SEPT7P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.34599277
2epithelial cilium movement (GO:0003351)5.20448424
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.93146859
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.83189161
5cilium movement (GO:0003341)4.66749030
6cell wall macromolecule metabolic process (GO:0044036)4.61538646
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.34485757
8NADH dehydrogenase complex assembly (GO:0010257)4.34485757
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34485757
10cytidine deamination (GO:0009972)4.23374842
11cytidine metabolic process (GO:0046087)4.23374842
12cytidine catabolic process (GO:0006216)4.23374842
13axoneme assembly (GO:0035082)4.15361731
14cilium or flagellum-dependent cell motility (GO:0001539)4.08446522
15peptidyl-histidine modification (GO:0018202)4.06523888
16ADP metabolic process (GO:0046031)3.98926349
17platelet dense granule organization (GO:0060155)3.98387935
18negative regulation of T-helper cell differentiation (GO:0045623)3.95959137
19negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.95959137
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.88296117
21axonemal dynein complex assembly (GO:0070286)3.87393240
22protein complex biogenesis (GO:0070271)3.72779675
23glucosamine-containing compound catabolic process (GO:1901072)3.68875800
24protein polyglutamylation (GO:0018095)3.64109696
25protein localization to cilium (GO:0061512)3.62785015
26organelle disassembly (GO:1903008)3.62609177
27pyrimidine ribonucleoside catabolic process (GO:0046133)3.58835215
28cilium morphogenesis (GO:0060271)3.48575785
29water-soluble vitamin biosynthetic process (GO:0042364)3.47828044
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39295614
31mitochondrial respiratory chain complex assembly (GO:0033108)3.38462654
32behavioral response to nicotine (GO:0035095)3.37354657
33replication fork processing (GO:0031297)3.35810248
34glycine transport (GO:0015816)3.32126713
35regulation of meiosis I (GO:0060631)3.30669246
36intraciliary transport (GO:0042073)3.26784361
37negative regulation of alpha-beta T cell differentiation (GO:0046639)3.26768589
38preassembly of GPI anchor in ER membrane (GO:0016254)3.20882331
39ATP synthesis coupled proton transport (GO:0015986)3.19803856
40energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19803856
41GPI anchor metabolic process (GO:0006505)3.19357165
42negative regulation of mast cell activation (GO:0033004)3.18443346
43piRNA metabolic process (GO:0034587)3.17462917
44response to pheromone (GO:0019236)3.14194809
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11201237
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09027860
47protein neddylation (GO:0045116)3.07353633
48gamma-aminobutyric acid transport (GO:0015812)3.07002508
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03735020
50regulation of rhodopsin mediated signaling pathway (GO:0022400)2.99227015
51rhodopsin mediated signaling pathway (GO:0016056)2.98467090
52negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96941159
53establishment of protein localization to mitochondrial membrane (GO:0090151)2.95378664
54interferon-gamma production (GO:0032609)2.92650185
55regulation of T-helper 1 cell differentiation (GO:0045625)2.92186244
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.91422973
57GPI anchor biosynthetic process (GO:0006506)2.90844677
58proline transport (GO:0015824)2.88749851
59respiratory electron transport chain (GO:0022904)2.85495909
60male meiosis I (GO:0007141)2.83205740
61electron transport chain (GO:0022900)2.82937540
62cilium organization (GO:0044782)2.81570754
63regulation of interleukin-12 biosynthetic process (GO:0045075)2.81320811
64ribonucleoprotein complex disassembly (GO:0032988)2.78424939
65regulation of T cell receptor signaling pathway (GO:0050856)2.78414481
66retinal cone cell development (GO:0046549)2.77777302
67motile cilium assembly (GO:0044458)2.76054245
68DNA demethylation (GO:0080111)2.73430743
69indole-containing compound catabolic process (GO:0042436)2.72707769
70indolalkylamine catabolic process (GO:0046218)2.72707769
71tryptophan catabolic process (GO:0006569)2.72707769
72nonmotile primary cilium assembly (GO:0035058)2.71743740
73positive regulation of defense response to virus by host (GO:0002230)2.71334116
74production of molecular mediator involved in inflammatory response (GO:0002532)2.69294287
75regulation of cilium movement (GO:0003352)2.68889813
76C-terminal protein amino acid modification (GO:0018410)2.67451650
77DNA double-strand break processing (GO:0000729)2.67165716
78chaperone-mediated protein transport (GO:0072321)2.65494266
79cellular ketone body metabolic process (GO:0046950)2.62008559
80cilium assembly (GO:0042384)2.61884078
81DNA methylation involved in gamete generation (GO:0043046)2.60510607
82protein-cofactor linkage (GO:0018065)2.59368040
83detection of light stimulus involved in visual perception (GO:0050908)2.59124876
84detection of light stimulus involved in sensory perception (GO:0050962)2.59124876
85respiratory chain complex IV assembly (GO:0008535)2.58607636
86positive regulation of chemokine secretion (GO:0090197)2.57657431
87L-fucose catabolic process (GO:0042355)2.57215648
88fucose catabolic process (GO:0019317)2.57215648
89L-fucose metabolic process (GO:0042354)2.57215648
90neural tube formation (GO:0001841)2.54224061
91glycolipid biosynthetic process (GO:0009247)2.53885222
92regulation of action potential (GO:0098900)2.53597911
93positive regulation of T-helper 1 type immune response (GO:0002827)2.51336938
94signal peptide processing (GO:0006465)2.51326351
95positive regulation of interleukin-1 beta secretion (GO:0050718)2.47018161
96C-terminal protein lipidation (GO:0006501)2.45392935
97prenylation (GO:0097354)2.43729730
98protein prenylation (GO:0018342)2.43729730
99protein K6-linked ubiquitination (GO:0085020)2.43698019
100negative regulation of T cell differentiation (GO:0045581)2.42460425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.89911956
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.40657466
3VDR_22108803_ChIP-Seq_LS180_Human3.33557145
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.73686513
5GBX2_23144817_ChIP-Seq_PC3_Human2.70188866
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69106163
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.45524883
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35386811
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.31415037
10EZH2_22144423_ChIP-Seq_EOC_Human2.30448124
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28848350
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28640224
13IGF1R_20145208_ChIP-Seq_DFB_Human2.26773676
14EWS_26573619_Chip-Seq_HEK293_Human2.23647460
15FUS_26573619_Chip-Seq_HEK293_Human2.07807216
16P300_19829295_ChIP-Seq_ESCs_Human1.99672145
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98584089
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96335429
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90102994
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.88995112
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88234483
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85628076
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82789028
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.81217138
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.76960012
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74914241
27VDR_23849224_ChIP-Seq_CD4+_Human1.74431939
28MYC_18940864_ChIP-ChIP_HL60_Human1.64225712
29ELK1_19687146_ChIP-ChIP_HELA_Human1.63373451
30TAF15_26573619_Chip-Seq_HEK293_Human1.60316226
31ER_23166858_ChIP-Seq_MCF-7_Human1.56360234
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51826772
33CBP_20019798_ChIP-Seq_JUKART_Human1.51744252
34IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51744252
35TP53_22573176_ChIP-Seq_HFKS_Human1.48224900
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46078852
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44646906
38BCAT_22108803_ChIP-Seq_LS180_Human1.43808220
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40963997
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39241104
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37905417
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36378725
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36094479
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33167955
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.32717304
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.31922521
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.31329954
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31329954
49STAT3_23295773_ChIP-Seq_U87_Human1.29910167
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29109522
51SMAD4_21799915_ChIP-Seq_A2780_Human1.29105038
52NANOG_19829295_ChIP-Seq_ESCs_Human1.27681113
53SOX2_19829295_ChIP-Seq_ESCs_Human1.27681113
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27395158
55TCF4_22108803_ChIP-Seq_LS180_Human1.26438790
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26083850
57AR_20517297_ChIP-Seq_VCAP_Human1.25983424
58IRF1_19129219_ChIP-ChIP_H3396_Human1.25888294
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25800265
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24261635
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23787464
62NCOR_22424771_ChIP-Seq_293T_Human1.23299867
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22853136
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20467947
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19726393
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19092164
67JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18906012
68HTT_18923047_ChIP-ChIP_STHdh_Human1.18203745
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15993844
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14668932
71GATA3_26560356_Chip-Seq_TH2_Human1.14376453
72TCF4_23295773_ChIP-Seq_U87_Human1.13342491
73HOXB7_26014856_ChIP-Seq_BT474_Human1.13294341
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12867812
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.12210725
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11972159
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11682855
78CDX2_22108803_ChIP-Seq_LS180_Human1.10846259
79ETS1_20019798_ChIP-Seq_JURKAT_Human1.10532826
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10480210
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.09596441
82AR_25329375_ChIP-Seq_VCAP_Human1.09426020
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.07884440
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07387876
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.06335958
86MYC_19829295_ChIP-Seq_ESCs_Human1.06326610
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05954313
88FOXP3_21729870_ChIP-Seq_TREG_Human1.04642888
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.04516595
90P53_22387025_ChIP-Seq_ESCs_Mouse1.04234081
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.03876881
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.03876213
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.03815281
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02615977
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.00954538
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99835538
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99411471
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99011278
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.97738690
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.97571938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.31013797
2MP0005551_abnormal_eye_electrophysiolog2.76183947
3MP0003787_abnormal_imprinting2.71021815
4MP0005671_abnormal_response_to2.67706087
5MP0000569_abnormal_digit_pigmentation2.60936689
6MP0003806_abnormal_nucleotide_metabolis2.53573079
7MP0001529_abnormal_vocalization2.36606717
8MP0004142_abnormal_muscle_tone2.17188640
9MP0001984_abnormal_olfaction2.17076219
10MP0002102_abnormal_ear_morphology2.13472824
11MP0002653_abnormal_ependyma_morphology2.13236784
12MP0006072_abnormal_retinal_apoptosis2.03425768
13MP0000427_abnormal_hair_cycle1.91693331
14MP0003011_delayed_dark_adaptation1.85123364
15MP0003646_muscle_fatigue1.84049622
16MP0008872_abnormal_physiological_respon1.82399789
17MP0005645_abnormal_hypothalamus_physiol1.80652962
18MP0005253_abnormal_eye_physiology1.72709840
19MP0008995_early_reproductive_senescence1.72367740
20MP0001986_abnormal_taste_sensitivity1.66703971
21MP0002876_abnormal_thyroid_physiology1.66617360
22MP0004147_increased_porphyrin_level1.64585662
23MP0002638_abnormal_pupillary_reflex1.59560375
24MP0001835_abnormal_antigen_presentation1.57874057
25MP0005084_abnormal_gallbladder_morpholo1.56525839
26MP0002138_abnormal_hepatobiliary_system1.55906948
27MP0001873_stomach_inflammation1.49401409
28MP0001968_abnormal_touch/_nociception1.47344579
29MP0002837_dystrophic_cardiac_calcinosis1.46594286
30MP0008875_abnormal_xenobiotic_pharmacok1.46346584
31MP0003718_maternal_effect1.45361852
32MP0002736_abnormal_nociception_after1.44504062
33MP0004043_abnormal_pH_regulation1.42617929
34MP0000372_irregular_coat_pigmentation1.39546069
35MP0008058_abnormal_DNA_repair1.39127020
36MP0000685_abnormal_immune_system1.38749381
37MP0004145_abnormal_muscle_electrophysio1.38334335
38MP0002928_abnormal_bile_duct1.36872667
39MP0009785_altered_susceptibility_to1.34344814
40MP0003195_calcinosis1.33872585
41MP0001486_abnormal_startle_reflex1.32915516
42MP0005085_abnormal_gallbladder_physiolo1.31011064
43MP0009745_abnormal_behavioral_response1.30176249
44MP0000647_abnormal_sebaceous_gland1.28531987
45MP0002163_abnormal_gland_morphology1.27470560
46MP0004381_abnormal_hair_follicle1.24861100
47MP0008775_abnormal_heart_ventricle1.24591182
48MP0001800_abnormal_humoral_immune1.22873274
49MP0004885_abnormal_endolymph1.21771216
50MP0002822_catalepsy1.21154467
51MP0002095_abnormal_skin_pigmentation1.20903464
52MP0002272_abnormal_nervous_system1.20002170
53MP0005075_abnormal_melanosome_morpholog1.19034740
54MP0008789_abnormal_olfactory_epithelium1.14276388
55MP0003136_yellow_coat_color1.13741314
56MP0002277_abnormal_respiratory_mucosa1.13328926
57MP0009046_muscle_twitch1.11696551
58MP0001790_abnormal_immune_system1.11651026
59MP0005387_immune_system_phenotype1.11651026
60MP0003866_abnormal_defecation1.10927594
61MP0004133_heterotaxia1.10587515
62MP0001905_abnormal_dopamine_level1.09991674
63MP0003786_premature_aging1.08813934
64MP0005646_abnormal_pituitary_gland1.06469108
65MP0006276_abnormal_autonomic_nervous1.05762939
66MP0005423_abnormal_somatic_nervous1.04849635
67MP0001764_abnormal_homeostasis1.04352246
68MP0006292_abnormal_olfactory_placode1.04215824
69MP0002734_abnormal_mechanical_nocicepti1.02885769
70MP0002572_abnormal_emotion/affect_behav1.00128442
71MP0001440_abnormal_grooming_behavior0.97356480
72MP0005195_abnormal_posterior_eye0.96642038
73MP0003121_genomic_imprinting0.95572742
74MP0002723_abnormal_immune_serum0.95444059
75MP0005000_abnormal_immune_tolerance0.94408415
76MP0002735_abnormal_chemical_nociception0.93751802
77MP0002160_abnormal_reproductive_system0.91774995
78MP0005389_reproductive_system_phenotype0.91232225
79MP0001502_abnormal_circadian_rhythm0.89315928
80MP0004215_abnormal_myocardial_fiber0.88849818
81MP0006036_abnormal_mitochondrial_physio0.88377269
82MP0001919_abnormal_reproductive_system0.88090971
83MP0005394_taste/olfaction_phenotype0.87898377
84MP0005499_abnormal_olfactory_system0.87898377
85MP0004742_abnormal_vestibular_system0.87187152
86MP0001929_abnormal_gametogenesis0.86967128
87MP0003880_abnormal_central_pattern0.85753024
88MP0003252_abnormal_bile_duct0.85047618
89MP0002557_abnormal_social/conspecific_i0.84697379
90MP0005379_endocrine/exocrine_gland_phen0.84557466
91MP0009384_cardiac_valve_regurgitation0.84216529
92MP0002148_abnormal_hypersensitivity_rea0.83676190
93MP0004484_altered_response_of0.82899658
94MP0001293_anophthalmia0.81166217
95MP0005410_abnormal_fertilization0.79625856
96MP0002751_abnormal_autonomic_nervous0.78472810
97MP0001501_abnormal_sleep_pattern0.78044680
98MP0001324_abnormal_eye_pigmentation0.77833038
99MP0000653_abnormal_sex_gland0.76574761
100MP0002234_abnormal_pharynx_morphology0.76349096

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.35870581
2True hermaphroditism (HP:0010459)4.12247459
3Abnormal ciliary motility (HP:0012262)4.00714624
4Pancreatic fibrosis (HP:0100732)3.91140181
5Methylmalonic acidemia (HP:0002912)3.62662500
6Abnormality of midbrain morphology (HP:0002418)3.60361658
7Molar tooth sign on MRI (HP:0002419)3.60361658
8Medial flaring of the eyebrow (HP:0010747)3.57445574
9Acute necrotizing encephalopathy (HP:0006965)3.53761988
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.52359908
11Absent/shortened dynein arms (HP:0200106)3.52359908
12Abnormal respiratory motile cilium physiology (HP:0012261)3.41513913
13Abnormal respiratory epithelium morphology (HP:0012253)3.31275350
14Abnormal respiratory motile cilium morphology (HP:0005938)3.31275350
15Hepatocellular necrosis (HP:0001404)3.29441241
16Congenital stationary night blindness (HP:0007642)3.27914760
17Mitochondrial inheritance (HP:0001427)3.27848190
18Nephronophthisis (HP:0000090)3.22072803
19Acute encephalopathy (HP:0006846)3.16536160
20Progressive macrocephaly (HP:0004481)3.06329359
21Abnormal mitochondria in muscle tissue (HP:0008316)3.04958066
22Increased CSF lactate (HP:0002490)3.02326264
23Hepatic necrosis (HP:0002605)3.02012333
24Attenuation of retinal blood vessels (HP:0007843)3.01415452
25Methylmalonic aciduria (HP:0012120)2.97347931
26Cystic liver disease (HP:0006706)2.92855509
27Abnormal number of erythroid precursors (HP:0012131)2.75796272
28Abnormality of the renal medulla (HP:0100957)2.69717179
29Gait imbalance (HP:0002141)2.66894969
30Congenital primary aphakia (HP:0007707)2.65177777
31IgG deficiency (HP:0004315)2.52161496
32Optic disc pallor (HP:0000543)2.51491900
33Sclerocornea (HP:0000647)2.50362619
34Abnormality of the renal cortex (HP:0011035)2.50135387
35Rhinitis (HP:0012384)2.48044524
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.46965040
37Cerebral edema (HP:0002181)2.46181659
38Abnormality of cells of the erythroid lineage (HP:0012130)2.42711445
39Hypothermia (HP:0002045)2.41811457
40Postaxial foot polydactyly (HP:0001830)2.40010166
41Pendular nystagmus (HP:0012043)2.39172556
423-Methylglutaconic aciduria (HP:0003535)2.33396264
43Chronic sinusitis (HP:0011109)2.32621793
44Hemiparesis (HP:0001269)2.31043064
45Progressive inability to walk (HP:0002505)2.31008128
46Increased serum lactate (HP:0002151)2.30402651
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.27547900
48T lymphocytopenia (HP:0005403)2.26306168
49Nephrogenic diabetes insipidus (HP:0009806)2.25970106
50Supernumerary spleens (HP:0009799)2.25621400
51Abnormality of T cell number (HP:0011839)2.24891147
52Congenital, generalized hypertrichosis (HP:0004540)2.23989206
53Abnormality of vitamin B metabolism (HP:0004340)2.22977074
54Congenital hepatic fibrosis (HP:0002612)2.20258016
55Male pseudohermaphroditism (HP:0000037)2.19441877
56Inability to walk (HP:0002540)2.17082498
57Hyperglycinuria (HP:0003108)2.16337621
58Keratoconus (HP:0000563)2.16058526
59Increased corneal curvature (HP:0100692)2.16058526
60Postaxial hand polydactyly (HP:0001162)2.15999668
61Abolished electroretinogram (ERG) (HP:0000550)2.12772691
62Abnormality of the labia minora (HP:0012880)2.11827573
63Abnormality of the vitamin B12 metabolism (HP:0004341)2.05085204
64Anencephaly (HP:0002323)2.05053193
65Bronchiectasis (HP:0002110)2.03951529
66Abnormality of alanine metabolism (HP:0010916)2.02280401
67Hyperalaninemia (HP:0003348)2.02280401
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02280401
69Abnormal rod and cone electroretinograms (HP:0008323)2.01699217
70Genetic anticipation (HP:0003743)1.98069231
71Concave nail (HP:0001598)1.97414918
72Decreased central vision (HP:0007663)1.96858842
73Lipid accumulation in hepatocytes (HP:0006561)1.94292508
74Atonic seizures (HP:0010819)1.94139824
75Chronic hepatic failure (HP:0100626)1.93529628
76Renal cortical cysts (HP:0000803)1.92544350
77Abnormal drinking behavior (HP:0030082)1.91684977
78Polydipsia (HP:0001959)1.91684977
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91295327
80Bile duct proliferation (HP:0001408)1.90917516
81Abnormal biliary tract physiology (HP:0012439)1.90917516
82Furrowed tongue (HP:0000221)1.90667504
83Lethargy (HP:0001254)1.89586226
84Abnormality of serine family amino acid metabolism (HP:0010894)1.89379878
85Abnormality of glycine metabolism (HP:0010895)1.89379878
86Stomatitis (HP:0010280)1.88544052
87Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87558216
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87558216
89Delayed CNS myelination (HP:0002188)1.87132899
90Vaginal atresia (HP:0000148)1.86592301
91Abnormality of the prostate (HP:0008775)1.86112806
92Stomach cancer (HP:0012126)1.85411950
93Hyperglycinemia (HP:0002154)1.83179623
94Genital tract atresia (HP:0001827)1.79470742
95Abnormal albumin level (HP:0012116)1.77946669
96Hypoalbuminemia (HP:0003073)1.77946669
97Thyroiditis (HP:0100646)1.77534738
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73459639
99Lactic acidosis (HP:0003128)1.73405723
100Widely spaced teeth (HP:0000687)1.72395124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.82626621
2TAOK33.67012839
3GRK13.41322113
4FRK3.25884459
5MAP4K23.20567591
6MAP3K42.26586106
7WNK42.18467713
8TLK12.16053193
9PINK12.15255093
10ADRBK21.97532162
11MST41.94960032
12WNK31.86047787
13MAPKAPK31.84403683
14MAPK131.73187745
15BCKDK1.67792804
16MAP4K11.64963669
17ZAK1.64900112
18CASK1.63905731
19NUAK11.60287854
20TEC1.55121436
21INSRR1.44464084
22PNCK1.38916578
23NME11.38839606
24ITK1.37332758
25ERBB31.36321937
26EPHA31.35624998
27KIT1.34867112
28BCR1.33988398
29MAP2K71.31837541
30TESK21.31282591
31STK391.30604978
32BMPR1B1.29167856
33OXSR11.25300816
34DYRK21.22194161
35MUSK1.21686600
36FLT31.15980423
37CSF1R1.12736883
38MAP3K121.12624157
39STK161.11226550
40ADRBK11.06501646
41RPS6KA41.02820479
42VRK10.92314569
43PRKCQ0.87940732
44CSNK1G20.87301522
45PIK3CA0.86244467
46MAP2K60.85028200
47ACVR1B0.82692230
48SYK0.81527903
49PRKCE0.80234793
50PHKG20.80130105
51PHKG10.80130105
52VRK20.78652906
53IKBKB0.77713186
54PAK30.76901980
55CCNB10.75131512
56MKNK20.72986505
57SRPK10.70903243
58OBSCN0.70167719
59PIK3CG0.66927319
60DYRK30.66054834
61PRKCG0.65146818
62RPS6KA50.64319258
63DAPK20.64308789
64GRK70.60052646
65PASK0.58278574
66TIE10.53256549
67BTK0.52568779
68CAMK2A0.51914223
69PTK2B0.50145082
70IGF1R0.49322417
71TNIK0.48362358
72ATR0.48323278
73STK38L0.46320551
74KDR0.45860863
75SGK4940.44759951
76SGK2230.44759951
77PRKACA0.44205589
78DAPK10.43933941
79GRK50.43785444
80NTRK20.43783133
81CAMK2D0.41937115
82WEE10.41425302
83MARK10.41349916
84LYN0.40463105
85CHUK0.39416527
86CAMKK20.38303287
87CSNK1G10.38230045
88SGK20.37497744
89PRKG10.37256319
90TGFBR10.36609621
91RPS6KA60.36429878
92CSNK1G30.36323018
93LCK0.35426399
94PRKCH0.34316353
95PAK60.33597458
96PLK20.33344900
97CSNK1A1L0.33033457
98MATK0.32959592
99MYLK0.30659235
100MAPK150.29303416

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.44569025
2Oxidative phosphorylation_Homo sapiens_hsa001903.26688795
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.06593326
4Protein export_Homo sapiens_hsa030602.65284165
5Parkinsons disease_Homo sapiens_hsa050122.61134230
6Nitrogen metabolism_Homo sapiens_hsa009102.43129900
7RNA polymerase_Homo sapiens_hsa030202.35754901
8Homologous recombination_Homo sapiens_hsa034402.08675433
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07727265
10Propanoate metabolism_Homo sapiens_hsa006402.03187697
11Proteasome_Homo sapiens_hsa030501.98270711
12Fanconi anemia pathway_Homo sapiens_hsa034601.93498437
13Primary immunodeficiency_Homo sapiens_hsa053401.85540600
14Nicotine addiction_Homo sapiens_hsa050331.82352214
15Ribosome_Homo sapiens_hsa030101.82045253
16Caffeine metabolism_Homo sapiens_hsa002321.80967589
17Huntingtons disease_Homo sapiens_hsa050161.77630135
18Graft-versus-host disease_Homo sapiens_hsa053321.75226739
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.68693870
20Alzheimers disease_Homo sapiens_hsa050101.64614432
21RNA degradation_Homo sapiens_hsa030181.61225840
22Basal transcription factors_Homo sapiens_hsa030221.57074390
23Linoleic acid metabolism_Homo sapiens_hsa005911.48828789
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44280340
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43700378
26Olfactory transduction_Homo sapiens_hsa047401.39422533
27Autoimmune thyroid disease_Homo sapiens_hsa053201.38543330
28Antigen processing and presentation_Homo sapiens_hsa046121.34539173
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32201260
30Allograft rejection_Homo sapiens_hsa053301.31724355
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29519487
32Cardiac muscle contraction_Homo sapiens_hsa042601.25206745
33Type I diabetes mellitus_Homo sapiens_hsa049401.23034748
34Asthma_Homo sapiens_hsa053101.22141519
35Purine metabolism_Homo sapiens_hsa002301.20244955
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15809606
37Butanoate metabolism_Homo sapiens_hsa006501.14465522
38Non-homologous end-joining_Homo sapiens_hsa034501.14354345
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12112260
40Sulfur metabolism_Homo sapiens_hsa009201.09786243
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09576100
42Chemical carcinogenesis_Homo sapiens_hsa052041.03594426
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.01744033
44SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01375631
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98956207
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97053044
47Rheumatoid arthritis_Homo sapiens_hsa053230.96720412
48Steroid hormone biosynthesis_Homo sapiens_hsa001400.93866185
49Taste transduction_Homo sapiens_hsa047420.89927159
50Morphine addiction_Homo sapiens_hsa050320.89716044
51GABAergic synapse_Homo sapiens_hsa047270.87335460
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86899979
53Circadian rhythm_Homo sapiens_hsa047100.85203597
54Salivary secretion_Homo sapiens_hsa049700.85135476
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84666746
56Tryptophan metabolism_Homo sapiens_hsa003800.83968503
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83252579
58Pyrimidine metabolism_Homo sapiens_hsa002400.81076494
59Retinol metabolism_Homo sapiens_hsa008300.77461805
60Circadian entrainment_Homo sapiens_hsa047130.76364784
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.76100859
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75839736
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75564874
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75421902
65One carbon pool by folate_Homo sapiens_hsa006700.73350952
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72737874
67Nucleotide excision repair_Homo sapiens_hsa034200.68878725
68Selenocompound metabolism_Homo sapiens_hsa004500.68114262
69Collecting duct acid secretion_Homo sapiens_hsa049660.66032788
70Peroxisome_Homo sapiens_hsa041460.63302246
71Ether lipid metabolism_Homo sapiens_hsa005650.63219812
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62179765
73Hematopoietic cell lineage_Homo sapiens_hsa046400.60178849
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59726397
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59023774
76Regulation of autophagy_Homo sapiens_hsa041400.58352432
77Metabolic pathways_Homo sapiens_hsa011000.57436122
78beta-Alanine metabolism_Homo sapiens_hsa004100.57284309
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56775587
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.56450306
81T cell receptor signaling pathway_Homo sapiens_hsa046600.55919405
82Pyruvate metabolism_Homo sapiens_hsa006200.54872277
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54725727
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53812529
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53583241
86Dorso-ventral axis formation_Homo sapiens_hsa043200.53102650
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50574633
88Ovarian steroidogenesis_Homo sapiens_hsa049130.40898976
89Arachidonic acid metabolism_Homo sapiens_hsa005900.40263279
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40181830
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.39394991
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38844328
93Sulfur relay system_Homo sapiens_hsa041220.38640739
94Calcium signaling pathway_Homo sapiens_hsa040200.38583755
95Steroid biosynthesis_Homo sapiens_hsa001000.37985820
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.37848807
97Systemic lupus erythematosus_Homo sapiens_hsa053220.37292717
98Spliceosome_Homo sapiens_hsa030400.35227732
99Insulin secretion_Homo sapiens_hsa049110.30389962
100Mineral absorption_Homo sapiens_hsa049780.30028391

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