ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	7.29157055
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.42205034
3	cytidine deamination (GO:0009972)	5.98725398
4	cytidine metabolic process (GO:0046087)	5.98725398
5	cytidine catabolic process (GO:0006216)	5.98725398
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.06411026
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.92098257
8	negative regulation by host of viral transcription (GO:0043922)	4.77764546
9	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	4.39262189
10	rRNA catabolic process (GO:0016075)	4.31326500
11	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.02751184
12	ncRNA catabolic process (GO:0034661)	4.01794390
13	7-methylguanosine mRNA capping (GO:0006370)	3.86085439
14	apoptotic DNA fragmentation (GO:0006309)	3.82904412
15	pseudouridine synthesis (GO:0001522)	3.82488889
16	proteasome assembly (GO:0043248)	3.81302795
17	microtubule depolymerization (GO:0007019)	3.81128643
18	L-fucose catabolic process (GO:0042355)	3.75672069
19	fucose catabolic process (GO:0019317)	3.75672069
20	L-fucose metabolic process (GO:0042354)	3.75672069
21	7-methylguanosine RNA capping (GO:0009452)	3.75437226
22	RNA capping (GO:0036260)	3.75437226
23	DNA damage response, detection of DNA damage (GO:0042769)	3.70545363
24	sulfate transport (GO:0008272)	3.62175179
25	positive regulation of muscle cell apoptotic process (GO:0010661)	3.56705696
26	cytokinetic process (GO:0032506)	3.51075742
27	replication fork processing (GO:0031297)	3.50872230
28	mitotic metaphase plate congression (GO:0007080)	3.47009630
29	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.42841169
30	organelle disassembly (GO:1903008)	3.41804969
31	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.34779160
32	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.33349728
33	chaperone-mediated protein transport (GO:0072321)	3.31805427
34	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.31264507
35	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.29040121
36	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.27034500
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.26094383
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.26094383
39	NADH dehydrogenase complex assembly (GO:0010257)	3.26094383
40	response to xenobiotic stimulus (GO:0009410)	3.23481412
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.23209541
42	ribonucleoprotein complex disassembly (GO:0032988)	3.22977190
43	termination of RNA polymerase III transcription (GO:0006386)	3.20761410
44	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.20761410
45	ATP synthesis coupled proton transport (GO:0015986)	3.16884957
46	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.16884957
47	protein complex biogenesis (GO:0070271)	3.15203471
48	spliceosomal snRNP assembly (GO:0000387)	3.06718285
49	formation of translation preinitiation complex (GO:0001731)	3.05855764
50	CENP-A containing nucleosome assembly (GO:0034080)	3.04050390
51	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.99110336
52	centriole replication (GO:0007099)	2.98987818
53	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.98334140
54	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.98214393
55	DNA ligation (GO:0006266)	2.97803946
56	chromatin remodeling at centromere (GO:0031055)	2.96435316
57	IMP biosynthetic process (GO:0006188)	2.96041513
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.89827970
59	G-protein coupled receptor internalization (GO:0002031)	2.88093265
60	termination of RNA polymerase I transcription (GO:0006363)	2.87674361
61	maturation of SSU-rRNA (GO:0030490)	2.87014750
62	DNA replication checkpoint (GO:0000076)	2.86233666
63	histone mRNA metabolic process (GO:0008334)	2.84738802
64	protein localization to kinetochore (GO:0034501)	2.84446087
65	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.82181522
66	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.82181522
67	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.82181522
68	transcription from RNA polymerase I promoter (GO:0006360)	2.81853379
69	respiratory chain complex IV assembly (GO:0008535)	2.78859386
70	modulation by host of symbiont transcription (GO:0052472)	2.77982884
71	modulation by host of viral transcription (GO:0043921)	2.77982884
72	rRNA metabolic process (GO:0016072)	2.76591362
73	cellular ketone body metabolic process (GO:0046950)	2.75620119
74	purine nucleobase biosynthetic process (GO:0009113)	2.75614718
75	ribosomal small subunit assembly (GO:0000028)	2.75256809
76	histone exchange (GO:0043486)	2.74283914
77	nucleotide-excision repair, DNA damage removal (GO:0000718)	2.73749418
78	DNA excision (GO:0044349)	2.73749418
79	IMP metabolic process (GO:0046040)	2.73566416
80	positive regulation of DNA-templated transcription, elongation (GO:0032786)	2.73464769
81	rRNA processing (GO:0006364)	2.73430882
82	behavioral response to nicotine (GO:0035095)	2.71816747
83	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	2.71142786
84	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.70004154
85	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.69492421
86	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.69195941
87	nucleobase biosynthetic process (GO:0046112)	2.68524962
88	electron transport chain (GO:0022900)	2.68371933
89	cytochrome complex assembly (GO:0017004)	2.66831944
90	respiratory electron transport chain (GO:0022904)	2.66500105
91	regulation of cofactor metabolic process (GO:0051193)	2.66070820
92	regulation of coenzyme metabolic process (GO:0051196)	2.66070820
93	regulation of sulfur metabolic process (GO:0042762)	2.64813300
94	ribosome assembly (GO:0042255)	2.63523202
95	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.63242783
96	platelet dense granule organization (GO:0060155)	2.63200130
97	N-terminal protein amino acid acetylation (GO:0006474)	2.63143473
98	positive regulation of defense response to virus by host (GO:0002230)	2.61945818
99	regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)	2.60561213
100	attachment of spindle microtubules to kinetochore (GO:0008608)	2.59568770

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.68630885
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.98828670
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.69372680
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.45113565
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.32131794
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17155193
7	VDR_22108803_ChIP-Seq_LS180_Human	3.04253886
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.99243301
9	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.98874453
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.77586623
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.66812857
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.65766471
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.54465657
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.46445468
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.45581231
16	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.37472052
17	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.35084838
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.34264209
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.31483310
20	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.28151349
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.20774392
22	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.06755589
23	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.06420049
24	EWS_26573619_Chip-Seq_HEK293_Human	1.96758316
25	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.95942163
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94175964
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.91384667
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.89513089
29	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.85869009
30	E2F7_22180533_ChIP-Seq_HELA_Human	1.85305564
31	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.77869428
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.74795919
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.69341931
34	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.67622861
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.67139214
36	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.63857639
37	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62869471
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.62503531
39	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.60372019
40	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60032251
41	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.57412306
42	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53926634
43	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.50411809
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50062464
45	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.46305515
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.42028326
47	IGF1R_20145208_ChIP-Seq_DFB_Human	1.37208172
48	FUS_26573619_Chip-Seq_HEK293_Human	1.36163182
49	GABP_19822575_ChIP-Seq_HepG2_Human	1.35761650
50	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.34230993
51	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32364627
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.29969622
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.29969622
54	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.26228081
55	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.25286110
56	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.24215849
57	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.22167404
58	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.22161972
59	DCP1A_22483619_ChIP-Seq_HELA_Human	1.21792817
60	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.21445333
61	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.21323175
62	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.19772184
63	XRN2_22483619_ChIP-Seq_HELA_Human	1.18856462
64	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.17548644
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14875463
66	P300_19829295_ChIP-Seq_ESCs_Human	1.14581757
67	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.14348324
68	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.09907037
69	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.09487051
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08459404
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08459404
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08079811
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08079811
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06037926
75	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.05986646
76	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.03575927
77	TP53_22573176_ChIP-Seq_HFKS_Human	1.02959787
78	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.02486251
79	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.02286341
80	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.00203655
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.98209200
82	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.97603559
83	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.97195965
84	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97117713
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.97069069
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97069069
87	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.95988129
88	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95225769
89	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.94385161
90	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.93695924
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92616377
92	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.92208545
93	CIITA_25753668_ChIP-Seq_RAJI_Human	0.91030731
94	ER_23166858_ChIP-Seq_MCF-7_Human	0.89975623
95	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.89356598
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.88926643
97	HTT_18923047_ChIP-ChIP_STHdh_Human	0.87624534
98	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.87362625
99	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.86446970
100	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.85315427

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001188_hyperpigmentation	4.02071695
2	MP0006292_abnormal_olfactory_placode	3.32736188
3	MP0009379_abnormal_foot_pigmentation	3.32327286
4	MP0009697_abnormal_copulation	3.22831042
5	MP0002163_abnormal_gland_morphology	2.96410952
6	MP0005174_abnormal_tail_pigmentation	2.44585625
7	MP0006072_abnormal_retinal_apoptosis	2.32941474
8	MP0004957_abnormal_blastocyst_morpholog	2.30032776
9	MP0008058_abnormal_DNA_repair	2.29568008
10	MP0008877_abnormal_DNA_methylation	2.25534219
11	MP0003136_yellow_coat_color	2.20595768
12	MP0001293_anophthalmia	2.14584303
13	MP0000569_abnormal_digit_pigmentation	2.13133820
14	MP0005377_hearing/vestibular/ear_phenot	2.08717649
15	MP0003878_abnormal_ear_physiology	2.08717649
16	MP0006035_abnormal_mitochondrial_morpho	2.00289102
17	MP0002736_abnormal_nociception_after	1.96639409
18	MP0010094_abnormal_chromosome_stability	1.96085983
19	MP0003646_muscle_fatigue	1.94774488
20	MP0005084_abnormal_gallbladder_morpholo	1.90027830
21	MP0003786_premature_aging	1.83758248
22	MP0005379_endocrine/exocrine_gland_phen	1.83387473
23	MP0003183_abnormal_peptide_metabolism	1.82720056
24	MP0001968_abnormal_touch/_nociception	1.81265301
25	MP0002837_dystrophic_cardiac_calcinosis	1.80918598
26	MP0003252_abnormal_bile_duct	1.77810903
27	MP0002102_abnormal_ear_morphology	1.75099048
28	MP0005671_abnormal_response_to	1.73742013
29	MP0003718_maternal_effect	1.70943052
30	MP0000372_irregular_coat_pigmentation	1.59014365
31	MP0003567_abnormal_fetal_cardiomyocyte	1.57008101
32	MP0004145_abnormal_muscle_electrophysio	1.55244544
33	MP0003806_abnormal_nucleotide_metabolis	1.54531615
34	MP0005645_abnormal_hypothalamus_physiol	1.46225734
35	MP0008875_abnormal_xenobiotic_pharmacok	1.44702715
36	MP0002938_white_spotting	1.44330013
37	MP0003111_abnormal_nucleus_morphology	1.43211902
38	MP0003890_abnormal_embryonic-extraembry	1.38747938
39	MP0004142_abnormal_muscle_tone	1.38076275
40	MP0003119_abnormal_digestive_system	1.37155609
41	MP0008872_abnormal_physiological_respon	1.36264891
42	MP0001529_abnormal_vocalization	1.30843237
43	MP0002254_reproductive_system_inflammat	1.30767062
44	MP0001835_abnormal_antigen_presentation	1.30599065
45	MP0003195_calcinosis	1.29820672
46	MP0002095_abnormal_skin_pigmentation	1.24435928
47	MP0005253_abnormal_eye_physiology	1.20545567
48	MP0008932_abnormal_embryonic_tissue	1.19667298
49	MP0004133_heterotaxia	1.19044064
50	MP0003787_abnormal_imprinting	1.18799092
51	MP0002277_abnormal_respiratory_mucosa	1.16943278
52	MP0002138_abnormal_hepatobiliary_system	1.14944960
53	MP0001919_abnormal_reproductive_system	1.13829334
54	MP0000015_abnormal_ear_pigmentation	1.12751430
55	MP0002006_tumorigenesis	1.09949303
56	MP0000631_abnormal_neuroendocrine_gland	1.06111543
57	MP0005551_abnormal_eye_electrophysiolog	1.05960632
58	MP0003693_abnormal_embryo_hatching	1.04641898
59	MP0000537_abnormal_urethra_morphology	1.04077524
60	MP0003077_abnormal_cell_cycle	1.03745093
61	MP0005187_abnormal_penis_morphology	1.01447364
62	MP0008961_abnormal_basal_metabolism	0.97225591
63	MP0005410_abnormal_fertilization	0.96713046
64	MP0003221_abnormal_cardiomyocyte_apopto	0.95545395
65	MP0006036_abnormal_mitochondrial_physio	0.95400985
66	MP0005075_abnormal_melanosome_morpholog	0.93458340
67	MP0001485_abnormal_pinna_reflex	0.93002513
68	MP0003763_abnormal_thymus_physiology	0.91707714
69	MP0002166_altered_tumor_susceptibility	0.91165485
70	MP0005389_reproductive_system_phenotype	0.90087659
71	MP0004215_abnormal_myocardial_fiber	0.89487078
72	MP0001730_embryonic_growth_arrest	0.89267772
73	MP0001764_abnormal_homeostasis	0.86214057
74	MP0002396_abnormal_hematopoietic_system	0.85963555
75	MP0004147_increased_porphyrin_level	0.85942682
76	MP0001697_abnormal_embryo_size	0.84754125
77	MP0002090_abnormal_vision	0.83129780
78	MP0002160_abnormal_reproductive_system	0.81844081
79	MP0003315_abnormal_perineum_morphology	0.81000537
80	MP0006054_spinal_hemorrhage	0.80372338
81	MP0000647_abnormal_sebaceous_gland	0.79643648
82	MP0000613_abnormal_salivary_gland	0.75213248
83	MP0008995_early_reproductive_senescence	0.74857095
84	MP0000358_abnormal_cell_content/	0.74336684
85	MP0004885_abnormal_endolymph	0.74154173
86	MP0002210_abnormal_sex_determination	0.73451710
87	MP0001879_abnormal_lymphatic_vessel	0.73131943
88	MP0005646_abnormal_pituitary_gland	0.72869291
89	MP0003186_abnormal_redox_activity	0.71804493
90	MP0005636_abnormal_mineral_homeostasis	0.71189699
91	MP0006276_abnormal_autonomic_nervous	0.70740553
92	MP0003937_abnormal_limbs/digits/tail_de	0.67856093
93	MP0000703_abnormal_thymus_morphology	0.66880600
94	MP0004084_abnormal_cardiac_muscle	0.66245637
95	MP0001145_abnormal_male_reproductive	0.64974130
96	MP0001286_abnormal_eye_development	0.64704964
97	MP0004742_abnormal_vestibular_system	0.64600113
98	MP0000313_abnormal_cell_death	0.64425463
99	MP0002009_preneoplasia	0.63875145
100	MP0004924_abnormal_behavior	0.63395295

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	3.82018884
2	Progressive inability to walk (HP:0002505)	3.49815481
3	Acute necrotizing encephalopathy (HP:0006965)	3.42592849
4	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.23728429
5	Abnormality of DNA repair (HP:0003254)	3.23434591
6	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.14667052
7	Abnormality of alanine metabolism (HP:0010916)	3.14667052
8	Hyperalaninemia (HP:0003348)	3.14667052
9	Mitochondrial inheritance (HP:0001427)	3.09960373
10	Inability to walk (HP:0002540)	3.07547598
11	Increased CSF lactate (HP:0002490)	3.03221301
12	Sensory axonal neuropathy (HP:0003390)	3.01252762
13	Methylmalonic aciduria (HP:0012120)	3.00938188
14	Increased serum pyruvate (HP:0003542)	2.97890783
15	Confusion (HP:0001289)	2.92058420
16	Abnormality of the labia minora (HP:0012880)	2.89221093
17	Methylmalonic acidemia (HP:0002912)	2.83371433
18	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.80844695
19	Abnormal mitochondria in muscle tissue (HP:0008316)	2.78976122
20	Acute encephalopathy (HP:0006846)	2.72863926
21	Progressive macrocephaly (HP:0004481)	2.71618273
22	Increased hepatocellular lipid droplets (HP:0006565)	2.71524570
23	Abnormal number of erythroid precursors (HP:0012131)	2.67162766
24	Clumsiness (HP:0002312)	2.64773416
25	Severe combined immunodeficiency (HP:0004430)	2.61666702
26	Metaphyseal dysplasia (HP:0100255)	2.59060778
27	Increased serum lactate (HP:0002151)	2.57277901
28	IgG deficiency (HP:0004315)	2.54980582
29	Amyotrophic lateral sclerosis (HP:0007354)	2.52733985
30	Hyperglycinemia (HP:0002154)	2.49734347
31	Prominent metopic ridge (HP:0005487)	2.45023576
32	Congenital stationary night blindness (HP:0007642)	2.42558292
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.41303924
34	Birth length less than 3rd percentile (HP:0003561)	2.40750561
35	Combined immunodeficiency (HP:0005387)	2.34521470
36	Colon cancer (HP:0003003)	2.33908997
37	Hepatocellular necrosis (HP:0001404)	2.32807979
38	Lipid accumulation in hepatocytes (HP:0006561)	2.32471672
39	Diastasis recti (HP:0001540)	2.31017990
40	Abnormality of glycolysis (HP:0004366)	2.30035768
41	Cerebral edema (HP:0002181)	2.28682637
42	Entropion (HP:0000621)	2.26644160
43	Elevated erythrocyte sedimentation rate (HP:0003565)	2.21826784
44	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.21556671
45	Premature ovarian failure (HP:0008209)	2.17406310
46	Abnormality of serum amino acid levels (HP:0003112)	2.17271126
47	Progressive muscle weakness (HP:0003323)	2.16909581
48	Lactic acidosis (HP:0003128)	2.14842226
49	Lower limb hyperreflexia (HP:0002395)	2.13574642
50	Cleft eyelid (HP:0000625)	2.12384607
51	Molar tooth sign on MRI (HP:0002419)	2.10081222
52	Abnormality of midbrain morphology (HP:0002418)	2.10081222
53	Ragged-red muscle fibers (HP:0003200)	2.09404174
54	Hypoplasia of the uterus (HP:0000013)	2.08683922
55	Poikiloderma (HP:0001029)	2.06791384
56	Thyroiditis (HP:0100646)	2.06234050
57	Progressive external ophthalmoplegia (HP:0000590)	2.05864364
58	Abnormality of the metopic suture (HP:0005556)	2.04361848
59	Stenosis of the external auditory canal (HP:0000402)	2.03851940
60	Pendular nystagmus (HP:0012043)	2.03540366
61	Hepatic necrosis (HP:0002605)	2.00438844
62	Abnormality of magnesium homeostasis (HP:0004921)	1.99867563
63	Posterior subcapsular cataract (HP:0007787)	1.99047565
64	Lethargy (HP:0001254)	1.98243561
65	Optic disc pallor (HP:0000543)	1.94912267
66	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.93674796
67	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.93674796
68	Pancytopenia (HP:0001876)	1.93369356
69	Hypoproteinemia (HP:0003075)	1.92212833
70	Neonatal respiratory distress (HP:0002643)	1.91204340
71	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91202730
72	Patellar aplasia (HP:0006443)	1.90932742
73	Anomalous pulmonary venous return (HP:0010772)	1.85738705
74	Absent thumb (HP:0009777)	1.84943750
75	Brittle hair (HP:0002299)	1.83621313
76	Type II lissencephaly (HP:0007260)	1.81654979
77	Rib fusion (HP:0000902)	1.81207143
78	Cerebral hypomyelination (HP:0006808)	1.80998788
79	Hyperglycinuria (HP:0003108)	1.79069726
80	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77784865
81	Cutaneous melanoma (HP:0012056)	1.76820300
82	Aplasia/Hypoplasia of the patella (HP:0006498)	1.75024893
83	Abnormality of T cells (HP:0002843)	1.74805343
84	Chromsome breakage (HP:0040012)	1.72249453
85	True hermaphroditism (HP:0010459)	1.71304906
86	Hypomagnesemia (HP:0002917)	1.71141585
87	Abnormal rod and cone electroretinograms (HP:0008323)	1.70002564
88	Ketoacidosis (HP:0001993)	1.69889521
89	Macrocytic anemia (HP:0001972)	1.69447236
90	T lymphocytopenia (HP:0005403)	1.69148071
91	Long clavicles (HP:0000890)	1.68684107
92	Mesangial abnormality (HP:0001966)	1.67092632
93	Hypoalbuminemia (HP:0003073)	1.66238382
94	Abnormal albumin level (HP:0012116)	1.66238382
95	Chronic diarrhea (HP:0002028)	1.65022183
96	Homocystinuria (HP:0002156)	1.64451823
97	Abnormality of homocysteine metabolism (HP:0010919)	1.64451823
98	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.63718154
99	Hypoplasia of the thymus (HP:0000778)	1.63495269
100	Leukodystrophy (HP:0002415)	1.62875724

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	6.77152297
2	DYRK3	4.33455536
3	ZAK	3.62671690
4	STK16	3.46400261
5	TXK	2.83574950
6	VRK2	2.48994164
7	WNK4	2.41106292
8	NUAK1	2.41066469
9	VRK1	2.09371392
10	NEK1	2.08988218
11	TNIK	2.07804720
12	CDC7	1.91047369
13	MAP4K2	1.85640703
14	PLK3	1.68435147
15	BUB1	1.62034706
16	KDR	1.61672095
17	ADRBK2	1.54690361
18	TLK1	1.54315573
19	NLK	1.52109637
20	TSSK6	1.49758207
21	OXSR1	1.49653544
22	MAPKAPK3	1.44748135
23	TAF1	1.43767511
24	TTK	1.26409275
25	PNCK	1.24353427
26	WEE1	1.19997421
27	STK39	1.18053385
28	PLK1	1.17148923
29	WNK3	1.11451561
30	RPS6KA4	1.09328538
31	ALK	1.05837429
32	DYRK2	1.03610152
33	SRPK1	1.02771789
34	PDK2	0.99630667
35	GRK1	0.93416747
36	CLK1	0.93280575
37	PLK4	0.91940157
38	MKNK2	0.90897216
39	AKT2	0.90397186
40	AKT3	0.89661866
41	TAOK3	0.88522315
42	ATR	0.85946254
43	PASK	0.84431189
44	CCNB1	0.83209185
45	RPS6KB2	0.80242996
46	CDK19	0.79066713
47	BRSK2	0.78484446
48	STK10	0.78015899
49	AURKB	0.76999585
50	EIF2AK3	0.76995378
51	MAP3K3	0.76018889
52	RPS6KA5	0.75445307
53	CHEK1	0.75079529
54	PINK1	0.73906714
55	TRIM28	0.69614296
56	MAPK13	0.69111331
57	MKNK1	0.68072195
58	PRKCQ	0.65423052
59	STK38L	0.65174664
60	BMPR2	0.61410413
61	ITK	0.61241884
62	INSRR	0.59954925
63	EEF2K	0.59664714
64	FRK	0.59556559
65	AURKA	0.53574545
66	ABL2	0.51288049
67	PBK	0.50733660
68	MUSK	0.50156075
69	BCKDK	0.49620292
70	PRKCI	0.47125677
71	IKBKB	0.44720788
72	OBSCN	0.43710650
73	CSNK2A1	0.42495563
74	ATM	0.42136758
75	MAP4K1	0.41522797
76	MAPK14	0.41419187
77	CHEK2	0.39611551
78	CSNK2A2	0.38763695
79	PRKCE	0.37891901
80	MAPKAPK5	0.35756931
81	TIE1	0.34913070
82	PLK2	0.34755222
83	IRAK1	0.32857977
84	MAP3K8	0.32487546
85	PAK1	0.30410069
86	SGK2	0.30100474
87	CSF1R	0.29807865
88	HIPK2	0.29382389
89	NEK2	0.29340456
90	CSNK1A1	0.28693403
91	TRPM7	0.28419009
92	CDK1	0.28341165
93	CSNK1E	0.28321365
94	MAP2K2	0.27695916
95	CDK2	0.26033275
96	WNK1	0.25563837
97	LIMK1	0.25474861
98	MAP3K14	0.25349106
99	SGK494	0.24282652
100	SGK223	0.24282652

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.33389387
2	Proteasome_Homo sapiens_hsa03050	3.27764455
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.77363277
4	Basal transcription factors_Homo sapiens_hsa03022	2.77151555
5	RNA polymerase_Homo sapiens_hsa03020	2.70649687
6	Antigen processing and presentation_Homo sapiens_hsa04612	2.58594170
7	Parkinsons disease_Homo sapiens_hsa05012	2.50503377
8	One carbon pool by folate_Homo sapiens_hsa00670	2.45276768
9	Protein export_Homo sapiens_hsa03060	2.31893767
10	Ribosome_Homo sapiens_hsa03010	2.17267716
11	RNA degradation_Homo sapiens_hsa03018	2.13622063
12	Homologous recombination_Homo sapiens_hsa03440	2.12101155
13	Nucleotide excision repair_Homo sapiens_hsa03420	1.94556686
14	RNA transport_Homo sapiens_hsa03013	1.91400967
15	Huntingtons disease_Homo sapiens_hsa05016	1.89547020
16	DNA replication_Homo sapiens_hsa03030	1.89338079
17	Asthma_Homo sapiens_hsa05310	1.85238454
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.82212447
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.80126187
20	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.79894869
21	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.79791589
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.74516366
23	Primary immunodeficiency_Homo sapiens_hsa05340	1.73462154
24	Spliceosome_Homo sapiens_hsa03040	1.69532367
25	Propanoate metabolism_Homo sapiens_hsa00640	1.62419945
26	Graft-versus-host disease_Homo sapiens_hsa05332	1.60277145
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58800946
28	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.57512225
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.52962347
30	Allograft rejection_Homo sapiens_hsa05330	1.44764082
31	Alzheimers disease_Homo sapiens_hsa05010	1.44004503
32	Phototransduction_Homo sapiens_hsa04744	1.42645399
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.38158071
34	Mismatch repair_Homo sapiens_hsa03430	1.35205411
35	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.34635832
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31897483
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.28889190
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28432520
39	Type I diabetes mellitus_Homo sapiens_hsa04940	1.26982365
40	Olfactory transduction_Homo sapiens_hsa04740	1.26427083
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.24234753
42	Purine metabolism_Homo sapiens_hsa00230	1.19106663
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.19061212
44	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17290814
45	Regulation of autophagy_Homo sapiens_hsa04140	1.15593321
46	Pyruvate metabolism_Homo sapiens_hsa00620	1.12425659
47	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.06711075
48	Butanoate metabolism_Homo sapiens_hsa00650	1.04744578
49	Base excision repair_Homo sapiens_hsa03410	0.97447245
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.96391290
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93589730
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.92836132
53	Glutathione metabolism_Homo sapiens_hsa00480	0.92709187
54	Viral myocarditis_Homo sapiens_hsa05416	0.88682648
55	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.84873748
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.83493274
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83331135
58	Selenocompound metabolism_Homo sapiens_hsa00450	0.83087717
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.81125545
60	Rheumatoid arthritis_Homo sapiens_hsa05323	0.75413615
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75105853
62	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71637819
63	mRNA surveillance pathway_Homo sapiens_hsa03015	0.69664863
64	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.67135154
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66746406
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63962755
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.63887842
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62666355
69	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.61385089
70	p53 signaling pathway_Homo sapiens_hsa04115	0.59467163
71	Cell cycle_Homo sapiens_hsa04110	0.57191821
72	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56558633
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.55900434
74	Sulfur metabolism_Homo sapiens_hsa00920	0.53542973
75	Metabolic pathways_Homo sapiens_hsa01100	0.50687362
76	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.48888807
77	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.48036122
78	Alcoholism_Homo sapiens_hsa05034	0.45378646
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44595192
80	Tight junction_Homo sapiens_hsa04530	0.42165741
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41049757
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40307587
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39046728
84	Herpes simplex infection_Homo sapiens_hsa05168	0.38951868
85	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.38843410
86	Peroxisome_Homo sapiens_hsa04146	0.34145858
87	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.33921806
88	Morphine addiction_Homo sapiens_hsa05032	0.31256815
89	Tryptophan metabolism_Homo sapiens_hsa00380	0.29425122
90	Serotonergic synapse_Homo sapiens_hsa04726	0.27172972
91	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.27122033
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.26403979
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.22475207
94	Caffeine metabolism_Homo sapiens_hsa00232	0.21624220
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.18011895
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.12616712
97	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.10816724
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.10222299
99	Nicotine addiction_Homo sapiens_hsa05033	0.09992195
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.09146981

SERBP1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »