SEPT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.56646012
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.93852851
3locomotory exploration behavior (GO:0035641)4.89748512
4axon ensheathment in central nervous system (GO:0032291)4.62849115
5central nervous system myelination (GO:0022010)4.62849115
6neuronal action potential propagation (GO:0019227)4.53653285
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.53162993
8synaptic vesicle exocytosis (GO:0016079)4.52240389
9glutamate secretion (GO:0014047)4.47588070
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.45575011
11regulation of synaptic vesicle exocytosis (GO:2000300)4.34998047
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.16368890
13vocalization behavior (GO:0071625)4.15046072
14cellular potassium ion homeostasis (GO:0030007)4.08921139
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.07779725
16L-amino acid import (GO:0043092)4.04673646
17ionotropic glutamate receptor signaling pathway (GO:0035235)3.98610393
18regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.97686912
19sodium ion export (GO:0071436)3.96173398
20regulation of neuronal synaptic plasticity (GO:0048168)3.84345901
21regulation of synaptic vesicle transport (GO:1902803)3.79881462
22regulation of glutamate receptor signaling pathway (GO:1900449)3.70372076
23dendritic spine morphogenesis (GO:0060997)3.69008793
24postsynaptic membrane organization (GO:0001941)3.66331985
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.66129124
26membrane assembly (GO:0071709)3.59388481
27layer formation in cerebral cortex (GO:0021819)3.58484122
28glutamate receptor signaling pathway (GO:0007215)3.54772120
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52200609
30glycine transport (GO:0015816)3.51739417
31neurotransmitter secretion (GO:0007269)3.48725632
32protein localization to synapse (GO:0035418)3.47798832
33exploration behavior (GO:0035640)3.47072049
34neuron cell-cell adhesion (GO:0007158)3.46888562
35regulation of synapse structural plasticity (GO:0051823)3.45180205
36synaptic transmission, glutamatergic (GO:0035249)3.41750111
37cellular sodium ion homeostasis (GO:0006883)3.40482220
38potassium ion import (GO:0010107)3.29535449
39neuromuscular process controlling balance (GO:0050885)3.29433760
40positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29407946
41long-term memory (GO:0007616)3.27924510
42cerebellar granule cell differentiation (GO:0021707)3.27817973
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.26392930
44neuron-neuron synaptic transmission (GO:0007270)3.25881745
45amino acid import (GO:0043090)3.24499145
46gamma-aminobutyric acid transport (GO:0015812)3.22249000
47cerebellar Purkinje cell differentiation (GO:0021702)3.22046957
48negative regulation of dendrite morphogenesis (GO:0050774)3.18166491
49positive regulation of dendritic spine development (GO:0060999)3.17526090
50activation of protein kinase A activity (GO:0034199)3.13842303
51adult walking behavior (GO:0007628)3.13703957
52neuromuscular process controlling posture (GO:0050884)3.12624653
53neuron recognition (GO:0008038)3.11769027
54positive regulation of dendritic spine morphogenesis (GO:0061003)3.11311038
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.11014318
56cytoskeletal anchoring at plasma membrane (GO:0007016)3.10606965
57regulation of postsynaptic membrane potential (GO:0060078)3.08435673
58regulation of synaptic plasticity (GO:0048167)3.08323596
59regulation of voltage-gated calcium channel activity (GO:1901385)3.05753015
60long-term synaptic potentiation (GO:0060291)3.05338689
61axonal fasciculation (GO:0007413)3.02704591
62regulation of neurotransmitter secretion (GO:0046928)3.02269214
63neurotransmitter transport (GO:0006836)3.01791333
64negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01496520
65dendrite morphogenesis (GO:0048813)3.00483452
66plasma membrane repair (GO:0001778)3.00075751
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99903863
68myelin maintenance (GO:0043217)2.94903250
69regulation of dendritic spine morphogenesis (GO:0061001)2.93917932
70potassium ion homeostasis (GO:0055075)2.93119972
71cell communication involved in cardiac conduction (GO:0086065)2.92511036
72neurotransmitter-gated ion channel clustering (GO:0072578)2.92172718
73synaptic vesicle endocytosis (GO:0048488)2.91983258
74negative regulation of neurotransmitter transport (GO:0051589)2.90280344
75astrocyte development (GO:0014002)2.89401030
76myelination (GO:0042552)2.89192411
77axon ensheathment (GO:0008366)2.88781752
78ensheathment of neurons (GO:0007272)2.88781752
79positive regulation of membrane potential (GO:0045838)2.88760889
80regulation of neurotransmitter transport (GO:0051588)2.86549587
81negative regulation of protein localization to cell surface (GO:2000009)2.85362639
82mating behavior (GO:0007617)2.84623658
83regulation of synapse maturation (GO:0090128)2.84360817
84transmission of nerve impulse (GO:0019226)2.84080007
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.82240318
86neuronal ion channel clustering (GO:0045161)2.79364876
87response to methylmercury (GO:0051597)2.78997221
88dendritic spine organization (GO:0097061)2.78174354
89cell communication by electrical coupling (GO:0010644)2.77378831
90long-chain fatty acid biosynthetic process (GO:0042759)2.77323016
91nerve growth factor signaling pathway (GO:0038180)2.77251409
92presynaptic membrane organization (GO:0097090)2.76488238
93cerebellar Purkinje cell layer development (GO:0021680)2.75525929
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.75009259
95regulation of ARF protein signal transduction (GO:0032012)2.74968209
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74210829
97regulation of neurotransmitter levels (GO:0001505)2.73914069
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.73530612
99negative regulation of potassium ion transmembrane transport (GO:1901380)2.72600107
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72591921
101membrane depolarization (GO:0051899)2.72526999
102auditory behavior (GO:0031223)2.71788655
103vesicle transport along microtubule (GO:0047496)2.71654138
104membrane hyperpolarization (GO:0060081)2.70935288
105positive regulation of synapse maturation (GO:0090129)2.70824694
106proline transport (GO:0015824)2.70817439
107neuromuscular process (GO:0050905)2.70186311
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.69846671
109negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69123997
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.68494266
111neurotransmitter uptake (GO:0001504)2.68024714
112acidic amino acid transport (GO:0015800)2.67363852
113membrane depolarization during action potential (GO:0086010)2.65851155
114regulation of synaptic transmission (GO:0050804)2.62758764
115G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.62245704
116regulation of p38MAPK cascade (GO:1900744)2.56177050
117positive regulation of dendrite development (GO:1900006)2.55668462
118regulation of dendritic spine development (GO:0060998)2.53871854
119presynaptic membrane assembly (GO:0097105)2.51140581
120regulation of vesicle fusion (GO:0031338)2.49102363
121clathrin coat assembly (GO:0048268)2.49044290
122substantia nigra development (GO:0021762)2.48247946
123negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.46794356
124negative regulation of cell size (GO:0045792)2.45819623
125regulation of early endosome to late endosome transport (GO:2000641)2.42073591
126cell migration in hindbrain (GO:0021535)2.40963164
127response to gravity (GO:0009629)2.40490164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.84563733
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09340559
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02580910
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88811632
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82756034
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82756034
7GBX2_23144817_ChIP-Seq_PC3_Human2.81953123
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60552606
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57640147
10DROSHA_22980978_ChIP-Seq_HELA_Human2.55348175
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55238635
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54668062
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52913372
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47700469
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.37721964
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.33860425
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.29457499
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.18799595
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16545689
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.15860607
21REST_21632747_ChIP-Seq_MESCs_Mouse2.02751686
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98245907
23AR_21572438_ChIP-Seq_LNCaP_Human1.95501004
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93696622
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.84263891
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83870888
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81179369
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80025581
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78627175
30REST_18959480_ChIP-ChIP_MESCs_Mouse1.70262138
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66202322
32CLOCK_20551151_ChIP-Seq_293T_Human1.64464326
33LXR_22292898_ChIP-Seq_THP-1_Human1.64053735
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.58668054
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54386071
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53326960
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51011226
38WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43133733
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41131114
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40303830
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39597271
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37743262
43TP53_16413492_ChIP-PET_HCT116_Human1.37229794
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35902267
45KDM2B_26808549_Chip-Seq_K562_Human1.33925345
46RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33241466
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31939642
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31673033
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30867018
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30628788
51SMAD4_21799915_ChIP-Seq_A2780_Human1.30258630
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.28865685
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.28251083
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27428026
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27056652
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26391844
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26109518
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25452881
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24563131
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24512759
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.23553571
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22314103
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22022425
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21555862
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19972117
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18951648
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18391150
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17083347
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16848347
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.15120380
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.14492573
72RACK7_27058665_Chip-Seq_MCF-7_Human1.14236950
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13996827
74CTCF_27219007_Chip-Seq_Bcells_Human1.12925068
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.12870372
76RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12843274
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.12430251
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11337171
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.10950540
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.10705088
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10565216
82AR_19668381_ChIP-Seq_PC3_Human1.10316374
83ZNF274_21170338_ChIP-Seq_K562_Hela1.09723805
84EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09592719
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09576897
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09347196
87CREB1_26743006_Chip-Seq_LNCaP_Human1.09022591
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08256466
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07708765
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07509984
91AHR_22903824_ChIP-Seq_MCF-7_Human1.07034962
92STAT3_23295773_ChIP-Seq_U87_Human1.06402694
93TP53_23651856_ChIP-Seq_MEFs_Mouse1.06354939
94GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.04547149
95KDM2B_26808549_Chip-Seq_DND41_Human1.03639151
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.03436641
97RXR_22108803_ChIP-Seq_LS180_Human1.02620101
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.01541621
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00219391
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98652241
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97910256
102AR_25329375_ChIP-Seq_VCAP_Human0.97578007
103TP53_20018659_ChIP-ChIP_R1E_Mouse0.97270351
104TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97226281
105SMC4_20622854_ChIP-Seq_HELA_Human0.97196143
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97063768
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97063768
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.96762394
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.96762394
110EGR1_19374776_ChIP-ChIP_THP-1_Human0.96448245
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95826468
112MYC_19915707_ChIP-ChIP_AK7_Human0.94996513
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.94949702
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94699220
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94486358
116TAF15_26573619_Chip-Seq_HEK293_Human0.94411711
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93992057
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93789474
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93630223
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91914290
121TCF4_23295773_ChIP-Seq_U87_Human0.91615032
122P300_19829295_ChIP-Seq_ESCs_Human0.91243358
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.91114493
124CBX2_27304074_Chip-Seq_ESCs_Mouse0.90145983
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90070701
126AR_21909140_ChIP-Seq_LNCAP_Human0.89679304
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.89622856
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.89206016
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88880917
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88828287
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.88594734
132TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88501295
133TP53_18474530_ChIP-ChIP_U2OS_Human0.88360898
134NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87233290
135ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87027326
136KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86706019
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86441808
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86037552
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86020795
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85586077
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.85453662
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.85120184
143ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85057867
144CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84292769
145SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84267657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.96910778
2MP0003880_abnormal_central_pattern4.25323906
3MP0003635_abnormal_synaptic_transmissio3.71536246
4MP0004270_analgesia3.36240727
5MP0002064_seizures3.03007457
6MP0009046_muscle_twitch3.01813342
7MP0003705_abnormal_hypodermis_morpholog2.92250705
8MP0009745_abnormal_behavioral_response2.90474854
9MP0002063_abnormal_learning/memory/cond2.79127131
10MP0002272_abnormal_nervous_system2.68022325
11MP0003329_amyloid_beta_deposits2.50895278
12MP0001486_abnormal_startle_reflex2.43361571
13MP0000920_abnormal_myelination2.43090761
14MP0001968_abnormal_touch/_nociception2.38070106
15MP0002572_abnormal_emotion/affect_behav2.33128454
16MP0005423_abnormal_somatic_nervous2.32344220
17MP0008569_lethality_at_weaning2.29162371
18MP0002734_abnormal_mechanical_nocicepti2.23449574
19MP0004885_abnormal_endolymph1.90121509
20MP0005623_abnormal_meninges_morphology1.88562146
21MP0001501_abnormal_sleep_pattern1.83171634
22MP0001440_abnormal_grooming_behavior1.81683844
23MP0002736_abnormal_nociception_after1.80172555
24MP0002067_abnormal_sensory_capabilities1.74517402
25MP0004858_abnormal_nervous_system1.73299938
26MP0009780_abnormal_chondrocyte_physiolo1.72989825
27MP0001970_abnormal_pain_threshold1.72025730
28MP0003690_abnormal_glial_cell1.71049393
29MP0000751_myopathy1.66581275
30MP0002822_catalepsy1.65319651
31MP0000778_abnormal_nervous_system1.63849966
32MP0003633_abnormal_nervous_system1.62123160
33MP0000579_abnormal_nail_morphology1.60983905
34MP0002733_abnormal_thermal_nociception1.60481185
35MP0002735_abnormal_chemical_nociception1.53781824
36MP0000566_synostosis1.51363809
37MP0004811_abnormal_neuron_physiology1.50851810
38MP0004145_abnormal_muscle_electrophysio1.49717886
39MP0001346_abnormal_lacrimal_gland1.49424805
40MP0000955_abnormal_spinal_cord1.48193387
41MP0008438_abnormal_cutaneous_collagen1.46119829
42MP0003631_nervous_system_phenotype1.45111423
43MP0003634_abnormal_glial_cell1.45017251
44MP0005386_behavior/neurological_phenoty1.41298169
45MP0004924_abnormal_behavior1.41298169
46MP0002066_abnormal_motor_capabilities/c1.38060760
47MP0002184_abnormal_innervation1.37267202
48MP0004142_abnormal_muscle_tone1.35117087
49MP0002882_abnormal_neuron_morphology1.34678233
50MP0002249_abnormal_larynx_morphology1.30375902
51MP0004272_abnormal_basement_membrane1.30304503
52MP0002557_abnormal_social/conspecific_i1.30267262
53MP0000013_abnormal_adipose_tissue1.28880134
54MP0005171_absent_coat_pigmentation1.28172310
55MP0003632_abnormal_nervous_system1.28092134
56MP0001348_abnormal_lacrimal_gland1.27976633
57MP0005409_darkened_coat_color1.27352568
58MP0004742_abnormal_vestibular_system1.25308761
59MP0003123_paternal_imprinting1.23689532
60MP0000604_amyloidosis1.17521638
61MP0001299_abnormal_eye_distance/1.16103080
62MP0000747_muscle_weakness1.12584864
63MP0002089_abnormal_postnatal_growth/wei1.12021179
64MP0010234_abnormal_vibrissa_follicle1.11600512
65MP0002909_abnormal_adrenal_gland1.09691753
66MP0001177_atelectasis1.09517181
67MP0002229_neurodegeneration1.08237117
68MP0003950_abnormal_plasma_membrane1.06037231
69MP0005275_abnormal_skin_tensile1.05319300
70MP0001905_abnormal_dopamine_level1.04529092
71MP0003879_abnormal_hair_cell1.02015042
72MP0002152_abnormal_brain_morphology1.01706103
73MP0003075_altered_response_to0.99976914
74MP0003122_maternal_imprinting0.98737134
75MP0004215_abnormal_myocardial_fiber0.97736070
76MP0003385_abnormal_body_wall0.95596964
77MP0003566_abnormal_cell_adhesion0.92273991
78MP0001502_abnormal_circadian_rhythm0.92086119
79MP0005167_abnormal_blood-brain_barrier0.90299056
80MP0001958_emphysema0.89388668
81MP0001529_abnormal_vocalization0.89373453
82MP0003283_abnormal_digestive_organ0.89003312
83MP0005646_abnormal_pituitary_gland0.87977443
84MP0000003_abnormal_adipose_tissue0.87644744
85MP0000537_abnormal_urethra_morphology0.86894898
86MP0000462_abnormal_digestive_system0.86795939
87MP0004085_abnormal_heartbeat0.86169533
88MP0000678_abnormal_parathyroid_gland0.84675837
89MP0003137_abnormal_impulse_conducting0.84546697
90MP0004484_altered_response_of0.84507919
91MP0002090_abnormal_vision0.84190279
92MP0001485_abnormal_pinna_reflex0.83361344
93MP0000749_muscle_degeneration0.80725548
94MP0005503_abnormal_tendon_morphology0.80607982
95MP0000534_abnormal_ureter_morphology0.79334881
96MP0005551_abnormal_eye_electrophysiolog0.75086046
97MP0002877_abnormal_melanocyte_morpholog0.74752104
98MP0008874_decreased_physiological_sensi0.74381039
99MP0003172_abnormal_lysosome_physiology0.74063294
100MP0003045_fibrosis0.73908805
101MP0005187_abnormal_penis_morphology0.73677689
102MP0003861_abnormal_nervous_system0.72575145
103MP0002837_dystrophic_cardiac_calcinosis0.71415384
104MP0002896_abnormal_bone_mineralization0.71384895
105MP0004036_abnormal_muscle_relaxation0.70864276
106MP0004147_increased_porphyrin_level0.70624908
107MP0004043_abnormal_pH_regulation0.70548355
108MP0001963_abnormal_hearing_physiology0.69290751
109MP0000762_abnormal_tongue_morphology0.68801760
110MP0001984_abnormal_olfaction0.68648915
111MP0003787_abnormal_imprinting0.67842590
112MP0010030_abnormal_orbit_morphology0.67842177
113MP0000428_abnormal_craniofacial_morphol0.67226247
114MP0002108_abnormal_muscle_morphology0.66706323
115MP0003279_aneurysm0.65120397
116MP0009672_abnormal_birth_weight0.64403714
117MP0002752_abnormal_somatic_nervous0.64124923
118MP0002069_abnormal_eating/drinking_beha0.63428072
119MP0000467_abnormal_esophagus_morphology0.62740060
120MP0001943_abnormal_respiration0.62652150
121MP0010769_abnormal_survival0.61431447
122MP0004233_abnormal_muscle_weight0.61351683
123MP0001849_ear_inflammation0.61068909
124MP0000759_abnormal_skeletal_muscle0.59843213
125MP0003091_abnormal_cell_migration0.59708098
126MP0010678_abnormal_skin_adnexa0.59590923
127MP0005645_abnormal_hypothalamus_physiol0.58841512
128MP0004510_myositis0.58597316
129MP0006276_abnormal_autonomic_nervous0.58180249
130MP0005620_abnormal_muscle_contractility0.57943745
131MP0004134_abnormal_chest_morphology0.57815367
132MP0010768_mortality/aging0.57548943

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.60950806
2Focal motor seizures (HP:0011153)5.44178852
3Focal seizures (HP:0007359)4.46522268
4Action tremor (HP:0002345)4.43918307
5Supranuclear gaze palsy (HP:0000605)4.05571218
6Neurofibrillary tangles (HP:0002185)3.97114672
7Visual hallucinations (HP:0002367)3.93021701
8Progressive cerebellar ataxia (HP:0002073)3.58197704
9Ankle clonus (HP:0011448)3.56744112
10Cerebral inclusion bodies (HP:0100314)3.55621686
11Obstructive sleep apnea (HP:0002870)3.50124104
12Epileptic encephalopathy (HP:0200134)3.48971249
13Insidious onset (HP:0003587)3.35856902
14Termporal pattern (HP:0011008)3.35856902
15Dysmetria (HP:0001310)3.35802618
16Turricephaly (HP:0000262)3.34701707
17Atonic seizures (HP:0010819)3.23295640
18Protrusio acetabuli (HP:0003179)3.12607946
19Intention tremor (HP:0002080)3.12143780
20Dysdiadochokinesis (HP:0002075)3.07867299
21Scanning speech (HP:0002168)3.04471968
22Degeneration of the lateral corticospinal tracts (HP:0002314)2.94715799
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.94715799
24Arterial tortuosity (HP:0005116)2.86624837
25Gaze-evoked nystagmus (HP:0000640)2.82088500
26Generalized tonic-clonic seizures (HP:0002069)2.80738646
27Depression (HP:0000716)2.80188889
28Absence seizures (HP:0002121)2.79441725
29Abnormality of the corticospinal tract (HP:0002492)2.76655335
30Peripheral hypomyelination (HP:0007182)2.76279367
31Truncal ataxia (HP:0002078)2.74277928
32Poor eye contact (HP:0000817)2.70553804
33Megalencephaly (HP:0001355)2.69608138
34Dialeptic seizures (HP:0011146)2.69219664
35Broad-based gait (HP:0002136)2.66734774
36Onion bulb formation (HP:0003383)2.65666485
37Vascular tortuosity (HP:0004948)2.65238036
38Spastic gait (HP:0002064)2.64060764
39Febrile seizures (HP:0002373)2.63762516
40Postural instability (HP:0002172)2.61501693
41Urinary urgency (HP:0000012)2.56664771
42Impaired vibration sensation in the lower limbs (HP:0002166)2.54123950
43Abnormality of the left ventricular outflow tract (HP:0011103)2.50930082
44Subaortic stenosis (HP:0001682)2.50930082
45Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.49079070
46Aplasia involving bones of the extremities (HP:0009825)2.48546407
47Aplasia involving bones of the upper limbs (HP:0009823)2.48546407
48Aplasia of the phalanges of the hand (HP:0009802)2.48546407
49Anxiety (HP:0000739)2.47449190
50Exercise-induced myalgia (HP:0003738)2.47395691
51Diplopia (HP:0000651)2.46429839
52Abnormality of binocular vision (HP:0011514)2.46429839
53Hyperacusis (HP:0010780)2.45657266
54Abnormal social behavior (HP:0012433)2.45298964
55Impaired social interactions (HP:0000735)2.45298964
56Insomnia (HP:0100785)2.43657941
57Urinary bladder sphincter dysfunction (HP:0002839)2.43523833
58Hemiplegia (HP:0002301)2.35667373
59Hemiparesis (HP:0001269)2.33542077
60Ankyloglossia (HP:0010296)2.31439916
61Genetic anticipation (HP:0003743)2.30733446
62Alacrima (HP:0000522)2.30646725
63Broad metatarsal (HP:0001783)2.29097115
64Neuronal loss in central nervous system (HP:0002529)2.26734330
65Lower limb muscle weakness (HP:0007340)2.26609407
66Distal upper limb amyotrophy (HP:0007149)2.23806782
67Upper limb amyotrophy (HP:0009129)2.23806782
68Dysmetric saccades (HP:0000641)2.20197981
69Torticollis (HP:0000473)2.18702848
70Abnormal eating behavior (HP:0100738)2.16816341
71Shallow orbits (HP:0000586)2.14067990
72Increased variability in muscle fiber diameter (HP:0003557)2.13611612
73Cerebral hypomyelination (HP:0006808)2.13558187
74Postural tremor (HP:0002174)2.13312497
75Impaired smooth pursuit (HP:0007772)2.11850982
76Bowel incontinence (HP:0002607)2.11732043
77Achilles tendon contracture (HP:0001771)2.11197051
78Overriding aorta (HP:0002623)2.10051341
79Rapidly progressive (HP:0003678)2.08960551
80Papilledema (HP:0001085)2.08753183
81Pheochromocytoma (HP:0002666)2.08467881
82Flat cornea (HP:0007720)2.07516379
83Mutism (HP:0002300)2.07380688
84Premature rupture of membranes (HP:0001788)2.06814944
85Sudden death (HP:0001699)2.05440803
86Hammertoe (HP:0001765)2.04246835
87Tetraplegia (HP:0002445)2.03438902
88Abnormality of saccadic eye movements (HP:0000570)2.03344936
89Lower limb amyotrophy (HP:0007210)2.03018064
90Renal duplication (HP:0000075)1.99509854
91Bundle branch block (HP:0011710)1.98393359
92Akinesia (HP:0002304)1.98294702
93Ventricular fibrillation (HP:0001663)1.97857670
94Buphthalmos (HP:0000557)1.97182926
95Hand muscle atrophy (HP:0009130)1.95943640
96Gait ataxia (HP:0002066)1.94519706
97Focal dystonia (HP:0004373)1.94485742
98Distal sensory impairment (HP:0002936)1.92922165
99Slow progression (HP:0003677)1.91568019
100Amblyopia (HP:0000646)1.90252491
101Bladder diverticulum (HP:0000015)1.89630285
102Bronchomalacia (HP:0002780)1.89346024
103Abnormal large intestine physiology (HP:0012700)1.89247234
104Abnormality of the salivary glands (HP:0010286)1.88393660
105Drooling (HP:0002307)1.85812785
106Excessive salivation (HP:0003781)1.85812785
107Clumsiness (HP:0002312)1.85609007
108Exercise-induced muscle cramps (HP:0003710)1.85215062
109Abnormality of ocular smooth pursuit (HP:0000617)1.82425528
110Cerebral aneurysm (HP:0004944)1.82075867
111Rigidity (HP:0002063)1.81755635
112Decreased lacrimation (HP:0000633)1.80947251
113Decreased motor nerve conduction velocity (HP:0003431)1.80725386
114Clonus (HP:0002169)1.80604639
115Bradykinesia (HP:0002067)1.80359475
116Retinal dysplasia (HP:0007973)1.80095751
117Abnormality of the lower motor neuron (HP:0002366)1.79979076
118Absent speech (HP:0001344)1.79879471
119Ulnar bowing (HP:0003031)1.79659739
120Foot dorsiflexor weakness (HP:0009027)1.79441613
121Annular pancreas (HP:0001734)1.79275127
122Sleep apnea (HP:0010535)1.79265569
123Stereotypic behavior (HP:0000733)1.79064031
124Bowel diverticulosis (HP:0005222)1.78919637
125Pointed chin (HP:0000307)1.78895148
126Muscle stiffness (HP:0003552)1.77194252
127Abnormal auditory evoked potentials (HP:0006958)1.76884879
128Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.76257902
129Difficulty running (HP:0009046)1.75436187
130Truncus arteriosus (HP:0001660)1.75308503
131Abnormality of the periventricular white matter (HP:0002518)1.74590754
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73982766
133Hyporeflexia of lower limbs (HP:0002600)1.72896620
134Abnormality of the Achilles tendon (HP:0005109)1.72663856
135Craniofacial dystonia (HP:0012179)1.72487945
136Mitral regurgitation (HP:0001653)1.72096540
137Apathy (HP:0000741)1.69269960
138Elfin facies (HP:0004428)1.68334632
139Abnormality of the foot musculature (HP:0001436)1.67940767
140Sensory axonal neuropathy (HP:0003390)1.67196123
141Progressive inability to walk (HP:0002505)1.66948012
142Hypoventilation (HP:0002791)1.66287747
143Abnormality of cochlea (HP:0000375)1.65552360
144Morphological abnormality of the inner ear (HP:0011390)1.63678133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.56836488
2EPHA43.44104696
3MAP3K93.03733633
4PAK62.53675677
5DAPK22.33689463
6NTRK12.30692965
7MAP3K42.28083805
8PRKD32.25438555
9KSR22.22281724
10STK392.13932210
11MINK12.09344899
12CDK191.95905655
13OXSR11.87214911
14CAMKK11.85970937
15EEF2K1.75149752
16TYRO31.61683341
17WNK11.58885936
18CDK51.54675693
19UHMK11.53501804
20RIPK41.53444475
21MAP2K71.52478576
22NTRK21.51587001
23ICK1.49768643
24PNCK1.44342071
25MARK11.43929571
26CAMKK21.43076337
27MAP2K41.42846619
28PLK21.30710552
29SGK2231.30246421
30SGK4941.30246421
31DDR21.29357534
32STK381.28704177
33MAP3K21.26728203
34RIPK11.19324704
35PTK21.19260772
36CAMK2B1.18188146
37FGFR21.13239669
38DMPK1.12635609
39PTK2B1.12164817
40GRK51.11469190
41PAK31.11466325
42EPHB11.11333078
43ROCK21.11149439
44CDK151.10102631
45BRSK11.09170217
46CDK141.08818475
47RET1.07732447
48SMG11.06518003
49CDK181.05869198
50PRKCH1.04804669
51CDK121.03747062
52NEK11.03491167
53ARAF1.02672990
54CAMK2A1.02278188
55PRPF4B1.02079542
56KSR11.00206518
57CAMK1G0.98515281
58MAP3K130.97949585
59CCNB10.97806214
60CASK0.97261397
61CDK11A0.96067330
62CAMK2D0.95264068
63LMTK20.94881967
64CAMK10.93982076
65PRKCG0.93415704
66PKN10.92503048
67PHKG20.90534309
68PHKG10.90534309
69PINK10.89447431
70DAPK30.89099982
71STK110.86285641
72PDPK10.86119029
73FES0.86063520
74PDGFRA0.85864781
75MARK20.84679875
76LATS20.83072269
77PAK20.82431489
78CAMK2G0.82034295
79WNK40.81959700
80CDK80.81532743
81BMX0.80856978
82ALK0.80536983
83PKN20.78664449
84TRIB30.77006244
85TNIK0.76075831
86MAP3K120.76074279
87DAPK10.75517509
88FER0.75375716
89PRKD10.73960553
90FGR0.73282736
91PDK10.72474964
92LIMK10.70828279
93TAOK10.68414487
94SGK30.67819418
95FGFR40.67522198
96SGK10.66782587
97MAPK130.65878935
98MAPK120.65320027
99SIK20.64350683
100PRKCE0.63293099
101NEK60.63242361
102MAP3K10.62949547
103MTOR0.62182105
104SIK10.62034194
105CDC42BPA0.61618349
106BRAF0.60662794
107CSNK1G20.59677211
108FYN0.59046263
109BCR0.58308064
110MET0.58189639
111TESK10.57743467
112SCYL20.55737348
113MAPK100.52681970
114SGK20.50903099
115RAF10.50618290
116RPS6KA30.50562716
117MAP2K10.47649587
118PDGFRB0.47613933
119ROCK10.46167061
120PRKG20.45761620
121MOS0.45262412
122MAP3K70.44237303
123DYRK1A0.42900122
124FGFR10.40033031
125CAMK40.34572614
126CSNK1E0.34043604
127BMPR20.33736103
128TTK0.32350027

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.76463821
2Synaptic vesicle cycle_Homo sapiens_hsa047212.70868573
3Glutamatergic synapse_Homo sapiens_hsa047242.41950595
4Circadian entrainment_Homo sapiens_hsa047132.40352771
5GABAergic synapse_Homo sapiens_hsa047272.37266640
6Long-term potentiation_Homo sapiens_hsa047202.33467356
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30229988
8Olfactory transduction_Homo sapiens_hsa047402.17132175
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15960432
10Morphine addiction_Homo sapiens_hsa050322.12968553
11Salivary secretion_Homo sapiens_hsa049702.12192207
12Nitrogen metabolism_Homo sapiens_hsa009102.00982311
13Gastric acid secretion_Homo sapiens_hsa049711.99893979
14Amphetamine addiction_Homo sapiens_hsa050311.99709289
15Long-term depression_Homo sapiens_hsa047301.83468856
16Dopaminergic synapse_Homo sapiens_hsa047281.82577274
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69290486
18Insulin secretion_Homo sapiens_hsa049111.67389873
19Cholinergic synapse_Homo sapiens_hsa047251.67370159
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62907605
21Renin secretion_Homo sapiens_hsa049241.57974709
22Oxytocin signaling pathway_Homo sapiens_hsa049211.55161417
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49981814
24Vitamin B6 metabolism_Homo sapiens_hsa007501.47612084
25Taste transduction_Homo sapiens_hsa047421.44264769
26Serotonergic synapse_Homo sapiens_hsa047261.44125307
27Gap junction_Homo sapiens_hsa045401.44108666
28GnRH signaling pathway_Homo sapiens_hsa049121.43581064
29Cocaine addiction_Homo sapiens_hsa050301.41727732
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40511901
31Calcium signaling pathway_Homo sapiens_hsa040201.35872579
32Glioma_Homo sapiens_hsa052141.23917277
33cAMP signaling pathway_Homo sapiens_hsa040241.22414797
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19480596
35Axon guidance_Homo sapiens_hsa043601.18275106
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17373055
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16357446
38Estrogen signaling pathway_Homo sapiens_hsa049151.16153804
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16144263
40Collecting duct acid secretion_Homo sapiens_hsa049661.15766623
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15064169
42Dilated cardiomyopathy_Homo sapiens_hsa054141.14358639
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.12042081
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.09590989
45Melanogenesis_Homo sapiens_hsa049161.08101751
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07823951
47Dorso-ventral axis formation_Homo sapiens_hsa043201.07631102
48ErbB signaling pathway_Homo sapiens_hsa040121.01978468
49Pancreatic secretion_Homo sapiens_hsa049721.01583876
50Cardiac muscle contraction_Homo sapiens_hsa042601.01544412
51Type II diabetes mellitus_Homo sapiens_hsa049300.99561501
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92979881
53Histidine metabolism_Homo sapiens_hsa003400.92032267
54Arginine and proline metabolism_Homo sapiens_hsa003300.91110990
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.88139913
56Adherens junction_Homo sapiens_hsa045200.87492580
57Renal cell carcinoma_Homo sapiens_hsa052110.86478803
58Endocytosis_Homo sapiens_hsa041440.84306041
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.84160466
60Vibrio cholerae infection_Homo sapiens_hsa051100.82145266
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82123756
62Chronic myeloid leukemia_Homo sapiens_hsa052200.82078949
63Thyroid hormone synthesis_Homo sapiens_hsa049180.80668850
64Hippo signaling pathway_Homo sapiens_hsa043900.79180684
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78650314
66Choline metabolism in cancer_Homo sapiens_hsa052310.77879939
67Endometrial cancer_Homo sapiens_hsa052130.76011626
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75457357
69VEGF signaling pathway_Homo sapiens_hsa043700.74994131
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74459331
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74375759
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73839346
73Arginine biosynthesis_Homo sapiens_hsa002200.73484692
74MAPK signaling pathway_Homo sapiens_hsa040100.72984155
75Ras signaling pathway_Homo sapiens_hsa040140.71789152
76Rap1 signaling pathway_Homo sapiens_hsa040150.71431386
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71186793
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70069198
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69520858
80Oocyte meiosis_Homo sapiens_hsa041140.68694144
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66500752
82Glucagon signaling pathway_Homo sapiens_hsa049220.66071464
83Inositol phosphate metabolism_Homo sapiens_hsa005620.64803879
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.63440057
85AMPK signaling pathway_Homo sapiens_hsa041520.63134474
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62807179
87Tight junction_Homo sapiens_hsa045300.62205033
88Insulin signaling pathway_Homo sapiens_hsa049100.61894307
89Ether lipid metabolism_Homo sapiens_hsa005650.61181846
90Protein digestion and absorption_Homo sapiens_hsa049740.60876234
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60049346
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59829233
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57591658
94Focal adhesion_Homo sapiens_hsa045100.54513518
95Biosynthesis of amino acids_Homo sapiens_hsa012300.54298073
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54158240
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52910662
98MicroRNAs in cancer_Homo sapiens_hsa052060.52359002
99Pancreatic cancer_Homo sapiens_hsa052120.51687246
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51361540
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50710641
102Colorectal cancer_Homo sapiens_hsa052100.50554894
103ECM-receptor interaction_Homo sapiens_hsa045120.50551294
104Ovarian steroidogenesis_Homo sapiens_hsa049130.50330812
105beta-Alanine metabolism_Homo sapiens_hsa004100.50299527
106Platelet activation_Homo sapiens_hsa046110.50190360
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49871618
108Phototransduction_Homo sapiens_hsa047440.48264172
109Wnt signaling pathway_Homo sapiens_hsa043100.48051868
110Proteoglycans in cancer_Homo sapiens_hsa052050.47508791
111Amoebiasis_Homo sapiens_hsa051460.46650895
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46487549
113Prion diseases_Homo sapiens_hsa050200.46100408
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45763781
115Non-small cell lung cancer_Homo sapiens_hsa052230.45717942
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43348027
117Bile secretion_Homo sapiens_hsa049760.42937561
118mTOR signaling pathway_Homo sapiens_hsa041500.42379646
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39961914
120Mineral absorption_Homo sapiens_hsa049780.39799875
121Hedgehog signaling pathway_Homo sapiens_hsa043400.39574343
122Alcoholism_Homo sapiens_hsa050340.39492707
123Chemokine signaling pathway_Homo sapiens_hsa040620.37892954
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37235280
125* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36413038

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