SERAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a phosphatidylglycerol remodeling protein found at the interface of mitochondria and endoplasmic reticula, where it mediates phospholipid exchange. The encoded protein plays a major role in mitochondrial function and intracellular cholesterol trafficking. Defects in this gene are a cause of 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.25491263
2central nervous system myelination (GO:0022010)4.71782284
3axon ensheathment in central nervous system (GO:0032291)4.71782284
4sulfation (GO:0051923)4.34774009
5vocalization behavior (GO:0071625)4.31736674
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.04637028
7cerebral cortex radially oriented cell migration (GO:0021799)4.00501284
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.98613876
9ionotropic glutamate receptor signaling pathway (GO:0035235)3.93967418
10kynurenine metabolic process (GO:0070189)3.91493100
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.87636966
12indole-containing compound catabolic process (GO:0042436)3.87101801
13indolalkylamine catabolic process (GO:0046218)3.87101801
14tryptophan catabolic process (GO:0006569)3.87101801
15presynaptic membrane organization (GO:0097090)3.82968136
16indolalkylamine metabolic process (GO:0006586)3.80692429
17neuron cell-cell adhesion (GO:0007158)3.79323426
18cerebellar granule cell differentiation (GO:0021707)3.76388439
19presynaptic membrane assembly (GO:0097105)3.75327584
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74405006
21tryptophan metabolic process (GO:0006568)3.68531803
22water-soluble vitamin biosynthetic process (GO:0042364)3.65820271
23protein localization to synapse (GO:0035418)3.60565022
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50600024
25negative regulation of transcription regulatory region DNA binding (GO:2000678)3.49793886
26regulation of glutamate receptor signaling pathway (GO:1900449)3.47177360
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.46313505
28glutamate receptor signaling pathway (GO:0007215)3.45331844
29negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42033693
30protein polyglutamylation (GO:0018095)3.39487989
31synaptic vesicle endocytosis (GO:0048488)3.37707441
32synaptic vesicle exocytosis (GO:0016079)3.37586109
33synaptic transmission, glutamatergic (GO:0035249)3.35788764
34locomotory exploration behavior (GO:0035641)3.34016645
35startle response (GO:0001964)3.32374363
36L-amino acid import (GO:0043092)3.31224844
37retinal cone cell development (GO:0046549)3.29267371
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28157187
39negative regulation of mast cell activation (GO:0033004)3.28051528
40negative regulation of systemic arterial blood pressure (GO:0003085)3.26964074
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26455536
42cerebellar Purkinje cell differentiation (GO:0021702)3.24475084
43cell proliferation in forebrain (GO:0021846)3.24234895
44platelet dense granule organization (GO:0060155)3.22429662
45neuron-neuron synaptic transmission (GO:0007270)3.22115141
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.21300071
47NADH dehydrogenase complex assembly (GO:0010257)3.21300071
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21300071
49behavioral response to ethanol (GO:0048149)3.20235425
50fat-soluble vitamin catabolic process (GO:0042363)3.15981719
51vitamin catabolic process (GO:0009111)3.15981719
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15206978
53adult walking behavior (GO:0007628)3.11047002
54synaptic vesicle maturation (GO:0016188)3.10653972
55regulation of synapse maturation (GO:0090128)3.06951764
56indole-containing compound metabolic process (GO:0042430)3.06059686
57response to pheromone (GO:0019236)3.04167715
58dendritic spine morphogenesis (GO:0060997)3.03793222
59regulation of gene silencing by RNA (GO:0060966)3.02579878
60regulation of posttranscriptional gene silencing (GO:0060147)3.02579878
61regulation of gene silencing by miRNA (GO:0060964)3.02579878
62histone H3-K4 trimethylation (GO:0080182)3.02112973
63epithelial cilium movement (GO:0003351)3.01792643
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01300587
65regulation of synaptic vesicle exocytosis (GO:2000300)3.00631627
66glutamate secretion (GO:0014047)3.00209662
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99970980
68purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.99596682
693-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.99596682
70axonal fasciculation (GO:0007413)2.98000108
71central nervous system projection neuron axonogenesis (GO:0021952)2.96050497
72negative regulation of neurotransmitter transport (GO:0051589)2.93897605
73positive regulation of synapse maturation (GO:0090129)2.93711367
74axoneme assembly (GO:0035082)2.93332008
75neurotransmitter-gated ion channel clustering (GO:0072578)2.93256078
76limb bud formation (GO:0060174)2.92493591
77protein complex biogenesis (GO:0070271)2.92490711
78reflex (GO:0060004)2.91940496
79negative regulation of neurotransmitter secretion (GO:0046929)2.91873124
80cellular response to ATP (GO:0071318)2.90864423
81dendrite morphogenesis (GO:0048813)2.90310778
82exploration behavior (GO:0035640)2.89649761
83nerve growth factor signaling pathway (GO:0038180)2.87194394
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87161620
85postsynaptic membrane organization (GO:0001941)2.86345029
86transmission of nerve impulse (GO:0019226)2.85868214
87gamma-aminobutyric acid signaling pathway (GO:0007214)2.84715228
88neuronal ion channel clustering (GO:0045161)2.84423747
89regulation of excitatory postsynaptic membrane potential (GO:0060079)2.82892497
90long-chain fatty acid biosynthetic process (GO:0042759)2.81558869
91spinal cord motor neuron differentiation (GO:0021522)2.80800473
92amine catabolic process (GO:0009310)2.80303512
93cellular biogenic amine catabolic process (GO:0042402)2.80303512
94somite development (GO:0061053)2.79641109
95neuron recognition (GO:0008038)2.79302407
96nonmotile primary cilium assembly (GO:0035058)2.78889160
97intraciliary transport (GO:0042073)2.78792504
98regulation of postsynaptic membrane potential (GO:0060078)2.78277907
99membrane hyperpolarization (GO:0060081)2.77388971
100regulation of collateral sprouting (GO:0048670)2.76696746
101pyrimidine nucleobase catabolic process (GO:0006208)2.76656956
102rRNA catabolic process (GO:0016075)2.75994945
103histone H3-K36 demethylation (GO:0070544)2.75519692
104serotonin metabolic process (GO:0042428)2.75332470
105cellular potassium ion homeostasis (GO:0030007)2.73353524
106negative regulation of translation, ncRNA-mediated (GO:0040033)2.72795247
107regulation of translation, ncRNA-mediated (GO:0045974)2.72795247
108negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72795247
109primary amino compound metabolic process (GO:1901160)2.71748871
110regulation of neuronal synaptic plasticity (GO:0048168)2.71269696
111photoreceptor cell development (GO:0042461)2.71058041
112neural tube formation (GO:0001841)2.70602380
113mitochondrial respiratory chain complex assembly (GO:0033108)2.68918624
114protein-cofactor linkage (GO:0018065)2.68724048
115photoreceptor cell maintenance (GO:0045494)2.68701831
116neuronal action potential propagation (GO:0019227)2.67943622
117G-protein coupled receptor internalization (GO:0002031)2.66656038
118long-term memory (GO:0007616)2.66572856
119long-term synaptic potentiation (GO:0060291)2.64855594
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.64400224
121cornea development in camera-type eye (GO:0061303)2.64340140
122positive regulation of cardiac muscle cell differentiation (GO:2000727)2.63777821
123regulation of long-term neuronal synaptic plasticity (GO:0048169)2.63754929
124positive regulation of cAMP-mediated signaling (GO:0043950)2.63526214
125cell differentiation in hindbrain (GO:0021533)2.63039063
126cilium organization (GO:0044782)2.62897312
127membrane depolarization during action potential (GO:0086010)2.62522646
128regulation of synaptic transmission, glutamatergic (GO:0051966)2.62232491
129neuron remodeling (GO:0016322)2.61997536
130otic vesicle formation (GO:0030916)2.60945981
131cilium movement (GO:0003341)2.60348672
132gamma-aminobutyric acid transport (GO:0015812)2.60246541
133regulation of hippo signaling (GO:0035330)2.59311685
134neuronal action potential (GO:0019228)2.59253986
135cilium morphogenesis (GO:0060271)2.59087447
136dopamine transport (GO:0015872)2.59040695
137righting reflex (GO:0060013)2.58741677
138regulation of action potential (GO:0098900)2.58483079
139protein neddylation (GO:0045116)2.58184329
140embryonic epithelial tube formation (GO:0001838)2.56948948
141regulation of cell communication by electrical coupling (GO:0010649)2.56362296
142positive regulation of potassium ion transmembrane transport (GO:1901381)2.56333003
143regulation of synaptic vesicle transport (GO:1902803)2.56117281
144neurotransmitter secretion (GO:0007269)2.55140762
145negative regulation of astrocyte differentiation (GO:0048712)2.54340859
146regulation of mesoderm development (GO:2000380)2.54206447
147eye photoreceptor cell development (GO:0042462)2.54022476
148regulation of dendritic spine morphogenesis (GO:0061001)2.52275865
149cochlea development (GO:0090102)2.51567032
150glycerophospholipid catabolic process (GO:0046475)2.50878267
151regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.50529830
152amino acid import (GO:0043090)2.50444262
153regulation of neurotransmitter secretion (GO:0046928)2.49767846
154kidney morphogenesis (GO:0060993)2.49258170
155cilium assembly (GO:0042384)2.48996510
156dendritic spine organization (GO:0097061)2.48784394
157positive regulation of potassium ion transport (GO:0043268)2.48261394
158negative regulation of telomere maintenance (GO:0032205)2.47473329
159protein localization to cilium (GO:0061512)2.47384186
160cell migration in hindbrain (GO:0021535)2.47154284
161fucose catabolic process (GO:0019317)2.46416662
162L-fucose metabolic process (GO:0042354)2.46416662
163L-fucose catabolic process (GO:0042355)2.46416662
164regulation of mesenchymal cell apoptotic process (GO:2001053)2.46175497
165regulation of voltage-gated calcium channel activity (GO:1901385)2.45053708
166regulation of meiosis I (GO:0060631)2.44491058
167regulation of synaptic plasticity (GO:0048167)2.43721408
168preassembly of GPI anchor in ER membrane (GO:0016254)2.42396147
169DNA deamination (GO:0045006)2.41836994
170negative regulation of protein localization to cell surface (GO:2000009)2.41573680
171nephron tubule morphogenesis (GO:0072078)2.41069437
172nephron epithelium morphogenesis (GO:0072088)2.41069437
173central nervous system neuron axonogenesis (GO:0021955)2.40652083
174epithelial tube formation (GO:0072175)2.40640510
175membrane depolarization (GO:0051899)2.40178433
176positive regulation of action potential (GO:0045760)2.40063061
177cilium or flagellum-dependent cell motility (GO:0001539)2.39695278
178protein K6-linked ubiquitination (GO:0085020)2.39454830
179auditory receptor cell stereocilium organization (GO:0060088)2.39412855
180positive regulation of membrane potential (GO:0045838)2.39071338
181glycine transport (GO:0015816)2.39010914
182benzene-containing compound metabolic process (GO:0042537)2.38222484
183pituitary gland development (GO:0021983)2.38135285
184negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36406601
185respiratory chain complex IV assembly (GO:0008535)2.35771066
186regulation of glucokinase activity (GO:0033131)2.35400348
187regulation of hexokinase activity (GO:1903299)2.35400348
188DNA double-strand break processing (GO:0000729)2.35398342
189negative chemotaxis (GO:0050919)2.34988643
190parturition (GO:0007567)2.34721288
191negative regulation of axon guidance (GO:1902668)2.33140894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.22174678
2EZH2_22144423_ChIP-Seq_EOC_Human3.87353660
3ZNF274_21170338_ChIP-Seq_K562_Hela3.29206657
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77944128
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67456335
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41319714
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.28113259
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27492030
9EWS_26573619_Chip-Seq_HEK293_Human2.25771232
10DROSHA_22980978_ChIP-Seq_HELA_Human2.23960143
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.19468125
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12034159
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.07015235
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06872088
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94669362
16SMAD4_21799915_ChIP-Seq_A2780_Human1.91619403
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91111825
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91111825
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.89953702
20IGF1R_20145208_ChIP-Seq_DFB_Human1.88550239
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86519889
22REST_21632747_ChIP-Seq_MESCs_Mouse1.85720752
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82709747
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.82185321
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80723036
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.80331662
27TAF15_26573619_Chip-Seq_HEK293_Human1.77022328
28AR_21572438_ChIP-Seq_LNCaP_Human1.74200699
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73774230
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72417786
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71815670
32P300_19829295_ChIP-Seq_ESCs_Human1.71789944
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.70937390
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.69434487
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68561658
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67767269
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67224842
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66430343
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64800007
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62373117
41CBP_20019798_ChIP-Seq_JUKART_Human1.62373117
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60673088
43TP53_16413492_ChIP-PET_HCT116_Human1.59130975
44STAT3_23295773_ChIP-Seq_U87_Human1.58434202
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.58013586
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.57158824
47ER_23166858_ChIP-Seq_MCF-7_Human1.53770859
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53257745
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53170606
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53164873
51BCAT_22108803_ChIP-Seq_LS180_Human1.48600048
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48128097
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.47642253
54IRF1_19129219_ChIP-ChIP_H3396_Human1.47048496
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46394702
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46138609
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46081183
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45879986
59TCF4_23295773_ChIP-Seq_U87_Human1.45624848
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45437317
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44792275
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43572996
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.42504240
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.41468989
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41139509
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39763439
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.38366546
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.38284722
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36836876
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36704647
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36236331
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34514336
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.33922804
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32963257
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32963257
76AHR_22903824_ChIP-Seq_MCF-7_Human1.32912132
77AR_25329375_ChIP-Seq_VCAP_Human1.32376742
78RNF2_27304074_Chip-Seq_NSC_Mouse1.32169187
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.31905016
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.31762533
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30091307
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.29976818
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28008171
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27646497
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25425688
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25136258
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.24560300
88SOX2_19829295_ChIP-Seq_ESCs_Human1.24168126
89NANOG_19829295_ChIP-Seq_ESCs_Human1.24168126
90MYC_18940864_ChIP-ChIP_HL60_Human1.22861267
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22272704
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22217571
93RUNX2_22187159_ChIP-Seq_PCA_Human1.21217559
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20915485
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20527453
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.20502779
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20026421
98AR_19668381_ChIP-Seq_PC3_Human1.19964921
99TCF4_22108803_ChIP-Seq_LS180_Human1.19722128
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19523468
101* TP53_22573176_ChIP-Seq_HFKS_Human1.19381208
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18617244
103REST_18959480_ChIP-ChIP_MESCs_Mouse1.17970027
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17792035
105KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16870153
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.16761928
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16667798
108VDR_22108803_ChIP-Seq_LS180_Human1.16640758
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15717075
110P53_22387025_ChIP-Seq_ESCs_Mouse1.14287292
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13746578
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12819350
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.12369576
114SALL1_21062744_ChIP-ChIP_HESCs_Human1.12248731
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.10382923
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10124757
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09676872
118FUS_26573619_Chip-Seq_HEK293_Human1.09599422
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08663344
120ELK1_19687146_ChIP-ChIP_HELA_Human1.08642464
121NFE2_27457419_Chip-Seq_LIVER_Mouse1.08542605
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08211348
123GATA1_26923725_Chip-Seq_HPCs_Mouse1.06665419
124WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05793070
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.05750295
126P300_18555785_Chip-Seq_ESCs_Mouse1.04676661
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04377227
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03246907
129TBL1_22424771_ChIP-Seq_293T_Human1.03088212
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02918154
131NOTCH1_21737748_ChIP-Seq_TLL_Human1.02520341
132AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01181808
133KDM2B_26808549_Chip-Seq_REH_Human1.00060795
134FOXA1_25329375_ChIP-Seq_VCAP_Human0.99873384
135FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99873384
136CDX2_22108803_ChIP-Seq_LS180_Human0.99128380
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99027962
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98813875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.31160810
2MP0004859_abnormal_synaptic_plasticity4.81127686
3MP0005423_abnormal_somatic_nervous4.07311020
4MP0000566_synostosis3.12107826
5MP0000569_abnormal_digit_pigmentation2.94369117
6MP0009046_muscle_twitch2.91276860
7MP0003635_abnormal_synaptic_transmissio2.87832456
8MP0001486_abnormal_startle_reflex2.87636245
9MP0004270_analgesia2.84400163
10MP0009780_abnormal_chondrocyte_physiolo2.57537636
11MP0002064_seizures2.48694740
12MP0003195_calcinosis2.47370088
13MP0009745_abnormal_behavioral_response2.46311541
14MP0002063_abnormal_learning/memory/cond2.42642404
15MP0000778_abnormal_nervous_system2.35334600
16MP0005646_abnormal_pituitary_gland2.35204284
17MP0002822_catalepsy2.27317641
18MP0002572_abnormal_emotion/affect_behav2.26037694
19MP0003646_muscle_fatigue2.13454969
20MP0002272_abnormal_nervous_system2.09539430
21MP0003136_yellow_coat_color2.04568405
22MP0005645_abnormal_hypothalamus_physiol2.03568918
23MP0002938_white_spotting1.97354105
24MP0001188_hyperpigmentation1.89282906
25MP0004133_heterotaxia1.86354579
26MP0003787_abnormal_imprinting1.85679593
27MP0002734_abnormal_mechanical_nocicepti1.82418113
28MP0005386_behavior/neurological_phenoty1.77813972
29MP0004924_abnormal_behavior1.77813972
30MP0005084_abnormal_gallbladder_morpholo1.76068151
31MP0001968_abnormal_touch/_nociception1.75728098
32MP0003950_abnormal_plasma_membrane1.75638971
33MP0008872_abnormal_physiological_respon1.73478479
34MP0001440_abnormal_grooming_behavior1.70981793
35MP0002160_abnormal_reproductive_system1.70758060
36MP0006276_abnormal_autonomic_nervous1.69756527
37MP0002067_abnormal_sensory_capabilities1.69275428
38MP0003937_abnormal_limbs/digits/tail_de1.68588846
39MP0000920_abnormal_myelination1.66252390
40MP0005171_absent_coat_pigmentation1.64969483
41MP0002735_abnormal_chemical_nociception1.63152512
42MP0002638_abnormal_pupillary_reflex1.58654596
43MP0002184_abnormal_innervation1.57783207
44MP0004142_abnormal_muscle_tone1.57332689
45MP0000372_irregular_coat_pigmentation1.56747119
46MP0005551_abnormal_eye_electrophysiolog1.52356995
47MP0002876_abnormal_thyroid_physiology1.51971472
48MP0002837_dystrophic_cardiac_calcinosis1.51944426
49MP0005409_darkened_coat_color1.51758456
50MP0004742_abnormal_vestibular_system1.50227978
51MP0006072_abnormal_retinal_apoptosis1.48291236
52MP0005187_abnormal_penis_morphology1.46867326
53MP0004885_abnormal_endolymph1.46784521
54MP0001529_abnormal_vocalization1.45963809
55MP0002557_abnormal_social/conspecific_i1.42994146
56MP0002882_abnormal_neuron_morphology1.41652619
57MP0008569_lethality_at_weaning1.40893599
58MP0003690_abnormal_glial_cell1.40475643
59MP0006292_abnormal_olfactory_placode1.39107635
60MP0002736_abnormal_nociception_after1.39000618
61MP0002653_abnormal_ependyma_morphology1.38367327
62MP0000955_abnormal_spinal_cord1.37296205
63MP0010386_abnormal_urinary_bladder1.34233265
64MP0001984_abnormal_olfaction1.31813134
65MP0003718_maternal_effect1.28458641
66MP0002138_abnormal_hepatobiliary_system1.26071309
67MP0004145_abnormal_muscle_electrophysio1.25430147
68MP0003119_abnormal_digestive_system1.24379560
69MP0005367_renal/urinary_system_phenotyp1.21479309
70MP0000516_abnormal_urinary_system1.21479309
71MP0004811_abnormal_neuron_physiology1.20900840
72MP0002066_abnormal_motor_capabilities/c1.19882857
73MP0002229_neurodegeneration1.18593886
74MP0001299_abnormal_eye_distance/1.18544969
75MP0009250_abnormal_appendicular_skeleto1.18442946
76MP0003633_abnormal_nervous_system1.17305782
77MP0001501_abnormal_sleep_pattern1.16155504
78MP0001502_abnormal_circadian_rhythm1.15733896
79MP0001293_anophthalmia1.15650425
80MP0003137_abnormal_impulse_conducting1.15449995
81MP0001970_abnormal_pain_threshold1.14193667
82MP0002751_abnormal_autonomic_nervous1.13534907
83MP0003631_nervous_system_phenotype1.11581987
84MP0002102_abnormal_ear_morphology1.11087858
85MP0008789_abnormal_olfactory_epithelium1.10946788
86MP0003011_delayed_dark_adaptation1.10819473
87MP0002282_abnormal_trachea_morphology1.09937939
88MP0009384_cardiac_valve_regurgitation1.09312723
89MP0003634_abnormal_glial_cell1.08542899
90MP0003632_abnormal_nervous_system1.08421980
91MP0002152_abnormal_brain_morphology1.07800080
92MP0008995_early_reproductive_senescence1.06983703
93MP0001485_abnormal_pinna_reflex1.06002371
94MP0005503_abnormal_tendon_morphology1.05956325
95MP0005389_reproductive_system_phenotype1.05691378
96MP0001177_atelectasis1.03938417
97MP0001963_abnormal_hearing_physiology1.00854553
98MP0000751_myopathy1.00612353
99MP0000427_abnormal_hair_cycle0.98921153
100MP0002928_abnormal_bile_duct0.97946477
101MP0005257_abnormal_intraocular_pressure0.97534583
102MP0008877_abnormal_DNA_methylation0.97169444
103MP0002752_abnormal_somatic_nervous0.95559981
104MP0009697_abnormal_copulation0.95403031
105MP0002233_abnormal_nose_morphology0.94051204
106MP0002163_abnormal_gland_morphology0.92199680
107MP0004858_abnormal_nervous_system0.91962964
108MP0004147_increased_porphyrin_level0.90643186
109MP0003122_maternal_imprinting0.90351180
110MP0002733_abnormal_thermal_nociception0.89911848
111MP0004134_abnormal_chest_morphology0.88831983
112MP0000631_abnormal_neuroendocrine_gland0.88503682
113MP0000537_abnormal_urethra_morphology0.87549217
114MP0000647_abnormal_sebaceous_gland0.87453302
115MP0002234_abnormal_pharynx_morphology0.86423589
116MP0004233_abnormal_muscle_weight0.85451565
117MP0002295_abnormal_pulmonary_circulatio0.84817906
118MP0003879_abnormal_hair_cell0.83610968
119MP0004085_abnormal_heartbeat0.83256194
120MP0003938_abnormal_ear_development0.82998041
121MP0003942_abnormal_urinary_system0.82659047
122MP0000015_abnormal_ear_pigmentation0.79829468
123MP0002249_abnormal_larynx_morphology0.75048815
124MP0000026_abnormal_inner_ear0.74421039
125MP0005623_abnormal_meninges_morphology0.73977553
126MP0005410_abnormal_fertilization0.72704867
127MP0003861_abnormal_nervous_system0.71914275
128MP0004215_abnormal_myocardial_fiber0.71011560
129MP0000049_abnormal_middle_ear0.70202114
130MP0003755_abnormal_palate_morphology0.69293894
131MP0003045_fibrosis0.69224725
132MP0005377_hearing/vestibular/ear_phenot0.67022773
133MP0003878_abnormal_ear_physiology0.67022773
134MP0003698_abnormal_male_reproductive0.65644458
135MP0005253_abnormal_eye_physiology0.65376229
136MP0005195_abnormal_posterior_eye0.65215192
137MP0003890_abnormal_embryonic-extraembry0.64164299
138MP0001905_abnormal_dopamine_level0.64060582
139MP0003121_genomic_imprinting0.60922826
140MP0003183_abnormal_peptide_metabolism0.59796051
141MP0002082_postnatal_lethality0.58542835
142MP0010770_preweaning_lethality0.58542835

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.73457399
2Pancreatic cysts (HP:0001737)4.35764770
3True hermaphroditism (HP:0010459)4.26763018
4Febrile seizures (HP:0002373)4.25686187
5Pancreatic fibrosis (HP:0100732)4.21157953
6Hyperventilation (HP:0002883)4.09146284
7Epileptic encephalopathy (HP:0200134)3.77012597
8Focal seizures (HP:0007359)3.56930222
9Nephronophthisis (HP:0000090)3.52429181
10Abnormality of midbrain morphology (HP:0002418)3.50864258
11Molar tooth sign on MRI (HP:0002419)3.50864258
12Progressive cerebellar ataxia (HP:0002073)3.29056845
13Chronic hepatic failure (HP:0100626)3.25294957
14Abnormality of the corticospinal tract (HP:0002492)3.25250994
15Pendular nystagmus (HP:0012043)3.19369774
16Abolished electroretinogram (ERG) (HP:0000550)3.12789906
17Broad-based gait (HP:0002136)3.11177322
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.09474626
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.09474626
20Alacrima (HP:0000522)3.01535642
21Medial flaring of the eyebrow (HP:0010747)2.98128737
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94316178
23Methylmalonic acidemia (HP:0002912)2.94016765
24Excessive salivation (HP:0003781)2.87230499
25Drooling (HP:0002307)2.87230499
26Absent speech (HP:0001344)2.86661194
27Abnormality of the renal medulla (HP:0100957)2.84848103
28Type II lissencephaly (HP:0007260)2.82898737
29Aplasia involving bones of the upper limbs (HP:0009823)2.81765487
30Aplasia of the phalanges of the hand (HP:0009802)2.81765487
31Aplasia involving bones of the extremities (HP:0009825)2.81765487
32Myokymia (HP:0002411)2.81294967
33Attenuation of retinal blood vessels (HP:0007843)2.78344124
34Decreased lacrimation (HP:0000633)2.75861217
35Genetic anticipation (HP:0003743)2.75826926
36Gaze-evoked nystagmus (HP:0000640)2.75183396
37Increased corneal curvature (HP:0100692)2.72573291
38Keratoconus (HP:0000563)2.72573291
39Atonic seizures (HP:0010819)2.71845832
40Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.66985761
41Abnormal rod and cone electroretinograms (HP:0008323)2.63993003
42Scanning speech (HP:0002168)2.62648988
43Thickened helices (HP:0000391)2.61191645
44Cystic liver disease (HP:0006706)2.59906312
45Septo-optic dysplasia (HP:0100842)2.56637433
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.54343437
47Fair hair (HP:0002286)2.52681886
48Coronal craniosynostosis (HP:0004440)2.48712004
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.48368055
50Sclerocornea (HP:0000647)2.47323898
51Abnormality of the renal cortex (HP:0011035)2.46509176
52Dysmetria (HP:0001310)2.42324029
53Widely spaced teeth (HP:0000687)2.41633300
54Gait imbalance (HP:0002141)2.38046746
55Cerebellar dysplasia (HP:0007033)2.37974536
56Urinary bladder sphincter dysfunction (HP:0002839)2.36779287
57Abnormality of salivation (HP:0100755)2.34113677
58Anencephaly (HP:0002323)2.33762070
59Genital tract atresia (HP:0001827)2.33666242
60Congenital primary aphakia (HP:0007707)2.32395727
61Methylmalonic aciduria (HP:0012120)2.31080830
62Impaired vibration sensation in the lower limbs (HP:0002166)2.30826120
63Vaginal atresia (HP:0000148)2.28016430
64Cupped ear (HP:0000378)2.25721764
65Dialeptic seizures (HP:0011146)2.25485526
66Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.24720686
67Short 1st metacarpal (HP:0010034)2.24720686
68Male pseudohermaphroditism (HP:0000037)2.24693030
69Aqueductal stenosis (HP:0002410)2.24256409
70Hypothermia (HP:0002045)2.24053870
71Action tremor (HP:0002345)2.23892183
72Spastic gait (HP:0002064)2.23196075
73Nephrogenic diabetes insipidus (HP:0009806)2.22112137
74Short tibia (HP:0005736)2.21941411
75Abnormality of incisor morphology (HP:0011063)2.21660133
76Recurrent corneal erosions (HP:0000495)2.21588658
77Bony spicule pigmentary retinopathy (HP:0007737)2.20628000
78Agitation (HP:0000713)2.20296385
79Progressive inability to walk (HP:0002505)2.19085954
80Abnormality of alanine metabolism (HP:0010916)2.19065220
81Hyperalaninemia (HP:0003348)2.19065220
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19065220
83Chorioretinal atrophy (HP:0000533)2.18331453
84Bell-shaped thorax (HP:0001591)2.18276811
85Supranuclear gaze palsy (HP:0000605)2.17163950
86Ankle clonus (HP:0011448)2.14450219
87Duplicated collecting system (HP:0000081)2.14398381
88Poor eye contact (HP:0000817)2.12358343
89Generalized hypopigmentation of hair (HP:0011358)2.12242587
90Hyperglycinemia (HP:0002154)2.11652793
91Postaxial foot polydactyly (HP:0001830)2.11588269
92Furrowed tongue (HP:0000221)2.10066898
93Congenital sensorineural hearing impairment (HP:0008527)2.09513681
94Bile duct proliferation (HP:0001408)2.09508518
95Abnormal biliary tract physiology (HP:0012439)2.09508518
96Congenital hepatic fibrosis (HP:0002612)2.09436732
97Abnormal social behavior (HP:0012433)2.08564621
98Impaired social interactions (HP:0000735)2.08564621
99Protruding tongue (HP:0010808)2.07730852
100Postaxial hand polydactyly (HP:0001162)2.07201892
101Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05022172
102Abnormal hair whorl (HP:0010721)2.04851287
103Neurofibrillary tangles (HP:0002185)2.04576134
104Generalized tonic-clonic seizures (HP:0002069)2.02849348
105Lissencephaly (HP:0001339)2.02658765
106Tubular atrophy (HP:0000092)2.02507955
107Aplasia cutis congenita (HP:0001057)2.02350732
108Decreased central vision (HP:0007663)2.01499961
109Short hallux (HP:0010109)2.00523815
110Aplasia/Hypoplasia of the hallux (HP:0008362)1.99325352
111Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98952841
112Dysdiadochokinesis (HP:0002075)1.98756038
113Fetal akinesia sequence (HP:0001989)1.98337072
114Heterotopia (HP:0002282)1.97398738
115Abnormality of the labia minora (HP:0012880)1.96204870
116Absence seizures (HP:0002121)1.95587090
117Abnormal drinking behavior (HP:0030082)1.95104099
118Polydipsia (HP:0001959)1.95104099
119Hemiparesis (HP:0001269)1.94514940
120Gastroesophageal reflux (HP:0002020)1.92647924
121Urinary urgency (HP:0000012)1.92157356
122Intestinal atresia (HP:0011100)1.91884101
123Abnormality of the 1st metacarpal (HP:0010009)1.91137298
124Small hand (HP:0200055)1.90815110
125Occipital encephalocele (HP:0002085)1.89560949
126Intention tremor (HP:0002080)1.89083289
127Absent/shortened dynein arms (HP:0200106)1.88972298
128Dynein arm defect of respiratory motile cilia (HP:0012255)1.88972298
129Congenital stationary night blindness (HP:0007642)1.88073083
130Duplication of thumb phalanx (HP:0009942)1.87950735
131Exotropia (HP:0000577)1.87756151
132Inability to walk (HP:0002540)1.87690566
133Confusion (HP:0001289)1.86160494
134Visual hallucinations (HP:0002367)1.86088674
135Concave nail (HP:0001598)1.85797210
136Blue irides (HP:0000635)1.85592261
137Truncal ataxia (HP:0002078)1.85439751
138Oligodactyly (hands) (HP:0001180)1.84451841
139Absent septum pellucidum (HP:0001331)1.84042201
140Short phalanx of the thumb (HP:0009660)1.83867766
141Limited hip movement (HP:0008800)1.83503056
142Hypoplasia of the fovea (HP:0007750)1.83346316
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.83346316
144Congenital, generalized hypertrichosis (HP:0004540)1.82487050
145Adactyly (HP:0009776)1.82013487
146Abnormality of the antihelix (HP:0009738)1.81729907
147Thyroid-stimulating hormone excess (HP:0002925)1.81703598
148Atrial fibrillation (HP:0005110)1.81194853
149Preaxial hand polydactyly (HP:0001177)1.79976645
150Renal cortical cysts (HP:0000803)1.79785060
151Epileptiform EEG discharges (HP:0011182)1.79704904
152Optic nerve hypoplasia (HP:0000609)1.79405128
153Onion bulb formation (HP:0003383)1.77496629
154Postural instability (HP:0002172)1.76312681
155Megalencephaly (HP:0001355)1.76183358
156Abnormality of the renal collecting system (HP:0004742)1.76125992
157Colon cancer (HP:0003003)1.75109140
158Abnormal respiratory motile cilium physiology (HP:0012261)1.74854273
159Severe visual impairment (HP:0001141)1.74439740
160Infantile muscular hypotonia (HP:0008947)1.73127146
161Aplasia/Hypoplasia of the uvula (HP:0010293)1.73071773
162Midline defect of the nose (HP:0004122)1.72631527
163Poor coordination (HP:0002370)1.72273146
164Abnormality of the right ventricle (HP:0001707)1.71747335
165Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.71558166
166Myelomeningocele (HP:0002475)1.70850947
167Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70614677
168Choroideremia (HP:0001139)1.70199996
169EEG with generalized epileptiform discharges (HP:0011198)1.69286314
170Clumsiness (HP:0002312)1.69188995
171Dandy-Walker malformation (HP:0001305)1.69181681
172Specific learning disability (HP:0001328)1.68918346
173Dyschromatopsia (HP:0007641)1.68440204
174Chromsome breakage (HP:0040012)1.67847673
175Abnormal large intestine physiology (HP:0012700)1.67771743
176Lower limb muscle weakness (HP:0007340)1.66342373
177Abnormality of the ileum (HP:0001549)1.65987048
178Spastic paraplegia (HP:0001258)1.64319617
179Impaired vibratory sensation (HP:0002495)1.63987434
180Bowel incontinence (HP:0002607)1.63765667
181Abnormal respiratory epithelium morphology (HP:0012253)1.63671662
182Abnormal respiratory motile cilium morphology (HP:0005938)1.63671662
183Primary atrial arrhythmia (HP:0001692)1.63444769
184Abnormal ciliary motility (HP:0012262)1.62890006
185Sensory axonal neuropathy (HP:0003390)1.62294015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.03203146
2EPHA43.49187399
3NTRK33.41003916
4MAP4K22.80715895
5CASK2.79392288
6PINK12.73096895
7WNK32.72279524
8MARK12.62029294
9TNIK2.55264740
10BRD42.53700714
11GRK12.51264345
12TAOK32.22181664
13INSRR2.21114355
14PRPF4B2.17780527
15MAP3K42.10382432
16MAP2K72.06235253
17NTRK21.75995571
18ACVR1B1.74698941
19TRIM281.73357845
20SGK21.69856126
21MAP3K91.63902714
22SGK4941.62949227
23SGK2231.62949227
24OXSR11.61208783
25SIK31.59097156
26PAK61.55570912
27WNK41.50502026
28AKT31.49874038
29FGFR21.49786638
30CAMK1G1.48647802
31SIK21.43887509
32SGK31.43635131
33PKN11.40474313
34PLK21.40184735
35DYRK21.39406726
36WNK11.36498183
37CDK121.36359120
38MAPK131.36318928
39BCR1.30209593
40BRSK21.28382456
41VRK11.19715128
42MUSK1.18120801
43PNCK1.16248720
44STK38L1.13782390
45CAMK1D1.13254029
46TLK11.12286804
47ADRBK11.11218181
48ICK1.10421177
49STK391.10258159
50CSNK1G11.09597986
51DYRK31.08657643
52NEK61.08398919
53STK161.08397170
54SGK11.06016516
55ERBB31.05790413
56PHKG21.05094842
57PHKG11.05094842
58OBSCN1.04520654
59FGFR31.02824732
60CSNK1G31.00968359
61CDK51.00793820
62MAP3K70.98032469
63RIPK40.92094810
64MAP2K40.91932829
65PBK0.91697467
66TIE10.91358137
67DAPK20.91300070
68TNK20.90693404
69UHMK10.89925867
70CDK80.88418276
71TAF10.87975885
72YES10.87915374
73MAP3K130.87114591
74CAMKK20.86401010
75MARK20.86277709
76MKNK10.84013017
77CDK190.83543900
78PLK30.83349099
79PRKCE0.83115379
80CAMK2A0.82888086
81TGFBR10.81916372
82ZAK0.79980683
83MAPK70.79675353
84PRKCG0.79436928
85STK380.77373805
86PRKD30.75913105
87PLK40.75877845
88MAPK100.75838814
89ADRBK20.75380900
90MINK10.72480291
91STK110.71977641
92CAMK10.71647667
93CAMK2B0.71321348
94BCKDK0.70381082
95CAMK40.69038534
96PAK30.68629084
97BMPR20.68533094
98CDC42BPA0.68246537
99CSNK1A1L0.67897855
100EIF2AK30.67456301
101CAMK2D0.65826262
102DYRK1A0.64074484
103CSNK1D0.62905969
104GRK70.62809284
105PRKCZ0.62105043
106CDK30.61955770
107PRKG10.61870541
108MST40.60776347
109PRKCH0.60510549
110RPS6KA30.60020864
111PRKD20.59569443
112ALK0.59240221
113STK30.57444676
114CSNK1G20.56536124
115ROCK20.55786125
116KSR10.54931043
117ERBB40.54809223
118FGFR10.54462140
119FER0.53583433
120FGR0.53248616
121MAPK80.52430073
122GSK3B0.52226138
123NUAK10.52178676
124CSNK1A10.51857147
125PTK2B0.51359035
126CAMK2G0.51338950
127TXK0.51249685
128BMPR1B0.50838899
129RPS6KA50.50274271
130DMPK0.49787042
131EPHA30.49340755
132PRKACB0.48965781
133PIK3CA0.46852402
134PLK10.46521161
135PRKAA20.45305411
136WEE10.45043150
137MAPKAPK50.44605613
138PRKACA0.44245368
139MKNK20.43881700
140EPHB10.43844212
141PRKCI0.43095526
142MAP3K20.42996648
143ERBB20.42118855
144TEC0.41995203
145MAPK150.40578490
146CHEK20.38683397
147MAP3K120.37782576
148VRK20.37123828
149GRK50.37122161
150NLK0.35335010
151PRKCQ0.35262274

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57733965
2Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53361693
3Glutamatergic synapse_Homo sapiens_hsa047242.48496498
4Circadian entrainment_Homo sapiens_hsa047132.41594751
5Selenocompound metabolism_Homo sapiens_hsa004502.33262970
6Morphine addiction_Homo sapiens_hsa050322.32700269
7GABAergic synapse_Homo sapiens_hsa047272.32697597
8Basal transcription factors_Homo sapiens_hsa030222.30740020
9Synaptic vesicle cycle_Homo sapiens_hsa047212.18958060
10Olfactory transduction_Homo sapiens_hsa047402.17654302
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.15823890
12Oxidative phosphorylation_Homo sapiens_hsa001902.10570815
13Butanoate metabolism_Homo sapiens_hsa006502.07359984
14Long-term potentiation_Homo sapiens_hsa047201.93237283
15Nitrogen metabolism_Homo sapiens_hsa009101.88198300
16Linoleic acid metabolism_Homo sapiens_hsa005911.83886264
17Protein export_Homo sapiens_hsa030601.82704864
18Homologous recombination_Homo sapiens_hsa034401.82593037
19Axon guidance_Homo sapiens_hsa043601.79144295
20Serotonergic synapse_Homo sapiens_hsa047261.78508261
21Tryptophan metabolism_Homo sapiens_hsa003801.77092160
22Salivary secretion_Homo sapiens_hsa049701.73308017
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72384584
24Amphetamine addiction_Homo sapiens_hsa050311.71974368
25Parkinsons disease_Homo sapiens_hsa050121.66926464
26RNA polymerase_Homo sapiens_hsa030201.66664851
27Calcium signaling pathway_Homo sapiens_hsa040201.65894372
28Taste transduction_Homo sapiens_hsa047421.62316394
29Insulin secretion_Homo sapiens_hsa049111.61108594
30Cholinergic synapse_Homo sapiens_hsa047251.59454920
31Dopaminergic synapse_Homo sapiens_hsa047281.55360510
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48996570
33Long-term depression_Homo sapiens_hsa047301.48757107
34Fanconi anemia pathway_Homo sapiens_hsa034601.48313389
35Phototransduction_Homo sapiens_hsa047441.47864971
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46905753
37Type II diabetes mellitus_Homo sapiens_hsa049301.46050100
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42992754
39Dorso-ventral axis formation_Homo sapiens_hsa043201.42427390
40Oxytocin signaling pathway_Homo sapiens_hsa049211.42332746
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42143848
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40030075
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39518872
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38911686
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37789452
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.36583028
47Huntingtons disease_Homo sapiens_hsa050161.36060306
48Renin secretion_Homo sapiens_hsa049241.35677791
49Gastric acid secretion_Homo sapiens_hsa049711.35037417
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33629047
51ErbB signaling pathway_Homo sapiens_hsa040121.33481942
52Chemical carcinogenesis_Homo sapiens_hsa052041.32236882
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31512332
54Caffeine metabolism_Homo sapiens_hsa002321.31182357
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29536703
56cAMP signaling pathway_Homo sapiens_hsa040241.26951917
57Propanoate metabolism_Homo sapiens_hsa006401.26717314
58RNA degradation_Homo sapiens_hsa030181.24835844
59Regulation of autophagy_Homo sapiens_hsa041401.19974382
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19158043
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14445785
62Sulfur metabolism_Homo sapiens_hsa009201.09476521
63Steroid hormone biosynthesis_Homo sapiens_hsa001401.09318632
64Dilated cardiomyopathy_Homo sapiens_hsa054141.08436312
65Alzheimers disease_Homo sapiens_hsa050101.05624577
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04248222
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02463031
68Cocaine addiction_Homo sapiens_hsa050301.00679306
69Retinol metabolism_Homo sapiens_hsa008300.98714260
70GnRH signaling pathway_Homo sapiens_hsa049120.96918171
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96306388
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95451654
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93935099
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92724847
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92592317
76Peroxisome_Homo sapiens_hsa041460.92531806
77Gap junction_Homo sapiens_hsa045400.90912293
78Ras signaling pathway_Homo sapiens_hsa040140.87945975
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87945465
80One carbon pool by folate_Homo sapiens_hsa006700.87856521
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.87237081
82Collecting duct acid secretion_Homo sapiens_hsa049660.86585572
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86459155
84MAPK signaling pathway_Homo sapiens_hsa040100.85902542
85Wnt signaling pathway_Homo sapiens_hsa043100.85082970
86Glioma_Homo sapiens_hsa052140.84864936
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82182689
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82096691
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81325491
90Choline metabolism in cancer_Homo sapiens_hsa052310.80365038
91Ovarian steroidogenesis_Homo sapiens_hsa049130.79694755
92Steroid biosynthesis_Homo sapiens_hsa001000.79052548
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78652131
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76568327
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76111491
96Melanogenesis_Homo sapiens_hsa049160.76081472
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.75515968
98Glycerolipid metabolism_Homo sapiens_hsa005610.74646599
99Renal cell carcinoma_Homo sapiens_hsa052110.74576227
100Hedgehog signaling pathway_Homo sapiens_hsa043400.74348486
101Inositol phosphate metabolism_Homo sapiens_hsa005620.73573206
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73217133
103beta-Alanine metabolism_Homo sapiens_hsa004100.72914781
104Ether lipid metabolism_Homo sapiens_hsa005650.71441820
105Fat digestion and absorption_Homo sapiens_hsa049750.70350383
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70128000
107ABC transporters_Homo sapiens_hsa020100.69172514
108Fatty acid elongation_Homo sapiens_hsa000620.69107904
109Circadian rhythm_Homo sapiens_hsa047100.66828299
110Rap1 signaling pathway_Homo sapiens_hsa040150.66232274
111Arachidonic acid metabolism_Homo sapiens_hsa005900.65183037
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64469932
113TGF-beta signaling pathway_Homo sapiens_hsa043500.63525163
114Vitamin digestion and absorption_Homo sapiens_hsa049770.63329662
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63205092
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62014673
117Alcoholism_Homo sapiens_hsa050340.61707627
118Hippo signaling pathway_Homo sapiens_hsa043900.61301102
119Estrogen signaling pathway_Homo sapiens_hsa049150.60244259
120Pancreatic secretion_Homo sapiens_hsa049720.59889633
121Notch signaling pathway_Homo sapiens_hsa043300.59423612
122Purine metabolism_Homo sapiens_hsa002300.59266772
123Mineral absorption_Homo sapiens_hsa049780.58076324
124Basal cell carcinoma_Homo sapiens_hsa052170.57818067
125Metabolic pathways_Homo sapiens_hsa011000.56836836
126African trypanosomiasis_Homo sapiens_hsa051430.54281830
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54079310
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51650724
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51352571
130Rheumatoid arthritis_Homo sapiens_hsa053230.49873836
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49856315
132Lysine degradation_Homo sapiens_hsa003100.49678884
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48222663
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.47371039
135Vitamin B6 metabolism_Homo sapiens_hsa007500.47240400
136Melanoma_Homo sapiens_hsa052180.46987346
137Systemic lupus erythematosus_Homo sapiens_hsa053220.45622340
138Autoimmune thyroid disease_Homo sapiens_hsa053200.44909030
139Cardiac muscle contraction_Homo sapiens_hsa042600.43785586
140RNA transport_Homo sapiens_hsa030130.42878196
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.42760591
142Pyrimidine metabolism_Homo sapiens_hsa002400.41705195
143Fatty acid biosynthesis_Homo sapiens_hsa000610.41695547
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39925151
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39911577
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39878806
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.38409001
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37814446
149Glutathione metabolism_Homo sapiens_hsa004800.37721058
150Endometrial cancer_Homo sapiens_hsa052130.36886362
151Endocytosis_Homo sapiens_hsa041440.36793082
152Tight junction_Homo sapiens_hsa045300.36549463
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36354525
154Chemokine signaling pathway_Homo sapiens_hsa040620.34756484
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34321463
156mTOR signaling pathway_Homo sapiens_hsa041500.34093619
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33723364
158FoxO signaling pathway_Homo sapiens_hsa040680.33130740
159Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31520432

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