SEPT9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19025928
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.19025928
3regulation of extracellular matrix disassembly (GO:0010715)3.59457770
4antigen processing and presentation of endogenous antigen (GO:0019883)3.59141579
5protein localization to endosome (GO:0036010)3.46095787
6positive regulation of gamma-delta T cell activation (GO:0046645)3.39593961
7positive regulation of histone deacetylation (GO:0031065)3.35298322
8negative T cell selection (GO:0043383)3.35006876
9positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.33238503
10negative thymic T cell selection (GO:0045060)3.33009354
11DNA unwinding involved in DNA replication (GO:0006268)3.25682060
12positive thymic T cell selection (GO:0045059)3.25221944
13mannose metabolic process (GO:0006013)3.25007619
14regulation of protein heterodimerization activity (GO:0043497)3.17479863
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17106793
16regulation of gamma-delta T cell differentiation (GO:0045586)3.15225336
17pinocytosis (GO:0006907)3.13519681
18thymic T cell selection (GO:0045061)3.06180567
19NIK/NF-kappaB signaling (GO:0038061)3.06095197
20modulation by symbiont of host cellular process (GO:0044068)3.02426114
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01873659
22response to muramyl dipeptide (GO:0032495)3.01343967
23T cell apoptotic process (GO:0070231)3.00587316
24positive regulation by symbiont of host defense response (GO:0052509)3.00505068
25modulation by symbiont of host defense response (GO:0052031)3.00505068
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00505068
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00505068
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.00505068
29modulation by symbiont of host immune response (GO:0052553)3.00505068
30positive regulation of Cdc42 GTPase activity (GO:0043089)2.96137920
31Arp2/3 complex-mediated actin nucleation (GO:0034314)2.88962485
32embryonic process involved in female pregnancy (GO:0060136)2.88822134
33cell-substrate adherens junction assembly (GO:0007045)2.88248973
34focal adhesion assembly (GO:0048041)2.88248973
35leukocyte aggregation (GO:0070486)2.87786893
36endothelial tube morphogenesis (GO:0061154)2.84143587
37morphogenesis of an endothelium (GO:0003159)2.84143587
38barbed-end actin filament capping (GO:0051016)2.84067166
39regulation of early endosome to late endosome transport (GO:2000641)2.83787990
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81337919
41negative regulation of cell killing (GO:0031342)2.81337919
42stress fiber assembly (GO:0043149)2.78482337
43signal complex assembly (GO:0007172)2.78286911
44negative regulation of fatty acid transport (GO:2000192)2.74519986
45modulation by virus of host process (GO:0019054)2.74510629
46regulation of extracellular matrix organization (GO:1903053)2.74505953
47regulation of gamma-delta T cell activation (GO:0046643)2.74071559
48response to laminar fluid shear stress (GO:0034616)2.73117512
49regulation of histone H3-K27 methylation (GO:0061085)2.71704655
50COPI coating of Golgi vesicle (GO:0048205)2.69805003
51Golgi transport vesicle coating (GO:0048200)2.69805003
52heterochromatin organization (GO:0070828)2.69342680
53positive regulation of protein deacetylation (GO:0090312)2.68918507
54B cell receptor signaling pathway (GO:0050853)2.68735862
55regulation of glucose import in response to insulin stimulus (GO:2001273)2.68299985
56activation of Rac GTPase activity (GO:0032863)2.68281694
57positive regulation of extracellular matrix organization (GO:1903055)2.67072245
58regulation of NFAT protein import into nucleus (GO:0051532)2.66315892
59tolerance induction (GO:0002507)2.66313050
60regulation of translational fidelity (GO:0006450)2.64908677
61maternal placenta development (GO:0001893)2.64308677
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.63834550
63cell-substrate junction assembly (GO:0007044)2.63118219
64regulation of defense response to virus by virus (GO:0050690)2.62423200
65dosage compensation (GO:0007549)2.62269975
66endodermal cell differentiation (GO:0035987)2.61414509
67regulation of T cell tolerance induction (GO:0002664)2.60378686
68negative regulation of phagocytosis (GO:0050765)2.60209414
69lymphocyte apoptotic process (GO:0070227)2.59950748
70regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.59415154
71glucocorticoid receptor signaling pathway (GO:0042921)2.59021131
72folic acid-containing compound biosynthetic process (GO:0009396)2.58547632
73histone H3-K36 demethylation (GO:0070544)2.57604355
74germinal center formation (GO:0002467)2.57138195
75nuclear pore complex assembly (GO:0051292)2.57102214
76detection of bacterium (GO:0016045)2.56864907
77positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.56249613
78T cell selection (GO:0045058)2.55689869
79RNA stabilization (GO:0043489)2.54699478
80mRNA stabilization (GO:0048255)2.54699478
81positive regulation of lamellipodium assembly (GO:0010592)2.53768179
82detection of other organism (GO:0098543)2.50321104
83natural killer cell differentiation (GO:0001779)2.50097168
84activation of MAPKKK activity (GO:0000185)2.49743610
85negative regulation of erythrocyte differentiation (GO:0045647)2.49476836
86positive T cell selection (GO:0043368)2.48917629
87protein localization to kinetochore (GO:0034501)2.47688912
88antigen processing and presentation via MHC class Ib (GO:0002475)2.47389662
89negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.46359359
90positive regulation of tolerance induction (GO:0002645)2.45434524
91regulation of cholesterol homeostasis (GO:2000188)2.42537661
92regulation of type I interferon-mediated signaling pathway (GO:0060338)2.42323513
93macrophage activation involved in immune response (GO:0002281)2.42101770
94myeloid dendritic cell differentiation (GO:0043011)2.41575115
95cellular response to virus (GO:0098586)2.40858110
96nuclear pore organization (GO:0006999)2.40542453
97apoptotic cell clearance (GO:0043277)2.39854716
98mitotic nuclear envelope disassembly (GO:0007077)2.39123857
993-UTR-mediated mRNA stabilization (GO:0070935)2.37914269
100regulation of interleukin-12 biosynthetic process (GO:0045075)2.37849311
101JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.37265968
102response to peptidoglycan (GO:0032494)2.37095984
103basement membrane organization (GO:0071711)2.36859120
104response to interleukin-15 (GO:0070672)2.36562523
105regulation of T-helper 2 cell differentiation (GO:0045628)2.35438835
106regulation of mammary gland epithelial cell proliferation (GO:0033599)2.33758175
107negative regulation of viral release from host cell (GO:1902187)2.33473100
108activation of JUN kinase activity (GO:0007257)2.33172939
109negative regulation of RNA splicing (GO:0033119)2.32623026
110NLS-bearing protein import into nucleus (GO:0006607)2.32380916
111semaphorin-plexin signaling pathway (GO:0071526)2.30937622
112positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.30018222
113planar cell polarity pathway involved in neural tube closure (GO:0090179)2.29536685
114hypotonic response (GO:0006971)2.29192506
115hippo signaling (GO:0035329)2.29043735
116mitotic G1 DNA damage checkpoint (GO:0031571)2.28499101
117regulation of necroptotic process (GO:0060544)2.27765879
118T cell costimulation (GO:0031295)2.26919005
119positive regulation of lamellipodium organization (GO:1902745)2.26754985
120corticosteroid receptor signaling pathway (GO:0031958)2.26455768
121hepatocyte apoptotic process (GO:0097284)2.26232801
122apoptotic process involved in morphogenesis (GO:0060561)2.24673339
123regulation of lipid kinase activity (GO:0043550)2.24205203
124positive regulation of epithelial to mesenchymal transition (GO:0010718)2.24113939
125negative regulation of toll-like receptor signaling pathway (GO:0034122)2.23579986
126germ cell migration (GO:0008354)2.23419074
127nuclear envelope disassembly (GO:0051081)2.23382097
128membrane disassembly (GO:0030397)2.23382097
129positive regulation of blood vessel endothelial cell migration (GO:0043536)2.23196496
130negative regulation of cell size (GO:0045792)2.22264747
131lymphocyte costimulation (GO:0031294)2.22187765
132regulation of B cell receptor signaling pathway (GO:0050855)2.21933479
133T cell migration (GO:0072678)2.21903329
134retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.21500341
135tyrosine phosphorylation of STAT protein (GO:0007260)2.21079357
136pentose-phosphate shunt (GO:0006098)2.21007085
137positive regulation of protein import into nucleus, translocation (GO:0033160)2.19991142
138lipopolysaccharide-mediated signaling pathway (GO:0031663)2.19913287
139CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.19116351
140regulation of leukocyte degranulation (GO:0043300)2.18700847
141cellular response to interleukin-4 (GO:0071353)2.18684132
142ribosomal small subunit assembly (GO:0000028)2.17873274
143heterotypic cell-cell adhesion (GO:0034113)2.17255965
144epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14261524
145positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.12872354
146regulation of fatty acid beta-oxidation (GO:0031998)2.12518877
147organ regeneration (GO:0031100)2.12232612
148mitotic G1/S transition checkpoint (GO:0044819)2.12111712
149growth hormone receptor signaling pathway (GO:0060396)2.11799459
150leukocyte cell-cell adhesion (GO:0007159)2.11629417
151adherens junction assembly (GO:0034333)2.11381323
152DNA duplex unwinding (GO:0032508)2.11051888
153regulation of response to interferon-gamma (GO:0060330)2.10939208
154platelet aggregation (GO:0070527)2.10687436
155interferon-gamma production (GO:0032609)2.10024185
156skin morphogenesis (GO:0043589)2.09708292
157regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.08483695
158positive regulation of endothelial cell apoptotic process (GO:2000353)2.08092166
159DNA geometric change (GO:0032392)2.07293981
160cellular response to epidermal growth factor stimulus (GO:0071364)2.06759324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.20445348
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.31582203
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.63983484
4MYC_22102868_ChIP-Seq_BL_Human3.44071427
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.34168407
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98408205
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.92950150
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.85841899
9VDR_21846776_ChIP-Seq_THP-1_Human2.57332407
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41721410
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40865410
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.26929081
13TCF7_22412390_ChIP-Seq_EML_Mouse2.15951667
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.10962583
15MAF_26560356_Chip-Seq_TH1_Human2.09180647
16CLOCK_20551151_ChIP-Seq_293T_Human1.98810222
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94854577
18UTX_26944678_Chip-Seq_JUKART_Human1.92044432
19KDM2B_26808549_Chip-Seq_DND41_Human1.91058405
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89742219
21KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83621839
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77732099
23MYB_26560356_Chip-Seq_TH2_Human1.74294635
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72426173
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72205757
26BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71067769
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70563408
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69376382
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67683243
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66658754
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66423029
32VDR_24763502_ChIP-Seq_THP-1_Human1.61954867
33KDM2B_26808549_Chip-Seq_K562_Human1.61754009
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61565303
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59515368
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.55835665
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55640036
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55531837
39SCL_19346495_ChIP-Seq_HPC-7_Human1.53026035
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52504616
41MYB_26560356_Chip-Seq_TH1_Human1.52239729
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50584302
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49449660
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48220641
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47130694
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.46268179
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.45333232
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44919747
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42401301
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.41222442
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39861649
52RUNX_20019798_ChIP-Seq_JUKART_Human1.39146812
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38473940
54LXR_22292898_ChIP-Seq_THP-1_Human1.35139459
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34451299
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32856297
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32288002
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31799097
59MAF_26560356_Chip-Seq_TH2_Human1.31058770
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30745940
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29409999
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28546442
63ZNF263_19887448_ChIP-Seq_K562_Human1.27957340
64RACK7_27058665_Chip-Seq_MCF-7_Human1.27710597
65EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27405098
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26998644
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25305794
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.24978003
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.23103569
70SPI1_23547873_ChIP-Seq_NB4_Human1.23099417
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23004087
72NCOR1_26117541_ChIP-Seq_K562_Human1.22614179
73ATF3_27146783_Chip-Seq_COLON_Human1.22389022
74BP1_19119308_ChIP-ChIP_Hs578T_Human1.21998734
75CIITA_25753668_ChIP-Seq_RAJI_Human1.19274734
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.18503436
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18365003
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18246829
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.17538304
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16532969
81P68_20966046_ChIP-Seq_HELA_Human1.16311938
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15789575
83SPI1_23127762_ChIP-Seq_K562_Human1.15094653
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14755322
85SMC4_20622854_ChIP-Seq_HELA_Human1.14112498
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13153258
87AR_21909140_ChIP-Seq_LNCAP_Human1.13054033
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.13008461
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12404749
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.12340282
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.11351939
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11252221
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11221093
94XRN2_22483619_ChIP-Seq_HELA_Human1.09916243
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07399829
96RUNX1_27514584_Chip-Seq_MCF-7_Human1.07360462
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05979562
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.05833843
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05103058
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04441481
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03270297
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02818760
103CREB1_26743006_Chip-Seq_LNCaP_Human1.02245142
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01995102
105ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01787261
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01752632
107GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01399222
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01280864
109DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01006167
110ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00279612
111TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99928068
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99758524
113TFEB_21752829_ChIP-Seq_HELA_Human0.99732629
114PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99658817
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99525507
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99511973
117ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99144141
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99084200
119NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97081325
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97050950
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96750261
122PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96527165
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.95242091
124TRIM28_21343339_ChIP-Seq_HEK293_Human0.95045660
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94979658
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94177505
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94142837
128TP53_22127205_ChIP-Seq_IMR90_Human0.92692572
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92255397
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91068392
131UBF1/2_26484160_Chip-Seq_HMECs_Human0.90844695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.61424103
2MP0010352_gastrointestinal_tract_polyps2.74350108
3MP0005451_abnormal_body_composition2.55122213
4MP0003300_gastrointestinal_ulcer2.51620756
5MP0005076_abnormal_cell_differentiation2.51364621
6MP0008438_abnormal_cutaneous_collagen2.50844122
7MP0005058_abnormal_lysosome_morphology2.42619228
8MP0009278_abnormal_bone_marrow2.32254026
9MP0003566_abnormal_cell_adhesion2.15594849
10MP0003172_abnormal_lysosome_physiology2.00585053
11MP0006054_spinal_hemorrhage1.95009409
12MP0004808_abnormal_hematopoietic_stem1.94148486
13MP0002396_abnormal_hematopoietic_system1.93037044
14MP0003763_abnormal_thymus_physiology1.91886439
15MP0008260_abnormal_autophagy1.91662614
16MP0000685_abnormal_immune_system1.87254844
17MP0003279_aneurysm1.85810952
18MP0005023_abnormal_wound_healing1.83577307
19MP0003303_peritoneal_inflammation1.83410862
20MP0003436_decreased_susceptibility_to1.80688765
21MP0003191_abnormal_cellular_cholesterol1.78034959
22MP0005257_abnormal_intraocular_pressure1.70971877
23MP0004858_abnormal_nervous_system1.64472070
24MP0000733_abnormal_muscle_development1.63340374
25MP0002877_abnormal_melanocyte_morpholog1.60362515
26MP0009333_abnormal_splenocyte_physiolog1.57591517
27MP0004381_abnormal_hair_follicle1.51193182
28MP0000858_altered_metastatic_potential1.51110889
29MP0003091_abnormal_cell_migration1.44853450
30MP0009053_abnormal_anal_canal1.43525592
31MP0005409_darkened_coat_color1.43495956
32MP0010307_abnormal_tumor_latency1.40628477
33MP0005623_abnormal_meninges_morphology1.39368164
34MP0002998_abnormal_bone_remodeling1.39119508
35MP0004947_skin_inflammation1.38985987
36MP0005397_hematopoietic_system_phenotyp1.38709098
37MP0001545_abnormal_hematopoietic_system1.38709098
38MP0001348_abnormal_lacrimal_gland1.38296713
39MP0002398_abnormal_bone_marrow1.37844348
40MP0000703_abnormal_thymus_morphology1.36079281
41MP0003448_altered_tumor_morphology1.34975832
42MP0001835_abnormal_antigen_presentation1.34971736
43MP0004272_abnormal_basement_membrane1.31192048
44MP0002405_respiratory_system_inflammati1.30515388
45MP0001800_abnormal_humoral_immune1.28781457
46MP0001849_ear_inflammation1.24755168
47MP0002166_altered_tumor_susceptibility1.24317878
48MP0002452_abnormal_antigen_presenting1.23828913
49MP0004197_abnormal_fetal_growth/weight/1.23546467
50MP0005464_abnormal_platelet_physiology1.23430220
51MP0002420_abnormal_adaptive_immunity1.23322438
52MP0001819_abnormal_immune_cell1.22634393
53MP0001915_intracranial_hemorrhage1.22320577
54MP0005671_abnormal_response_to1.21275973
55MP0002722_abnormal_immune_system1.21008923
56MP0004264_abnormal_extraembryonic_tissu1.19851820
57MP0008007_abnormal_cellular_replicative1.19529668
58MP0002933_joint_inflammation1.16528972
59MP0010155_abnormal_intestine_physiology1.16489699
60MP0000490_abnormal_crypts_of1.14983908
61MP0000465_gastrointestinal_hemorrhage1.14575378
62MP0002086_abnormal_extraembryonic_tissu1.14347611
63MP0001790_abnormal_immune_system1.13465507
64MP0005387_immune_system_phenotype1.13465507
65MP0005000_abnormal_immune_tolerance1.13206778
66MP0002254_reproductive_system_inflammat1.11532212
67MP0005275_abnormal_skin_tensile1.11056421
68MP0003077_abnormal_cell_cycle1.11053978
69MP0000716_abnormal_immune_system1.10497948
70MP0002723_abnormal_immune_serum1.08848683
71MP0003453_abnormal_keratinocyte_physiol1.08705325
72MP0000689_abnormal_spleen_morphology1.08645265
73MP0004510_myositis1.05210368
74MP0003724_increased_susceptibility_to1.05164800
75MP0001730_embryonic_growth_arrest1.04865743
76MP0002419_abnormal_innate_immunity1.03070036
77MP0002429_abnormal_blood_cell1.02912310
78MP0005025_abnormal_response_to1.02663827
79MP0010234_abnormal_vibrissa_follicle1.02539225
80MP0006082_CNS_inflammation1.02327603
81MP0000350_abnormal_cell_proliferation1.01361644
82MP0003866_abnormal_defecation1.01153757
83MP0001958_emphysema1.00480280
84MP0002006_tumorigenesis0.99185393
85MP0004957_abnormal_blastocyst_morpholog0.97377269
86MP0003111_abnormal_nucleus_morphology0.97103333
87MP0001533_abnormal_skeleton_physiology0.96275177
88MP0005621_abnormal_cell_physiology0.96153593
89MP0001851_eye_inflammation0.96005026
90MP0002796_impaired_skin_barrier0.95896554
91MP0003123_paternal_imprinting0.95656614
92MP0003984_embryonic_growth_retardation0.95259646
93MP0002088_abnormal_embryonic_growth/wei0.95221195
94MP0002148_abnormal_hypersensitivity_rea0.95051586
95MP0009840_abnormal_foam_cell0.94810977
96MP0002060_abnormal_skin_morphology0.94547261
97MP0000767_abnormal_smooth_muscle0.94259937
98MP0005666_abnormal_adipose_tissue0.93734638
99MP0002019_abnormal_tumor_incidence0.92594506
100MP0001243_abnormal_dermal_layer0.92262961
101MP0009785_altered_susceptibility_to0.91925432
102MP0001873_stomach_inflammation0.91649641
103MP0010030_abnormal_orbit_morphology0.91175526
104MP0003183_abnormal_peptide_metabolism0.91063410
105MP0005310_abnormal_salivary_gland0.91043629
106MP0003567_abnormal_fetal_cardiomyocyte0.90584703
107MP0001697_abnormal_embryo_size0.89730264
108MP0001672_abnormal_embryogenesis/_devel0.88816382
109MP0005380_embryogenesis_phenotype0.88816382
110MP0002925_abnormal_cardiovascular_devel0.88228824
111MP0000428_abnormal_craniofacial_morphol0.87408262
112MP0000537_abnormal_urethra_morphology0.86159162
113MP0001853_heart_inflammation0.84506714
114MP0004185_abnormal_adipocyte_glucose0.83519845
115MP0000569_abnormal_digit_pigmentation0.83445746
116MP0005390_skeleton_phenotype0.82926256
117MP0010368_abnormal_lymphatic_system0.82409210
118MP0010094_abnormal_chromosome_stability0.82270762
119MP0002080_prenatal_lethality0.81709028
120MP0003115_abnormal_respiratory_system0.81308099
121MP0002084_abnormal_developmental_patter0.81083165
122MP0001845_abnormal_inflammatory_respons0.80429520
123MP0003828_pulmonary_edema0.80148448
124MP0002089_abnormal_postnatal_growth/wei0.79854708
125MP0005375_adipose_tissue_phenotype0.79786362
126MP0000604_amyloidosis0.79429512
127MP0000678_abnormal_parathyroid_gland0.79384815
128MP0004233_abnormal_muscle_weight0.79174722
129MP0003329_amyloid_beta_deposits0.77411841
130MP0002009_preneoplasia0.75885896
131MP0005501_abnormal_skin_physiology0.75343766
132MP0001216_abnormal_epidermal_layer0.73717309
133MP0003795_abnormal_bone_structure0.72288941
134MP0003075_altered_response_to0.71257786
135MP0008469_abnormal_protein_level0.69756205

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.09925382
2Cerebral aneurysm (HP:0004944)3.37942427
3Increased density of long bones (HP:0006392)3.10871180
4Shallow orbits (HP:0000586)3.10626595
5Short 4th metacarpal (HP:0010044)2.99931390
6Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.99931390
7Premature rupture of membranes (HP:0001788)2.91359079
8Ankle contracture (HP:0006466)2.88858932
9Broad face (HP:0000283)2.82709818
10Hyperacusis (HP:0010780)2.79536944
11Peritonitis (HP:0002586)2.61025877
12Dilatation of the ascending aorta (HP:0005111)2.60417104
13Aortic aneurysm (HP:0004942)2.58992868
14Cervical subluxation (HP:0003308)2.58056509
15Mitral valve prolapse (HP:0001634)2.50312256
16Abnormality of the 4th metacarpal (HP:0010012)2.49384957
17Selective tooth agenesis (HP:0001592)2.44895930
18Subacute progressive viral hepatitis (HP:0006572)2.42467481
19Aortic dissection (HP:0002647)2.41572623
20Abnormal platelet volume (HP:0011876)2.38720421
21Distal lower limb amyotrophy (HP:0008944)2.37829708
22Flat acetabular roof (HP:0003180)2.35658942
23Abnormality of macrophages (HP:0004311)2.33250558
24Elevated erythrocyte sedimentation rate (HP:0003565)2.32158826
25Eczematoid dermatitis (HP:0000976)2.31183614
26Obstructive sleep apnea (HP:0002870)2.30447093
27Increased mean platelet volume (HP:0011877)2.29677042
28Bladder diverticulum (HP:0000015)2.28037138
29Spinal cord lesions (HP:0100561)2.26989631
30Syringomyelia (HP:0003396)2.26989631
31Colitis (HP:0002583)2.23780214
32Thrombocytosis (HP:0001894)2.19558971
33Deep venous thrombosis (HP:0002625)2.19380247
34Increased IgE level (HP:0003212)2.18553324
35T lymphocytopenia (HP:0005403)2.18499294
36Genu recurvatum (HP:0002816)2.15198316
37Persistence of primary teeth (HP:0006335)2.14552175
38Hemorrhage of the eye (HP:0011885)2.14450165
39Abnormality of the peritoneum (HP:0002585)2.14306453
40Myositis (HP:0100614)2.14012380
41Gastrointestinal stroma tumor (HP:0100723)2.11145126
42Achilles tendon contracture (HP:0001771)2.08840192
43Renal duplication (HP:0000075)2.08290499
44Abnormality of T cell number (HP:0011839)2.07743582
45Thin bony cortex (HP:0002753)2.07067216
46Emphysema (HP:0002097)2.06192936
47Nasal polyposis (HP:0100582)2.05382849
48Osteolytic defects of the hand bones (HP:0009699)2.04992334
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.04992334
50Aneurysm (HP:0002617)2.04871011
51Gastrointestinal inflammation (HP:0004386)2.02545367
52Bowel diverticulosis (HP:0005222)2.02397624
53Deviation of the hallux (HP:0010051)2.01950121
54Bicuspid aortic valve (HP:0001647)1.99627182
55Ulnar bowing (HP:0003031)1.99261540
56Recurrent fungal infections (HP:0002841)1.99152178
57Long palpebral fissure (HP:0000637)1.98597518
58Spontaneous hematomas (HP:0007420)1.97905573
59Increased variability in muscle fiber diameter (HP:0003557)1.97812162
60Hallux valgus (HP:0001822)1.97071985
61Abnormality of the nasal mucosa (HP:0000433)1.94827271
62Dysostosis multiplex (HP:0000943)1.94552174
63Recurrent abscess formation (HP:0002722)1.94226167
64Radial bowing (HP:0002986)1.93575243
65Abnormality of the thoracic spine (HP:0100711)1.92801132
66Recurrent bacterial skin infections (HP:0005406)1.91916704
67Abnormality of the calcaneus (HP:0008364)1.91568649
68Arterial tortuosity (HP:0005116)1.91238776
69Broad metatarsal (HP:0001783)1.90993448
70Blue sclerae (HP:0000592)1.90446563
71Abnormality of the Achilles tendon (HP:0005109)1.90302174
72Polygenic inheritance (HP:0010982)1.90060278
73Recurrent viral infections (HP:0004429)1.89546410
74Fragile skin (HP:0001030)1.88492162
75Centrally nucleated skeletal muscle fibers (HP:0003687)1.87209569
76Asymmetry of the thorax (HP:0001555)1.85439572
77Deviation of the thumb (HP:0009603)1.85425938
78Increased connective tissue (HP:0009025)1.85020217
79Striae distensae (HP:0001065)1.84461403
80Renovascular hypertension (HP:0100817)1.83948713
81Vertebral compression fractures (HP:0002953)1.83895089
82Segmental peripheral demyelination/remyelination (HP:0003481)1.81879873
83Vascular tortuosity (HP:0004948)1.81758748
84Meningitis (HP:0001287)1.81069334
85Enlarged penis (HP:0000040)1.81060465
86Distal lower limb muscle weakness (HP:0009053)1.79525283
87Abnormality of skeletal muscle fiber size (HP:0012084)1.79415675
88Inflammation of the large intestine (HP:0002037)1.78855091
89Increased nuchal translucency (HP:0010880)1.77561622
90Disproportionate tall stature (HP:0001519)1.77060768
91Gingivitis (HP:0000230)1.76810833
92Hematochezia (HP:0002573)1.76720610
93Abnormality of T cells (HP:0002843)1.75807129
94High pitched voice (HP:0001620)1.73467260
95Atrophic scars (HP:0001075)1.73430039
96Biconcave vertebral bodies (HP:0004586)1.73353600
97Rectal prolapse (HP:0002035)1.72945861
98Mediastinal lymphadenopathy (HP:0100721)1.72878258
99Abnormality of oral frenula (HP:0000190)1.72656011
100Slender build (HP:0001533)1.71108874
101Pustule (HP:0200039)1.70003580
102Exostoses (HP:0100777)1.69687916
103Distal upper limb amyotrophy (HP:0007149)1.69419689
104Upper limb amyotrophy (HP:0009129)1.69419689
105Elfin facies (HP:0004428)1.69380378
106Cellulitis (HP:0100658)1.68911135
107Pseudobulbar signs (HP:0002200)1.68717656
108Broad palm (HP:0001169)1.68105857
109Thoracic kyphosis (HP:0002942)1.67537806
110Camptodactyly of toe (HP:0001836)1.67484792
111Myocardial infarction (HP:0001658)1.66829663
112Dislocated radial head (HP:0003083)1.66199380
113Trigonocephaly (HP:0000243)1.66004346
114Arterial thrombosis (HP:0004420)1.65642476
115Cutaneous melanoma (HP:0012056)1.65587330
116Papilloma (HP:0012740)1.64283347
117Verrucae (HP:0200043)1.64283347
118Loss of speech (HP:0002371)1.64106938
119Abnormal ossification of hand bones (HP:0005921)1.63834709
120Abnormality of the fingertips (HP:0001211)1.63341502
121Proximal placement of thumb (HP:0009623)1.62566432
122Lymphangioma (HP:0100764)1.62298151
123Cupped ribs (HP:0000887)1.62181752
124IgM deficiency (HP:0002850)1.62153312
125Gastrointestinal infarctions (HP:0005244)1.61907524
126Increased cerebral lipofuscin (HP:0011813)1.61453654
127Ectopia lentis (HP:0001083)1.61297231
128Mildly elevated creatine phosphokinase (HP:0008180)1.60606634
129Ankyloglossia (HP:0010296)1.60482494
130Orchitis (HP:0100796)1.60359945
131Viral hepatitis (HP:0006562)1.60087825
132Agammaglobulinemia (HP:0004432)1.59818275
133Autoimmune thrombocytopenia (HP:0001973)1.59783740
134Bowing of the arm (HP:0006488)1.59315839
135Bowed forearm bones (HP:0003956)1.59315839
136Spondylolisthesis (HP:0003302)1.59275847
137Wrist flexion contracture (HP:0001239)1.58944697
138Spinal rigidity (HP:0003306)1.58664408
139Mucopolysacchariduria (HP:0008155)1.57903089
140Urinary glycosaminoglycan excretion (HP:0003541)1.57903089
141Chronic otitis media (HP:0000389)1.57891819
142Joint laxity (HP:0001388)1.57664485
143Spastic diplegia (HP:0001264)1.56826938
144Abnormality of the radial head (HP:0003995)1.56633716
145Thin ribs (HP:0000883)1.56593951
146Ureteral stenosis (HP:0000071)1.56048599
147Wormian bones (HP:0002645)1.55783787
148Easy fatigability (HP:0003388)1.55538154
149Interstitial pulmonary disease (HP:0006530)1.55509120
150Short 5th finger (HP:0009237)1.54823277
151Mitral regurgitation (HP:0001653)1.53304177
152Hand muscle atrophy (HP:0009130)1.53296107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.60634048
2PKN23.93941631
3PRPF4B3.74132904
4EEF2K3.54490657
5SMG13.11021465
6MAP3K103.06403246
7MAP4K12.92592641
8STK102.34440526
9ERN12.18328709
10CDK122.16571180
11FGFR42.07070529
12LRRK21.98020720
13TTN1.95578374
14PTK61.94919605
15IRAK31.83246425
16PDGFRA1.70998740
17SIK11.69300767
18MAP3K131.61444430
19JAK31.59034689
20PAK41.56519003
21RIPK41.56389218
22ZAP701.54226081
23RIPK11.48767129
24CDC42BPA1.40389200
25TESK21.40085788
26BMX1.37738275
27EPHB11.32970923
28RPS6KA41.29891859
29CDK61.27508802
30MAP3K141.25088900
31FLT31.24519746
32SCYL21.21417355
33TXK1.19713156
34RPS6KB21.19627897
35EPHA31.19476463
36TAOK21.18910119
37MAP3K31.18800626
38GRK61.17416530
39EPHA21.16742822
40FGFR31.16509762
41NEK21.16230136
42ITK1.15950683
43TGFBR11.13290712
44CDC71.12247314
45TYK21.11973285
46TBK11.10707221
47IRAK41.09569639
48MARK21.08776232
49PRKD21.07257840
50KDR1.06028956
51PASK1.03623587
52MAP3K81.03335053
53SIK31.02922131
54CSK1.02522833
55PAK21.01209620
56ILK1.00980826
57ALK0.99249475
58MTOR0.97370794
59CDK40.97327949
60BTK0.97099849
61KSR20.96540821
62TGFBR20.95297861
63MST1R0.94175243
64PDGFRB0.90928419
65NEK90.89865648
66PTK20.89008615
67MAP2K30.88843308
68MAP3K10.87409655
69LATS10.87344401
70FGFR10.86866419
71KIT0.85320094
72TESK10.84307518
73CHUK0.84019406
74JAK10.83867619
75HCK0.82187630
76PIM10.78753727
77STK30.77816200
78HIPK20.77262459
79DDR20.77124808
80CSF1R0.76141016
81PDPK10.75045252
82BLK0.71779372
83TYRO30.70185892
84LCK0.69752505
85RPS6KA20.68625396
86MARK30.67426582
87FGR0.67007468
88DYRK1B0.66512309
89CDK70.65736783
90CLK10.64450966
91NME20.62583049
92MELK0.62035958
93TRPM70.60361705
94FES0.60277445
95PIM20.58603982
96DMPK0.57127951
97TNK20.56942914
98PDK10.56124016
99ICK0.55016959
100MAP2K20.54333627
101TSSK60.54127983
102CAMK1D0.53694202
103RET0.53655891
104MAPK70.51996800
105JAK20.51431259
106LMTK20.51420110
107PRKCH0.50956848
108LATS20.48314564
109MAP3K70.48116470
110ARAF0.47558371
111CAMKK10.46816511
112NLK0.46570942
113MAP3K110.46570866
114SIK20.45624603
115MOS0.44377972
116MAPKAPK20.44324094
117IRAK20.44247710
118TAOK10.42662607
119BRD40.41668809
120MAPK120.40794360
121MAPK110.40412118
122PRKD30.40057086
123STK40.39842943
124MAPKAPK30.38432987
125ATR0.37572791
126RPS6KA60.37127052
127AURKB0.35048810
128SYK0.34232675
129RPS6KL10.33664782
130RPS6KC10.33664782
131IKBKE0.33366751
132RPS6KA10.33260654
133PAK10.32567345
134CDK90.31984313

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.28528652
2Chronic myeloid leukemia_Homo sapiens_hsa052202.09664010
3Viral myocarditis_Homo sapiens_hsa054161.95261953
4Primary immunodeficiency_Homo sapiens_hsa053401.88010858
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86729302
6* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.85945385
7Antigen processing and presentation_Homo sapiens_hsa046121.84614081
8Small cell lung cancer_Homo sapiens_hsa052221.73154181
9Leishmaniasis_Homo sapiens_hsa051401.64189911
10T cell receptor signaling pathway_Homo sapiens_hsa046601.59732870
11Leukocyte transendothelial migration_Homo sapiens_hsa046701.59558591
12Acute myeloid leukemia_Homo sapiens_hsa052211.55371369
13Measles_Homo sapiens_hsa051621.54792134
14Pancreatic cancer_Homo sapiens_hsa052121.50324563
15Proteoglycans in cancer_Homo sapiens_hsa052051.49286938
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47628568
17DNA replication_Homo sapiens_hsa030301.47409183
18MicroRNAs in cancer_Homo sapiens_hsa052061.46540914
19Shigellosis_Homo sapiens_hsa051311.46263854
20Focal adhesion_Homo sapiens_hsa045101.45170035
21One carbon pool by folate_Homo sapiens_hsa006701.44496250
22Adherens junction_Homo sapiens_hsa045201.43446301
23Osteoclast differentiation_Homo sapiens_hsa043801.43270529
24Toxoplasmosis_Homo sapiens_hsa051451.42887083
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42499924
26HTLV-I infection_Homo sapiens_hsa051661.40329291
27Notch signaling pathway_Homo sapiens_hsa043301.37603191
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35540368
29Colorectal cancer_Homo sapiens_hsa052101.35274916
30Hepatitis B_Homo sapiens_hsa051611.34365423
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.33938241
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32923140
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32694664
34B cell receptor signaling pathway_Homo sapiens_hsa046621.27308816
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25746480
36Viral carcinogenesis_Homo sapiens_hsa052031.24820796
37p53 signaling pathway_Homo sapiens_hsa041151.24307299
38Apoptosis_Homo sapiens_hsa042101.23080165
39Cell cycle_Homo sapiens_hsa041101.20620932
40Bladder cancer_Homo sapiens_hsa052191.19581758
41Non-small cell lung cancer_Homo sapiens_hsa052231.16474097
42ECM-receptor interaction_Homo sapiens_hsa045121.15703838
43Legionellosis_Homo sapiens_hsa051341.15668851
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14923770
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.13645367
46Prion diseases_Homo sapiens_hsa050201.09991147
47Allograft rejection_Homo sapiens_hsa053301.07130323
48Central carbon metabolism in cancer_Homo sapiens_hsa052301.06092247
49TNF signaling pathway_Homo sapiens_hsa046681.06014247
50Platelet activation_Homo sapiens_hsa046111.05902174
51Herpes simplex infection_Homo sapiens_hsa051681.05157321
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.04235475
53ErbB signaling pathway_Homo sapiens_hsa040121.03187218
54Endometrial cancer_Homo sapiens_hsa052130.99488625
55Spliceosome_Homo sapiens_hsa030400.98697642
56Hematopoietic cell lineage_Homo sapiens_hsa046400.98187061
57Thyroid cancer_Homo sapiens_hsa052160.96981604
58VEGF signaling pathway_Homo sapiens_hsa043700.96410851
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.95769765
60Autoimmune thyroid disease_Homo sapiens_hsa053200.95283435
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.94820081
62Lysine degradation_Homo sapiens_hsa003100.94811492
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94369294
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94009451
65Amoebiasis_Homo sapiens_hsa051460.93580959
66mTOR signaling pathway_Homo sapiens_hsa041500.92640331
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92631583
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87657945
69Insulin signaling pathway_Homo sapiens_hsa049100.87249175
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87079393
71Base excision repair_Homo sapiens_hsa034100.86360861
72Malaria_Homo sapiens_hsa051440.86174860
73Insulin resistance_Homo sapiens_hsa049310.85466109
74Choline metabolism in cancer_Homo sapiens_hsa052310.84769266
75Hippo signaling pathway_Homo sapiens_hsa043900.84021669
76Prostate cancer_Homo sapiens_hsa052150.83870223
77RNA transport_Homo sapiens_hsa030130.83785389
78Pentose phosphate pathway_Homo sapiens_hsa000300.83267277
79Prolactin signaling pathway_Homo sapiens_hsa049170.81347122
80Endocytosis_Homo sapiens_hsa041440.80776574
81Staphylococcus aureus infection_Homo sapiens_hsa051500.80731454
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.80455042
83GnRH signaling pathway_Homo sapiens_hsa049120.80321250
84Epstein-Barr virus infection_Homo sapiens_hsa051690.80225250
85Pathways in cancer_Homo sapiens_hsa052000.79998610
86Lysosome_Homo sapiens_hsa041420.78598768
87HIF-1 signaling pathway_Homo sapiens_hsa040660.78269218
88Influenza A_Homo sapiens_hsa051640.78266750
89Basal cell carcinoma_Homo sapiens_hsa052170.77578303
90Inositol phosphate metabolism_Homo sapiens_hsa005620.77050221
91Mismatch repair_Homo sapiens_hsa034300.76888552
92Fructose and mannose metabolism_Homo sapiens_hsa000510.76841514
93Chemokine signaling pathway_Homo sapiens_hsa040620.75730694
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75727819
95Glioma_Homo sapiens_hsa052140.73493397
96Salmonella infection_Homo sapiens_hsa051320.72381076
97Estrogen signaling pathway_Homo sapiens_hsa049150.72349477
98Tuberculosis_Homo sapiens_hsa051520.71219705
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69943777
100TGF-beta signaling pathway_Homo sapiens_hsa043500.69087477
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67548370
102Renal cell carcinoma_Homo sapiens_hsa052110.66747911
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65819640
104Galactose metabolism_Homo sapiens_hsa000520.65422489
105Pertussis_Homo sapiens_hsa051330.65137386
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64460809
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62857304
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62202594
109mRNA surveillance pathway_Homo sapiens_hsa030150.61127756
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60785228
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60458816
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60333108
113Rap1 signaling pathway_Homo sapiens_hsa040150.58883104
114Hepatitis C_Homo sapiens_hsa051600.56520828
115FoxO signaling pathway_Homo sapiens_hsa040680.54688494
116Selenocompound metabolism_Homo sapiens_hsa004500.54474399
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54194810
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53262933
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.51225884
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51158936
121Adipocytokine signaling pathway_Homo sapiens_hsa049200.49779200
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47135120
123Graft-versus-host disease_Homo sapiens_hsa053320.45965511
124AMPK signaling pathway_Homo sapiens_hsa041520.44733778

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