabolism_Homo sapiens_hsa009102.35659857
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.34231670
4Oxidative phosphorylation_Homo sapiens_hsa001902.29821124
5Dorso-ventral axis formation_Homo sapiens_hsa043202.28857114
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.23268264
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20347718
8Caffeine metabolism_Homo sapiens_hsa002322.18891827
9Protein export_Homo sapiens_hsa030602.11369083
10Butanoate metabolism_Homo sapiens_hsa006502.11059207
11Nicotine addiction_Homo sapiens_hsa050332.04518562
12Parkinsons disease_Homo sapiens_hsa050122.01755271
13Linoleic acid metabolism_Homo sapiens_hsa005911.96320450
14Phototransduction_Homo sapiens_hsa047441.93003327
15RNA polymerase_Homo sapiens_hsa030201.84618949
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81728653
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77713901
18Tryptophan metabolism_Homo sapiens_hsa003801.73128624
19One carbon pool by folate_Homo sapiens_hsa006701.61963559
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58131441
21Cardiac muscle contraction_Homo sapiens_hsa042601.56800033
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52985999
23Morphine addiction_Homo sapiens_hsa050321.44379056
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43912157
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37797406
26Type I diabetes mellitus_Homo sapiens_hsa049401.35502441
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32214818
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.30428153
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28628190
30Alzheimers disease_Homo sapiens_hsa050101.28368086
31Taste transduction_Homo sapiens_hsa047421.28031064
32Proteasome_Homo sapiens_hsa030501.27131751
33beta-Alanine metabolism_Homo sapiens_hsa004101.25493706
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24339719
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23814466
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.23443804
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20100136
38Retinol metabolism_Homo sapiens_hsa008301.14637320
39Basal transcription factors_Homo sapiens_hsa030221.12149685
40Olfactory transduction_Homo sapiens_hsa047401.11817784
41Histidine metabolism_Homo sapiens_hsa003401.11365573
42Chemical carcinogenesis_Homo sapiens_hsa052041.08748722
43Circadian entrainment_Homo sapiens_hsa047131.08169558
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06484952
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05208931
46Sulfur relay system_Homo sapiens_hsa041221.04062514
47Serotonergic synapse_Homo sapiens_hsa047261.03801291
48Ether lipid metabolism_Homo sapiens_hsa005651.03672679
49Huntingtons disease_Homo sapiens_hsa050161.03217716
50Insulin secretion_Homo sapiens_hsa049111.02725793
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00365497
52Homologous recombination_Homo sapiens_hsa034400.99866282
53Propanoate metabolism_Homo sapiens_hsa006400.97605755
54Autoimmune thyroid disease_Homo sapiens_hsa053200.95346016
55Allograft rejection_Homo sapiens_hsa053300.91827045
56Primary immunodeficiency_Homo sapiens_hsa053400.91428166
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90351841
58GABAergic synapse_Homo sapiens_hsa047270.89887557
59Glycerolipid metabolism_Homo sapiens_hsa005610.89155943
60Ovarian steroidogenesis_Homo sapiens_hsa049130.89064886
61ABC transporters_Homo sapiens_hsa020100.88989538
62Salivary secretion_Homo sapiens_hsa049700.88144769
63Fanconi anemia pathway_Homo sapiens_hsa034600.87834438
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87245350
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82454314
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80234988
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78362085
68Graft-versus-host disease_Homo sapiens_hsa053320.78084579
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76046278
70Glutamatergic synapse_Homo sapiens_hsa047240.75971624
71Peroxisome_Homo sapiens_hsa041460.74594635
72Purine metabolism_Homo sapiens_hsa002300.74178279
73Calcium signaling pathway_Homo sapiens_hsa040200.73527695
74Sulfur metabolism_Homo sapiens_hsa009200.70443640
75Sphingolipid metabolism_Homo sapiens_hsa006000.67644876
76Pancreatic secretion_Homo sapiens_hsa049720.61664220
77Long-term depression_Homo sapiens_hsa047300.60059604
78Arachidonic acid metabolism_Homo sapiens_hsa005900.59933926
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.59438378
80RNA transport_Homo sapiens_hsa030130.57033498
81RNA degradation_Homo sapiens_hsa030180.56177204
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56003936
83Asthma_Homo sapiens_hsa053100.55588868
84Pyrimidine metabolism_Homo sapiens_hsa002400.55280010
85Regulation of autophagy_Homo sapiens_hsa041400.53617395
86Dopaminergic synapse_Homo sapiens_hsa047280.52967650
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51345053
88Metabolic pathways_Homo sapiens_hsa011000.50681382
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.50613235
90Starch and sucrose metabolism_Homo sapiens_hsa005000.49520258
91Steroid biosynthesis_Homo sapiens_hsa001000.49498216
92Selenocompound metabolism_Homo sapiens_hsa004500.49386523
93Amphetamine addiction_Homo sapiens_hsa050310.46403426
94Fat digestion and absorption_Homo sapiens_hsa049750.44936014
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.42001441
96Collecting duct acid secretion_Homo sapiens_hsa049660.41553294
97Mineral absorption_Homo sapiens_hsa049780.41410638
98Renin secretion_Homo sapiens_hsa049240.40864503
99Cocaine addiction_Homo sapiens_hsa050300.39363080
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39191138

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