ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine deamination (GO:0009972)	9.09450116
2	cytidine metabolic process (GO:0046087)	9.09450116
3	cytidine catabolic process (GO:0006216)	9.09450116
4	DNA deamination (GO:0045006)	8.83830509
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	8.33381151
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	7.81889252
7	negative regulation by host of viral transcription (GO:0043922)	5.44946764
8	ribosomal small subunit assembly (GO:0000028)	4.56739962
9	eosinophil chemotaxis (GO:0048245)	4.38153670
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.17417032
11	proteasome assembly (GO:0043248)	4.01074027
12	eosinophil migration (GO:0072677)	3.95312763
13	DNA demethylation (GO:0080111)	3.76226257
14	autophagic vacuole fusion (GO:0000046)	3.74873667
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.71751669
16	respiratory electron transport chain (GO:0022904)	3.71723028
17	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.69183050
18	pyrimidine nucleoside catabolic process (GO:0046135)	3.67647198
19	electron transport chain (GO:0022900)	3.66705236
20	termination of RNA polymerase III transcription (GO:0006386)	3.62269725
21	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.62269725
22	DNA dealkylation (GO:0035510)	3.62098313
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.47170801
24	maturation of SSU-rRNA (GO:0030490)	3.46780641
25	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.44854062
26	regulation of cellular amino acid metabolic process (GO:0006521)	3.44827748
27	protein complex biogenesis (GO:0070271)	3.44278268
28	negative regulation of ligase activity (GO:0051352)	3.42604500
29	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.42604500
30	negative regulation of viral genome replication (GO:0045071)	3.42307091
31	chaperone-mediated protein transport (GO:0072321)	3.41974142
32	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.40865645
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.40865645
34	organelle membrane fusion (GO:0090174)	3.40641180
35	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.39983209
36	ATP synthesis coupled proton transport (GO:0015986)	3.39983209
37	modulation by host of viral transcription (GO:0043921)	3.34333854
38	modulation by host of symbiont transcription (GO:0052472)	3.34333854
39	protein-cofactor linkage (GO:0018065)	3.31266430
40	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.30790275
41	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.27297711
42	cellular response to interleukin-15 (GO:0071350)	3.27220795
43	positive regulation of calcium-mediated signaling (GO:0050850)	3.23578376
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.23532714
45	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	3.21832037
46	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.19775264
47	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.19775264
48	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.19775264
49	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.19365964
50	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.19365964
51	protein neddylation (GO:0045116)	3.18612458
52	maturation of 5.8S rRNA (GO:0000460)	3.17667326
53	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.16332764
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.10201737
55	histone mRNA metabolic process (GO:0008334)	3.10116553
56	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.08395718
57	positive regulation of defense response to virus by host (GO:0002230)	3.05020104
58	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.04318957
59	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.04318957
60	regulation of lymphocyte chemotaxis (GO:1901623)	3.03899889
61	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.00839509
62	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00698839
63	CENP-A containing nucleosome assembly (GO:0034080)	3.00188723
64	positive regulation of ligase activity (GO:0051351)	2.99729501
65	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.99104980
66	regulation of activation of Janus kinase activity (GO:0010533)	2.98547186
67	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.95513828
68	regulation of regulatory T cell differentiation (GO:0045589)	2.94654808
69	positive regulation of T cell apoptotic process (GO:0070234)	2.94551959
70	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.93239616
71	mannosylation (GO:0097502)	2.92048920
72	chromatin remodeling at centromere (GO:0031055)	2.91840028
73	macrophage chemotaxis (GO:0048246)	2.89727127
74	positive regulation of monocyte chemotaxis (GO:0090026)	2.87734601
75	iron-sulfur cluster assembly (GO:0016226)	2.87097382
76	metallo-sulfur cluster assembly (GO:0031163)	2.87097382
77	T cell migration (GO:0072678)	2.87091839
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85760142
79	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85760142
80	NADH dehydrogenase complex assembly (GO:0010257)	2.85760142
81	regulation of chronic inflammatory response (GO:0002676)	2.85569026
82	gonadal mesoderm development (GO:0007506)	2.84004850
83	negative regulation of T cell apoptotic process (GO:0070233)	2.83206198
84	negative regulation of viral transcription (GO:0032897)	2.82435141
85	ncRNA 3-end processing (GO:0043628)	2.81036961
86	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.76442883
87	cytochrome complex assembly (GO:0017004)	2.72251793
88	positive regulation of cell cycle arrest (GO:0071158)	2.72103411
89	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.70280465
90	transcription-coupled nucleotide-excision repair (GO:0006283)	2.66822660
91	positive regulation of B cell differentiation (GO:0045579)	2.66636752
92	granulocyte activation (GO:0036230)	2.66425118
93	translation (GO:0006412)	2.66273668
94	regulation of ligase activity (GO:0051340)	2.64691219
95	spliceosomal snRNP assembly (GO:0000387)	2.63047984
96	neutrophil activation involved in immune response (GO:0002283)	2.62171906
97	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.62136031
98	pseudouridine synthesis (GO:0001522)	2.61426860
99	7-methylguanosine mRNA capping (GO:0006370)	2.60829929
100	positive regulation of interleukin-8 secretion (GO:2000484)	2.60769919

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	7.50965118
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.55171402
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.26920511
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.04445683
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.77338356
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.52827020
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.41897164
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.40216796
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.90607687
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.89938127
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.79943815
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.66812995
13	FOXP3_21729870_ChIP-Seq_TREG_Human	2.54416320
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53952832
15	E2F7_22180533_ChIP-Seq_HELA_Human	2.41186472
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.37240648
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.34664748
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.25202160
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.14099224
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.09618939
21	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.06706162
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.04814223
23	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.01070603
24	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.99534071
25	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.94123393
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.90840834
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.85754842
28	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.83440458
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.77083383
30	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.74628946
31	MYC_18940864_ChIP-ChIP_HL60_Human	1.73994063
32	MYB_26560356_Chip-Seq_TH2_Human	1.64958170
33	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.61930656
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61660869
35	VDR_22108803_ChIP-Seq_LS180_Human	1.60566383
36	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.59389153
37	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.56983448
38	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.54221579
39	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.52852250
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.49764080
41	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.46815537
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.45249384
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.44402185
44	DCP1A_22483619_ChIP-Seq_HELA_Human	1.44265286
45	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.43123288
46	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.40098930
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.38758600
48	GABP_19822575_ChIP-Seq_HepG2_Human	1.38662351
49	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.36892083
50	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.36715310
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.33654431
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.33252308
53	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.30781222
54	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.28037056
55	ZNF274_21170338_ChIP-Seq_K562_Hela	1.26160719
56	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.24360769
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.24167587
58	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.22805888
59	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.22717939
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.21900987
61	TP53_22573176_ChIP-Seq_HFKS_Human	1.18984459
62	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17507009
63	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.16471222
64	XRN2_22483619_ChIP-Seq_HELA_Human	1.14893538
65	GATA3_27048872_Chip-Seq_THYMUS_Human	1.13856430
66	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.12167745
67	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.11558344
68	GATA3_26560356_Chip-Seq_TH2_Human	1.09130859
69	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.08773607
70	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.08592729
71	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.04905542
72	GATA1_22025678_ChIP-Seq_K562_Human	1.04042107
73	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.01124551
74	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.00965931
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00950012
76	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.00561507
77	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00550979
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00550979
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.98247112
80	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.97509470
81	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.92447684
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92065106
83	AR_20517297_ChIP-Seq_VCAP_Human	0.91770226
84	CIITA_25753668_ChIP-Seq_RAJI_Human	0.88445056
85	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.86568584
86	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.85796109
87	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.85326947
88	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.84110935
89	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.83265417
90	SPI1_23547873_ChIP-Seq_NB4_Human	0.82886376
91	MYB_26560356_Chip-Seq_TH1_Human	0.82205217
92	MAF_26560356_Chip-Seq_TH2_Human	0.82188069
93	IGF1R_20145208_ChIP-Seq_DFB_Human	0.82130373
94	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.81985037
95	BCL6_27268052_Chip-Seq_Bcells_Human	0.81765584
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.80320669
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.80127362
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.78699241
99	HTT_18923047_ChIP-ChIP_STHdh_Human	0.78281335
100	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.77580142

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	5.04063111
2	MP0006292_abnormal_olfactory_placode	3.38052928
3	MP0003763_abnormal_thymus_physiology	3.26065202
4	MP0004147_increased_porphyrin_level	3.21141531
5	MP0009333_abnormal_splenocyte_physiolog	2.96267951
6	MP0003786_premature_aging	2.63364561
7	MP0008877_abnormal_DNA_methylation	2.58846589
8	MP0001873_stomach_inflammation	2.41668522
9	MP0001835_abnormal_antigen_presentation	2.32194717
10	MP0009379_abnormal_foot_pigmentation	2.25885353
11	MP0001188_hyperpigmentation	2.22600951
12	MP0000372_irregular_coat_pigmentation	2.16853789
13	MP0009785_altered_susceptibility_to	2.16242278
14	MP0006072_abnormal_retinal_apoptosis	2.13200012
15	MP0003806_abnormal_nucleotide_metabolis	2.11829840
16	MP0002148_abnormal_hypersensitivity_rea	2.09139085
17	MP0008995_early_reproductive_senescence	2.07880891
18	MP0005084_abnormal_gallbladder_morpholo	2.02719604
19	MP0001800_abnormal_humoral_immune	2.02416992
20	MP0005075_abnormal_melanosome_morpholog	1.99445613
21	MP0005000_abnormal_immune_tolerance	1.85498545
22	MP0002723_abnormal_immune_serum	1.78764756
23	MP0002420_abnormal_adaptive_immunity	1.77780102
24	MP0004957_abnormal_blastocyst_morpholog	1.73913885
25	MP0001819_abnormal_immune_cell	1.70451977
26	MP0006082_CNS_inflammation	1.69930244
27	MP0003693_abnormal_embryo_hatching	1.69572736
28	MP0001919_abnormal_reproductive_system	1.66735980
29	MP0002398_abnormal_bone_marrow	1.63465334
30	MP0000465_gastrointestinal_hemorrhage	1.62188714
31	MP0005025_abnormal_response_to	1.58319792
32	MP0002166_altered_tumor_susceptibility	1.53874883
33	MP0000716_abnormal_immune_system	1.53736388
34	MP0005410_abnormal_fertilization	1.49989928
35	MP0003011_delayed_dark_adaptation	1.49247488
36	MP0002837_dystrophic_cardiac_calcinosis	1.45290513
37	MP0002452_abnormal_antigen_presenting	1.42768197
38	MP0002006_tumorigenesis	1.41434725
39	MP0003646_muscle_fatigue	1.37124247
40	MP0000689_abnormal_spleen_morphology	1.36959617
41	MP0000703_abnormal_thymus_morphology	1.36288634
42	MP0002277_abnormal_respiratory_mucosa	1.33121004
43	MP0002722_abnormal_immune_system	1.31458443
44	MP0002102_abnormal_ear_morphology	1.30015107
45	MP0005387_immune_system_phenotype	1.29059522
46	MP0001790_abnormal_immune_system	1.29059522
47	MP0003567_abnormal_fetal_cardiomyocyte	1.28950716
48	MP0002429_abnormal_blood_cell	1.26476964
49	MP0010094_abnormal_chromosome_stability	1.25890259
50	MP0005389_reproductive_system_phenotype	1.25179884
51	MP0002234_abnormal_pharynx_morphology	1.24470662
52	MP0008058_abnormal_DNA_repair	1.21875688
53	MP0004145_abnormal_muscle_electrophysio	1.20821229
54	MP0002876_abnormal_thyroid_physiology	1.17426288
55	MP0002405_respiratory_system_inflammati	1.15073520
56	MP0008872_abnormal_physiological_respon	1.11603017
57	MP0005253_abnormal_eye_physiology	1.10246414
58	MP0002163_abnormal_gland_morphology	1.09116699
59	MP0004142_abnormal_muscle_tone	1.09024719
60	MP0003866_abnormal_defecation	1.08504860
61	MP0010155_abnormal_intestine_physiology	1.07111246
62	MP0003183_abnormal_peptide_metabolism	1.05388795
63	MP0005379_endocrine/exocrine_gland_phen	1.05339417
64	MP0001845_abnormal_inflammatory_respons	1.03940868
65	MP0001293_anophthalmia	1.03381846
66	MP0003448_altered_tumor_morphology	1.01710598
67	MP0008932_abnormal_embryonic_tissue	0.98164030
68	MP0002138_abnormal_hepatobiliary_system	0.92241478
69	MP0002019_abnormal_tumor_incidence	0.91087276
70	MP0000685_abnormal_immune_system	0.90832062
71	MP0006276_abnormal_autonomic_nervous	0.89531190
72	MP0000639_abnormal_adrenal_gland	0.89473076
73	MP0002396_abnormal_hematopoietic_system	0.88315631
74	MP0005360_urolithiasis	0.85044157
75	MP0001968_abnormal_touch/_nociception	0.84423737
76	MP0002736_abnormal_nociception_after	0.83892632
77	MP0002132_abnormal_respiratory_system	0.81680181
78	MP0001764_abnormal_homeostasis	0.80586554
79	MP0002933_joint_inflammation	0.80111586
80	MP0009643_abnormal_urine_homeostasis	0.79797960
81	MP0005174_abnormal_tail_pigmentation	0.77463702
82	MP0003718_maternal_effect	0.76783944
83	MP0003252_abnormal_bile_duct	0.76724191
84	MP0005377_hearing/vestibular/ear_phenot	0.76561809
85	MP0003878_abnormal_ear_physiology	0.76561809
86	MP0008789_abnormal_olfactory_epithelium	0.75934644
87	MP0000569_abnormal_digit_pigmentation	0.75308638
88	MP0001542_abnormal_bone_strength	0.74762617
89	MP0009763_increased_sensitivity_to	0.74292408
90	MP0002095_abnormal_skin_pigmentation	0.70457075
91	MP0001929_abnormal_gametogenesis	0.69487375
92	MP0002693_abnormal_pancreas_physiology	0.68685596
93	MP0005551_abnormal_eye_electrophysiolog	0.68486132
94	MP0001905_abnormal_dopamine_level	0.67173934
95	MP0001145_abnormal_male_reproductive	0.66923036
96	MP0001727_abnormal_embryo_implantation	0.66522604
97	MP0003787_abnormal_imprinting	0.66345379
98	MP0002160_abnormal_reproductive_system	0.66136841
99	MP0003186_abnormal_redox_activity	0.65835788
100	MP0006036_abnormal_mitochondrial_physio	0.64908533

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	5.84401896
2	T lymphocytopenia (HP:0005403)	4.92416831
3	Acute necrotizing encephalopathy (HP:0006965)	4.65533417
4	Abnormality of T cell number (HP:0011839)	4.49338355
5	Mitochondrial inheritance (HP:0001427)	4.35635538
6	Abnormal mitochondria in muscle tissue (HP:0008316)	4.28013549
7	Increased CSF lactate (HP:0002490)	4.00272977
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.90493258
9	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.90493258
10	Hepatocellular necrosis (HP:0001404)	3.89298052
11	Acute encephalopathy (HP:0006846)	3.77945233
12	IgG deficiency (HP:0004315)	3.74218594
13	Progressive macrocephaly (HP:0004481)	3.67053540
14	Oral leukoplakia (HP:0002745)	3.38471746
15	Abnormality of T cells (HP:0002843)	3.36170107
16	Increased intramyocellular lipid droplets (HP:0012240)	3.33629699
17	Hepatic necrosis (HP:0002605)	3.30894864
18	Cerebral edema (HP:0002181)	3.21646323
19	Stomatitis (HP:0010280)	3.16312969
20	Severe combined immunodeficiency (HP:0004430)	3.08442410
21	Anomalous pulmonary venous return (HP:0010772)	2.94198018
22	Lactic acidosis (HP:0003128)	2.93693496
23	Increased hepatocellular lipid droplets (HP:0006565)	2.89572097
24	Cutaneous melanoma (HP:0012056)	2.86516391
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.85991460
26	Increased serum lactate (HP:0002151)	2.85108284
27	Increased muscle lipid content (HP:0009058)	2.82173083
28	3-Methylglutaconic aciduria (HP:0003535)	2.82148525
29	Carpal bone hypoplasia (HP:0001498)	2.73207073
30	Lipid accumulation in hepatocytes (HP:0006561)	2.71530394
31	Pancytopenia (HP:0001876)	2.69681474
32	Hypoproteinemia (HP:0003075)	2.68619288
33	Severe global developmental delay (HP:0011344)	2.62481821
34	Chronic diarrhea (HP:0002028)	2.60441265
35	Abnormality of the pulmonary veins (HP:0011718)	2.58506266
36	Combined immunodeficiency (HP:0005387)	2.58219264
37	Progressive inability to walk (HP:0002505)	2.49765859
38	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.49755832
39	Autoimmune hemolytic anemia (HP:0001890)	2.49532959
40	Lethargy (HP:0001254)	2.48990940
41	Optic disc pallor (HP:0000543)	2.47438266
42	Abnormal number of erythroid precursors (HP:0012131)	2.46264365
43	Respiratory failure (HP:0002878)	2.45992922
44	Congenital stationary night blindness (HP:0007642)	2.35911716
45	Leukodystrophy (HP:0002415)	2.31028070
46	Exercise intolerance (HP:0003546)	2.23929226
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.21339020
48	Abnormality of eosinophils (HP:0001879)	2.19392407
49	Palpitations (HP:0001962)	2.18594683
50	Type I transferrin isoform profile (HP:0003642)	2.13178142
51	Amyotrophic lateral sclerosis (HP:0007354)	2.11559389
52	Abnormality of the prostate (HP:0008775)	2.11447201
53	Abnormality of cells of the erythroid lineage (HP:0012130)	2.11128970
54	IgM deficiency (HP:0002850)	2.10617857
55	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.10154522
56	Renal Fanconi syndrome (HP:0001994)	2.07499175
57	Gonadal dysgenesis (HP:0000133)	2.06412862
58	Delayed CNS myelination (HP:0002188)	2.05929737
59	Cerebral palsy (HP:0100021)	2.03476381
60	Recurrent bronchitis (HP:0002837)	2.03069401
61	Molar tooth sign on MRI (HP:0002419)	2.00098366
62	Abnormality of midbrain morphology (HP:0002418)	2.00098366
63	Abnormal rod and cone electroretinograms (HP:0008323)	1.99720310
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.99204120
65	Recurrent viral infections (HP:0004429)	1.96669414
66	Female pseudohermaphroditism (HP:0010458)	1.94782700
67	Methylmalonic aciduria (HP:0012120)	1.94542912
68	Pustule (HP:0200039)	1.93780076
69	Attenuation of retinal blood vessels (HP:0007843)	1.93562262
70	Confusion (HP:0001289)	1.93273636
71	Chronic mucocutaneous candidiasis (HP:0002728)	1.93214453
72	Recurrent cutaneous fungal infections (HP:0011370)	1.93214453
73	Absent thumb (HP:0009777)	1.93122203
74	Dicarboxylic aciduria (HP:0003215)	1.92912758
75	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.92912758
76	Abnormality of the labia minora (HP:0012880)	1.92501436
77	Thyroiditis (HP:0100646)	1.90665201
78	Abolished electroretinogram (ERG) (HP:0000550)	1.90262852
79	Rib fusion (HP:0000902)	1.88979786
80	Abnormality of T cell physiology (HP:0011840)	1.87360978
81	Reduced antithrombin III activity (HP:0001976)	1.85841793
82	Fused cervical vertebrae (HP:0002949)	1.83978532
83	Congenital, generalized hypertrichosis (HP:0004540)	1.83598885
84	CNS demyelination (HP:0007305)	1.83081027
85	Hypoplasia of the thymus (HP:0000778)	1.81946228
86	Abnormality of B cell number (HP:0010975)	1.80569883
87	B lymphocytopenia (HP:0010976)	1.80026650
88	Increased IgM level (HP:0003496)	1.78976649
89	Paralysis (HP:0003470)	1.78904347
90	Emotional lability (HP:0000712)	1.77790099
91	Decreased central vision (HP:0007663)	1.75982965
92	Hypomagnesemia (HP:0002917)	1.75448440
93	Inability to walk (HP:0002540)	1.75345285
94	Lymphopenia (HP:0001888)	1.74880930
95	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.74531298
96	Cellular immunodeficiency (HP:0005374)	1.74332236
97	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.72325250
98	Eosinophilia (HP:0001880)	1.72110472
99	Abnormality of magnesium homeostasis (HP:0004921)	1.70341420
100	Macrocytic anemia (HP:0001972)	1.69188843

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.01727275
2	MST4	3.79891031
3	KDR	3.35803053
4	NUAK1	2.78464902
5	TESK2	2.70230561
6	VRK2	2.69545050
7	NLK	2.55807699
8	CDC7	2.50869149
9	TLK1	2.47237192
10	STK16	2.37508971
11	ZAK	2.18412584
12	ITK	1.99897380
13	EIF2AK3	1.99428100
14	SRPK1	1.99080172
15	BRSK2	1.97990967
16	VRK1	1.97564058
17	ADRBK2	1.94895401
18	WNK4	1.93412717
19	BCKDK	1.93269952
20	CDK19	1.86811120
21	TAOK3	1.83223155
22	MAP4K1	1.59208475
23	MATK	1.56964343
24	PDK2	1.26588781
25	TEC	1.23945768
26	SYK	1.22502250
27	SCYL2	1.19962423
28	PINK1	1.19415938
29	ARAF	1.15202881
30	BUB1	1.05461105
31	CDK3	1.05216802
32	FES	1.04009778
33	MAP3K11	1.02422491
34	CSNK1G1	0.98075538
35	STK39	0.96782149
36	ATR	0.96743064
37	RPS6KA4	0.96401106
38	EIF2AK1	0.91610477
39	AURKA	0.91171650
40	OXSR1	0.87973642
41	IKBKB	0.87822287
42	RPS6KA5	0.85886346
43	BRSK1	0.85117891
44	PLK1	0.84895553
45	PRKCQ	0.84498127
46	FGFR1	0.83786389
47	MAP2K2	0.80643866
48	ACVR1B	0.79540946
49	TIE1	0.79349826
50	PLK3	0.78107858
51	PIM2	0.77529829
52	PASK	0.77070908
53	BRAF	0.76426929
54	LCK	0.74011158
55	DAPK2	0.73002822
56	WNK3	0.71547050
57	GRK7	0.70636942
58	MAP3K12	0.69970043
59	CSK	0.69669067
60	PIM1	0.69383098
61	CDK4	0.69357227
62	AURKB	0.68775508
63	IKBKE	0.66750224
64	MAPKAPK3	0.66452653
65	BTK	0.66270526
66	GRK1	0.64185175
67	OBSCN	0.63167039
68	DAPK1	0.62243459
69	CSF1R	0.59930527
70	NME1	0.59792986
71	LIMK1	0.59236873
72	ZAP70	0.58698628
73	TNK2	0.58287422
74	NEK2	0.56211705
75	NTRK1	0.55306642
76	DYRK2	0.55096364
77	LYN	0.54917036
78	PIK3CA	0.54739386
79	BMPR1B	0.52181184
80	KIT	0.52097304
81	GRK6	0.51755817
82	MAP4K2	0.49364525
83	CSNK2A1	0.48551292
84	STK38L	0.48412171
85	PAK1	0.45526764
86	PLK4	0.44793123
87	CHEK2	0.43234559
88	INSRR	0.43205791
89	PLK2	0.37904194
90	MAPK13	0.37240720
91	BLK	0.35814210
92	DYRK1A	0.35300256
93	CSNK2A2	0.33553374
94	WEE1	0.31205853
95	DAPK3	0.30906735
96	INSR	0.30109927
97	PRKCA	0.29674729
98	EPHA4	0.27838711
99	MAPK7	0.27411758
100	MAP3K9	0.25491070

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.98908294
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.77165218
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.65348546
4	Ribosome_Homo sapiens_hsa03010	3.30839196
5	Parkinsons disease_Homo sapiens_hsa05012	3.26671313
6	RNA polymerase_Homo sapiens_hsa03020	3.08913499
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.80504998
8	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.58913280
9	Homologous recombination_Homo sapiens_hsa03440	2.50547697
10	DNA replication_Homo sapiens_hsa03030	2.49152162
11	Huntingtons disease_Homo sapiens_hsa05016	2.13718806
12	Alzheimers disease_Homo sapiens_hsa05010	2.09876472
13	Antigen processing and presentation_Homo sapiens_hsa04612	2.08043161
14	Protein export_Homo sapiens_hsa03060	2.02372042
15	Mismatch repair_Homo sapiens_hsa03430	2.01311258
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.87243171
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.65620131
18	Spliceosome_Homo sapiens_hsa03040	1.62119133
19	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.61003413
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.60615173
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58164462
22	Graft-versus-host disease_Homo sapiens_hsa05332	1.58026647
23	Base excision repair_Homo sapiens_hsa03410	1.50286701
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.44702756
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.43318781
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.42043267
27	Allograft rejection_Homo sapiens_hsa05330	1.40878255
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.40342674
29	Rheumatoid arthritis_Homo sapiens_hsa05323	1.36983993
30	RNA degradation_Homo sapiens_hsa03018	1.34360538
31	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.30540627
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.26742300
33	RNA transport_Homo sapiens_hsa03013	1.25227877
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.21813101
35	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.18362643
36	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.13723609
37	Purine metabolism_Homo sapiens_hsa00230	1.12600190
38	Sulfur metabolism_Homo sapiens_hsa00920	1.10237567
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.09102708
40	Basal transcription factors_Homo sapiens_hsa03022	1.05471781
41	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.00661397
42	Linoleic acid metabolism_Homo sapiens_hsa00591	0.98772959
43	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95141248
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.94944927
45	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.93411506
46	Propanoate metabolism_Homo sapiens_hsa00640	0.92036817
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.90488982
48	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.87939347
49	Peroxisome_Homo sapiens_hsa04146	0.82836293
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.80988205
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79211612
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78185018
53	Asthma_Homo sapiens_hsa05310	0.72484375
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.72182631
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.61941717
56	One carbon pool by folate_Homo sapiens_hsa00670	0.60034094
57	Metabolic pathways_Homo sapiens_hsa01100	0.59890138
58	mRNA surveillance pathway_Homo sapiens_hsa03015	0.58210796
59	Regulation of autophagy_Homo sapiens_hsa04140	0.57563260
60	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.56529208
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.56226811
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55873987
63	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.51225582
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.51151238
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50515522
66	Fatty acid elongation_Homo sapiens_hsa00062	0.49785828
67	Measles_Homo sapiens_hsa05162	0.49710507
68	Phototransduction_Homo sapiens_hsa04744	0.46090858
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.45996987
70	Selenocompound metabolism_Homo sapiens_hsa00450	0.42979655
71	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42856675
72	Viral myocarditis_Homo sapiens_hsa05416	0.39722376
73	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.38004268
74	Shigellosis_Homo sapiens_hsa05131	0.35675592
75	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.35114689
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.33046278
77	Butanoate metabolism_Homo sapiens_hsa00650	0.31729988
78	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.31683337
79	Olfactory transduction_Homo sapiens_hsa04740	0.31135799
80	Alcoholism_Homo sapiens_hsa05034	0.31051219
81	Cell cycle_Homo sapiens_hsa04110	0.30693379
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.30220311
83	Herpes simplex infection_Homo sapiens_hsa05168	0.28208107
84	Arginine biosynthesis_Homo sapiens_hsa00220	0.28023300
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.27786110
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.27768692
87	Salmonella infection_Homo sapiens_hsa05132	0.27690444
88	Retinol metabolism_Homo sapiens_hsa00830	0.27447511
89	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.25235663
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.23062135
91	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.22988178
92	p53 signaling pathway_Homo sapiens_hsa04115	0.22441352
93	Glutathione metabolism_Homo sapiens_hsa00480	0.21944382
94	Taste transduction_Homo sapiens_hsa04742	0.21557458
95	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.18521395
96	Oocyte meiosis_Homo sapiens_hsa04114	0.17403372
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.17165257
98	Caffeine metabolism_Homo sapiens_hsa00232	0.16527914
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.15513632
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.15060660

SERBP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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