SERBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.45821477
2nuclear pore organization (GO:0006999)5.00705732
3nuclear pore complex assembly (GO:0051292)4.93491961
4protein localization to kinetochore (GO:0034501)4.52320228
5maturation of SSU-rRNA (GO:0030490)4.42012964
6DNA replication initiation (GO:0006270)4.39040378
7DNA strand elongation involved in DNA replication (GO:0006271)4.24969498
8viral transcription (GO:0019083)4.22705746
9translational termination (GO:0006415)4.20799355
10DNA topological change (GO:0006265)4.20661754
11mitotic nuclear envelope disassembly (GO:0007077)4.16430916
12folic acid-containing compound biosynthetic process (GO:0009396)4.14628273
13protein complex localization (GO:0031503)4.12864791
14ribosomal small subunit assembly (GO:0000028)4.10195781
15DNA replication-dependent nucleosome organization (GO:0034723)4.07602681
16DNA replication-dependent nucleosome assembly (GO:0006335)4.07602681
17formation of translation preinitiation complex (GO:0001731)4.04927901
18DNA strand elongation (GO:0022616)4.02378616
19IMP biosynthetic process (GO:0006188)4.00115499
20mitotic sister chromatid cohesion (GO:0007064)3.98078503
21mitotic metaphase plate congression (GO:0007080)3.95251059
22protein localization to chromosome, centromeric region (GO:0071459)3.90296939
23membrane disassembly (GO:0030397)3.90214039
24nuclear envelope disassembly (GO:0051081)3.90214039
25cellular protein complex localization (GO:0034629)3.84403871
26DNA duplex unwinding (GO:0032508)3.81416531
27translational initiation (GO:0006413)3.80711396
28DNA geometric change (GO:0032392)3.80175990
29ribosomal large subunit biogenesis (GO:0042273)3.79895066
30translational elongation (GO:0006414)3.78061234
31ribosome assembly (GO:0042255)3.77180988
32nucleobase biosynthetic process (GO:0046112)3.75829998
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.75027456
34pore complex assembly (GO:0046931)3.71956146
35kinetochore organization (GO:0051383)3.70336908
36telomere maintenance via semi-conservative replication (GO:0032201)3.70164947
37regulation of histone H3-K9 methylation (GO:0051570)3.70096626
38IMP metabolic process (GO:0046040)3.63948621
39ribosomal small subunit biogenesis (GO:0042274)3.63654383
40chromatin remodeling at centromere (GO:0031055)3.59025159
41metaphase plate congression (GO:0051310)3.58998983
42mitotic chromosome condensation (GO:0007076)3.55997117
43DNA replication checkpoint (GO:0000076)3.55518983
44double-strand break repair via nonhomologous end joining (GO:0006303)3.55180583
45non-recombinational repair (GO:0000726)3.55180583
46negative regulation of mRNA metabolic process (GO:1903312)3.55057635
47sister chromatid segregation (GO:0000819)3.53080343
48regulation of gene silencing by RNA (GO:0060966)3.49617435
49regulation of posttranscriptional gene silencing (GO:0060147)3.49617435
50regulation of gene silencing by miRNA (GO:0060964)3.49617435
51regulation of centriole replication (GO:0046599)3.49582518
52negative regulation of histone methylation (GO:0031061)3.48923355
53CENP-A containing nucleosome assembly (GO:0034080)3.47781023
54mitotic sister chromatid segregation (GO:0000070)3.45569857
55regulation of spindle organization (GO:0090224)3.45313427
56establishment of viral latency (GO:0019043)3.44021279
57mitotic recombination (GO:0006312)3.43126905
58ribonucleoprotein complex biogenesis (GO:0022613)3.42155954
59DNA replication-independent nucleosome assembly (GO:0006336)3.41528815
60DNA replication-independent nucleosome organization (GO:0034724)3.41528815
61pre-miRNA processing (GO:0031054)3.41148906
62regulation of helicase activity (GO:0051095)3.37572382
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.37096043
64heterochromatin organization (GO:0070828)3.36095124
65telomere maintenance via recombination (GO:0000722)3.35166783
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.33875837
67cellular protein complex disassembly (GO:0043624)3.33738768
68purine nucleobase biosynthetic process (GO:0009113)3.33702887
69negative regulation of RNA splicing (GO:0033119)3.30986712
70mRNA stabilization (GO:0048255)3.30576676
71RNA stabilization (GO:0043489)3.30576676
72regulation of translational fidelity (GO:0006450)3.29496042
73ATP-dependent chromatin remodeling (GO:0043044)3.26986103
74SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26302269
75ribosome biogenesis (GO:0042254)3.25658193
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22091775
77chromatin assembly or disassembly (GO:0006333)3.22057221
78viral life cycle (GO:0019058)3.21959301
79positive regulation of chromosome segregation (GO:0051984)3.20522786
80telomere maintenance via telomere lengthening (GO:0010833)3.17954591
81protein targeting to ER (GO:0045047)3.17688451
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.16916082
83protein complex disassembly (GO:0043241)3.16420958
84cotranslational protein targeting to membrane (GO:0006613)3.16369269
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15691427
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.15691427
87chromosome condensation (GO:0030261)3.14061049
88histone exchange (GO:0043486)3.11709718
89establishment of chromosome localization (GO:0051303)3.10951950
90rRNA processing (GO:0006364)3.10043893
91regulation of chromosome segregation (GO:0051983)3.09234487
92attachment of spindle microtubules to kinetochore (GO:0008608)3.08919109
93regulation of centrosome cycle (GO:0046605)3.08148043
94regulation of mitotic spindle organization (GO:0060236)3.07959848
95regulation of RNA export from nucleus (GO:0046831)3.07625734
96establishment of integrated proviral latency (GO:0075713)3.07402833
97dosage compensation (GO:0007549)3.07318808
98spliceosomal tri-snRNP complex assembly (GO:0000244)3.06095358
99regulation of translational termination (GO:0006449)3.05960648
100DNA conformation change (GO:0071103)3.05606140
101RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.05370398
102mRNA splicing, via spliceosome (GO:0000398)3.05370398
103RNA splicing, via transesterification reactions (GO:0000375)3.05325095
104L-serine metabolic process (GO:0006563)3.05310682
105nucleotide-excision repair, DNA gap filling (GO:0006297)3.04513694
106kinetochore assembly (GO:0051382)3.04317598
107establishment of protein localization to endoplasmic reticulum (GO:0072599)3.04113993
108chromatin assembly (GO:0031497)3.03552459
109nuclear-transcribed mRNA catabolic process (GO:0000956)3.02748203
110nuclear envelope organization (GO:0006998)3.02233264
111negative regulation of mRNA processing (GO:0050686)3.02150893
112negative regulation of chromosome segregation (GO:0051985)3.02009098
113rRNA metabolic process (GO:0016072)3.01769172
114DNA ligation (GO:0006266)3.01154565
115regulation of sister chromatid cohesion (GO:0007063)2.98518048
116translesion synthesis (GO:0019985)2.98029757
117macromolecular complex disassembly (GO:0032984)2.97175535
118regulation of nucleobase-containing compound transport (GO:0032239)2.96533543
119mRNA transport (GO:0051028)2.93477114
120protein-DNA complex disassembly (GO:0032986)2.93031351
121nucleosome disassembly (GO:0006337)2.93031351
122termination of RNA polymerase II transcription (GO:0006369)2.92944904
123peptidyl-arginine omega-N-methylation (GO:0035247)2.90976381
124negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90224303
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.90224303
126negative regulation of sister chromatid segregation (GO:0033046)2.90224303
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90224303
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90224303
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87584485
130regulation of mitotic metaphase/anaphase transition (GO:0030071)2.87584485
131spindle checkpoint (GO:0031577)2.84576087
132DNA synthesis involved in DNA repair (GO:0000731)2.83972182
133paraxial mesoderm development (GO:0048339)2.82737982

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.79194252
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.48538726
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10849063
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.50744208
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26986179
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.25923551
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.87813529
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84809100
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51642192
10NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39328893
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34206649
12AR_21909140_ChIP-Seq_LNCAP_Human2.33632444
13XRN2_22483619_ChIP-Seq_HELA_Human2.33430109
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.29089780
15* E2F1_21310950_ChIP-Seq_MCF-7_Human2.25564878
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.20735433
17* MYC_22102868_ChIP-Seq_BL_Human2.07027798
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06305206
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06098020
20E2F7_22180533_ChIP-Seq_HELA_Human10.0162309
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99756367
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98603029
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98067836
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96008742
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94327966
26* VDR_23849224_ChIP-Seq_CD4+_Human1.90204441
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90119053
28* GABP_17652178_ChIP-ChIP_JURKAT_Human1.89935163
29* TTF2_22483619_ChIP-Seq_HELA_Human1.79681202
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79222876
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77733653
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75612814
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75036788
34FOXP3_21729870_ChIP-Seq_TREG_Human1.72182061
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69753211
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69539979
37CIITA_25753668_ChIP-Seq_RAJI_Human1.65298461
38* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60753609
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60307331
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60098576
41DCP1A_22483619_ChIP-Seq_HELA_Human1.59252680
42ELK1_19687146_ChIP-ChIP_HELA_Human1.56754281
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.53594284
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52080585
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51281211
46* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50792559
47* GABP_19822575_ChIP-Seq_HepG2_Human1.47969667
48KDM5A_27292631_Chip-Seq_BREAST_Human1.46095229
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.45080234
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39774187
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37396081
52* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37097683
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36531385
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36257800
55* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36224850
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31197246
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31103194
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26490783
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25271445
60CLOCK_20551151_ChIP-Seq_293T_Human1.24317641
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24033902
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23195770
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20561956
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20114761
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20101964
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19389816
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17187454
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17187454
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17187454
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17016893
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15297539
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14503356
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14144475
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13338661
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13000772
76* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11395059
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09571600
78VDR_21846776_ChIP-Seq_THP-1_Human1.09520713
79TFEB_21752829_ChIP-Seq_HELA_Human1.08717310
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08663592
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07204005
82* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06940620
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06141122
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05924306
85* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05866807
86* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05808661
87SOX17_20123909_ChIP-Seq_XEN_Mouse1.05092269
88* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02745417
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.01627677
90ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01097335
91NANOG_21062744_ChIP-ChIP_HESCs_Human0.99223033
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98515031
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96972768
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95818548
95* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95515091
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94177185
97ZNF263_19887448_ChIP-Seq_K562_Human0.93732431
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93024781
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92833864
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.92629963
101TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92175339
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91942999
103* MYC_18940864_ChIP-ChIP_HL60_Human0.91506496
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90137176
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89541104
106TP63_17297297_ChIP-ChIP_HaCaT_Human0.89391840
107* CHD1_26751641_Chip-Seq_LNCaP_Human0.88917970
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.88566169
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88395106
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87653509
111SOX2_16153702_ChIP-ChIP_HESCs_Human0.87503521
112* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86745338
113* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86343000
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84531690
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83717880
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82136753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.66138103
2MP0010094_abnormal_chromosome_stability4.34439869
3MP0004957_abnormal_blastocyst_morpholog4.15378957
4MP0003111_abnormal_nucleus_morphology4.10029970
5MP0003077_abnormal_cell_cycle3.65616327
6MP0008057_abnormal_DNA_replication3.49398478
7MP0010352_gastrointestinal_tract_polyps3.02766789
8MP0008058_abnormal_DNA_repair2.65499379
9MP0003123_paternal_imprinting2.55285730
10MP0008007_abnormal_cellular_replicative2.51307549
11MP0001730_embryonic_growth_arrest2.50260750
12MP0008932_abnormal_embryonic_tissue2.39711141
13MP0000350_abnormal_cell_proliferation2.37323006
14MP0002396_abnormal_hematopoietic_system2.25274646
15MP0010307_abnormal_tumor_latency2.21240741
16MP0001672_abnormal_embryogenesis/_devel1.95722618
17MP0005380_embryogenesis_phenotype1.95722618
18MP0005076_abnormal_cell_differentiation1.92836287
19MP0004197_abnormal_fetal_growth/weight/1.92536383
20MP0001697_abnormal_embryo_size1.92037748
21MP0002084_abnormal_developmental_patter1.90028530
22MP0002009_preneoplasia1.84879229
23MP0000537_abnormal_urethra_morphology1.82109522
24MP0002085_abnormal_embryonic_tissue1.81056482
25MP0003984_embryonic_growth_retardation1.79770959
26MP0002088_abnormal_embryonic_growth/wei1.78101572
27MP0003567_abnormal_fetal_cardiomyocyte1.75371632
28MP0009697_abnormal_copulation1.74815941
29MP0003705_abnormal_hypodermis_morpholog1.70448155
30MP0002080_prenatal_lethality1.69845010
31MP0008877_abnormal_DNA_methylation1.69610202
32MP0002086_abnormal_extraembryonic_tissu1.69085250
33MP0003121_genomic_imprinting1.58629041
34MP0010030_abnormal_orbit_morphology1.57893362
35MP0000490_abnormal_crypts_of1.55496232
36MP0004808_abnormal_hematopoietic_stem1.55175401
37MP0009053_abnormal_anal_canal1.54720155
38MP0003890_abnormal_embryonic-extraembry1.53601889
39MP0001293_anophthalmia1.53403803
40MP0003786_premature_aging1.40966531
41MP0003941_abnormal_skin_development1.34105262
42MP0000313_abnormal_cell_death1.32810134
43MP0002796_impaired_skin_barrier1.31327184
44MP0010234_abnormal_vibrissa_follicle1.25650194
45MP0002019_abnormal_tumor_incidence1.24623761
46MP0001661_extended_life_span1.24371867
47MP0003119_abnormal_digestive_system1.23487494
48MP0009672_abnormal_birth_weight1.22002606
49MP0005623_abnormal_meninges_morphology1.20090175
50MP0000703_abnormal_thymus_morphology1.10093928
51MP0003566_abnormal_cell_adhesion1.09938597
52MP0003937_abnormal_limbs/digits/tail_de1.09497646
53MP0001188_hyperpigmentation1.09316487
54MP0009703_decreased_birth_body1.07919855
55MP0003315_abnormal_perineum_morphology1.04738620
56MP0000428_abnormal_craniofacial_morphol1.03369409
57MP0006054_spinal_hemorrhage0.99865989
58MP0002111_abnormal_tail_morphology0.99354233
59MP0000579_abnormal_nail_morphology0.98341606
60MP0001346_abnormal_lacrimal_gland0.96281280
61MP0002092_abnormal_eye_morphology0.95603893
62MP0001849_ear_inflammation0.94896413
63MP0000733_abnormal_muscle_development0.94885627
64MP0003385_abnormal_body_wall0.93472802
65MP0002697_abnormal_eye_size0.92819965
66MP0009379_abnormal_foot_pigmentation0.91875943
67MP0001286_abnormal_eye_development0.90139145
68MP0001545_abnormal_hematopoietic_system0.89787412
69MP0005397_hematopoietic_system_phenotyp0.89787412
70MP0003763_abnormal_thymus_physiology0.89274774
71MP0006292_abnormal_olfactory_placode0.88209381
72MP0005023_abnormal_wound_healing0.86799941
73MP0002210_abnormal_sex_determination0.85060491
74MP0001915_intracranial_hemorrhage0.84834667
75MP0010630_abnormal_cardiac_muscle0.84530940
76MP0004264_abnormal_extraembryonic_tissu0.82767530
77MP0000432_abnormal_head_morphology0.82333807
78MP0004272_abnormal_basement_membrane0.81925060
79MP0000762_abnormal_tongue_morphology0.81557448
80MP0005501_abnormal_skin_physiology0.80449430
81MP0001145_abnormal_male_reproductive0.79914908
82MP0003935_abnormal_craniofacial_develop0.79538484
83MP0004133_heterotaxia0.78714826
84MP0002233_abnormal_nose_morphology0.77784745
85MP0002722_abnormal_immune_system0.76776574
86MP0003942_abnormal_urinary_system0.76626234
87MP0000566_synostosis0.76564633
88MP0006035_abnormal_mitochondrial_morpho0.76517232
89MP0002925_abnormal_cardiovascular_devel0.76209818
90MP0002398_abnormal_bone_marrow0.75516195
91MP0002653_abnormal_ependyma_morphology0.75322264
92MP0008770_decreased_survivor_rate0.73908584
93MP0005384_cellular_phenotype0.73098177
94MP0001299_abnormal_eye_distance/0.72872395
95MP0000477_abnormal_intestine_morphology0.72115409
96MP0001727_abnormal_embryo_implantation0.71966794
97MP0003115_abnormal_respiratory_system0.71886471
98MP0005621_abnormal_cell_physiology0.70344800
99MP0003718_maternal_effect0.70299277
100MP0009333_abnormal_splenocyte_physiolog0.70157721
101MP0003861_abnormal_nervous_system0.69669346
102MP0000858_altered_metastatic_potential0.68631965
103MP0002081_perinatal_lethality0.68100673
104MP0003221_abnormal_cardiomyocyte_apopto0.67623517
105MP0002060_abnormal_skin_morphology0.66989654
106MP0004233_abnormal_muscle_weight0.66635514
107MP0000358_abnormal_cell_content/0.66433639
108MP0000377_abnormal_hair_follicle0.65890388
109MP0002877_abnormal_melanocyte_morpholog0.64758405
110MP0004087_abnormal_muscle_fiber0.63921466
111MP0000653_abnormal_sex_gland0.63526936
112MP0000678_abnormal_parathyroid_gland0.62467915
113MP0000383_abnormal_hair_follicle0.62237789
114MP0003943_abnormal_hepatobiliary_system0.62174969
115MP0003755_abnormal_palate_morphology0.61993836
116MP0002938_white_spotting0.61863906
117MP0004185_abnormal_adipocyte_glucose0.61554047
118MP0000689_abnormal_spleen_morphology0.61513447
119MP0000049_abnormal_middle_ear0.61505511
120MP0000266_abnormal_heart_morphology0.61332627
121MP0002269_muscular_atrophy0.61176486
122MP0005451_abnormal_body_composition0.61114182
123MP0001340_abnormal_eyelid_morphology0.61108892
124MP0010678_abnormal_skin_adnexa0.61079172
125MP0000516_abnormal_urinary_system0.60996778
126MP0005367_renal/urinary_system_phenotyp0.60996778
127MP0002114_abnormal_axial_skeleton0.60703871
128MP0009278_abnormal_bone_marrow0.58657239
129MP0002166_altered_tumor_susceptibility0.57457534
130MP0002932_abnormal_joint_morphology0.57446159

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.16642944
2Ependymoma (HP:0002888)4.11623793
3Colon cancer (HP:0003003)4.05945678
4Medulloblastoma (HP:0002885)3.77648026
5Birth length less than 3rd percentile (HP:0003561)3.65291512
6Abnormality of cells of the erythroid lineage (HP:0012130)3.50576345
7Selective tooth agenesis (HP:0001592)3.39432331
8Multiple enchondromatosis (HP:0005701)3.21088286
9Chromsome breakage (HP:0040012)3.15528298
10Abnormal number of erythroid precursors (HP:0012131)3.11218519
11Rhabdomyosarcoma (HP:0002859)3.05678912
12Volvulus (HP:0002580)3.00355724
13Proximal placement of thumb (HP:0009623)2.98880617
14Progressive muscle weakness (HP:0003323)2.95658382
15Agnosia (HP:0010524)2.94064671
16Astrocytoma (HP:0009592)2.93030092
17Abnormality of the astrocytes (HP:0100707)2.93030092
18Cortical dysplasia (HP:0002539)2.92555574
19Breast hypoplasia (HP:0003187)2.91884179
20Deviation of the thumb (HP:0009603)2.88779468
21Basal cell carcinoma (HP:0002671)2.82387407
22Oral leukoplakia (HP:0002745)2.81520284
23Nephroblastoma (Wilms tumor) (HP:0002667)2.81248696
24Biliary tract neoplasm (HP:0100574)2.80811296
25Increased nuchal translucency (HP:0010880)2.80555398
26Abnormal number of incisors (HP:0011064)2.77883869
27Abnormality of chromosome stability (HP:0003220)2.74299291
28Abnormality of the labia minora (HP:0012880)2.71886130
29Patellar aplasia (HP:0006443)2.69546034
30Neoplasm of the oral cavity (HP:0100649)2.69519336
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.68280585
32Embryonal renal neoplasm (HP:0011794)2.63794211
33Progressive external ophthalmoplegia (HP:0000590)2.61221227
34Glioma (HP:0009733)2.59934109
35Microvesicular hepatic steatosis (HP:0001414)2.56993003
36Aplasia/Hypoplasia of the patella (HP:0006498)2.56080687
37Calcaneovalgus deformity (HP:0001848)2.53627184
38Macrocytic anemia (HP:0001972)2.52955957
39Neoplasm of the pancreas (HP:0002894)2.49691612
40Pallor (HP:0000980)2.48975417
41Atresia of the external auditory canal (HP:0000413)2.47923796
42Absent thumb (HP:0009777)2.47611488
43Neoplasm of striated muscle (HP:0009728)2.45086057
44Abnormality of the preputium (HP:0100587)2.42265037
45Spastic diplegia (HP:0001264)2.40819560
46Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37241999
47Short 4th metacarpal (HP:0010044)2.37241999
48Meckel diverticulum (HP:0002245)2.36651776
49Abnormality of the anterior horn cell (HP:0006802)2.35883023
50Degeneration of anterior horn cells (HP:0002398)2.35883023
51Absent radius (HP:0003974)2.33911078
52Abnormality of the calcaneus (HP:0008364)2.29023695
53Myelodysplasia (HP:0002863)2.27432142
54Overlapping toe (HP:0001845)2.25555177
55Abnormality of the ileum (HP:0001549)2.21722755
56Prominent nose (HP:0000448)2.21381847
57Amaurosis fugax (HP:0100576)2.19196496
58Hyperacusis (HP:0010780)2.18323146
59Aplasia involving forearm bones (HP:0009822)2.16433366
60Absent forearm bone (HP:0003953)2.16433366
61Deep philtrum (HP:0002002)2.15001650
62Impulsivity (HP:0100710)2.13485120
63Missing ribs (HP:0000921)2.13260855
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.12894661
65Deformed tarsal bones (HP:0008119)2.12554825
66Overriding aorta (HP:0002623)2.10532712
67Squamous cell carcinoma (HP:0002860)2.09502260
68Aplasia/Hypoplasia of the sternum (HP:0006714)2.09169946
69Malignant gastrointestinal tract tumors (HP:0006749)2.08851675
70Gastrointestinal carcinoma (HP:0002672)2.08851675
71Pelvic girdle muscle weakness (HP:0003749)2.08585069
72Ectopic kidney (HP:0000086)2.08273278
73Duodenal stenosis (HP:0100867)2.07778263
74Small intestinal stenosis (HP:0012848)2.07778263
75Abnormality of abdominal situs (HP:0011620)2.05405211
76Abdominal situs inversus (HP:0003363)2.05405211
77Carpal bone hypoplasia (HP:0001498)2.04908735
78Neoplasm of the colon (HP:0100273)2.03990178
79Trismus (HP:0000211)2.03847700
80Insomnia (HP:0100785)2.02224733
81Asymmetry of the thorax (HP:0001555)2.01982227
82Aplastic anemia (HP:0001915)1.99854288
83Sparse lateral eyebrow (HP:0005338)1.99149332
84Adenoma sebaceum (HP:0009720)1.98439247
85Angiofibromas (HP:0010615)1.98439247
86Facial hemangioma (HP:0000329)1.98241974
87Esophageal atresia (HP:0002032)1.98237962
8811 pairs of ribs (HP:0000878)1.96953564
89Cafe-au-lait spot (HP:0000957)1.96790345
90Premature graying of hair (HP:0002216)1.96094297
91High pitched voice (HP:0001620)1.96064118
92Supernumerary bones of the axial skeleton (HP:0009144)1.95963381
93Dysmetric saccades (HP:0000641)1.95532376
94Facial cleft (HP:0002006)1.94399547
95Long eyelashes (HP:0000527)1.94335613
96Horseshoe kidney (HP:0000085)1.93470023
97Acute myeloid leukemia (HP:0004808)1.93372536
98Supernumerary spleens (HP:0009799)1.92891243
99Supernumerary ribs (HP:0005815)1.92530299
100Neoplasm of the rectum (HP:0100743)1.92427755
101Rough bone trabeculation (HP:0100670)1.90198284
102Ovarian neoplasm (HP:0100615)1.90147026
103Termporal pattern (HP:0011008)1.90037967
104Insidious onset (HP:0003587)1.90037967
105Tracheoesophageal fistula (HP:0002575)1.88790663
106Aplasia/hypoplasia of the humerus (HP:0006507)1.85998868
107Urethral obstruction (HP:0000796)1.85552319
108Short middle phalanx of the 5th finger (HP:0004220)1.85467524
109Sloping forehead (HP:0000340)1.84422825
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83769947
111Neoplasm of the small intestine (HP:0100833)1.83551326
112Duplication of thumb phalanx (HP:0009942)1.83422670
113Abnormal lung lobation (HP:0002101)1.83366228
114Choanal atresia (HP:0000453)1.81693052
115High anterior hairline (HP:0009890)1.81504394
116Increased density of long bones (HP:0006392)1.81358059
117Ankyloglossia (HP:0010296)1.80139870
118Abnormality of the duodenum (HP:0002246)1.80071962
119Abnormality of the umbilical cord (HP:0010881)1.79922191
120Abnormality of cochlea (HP:0000375)1.79780674
121Abnormality of glycolysis (HP:0004366)1.79052005
122Skin tags (HP:0010609)1.78664671
123Abnormality of the carotid arteries (HP:0005344)1.78618641
124Shoulder girdle muscle weakness (HP:0003547)1.78541301
125Cutis marmorata (HP:0000965)1.78512983
126Short thumb (HP:0009778)1.77372025
127Cellular immunodeficiency (HP:0005374)1.75870137
128Blepharitis (HP:0000498)1.75401177
129Skull defect (HP:0001362)1.74866104
130Abnormality of the salivary glands (HP:0010286)1.74701640
131Intestinal polyp (HP:0005266)1.74571634
132Triphalangeal thumb (HP:0001199)1.74406092
133Embryonal neoplasm (HP:0002898)1.72536526
134Pseudobulbar signs (HP:0002200)1.71883811
135Homocystinuria (HP:0002156)1.70751851
136Abnormality of homocysteine metabolism (HP:0010919)1.70751851
137Renal duplication (HP:0000075)1.63687859
138Abnormal umbilical cord blood vessels (HP:0011403)1.63498759
139Single umbilical artery (HP:0001195)1.63498759
140Abnormality of the fetal cardiovascular system (HP:0010948)1.63498759
141Glossoptosis (HP:0000162)1.59651918
142Septate vagina (HP:0001153)1.59516693
143Back pain (HP:0003418)1.57904237
144Increased serum pyruvate (HP:0003542)1.56758078
145Radioulnar synostosis (HP:0002974)1.56056506
146Breech presentation (HP:0001623)1.55227978
147Ulnar bowing (HP:0003031)1.54987064
148Uterine leiomyosarcoma (HP:0002891)1.53715052
149Leiomyosarcoma (HP:0100243)1.53715052
150Elfin facies (HP:0004428)1.53532143
151Obsessive-compulsive behavior (HP:0000722)1.53333944
152Abnormal cartilage morphology (HP:0002763)1.53038038
153Hepatoblastoma (HP:0002884)1.52788231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.95691384
2WEE13.77598618
3BUB13.19560938
4NEK22.86574119
5CDK122.75714214
6SRPK12.73782691
7SMG12.53586679
8EEF2K2.48174094
9TSSK62.44600813
10TTK2.32720086
11EIF2AK12.32253050
12PBK2.31338754
13MKNK12.25831527
14NEK12.18306574
15RPS6KB22.16634412
16TLK12.16341925
17PKN21.95523113
18SCYL21.90210047
19TAF11.87556176
20PASK1.83944579
21MAP3K101.80216592
22PLK11.78457353
23ACVR1B1.76788016
24RPS6KA41.76278922
25ATR1.75398649
26AURKB1.74320078
27EPHA21.70382921
28MKNK21.69487695
29CDK71.68790482
30PNCK1.63150945
31PLK31.61352782
32CDK41.57343444
33DYRK31.56175337
34TGFBR11.55277900
35MAP3K81.51518764
36BRSK21.48407566
37CHEK11.42954735
38STK101.42685702
39ICK1.41946706
40CHEK21.41468986
41BRD41.40863843
42NME21.38768055
43VRK21.38465230
44ALK1.26377269
45TESK21.25902064
46PLK41.20860314
47PDK21.18003734
48CDK61.17740168
49EIF2AK31.16431099
50VRK11.14093517
51ATM1.12885150
52PAK41.12132813
53AURKA1.10040889
54FLT31.07542269
55STK41.06190032
56CDK21.02527766
57LRRK20.97798822
58LATS10.88580261
59ZAK0.86749595
60PIM10.81821019
61CSNK2A20.80486407
62MTOR0.80319559
63STK240.79657567
64CAMK1G0.73803819
65CDK10.72728279
66STK30.72291488
67FGFR10.70645117
68BRAF0.69851438
69MELK0.67898490
70CLK10.67747719
71BRSK10.67063323
72CSNK1E0.66358327
73MAP3K90.65317303
74TTN0.64914311
75CAMK1D0.64857280
76PAK20.63681263
77ERBB40.57623658
78LATS20.57393732
79TNIK0.57223782
80AKT20.56769697
81DMPK0.56405602
82STK38L0.56256799
83RPS6KA50.56017239
84PRKDC0.55797684
85CSNK1D0.55650779
86CSNK2A10.55272851
87MST1R0.53656619
88PRPF4B0.52474932
89CDK30.50883570
90NME10.50709713
91PAK10.49024130
92PRKCI0.48884078
93MAP4K10.46073616
94KDR0.45654034
95ILK0.44297909
96CDK80.42849789
97FGFR40.42796619
98MAP2K30.41405946
99CDK11A0.41108532
100CDK90.39889607
101CDK190.39751197
102TRIB30.39689811
103MAPK140.39289876
104EIF2AK20.38905997
105CDK150.37365473
106CDK180.36452979
107RAF10.34889059
108KSR20.31963338
109YES10.30540285
110MET0.30372393
111AKT10.29997367
112MAPKAPK30.29279417
113PTK60.28842093
114TESK10.28173011
115GRK60.26151628
116GSK3B0.25835109
117RPS6KA10.25502858
118MAPK10.24066402
119STK160.22963355
120RPS6KB10.21949527
121MAPK90.19979195
122BTK0.17215781
123CCNB10.16830938
124PDGFRA0.16762885
125MST40.15776141
126MAPKAPK20.15492510
127MAP3K110.14253475
128MARK30.13251061
129MAPK100.12644891

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70057173
2Mismatch repair_Homo sapiens_hsa034304.17457586
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66910428
4Spliceosome_Homo sapiens_hsa030403.59290153
5Ribosome_Homo sapiens_hsa030103.47835242
6RNA transport_Homo sapiens_hsa030133.39700822
7One carbon pool by folate_Homo sapiens_hsa006702.90892040
8Cell cycle_Homo sapiens_hsa041102.88015408
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.81498084
10Nucleotide excision repair_Homo sapiens_hsa034202.68313399
11Homologous recombination_Homo sapiens_hsa034402.64913104
12Base excision repair_Homo sapiens_hsa034102.61002358
13RNA polymerase_Homo sapiens_hsa030202.37737044
14Non-homologous end-joining_Homo sapiens_hsa034502.18609030
15mRNA surveillance pathway_Homo sapiens_hsa030152.17409529
16Fanconi anemia pathway_Homo sapiens_hsa034602.09096077
17Proteasome_Homo sapiens_hsa030501.99311281
18RNA degradation_Homo sapiens_hsa030181.97396279
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94563962
20Pyrimidine metabolism_Homo sapiens_hsa002401.87256357
21Systemic lupus erythematosus_Homo sapiens_hsa053221.86773161
22p53 signaling pathway_Homo sapiens_hsa041151.63643988
23Basal transcription factors_Homo sapiens_hsa030221.50228019
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46412535
25Viral carcinogenesis_Homo sapiens_hsa052031.32694376
26Pyruvate metabolism_Homo sapiens_hsa006201.29359606
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24540302
28Epstein-Barr virus infection_Homo sapiens_hsa051691.16173830
29Antigen processing and presentation_Homo sapiens_hsa046121.16154784
30MicroRNAs in cancer_Homo sapiens_hsa052061.14457852
31Oocyte meiosis_Homo sapiens_hsa041141.12402309
32Thyroid cancer_Homo sapiens_hsa052161.10365847
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08377942
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06700694
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06616308
36HTLV-I infection_Homo sapiens_hsa051661.04181039
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02504839
38Herpes simplex infection_Homo sapiens_hsa051680.96667147
39Basal cell carcinoma_Homo sapiens_hsa052170.96532105
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94451221
41Small cell lung cancer_Homo sapiens_hsa052220.94136076
42Vitamin B6 metabolism_Homo sapiens_hsa007500.90116586
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88328563
44Purine metabolism_Homo sapiens_hsa002300.87165822
45Alcoholism_Homo sapiens_hsa050340.86754196
46Hippo signaling pathway_Homo sapiens_hsa043900.84169079
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83722478
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83219367
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83039097
50Colorectal cancer_Homo sapiens_hsa052100.82524921
51Chronic myeloid leukemia_Homo sapiens_hsa052200.77704468
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74410025
53Selenocompound metabolism_Homo sapiens_hsa004500.73829190
54TGF-beta signaling pathway_Homo sapiens_hsa043500.72588391
55Adherens junction_Homo sapiens_hsa045200.71822566
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.69256201
57Bladder cancer_Homo sapiens_hsa052190.69040008
58Biosynthesis of amino acids_Homo sapiens_hsa012300.64860323
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.63966477
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.62859704
61Arginine biosynthesis_Homo sapiens_hsa002200.59419868
62Notch signaling pathway_Homo sapiens_hsa043300.58619044
63Viral myocarditis_Homo sapiens_hsa054160.58203238
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56344057
65mTOR signaling pathway_Homo sapiens_hsa041500.56243662
66Hedgehog signaling pathway_Homo sapiens_hsa043400.55567117
67Pathways in cancer_Homo sapiens_hsa052000.53001319
68Protein export_Homo sapiens_hsa030600.52116708
69Fructose and mannose metabolism_Homo sapiens_hsa000510.51491063
70Prostate cancer_Homo sapiens_hsa052150.49990686
71Propanoate metabolism_Homo sapiens_hsa006400.49909575
72Hepatitis B_Homo sapiens_hsa051610.49555897
73Pentose phosphate pathway_Homo sapiens_hsa000300.48906875
74Proteoglycans in cancer_Homo sapiens_hsa052050.48247443
75Non-small cell lung cancer_Homo sapiens_hsa052230.47838923
76Wnt signaling pathway_Homo sapiens_hsa043100.47681132
77Acute myeloid leukemia_Homo sapiens_hsa052210.47014233
78Apoptosis_Homo sapiens_hsa042100.46718976
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46587918
80Primary immunodeficiency_Homo sapiens_hsa053400.44863722
81HIF-1 signaling pathway_Homo sapiens_hsa040660.44661073
82Legionellosis_Homo sapiens_hsa051340.44325105
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44244654
84Steroid biosynthesis_Homo sapiens_hsa001000.43908003
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43810017
86Arginine and proline metabolism_Homo sapiens_hsa003300.43161469
87Lysine degradation_Homo sapiens_hsa003100.43099204
88Endometrial cancer_Homo sapiens_hsa052130.42862328
89Insulin signaling pathway_Homo sapiens_hsa049100.42190336
90Tight junction_Homo sapiens_hsa045300.40510976
91Galactose metabolism_Homo sapiens_hsa000520.40346324
92Sulfur relay system_Homo sapiens_hsa041220.39560862
93Measles_Homo sapiens_hsa051620.35201769
94Melanoma_Homo sapiens_hsa052180.34699538
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34022588
96Pancreatic cancer_Homo sapiens_hsa052120.32701989
97Shigellosis_Homo sapiens_hsa051310.31472730
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29522045
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.27931983
100AMPK signaling pathway_Homo sapiens_hsa041520.27670868
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.25938405
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.25864841
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25528518
104Carbon metabolism_Homo sapiens_hsa012000.25441227
105Glucagon signaling pathway_Homo sapiens_hsa049220.25106003
106NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24542150
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23864886
108N-Glycan biosynthesis_Homo sapiens_hsa005100.23649710
109T cell receptor signaling pathway_Homo sapiens_hsa046600.22838395
110ErbB signaling pathway_Homo sapiens_hsa040120.22486728
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22188852
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21653439
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21625239
114FoxO signaling pathway_Homo sapiens_hsa040680.20799516
115Focal adhesion_Homo sapiens_hsa045100.20769824
116Fatty acid elongation_Homo sapiens_hsa000620.19429629
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18749200
118Influenza A_Homo sapiens_hsa051640.18554465
119Folate biosynthesis_Homo sapiens_hsa007900.18107938
120Renal cell carcinoma_Homo sapiens_hsa052110.17728916
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17608953
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17002585
123Glioma_Homo sapiens_hsa052140.16919447
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.16886219
125Hematopoietic cell lineage_Homo sapiens_hsa046400.14702725
126Renin-angiotensin system_Homo sapiens_hsa046140.14518234

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