SEPW1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of heart rate (GO:0010459)5.53775070
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22115358
3ATP synthesis coupled proton transport (GO:0015986)5.22115358
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.17361694
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.93587066
6regulation of hypersensitivity (GO:0002883)4.79152985
7antigen processing and presentation via MHC class Ib (GO:0002475)4.68796916
8negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.56288491
9positive regulation of mast cell activation involved in immune response (GO:0033008)4.41862729
10positive regulation of mast cell degranulation (GO:0043306)4.41862729
11positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.35524947
12respiratory chain complex IV assembly (GO:0008535)4.20415737
13regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.99575710
14chaperone-mediated protein transport (GO:0072321)3.96841274
15positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.96604094
16respiratory electron transport chain (GO:0022904)3.94214057
17electron transport chain (GO:0022900)3.94031285
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.89768431
19regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.80348078
20positive regulation of mast cell activation (GO:0033005)3.78187278
21mast cell activation (GO:0045576)3.69289388
22cell wall macromolecule catabolic process (GO:0016998)3.68499081
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.61469574
24regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.58752962
25cytochrome complex assembly (GO:0017004)3.58019055
26peptidyl-histidine modification (GO:0018202)3.55967818
27hydrogen ion transmembrane transport (GO:1902600)3.53083836
28negative regulation of mast cell activation (GO:0033004)3.51762468
29centriole replication (GO:0007099)3.42192664
30regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.36486333
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.35401276
32mast cell degranulation (GO:0043303)3.33442065
33mast cell activation involved in immune response (GO:0002279)3.33442065
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32460846
35proton transport (GO:0015992)3.31456627
36sequestering of actin monomers (GO:0042989)3.26573811
37hydrogen transport (GO:0006818)3.26170727
38protein prenylation (GO:0018342)3.24704193
39prenylation (GO:0097354)3.24704193
40protein neddylation (GO:0045116)3.23093455
41L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22528590
42positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.21988549
43negative regulation of calcium ion transport into cytosol (GO:0010523)3.19349476
44positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.19285284
45mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.19285284
46signal peptide processing (GO:0006465)3.17899465
47cell wall macromolecule metabolic process (GO:0044036)3.16619840
48regulation of cellular amino acid metabolic process (GO:0006521)3.15269880
49protein refolding (GO:0042026)3.08160676
50regulation of interleukin-8 secretion (GO:2000482)3.07490715
51positive regulation of interleukin-1 beta secretion (GO:0050718)3.06889559
52negative regulation of growth of symbiont in host (GO:0044130)3.05701003
53negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.05701003
54modulation of growth of symbiont involved in interaction with host (GO:0044144)3.05701003
55regulation of growth of symbiont in host (GO:0044126)3.05701003
56positive regulation of histone H3-K4 methylation (GO:0051571)3.04547912
57ATP biosynthetic process (GO:0006754)3.02319202
58antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.98302671
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96851992
60protein localization to cilium (GO:0061512)2.95886090
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94185120
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94185120
63neutrophil activation involved in immune response (GO:0002283)2.93555178
64secretory granule organization (GO:0033363)2.92487022
65protein complex biogenesis (GO:0070271)2.92341811
66interferon-gamma-mediated signaling pathway (GO:0060333)2.91592465
67positive regulation of interleukin-1 secretion (GO:0050716)2.89901534
68membrane budding (GO:0006900)2.88086197
69purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86371594
70regulation of glucokinase activity (GO:0033131)2.84772470
71regulation of hexokinase activity (GO:1903299)2.84772470
72purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83961004
73DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82441855
74DNA deamination (GO:0045006)2.80308052
75immunoglobulin mediated immune response (GO:0016064)2.77866749
76mitochondrial respiratory chain complex I assembly (GO:0032981)2.76490921
77NADH dehydrogenase complex assembly (GO:0010257)2.76490921
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76490921
79amino acid salvage (GO:0043102)2.74986435
80L-methionine salvage (GO:0071267)2.74986435
81L-methionine biosynthetic process (GO:0071265)2.74986435
82positive regulation of cell cycle G1/S phase transition (GO:1902808)2.74694158
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74162017
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74162017
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73870033
86deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.73533071
87purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.73469270
88regulation of glomerular filtration (GO:0003093)2.72791595
89regulation of interleukin-1 beta secretion (GO:0050706)2.72040230
90positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.71545885
91histone H2A acetylation (GO:0043968)2.71321804
92regulation of mast cell activation (GO:0033003)2.69933901
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69541987
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69541987
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69541987
96histone mRNA metabolic process (GO:0008334)2.68808074
97regulation of inflammatory response to antigenic stimulus (GO:0002861)2.68259628
98negative regulation of cation channel activity (GO:2001258)2.67765799
99mitochondrial respiratory chain complex assembly (GO:0033108)2.66226557
100S-adenosylmethionine metabolic process (GO:0046500)2.65174373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.02594856
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.37839696
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54352493
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.37555801
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.35836082
6VDR_22108803_ChIP-Seq_LS180_Human3.16825538
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.63421786
8IGF1R_20145208_ChIP-Seq_DFB_Human2.54520206
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43390570
10VDR_23849224_ChIP-Seq_CD4+_Human2.37878729
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26211197
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.22177253
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.09869816
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09130461
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06310284
16P300_19829295_ChIP-Seq_ESCs_Human2.00900333
17ZNF274_21170338_ChIP-Seq_K562_Hela1.99420309
18ELK1_19687146_ChIP-ChIP_HELA_Human1.95805878
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.91904415
20TAF15_26573619_Chip-Seq_HEK293_Human1.91331928
21EWS_26573619_Chip-Seq_HEK293_Human1.85669176
22FOXP3_21729870_ChIP-Seq_TREG_Human1.85443563
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84066010
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83663217
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78012811
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77763485
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.71714300
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69542044
29GBX2_23144817_ChIP-Seq_PC3_Human1.67750679
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65140838
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61434846
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56857890
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56636836
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.55337912
35NANOG_19829295_ChIP-Seq_ESCs_Human1.53191758
36SOX2_19829295_ChIP-Seq_ESCs_Human1.53191758
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.51371774
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51371774
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50562292
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48229341
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.47566018
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43093175
43HTT_18923047_ChIP-ChIP_STHdh_Human1.38468725
44GATA3_26560356_Chip-Seq_TH2_Human1.38086512
45FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36719418
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35092028
47ERG_20517297_ChIP-Seq_VCAP_Human1.27963605
48RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26245120
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26038851
50TP53_22573176_ChIP-Seq_HFKS_Human1.24167047
51CIITA_25753668_ChIP-Seq_RAJI_Human1.23615716
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22553633
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21881663
54SALL4_22934838_ChIP-ChIP_CD34+_Human1.20772348
55SPI1_23547873_ChIP-Seq_NB4_Human1.20162597
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.18841643
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.18550191
58ELK1_22589737_ChIP-Seq_MCF10A_Human1.18548877
59FUS_26573619_Chip-Seq_HEK293_Human1.17933031
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17857248
61CBP_20019798_ChIP-Seq_JUKART_Human1.17857248
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16578093
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16216935
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15883802
65AR_20517297_ChIP-Seq_VCAP_Human1.14617474
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13894688
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13596414
68GATA3_26560356_Chip-Seq_TH1_Human1.13568438
69BCAT_22108803_ChIP-Seq_LS180_Human1.13023689
70DCP1A_22483619_ChIP-Seq_HELA_Human1.12224665
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09466275
72MYC_18940864_ChIP-ChIP_HL60_Human1.08351311
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06021328
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05784096
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04918939
76MYB_26560356_Chip-Seq_TH2_Human1.04584359
77AR_25329375_ChIP-Seq_VCAP_Human1.04382220
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04260055
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.03529624
80RBPJ_21746931_ChIP-Seq_IB4_Human1.01596948
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01593971
82ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01351028
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00917063
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99911641
85CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99356482
86MYC_18555785_ChIP-Seq_MESCs_Mouse0.98383459
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.97671546
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97262384
89E2F4_17652178_ChIP-ChIP_JURKAT_Human0.95191197
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92989874
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.92833451
92IRF8_27001747_Chip-Seq_BMDM_Mouse0.92533145
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.90224340
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89158868
95FLI1_21867929_ChIP-Seq_TH2_Mouse0.88846227
96ETV1_20927104_ChIP-Seq_GIST48_Human0.88032979
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.87530111
98P53_22387025_ChIP-Seq_ESCs_Mouse0.87515205
99NCOR_22424771_ChIP-Seq_293T_Human0.87305308
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87287032

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.39376895
2MP0002166_altered_tumor_susceptibility3.19919371
3MP0003880_abnormal_central_pattern3.12448690
4MP0003183_abnormal_peptide_metabolism3.11141077
5MP0009785_altered_susceptibility_to3.01508847
6MP0005671_abnormal_response_to2.92105170
7MP0003806_abnormal_nucleotide_metabolis2.81734246
8MP0009379_abnormal_foot_pigmentation2.79846593
9MP0006072_abnormal_retinal_apoptosis2.54488531
10MP0002006_tumorigenesis2.33179886
11MP0009764_decreased_sensitivity_to2.32793675
12MP0003724_increased_susceptibility_to2.22832278
13MP0002837_dystrophic_cardiac_calcinosis2.21705769
14MP0001905_abnormal_dopamine_level2.06074592
15MP0000516_abnormal_urinary_system2.06037690
16MP0005367_renal/urinary_system_phenotyp2.06037690
17MP0001853_heart_inflammation2.05121526
18MP0006036_abnormal_mitochondrial_physio1.98126407
19MP0001800_abnormal_humoral_immune1.92966440
20MP0002148_abnormal_hypersensitivity_rea1.82294579
21MP0005645_abnormal_hypothalamus_physiol1.71393432
22MP0005075_abnormal_melanosome_morpholog1.67436603
23MP0003283_abnormal_digestive_organ1.64809052
24MP0000858_altered_metastatic_potential1.64396359
25MP0005253_abnormal_eye_physiology1.63388147
26MP0004742_abnormal_vestibular_system1.61987035
27MP0001529_abnormal_vocalization1.57243841
28MP0000372_irregular_coat_pigmentation1.52973195
29MP0008875_abnormal_xenobiotic_pharmacok1.52232784
30MP0003186_abnormal_redox_activity1.51679887
31MP0004142_abnormal_muscle_tone1.50805022
32MP0002102_abnormal_ear_morphology1.48437180
33MP0002736_abnormal_nociception_after1.46505384
34MP0003866_abnormal_defecation1.43633639
35MP0002452_abnormal_antigen_presenting1.43088322
36MP0002723_abnormal_immune_serum1.41722500
37MP0001986_abnormal_taste_sensitivity1.38128144
38MP0005000_abnormal_immune_tolerance1.37579250
39MP0009046_muscle_twitch1.35835232
40MP0000685_abnormal_immune_system1.35189553
41MP0002419_abnormal_innate_immunity1.32399141
42MP0002638_abnormal_pupillary_reflex1.29820994
43MP0002272_abnormal_nervous_system1.28508306
44MP0005085_abnormal_gallbladder_physiolo1.28329581
45MP0006035_abnormal_mitochondrial_morpho1.26978786
46MP0004147_increased_porphyrin_level1.24873971
47MP0001188_hyperpigmentation1.23619332
48MP0001542_abnormal_bone_strength1.22345534
49MP0006276_abnormal_autonomic_nervous1.18515330
50MP0002876_abnormal_thyroid_physiology1.18270681
51MP0010155_abnormal_intestine_physiology1.17958220
52MP0008469_abnormal_protein_level1.16307407
53MP0005408_hypopigmentation1.14320628
54MP0002420_abnormal_adaptive_immunity1.14040964
55MP0001873_stomach_inflammation1.13237225
56MP0001819_abnormal_immune_cell1.12923993
57MP0003252_abnormal_bile_duct1.11094417
58MP0005025_abnormal_response_to1.10106839
59MP0005636_abnormal_mineral_homeostasis1.08689495
60MP0005535_abnormal_body_temperature1.06381822
61MP0005551_abnormal_eye_electrophysiolog1.05212427
62MP0003787_abnormal_imprinting1.03554869
63MP0001756_abnormal_urination1.03516219
64MP0003195_calcinosis1.01791760
65MP0001845_abnormal_inflammatory_respons0.99367410
66MP0003075_altered_response_to0.95484270
67MP0003718_maternal_effect0.95097721
68MP0005451_abnormal_body_composition0.93168217
69MP0001968_abnormal_touch/_nociception0.91532953
70MP0008872_abnormal_physiological_respon0.90905842
71MP0009745_abnormal_behavioral_response0.89606931
72MP0006082_CNS_inflammation0.89472209
73MP0001501_abnormal_sleep_pattern0.88228397
74MP0008995_early_reproductive_senescence0.87390817
75MP0001790_abnormal_immune_system0.87116494
76MP0005387_immune_system_phenotype0.87116494
77MP0002751_abnormal_autonomic_nervous0.86414472
78MP0002009_preneoplasia0.85713498
79MP0005166_decreased_susceptibility_to0.84503233
80MP0002163_abnormal_gland_morphology0.84360603
81MP0009763_increased_sensitivity_to0.83152019
82MP0004215_abnormal_myocardial_fiber0.81202099
83MP0001486_abnormal_startle_reflex0.78838845
84MP0001970_abnormal_pain_threshold0.78475646
85MP0003878_abnormal_ear_physiology0.77416945
86MP0005377_hearing/vestibular/ear_phenot0.77416945
87MP0005332_abnormal_amino_acid0.76220708
88MP0002693_abnormal_pancreas_physiology0.75895203
89MP0004883_abnormal_blood_vessel0.75168677
90MP0005379_endocrine/exocrine_gland_phen0.74654384
91MP0001545_abnormal_hematopoietic_system0.73143308
92MP0005397_hematopoietic_system_phenotyp0.73143308
93MP0003786_premature_aging0.72670821
94MP0005266_abnormal_metabolism0.72511761
95MP0000383_abnormal_hair_follicle0.72003433
96MP0000716_abnormal_immune_system0.67847249
97MP0005360_urolithiasis0.67784251
98MP0003638_abnormal_response/metabolism_0.67104206
99MP0005174_abnormal_tail_pigmentation0.66074733
100MP0003137_abnormal_impulse_conducting0.65235894

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)4.98215212
2Hyperalaninemia (HP:0003348)4.98215212
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.98215212
43-Methylglutaconic aciduria (HP:0003535)4.53644267
5Aplastic anemia (HP:0001915)4.21992151
6Acute necrotizing encephalopathy (HP:0006965)4.03355680
7Generalized aminoaciduria (HP:0002909)3.86348761
8Recurrent cutaneous fungal infections (HP:0011370)3.85679149
9Chronic mucocutaneous candidiasis (HP:0002728)3.85679149
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.85488786
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.85488786
12Renal cortical cysts (HP:0000803)3.80323133
13Progressive macrocephaly (HP:0004481)3.60394850
14Microretrognathia (HP:0000308)3.54858815
15Hepatic necrosis (HP:0002605)3.48528273
16Elevated erythrocyte sedimentation rate (HP:0003565)3.33125269
17Mitochondrial inheritance (HP:0001427)3.31414793
18Hepatocellular necrosis (HP:0001404)3.29021116
19Abnormal mitochondria in muscle tissue (HP:0008316)3.28992504
20Congenital, generalized hypertrichosis (HP:0004540)3.19124521
21Hypoproteinemia (HP:0003075)3.17195170
22Acute encephalopathy (HP:0006846)3.04045736
23Increased CSF lactate (HP:0002490)3.02307986
24Facial diplegia (HP:0001349)2.99385805
25Panhypogammaglobulinemia (HP:0003139)2.77453279
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.75994878
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.71013451
28Absent/shortened dynein arms (HP:0200106)2.71013451
29Cerebral edema (HP:0002181)2.68300450
30Methylmalonic acidemia (HP:0002912)2.64520378
31Lactic acidosis (HP:0003128)2.58676298
32Increased hepatocellular lipid droplets (HP:0006565)2.49183756
33Optic disc pallor (HP:0000543)2.43717174
34Amyotrophic lateral sclerosis (HP:0007354)2.43666687
35Agammaglobulinemia (HP:0004432)2.41667002
36Abnormality of midbrain morphology (HP:0002418)2.37930552
37Molar tooth sign on MRI (HP:0002419)2.37930552
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36127431
39Petechiae (HP:0000967)2.35822263
40Metaphyseal dysplasia (HP:0100255)2.35275690
41Decreased central vision (HP:0007663)2.34408769
42Type 2 muscle fiber atrophy (HP:0003554)2.34323050
43Abnormality of the renal cortex (HP:0011035)2.32973305
44IgG deficiency (HP:0004315)2.32296537
45Increased serum lactate (HP:0002151)2.31120090
46Ureteral stenosis (HP:0000071)2.30749463
47Leukodystrophy (HP:0002415)2.30236172
48Hypothermia (HP:0002045)2.30160869
49Congenital stationary night blindness (HP:0007642)2.29593373
50Abolished electroretinogram (ERG) (HP:0000550)2.26110448
51Recurrent bronchitis (HP:0002837)2.25418481
52Acute hepatic failure (HP:0006554)2.23768316
53Abnormality of the basal ganglia (HP:0002134)2.22405909
54Prolonged neonatal jaundice (HP:0006579)2.22280383
55Abnormality of the prostate (HP:0008775)2.21916047
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20996356
57Gangrene (HP:0100758)2.16537894
58Lipid accumulation in hepatocytes (HP:0006561)2.15775359
59Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15631038
60Recurrent skin infections (HP:0001581)2.09102993
61Chronic sinusitis (HP:0011109)2.08998006
62Ureteral obstruction (HP:0006000)2.08304406
63Dyskinesia (HP:0100660)2.06467850
64Hemoptysis (HP:0002105)2.03657029
65Spastic paraparesis (HP:0002313)2.03109987
66Alveolar cell carcinoma (HP:0006519)2.02956632
67Recurrent gram-negative bacterial infections (HP:0005420)1.99570764
68Obstructive lung disease (HP:0006536)1.97670242
69Chronic obstructive pulmonary disease (HP:0006510)1.97670242
70Short middle phalanx of the 5th finger (HP:0004220)1.94627488
71Abnormal rod and cone electroretinograms (HP:0008323)1.93576867
72Bronchitis (HP:0012387)1.92259645
73Recurrent fungal infections (HP:0002841)1.90892365
74Exertional dyspnea (HP:0002875)1.90690892
75Retinal dysplasia (HP:0007973)1.88792779
76Central scotoma (HP:0000603)1.88650375
77Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88138976
78Dicarboxylic aciduria (HP:0003215)1.88138976
79Respiratory failure (HP:0002878)1.85829016
80Basal ganglia calcification (HP:0002135)1.85669109
81Flat capital femoral epiphysis (HP:0003370)1.84283259
82Neoplasm of the tracheobronchial system (HP:0100552)1.83235878
83Nemaline bodies (HP:0003798)1.82063546
84Abnormality of serum amino acid levels (HP:0003112)1.79829214
85Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79328674
86Methylmalonic aciduria (HP:0012120)1.78594940
87Aplasia/Hypoplasia of the clavicles (HP:0006710)1.78502529
88Cleft eyelid (HP:0000625)1.77278670
89Abnormality of dental color (HP:0011073)1.77040858
90Abnormality of the pleura (HP:0002103)1.74455175
91Muscle fiber atrophy (HP:0100295)1.74225033
92Abnormality of secondary sexual hair (HP:0009888)1.73920416
93Abnormality of the axillary hair (HP:0100134)1.73920416
94Chronic diarrhea (HP:0002028)1.73515034
95Renal Fanconi syndrome (HP:0001994)1.73357913
96Abnormality of macular pigmentation (HP:0008002)1.72956248
97Porencephaly (HP:0002132)1.71730051
98Stenosis of the external auditory canal (HP:0000402)1.71490623
99Neonatal respiratory distress (HP:0002643)1.71425816
100Short tibia (HP:0005736)1.70174866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR26.12820320
2CDK195.02660423
3MAP4K24.07280000
4MAP3K123.15037964
5ERBB32.74545291
6EPHA32.49164485
7NUAK12.35409637
8TXK2.24334950
9TLK12.11756701
10BCKDK2.06151743
11RPS6KA42.05699305
12FLT31.85087023
13TRPM71.84113207
14CSNK1G21.78766038
15MYLK1.78589895
16CSF1R1.77345214
17TAOK31.73979203
18CDK81.70512605
19OXSR11.65978740
20PINK11.62959542
21CSNK1G31.53926251
22KIT1.53614773
23WNK31.47253018
24DYRK21.46832884
25MAP3K41.39528592
26RIPK41.37020775
27CSNK1A1L1.29908435
28MST41.20353555
29GRK11.19753427
30CSNK1G11.12461021
31KDR1.11443427
32IKBKB1.08952999
33RPS6KA51.01549744
34MAP2K70.94478596
35SIK30.92052388
36PRKCE0.91069116
37ILK0.89549770
38MKNK10.86974413
39SCYL20.84632904
40ADRBK20.83667469
41INSRR0.80919863
42VRK10.80490904
43TEC0.76915883
44STK160.76064283
45FRK0.74447113
46UHMK10.72262650
47CCNB10.72062077
48DYRK30.66089810
49MUSK0.65817158
50OBSCN0.65650378
51SRPK10.62535866
52ABL20.60205618
53DAPK10.59938871
54CAMK2D0.59653234
55MAPK130.59372041
56MARK30.58429468
57BTK0.56396924
58EGFR0.56019244
59BLK0.54918651
60ITK0.54668668
61WNK10.51530396
62PRKG10.51112721
63LYN0.50799527
64MINK10.50441346
65ABL10.49129036
66FGFR10.48696968
67SYK0.47307393
68DAPK30.46327390
69TNIK0.45008538
70NME10.44868408
71WNK40.44791121
72PLK20.44618067
73CSNK2A10.43792882
74EPHA40.43594234
75LCK0.43505829
76HCK0.42507651
77PAK40.42321859
78CAMK2A0.40077582
79MAP3K140.39899602
80SIK20.38591829
81TIE10.36802694
82CSNK1A10.36748306
83PRKACA0.36426933
84IGF1R0.36090765
85PTK2B0.35969811
86IKBKE0.35826000
87CSNK2A20.34270993
88PRKCB0.33160888
89PAK10.32968241
90CHUK0.32447024
91CDK140.30773471
92JAK30.30040672
93PHKG10.29749010
94PHKG20.29749010
95CSNK1D0.28998292
96PRKACG0.28882302
97PRKCA0.28824425
98CAMK2B0.28156617
99BCR0.27135926
100HIPK20.26621396

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.92211711
2Allograft rejection_Homo sapiens_hsa053303.93200798
3Autoimmune thyroid disease_Homo sapiens_hsa053203.81216429
4Graft-versus-host disease_Homo sapiens_hsa053323.77034690
5Type I diabetes mellitus_Homo sapiens_hsa049403.42138157
6Oxidative phosphorylation_Homo sapiens_hsa001903.26184100
7Proteasome_Homo sapiens_hsa030503.23306163
8Intestinal immune network for IgA production_Homo sapiens_hsa046723.18865202
9Antigen processing and presentation_Homo sapiens_hsa046123.00903306
10Protein export_Homo sapiens_hsa030602.67141833
11Parkinsons disease_Homo sapiens_hsa050122.57287359
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.34993980
13Viral myocarditis_Homo sapiens_hsa054162.13135021
14Ribosome_Homo sapiens_hsa030102.06953968
15Rheumatoid arthritis_Homo sapiens_hsa053232.06652143
16Staphylococcus aureus infection_Homo sapiens_hsa051502.05392556
17Leishmaniasis_Homo sapiens_hsa051401.68715082
18Alzheimers disease_Homo sapiens_hsa050101.64104501
19Cardiac muscle contraction_Homo sapiens_hsa042601.62690665
20Huntingtons disease_Homo sapiens_hsa050161.56648554
21Collecting duct acid secretion_Homo sapiens_hsa049661.44098104
22RNA polymerase_Homo sapiens_hsa030201.38984049
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30515992
24Systemic lupus erythematosus_Homo sapiens_hsa053221.28441043
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25340878
26RNA degradation_Homo sapiens_hsa030181.22266826
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11722813
28Hematopoietic cell lineage_Homo sapiens_hsa046401.01235667
29Regulation of autophagy_Homo sapiens_hsa041400.98134911
30Phototransduction_Homo sapiens_hsa047440.95917484
31One carbon pool by folate_Homo sapiens_hsa006700.95681258
32Primary immunodeficiency_Homo sapiens_hsa053400.88834777
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87838097
34Phagosome_Homo sapiens_hsa041450.86986337
35DNA replication_Homo sapiens_hsa030300.86310862
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82065806
37Tuberculosis_Homo sapiens_hsa051520.79918406
38Propanoate metabolism_Homo sapiens_hsa006400.76201181
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71502115
40Toxoplasmosis_Homo sapiens_hsa051450.68781659
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68590749
42Spliceosome_Homo sapiens_hsa030400.68177691
43Sulfur metabolism_Homo sapiens_hsa009200.66156670
44Tryptophan metabolism_Homo sapiens_hsa003800.58828595
45Pyrimidine metabolism_Homo sapiens_hsa002400.56333169
46Linoleic acid metabolism_Homo sapiens_hsa005910.53449182
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53112740
48Mismatch repair_Homo sapiens_hsa034300.52864415
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51931617
50RNA transport_Homo sapiens_hsa030130.50704574
51Salmonella infection_Homo sapiens_hsa051320.50625156
52Chemical carcinogenesis_Homo sapiens_hsa052040.49507976
53Shigellosis_Homo sapiens_hsa051310.49078366
54Epstein-Barr virus infection_Homo sapiens_hsa051690.47204092
55Nitrogen metabolism_Homo sapiens_hsa009100.47202479
56GABAergic synapse_Homo sapiens_hsa047270.46905560
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45571823
58Nucleotide excision repair_Homo sapiens_hsa034200.45043116
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44384390
60Ether lipid metabolism_Homo sapiens_hsa005650.43781852
61Arachidonic acid metabolism_Homo sapiens_hsa005900.43230783
62Salivary secretion_Homo sapiens_hsa049700.43141344
63Pertussis_Homo sapiens_hsa051330.42281796
64Basal transcription factors_Homo sapiens_hsa030220.41772896
65Serotonergic synapse_Homo sapiens_hsa047260.41426895
66Homologous recombination_Homo sapiens_hsa034400.41322300
67Herpes simplex infection_Homo sapiens_hsa051680.40409225
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40181580
69Purine metabolism_Homo sapiens_hsa002300.40130073
70Legionellosis_Homo sapiens_hsa051340.40124770
71Peroxisome_Homo sapiens_hsa041460.39432660
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38922294
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38611674
74Influenza A_Homo sapiens_hsa051640.35304387
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34926986
76Metabolic pathways_Homo sapiens_hsa011000.34229378
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.33195315
78Olfactory transduction_Homo sapiens_hsa047400.31774752
79Glutathione metabolism_Homo sapiens_hsa004800.30323543
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29382808
81Butanoate metabolism_Homo sapiens_hsa006500.29160745
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29051313
83Renin-angiotensin system_Homo sapiens_hsa046140.27887747
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27603215
85Fanconi anemia pathway_Homo sapiens_hsa034600.26937177
86Vibrio cholerae infection_Homo sapiens_hsa051100.25832924
87Morphine addiction_Homo sapiens_hsa050320.25505529
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25377199
89Taste transduction_Homo sapiens_hsa047420.24751491
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24567428
91Circadian entrainment_Homo sapiens_hsa047130.23426653
92Pyruvate metabolism_Homo sapiens_hsa006200.22593865
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.21783697
94Folate biosynthesis_Homo sapiens_hsa007900.21690318
95Non-homologous end-joining_Homo sapiens_hsa034500.20990787
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20518789
97Synaptic vesicle cycle_Homo sapiens_hsa047210.20094495
98beta-Alanine metabolism_Homo sapiens_hsa004100.19766432
99Fatty acid elongation_Homo sapiens_hsa000620.19280542
100Circadian rhythm_Homo sapiens_hsa047100.17775282

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