ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.45128679
2	maturation of SSU-rRNA (GO:0030490)	5.91382133
3	behavioral response to nicotine (GO:0035095)	5.62341230
4	viral transcription (GO:0019083)	5.54374183
5	translational termination (GO:0006415)	5.27738327
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.01153028
7	NADH dehydrogenase complex assembly (GO:0010257)	5.01153028
8	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.01153028
9	protein complex biogenesis (GO:0070271)	4.75558474
10	pseudouridine synthesis (GO:0001522)	4.74079559
11	chaperone-mediated protein transport (GO:0072321)	4.63285307
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.58354239
13	respiratory chain complex IV assembly (GO:0008535)	4.57490642
14	indolalkylamine metabolic process (GO:0006586)	4.53012815
15	cotranslational protein targeting to membrane (GO:0006613)	4.52918667
16	DNA deamination (GO:0045006)	4.48882481
17	protein targeting to ER (GO:0045047)	4.44420887
18	mitochondrial respiratory chain complex assembly (GO:0033108)	4.41035150
19	ATP synthesis coupled proton transport (GO:0015986)	4.39076513
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.39076513
21	translational elongation (GO:0006414)	4.30254213
22	rRNA modification (GO:0000154)	4.29964000
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.21037302
24	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.20051517
25	transcription from mitochondrial promoter (GO:0006390)	4.20038893
26	peptidyl-histidine modification (GO:0018202)	4.17398395
27	protein localization to endoplasmic reticulum (GO:0070972)	4.17171271
28	ribosomal small subunit biogenesis (GO:0042274)	4.16392609
29	negative regulation of inclusion body assembly (GO:0090084)	4.07154099
30	cytochrome complex assembly (GO:0017004)	4.06687667
31	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.02810400
32	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.02637894
33	inner mitochondrial membrane organization (GO:0007007)	3.93554473
34	ribosomal large subunit biogenesis (GO:0042273)	3.93035547
35	cellular protein complex disassembly (GO:0043624)	3.90741414
36	ribosomal small subunit assembly (GO:0000028)	3.85864175
37	translational initiation (GO:0006413)	3.81655368
38	protein neddylation (GO:0045116)	3.80657884
39	rRNA methylation (GO:0031167)	3.71586651
40	viral life cycle (GO:0019058)	3.70585784
41	water-soluble vitamin biosynthetic process (GO:0042364)	3.62885193
42	kynurenine metabolic process (GO:0070189)	3.57956217
43	translation (GO:0006412)	3.51584503
44	protein complex disassembly (GO:0043241)	3.38836791
45	mitochondrial RNA metabolic process (GO:0000959)	3.33208872
46	regulation of inclusion body assembly (GO:0090083)	3.32292141
47	indole-containing compound catabolic process (GO:0042436)	3.29454144
48	indolalkylamine catabolic process (GO:0046218)	3.29454144
49	tryptophan catabolic process (GO:0006569)	3.29454144
50	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.28705137
51	DNA demethylation (GO:0080111)	3.27075677
52	regulation of male gonad development (GO:2000018)	3.21763450
53	macromolecular complex disassembly (GO:0032984)	3.20422463
54	dendritic spine morphogenesis (GO:0060997)	3.19322431
55	maturation of 5.8S rRNA (GO:0000460)	3.18837114
56	meiotic chromosome segregation (GO:0045132)	3.18740961
57	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.16472442
58	acrosome reaction (GO:0007340)	3.06046447
59	opioid receptor signaling pathway (GO:0038003)	3.05957232
60	indole-containing compound metabolic process (GO:0042430)	3.05937155
61	DNA double-strand break processing (GO:0000729)	3.02663996
62	amine catabolic process (GO:0009310)	3.01799564
63	cellular biogenic amine catabolic process (GO:0042402)	3.01799564
64	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.99855571
65	respiratory electron transport chain (GO:0022904)	2.99786972
66	electron transport chain (GO:0022900)	2.99191247
67	cerebral cortex radially oriented cell migration (GO:0021799)	2.98467136
68	DNA integration (GO:0015074)	2.96721692
69	positive regulation of T cell differentiation in thymus (GO:0033089)	2.95267532
70	mannosylation (GO:0097502)	2.94948818
71	regulation of timing of cell differentiation (GO:0048505)	2.94450879
72	pyrimidine nucleotide catabolic process (GO:0006244)	2.93104748
73	mRNA catabolic process (GO:0006402)	2.92656032
74	cellular response to interferon-beta (GO:0035458)	2.91248166
75	protein targeting to mitochondrion (GO:0006626)	2.89391654
76	cullin deneddylation (GO:0010388)	2.87446911
77	regulation of development, heterochronic (GO:0040034)	2.85946654
78	negative regulation of gene silencing (GO:0060969)	2.84212476
79	protein targeting to membrane (GO:0006612)	2.83918112
80	cellular component biogenesis (GO:0044085)	2.80323229
81	cellular biogenic amine biosynthetic process (GO:0042401)	2.77595478
82	protein localization to mitochondrion (GO:0070585)	2.76097308
83	L-ascorbic acid metabolic process (GO:0019852)	2.74769788
84	kidney morphogenesis (GO:0060993)	2.73358707
85	leukocyte migration involved in inflammatory response (GO:0002523)	2.72617951
86	negative regulation of cell aging (GO:0090344)	2.71705731
87	RNA catabolic process (GO:0006401)	2.66777438
88	cellular response to exogenous dsRNA (GO:0071360)	2.66088851
89	establishment of protein localization to mitochondrion (GO:0072655)	2.65476696
90	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.64662445
91	sympathetic nervous system development (GO:0048485)	2.64519470
92	ATP biosynthetic process (GO:0006754)	2.63680364
93	righting reflex (GO:0060013)	2.62160458
94	DNA replication-dependent nucleosome assembly (GO:0006335)	2.61833348
95	DNA replication-dependent nucleosome organization (GO:0034723)	2.61833348
96	neuron fate determination (GO:0048664)	2.59771168
97	adenosine metabolic process (GO:0046085)	2.58433738
98	somite development (GO:0061053)	2.56481822
99	proton transport (GO:0015992)	2.55954186
100	central nervous system projection neuron axonogenesis (GO:0021952)	2.55213921

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.45328561
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.20338315
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.03003868
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.52099491
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.24913531
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.24411846
7	IRF1_19129219_ChIP-ChIP_H3396_Human	3.21680498
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.14689695
9	VDR_22108803_ChIP-Seq_LS180_Human	2.93199063
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.71507074
11	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.52472450
12	MYC_18940864_ChIP-ChIP_HL60_Human	2.46008495
13	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.31955389
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.30985372
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.24943197
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22451529
17	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.10211054
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.09162807
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.07306675
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.05505309
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.96014538
22	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.94853320
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.94672008
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94328022
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.93999786
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.88482409
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86628856
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.84536839
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.84492525
30	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.76851780
31	EWS_26573619_Chip-Seq_HEK293_Human	1.71963708
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.71288367
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.68886381
34	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67356766
35	FUS_26573619_Chip-Seq_HEK293_Human	1.63556733
36	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.63117857
37	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.61861293
38	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.58357388
39	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.57400160
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.57138185
41	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.53600898
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53232257
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.52804611
44	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.51219935
45	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.49119221
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.48576365
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47739958
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.46720893
49	AR_21572438_ChIP-Seq_LNCaP_Human	1.46068561
50	ELK1_19687146_ChIP-ChIP_HELA_Human	1.44421449
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44307917
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.42162859
53	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.40937022
54	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.39344258
55	P300_19829295_ChIP-Seq_ESCs_Human	1.37998177
56	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28865009
57	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26812956
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.26338689
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18951753
60	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.18664240
61	HTT_18923047_ChIP-ChIP_STHdh_Human	1.16879505
62	NCOR_22424771_ChIP-Seq_293T_Human	1.16779240
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.14768184
64	AR_25329375_ChIP-Seq_VCAP_Human	1.14633440
65	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14146935
66	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.13012923
67	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.12757317
68	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.08156489
69	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.07115964
70	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.06051997
71	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.05162841
72	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99112647
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.98978088
74	GABP_19822575_ChIP-Seq_HepG2_Human	0.97395987
75	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.97345821
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97130091
77	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96404289
78	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.94830727
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.94830727
80	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.94592329
81	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94380129
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94380129
83	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93791427
84	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.92533916
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.92440386
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.91474175
87	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.90855965
88	ER_23166858_ChIP-Seq_MCF-7_Human	0.90600680
89	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.89774228
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89646255
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89607708
92	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89607708
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.89473374
94	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.88807168
95	XRN2_22483619_ChIP-Seq_HELA_Human	0.87937951
96	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.87609228
97	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.86140457
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.86126168
99	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.85107352
100	IGF1R_20145208_ChIP-Seq_DFB_Human	0.83771107

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.88096983
2	MP0000566_synostosis	4.36722251
3	MP0009379_abnormal_foot_pigmentation	4.10204773
4	MP0006292_abnormal_olfactory_placode	3.92597214
5	MP0004145_abnormal_muscle_electrophysio	3.52342299
6	MP0005423_abnormal_somatic_nervous	3.26927869
7	MP0008875_abnormal_xenobiotic_pharmacok	3.00002152
8	MP0008058_abnormal_DNA_repair	2.74682095
9	MP0002653_abnormal_ependyma_morphology	2.55879206
10	MP0002102_abnormal_ear_morphology	2.22431343
11	MP0003718_maternal_effect	2.19967626
12	MP0005409_darkened_coat_color	2.15927327
13	MP0005646_abnormal_pituitary_gland	2.13742721
14	MP0002751_abnormal_autonomic_nervous	1.82938846
15	MP0002249_abnormal_larynx_morphology	1.73180198
16	MP0001529_abnormal_vocalization	1.71031423
17	MP0000516_abnormal_urinary_system	1.70507732
18	MP0005367_renal/urinary_system_phenotyp	1.70507732
19	MP0006072_abnormal_retinal_apoptosis	1.66358861
20	MP0008872_abnormal_physiological_respon	1.63788773
21	MP0003315_abnormal_perineum_morphology	1.62408286
22	MP0005623_abnormal_meninges_morphology	1.58832763
23	MP0002160_abnormal_reproductive_system	1.53032784
24	MP0009745_abnormal_behavioral_response	1.44623853
25	MP0000537_abnormal_urethra_morphology	1.44000045
26	MP0006276_abnormal_autonomic_nervous	1.38891267
27	MP0000631_abnormal_neuroendocrine_gland	1.36973318
28	MP0009053_abnormal_anal_canal	1.34952314
29	MP0002184_abnormal_innervation	1.30026131
30	MP0004742_abnormal_vestibular_system	1.28754075
31	MP0009780_abnormal_chondrocyte_physiolo	1.27549029
32	MP0002234_abnormal_pharynx_morphology	1.25294418
33	MP0000049_abnormal_middle_ear	1.25098481
34	MP0002127_abnormal_cardiovascular_syste	1.23465273
35	MP0002928_abnormal_bile_duct	1.20248389
36	MP0003186_abnormal_redox_activity	1.20167637
37	MP0005410_abnormal_fertilization	1.19303003
38	MP0005084_abnormal_gallbladder_morpholo	1.18965732
39	MP0001879_abnormal_lymphatic_vessel	1.18723030
40	MP0005551_abnormal_eye_electrophysiolog	1.18026562
41	MP0005645_abnormal_hypothalamus_physiol	1.17506655
42	MP0001905_abnormal_dopamine_level	1.17337588
43	MP0003011_delayed_dark_adaptation	1.14233377
44	MP0004147_increased_porphyrin_level	1.12580919
45	MP0003938_abnormal_ear_development	1.11839581
46	MP0002638_abnormal_pupillary_reflex	1.09349542
47	MP0003806_abnormal_nucleotide_metabolis	1.09035383
48	MP0004142_abnormal_muscle_tone	1.08228336
49	MP0002064_seizures	1.05557981
50	MP0000026_abnormal_inner_ear	1.04011709
51	MP0001486_abnormal_startle_reflex	1.02972214
52	MP0000778_abnormal_nervous_system	1.02089738
53	MP0002736_abnormal_nociception_after	1.01545733
54	MP0000955_abnormal_spinal_cord	1.00631015
55	MP0001440_abnormal_grooming_behavior	0.99184613
56	MP0003693_abnormal_embryo_hatching	0.96231568
57	MP0004085_abnormal_heartbeat	0.93457659
58	MP0003755_abnormal_palate_morphology	0.93122634
59	MP0002752_abnormal_somatic_nervous	0.87828560
60	MP0002938_white_spotting	0.86379188
61	MP0000372_irregular_coat_pigmentation	0.86345853
62	MP0001664_abnormal_digestion	0.85494927
63	MP0005389_reproductive_system_phenotype	0.85409538
64	MP0003638_abnormal_response/metabolism_	0.84979083
65	MP0003283_abnormal_digestive_organ	0.84426473
66	MP0010307_abnormal_tumor_latency	0.83249670
67	MP0002735_abnormal_chemical_nociception	0.82707618
68	MP0001963_abnormal_hearing_physiology	0.82678675
69	MP0009250_abnormal_appendicular_skeleto	0.81706874
70	MP0001929_abnormal_gametogenesis	0.81699008
71	MP0001764_abnormal_homeostasis	0.80361756
72	MP0008789_abnormal_olfactory_epithelium	0.79670580
73	MP0010094_abnormal_chromosome_stability	0.79627449
74	MP0001542_abnormal_bone_strength	0.77731171
75	MP0002932_abnormal_joint_morphology	0.76996524
76	MP0005253_abnormal_eye_physiology	0.75812410
77	MP0002210_abnormal_sex_determination	0.74711849
78	MP0002116_abnormal_craniofacial_bone	0.72717940
79	MP0002063_abnormal_learning/memory/cond	0.70450327
80	MP0002837_dystrophic_cardiac_calcinosis	0.70360772
81	MP0003937_abnormal_limbs/digits/tail_de	0.69265303
82	MP0002067_abnormal_sensory_capabilities	0.67973290
83	MP0001968_abnormal_touch/_nociception	0.64760101
84	MP0001986_abnormal_taste_sensitivity	0.64300157
85	MP0004233_abnormal_muscle_weight	0.63260835
86	MP0005448_abnormal_energy_balance	0.63253276
87	MP0004043_abnormal_pH_regulation	0.62446421
88	MP0002272_abnormal_nervous_system	0.62248561
89	MP0002882_abnormal_neuron_morphology	0.61622879
90	MP0000653_abnormal_sex_gland	0.61274352
91	MP0000427_abnormal_hair_cycle	0.61172924
92	MP0003861_abnormal_nervous_system	0.60046186
93	MP0006036_abnormal_mitochondrial_physio	0.59042585
94	MP0003567_abnormal_fetal_cardiomyocyte	0.57967725
95	MP0001145_abnormal_male_reproductive	0.57715608
96	MP0003786_premature_aging	0.57706559
97	MP0003866_abnormal_defecation	0.57175773
98	MP0000647_abnormal_sebaceous_gland	0.56790589
99	MP0004885_abnormal_endolymph	0.56735044
100	MP0000534_abnormal_ureter_morphology	0.56659999

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.80994632
2	Mitochondrial inheritance (HP:0001427)	4.00192125
3	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.92794478
4	Long nose (HP:0003189)	3.85381490
5	Acute necrotizing encephalopathy (HP:0006965)	3.76100052
6	Conical tooth (HP:0000698)	3.62969805
7	Delayed CNS myelination (HP:0002188)	3.57935937
8	Testicular atrophy (HP:0000029)	3.48010411
9	Hyperventilation (HP:0002883)	3.46313757
10	Hepatocellular necrosis (HP:0001404)	3.45587628
11	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.44830280
12	Increased hepatocellular lipid droplets (HP:0006565)	3.38902688
13	Congenital, generalized hypertrichosis (HP:0004540)	3.36994227
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.26362954
15	Acute encephalopathy (HP:0006846)	3.25238655
16	Type II lissencephaly (HP:0007260)	3.22505874
17	Increased CSF lactate (HP:0002490)	3.15889291
18	Medial flaring of the eyebrow (HP:0010747)	3.14740512
19	Methylmalonic acidemia (HP:0002912)	3.13084674
20	Congenital stationary night blindness (HP:0007642)	3.07564599
21	Cortical visual impairment (HP:0100704)	3.04931939
22	Progressive macrocephaly (HP:0004481)	3.03862872
23	Retinal dysplasia (HP:0007973)	2.92976021
24	Abnormal number of erythroid precursors (HP:0012131)	2.90469018
25	Broad-based gait (HP:0002136)	2.88931085
26	Lipid accumulation in hepatocytes (HP:0006561)	2.88460048
27	Abnormality of cells of the erythroid lineage (HP:0012130)	2.86392458
28	Sensory axonal neuropathy (HP:0003390)	2.82344885
29	Renal Fanconi syndrome (HP:0001994)	2.78470662
30	Macrocytic anemia (HP:0001972)	2.77287576
31	Hepatic necrosis (HP:0002605)	2.73704418
32	Paralysis (HP:0003470)	2.72242683
33	Exertional dyspnea (HP:0002875)	2.70815924
34	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.70183427
35	Abnormality of alanine metabolism (HP:0010916)	2.70183427
36	Hyperalaninemia (HP:0003348)	2.70183427
37	Increased serum lactate (HP:0002151)	2.69346656
38	Aplastic anemia (HP:0001915)	2.68453520
39	Reticulocytopenia (HP:0001896)	2.63820876
40	Pancreatic fibrosis (HP:0100732)	2.60779950
41	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.57416910
42	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.49648357
43	Elevated erythrocyte sedimentation rate (HP:0003565)	2.47999292
44	Methylmalonic aciduria (HP:0012120)	2.40904859
45	Hemiparesis (HP:0001269)	2.36667883
46	Gait imbalance (HP:0002141)	2.35899992
47	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.32704776
48	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.32704776
49	Premature ovarian failure (HP:0008209)	2.32461269
50	Congenital primary aphakia (HP:0007707)	2.31566521
51	Microvesicular hepatic steatosis (HP:0001414)	2.31201631
52	Abnormal number of incisors (HP:0011064)	2.27739988
53	Median cleft lip (HP:0000161)	2.16613365
54	Confusion (HP:0001289)	2.16106804
55	Abnormality of the hip-girdle musculature (HP:0001445)	2.14388123
56	Abnormality of the musculature of the pelvis (HP:0001469)	2.14388123
57	Bile duct proliferation (HP:0001408)	2.10594136
58	Abnormal biliary tract physiology (HP:0012439)	2.10594136
59	Abnormality of the 2nd finger (HP:0004100)	2.10298885
60	True hermaphroditism (HP:0010459)	2.07942626
61	Absent eyelashes (HP:0000561)	2.07469348
62	Nephrogenic diabetes insipidus (HP:0009806)	2.05881635
63	Lactic acidosis (HP:0003128)	2.04972449
64	Respiratory difficulties (HP:0002880)	2.04196709
65	Pancreatic cysts (HP:0001737)	2.04153275
66	Adactyly (HP:0009776)	2.02248901
67	Increased intramyocellular lipid droplets (HP:0012240)	2.00265273
68	Impulsivity (HP:0100710)	2.00252588
69	Genital tract atresia (HP:0001827)	1.99434196
70	Dyschromatopsia (HP:0007641)	1.99291138
71	Microretrognathia (HP:0000308)	1.99265601
72	Synostosis involving the elbow (HP:0003938)	1.98195442
73	Humeroradial synostosis (HP:0003041)	1.98195442
74	Optic disc pallor (HP:0000543)	1.97010578
75	Hypoplasia of the radius (HP:0002984)	1.93314815
76	Abnormality of the nasal septum (HP:0000419)	1.92372236
77	Rib fusion (HP:0000902)	1.91546234
78	Reduced antithrombin III activity (HP:0001976)	1.90944132
79	Limb-girdle muscle atrophy (HP:0003797)	1.90762929
80	Cerebral edema (HP:0002181)	1.88157011
81	Molar tooth sign on MRI (HP:0002419)	1.88075955
82	Abnormality of midbrain morphology (HP:0002418)	1.88075955
83	Respiratory failure (HP:0002878)	1.87975097
84	Porencephaly (HP:0002132)	1.86073405
85	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.85950884
86	Lissencephaly (HP:0001339)	1.85825163
87	Oligodontia (HP:0000677)	1.85176833
88	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.82351981
89	Fibular aplasia (HP:0002990)	1.81436936
90	Sclerocornea (HP:0000647)	1.78975386
91	Hypergonadotropic hypogonadism (HP:0000815)	1.76892390
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.76241555
93	Absent/shortened dynein arms (HP:0200106)	1.76241555
94	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.74155052
95	Bulbous nose (HP:0000414)	1.74046846
96	Vaginal atresia (HP:0000148)	1.73007471
97	Partial duplication of the phalanx of hand (HP:0009999)	1.71758165
98	Ectopic kidney (HP:0000086)	1.70588374
99	Forearm undergrowth (HP:0009821)	1.70561041
100	Nephronophthisis (HP:0000090)	1.70121130

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	4.68300050
2	VRK2	4.34731639
3	STK16	4.01443526
4	MAPK15	3.40603650
5	NUAK1	3.03618031
6	VRK1	2.96356454
7	MST4	2.92396949
8	MAP3K4	2.56244996
9	MAP2K7	2.53774312
10	TIE1	2.44993968
11	TAF1	2.36791336
12	EPHA3	2.15696535
13	CCNB1	2.10529299
14	EIF2AK3	2.08712078
15	BCKDK	1.86661633
16	OXSR1	1.66393780
17	DYRK2	1.60297524
18	MARK1	1.52651202
19	TLK1	1.41051973
20	AKT3	1.38640207
21	EPHB2	1.38596000
22	GRK1	1.35169970
23	TNIK	1.34416158
24	CDK19	1.33773615
25	RPS6KA5	1.33634303
26	STK39	1.32611606
27	PNCK	1.20073267
28	DYRK3	1.09200043
29	ZAK	1.08599034
30	NME2	1.08154831
31	PIK3CA	1.05847335
32	GRK5	1.05270463
33	IRAK1	1.03114618
34	INSRR	1.02242552
35	MAPK13	1.01666925
36	DAPK2	1.00737791
37	TESK2	0.99987305
38	NME1	0.95717514
39	SGK2	0.93039495
40	PKN1	0.89756815
41	ABL2	0.88581511
42	WNK3	0.87379444
43	ADRBK2	0.83817134
44	EIF2AK1	0.82800551
45	SGK223	0.82347381
46	SGK494	0.82347381
47	FRK	0.82005975
48	TAOK3	0.80198743
49	SIK2	0.78043764
50	EIF2AK2	0.78018550
51	ILK	0.77723278
52	TGFBR2	0.75725992
53	DAPK3	0.73012771
54	TEC	0.69690306
55	TAOK1	0.67673839
56	PLK3	0.66945758
57	EPHA4	0.64194252
58	DMPK	0.63507792
59	CDK3	0.61768759
60	SRPK1	0.61209281
61	PRKCG	0.60657332
62	TXK	0.60000123
63	GRK7	0.59631785
64	CAMK4	0.58704793
65	PASK	0.56923692
66	KDR	0.56628135
67	MAP2K4	0.55365114
68	BRD4	0.51129498
69	PIM1	0.50937370
70	STK11	0.49230231
71	NLK	0.48553025
72	CHEK2	0.48188478
73	MAP4K2	0.46942268
74	AURKB	0.45645696
75	PRKCD	0.45573573
76	FLT3	0.45517379
77	BMPR1B	0.45122989
78	RAF1	0.44831057
79	ADRBK1	0.44657990
80	MAP4K1	0.44525541
81	PBK	0.43449480
82	FGR	0.43290873
83	ATR	0.42747582
84	NTRK2	0.42053296
85	AURKA	0.41319812
86	CAMK1	0.40215677
87	BRAF	0.38414321
88	CHUK	0.38311938
89	MAP3K3	0.34478369
90	CDC7	0.31803973
91	PRKACA	0.31305794
92	PRKCQ	0.31078792
93	SGK3	0.30702020
94	DYRK1B	0.29911772
95	MATK	0.29841926
96	IKBKB	0.29548443
97	RPS6KA1	0.28922133
98	ARAF	0.28064167
99	LATS1	0.27516058
100	CSNK2A1	0.27257182

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.33041387
2	Caffeine metabolism_Homo sapiens_hsa00232	4.87962718
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.59830732
4	Parkinsons disease_Homo sapiens_hsa05012	2.80569906
5	Protein export_Homo sapiens_hsa03060	2.39818277
6	Huntingtons disease_Homo sapiens_hsa05016	2.35781284
7	RNA polymerase_Homo sapiens_hsa03020	2.24491347
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.20003179
9	Alzheimers disease_Homo sapiens_hsa05010	2.07423426
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.04493110
11	Proteasome_Homo sapiens_hsa03050	2.01792503
12	Homologous recombination_Homo sapiens_hsa03440	1.95941946
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.87555191
14	Basal transcription factors_Homo sapiens_hsa03022	1.77874341
15	Spliceosome_Homo sapiens_hsa03040	1.76776578
16	RNA degradation_Homo sapiens_hsa03018	1.60260402
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.59484424
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.58188193
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48642435
20	Phototransduction_Homo sapiens_hsa04744	1.47513184
21	Chemical carcinogenesis_Homo sapiens_hsa05204	1.43280793
22	Olfactory transduction_Homo sapiens_hsa04740	1.43126935
23	DNA replication_Homo sapiens_hsa03030	1.35808304
24	Mismatch repair_Homo sapiens_hsa03430	1.35320172
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33884145
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.32278363
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.30422422
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.25567972
29	Purine metabolism_Homo sapiens_hsa00230	1.23489267
30	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.22440536
31	Propanoate metabolism_Homo sapiens_hsa00640	1.22077350
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.20037197
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.18753182
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.17775693
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.15314586
36	Regulation of autophagy_Homo sapiens_hsa04140	1.14303993
37	Antigen processing and presentation_Homo sapiens_hsa04612	1.12878254
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12187309
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.11958661
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.11304716
41	Asthma_Homo sapiens_hsa05310	1.06462927
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02945135
43	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.02927307
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01827249
45	Retinol metabolism_Homo sapiens_hsa00830	0.97980152
46	RNA transport_Homo sapiens_hsa03013	0.96887217
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96070187
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.92356488
49	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.91608740
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87378776
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.85855215
52	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.82216724
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.77957403
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76919516
55	Nicotine addiction_Homo sapiens_hsa05033	0.72242265
56	Metabolic pathways_Homo sapiens_hsa01100	0.65205859
57	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.64319619
58	African trypanosomiasis_Homo sapiens_hsa05143	0.63465858
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63010636
60	Graft-versus-host disease_Homo sapiens_hsa05332	0.61117575
61	One carbon pool by folate_Homo sapiens_hsa00670	0.60586518
62	Ether lipid metabolism_Homo sapiens_hsa00565	0.60359983
63	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.57851225
64	Non-homologous end-joining_Homo sapiens_hsa03450	0.57004304
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51687789
66	Peroxisome_Homo sapiens_hsa04146	0.50654391
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.48872140
68	Primary immunodeficiency_Homo sapiens_hsa05340	0.48225883
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.44909716
70	Base excision repair_Homo sapiens_hsa03410	0.44252171
71	Allograft rejection_Homo sapiens_hsa05330	0.43841964
72	Wnt signaling pathway_Homo sapiens_hsa04310	0.43309908
73	Insulin secretion_Homo sapiens_hsa04911	0.40490480
74	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39923708
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39458777
76	Herpes simplex infection_Homo sapiens_hsa05168	0.39402751
77	Rheumatoid arthritis_Homo sapiens_hsa05323	0.38259374
78	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.37230346
79	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36404707
80	ABC transporters_Homo sapiens_hsa02010	0.35897630
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.33546333
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.29686403
83	Glutathione metabolism_Homo sapiens_hsa00480	0.26460032
84	Alcoholism_Homo sapiens_hsa05034	0.25368546
85	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.24275739
86	Cocaine addiction_Homo sapiens_hsa05030	0.24090152
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.21318472
88	Salivary secretion_Homo sapiens_hsa04970	0.20668933
89	Legionellosis_Homo sapiens_hsa05134	0.19318620
90	Morphine addiction_Homo sapiens_hsa05032	0.18469531
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.18009014
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.17800883
93	Bile secretion_Homo sapiens_hsa04976	0.17726569
94	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.16848495
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.16596772
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.16292990
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.16091682
98	Type I diabetes mellitus_Homo sapiens_hsa04940	0.14049918
99	Circadian entrainment_Homo sapiens_hsa04713	0.13857297
100	Serotonergic synapse_Homo sapiens_hsa04726	0.12943898

SERBP1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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