ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of memory T cell differentiation (GO:0043380)	4.79818303
2	protein polyglutamylation (GO:0018095)	4.78312386
3	cellular ketone body metabolic process (GO:0046950)	4.57787766
4	cornea development in camera-type eye (GO:0061303)	4.49975534
5	behavioral response to nicotine (GO:0035095)	4.48596422
6	regulation of cilium movement (GO:0003352)	4.15069086
7	DNA deamination (GO:0045006)	4.11211628
8	ketone body metabolic process (GO:1902224)	4.02710237
9	positive regulation of cell fate commitment (GO:0010455)	3.73336416
10	somite development (GO:0061053)	3.71497913
11	epithelial cilium movement (GO:0003351)	3.58265036
12	piRNA metabolic process (GO:0034587)	3.44590902
13	sperm motility (GO:0030317)	3.43108656
14	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.32192339
15	ATP synthesis coupled proton transport (GO:0015986)	3.32192339
16	axoneme assembly (GO:0035082)	3.29846517
17	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.28232218
18	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.27534455
19	cilium morphogenesis (GO:0060271)	3.25010992
20	protein complex biogenesis (GO:0070271)	3.24535181
21	histone H2A acetylation (GO:0043968)	3.22995677
22	nonmotile primary cilium assembly (GO:0035058)	3.18981132
23	regulation of development, heterochronic (GO:0040034)	3.18276750
24	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.15262308
25	regulation of timing of cell differentiation (GO:0048505)	3.12436010
26	mannosylation (GO:0097502)	3.09761988
27	response to pheromone (GO:0019236)	3.08984879
28	estrogen biosynthetic process (GO:0006703)	3.07775582
29	DNA double-strand break processing (GO:0000729)	3.05151567
30	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.04148883
31	regulation of microtubule-based movement (GO:0060632)	3.01847814
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.01435913
33	NADH dehydrogenase complex assembly (GO:0010257)	3.01435913
34	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.01435913
35	axonemal dynein complex assembly (GO:0070286)	3.01410900
36	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.00689407
37	water-soluble vitamin biosynthetic process (GO:0042364)	2.99495394
38	L-methionine salvage (GO:0071267)	2.97361466
39	L-methionine biosynthetic process (GO:0071265)	2.97361466
40	amino acid salvage (GO:0043102)	2.97361466
41	positive regulation of defense response to virus by host (GO:0002230)	2.96980002
42	acrosome reaction (GO:0007340)	2.96075065
43	regulation of glucokinase activity (GO:0033131)	2.95810664
44	regulation of hexokinase activity (GO:1903299)	2.95810664
45	inositol phosphate catabolic process (GO:0071545)	2.93419596
46	RNA destabilization (GO:0050779)	2.91279297
47	cilium movement (GO:0003341)	2.89306703
48	signal peptide processing (GO:0006465)	2.87790058
49	intraciliary transport (GO:0042073)	2.87461240
50	phosphatidylethanolamine metabolic process (GO:0046337)	2.86430548
51	male meiosis (GO:0007140)	2.85241852
52	tryptophan catabolic process (GO:0006569)	2.84762556
53	indole-containing compound catabolic process (GO:0042436)	2.84762556
54	indolalkylamine catabolic process (GO:0046218)	2.84762556
55	multicellular organism reproduction (GO:0032504)	2.84179373
56	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83218047
57	spermatid development (GO:0007286)	2.82645791
58	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.80108740
59	regulation of feeding behavior (GO:0060259)	2.78088177
60	adenosine metabolic process (GO:0046085)	2.76995423
61	regulation of activation of Janus kinase activity (GO:0010533)	2.76817555
62	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.75806180
63	preassembly of GPI anchor in ER membrane (GO:0016254)	2.75398223
64	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.74785497
65	negative regulation of membrane potential (GO:0045837)	2.71257168
66	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.70547043
67	glycerophospholipid catabolic process (GO:0046475)	2.70295310
68	proteasome assembly (GO:0043248)	2.69188178
69	protein localization to cilium (GO:0061512)	2.69138147
70	fucose catabolic process (GO:0019317)	2.67073503
71	L-fucose metabolic process (GO:0042354)	2.67073503
72	L-fucose catabolic process (GO:0042355)	2.67073503
73	GPI anchor metabolic process (GO:0006505)	2.66773956
74	negative regulation of mast cell activation (GO:0033004)	2.65728314
75	ADP metabolic process (GO:0046031)	2.65074740
76	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.63565371
77	cilium organization (GO:0044782)	2.61784050
78	inositol phosphate dephosphorylation (GO:0046855)	2.61312266
79	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.61312266
80	resolution of meiotic recombination intermediates (GO:0000712)	2.61190357
81	indolalkylamine metabolic process (GO:0006586)	2.60698740
82	establishment of protein localization to Golgi (GO:0072600)	2.59641924
83	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.59389062
84	pituitary gland development (GO:0021983)	2.59267394
85	photoreceptor cell development (GO:0042461)	2.58725110
86	cilium assembly (GO:0042384)	2.57289984
87	sulfation (GO:0051923)	2.57191156
88	cytidine deamination (GO:0009972)	2.57038102
89	cytidine metabolic process (GO:0046087)	2.57038102
90	cytidine catabolic process (GO:0006216)	2.57038102
91	DNA methylation involved in gamete generation (GO:0043046)	2.55727177
92	gamma-aminobutyric acid transport (GO:0015812)	2.55067918
93	spermatid nucleus differentiation (GO:0007289)	2.54925536
94	magnesium ion transport (GO:0015693)	2.54641971
95	hair cycle (GO:0042633)	2.52076145
96	molting cycle (GO:0042303)	2.52076145
97	protein targeting to Golgi (GO:0000042)	2.51087305
98	platelet dense granule organization (GO:0060155)	2.50927944
99	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.50193091
100	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.50193091

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.49723204
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.04273177
3	VDR_22108803_ChIP-Seq_LS180_Human	2.70243387
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.56544341
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.53098569
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40190625
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.39036278
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37209255
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34535556
10	FUS_26573619_Chip-Seq_HEK293_Human	2.32401250
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.32348108
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.24108420
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.18012067
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.14176283
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07462575
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.99079577
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97874033
18	P300_19829295_ChIP-Seq_ESCs_Human	1.95763217
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.93677719
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.92968051
21	EWS_26573619_Chip-Seq_HEK293_Human	1.86125277
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.83544503
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.83544503
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.73975809
25	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.72819208
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72666096
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.61005632
28	GATA1_22025678_ChIP-Seq_K562_Human	1.60112111
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59782151
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59156021
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58426714
32	VDR_23849224_ChIP-Seq_CD4+_Human	1.57900833
33	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.56750499
34	NANOG_19829295_ChIP-Seq_ESCs_Human	1.51997505
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.51997505
36	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50569163
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50149105
38	ELK1_19687146_ChIP-ChIP_HELA_Human	1.49435920
39	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49183203
40	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.47044949
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.45982628
42	AR_25329375_ChIP-Seq_VCAP_Human	1.45407014
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45330885
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40023472
45	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.37696945
46	STAT3_23295773_ChIP-Seq_U87_Human	1.35680885
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.33596542
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31025343
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31025343
50	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.30485160
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29982744
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29661706
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29373963
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.29271455
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26611705
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.26346340
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24256556
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23638798
59	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22998978
60	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22632588
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.22096606
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20369440
63	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19471664
64	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18921231
65	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.18552710
66	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.18465050
67	NCOR_22424771_ChIP-Seq_293T_Human	1.17514477
68	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.17387659
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16739772
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.16669412
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.15341365
72	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15136225
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14887179
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.14222405
75	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13465868
76	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.13438028
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13361103
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.13256348
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13050436
80	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12388446
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.12094344
82	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11146539
83	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11078249
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10617136
85	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09999716
86	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09963791
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05240723
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04392663
89	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02390486
90	AR_20517297_ChIP-Seq_VCAP_Human	1.02140286
91	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02093452
92	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.02017890
93	TCF4_23295773_ChIP-Seq_U87_Human	1.01197066
94	GATA3_26560356_Chip-Seq_TH2_Human	1.00911003
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00885739
96	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99129728
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98446666
98	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98256058
99	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98256058
100	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98139004

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.57364342
2	MP0006072_abnormal_retinal_apoptosis	3.04526741
3	MP0008877_abnormal_DNA_methylation	2.99922752
4	MP0006292_abnormal_olfactory_placode	2.94884922
5	MP0005084_abnormal_gallbladder_morpholo	2.51174125
6	MP0002638_abnormal_pupillary_reflex	2.40975309
7	MP0005410_abnormal_fertilization	2.39182371
8	MP0008789_abnormal_olfactory_epithelium	2.27189561
9	MP0001984_abnormal_olfaction	2.26906979
10	MP0000372_irregular_coat_pigmentation	2.20056392
11	MP0002938_white_spotting	2.10156959
12	MP0001968_abnormal_touch/_nociception	2.09413106
13	MP0003787_abnormal_imprinting	2.08961326
14	MP0001529_abnormal_vocalization	2.04213220
15	MP0005645_abnormal_hypothalamus_physiol	1.98604225
16	MP0005253_abnormal_eye_physiology	1.98336615
17	MP0004147_increased_porphyrin_level	1.97937112
18	MP0005551_abnormal_eye_electrophysiolog	1.96256156
19	MP0002138_abnormal_hepatobiliary_system	1.90079316
20	MP0003880_abnormal_central_pattern	1.88632496
21	MP0002837_dystrophic_cardiac_calcinosis	1.83158869
22	MP0002102_abnormal_ear_morphology	1.79480474
23	MP0002736_abnormal_nociception_after	1.75424661
24	MP0005499_abnormal_olfactory_system	1.74630132
25	MP0005394_taste/olfaction_phenotype	1.74630132
26	MP0009745_abnormal_behavioral_response	1.69336621
27	MP0009046_muscle_twitch	1.68903868
28	MP0004142_abnormal_muscle_tone	1.67067084
29	MP0005646_abnormal_pituitary_gland	1.65121323
30	MP0002876_abnormal_thyroid_physiology	1.64594433
31	MP0003011_delayed_dark_adaptation	1.45920102
32	MP0006276_abnormal_autonomic_nervous	1.44796623
33	MP0002272_abnormal_nervous_system	1.44546138
34	MP0002822_catalepsy	1.43892472
35	MP0001986_abnormal_taste_sensitivity	1.43661172
36	MP0002653_abnormal_ependyma_morphology	1.43107889
37	MP0001764_abnormal_homeostasis	1.42637290
38	MP0003698_abnormal_male_reproductive	1.38420281
39	MP0002735_abnormal_chemical_nociception	1.37452609
40	MP0010386_abnormal_urinary_bladder	1.33532695
41	MP0000631_abnormal_neuroendocrine_gland	1.31102026
42	MP0004885_abnormal_endolymph	1.30796665
43	MP0001929_abnormal_gametogenesis	1.29980425
44	MP0003283_abnormal_digestive_organ	1.28488694
45	MP0001486_abnormal_startle_reflex	1.28356908
46	MP0008875_abnormal_xenobiotic_pharmacok	1.25862617
47	MP0008995_early_reproductive_senescence	1.25259502
48	MP0008872_abnormal_physiological_respon	1.23578855
49	MP0004133_heterotaxia	1.21068534
50	MP0003806_abnormal_nucleotide_metabolis	1.20125418
51	MP0001970_abnormal_pain_threshold	1.18737599
52	MP0002160_abnormal_reproductive_system	1.14875614
53	MP0005075_abnormal_melanosome_morpholog	1.14332204
54	MP0002064_seizures	1.14314632
55	MP0001944_abnormal_pancreas_morphology	1.10706977
56	MP0002572_abnormal_emotion/affect_behav	1.10592893
57	MP0001440_abnormal_grooming_behavior	1.09746350
58	MP0000427_abnormal_hair_cycle	1.07361578
59	MP0002733_abnormal_thermal_nociception	1.06603272
60	MP0001501_abnormal_sleep_pattern	1.05826341
61	MP0002557_abnormal_social/conspecific_i	1.04195841
62	MP0000516_abnormal_urinary_system	1.03241871
63	MP0005367_renal/urinary_system_phenotyp	1.03241871
64	MP0005389_reproductive_system_phenotype	1.01186929
65	MP0003252_abnormal_bile_duct	1.00438255
66	MP0002928_abnormal_bile_duct	1.00158709
67	MP0002693_abnormal_pancreas_physiology	0.99139987
68	MP0001919_abnormal_reproductive_system	0.97546316
69	MP0003635_abnormal_synaptic_transmissio	0.95910145
70	MP0000613_abnormal_salivary_gland	0.93238298
71	MP0001485_abnormal_pinna_reflex	0.91772583
72	MP0005332_abnormal_amino_acid	0.91451665
73	MP0002067_abnormal_sensory_capabilities	0.90067014
74	MP0008058_abnormal_DNA_repair	0.88709947
75	MP0001905_abnormal_dopamine_level	0.87227665
76	MP0001765_abnormal_ion_homeostasis	0.84295250
77	MP0009697_abnormal_copulation	0.83454519
78	MP0002282_abnormal_trachea_morphology	0.82578151
79	MP0002751_abnormal_autonomic_nervous	0.82254082
80	MP0005085_abnormal_gallbladder_physiolo	0.82167931
81	MP0001502_abnormal_circadian_rhythm	0.81876094
82	MP0003718_maternal_effect	0.81245887
83	MP0000653_abnormal_sex_gland	0.81117231
84	MP0000013_abnormal_adipose_tissue	0.80467039
85	MP0002063_abnormal_learning/memory/cond	0.79447525
86	MP0005636_abnormal_mineral_homeostasis	0.79311703
87	MP0005379_endocrine/exocrine_gland_phen	0.78742354
88	MP0001188_hyperpigmentation	0.78347130
89	MP0001963_abnormal_hearing_physiology	0.78121303
90	MP0002734_abnormal_mechanical_nocicepti	0.78062831
91	MP0005195_abnormal_posterior_eye	0.77960206
92	MP0002210_abnormal_sex_determination	0.77160971
93	MP0001145_abnormal_male_reproductive	0.77133926
94	MP0005448_abnormal_energy_balance	0.76557664
95	MP0010329_abnormal_lipoprotein_level	0.74460853
96	MP0004924_abnormal_behavior	0.74388537
97	MP0005386_behavior/neurological_phenoty	0.74388537
98	MP0003646_muscle_fatigue	0.73675439
99	MP0005365_abnormal_bile_salt	0.72927177
100	MP0000026_abnormal_inner_ear	0.72832047

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.79252388
2	True hermaphroditism (HP:0010459)	3.51638578
3	Pancreatic fibrosis (HP:0100732)	3.39028048
4	Hypothermia (HP:0002045)	3.36474520
5	3-Methylglutaconic aciduria (HP:0003535)	3.32149763
6	Abnormality of midbrain morphology (HP:0002418)	3.30661757
7	Molar tooth sign on MRI (HP:0002419)	3.30661757
8	Nephronophthisis (HP:0000090)	3.29981289
9	Methylmalonic acidemia (HP:0002912)	3.18505663
10	Medial flaring of the eyebrow (HP:0010747)	3.13137169
11	Hypoplasia of the fovea (HP:0007750)	3.06737754
12	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.06737754
13	Absent/shortened dynein arms (HP:0200106)	2.94998897
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.94998897
15	Congenital stationary night blindness (HP:0007642)	2.94231956
16	Abnormality of the renal cortex (HP:0011035)	2.87925398
17	Acute necrotizing encephalopathy (HP:0006965)	2.83320792
18	Generalized aminoaciduria (HP:0002909)	2.74373151
19	Renal cortical cysts (HP:0000803)	2.73722142
20	Mitochondrial inheritance (HP:0001427)	2.73242387
21	Hepatic necrosis (HP:0002605)	2.72267291
22	Gait imbalance (HP:0002141)	2.71227603
23	Progressive macrocephaly (HP:0004481)	2.70237241
24	Methylmalonic aciduria (HP:0012120)	2.67327513
25	Hepatocellular necrosis (HP:0001404)	2.64302772
26	Abnormality of the renal medulla (HP:0100957)	2.63241188
27	Ketoacidosis (HP:0001993)	2.62191728
28	Abnormality of the fovea (HP:0000493)	2.61975570
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.59574947
30	Abolished electroretinogram (ERG) (HP:0000550)	2.58307794
31	Abnormal respiratory epithelium morphology (HP:0012253)	2.56657389
32	Abnormal respiratory motile cilium morphology (HP:0005938)	2.56657389
33	Congenital primary aphakia (HP:0007707)	2.55953869
34	Pendular nystagmus (HP:0012043)	2.47553168
35	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.45709284
36	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.45709284
37	Attenuation of retinal blood vessels (HP:0007843)	2.41299983
38	Abnormality of vitamin B metabolism (HP:0004340)	2.40870578
39	Chronic hepatic failure (HP:0100626)	2.40109401
40	Ketosis (HP:0001946)	2.37551139
41	Abnormal ciliary motility (HP:0012262)	2.37184114
42	Optic nerve hypoplasia (HP:0000609)	2.36816389
43	Increased CSF lactate (HP:0002490)	2.29613782
44	Male pseudohermaphroditism (HP:0000037)	2.23558258
45	Acute encephalopathy (HP:0006846)	2.23491940
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.19949558
47	Abnormal rod and cone electroretinograms (HP:0008323)	2.19048939
48	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.15882342
49	Abnormality of the pancreatic islet cells (HP:0006476)	2.13907138
50	Abnormality of endocrine pancreas physiology (HP:0012093)	2.13907138
51	Hyperventilation (HP:0002883)	2.13904196
52	Abnormal respiratory motile cilium physiology (HP:0012261)	2.13362244
53	Type II lissencephaly (HP:0007260)	2.09441195
54	Thyroiditis (HP:0100646)	2.09395971
55	Cerebral edema (HP:0002181)	2.05517814
56	Nephrogenic diabetes insipidus (HP:0009806)	2.05423464
57	Hypoglycemic coma (HP:0001325)	2.04271089
58	Optic disc pallor (HP:0000543)	2.03698128
59	Sclerocornea (HP:0000647)	2.01701034
60	Pancreatic islet-cell hyperplasia (HP:0004510)	2.01644554
61	Aplasia/hypoplasia of the uterus (HP:0008684)	1.99764232
62	Polydipsia (HP:0001959)	1.99132842
63	Abnormal drinking behavior (HP:0030082)	1.99132842
64	Cystic liver disease (HP:0006706)	1.97357604
65	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.97116865
66	Rhinitis (HP:0012384)	1.95625113
67	Glycosuria (HP:0003076)	1.93163253
68	Abnormality of urine glucose concentration (HP:0011016)	1.93163253
69	Genital tract atresia (HP:0001827)	1.92984741
70	Furrowed tongue (HP:0000221)	1.92883954
71	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.91716774
72	Intestinal atresia (HP:0011100)	1.91045669
73	Hemiparesis (HP:0001269)	1.90587323
74	Vaginal atresia (HP:0000148)	1.90058226
75	Polyphagia (HP:0002591)	1.89383897
76	Hypoplasia of the uterus (HP:0000013)	1.88256532
77	Decreased central vision (HP:0007663)	1.87244919
78	Anencephaly (HP:0002323)	1.87158591
79	Hyperinsulinemic hypoglycemia (HP:0000825)	1.86602221
80	Broad-based gait (HP:0002136)	1.86262847
81	Abnormality of macular pigmentation (HP:0008002)	1.86142990
82	Thyroid-stimulating hormone excess (HP:0002925)	1.84567021
83	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.84416251
84	Dicarboxylic aciduria (HP:0003215)	1.84416251
85	Congenital hepatic fibrosis (HP:0002612)	1.81579320
86	Keratoconus (HP:0000563)	1.80991320
87	Increased corneal curvature (HP:0100692)	1.80991320
88	Optic neuritis (HP:0100653)	1.78072983
89	Retrobulbar optic neuritis (HP:0100654)	1.78072983
90	Large for gestational age (HP:0001520)	1.77799588
91	Keratitis (HP:0000491)	1.77155050
92	Type I transferrin isoform profile (HP:0003642)	1.74916170
93	Postaxial hand polydactyly (HP:0001162)	1.74888438
94	Median cleft lip (HP:0000161)	1.69853491
95	Inability to walk (HP:0002540)	1.68066156
96	Increased serum lactate (HP:0002151)	1.67523751
97	Poor head control (HP:0002421)	1.66525316
98	Abnormality of DNA repair (HP:0003254)	1.65673846
99	Hypomagnesemia (HP:0002917)	1.64365304
100	Optic nerve coloboma (HP:0000588)	1.64055962

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.93062860
2	MAP4K2	4.10588795
3	INSRR	3.04530071
4	ADRBK2	2.88757811
5	ZAK	2.42731369
6	BCKDK	2.37456808
7	PINK1	2.30489057
8	MAPK13	2.15628164
9	TLK1	2.11125501
10	FGFR2	2.08342982
11	NUAK1	2.02441077
12	TAOK3	1.96142457
13	EIF2AK3	1.94905207
14	CASK	1.92858433
15	WNK3	1.89323858
16	GRK1	1.88183896
17	MAP3K4	1.72484122
18	TXK	1.70475394
19	EPHA3	1.61570119
20	STK38L	1.58744365
21	TRIM28	1.55666176
22	DYRK2	1.39607490
23	VRK1	1.37431854
24	MAP2K7	1.29939800
25	STK16	1.28335173
26	PHKG1	1.25477239
27	PHKG2	1.25477239
28	RPS6KA5	1.22627433
29	PTK2B	1.20737306
30	PAK3	1.19119935
31	PLK2	1.14311623
32	WNK4	1.13268251
33	MAPK15	1.07510045
34	IKBKB	0.97592689
35	VRK2	0.96537247
36	PRKCE	0.96507864
37	NTRK3	0.96008873
38	BMPR1B	0.93790901
39	TNIK	0.92807461
40	MARK1	0.92456465
41	CSNK1G3	0.92398944
42	CSNK1G2	0.92208314
43	TSSK6	0.91333084
44	MUSK	0.90120762
45	EPHA4	0.89856701
46	RPS6KA4	0.88953684
47	PLK3	0.88493998
48	CSNK1G1	0.88437813
49	CDK19	0.87713640
50	NLK	0.87473232
51	BCR	0.87182414
52	ERBB3	0.83987944
53	IRAK1	0.81022860
54	BRSK2	0.80199395
55	PRKCG	0.78197773
56	CSNK1A1L	0.76617027
57	TIE1	0.75910912
58	PLK4	0.72521915
59	HIPK2	0.71590431
60	OXSR1	0.70414277
61	PKN1	0.69344569
62	PASK	0.62101204
63	DAPK2	0.61600914
64	MARK3	0.60179975
65	KDR	0.60095700
66	MAPKAPK5	0.59628125
67	PNCK	0.58278594
68	CDK3	0.55304075
69	BRD4	0.53532310
70	PRKCQ	0.51266127
71	STK39	0.51085056
72	MAP3K9	0.47948895
73	PRKCI	0.47247919
74	NTRK2	0.46763918
75	MST4	0.46717991
76	OBSCN	0.46703690
77	CSNK1A1	0.45726891
78	CHUK	0.43684470
79	PIM2	0.43491276
80	FER	0.42657418
81	PIK3CG	0.42463290
82	ADRBK1	0.42126712
83	KIT	0.39263123
84	DYRK3	0.38390366
85	GRK7	0.37774251
86	PRKACA	0.37420622
87	SGK223	0.35509295
88	SGK494	0.35509295
89	TEC	0.35360359
90	IKBKE	0.33428612
91	MAP3K12	0.32129797
92	ACVR1B	0.32013892
93	RAF1	0.31149588
94	MYLK	0.30127056
95	CAMKK2	0.29098223
96	GRK5	0.26547688
97	STK3	0.26279349
98	CDK8	0.24932584
99	SGK2	0.24322567
100	ITK	0.23893278

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.43828659
2	Protein export_Homo sapiens_hsa03060	3.30884854
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.08345028
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.07852192
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.69728048
6	Butanoate metabolism_Homo sapiens_hsa00650	2.52132911
7	Parkinsons disease_Homo sapiens_hsa05012	2.27927422
8	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.24813098
9	Phototransduction_Homo sapiens_hsa04744	2.19278276
10	Nicotine addiction_Homo sapiens_hsa05033	2.08242322
11	Propanoate metabolism_Homo sapiens_hsa00640	2.08111998
12	Sulfur metabolism_Homo sapiens_hsa00920	1.85002821
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.79013026
14	Proteasome_Homo sapiens_hsa03050	1.57560018
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56555935
16	Alzheimers disease_Homo sapiens_hsa05010	1.53621617
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.53369725
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.52378250
19	Regulation of autophagy_Homo sapiens_hsa04140	1.50431309
20	RNA polymerase_Homo sapiens_hsa03020	1.50041780
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48670079
22	Huntingtons disease_Homo sapiens_hsa05016	1.45127723
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.43722072
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.40313684
25	RNA degradation_Homo sapiens_hsa03018	1.38659609
26	Type I diabetes mellitus_Homo sapiens_hsa04940	1.33448884
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.29362650
28	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.25908917
29	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.25318601
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.24017175
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.23674172
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.22453536
33	Taste transduction_Homo sapiens_hsa04742	1.21081114
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19788194
35	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.19399653
36	Collecting duct acid secretion_Homo sapiens_hsa04966	1.17535276
37	Peroxisome_Homo sapiens_hsa04146	1.16338537
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.15465708
39	Retinol metabolism_Homo sapiens_hsa00830	1.14989861
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13664733
41	Caffeine metabolism_Homo sapiens_hsa00232	1.10419432
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10385185
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.09775134
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09453063
45	Basal transcription factors_Homo sapiens_hsa03022	1.07615788
46	Asthma_Homo sapiens_hsa05310	1.01816636
47	Cardiac muscle contraction_Homo sapiens_hsa04260	1.01810685
48	GABAergic synapse_Homo sapiens_hsa04727	1.00751413
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.98158699
50	Olfactory transduction_Homo sapiens_hsa04740	0.97192327
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.95626524
52	Insulin secretion_Homo sapiens_hsa04911	0.94122505
53	Graft-versus-host disease_Homo sapiens_hsa05332	0.89856179
54	Homologous recombination_Homo sapiens_hsa03440	0.89370030
55	Circadian rhythm_Homo sapiens_hsa04710	0.88730588
56	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.87626022
57	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.87332596
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.86232791
59	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.82392271
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75808532
61	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.74942695
62	Circadian entrainment_Homo sapiens_hsa04713	0.74022052
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71681830
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.71428108
65	Metabolic pathways_Homo sapiens_hsa01100	0.71343563
66	Purine metabolism_Homo sapiens_hsa00230	0.67293280
67	Fatty acid elongation_Homo sapiens_hsa00062	0.67093238
68	Ether lipid metabolism_Homo sapiens_hsa00565	0.67034732
69	Allograft rejection_Homo sapiens_hsa05330	0.66941883
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.65647249
71	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.65131932
72	Morphine addiction_Homo sapiens_hsa05032	0.64656165
73	Serotonergic synapse_Homo sapiens_hsa04726	0.63949613
74	Folate biosynthesis_Homo sapiens_hsa00790	0.62780749
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61648547
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61020994
77	Cocaine addiction_Homo sapiens_hsa05030	0.60958475
78	One carbon pool by folate_Homo sapiens_hsa00670	0.59806668
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.58836917
80	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.57811467
81	Alcoholism_Homo sapiens_hsa05034	0.56543599
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56215408
83	Amphetamine addiction_Homo sapiens_hsa05031	0.55436200
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.54931040
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.52729524
86	Antigen processing and presentation_Homo sapiens_hsa04612	0.49862589
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.48400147
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46879054
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46853731
90	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45185213
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44701878
92	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.44560049
93	Fat digestion and absorption_Homo sapiens_hsa04975	0.42311903
94	ABC transporters_Homo sapiens_hsa02010	0.39077423
95	Nucleotide excision repair_Homo sapiens_hsa03420	0.37989244
96	Fatty acid degradation_Homo sapiens_hsa00071	0.36387759
97	Dopaminergic synapse_Homo sapiens_hsa04728	0.35931947
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35926955
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35420805
100	Sulfur relay system_Homo sapiens_hsa04122	0.33793160

SEPT7P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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