SEPW1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.85915653
2synaptic vesicle docking involved in exocytosis (GO:0016081)5.55636596
3synaptic vesicle exocytosis (GO:0016079)5.53491680
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.40244800
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.28912453
6glutamate secretion (GO:0014047)5.24913530
7regulation of synaptic vesicle exocytosis (GO:2000300)4.92931785
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.82087725
9regulation of synapse structural plasticity (GO:0051823)4.77904402
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72207526
11locomotory exploration behavior (GO:0035641)4.71230400
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.69591385
13vocalization behavior (GO:0071625)4.66755554
14neuronal action potential propagation (GO:0019227)4.65648070
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.55595729
16ATP synthesis coupled proton transport (GO:0015986)4.51671676
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.51671676
18regulation of synaptic vesicle transport (GO:1902803)4.47941404
19protein localization to synapse (GO:0035418)4.42316464
20regulation of glutamate receptor signaling pathway (GO:1900449)4.41022951
21respiratory electron transport chain (GO:0022904)4.21769746
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.15837802
23electron transport chain (GO:0022900)4.15650154
24neurotransmitter secretion (GO:0007269)4.15605531
25regulation of neuronal synaptic plasticity (GO:0048168)4.05694809
26neurotransmitter-gated ion channel clustering (GO:0072578)4.00651693
27regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.88169590
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.83255880
29cellular potassium ion homeostasis (GO:0030007)3.79761842
30neuron cell-cell adhesion (GO:0007158)3.77011911
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76458501
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74013419
33exploration behavior (GO:0035640)3.71711725
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.62909331
35chaperone-mediated protein transport (GO:0072321)3.57526688
36muscle filament sliding (GO:0030049)3.53692236
37actin-myosin filament sliding (GO:0033275)3.53692236
38synaptic transmission, glutamatergic (GO:0035249)3.51145288
39activation of protein kinase A activity (GO:0034199)3.49719840
40negative regulation of microtubule polymerization (GO:0031115)3.44484078
41positive regulation of neurotransmitter transport (GO:0051590)3.42515248
42positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.41218256
43neuron-neuron synaptic transmission (GO:0007270)3.40912453
44positive regulation of synapse maturation (GO:0090129)3.40869219
45regulation of neurotransmitter secretion (GO:0046928)3.39172341
46regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.38780077
47negative regulation of dendrite morphogenesis (GO:0050774)3.37901322
48neuromuscular synaptic transmission (GO:0007274)3.36921840
49positive regulation of membrane potential (GO:0045838)3.36082926
50postsynaptic membrane organization (GO:0001941)3.35033351
51ionotropic glutamate receptor signaling pathway (GO:0035235)3.34416046
52regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.28521151
53regulation of synaptic plasticity (GO:0048167)3.26768978
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25966087
55central nervous system myelination (GO:0022010)3.24750420
56axon ensheathment in central nervous system (GO:0032291)3.24750420
57regulation of neurotransmitter transport (GO:0051588)3.22986239
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.22503277
59long-term memory (GO:0007616)3.21480939
60proline transport (GO:0015824)3.20205944
61establishment of protein localization to mitochondrial membrane (GO:0090151)3.19586296
62sodium ion export (GO:0071436)3.19214687
63cerebellar granule cell differentiation (GO:0021707)3.18663995
64regulation of vesicle fusion (GO:0031338)3.17080225
65positive regulation of neurotransmitter secretion (GO:0001956)3.15881570
66short-term memory (GO:0007614)3.14884888
67membrane depolarization during action potential (GO:0086010)3.14329523
68cell migration in hindbrain (GO:0021535)3.13810495
69layer formation in cerebral cortex (GO:0021819)3.13425987
70transmission of nerve impulse (GO:0019226)3.13346353
71regulation of voltage-gated calcium channel activity (GO:1901385)3.13164537
72neurotransmitter transport (GO:0006836)3.13097368
73regulation of postsynaptic membrane potential (GO:0060078)3.03568935
74auditory behavior (GO:0031223)3.03378956
75C4-dicarboxylate transport (GO:0015740)3.01770183
76long-term synaptic potentiation (GO:0060291)3.01001209
77negative regulation of dendrite development (GO:2000171)3.00087682
78protein complex biogenesis (GO:0070271)2.98928239
79sarcoplasmic reticulum calcium ion transport (GO:0070296)2.98527913
80regulation of neurotransmitter levels (GO:0001505)2.98473482
81response to auditory stimulus (GO:0010996)2.97467520
82hydrogen ion transmembrane transport (GO:1902600)2.95376902
83ATP biosynthetic process (GO:0006754)2.94807126
84synaptic vesicle endocytosis (GO:0048488)2.93782823
85transferrin transport (GO:0033572)2.92789491
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.92786295
87cerebellar Purkinje cell differentiation (GO:0021702)2.92498221
88positive regulation of synaptic transmission (GO:0050806)2.92060527
89ATP hydrolysis coupled proton transport (GO:0015991)2.90192659
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.90192659
91regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.89618877
92regulation of dendritic spine morphogenesis (GO:0061001)2.88132589
93presynaptic membrane organization (GO:0097090)2.88096263
94cell communication by electrical coupling (GO:0010644)2.87465890
95regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86522855
96negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.86296438
97negative regulation of calcium ion transmembrane transport (GO:1903170)2.86296438
98membrane depolarization (GO:0051899)2.86248936
99negative regulation of cation channel activity (GO:2001258)2.86247083
100glutamate receptor signaling pathway (GO:0007215)2.86081981
101presynaptic membrane assembly (GO:0097105)2.85793540
102adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.84978507
103neuromuscular process controlling balance (GO:0050885)2.84684126
104cell communication involved in cardiac conduction (GO:0086065)2.84275396
105behavioral response to nicotine (GO:0035095)2.83971711
106actin-mediated cell contraction (GO:0070252)2.82977929
107gamma-aminobutyric acid transport (GO:0015812)2.82740263
108cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81704774
109positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.81582490
110G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81110013
111negative regulation of heart rate (GO:0010459)2.80240352
112regulation of synaptic transmission (GO:0050804)2.79842969
113dopamine receptor signaling pathway (GO:0007212)2.79682159
114positive regulation of potassium ion transmembrane transport (GO:1901381)2.79632880
115neuromuscular process controlling posture (GO:0050884)2.78175527
116synaptic transmission (GO:0007268)2.78076326
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.76732328
118NADH dehydrogenase complex assembly (GO:0010257)2.76732328
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76732328
120protein neddylation (GO:0045116)2.75994701
121regulation of skeletal muscle contraction (GO:0014819)2.74963282
122negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74858067
123cellular sodium ion homeostasis (GO:0006883)2.73944106
124regulation of cell communication by electrical coupling (GO:0010649)2.73757107
125behavioral fear response (GO:0001662)2.72599107
126behavioral defense response (GO:0002209)2.72599107
127regulation of membrane repolarization (GO:0060306)2.72519481
128potassium ion import (GO:0010107)2.72235772
129regulation of ion transmembrane transporter activity (GO:0032412)2.72202721
130neurotransmitter uptake (GO:0001504)2.71856588
131prepulse inhibition (GO:0060134)2.71556846
132regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.71521191
133striated muscle contraction (GO:0006941)2.71226700
134striatum development (GO:0021756)2.70938262
135regulation of synapse maturation (GO:0090128)2.69914556
136synaptic vesicle transport (GO:0048489)2.69500614
137establishment of synaptic vesicle localization (GO:0097480)2.69500614
138calcium ion-dependent exocytosis (GO:0017156)2.68907161
139regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.68448906
140regulation of glutamate secretion (GO:0014048)2.68419988
141regulation of transmembrane transporter activity (GO:0022898)2.68419350
142regulation of sodium ion transmembrane transporter activity (GO:2000649)2.68140611
143potassium ion homeostasis (GO:0055075)2.68101331
144neuromuscular process (GO:0050905)2.67514892
145dendritic spine morphogenesis (GO:0060997)2.66357409
146neurofilament cytoskeleton organization (GO:0060052)2.64756115
147gamma-aminobutyric acid signaling pathway (GO:0007214)2.64657466
148cardiac muscle contraction (GO:0060048)2.64499975
149mitochondrial respiratory chain complex assembly (GO:0033108)2.62751132
150proton transport (GO:0015992)2.62392846
151detection of calcium ion (GO:0005513)2.60710197
152heart process (GO:0003015)2.60430055
153heart contraction (GO:0060047)2.60430055
154hydrogen transport (GO:0006818)2.58728627
155multicellular organismal signaling (GO:0035637)2.56760997
156negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.56553203
157regulation of relaxation of muscle (GO:1901077)2.55164541
158regulation of actin filament-based movement (GO:1903115)2.55019896
159purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.54343119
160cerebellar Purkinje cell layer development (GO:0021680)2.51477040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49936734
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.40748384
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16833812
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04858493
5* RARB_27405468_Chip-Seq_BRAIN_Mouse2.98158018
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.97784739
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90102808
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90102808
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.84442109
10REST_21632747_ChIP-Seq_MESCs_Mouse2.82293143
11GBX2_23144817_ChIP-Seq_PC3_Human2.80781002
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.70686339
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69979888
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.69892771
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.68459430
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.65358335
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.64282910
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.63742127
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54212570
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54168635
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.50585586
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.49503892
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.47517445
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.47269823
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.37090950
26DROSHA_22980978_ChIP-Seq_HELA_Human2.23554925
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.19672496
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17468850
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.16507084
30VDR_22108803_ChIP-Seq_LS180_Human2.01869302
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.90958701
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.86232817
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82744090
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73437229
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71514066
36AR_21572438_ChIP-Seq_LNCaP_Human1.64300756
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64010156
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59461700
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40443763
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37440648
41* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35960804
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34023921
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.33134626
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32986388
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32046018
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30483928
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29499046
48* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28924267
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.27534616
50CTCF_27219007_Chip-Seq_Bcells_Human1.25673950
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17890022
52KDM2B_26808549_Chip-Seq_K562_Human1.13601577
53SMAD4_21799915_ChIP-Seq_A2780_Human1.12998244
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12373699
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11172475
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05960784
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.05646602
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.04319350
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.03788443
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03611489
61TET1_21490601_ChIP-Seq_MESCs_Mouse1.03518183
62* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03151546
63TAF15_26573619_Chip-Seq_HEK293_Human1.02653384
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.02360295
65FUS_26573619_Chip-Seq_HEK293_Human1.02255671
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02237821
67ZNF274_21170338_ChIP-Seq_K562_Hela1.02060783
68RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01650556
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.01273682
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99735873
71CBX2_27304074_Chip-Seq_ESCs_Mouse0.99246194
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98818361
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97705341
74WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97548807
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96478634
76EP300_21415370_ChIP-Seq_HL-1_Mouse0.96428068
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95687468
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95624319
79AR_25329375_ChIP-Seq_VCAP_Human0.95404449
80* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95041601
81LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94040658
82RING1B_27294783_Chip-Seq_NPCs_Mouse0.93700831
83AR_19668381_ChIP-Seq_PC3_Human0.93163646
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93160546
85P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92487440
86HTT_18923047_ChIP-ChIP_STHdh_Human0.90531113
87IGF1R_20145208_ChIP-Seq_DFB_Human0.90365177
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90090524
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89925143
90P300_19829295_ChIP-Seq_ESCs_Human0.87439334
91SMC4_20622854_ChIP-Seq_HELA_Human0.86781905
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86680307
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86669780
94BCAT_22108803_ChIP-Seq_LS180_Human0.86348990
95SMAD_19615063_ChIP-ChIP_OVARY_Human0.86072726
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85891870
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85891870
98GATA1_26923725_Chip-Seq_HPCs_Mouse0.85490346
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85489415
100* LXR_22292898_ChIP-Seq_THP-1_Human0.85459503
101PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84514397
102OCT4_19829295_ChIP-Seq_ESCs_Human0.84033253
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83999892
104TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83975718
105GABP_17652178_ChIP-ChIP_JURKAT_Human0.83855444
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83159770
107ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82708572
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.82530814
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82354312
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81526087
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81474884
112TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.80916809
113EST1_17652178_ChIP-ChIP_JURKAT_Human0.80179507
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79872494
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79690176
116SMAD4_21741376_ChIP-Seq_ESCs_Human0.79210306
117KLF4_19829295_ChIP-Seq_ESCs_Human0.78210624
118KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.78152734
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77942278
120KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77602387
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77053103
122RNF2_27304074_Chip-Seq_NSC_Mouse0.76917946
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76302070
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.76184825
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75249517
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.75227368
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.74604260
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74029443
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73403248
130KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73322366
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.73298773
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73176015
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.72558703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.09654728
2MP0003880_abnormal_central_pattern3.94556778
3MP0004270_analgesia3.89485907
4MP0002822_catalepsy3.82694636
5MP0003635_abnormal_synaptic_transmissio3.72073241
6MP0001968_abnormal_touch/_nociception3.15512661
7MP0009745_abnormal_behavioral_response3.11677256
8MP0002063_abnormal_learning/memory/cond3.05394120
9MP0002064_seizures2.83334174
10MP0002734_abnormal_mechanical_nocicepti2.76131480
11MP0002735_abnormal_chemical_nociception2.65977101
12MP0002736_abnormal_nociception_after2.64426868
13MP0009046_muscle_twitch2.56269120
14MP0002572_abnormal_emotion/affect_behav2.51083349
15MP0004858_abnormal_nervous_system2.36937456
16MP0002272_abnormal_nervous_system2.35632911
17MP0002733_abnormal_thermal_nociception2.28072960
18MP0000751_myopathy2.27596580
19MP0009379_abnormal_foot_pigmentation2.26079449
20MP0001970_abnormal_pain_threshold2.21942155
21MP0005423_abnormal_somatic_nervous2.08959013
22MP0004145_abnormal_muscle_electrophysio2.06048950
23MP0008569_lethality_at_weaning1.99995313
24MP0000749_muscle_degeneration1.95199456
25MP0001486_abnormal_startle_reflex1.94232663
26MP0006276_abnormal_autonomic_nervous1.89046106
27MP0003646_muscle_fatigue1.88465070
28MP0001440_abnormal_grooming_behavior1.85791890
29MP0004811_abnormal_neuron_physiology1.81991672
30MP0002067_abnormal_sensory_capabilities1.77808451
31MP0003879_abnormal_hair_cell1.74492222
32MP0001501_abnormal_sleep_pattern1.73296204
33MP0002184_abnormal_innervation1.72487972
34MP0001529_abnormal_vocalization1.71588860
35MP0001905_abnormal_dopamine_level1.68339734
36MP0001485_abnormal_pinna_reflex1.67931952
37MP0005646_abnormal_pituitary_gland1.62434412
38MP0002909_abnormal_adrenal_gland1.61420084
39MP0005386_behavior/neurological_phenoty1.60576639
40MP0004924_abnormal_behavior1.60576639
41MP0002837_dystrophic_cardiac_calcinosis1.60540106
42MP0009780_abnormal_chondrocyte_physiolo1.60435372
43MP0002557_abnormal_social/conspecific_i1.56841849
44MP0003136_yellow_coat_color1.51793385
45MP0000955_abnormal_spinal_cord1.51750530
46MP0003122_maternal_imprinting1.48248061
47MP0000778_abnormal_nervous_system1.45850691
48MP0001984_abnormal_olfaction1.45104630
49MP0000013_abnormal_adipose_tissue1.43596165
50MP0003329_amyloid_beta_deposits1.40146835
51MP0004742_abnormal_vestibular_system1.35680923
52MP0002066_abnormal_motor_capabilities/c1.33520694
53MP0002882_abnormal_neuron_morphology1.30329916
54MP0003787_abnormal_imprinting1.29575135
55MP0003011_delayed_dark_adaptation1.29015695
56MP0004142_abnormal_muscle_tone1.28149942
57MP0004036_abnormal_muscle_relaxation1.23736210
58MP0010030_abnormal_orbit_morphology1.22619208
59MP0005551_abnormal_eye_electrophysiolog1.22168558
60MP0010386_abnormal_urinary_bladder1.20555329
61MP0003633_abnormal_nervous_system1.18256141
62MP0001502_abnormal_circadian_rhythm1.17231716
63MP0000566_synostosis1.14829774
64MP0008872_abnormal_physiological_respon1.10933978
65MP0004133_heterotaxia1.10189383
66MP0002638_abnormal_pupillary_reflex1.02920585
67MP0002653_abnormal_ependyma_morphology1.02597359
68MP0000747_muscle_weakness1.01345092
69MP0004233_abnormal_muscle_weight1.00708397
70MP0000759_abnormal_skeletal_muscle1.00587282
71MP0005620_abnormal_muscle_contractility1.00467988
72MP0005645_abnormal_hypothalamus_physiol0.99995641
73MP0001299_abnormal_eye_distance/0.99611670
74MP0003283_abnormal_digestive_organ0.96937222
75MP0003631_nervous_system_phenotype0.96928045
76MP0004147_increased_porphyrin_level0.96572728
77MP0003123_paternal_imprinting0.95073215
78MP0000750_abnormal_muscle_regeneration0.94609628
79MP0002106_abnormal_muscle_physiology0.93856715
80MP0006072_abnormal_retinal_apoptosis0.93104616
81MP0004085_abnormal_heartbeat0.92308769
82MP0008789_abnormal_olfactory_epithelium0.92080689
83MP0002069_abnormal_eating/drinking_beha0.90479573
84MP0000026_abnormal_inner_ear0.89253375
85MP0005394_taste/olfaction_phenotype0.88855288
86MP0005499_abnormal_olfactory_system0.88855288
87MP0004130_abnormal_muscle_cell0.87795378
88MP0004215_abnormal_myocardial_fiber0.86277343
89MP0002152_abnormal_brain_morphology0.85772780
90MP0004043_abnormal_pH_regulation0.85337621
91MP0008877_abnormal_DNA_methylation0.85091209
92MP0005330_cardiomyopathy0.84833476
93MP0004885_abnormal_endolymph0.84454488
94MP0002102_abnormal_ear_morphology0.82961019
95MP0005369_muscle_phenotype0.82266292
96MP0008874_decreased_physiological_sensi0.81234863
97MP0008775_abnormal_heart_ventricle0.79364515
98MP0002269_muscular_atrophy0.78382578
99MP0005253_abnormal_eye_physiology0.77867629
100MP0005535_abnormal_body_temperature0.77059370
101MP0004510_myositis0.76846838
102MP0003878_abnormal_ear_physiology0.75471312
103MP0005377_hearing/vestibular/ear_phenot0.75471312
104MP0004484_altered_response_of0.75077345
105MP0001986_abnormal_taste_sensitivity0.73607291
106MP0002751_abnormal_autonomic_nervous0.72915005
107MP0003075_altered_response_to0.72792380
108MP0003137_abnormal_impulse_conducting0.71665150
109MP0002229_neurodegeneration0.71598202
110MP0001188_hyperpigmentation0.71283643
111MP0004087_abnormal_muscle_fiber0.69700965
112MP0002972_abnormal_cardiac_muscle0.66333466
113MP0002752_abnormal_somatic_nervous0.66289236
114MP0002876_abnormal_thyroid_physiology0.63424234
115MP0003634_abnormal_glial_cell0.63309387
116MP0000534_abnormal_ureter_morphology0.62857503
117MP0006036_abnormal_mitochondrial_physio0.61465158
118MP0004084_abnormal_cardiac_muscle0.59204712
119MP0001963_abnormal_hearing_physiology0.58839816
120MP0008961_abnormal_basal_metabolism0.58426035
121MP0002332_abnormal_exercise_endurance0.58357828
122MP0001177_atelectasis0.57946928
123MP0001664_abnormal_digestion0.56447309
124MP0001943_abnormal_respiration0.54387469
125MP0006035_abnormal_mitochondrial_morpho0.53012712

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.84613968
2Focal motor seizures (HP:0011153)6.25584879
3Focal seizures (HP:0007359)4.31338282
4Epileptic encephalopathy (HP:0200134)4.21822898
5Visual hallucinations (HP:0002367)4.10184600
6Atonic seizures (HP:0010819)4.04891028
7Exercise-induced myalgia (HP:0003738)4.00846165
8Pheochromocytoma (HP:0002666)3.87128200
9Febrile seizures (HP:0002373)3.75047416
10Myotonia (HP:0002486)3.74893510
11Ankle clonus (HP:0011448)3.68046483
12Neuroendocrine neoplasm (HP:0100634)3.58126381
13Acute encephalopathy (HP:0006846)3.45768972
14Progressive cerebellar ataxia (HP:0002073)3.41814553
15Absence seizures (HP:0002121)3.20145766
16Limb dystonia (HP:0002451)3.11771521
17Anxiety (HP:0000739)3.11297957
18Action tremor (HP:0002345)3.10587246
19Generalized tonic-clonic seizures (HP:0002069)3.00997208
20Exercise-induced muscle cramps (HP:0003710)2.97727056
21Depression (HP:0000716)2.93810020
22Poor eye contact (HP:0000817)2.87828578
23Increased CSF lactate (HP:0002490)2.87239990
24Impaired vibration sensation in the lower limbs (HP:0002166)2.86390786
25Muscle fiber inclusion bodies (HP:0100299)2.85139488
26Broad-based gait (HP:0002136)2.83023220
27Focal dystonia (HP:0004373)2.82794306
28Dialeptic seizures (HP:0011146)2.81213144
29Abnormal eating behavior (HP:0100738)2.80573277
30Torticollis (HP:0000473)2.78085905
31Amblyopia (HP:0000646)2.74563289
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.73701771
33Nemaline bodies (HP:0003798)2.68368873
34Neoplasm of the peripheral nervous system (HP:0100007)2.67381389
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.64013899
36Hepatic necrosis (HP:0002605)2.62896348
37Supranuclear gaze palsy (HP:0000605)2.57967187
38Increased hepatocellular lipid droplets (HP:0006565)2.57853911
39Muscle hypertrophy of the lower extremities (HP:0008968)2.55779408
40Oligomenorrhea (HP:0000876)2.55693506
41Craniofacial dystonia (HP:0012179)2.52899474
42Abnormal ciliary motility (HP:0012262)2.50488443
43Failure to thrive in infancy (HP:0001531)2.50184079
44Annular pancreas (HP:0001734)2.47327269
45Muscle fiber splitting (HP:0003555)2.46987626
46Fetal akinesia sequence (HP:0001989)2.46644610
47Abnormal respiratory motile cilium physiology (HP:0012261)2.45618016
48Distal arthrogryposis (HP:0005684)2.44645709
49Calf muscle hypertrophy (HP:0008981)2.43491844
50Abnormal social behavior (HP:0012433)2.43389200
51Impaired social interactions (HP:0000735)2.43389200
52Urinary urgency (HP:0000012)2.42936513
53Poor suck (HP:0002033)2.41149957
54Urinary bladder sphincter dysfunction (HP:0002839)2.39393049
55Cerebral edema (HP:0002181)2.38498942
56Hyperventilation (HP:0002883)2.36631276
57Abnormal respiratory motile cilium morphology (HP:0005938)2.36180953
58Abnormal respiratory epithelium morphology (HP:0012253)2.36180953
59Abnormal hair whorl (HP:0010721)2.34866670
60Polyphagia (HP:0002591)2.33867614
61Progressive inability to walk (HP:0002505)2.32850820
62Megalencephaly (HP:0001355)2.32290388
63Abnormal mitochondria in muscle tissue (HP:0008316)2.32023920
64Increased intramyocellular lipid droplets (HP:0012240)2.31716577
65Sudden death (HP:0001699)2.29646319
66Spinal canal stenosis (HP:0003416)2.29502812
67EMG: myopathic abnormalities (HP:0003458)2.28968125
68Lipid accumulation in hepatocytes (HP:0006561)2.27905890
69Acute necrotizing encephalopathy (HP:0006965)2.26516060
70Abnormality of pain sensation (HP:0010832)2.25944593
71Impaired pain sensation (HP:0007328)2.25944593
72Bundle branch block (HP:0011710)2.24629830
73Hyporeflexia of lower limbs (HP:0002600)2.24212561
74Exercise intolerance (HP:0003546)2.21990483
75Leukodystrophy (HP:0002415)2.20353611
76Hypercortisolism (HP:0001578)2.19258236
77Abnormality of the lower motor neuron (HP:0002366)2.18630919
78Gaze-evoked nystagmus (HP:0000640)2.16283190
79Rhinitis (HP:0012384)2.16074312
80Dysmetria (HP:0001310)2.15349071
81Type 2 muscle fiber atrophy (HP:0003554)2.15348797
82Type 1 muscle fiber predominance (HP:0003803)2.15162293
83Delusions (HP:0000746)2.15003394
84Truncal ataxia (HP:0002078)2.14972803
85Abnormality of the calf musculature (HP:0001430)2.13802988
86Hypothermia (HP:0002045)2.13727151
87Syncope (HP:0001279)2.13403700
88Dynein arm defect of respiratory motile cilia (HP:0012255)2.12628388
89Absent/shortened dynein arms (HP:0200106)2.12628388
90Muscle stiffness (HP:0003552)2.12335706
91Ventricular fibrillation (HP:0001663)2.11219750
92Optic disc pallor (HP:0000543)2.06828689
93Respiratory failure (HP:0002878)2.06645717
94Renal Fanconi syndrome (HP:0001994)2.06530932
95Dysdiadochokinesis (HP:0002075)2.04921367
96Hypoventilation (HP:0002791)2.04204884
97Akinesia (HP:0002304)2.04017925
98Incomplete penetrance (HP:0003829)2.03475616
99Abnormal EKG (HP:0003115)2.03358686
100Myopathic facies (HP:0002058)2.02962448
101Shoulder girdle muscle weakness (HP:0003547)2.02269380
102Mutism (HP:0002300)2.01743750
103Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98420070
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98420070
105Progressive macrocephaly (HP:0004481)1.97513304
106Abnormality of the vocal cords (HP:0008777)1.96985968
107Cerebral hypomyelination (HP:0006808)1.96655275
108Left ventricular hypertrophy (HP:0001712)1.96360735
109Bradykinesia (HP:0002067)1.94763531
110Sleep apnea (HP:0010535)1.94732711
111Postural instability (HP:0002172)1.94603565
112Pancreatic fibrosis (HP:0100732)1.93738160
113True hermaphroditism (HP:0010459)1.92777905
114Lower limb muscle weakness (HP:0007340)1.92239667
115Lower limb amyotrophy (HP:0007210)1.91675403
116Popliteal pterygium (HP:0009756)1.91538047
117Increased muscle lipid content (HP:0009058)1.91448105
118Abnormality of the labia minora (HP:0012880)1.91130559
119Hepatocellular necrosis (HP:0001404)1.90970031
120Increased serum pyruvate (HP:0003542)1.90251725
121Increased variability in muscle fiber diameter (HP:0003557)1.90214297
122Atrial fibrillation (HP:0005110)1.89576341
123Spastic gait (HP:0002064)1.89544578
124Septo-optic dysplasia (HP:0100842)1.88669042
125Gait imbalance (HP:0002141)1.88640613
126Epileptiform EEG discharges (HP:0011182)1.88175777
127Hemiparesis (HP:0001269)1.87134109
128Mitochondrial inheritance (HP:0001427)1.87126797
129Stereotypic behavior (HP:0000733)1.86761711
130Resting tremor (HP:0002322)1.85812203
131Lactic acidosis (HP:0003128)1.85712410
132Impaired vibratory sensation (HP:0002495)1.84989817
133Muscle fiber atrophy (HP:0100295)1.84467926
134Abnormality of placental membranes (HP:0011409)1.84367156
135Amniotic constriction ring (HP:0009775)1.84367156
136Heart block (HP:0012722)1.83267399
137Specific learning disability (HP:0001328)1.82438535
138Menstrual irregularities (HP:0000858)1.82338440
139Generalized hypotonia (HP:0001290)1.82082107
140Abnormality of midbrain morphology (HP:0002418)1.82035468
141Molar tooth sign on MRI (HP:0002419)1.82035468
142Primary atrial arrhythmia (HP:0001692)1.81137045
143Obstructive sleep apnea (HP:0002870)1.81125264
144Prolonged QT interval (HP:0001657)1.81000893
145Inability to walk (HP:0002540)1.80532581
146Abnormality of skeletal muscle fiber size (HP:0012084)1.80101713
147Supraventricular tachycardia (HP:0004755)1.79337129
148Rigidity (HP:0002063)1.79074791
149Round ear (HP:0100830)1.75388887
150Supraventricular arrhythmia (HP:0005115)1.74465997
151Status epilepticus (HP:0002133)1.73630443
152Medial flaring of the eyebrow (HP:0010747)1.73567160
153Neck muscle weakness (HP:0000467)1.72350892

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.39316462
2NTRK33.18660766
3MAP3K123.13070100
4MAP3K92.90804991
5DAPK22.81842728
6MARK12.79104512
7CASK2.70266975
8MINK12.56765056
9ARAF2.34454904
10PHKG22.14916956
11PHKG12.14916956
12MAP2K72.08609341
13KSR22.05748505
14CDK192.03354109
15DAPK12.01333442
16MAP3K41.99769760
17LIMK11.98855247
18PRKD31.92193622
19VRK21.87251159
20PRPF4B1.86342934
21NTRK11.78043215
22GRK51.73954173
23TESK11.72631745
24PAK61.68600571
25SIK31.68593757
26NEK11.66159476
27CAMKK11.63417718
28PLK21.61816251
29NME11.55251513
30MAPK151.50361087
31MAP2K41.48465333
32NTRK21.41532818
33OBSCN1.39986139
34KSR11.38524210
35PAK31.35195185
36CDK51.34737314
37MAPK131.34453693
38PINK11.34409577
39STK161.29280646
40CAMKK21.29082090
41WNK31.22263421
42CCNB11.22155920
43SGK2231.17689376
44SGK4941.17689376
45TESK21.17394046
46TAOK11.16862906
47MAP4K21.14411606
48TIE11.13809010
49DAPK31.13774688
50PRKCG1.12886825
51CDK181.06595221
52UHMK11.04186225
53BMPR1B1.03274880
54CDK141.02793604
55PNCK1.00897460
56LMTK21.00430221
57CDK150.97962334
58EPHB20.97646051
59BRAF0.97636872
60PKN10.93905911
61MYLK0.93181365
62BCKDK0.88698078
63DMPK0.88188517
64SGK20.87978193
65CDK11A0.87682129
66PTK2B0.84228743
67MAP3K20.83374472
68LATS20.82615505
69PRKCH0.82512936
70MAPKAPK30.78773288
71GRK10.76939560
72CAMK2A0.76818222
73CAMK10.75360297
74FGFR20.75197393
75MUSK0.74142217
76SGK30.73681562
77MAP2K60.72181331
78CSNK1G30.71574672
79MST40.71458357
80INSRR0.71277894
81RAF10.70341754
82CAMK2B0.70139572
83MAP2K10.69961340
84CSNK1G10.69670653
85VRK10.69251569
86PRKG10.67050990
87RIPK40.65622045
88PDK20.63799131
89PBK0.63411951
90TRIB30.62756290
91PRKACA0.62432376
92ILK0.61357698
93CAMK2G0.60867668
94TLK10.59681491
95ROCK10.59462828
96STK390.58368694
97MAP3K10.58327257
98MAP3K110.57926012
99STK380.57394674
100RET0.57306261
101TSSK60.57298199
102ZAK0.56407005
103MAP3K130.55743497
104PIK3CA0.55544443
105ERBB30.55526743
106RPS6KA20.55316729
107DYRK1A0.54912703
108ADRBK20.54305948
109TYRO30.54207554
110SIK20.54080957
111PDK10.53992053
112PRKCE0.52325974
113PRKCA0.51719859
114TTN0.50724897
115MAPK120.50572186
116CAMK40.50407136
117CSNK1A1L0.49930108
118PDK40.49792685
119PDK30.49792685
120PDPK10.48986358
121PLK30.48933854
122STK110.47424571
123PRKG20.47260782
124DYRK20.45991389
125BMPR20.45113524
126TRIM280.44485841
127PRKCZ0.44216776
128BCR0.42988367
129TNK20.41338511
130BRSK10.40679704
131FES0.40245451
132ADRBK10.40216170
133SGK10.39091714
134TNIK0.37657581
135MARK20.37158357
136CAMK2D0.35912771
137OXSR10.35813086
138TAOK20.34656986
139CSNK1G20.33541104
140ROCK20.32590599
141MAPKAPK50.32010145

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.08115992
2Olfactory transduction_Homo sapiens_hsa047402.91711807
3Nicotine addiction_Homo sapiens_hsa050332.62038148
4Circadian entrainment_Homo sapiens_hsa047132.59238483
5GABAergic synapse_Homo sapiens_hsa047272.34560746
6Collecting duct acid secretion_Homo sapiens_hsa049662.30451467
7Long-term potentiation_Homo sapiens_hsa047202.28882069
8Amphetamine addiction_Homo sapiens_hsa050312.28166011
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.26028148
10Morphine addiction_Homo sapiens_hsa050322.21226290
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19934206
12Dopaminergic synapse_Homo sapiens_hsa047282.17290869
13Glutamatergic synapse_Homo sapiens_hsa047242.06698992
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.04813326
15Cholinergic synapse_Homo sapiens_hsa047251.97433096
16Insulin secretion_Homo sapiens_hsa049111.91524451
17Oxidative phosphorylation_Homo sapiens_hsa001901.84506725
18Parkinsons disease_Homo sapiens_hsa050121.82238829
19Cardiac muscle contraction_Homo sapiens_hsa042601.79746907
20Ribosome_Homo sapiens_hsa030101.77488805
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74590003
22Salivary secretion_Homo sapiens_hsa049701.69675975
23Gastric acid secretion_Homo sapiens_hsa049711.68341524
24Oxytocin signaling pathway_Homo sapiens_hsa049211.67619932
25Vibrio cholerae infection_Homo sapiens_hsa051101.60493286
26Cocaine addiction_Homo sapiens_hsa050301.59495566
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.56873336
28Nitrogen metabolism_Homo sapiens_hsa009101.55220937
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52637303
30Serotonergic synapse_Homo sapiens_hsa047261.49301852
31Calcium signaling pathway_Homo sapiens_hsa040201.48496410
32Long-term depression_Homo sapiens_hsa047301.47838921
33Alzheimers disease_Homo sapiens_hsa050101.42247163
34Taste transduction_Homo sapiens_hsa047421.36925470
35Renin secretion_Homo sapiens_hsa049241.35553295
36Gap junction_Homo sapiens_hsa045401.33384191
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30931196
38GnRH signaling pathway_Homo sapiens_hsa049121.28287110
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22356453
40Protein export_Homo sapiens_hsa030601.14320727
41Pyruvate metabolism_Homo sapiens_hsa006201.09452868
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07697582
43Huntingtons disease_Homo sapiens_hsa050161.06610159
44Arginine and proline metabolism_Homo sapiens_hsa003301.06335285
45Dilated cardiomyopathy_Homo sapiens_hsa054141.03515172
46Glioma_Homo sapiens_hsa052141.03421084
47Butanoate metabolism_Homo sapiens_hsa006501.03245544
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02762900
49RNA polymerase_Homo sapiens_hsa030201.01576987
50cAMP signaling pathway_Homo sapiens_hsa040241.01074232
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00959370
52Propanoate metabolism_Homo sapiens_hsa006400.99334424
53Fatty acid elongation_Homo sapiens_hsa000620.96564966
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95851018
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95485105
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95328501
57beta-Alanine metabolism_Homo sapiens_hsa004100.92783098
58Axon guidance_Homo sapiens_hsa043600.92593142
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.91295844
60Melanogenesis_Homo sapiens_hsa049160.91007124
61Histidine metabolism_Homo sapiens_hsa003400.89716393
62ErbB signaling pathway_Homo sapiens_hsa040120.87359761
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.84073146
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81477760
65Estrogen signaling pathway_Homo sapiens_hsa049150.81368759
66Oocyte meiosis_Homo sapiens_hsa041140.81319491
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80089513
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79135760
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79053168
70Folate biosynthesis_Homo sapiens_hsa007900.78951600
71Type II diabetes mellitus_Homo sapiens_hsa049300.78002707
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77349586
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75109387
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69982308
75Insulin signaling pathway_Homo sapiens_hsa049100.68951678
76Glucagon signaling pathway_Homo sapiens_hsa049220.67905257
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67338968
78VEGF signaling pathway_Homo sapiens_hsa043700.65890490
79Phototransduction_Homo sapiens_hsa047440.65030776
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62683467
81MAPK signaling pathway_Homo sapiens_hsa040100.62544146
82Rheumatoid arthritis_Homo sapiens_hsa053230.61325870
83Endocytosis_Homo sapiens_hsa041440.61234480
84Mineral absorption_Homo sapiens_hsa049780.61057283
85Vitamin B6 metabolism_Homo sapiens_hsa007500.60610828
86Phenylalanine metabolism_Homo sapiens_hsa003600.59394040
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58272951
88Sulfur relay system_Homo sapiens_hsa041220.58052486
89Circadian rhythm_Homo sapiens_hsa047100.57579571
90Tryptophan metabolism_Homo sapiens_hsa003800.57478259
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.56663127
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56662203
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56462531
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55779974
95Carbon metabolism_Homo sapiens_hsa012000.54933959
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54903176
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54893225
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54818377
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54166897
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53682025
101Peroxisome_Homo sapiens_hsa041460.52243176
102Fatty acid degradation_Homo sapiens_hsa000710.51896068
103Type I diabetes mellitus_Homo sapiens_hsa049400.50652588
104Phagosome_Homo sapiens_hsa041450.50652575
105Endometrial cancer_Homo sapiens_hsa052130.50312584
106Glutathione metabolism_Homo sapiens_hsa004800.50209167
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49984808
108Alcoholism_Homo sapiens_hsa050340.49649719
109Pancreatic secretion_Homo sapiens_hsa049720.48981062
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48522158
111Ras signaling pathway_Homo sapiens_hsa040140.48437487
112Metabolic pathways_Homo sapiens_hsa011000.47818940
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46084417
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45301445
115Rap1 signaling pathway_Homo sapiens_hsa040150.44470910
116Linoleic acid metabolism_Homo sapiens_hsa005910.43700837
117Arginine biosynthesis_Homo sapiens_hsa002200.43209436
118Prion diseases_Homo sapiens_hsa050200.42841484
119Non-small cell lung cancer_Homo sapiens_hsa052230.42682375
120Thyroid hormone synthesis_Homo sapiens_hsa049180.41584699
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41569177
122Regulation of autophagy_Homo sapiens_hsa041400.41289743
123Purine metabolism_Homo sapiens_hsa002300.40760306
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.40031478
125Chemical carcinogenesis_Homo sapiens_hsa052040.39959391
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39438027
127Bile secretion_Homo sapiens_hsa049760.38627183
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37578580
129Chemokine signaling pathway_Homo sapiens_hsa040620.35326656
130Renal cell carcinoma_Homo sapiens_hsa052110.33943777
131Choline metabolism in cancer_Homo sapiens_hsa052310.32692351
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31820080
133Proteasome_Homo sapiens_hsa030500.30484162
134mTOR signaling pathway_Homo sapiens_hsa041500.29740106
135Prolactin signaling pathway_Homo sapiens_hsa049170.29663185
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.29111174
137HIF-1 signaling pathway_Homo sapiens_hsa040660.28308499
138Fructose and mannose metabolism_Homo sapiens_hsa000510.27169240
139Tight junction_Homo sapiens_hsa045300.25922976

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