SEPT7P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of timing of cell differentiation (GO:0048505)7.09273855
2astrocyte differentiation (GO:0048708)6.73392614
3regulation of development, heterochronic (GO:0040034)6.23742402
4hindbrain development (GO:0030902)5.39744424
5dorsal/ventral axis specification (GO:0009950)5.26512468
6positive regulation of cell fate commitment (GO:0010455)5.15862040
7glandular epithelial cell development (GO:0002068)4.55281766
8negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.47816541
9DNA deamination (GO:0045006)4.30872851
10response to xenobiotic stimulus (GO:0009410)4.30139651
11protein neddylation (GO:0045116)4.27513053
12peptidyl-histidine modification (GO:0018202)4.24205446
13positive regulation of neuroblast proliferation (GO:0002052)4.23482209
14artery development (GO:0060840)4.05149276
15response to nitrosative stress (GO:0051409)3.98521734
16pituitary gland development (GO:0021983)3.90088048
17glandular epithelial cell differentiation (GO:0002067)3.86481127
18negative regulation of T cell differentiation in thymus (GO:0033085)3.82881589
19neuron fate commitment (GO:0048663)3.65831010
20regulation of interferon-alpha production (GO:0032647)3.64684958
21keratinocyte development (GO:0003334)3.62436242
22positive regulation of interferon-alpha production (GO:0032727)3.61656418
23signal transduction involved in regulation of gene expression (GO:0023019)3.58151051
24S-adenosylmethionine metabolic process (GO:0046500)3.51676739
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.47821038
26ATP synthesis coupled proton transport (GO:0015986)3.47821038
27columnar/cuboidal epithelial cell development (GO:0002066)3.45389112
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.35652616
29L-fucose catabolic process (GO:0042355)3.35303093
30fucose catabolic process (GO:0019317)3.35303093
31L-fucose metabolic process (GO:0042354)3.35303093
32gland morphogenesis (GO:0022612)3.33589487
33maturation of SSU-rRNA (GO:0030490)3.31225077
34proteasome assembly (GO:0043248)3.30911753
35regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.29698665
36chaperone-mediated protein transport (GO:0072321)3.28554290
37regulation of cell fate specification (GO:0042659)3.26212267
38photoreceptor cell development (GO:0042461)3.22231993
39protein peptidyl-prolyl isomerization (GO:0000413)3.11905265
40RNA destabilization (GO:0050779)3.11847948
41regulation of neuroblast proliferation (GO:1902692)3.10516778
42regulation of transcription involved in cell fate commitment (GO:0060850)3.10400802
43histone H3-K9 methylation (GO:0051567)3.03423143
44exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00452475
45cellular response to ATP (GO:0071318)2.98908665
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98881433
47eye photoreceptor cell development (GO:0042462)2.95361245
48mitochondrion degradation (GO:0000422)2.94698278
49regulation of T-helper 1 cell differentiation (GO:0045625)2.92958708
50ribosomal small subunit assembly (GO:0000028)2.85277570
51pseudouridine synthesis (GO:0001522)2.83722226
52establishment of protein localization to mitochondrial membrane (GO:0090151)2.81227239
53indolalkylamine metabolic process (GO:0006586)2.77955194
54negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.77142000
55cullin deneddylation (GO:0010388)2.76351160
56negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.75301130
57lens development in camera-type eye (GO:0002088)2.73615036
58viral mRNA export from host cell nucleus (GO:0046784)2.70301242
59replication fork processing (GO:0031297)2.69039594
60aldehyde catabolic process (GO:0046185)2.68592016
61negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.68087806
62intestinal epithelial cell development (GO:0060576)2.68000089
63heparan sulfate proteoglycan metabolic process (GO:0030201)2.65994050
64L-ascorbic acid metabolic process (GO:0019852)2.64436123
65cysteine metabolic process (GO:0006534)2.60901893
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59953377
67transcription elongation from RNA polymerase I promoter (GO:0006362)2.58531443
68negative regulation of macrophage differentiation (GO:0045650)2.58363227
69mitotic G2 DNA damage checkpoint (GO:0007095)2.57529669
70regulation of thymocyte apoptotic process (GO:0070243)2.56740830
71regulation of hexokinase activity (GO:1903299)2.56457293
72regulation of glucokinase activity (GO:0033131)2.56457293
73electron transport chain (GO:0022900)2.56329828
74respiratory electron transport chain (GO:0022904)2.56046489
75histone mRNA metabolic process (GO:0008334)2.55124357
76hydrogen ion transmembrane transport (GO:1902600)2.54663208
77signal peptide processing (GO:0006465)2.53625225
78protein deneddylation (GO:0000338)2.53493825
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.47919811
80mitotic G2/M transition checkpoint (GO:0044818)2.47043247
81motile cilium assembly (GO:0044458)2.46804343
82response to peptidoglycan (GO:0032494)2.46793551
83positive regulation of lymphocyte apoptotic process (GO:0070230)2.46452920
84estrogen biosynthetic process (GO:0006703)2.46402575
85negative regulation of cell cycle G2/M phase transition (GO:1902750)2.46063464
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.45259706
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.45259706
88regulation of cell fate commitment (GO:0010453)2.43862262
89platelet dense granule organization (GO:0060155)2.43782575
90neural tube formation (GO:0001841)2.43754028
91positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.42487117
92branch elongation of an epithelium (GO:0060602)2.42461417
93protein targeting to mitochondrion (GO:0006626)2.41725027
94centriole assembly (GO:0098534)2.39631335
95regulation of interleukin-8 biosynthetic process (GO:0045414)2.39415839
96cilium morphogenesis (GO:0060271)2.38593890
97male meiosis I (GO:0007141)2.37940824
98termination of RNA polymerase I transcription (GO:0006363)2.37831184
99synapsis (GO:0007129)2.37409823
100cornea development in camera-type eye (GO:0061303)10.4958520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.88441826
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.61025696
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12156665
4FLI1_27457419_Chip-Seq_LIVER_Mouse3.11109871
5VDR_22108803_ChIP-Seq_LS180_Human2.83845697
6ZNF274_21170338_ChIP-Seq_K562_Hela2.72419008
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54213651
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.43424330
9EWS_26573619_Chip-Seq_HEK293_Human2.30367516
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30213700
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25904374
12ELK1_19687146_ChIP-ChIP_HELA_Human2.23968272
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18000002
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13424976
15EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.10825559
16VDR_23849224_ChIP-Seq_CD4+_Human2.09026847
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.08055135
18P300_19829295_ChIP-Seq_ESCs_Human2.04211609
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.02930998
20IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.91515388
21CBP_20019798_ChIP-Seq_JUKART_Human1.91515388
22MYC_18940864_ChIP-ChIP_HL60_Human1.86532790
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84979811
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81180049
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.78237609
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78175084
27TP53_22573176_ChIP-Seq_HFKS_Human1.71437856
28FUS_26573619_Chip-Seq_HEK293_Human1.69910964
29GBX2_23144817_ChIP-Seq_PC3_Human1.69628365
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64455723
31IGF1R_20145208_ChIP-Seq_DFB_Human1.62396538
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.60172754
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50469711
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.49643756
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49298998
36AR_20517297_ChIP-Seq_VCAP_Human1.47683808
37TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45008711
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40453429
39SOX2_19829295_ChIP-Seq_ESCs_Human1.39746878
40NANOG_19829295_ChIP-Seq_ESCs_Human1.39746878
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38294170
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38026453
43TAF15_26573619_Chip-Seq_HEK293_Human1.37152563
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36401401
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36300687
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.36300687
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.35653810
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35489749
49FOXP3_21729870_ChIP-Seq_TREG_Human1.35174061
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34836213
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34200117
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.32003268
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31582534
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30891178
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29613806
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.29172316
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27300756
58AHR_22903824_ChIP-Seq_MCF-7_Human1.24451417
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22242247
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.22150138
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19927091
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19046025
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18215894
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17292272
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16840130
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.16633833
67ERG_20517297_ChIP-Seq_VCAP_Human1.15105518
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14339045
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.13803231
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13739605
71EGR1_19032775_ChIP-ChIP_M12_Human1.12525822
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12395930
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12029480
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10381944
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.07721744
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06349843
77TAF2_19829295_ChIP-Seq_ESCs_Human1.04940618
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04873688
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.04609644
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04372705
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04372705
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04010611
83ER_23166858_ChIP-Seq_MCF-7_Human1.03101058
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02753289
85TTF2_22483619_ChIP-Seq_HELA_Human1.01326396
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.01192147
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.00799204
88BCAT_22108803_ChIP-Seq_LS180_Human1.00396311
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.00362100
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99961009
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99715762
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.98937005
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98441268
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.98425233
95STAT3_23295773_ChIP-Seq_U87_Human0.98250245
96RUNX2_22187159_ChIP-Seq_PCA_Human0.96975996
97HTT_18923047_ChIP-ChIP_STHdh_Human0.96942663
98ERA_21632823_ChIP-Seq_H3396_Human0.95021809
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94978165
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94778753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode7.92593153
2MP0005257_abnormal_intraocular_pressure6.07049983
3MP0002638_abnormal_pupillary_reflex5.37840806
4MP0008789_abnormal_olfactory_epithelium4.50116856
5MP0005394_taste/olfaction_phenotype3.48916829
6MP0005499_abnormal_olfactory_system3.48916829
7MP0003787_abnormal_imprinting2.92206905
8MP0008877_abnormal_DNA_methylation2.91584390
9MP0002938_white_spotting2.77493978
10MP0003806_abnormal_nucleotide_metabolis2.72272784
11MP0003283_abnormal_digestive_organ2.57334527
12MP0008057_abnormal_DNA_replication2.32010895
13MP0002160_abnormal_reproductive_system2.02634190
14MP0000613_abnormal_salivary_gland2.01176834
15MP0001835_abnormal_antigen_presentation1.93874952
16MP0002138_abnormal_hepatobiliary_system1.93672398
17MP0006054_spinal_hemorrhage1.79707077
18MP0002102_abnormal_ear_morphology1.58037327
19MP0003121_genomic_imprinting1.57311313
20MP0004145_abnormal_muscle_electrophysio1.48757295
21MP0000569_abnormal_digit_pigmentation1.46531338
22MP0001986_abnormal_taste_sensitivity1.33337633
23MP0002876_abnormal_thyroid_physiology1.32856536
24MP0005389_reproductive_system_phenotype1.30777076
25MP0003252_abnormal_bile_duct1.26473407
26MP0001919_abnormal_reproductive_system1.23759658
27MP0003724_increased_susceptibility_to1.21284707
28MP0008875_abnormal_xenobiotic_pharmacok1.20127273
29MP0005645_abnormal_hypothalamus_physiol1.18569154
30MP0004142_abnormal_muscle_tone1.17878428
31MP0009046_muscle_twitch1.16145875
32MP0005084_abnormal_gallbladder_morpholo1.13241858
33MP0005671_abnormal_response_to1.10327704
34MP0001324_abnormal_eye_pigmentation1.07788604
35MP0003646_muscle_fatigue1.06669431
36MP0004133_heterotaxia1.03940039
37MP0006072_abnormal_retinal_apoptosis1.03622967
38MP0001800_abnormal_humoral_immune1.02337497
39MP0005551_abnormal_eye_electrophysiolog1.02156240
40MP0008872_abnormal_physiological_respon1.01956265
41MP0001790_abnormal_immune_system0.95648368
42MP0005387_immune_system_phenotype0.95648368
43MP0000049_abnormal_middle_ear0.94309195
44MP0002163_abnormal_gland_morphology0.92650934
45MP0009785_altered_susceptibility_to0.90594540
46MP0005410_abnormal_fertilization0.90479194
47MP0001529_abnormal_vocalization0.89554320
48MP0010155_abnormal_intestine_physiology0.87985323
49MP0003786_premature_aging0.87815571
50MP0008995_early_reproductive_senescence0.87313300
51MP0001968_abnormal_touch/_nociception0.86015593
52MP0002177_abnormal_outer_ear0.85489374
53MP0002837_dystrophic_cardiac_calcinosis0.85107935
54MP0000685_abnormal_immune_system0.83508952
55MP0000428_abnormal_craniofacial_morphol0.82959441
56MP0003186_abnormal_redox_activity0.82072468
57MP0004742_abnormal_vestibular_system0.81316884
58MP0003937_abnormal_limbs/digits/tail_de0.80169956
59MP0009379_abnormal_foot_pigmentation0.80155173
60MP0002736_abnormal_nociception_after0.79146491
61MP0002277_abnormal_respiratory_mucosa0.78058549
62MP0005646_abnormal_pituitary_gland0.77231193
63MP0003195_calcinosis0.75183909
64MP0001944_abnormal_pancreas_morphology0.73688395
65MP0005253_abnormal_eye_physiology0.70742365
66MP0000631_abnormal_neuroendocrine_gland0.68931978
67MP0002282_abnormal_trachea_morphology0.68070320
68MP0000778_abnormal_nervous_system0.67641104
69MP0003866_abnormal_defecation0.67260103
70MP0000427_abnormal_hair_cycle0.66273546
71MP0005423_abnormal_somatic_nervous0.66051689
72MP0006276_abnormal_autonomic_nervous0.65934667
73MP0003567_abnormal_fetal_cardiomyocyte0.63855503
74MP0005167_abnormal_blood-brain_barrier0.63591116
75MP0005266_abnormal_metabolism0.63359907
76MP0009053_abnormal_anal_canal0.62961087
77MP0001293_anophthalmia0.62741268
78MP0001119_abnormal_female_reproductive0.62587895
79MP0002735_abnormal_chemical_nociception0.62531011
80MP0004019_abnormal_vitamin_homeostasis0.60958360
81MP0005195_abnormal_posterior_eye0.59570387
82MP0000750_abnormal_muscle_regeneration0.58872819
83MP0001485_abnormal_pinna_reflex0.58313431
84MP0002095_abnormal_skin_pigmentation0.57896346
85MP0009764_decreased_sensitivity_to0.57587027
86MP0001501_abnormal_sleep_pattern0.57497615
87MP0001340_abnormal_eyelid_morphology0.56455118
88MP0002452_abnormal_antigen_presenting0.56154865
89MP0003137_abnormal_impulse_conducting0.55882540
90MP0002693_abnormal_pancreas_physiology0.55451695
91MP0002723_abnormal_immune_serum0.54820767
92MP0002751_abnormal_autonomic_nervous0.54761259
93MP0003890_abnormal_embryonic-extraembry0.54552561
94MP0005187_abnormal_penis_morphology0.51622684
95MP0000647_abnormal_sebaceous_gland0.50943112
96MP0002109_abnormal_limb_morphology0.50863054
97MP0004885_abnormal_endolymph0.50768556
98MP0002272_abnormal_nervous_system0.50664870
99MP0001286_abnormal_eye_development0.50225378
100MP0000653_abnormal_sex_gland0.49928363

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the fovea (HP:0007750)7.65828194
2Aplasia/Hypoplasia of the fovea (HP:0008060)7.65828194
3Abnormality of the fovea (HP:0000493)6.11260279
4Aplasia/Hypoplasia of the macula (HP:0008059)5.03698300
5Optic nerve coloboma (HP:0000588)4.91193096
6Aplasia/Hypoplasia affecting the retina (HP:0008061)4.67868899
7Optic nerve hypoplasia (HP:0000609)3.52038853
8Aplasia/Hypoplasia of the optic nerve (HP:0008058)3.50249063
9Molar tooth sign on MRI (HP:0002419)3.15771964
10Abnormality of midbrain morphology (HP:0002418)3.15771964
11Abnormality of the fetal cardiovascular system (HP:0010948)2.95882845
12Abnormal umbilical cord blood vessels (HP:0011403)2.95882845
13Single umbilical artery (HP:0001195)2.95882845
14Oligodactyly (hands) (HP:0001180)2.93858063
15Keratitis (HP:0000491)2.90551218
16Short middle phalanx of the 5th finger (HP:0004220)2.84165424
17Congenital stationary night blindness (HP:0007642)2.81522660
18Chronic mucocutaneous candidiasis (HP:0002728)2.76854821
19Recurrent cutaneous fungal infections (HP:0011370)2.76854821
20Abnormality of the labia minora (HP:0012880)2.74725891
21Pancreatic islet-cell hyperplasia (HP:0004510)2.74116124
22Abnormality of the aortic arch (HP:0012303)2.72913039
23Hip contracture (HP:0003273)2.62745249
24Difficulty running (HP:0009046)2.60309053
25Cheilitis (HP:0100825)2.55130347
26Congenital, generalized hypertrichosis (HP:0004540)2.49725011
27Abnormality of the 4th metacarpal (HP:0010012)2.44452292
28Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.41216797
29Pancreatic cysts (HP:0001737)2.40750411
30Acute necrotizing encephalopathy (HP:0006965)2.39106329
31Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.33683207
32Thyroiditis (HP:0100646)2.32032195
33Severe combined immunodeficiency (HP:0004430)2.30464934
34Thyroid-stimulating hormone excess (HP:0002925)2.29339505
35Abnormality of the phalanges of the 5th finger (HP:0004213)2.28492251
36Ectopic kidney (HP:0000086)2.28089601
37Retinal dysplasia (HP:0007973)2.25513297
38Aplasia/Hypoplasia of the lens (HP:0008063)2.22694749
39Oligodactyly (HP:0012165)2.19396054
40Esophageal atresia (HP:0002032)2.17304831
41Progressive inability to walk (HP:0002505)2.16366066
42Mitochondrial inheritance (HP:0001427)2.15992292
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.15966538
44Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.11386811
45Sclerocornea (HP:0000647)2.09852859
46Abnormality of the ileum (HP:0001549)2.09646459
47Hip dysplasia (HP:0001385)2.07182568
48Absent radius (HP:0003974)2.05450341
49IgG deficiency (HP:0004315)2.04992539
50Abnormality of the renal cortex (HP:0011035)2.03055175
51Stomatitis (HP:0010280)2.01578065
52Absent phalangeal crease (HP:0006109)2.00450420
53Steatorrhea (HP:0002570)1.99141771
54Adrenal hypoplasia (HP:0000835)1.98917524
55Aplasia involving forearm bones (HP:0009822)1.97964319
56Absent forearm bone (HP:0003953)1.97964319
57Abnormal rod and cone electroretinograms (HP:0008323)1.96108977
58Hypoproteinemia (HP:0003075)1.95973587
59Triphalangeal thumb (HP:0001199)1.95942228
60Hepatic necrosis (HP:0002605)1.95435471
61Volvulus (HP:0002580)1.95265477
62Progressive macrocephaly (HP:0004481)1.94997636
63Symphalangism affecting the phalanges of the hand (HP:0009773)1.94477874
64Congenital glaucoma (HP:0001087)1.93891617
65Abnormal mitochondria in muscle tissue (HP:0008316)1.93859157
66Meckel diverticulum (HP:0002245)1.93818682
67Panhypogammaglobulinemia (HP:0003139)1.91572585
68Fair hair (HP:0002286)1.90875285
69Increased CSF lactate (HP:0002490)1.88651777
70Recurrent fungal infections (HP:0002841)1.88062147
71Gastrointestinal atresia (HP:0002589)1.87465676
72Acute encephalopathy (HP:0006846)1.87152036
73Hepatocellular necrosis (HP:0001404)1.84380805
74Supernumerary spleens (HP:0009799)1.83425545
75Abnormal finger flexion creases (HP:0006143)1.82656129
76Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82628353
77Abnormality of the umbilical cord (HP:0010881)1.82089237
78Hyperinsulinemic hypoglycemia (HP:0000825)1.80608915
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.80565279
80Keratoconus (HP:0000563)1.79918123
81Increased corneal curvature (HP:0100692)1.79918123
82True hermaphroditism (HP:0010459)1.79743485
83Pendular nystagmus (HP:0012043)1.78842001
84Combined immunodeficiency (HP:0005387)1.77470414
85Mask-like facies (HP:0000298)1.76683754
86Abnormality of DNA repair (HP:0003254)1.76289503
87Large eyes (HP:0001090)1.75393556
88Optic disc pallor (HP:0000543)1.75322927
89Abnormality of the middle phalanges of the toes (HP:0010183)1.74974002
90Inability to walk (HP:0002540)1.73807872
91Congenital malformation of the right heart (HP:0011723)1.72960444
92Double outlet right ventricle (HP:0001719)1.72960444
93Methylmalonic acidemia (HP:0002912)1.72208052
94Hyperglycinuria (HP:0003108)1.69510639
95Anencephaly (HP:0002323)1.69210627
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.67414634
97Absent/shortened dynein arms (HP:0200106)1.67414634
9811 pairs of ribs (HP:0000878)1.66911827
99Progressive microcephaly (HP:0000253)1.65660758
100Limited hip movement (HP:0008800)1.65329145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.78385990
2VRK23.27876482
3HIPK23.20987485
4BCKDK3.18670669
5PTK2B2.94374375
6MAPK132.91983424
7MAP3K122.71371208
8FRK2.71321723
9GRK12.42912289
10WNK32.26935398
11DYRK22.05954784
12TRIM281.94299032
13CDK191.90255285
14BMPR21.89751711
15TXK1.89110082
16CDK81.86884625
17TAOK31.81052471
18TGFBR11.72155220
19STK161.70791741
20NUAK11.67093228
21WNK41.53864758
22SRPK11.47275545
23INSRR1.44013404
24ZAK1.43672521
25MST41.41435563
26MYLK1.27553952
27MKNK21.26401585
28TAF11.25705438
29WEE11.17516075
30TSSK61.17228773
31KIT1.16412329
32VRK11.09770637
33ERBB31.08921685
34NEK11.02421515
35OXSR10.99063224
36ADRBK20.97982266
37TIE10.97102208
38TLK10.95410807
39CDK70.89830654
40PLK30.88573177
41PLK20.88013733
42STK390.81183190
43FES0.80507073
44ACVR1B0.80476881
45STK38L0.80339791
46TNIK0.80081297
47PHKG20.79574726
48PHKG10.79574726
49IKBKB0.79242931
50EIF2AK30.77387284
51PRKCH0.77364951
52GRK50.75059387
53DAPK30.73770769
54RIPK40.70547664
55WNK10.69286277
56DAPK10.68062513
57KSR10.67949650
58MAP4K20.66894131
59NEK20.66165620
60EIF2AK10.62373145
61SIK20.59690306
62PLK40.58400167
63PRKCE0.57908366
64IRAK20.56636246
65FLT30.56004961
66RPS6KA60.55171548
67AKT30.53879098
68STK30.53625935
69RPS6KB20.53120927
70EIF2AK20.52401222
71PRKCI0.52006031
72BUB10.51211790
73CDK90.50502321
74CSNK1G30.49512467
75PAK30.49330600
76CSNK1A1L0.48783679
77LYN0.48428878
78RPS6KL10.47681450
79RPS6KC10.47681450
80PINK10.46284561
81CDK30.41940828
82MKNK10.41543406
83SIK30.40904574
84ATR0.40010391
85CSNK1G20.39259961
86TEC0.38139986
87YES10.37679195
88GRK70.37636279
89OBSCN0.36421696
90CSNK1A10.36301840
91CSF1R0.34274868
92EPHB20.33858718
93PRKCG0.33505221
94CASK0.33426336
95MAP2K10.31964551
96MAPKAPK50.30036033
97LATS10.29663613
98NME10.29455667
99RPS6KB10.29150802
100TTK0.28649095

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.28490405
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.14424814
3Oxidative phosphorylation_Homo sapiens_hsa001903.14203475
4Proteasome_Homo sapiens_hsa030503.10871083
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005343.07761813
6Ribosome_Homo sapiens_hsa030103.02585911
7Caffeine metabolism_Homo sapiens_hsa002322.67305332
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.56039092
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46621945
10Parkinsons disease_Homo sapiens_hsa050122.45267829
11Protein export_Homo sapiens_hsa030602.41564614
12Allograft rejection_Homo sapiens_hsa053302.38933828
13Autoimmune thyroid disease_Homo sapiens_hsa053202.37541461
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.35137102
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08791642
16Graft-versus-host disease_Homo sapiens_hsa053321.91710167
17Type I diabetes mellitus_Homo sapiens_hsa049401.83487011
18Huntingtons disease_Homo sapiens_hsa050161.82228758
19Alzheimers disease_Homo sapiens_hsa050101.79262442
20Cardiac muscle contraction_Homo sapiens_hsa042601.79147309
21RNA degradation_Homo sapiens_hsa030181.77870982
22Primary immunodeficiency_Homo sapiens_hsa053401.62897630
23Antigen processing and presentation_Homo sapiens_hsa046121.54467693
24RNA polymerase_Homo sapiens_hsa030201.53244061
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.51452978
26Basal transcription factors_Homo sapiens_hsa030221.51269882
27One carbon pool by folate_Homo sapiens_hsa006701.50958057
28Nitrogen metabolism_Homo sapiens_hsa009101.45863561
29Linoleic acid metabolism_Homo sapiens_hsa005911.37097330
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37026901
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.35794063
32Fanconi anemia pathway_Homo sapiens_hsa034601.32221837
33Phototransduction_Homo sapiens_hsa047441.28309895
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28007478
35RNA transport_Homo sapiens_hsa030131.27586802
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25330557
37Regulation of autophagy_Homo sapiens_hsa041401.23262983
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22047762
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14954068
40Tryptophan metabolism_Homo sapiens_hsa003801.08825919
41Propanoate metabolism_Homo sapiens_hsa006401.04277356
42Systemic lupus erythematosus_Homo sapiens_hsa053221.04190071
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.96601485
44Rheumatoid arthritis_Homo sapiens_hsa053230.88578422
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88538842
46Steroid biosynthesis_Homo sapiens_hsa001000.88194968
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87833328
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.86470846
49Olfactory transduction_Homo sapiens_hsa047400.83104505
50Nucleotide excision repair_Homo sapiens_hsa034200.78711301
51Vitamin B6 metabolism_Homo sapiens_hsa007500.78420021
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71255951
53Fat digestion and absorption_Homo sapiens_hsa049750.70624174
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69438874
55Base excision repair_Homo sapiens_hsa034100.68601341
56Pyrimidine metabolism_Homo sapiens_hsa002400.66574558
57Vitamin digestion and absorption_Homo sapiens_hsa049770.66561205
58Viral myocarditis_Homo sapiens_hsa054160.65392053
59Chemical carcinogenesis_Homo sapiens_hsa052040.63052805
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62422377
61Arachidonic acid metabolism_Homo sapiens_hsa005900.61509757
62Staphylococcus aureus infection_Homo sapiens_hsa051500.59408301
63Spliceosome_Homo sapiens_hsa030400.58556857
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58135326
65Sulfur metabolism_Homo sapiens_hsa009200.58013297
66Legionellosis_Homo sapiens_hsa051340.57408792
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57327928
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.56249464
69Purine metabolism_Homo sapiens_hsa002300.55497762
70Herpes simplex infection_Homo sapiens_hsa051680.55434248
71Hematopoietic cell lineage_Homo sapiens_hsa046400.55257543
72Metabolic pathways_Homo sapiens_hsa011000.54961381
73Collecting duct acid secretion_Homo sapiens_hsa049660.53489129
74Peroxisome_Homo sapiens_hsa041460.53416709
75Ether lipid metabolism_Homo sapiens_hsa005650.50091092
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.45893534
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44913623
78Ovarian steroidogenesis_Homo sapiens_hsa049130.43635042
79Measles_Homo sapiens_hsa051620.42898750
80Homologous recombination_Homo sapiens_hsa034400.42145349
81Basal cell carcinoma_Homo sapiens_hsa052170.42086345
82Glutathione metabolism_Homo sapiens_hsa004800.41987701
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36527016
84DNA replication_Homo sapiens_hsa030300.36284088
85Retinol metabolism_Homo sapiens_hsa008300.35371229
86Leishmaniasis_Homo sapiens_hsa051400.33208945
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31617326
88Mineral absorption_Homo sapiens_hsa049780.31422329
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31260879
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30056486
91Insulin secretion_Homo sapiens_hsa049110.27243801
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25851496
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.25095542
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24984376
95Butanoate metabolism_Homo sapiens_hsa006500.24146812
96Nicotine addiction_Homo sapiens_hsa050330.23087151
97Fatty acid degradation_Homo sapiens_hsa000710.22508525
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21366680
99Tuberculosis_Homo sapiens_hsa051520.20866054
100Epstein-Barr virus infection_Homo sapiens_hsa051690.20241062

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