SEPT7P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)9.52356455
2cytidine catabolic process (GO:0006216)9.52356455
3cytidine deamination (GO:0009972)9.52356455
4DNA deamination (GO:0045006)8.82577194
5pyrimidine ribonucleoside catabolic process (GO:0046133)8.37487508
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.02827663
7negative regulation by host of viral transcription (GO:0043922)4.41032062
8protein neddylation (GO:0045116)4.29636137
9pyrimidine nucleoside catabolic process (GO:0046135)4.23895872
10positive regulation of interleukin-8 secretion (GO:2000484)4.16050745
11eosinophil chemotaxis (GO:0048245)4.06155061
12Arp2/3 complex-mediated actin nucleation (GO:0034314)4.01488322
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.01256323
14proteasome assembly (GO:0043248)3.94927401
15positive thymic T cell selection (GO:0045059)3.79964229
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77380714
17actin nucleation (GO:0045010)3.75513470
18T cell migration (GO:0072678)3.75055303
19negative regulation of T cell apoptotic process (GO:0070233)3.73402771
20positive T cell selection (GO:0043368)3.70205945
21eosinophil migration (GO:0072677)3.67188226
22regulation of cellular amino acid metabolic process (GO:0006521)3.59355300
23positive regulation of B cell differentiation (GO:0045579)3.56138848
24ATP synthesis coupled proton transport (GO:0015986)3.56096362
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56096362
26negative regulation of viral genome replication (GO:0045071)3.52134530
27DNA demethylation (GO:0080111)3.51503595
28respiratory electron transport chain (GO:0022904)3.47392651
29DNA dealkylation (GO:0035510)3.44688498
30electron transport chain (GO:0022900)3.42521788
31platelet dense granule organization (GO:0060155)3.38748877
32cytolysis (GO:0019835)3.37754129
33regulation of interleukin-8 secretion (GO:2000482)3.34064621
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33361803
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29562475
36positive regulation of calcium-mediated signaling (GO:0050850)3.28309279
37positive regulation of defense response to virus by host (GO:0002230)3.21319354
38negative T cell selection (GO:0043383)3.21186387
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.20256211
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.20256211
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19327996
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19327996
43signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19327996
44cellular response to interleukin-15 (GO:0071350)3.15792174
45regulation of activation of Janus kinase activity (GO:0010533)3.13486053
46pyrimidine-containing compound catabolic process (GO:0072529)3.11748985
47regulation of T cell receptor signaling pathway (GO:0050856)3.10119155
48sequestering of actin monomers (GO:0042989)3.08665519
49negative regulation of B cell proliferation (GO:0030889)3.08121924
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05808422
51signal peptide processing (GO:0006465)3.05451673
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03785241
53regulation of lymphocyte chemotaxis (GO:1901623)3.01346182
54positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.00695179
55regulation of regulatory T cell differentiation (GO:0045589)3.00365223
56negative regulation of ligase activity (GO:0051352)2.97816579
57negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.97816579
58signal transduction involved in DNA integrity checkpoint (GO:0072401)2.97731039
59signal transduction involved in DNA damage checkpoint (GO:0072422)2.97731039
60regulation of chronic inflammatory response (GO:0002676)2.97013204
61signal transduction involved in cell cycle checkpoint (GO:0072395)2.96334536
62positive regulation of lymphocyte migration (GO:2000403)2.96157209
63positive regulation of natural killer cell mediated immunity (GO:0002717)2.93215504
64regulation of B cell differentiation (GO:0045577)2.91903228
65negative regulation of lymphocyte apoptotic process (GO:0070229)2.91758608
66macrophage chemotaxis (GO:0048246)2.90022918
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.86524743
68protein complex biogenesis (GO:0070271)2.85713310
69cytochrome complex assembly (GO:0017004)2.85154358
70respiratory chain complex IV assembly (GO:0008535)2.83668845
71T cell costimulation (GO:0031295)2.81766119
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.81472547
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81020664
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78652258
75lymphocyte costimulation (GO:0031294)2.78551703
76positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.75640549
77regulation of calcium-mediated signaling (GO:0050848)2.73214228
78positive regulation of alpha-beta T cell proliferation (GO:0046641)2.72417833
79regulation of B cell receptor signaling pathway (GO:0050855)2.70798736
80response to interferon-beta (GO:0035456)2.69570676
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69546241
82positive regulation of tolerance induction (GO:0002645)2.68828965
83regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.67376052
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65916833
85negative thymic T cell selection (GO:0045060)2.65570062
86piRNA metabolic process (GO:0034587)2.64495371
87DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.64082721
88regulation of cellular amine metabolic process (GO:0033238)2.63989077
89positive regulation of cell cycle arrest (GO:0071158)2.63867918
90tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62890501
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62890501
92positive regulation of monocyte chemotaxis (GO:0090026)2.62852197
93regulation of viral genome replication (GO:0045069)2.60733893
94positive regulation of T cell chemotaxis (GO:0010820)2.59468810
95regulation of T cell chemotaxis (GO:0010819)2.59468810
96negative regulation of T cell receptor signaling pathway (GO:0050860)2.58908200
97negative regulation of calcium ion transport into cytosol (GO:0010523)2.58037051
98regulation of alpha-beta T cell proliferation (GO:0046640)2.57892690
99positive regulation of ligase activity (GO:0051351)2.57466116
100negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.57419093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.20745223
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.66402884
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.19957548
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.13228389
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07154390
6VDR_22108803_ChIP-Seq_LS180_Human3.00069930
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.74191282
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72895765
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60106332
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.59897593
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55823239
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27715541
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.22512133
14ZNF274_21170338_ChIP-Seq_K562_Hela2.21733370
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16615665
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.14056831
17VDR_23849224_ChIP-Seq_CD4+_Human2.13217211
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.08598272
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04276308
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02591574
21IGF1R_20145208_ChIP-Seq_DFB_Human1.95843319
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91306762
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88220128
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83409413
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.77004783
26HTT_18923047_ChIP-ChIP_STHdh_Human1.74303920
27ELK1_19687146_ChIP-ChIP_HELA_Human1.73506272
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68640568
29MYB_26560356_Chip-Seq_TH2_Human1.65582522
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62274258
31GATA3_26560356_Chip-Seq_TH2_Human1.56433220
32FOXP3_21729870_ChIP-Seq_TREG_Human1.56316439
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.55963528
34EZH2_22144423_ChIP-Seq_EOC_Human1.55709023
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47839323
36EWS_26573619_Chip-Seq_HEK293_Human1.47292634
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.45299429
38SOX2_19829295_ChIP-Seq_ESCs_Human1.43875779
39NANOG_19829295_ChIP-Seq_ESCs_Human1.43875779
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43457641
41AR_20517297_ChIP-Seq_VCAP_Human1.43296438
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42853371
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41900861
44P300_19829295_ChIP-Seq_ESCs_Human1.39905880
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39083912
46TP53_22573176_ChIP-Seq_HFKS_Human1.38055457
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36948096
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33475001
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.33475001
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31146865
51FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30192250
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29900797
53ER_23166858_ChIP-Seq_MCF-7_Human1.29463516
54GATA3_27048872_Chip-Seq_THYMUS_Human1.28690439
55MYC_18940864_ChIP-ChIP_HL60_Human1.26212896
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24990375
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24563330
58RUNX_20019798_ChIP-Seq_JUKART_Human1.24144112
59NCOR_22424771_ChIP-Seq_293T_Human1.24111786
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22333406
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21306380
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.19173570
63PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18270858
64BCAT_22108803_ChIP-Seq_LS180_Human1.16753853
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16159219
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15280373
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15275779
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.15041440
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.14404111
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.14175720
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12021344
72TAF2_19829295_ChIP-Seq_ESCs_Human1.11828725
73GATA3_21878914_ChIP-Seq_MCF-7_Human1.10257911
74CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10081523
75FUS_26573619_Chip-Seq_HEK293_Human1.09989578
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09526859
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.07708451
78CBP_20019798_ChIP-Seq_JUKART_Human1.07139784
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07139784
80MYC_19829295_ChIP-Seq_ESCs_Human1.06104552
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05427307
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03648994
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03060842
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02005289
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01977475
86STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99357833
87CRX_20693478_ChIP-Seq_RETINA_Mouse0.98897159
88NANOG_20526341_ChIP-Seq_ESCs_Human0.98638553
89GBX2_23144817_ChIP-Seq_PC3_Human0.98424316
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97473833
91MYB_26560356_Chip-Seq_TH1_Human0.95254172
92ERG_20517297_ChIP-Seq_VCAP_Human0.93548196
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93089656
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.92741368
95EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92400968
96GATA3_26560356_Chip-Seq_TH1_Human0.90677278
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90382293
98CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88189282
99TAF15_26573619_Chip-Seq_HEK293_Human0.88027579
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87985586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.98915945
2MP0009785_altered_susceptibility_to2.73601109
3MP0002102_abnormal_ear_morphology2.71748933
4MP0001835_abnormal_antigen_presentation2.56683685
5MP0009333_abnormal_splenocyte_physiolog2.38629085
6MP0006072_abnormal_retinal_apoptosis2.35673480
7MP0003646_muscle_fatigue2.33979986
8MP0003763_abnormal_thymus_physiology2.25810429
9MP0004147_increased_porphyrin_level2.20889525
10MP0002148_abnormal_hypersensitivity_rea2.19387852
11MP0005000_abnormal_immune_tolerance2.04876085
12MP0003195_calcinosis2.03829486
13MP0001800_abnormal_humoral_immune1.96567594
14MP0004145_abnormal_muscle_electrophysio1.91550787
15MP0005360_urolithiasis1.87828707
16MP0001919_abnormal_reproductive_system1.83904146
17MP0001968_abnormal_touch/_nociception1.76630024
18MP0002420_abnormal_adaptive_immunity1.75839012
19MP0002723_abnormal_immune_serum1.75723231
20MP0002166_altered_tumor_susceptibility1.73598741
21MP0001790_abnormal_immune_system1.73041454
22MP0005387_immune_system_phenotype1.73041454
23MP0001905_abnormal_dopamine_level1.69951929
24MP0008877_abnormal_DNA_methylation1.69525123
25MP0001819_abnormal_immune_cell1.68772700
26MP0005025_abnormal_response_to1.66665910
27MP0005645_abnormal_hypothalamus_physiol1.63891529
28MP0000569_abnormal_digit_pigmentation1.63444879
29MP0008872_abnormal_physiological_respon1.60601812
30MP0006082_CNS_inflammation1.58191072
31MP0005253_abnormal_eye_physiology1.57912714
32MP0003045_fibrosis1.56768916
33MP0005551_abnormal_eye_electrophysiolog1.56734428
34MP0005075_abnormal_melanosome_morpholog1.55228027
35MP0002876_abnormal_thyroid_physiology1.52588131
36MP0001986_abnormal_taste_sensitivity1.49424100
37MP0003011_delayed_dark_adaptation1.48916595
38MP0002452_abnormal_antigen_presenting1.48089499
39MP0002736_abnormal_nociception_after1.47008084
40MP0002837_dystrophic_cardiac_calcinosis1.45047518
41MP0002277_abnormal_respiratory_mucosa1.43718466
42MP0002095_abnormal_skin_pigmentation1.42832676
43MP0005389_reproductive_system_phenotype1.41250304
44MP0003866_abnormal_defecation1.39343907
45MP0003806_abnormal_nucleotide_metabolis1.39182468
46MP0002006_tumorigenesis1.37726601
47MP0005084_abnormal_gallbladder_morpholo1.31357292
48MP0000716_abnormal_immune_system1.29965041
49MP0002398_abnormal_bone_marrow1.28270287
50MP0003880_abnormal_central_pattern1.27064953
51MP0000685_abnormal_immune_system1.24931213
52MP0009745_abnormal_behavioral_response1.23534380
53MP0001873_stomach_inflammation1.23417755
54MP0008875_abnormal_xenobiotic_pharmacok1.21907781
55MP0002733_abnormal_thermal_nociception1.20823400
56MP0005174_abnormal_tail_pigmentation1.19250367
57MP0003786_premature_aging1.17927505
58MP0002909_abnormal_adrenal_gland1.16995000
59MP0005464_abnormal_platelet_physiology1.14338034
60MP0000689_abnormal_spleen_morphology1.14064462
61MP0001845_abnormal_inflammatory_respons1.13645515
62MP0004043_abnormal_pH_regulation1.12807632
63MP0002638_abnormal_pupillary_reflex1.12196191
64MP0005410_abnormal_fertilization1.10499974
65MP0010155_abnormal_intestine_physiology1.06363832
66MP0000703_abnormal_thymus_morphology1.06003676
67MP0002933_joint_inflammation1.04866443
68MP0001970_abnormal_pain_threshold1.03361544
69MP0002693_abnormal_pancreas_physiology1.02161310
70MP0002405_respiratory_system_inflammati1.02071989
71MP0000372_irregular_coat_pigmentation1.01649327
72MP0010386_abnormal_urinary_bladder1.01301511
73MP0003448_altered_tumor_morphology1.00507951
74MP0002722_abnormal_immune_system1.00396550
75MP0002735_abnormal_chemical_nociception0.99029658
76MP0005167_abnormal_blood-brain_barrier0.95253713
77MP0002429_abnormal_blood_cell0.94759223
78MP0001984_abnormal_olfaction0.94081169
79MP0002272_abnormal_nervous_system0.93644869
80MP0000427_abnormal_hair_cycle0.93487390
81MP0006036_abnormal_mitochondrial_physio0.93360309
82MP0001542_abnormal_bone_strength0.90301422
83MP0008789_abnormal_olfactory_epithelium0.89124795
84MP0003724_increased_susceptibility_to0.89080170
85MP0001485_abnormal_pinna_reflex0.88827028
86MP0005636_abnormal_mineral_homeostasis0.85327765
87MP0004142_abnormal_muscle_tone0.83093709
88MP0009763_increased_sensitivity_to0.82647679
89MP0002419_abnormal_innate_immunity0.82505589
90MP0005646_abnormal_pituitary_gland0.82276132
91MP0002163_abnormal_gland_morphology0.80106989
92MP0006276_abnormal_autonomic_nervous0.78641347
93MP0000639_abnormal_adrenal_gland0.77424983
94MP0009764_decreased_sensitivity_to0.77091130
95MP0006292_abnormal_olfactory_placode0.76781509
96MP0003137_abnormal_impulse_conducting0.76352139
97MP0001853_heart_inflammation0.75363501
98MP0008469_abnormal_protein_level0.74986267
99MP0003075_altered_response_to0.73766647
100MP0002168_other_aberrant_phenotype0.73177834

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.09596835
2Congenital stationary night blindness (HP:0007642)4.24061101
3Hypoproteinemia (HP:0003075)4.00448637
4Mitochondrial inheritance (HP:0001427)3.84957785
5Acute necrotizing encephalopathy (HP:0006965)3.75479708
6Abnormality of T cell number (HP:0011839)3.73480324
7T lymphocytopenia (HP:0005403)3.72898151
8IgG deficiency (HP:0004315)3.72332751
9Severe combined immunodeficiency (HP:0004430)3.69088136
10Hepatocellular necrosis (HP:0001404)3.67173880
11Abnormal mitochondria in muscle tissue (HP:0008316)3.58744387
12Abnormality of the prostate (HP:0008775)3.51055675
133-Methylglutaconic aciduria (HP:0003535)3.42052609
14Increased CSF lactate (HP:0002490)3.38288317
15Hepatic necrosis (HP:0002605)3.37496335
16Thyroiditis (HP:0100646)3.24833155
17Acute encephalopathy (HP:0006846)3.20925950
18Progressive macrocephaly (HP:0004481)3.18072553
19Autoimmune hemolytic anemia (HP:0001890)3.15150995
20Elevated erythrocyte sedimentation rate (HP:0003565)3.13879707
21Abnormality of T cells (HP:0002843)2.90348685
22Agammaglobulinemia (HP:0004432)2.83461786
23Combined immunodeficiency (HP:0005387)2.79067153
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77217708
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77217708
26Pancreatic cysts (HP:0001737)2.76209025
27Increased intramyocellular lipid droplets (HP:0012240)2.71926938
28Renal cortical cysts (HP:0000803)2.69596508
29Panhypogammaglobulinemia (HP:0003139)2.66971944
30Abolished electroretinogram (ERG) (HP:0000550)2.64442576
31Methylmalonic aciduria (HP:0012120)2.61492553
32Increased IgM level (HP:0003496)2.56984102
33Hypoplasia of the thymus (HP:0000778)2.56190792
34Abnormality of eosinophils (HP:0001879)2.54271546
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.54073624
36Chronic diarrhea (HP:0002028)2.51414614
37Methylmalonic acidemia (HP:0002912)2.50733167
38Pancreatic fibrosis (HP:0100732)2.49905314
39Decreased central vision (HP:0007663)2.42539929
40Abnormality of midbrain morphology (HP:0002418)2.42410890
41Molar tooth sign on MRI (HP:0002419)2.42410890
42Pancytopenia (HP:0001876)2.40919849
43Increased hepatocellular lipid droplets (HP:0006565)2.38744799
44True hermaphroditism (HP:0010459)2.35599112
45Hypoalbuminemia (HP:0003073)2.32607262
46Abnormal albumin level (HP:0012116)2.32607262
47Abnormality of the renal cortex (HP:0011035)2.31777204
48Encephalitis (HP:0002383)2.30983542
49Lethargy (HP:0001254)2.30649445
50Cerebral edema (HP:0002181)2.30532811
51Abnormality of B cell number (HP:0010975)2.29969737
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.28899427
53Recurrent bronchitis (HP:0002837)2.27149774
54Increased serum lactate (HP:0002151)2.26666022
55Eosinophilia (HP:0001880)2.25718902
56Type I transferrin isoform profile (HP:0003642)2.24188431
57Lactic acidosis (HP:0003128)2.22009164
58Stomatitis (HP:0010280)2.19365513
59Hyperglycinemia (HP:0002154)2.18429374
60Dicarboxylic aciduria (HP:0003215)2.17920557
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17920557
62Attenuation of retinal blood vessels (HP:0007843)2.17529960
63Renal Fanconi syndrome (HP:0001994)2.16380333
64Medial flaring of the eyebrow (HP:0010747)2.15273415
65Increased muscle lipid content (HP:0009058)2.14484404
66Congenital, generalized hypertrichosis (HP:0004540)2.13109927
67Prostate neoplasm (HP:0100787)2.11783276
68Optic disc pallor (HP:0000543)2.11768148
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10840923
70Ketoacidosis (HP:0001993)2.10320420
71Abnormal rod and cone electroretinograms (HP:0008323)2.10308233
72Meningitis (HP:0001287)2.09419756
73Lipid accumulation in hepatocytes (HP:0006561)2.09144752
74Hypothermia (HP:0002045)2.07896455
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06708953
76Abnormality of alanine metabolism (HP:0010916)2.06708953
77Hyperalaninemia (HP:0003348)2.06708953
78Oral leukoplakia (HP:0002745)2.00900756
79Respiratory failure (HP:0002878)1.98728108
80Ketosis (HP:0001946)1.98281212
81IgM deficiency (HP:0002850)1.95513234
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.94910949
83B lymphocytopenia (HP:0010976)1.91080693
84CNS demyelination (HP:0007305)1.90760140
85Abnormality of male internal genitalia (HP:0000022)1.89707674
86Exercise intolerance (HP:0003546)1.84886201
87Chronic sinusitis (HP:0011109)1.84281433
88Leukocytosis (HP:0001974)1.82896366
89Severe visual impairment (HP:0001141)1.80497906
90Joint swelling (HP:0001386)1.80397155
91Reduced antithrombin III activity (HP:0001976)1.79387907
92Hemiplegia (HP:0002301)1.77205608
93Palpebral edema (HP:0100540)1.75476188
94Abnormality of T cell physiology (HP:0011840)1.75147710
95Keratoconus (HP:0000563)1.73654200
96Increased corneal curvature (HP:0100692)1.73654200
97Amyotrophic lateral sclerosis (HP:0007354)1.73058710
98Generalized aminoaciduria (HP:0002909)1.73056617
99Chronic obstructive pulmonary disease (HP:0006510)1.72799397
100Obstructive lung disease (HP:0006536)1.72799397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK26.32348967
2TXK5.41558564
3KDR4.13715520
4FRK2.51797225
5VRK22.49693680
6GRK12.46854060
7MST42.45747320
8BMPR1B2.27313613
9ITK2.22220622
10BCKDK2.12009029
11TAOK31.89673518
12ADRBK21.87660278
13NUAK11.85637138
14LIMK11.72425859
15MAP4K11.61509911
16TESK11.59507234
17BUB11.53996831
18EIF2AK31.49250792
19MAP4K21.48567871
20MAP3K121.45901910
21STK161.42902440
22FES1.42608511
23MUSK1.33388776
24ZAK1.31894359
25SYK1.29244872
26MAPK131.23379395
27VRK11.22240982
28PRKCQ1.19949021
29MAPKAPK31.19853587
30INSRR1.16476611
31TEC1.13374549
32MYLK1.11735559
33PIK3CA1.11405906
34WNK41.07086631
35WNK31.02838728
36TLK11.00366186
37EIF2AK10.97246188
38BCR0.89528501
39IKBKB0.88289054
40CSK0.87990276
41LCK0.87240546
42PINK10.85162262
43LYN0.79601752
44MAP2K60.79068103
45KIT0.78999024
46CDK80.78383963
47IKBKE0.75191526
48PLK20.75112729
49STK38L0.74438783
50GRK70.74329954
51ERBB30.74000492
52MAP3K110.73272004
53DAPK10.72473176
54CSF1R0.72413385
55MAP2K70.71284006
56CCNB10.65794854
57TRIM280.63882026
58DAPK20.62977688
59CASK0.58326215
60STK390.57715747
61PIK3CG0.56919079
62PIM20.55183871
63SRPK10.53619784
64ROCK10.53304726
65OXSR10.53255411
66IGF1R0.51879661
67TYRO30.50472151
68PRKCE0.48298807
69OBSCN0.48150146
70NME10.47830811
71CAMK2A0.47652304
72DYRK20.47016428
73BTK0.46368257
74RPS6KA50.45620274
75PRKCA0.44434045
76TIE10.44430204
77ZAP700.44311311
78TNK20.43278512
79TAF10.42517584
80FLT30.41647637
81PRKACA0.40522735
82ARAF0.40465984
83TBK10.39953876
84PRKCG0.38701747
85ACVR1B0.38525626
86ADRBK10.38350907
87FYN0.37640133
88MARK30.36818154
89GRK50.35623733
90INSR0.35381116
91CSNK1G30.35113950
92ATR0.33461510
93AURKA0.30927026
94PLK30.30326081
95CSNK2A10.30029100
96ABL10.29926120
97SCYL20.29552808
98MKNK20.27585597
99CSNK1G20.27083032
100ABL20.26620511

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.65034804
2Primary immunodeficiency_Homo sapiens_hsa053404.01630254
3Oxidative phosphorylation_Homo sapiens_hsa001903.46325315
4Graft-versus-host disease_Homo sapiens_hsa053323.15795934
5Parkinsons disease_Homo sapiens_hsa050122.94344805
6Autoimmune thyroid disease_Homo sapiens_hsa053202.84213447
7Protein export_Homo sapiens_hsa030602.73982155
8Allograft rejection_Homo sapiens_hsa053302.68442387
9Antigen processing and presentation_Homo sapiens_hsa046122.57794959
10Type I diabetes mellitus_Homo sapiens_hsa049402.47010954
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.32947188
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06055640
13Phototransduction_Homo sapiens_hsa047442.05524924
14Alzheimers disease_Homo sapiens_hsa050101.90575738
15Rheumatoid arthritis_Homo sapiens_hsa053231.86724035
16Hematopoietic cell lineage_Homo sapiens_hsa046401.74445130
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73739111
18Asthma_Homo sapiens_hsa053101.72633105
19RNA polymerase_Homo sapiens_hsa030201.70675011
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.69046182
21Homologous recombination_Homo sapiens_hsa034401.67789981
22Huntingtons disease_Homo sapiens_hsa050161.63810545
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61205402
24Cardiac muscle contraction_Homo sapiens_hsa042601.45528964
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42171951
26Propanoate metabolism_Homo sapiens_hsa006401.27006496
27Butanoate metabolism_Homo sapiens_hsa006501.17793370
28T cell receptor signaling pathway_Homo sapiens_hsa046601.17246939
29Fanconi anemia pathway_Homo sapiens_hsa034601.16793337
30Linoleic acid metabolism_Homo sapiens_hsa005911.16599934
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13820120
32Peroxisome_Homo sapiens_hsa041461.13766072
33Nitrogen metabolism_Homo sapiens_hsa009101.13073141
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01778082
35Olfactory transduction_Homo sapiens_hsa047400.98665632
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97741175
37Collecting duct acid secretion_Homo sapiens_hsa049660.95699176
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95074709
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94508417
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92081833
41Viral myocarditis_Homo sapiens_hsa054160.91449641
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91253236
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90047693
44Ribosome_Homo sapiens_hsa030100.86915624
45Sulfur metabolism_Homo sapiens_hsa009200.84315852
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.81782196
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81684391
48Basal transcription factors_Homo sapiens_hsa030220.77979794
49One carbon pool by folate_Homo sapiens_hsa006700.77895604
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.75108350
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74412051
52RNA degradation_Homo sapiens_hsa030180.74107839
53Measles_Homo sapiens_hsa051620.72401751
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.71736615
55Salmonella infection_Homo sapiens_hsa051320.70299383
56Caffeine metabolism_Homo sapiens_hsa002320.68703223
57Retinol metabolism_Homo sapiens_hsa008300.68579987
58Tryptophan metabolism_Homo sapiens_hsa003800.64005764
59Pyrimidine metabolism_Homo sapiens_hsa002400.63508354
60Fatty acid elongation_Homo sapiens_hsa000620.63437114
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62980411
62Chemical carcinogenesis_Homo sapiens_hsa052040.60648968
63Purine metabolism_Homo sapiens_hsa002300.59841563
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59485384
65Staphylococcus aureus infection_Homo sapiens_hsa051500.56819016
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.54648907
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.50982628
68Arachidonic acid metabolism_Homo sapiens_hsa005900.50840672
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50658650
70Nicotine addiction_Homo sapiens_hsa050330.49485421
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48257736
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46345941
73Systemic lupus erythematosus_Homo sapiens_hsa053220.46303793
74Ether lipid metabolism_Homo sapiens_hsa005650.46182176
75Non-homologous end-joining_Homo sapiens_hsa034500.45521481
76Metabolic pathways_Homo sapiens_hsa011000.45267392
77Shigellosis_Homo sapiens_hsa051310.41060790
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40900280
79ABC transporters_Homo sapiens_hsa020100.38846788
80Mineral absorption_Homo sapiens_hsa049780.37993039
81Nucleotide excision repair_Homo sapiens_hsa034200.36172312
82Taste transduction_Homo sapiens_hsa047420.35702488
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34493272
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.34229604
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30852761
86Mismatch repair_Homo sapiens_hsa034300.27555254
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.26700154
88Regulation of autophagy_Homo sapiens_hsa041400.25719068
89beta-Alanine metabolism_Homo sapiens_hsa004100.25530998
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25482396
91Salivary secretion_Homo sapiens_hsa049700.24608711
92Morphine addiction_Homo sapiens_hsa050320.23402808
93Legionellosis_Homo sapiens_hsa051340.23270557
94Herpes simplex infection_Homo sapiens_hsa051680.22344465
95Renin secretion_Homo sapiens_hsa049240.17734080
96Epstein-Barr virus infection_Homo sapiens_hsa051690.17534694
97Fatty acid degradation_Homo sapiens_hsa000710.16665045
98Amphetamine addiction_Homo sapiens_hsa050310.16455146
99Malaria_Homo sapiens_hsa051440.15849035
100GABAergic synapse_Homo sapiens_hsa047270.15375975

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