ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to nitrosative stress (GO:0051409)	6.97410227
2	regulation of skeletal muscle contraction (GO:0014819)	5.79237508
3	L-ascorbic acid metabolic process (GO:0019852)	5.71712094
4	actin-myosin filament sliding (GO:0033275)	5.11992785
5	muscle filament sliding (GO:0030049)	5.11992785
6	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	4.75245619
7	viral mRNA export from host cell nucleus (GO:0046784)	4.72720879
8	cysteine metabolic process (GO:0006534)	4.69438920
9	seminiferous tubule development (GO:0072520)	4.65289632
10	regulation of mitochondrial translation (GO:0070129)	4.60560902
11	proteasome assembly (GO:0043248)	4.47038668
12	response to xenobiotic stimulus (GO:0009410)	4.41398592
13	actin-mediated cell contraction (GO:0070252)	4.15710354
14	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.04352458
15	ribosome assembly (GO:0042255)	4.03797068
16	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	4.02341970
17	glutathione derivative biosynthetic process (GO:1901687)	4.00558154
18	glutathione derivative metabolic process (GO:1901685)	4.00558154
19	heparin biosynthetic process (GO:0030210)	3.92829411
20	heparin metabolic process (GO:0030202)	3.92829411
21	negative regulation of T cell differentiation in thymus (GO:0033085)	3.78465398
22	S-adenosylmethionine metabolic process (GO:0046500)	3.60681885
23	uronic acid metabolic process (GO:0006063)	3.60131553
24	glucuronate metabolic process (GO:0019585)	3.60131553
25	aldehyde catabolic process (GO:0046185)	3.58342562
26	definitive hemopoiesis (GO:0060216)	3.51647413
27	nucleotide salvage (GO:0043173)	3.51119066
28	regulation of cholesterol esterification (GO:0010872)	3.50756118
29	pseudouridine synthesis (GO:0001522)	3.45780848
30	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.42466457
31	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	3.41434682
32	male meiosis I (GO:0007141)	3.40251929
33	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.38343521
34	chaperone-mediated protein transport (GO:0072321)	3.36362720
35	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.33358076
36	UMP biosynthetic process (GO:0006222)	3.33358076
37	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.33358076
38	UMP metabolic process (GO:0046049)	3.33358076
39	response to gravity (GO:0009629)	3.32223022
40	regulation of sarcomere organization (GO:0060297)	3.27120325
41	response to muscle activity (GO:0014850)	3.25236447
42	xenobiotic catabolic process (GO:0042178)	3.19404411
43	high-density lipoprotein particle remodeling (GO:0034375)	3.18170413
44	purine nucleotide salvage (GO:0032261)	3.15878292
45	flavonoid metabolic process (GO:0009812)	3.14881460
46	intra-S DNA damage checkpoint (GO:0031573)	3.12890259
47	C21-steroid hormone metabolic process (GO:0008207)	3.11896637
48	meiosis I (GO:0007127)	3.04271153
49	C21-steroid hormone biosynthetic process (GO:0006700)	3.02985010
50	cellular ketone body metabolic process (GO:0046950)	3.00047802
51	blood coagulation, intrinsic pathway (GO:0007597)	2.98734956
52	biotin metabolic process (GO:0006768)	2.97865096
53	muscle atrophy (GO:0014889)	2.96365093
54	ATP synthesis coupled proton transport (GO:0015986)	2.94177028
55	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.94177028
56	oxidative phosphorylation (GO:0006119)	2.92347294
57	regulation of cellular amino acid metabolic process (GO:0006521)	2.90272415
58	muscle cell cellular homeostasis (GO:0046716)	2.87851209
59	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	2.87744927
60	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.86611964
61	reciprocal DNA recombination (GO:0035825)	2.84539836
62	reciprocal meiotic recombination (GO:0007131)	2.84539836
63	glyoxylate metabolic process (GO:0046487)	2.82095276
64	DNA deamination (GO:0045006)	2.81908846
65	positive regulation of T cell apoptotic process (GO:0070234)	2.81904912
66	skeletal muscle contraction (GO:0003009)	2.81172815
67	ketone body metabolic process (GO:1902224)	2.80652806
68	serine family amino acid metabolic process (GO:0009069)	2.79998002
69	actin filament-based movement (GO:0030048)	2.77463234
70	progesterone metabolic process (GO:0042448)	2.77383095
71	cellular glucuronidation (GO:0052695)	2.77348466
72	positive regulation of T cell differentiation in thymus (GO:0033089)	2.77100588
73	dicarboxylic acid biosynthetic process (GO:0043650)	2.75929327
74	single strand break repair (GO:0000012)	2.75546202
75	skeletal muscle tissue regeneration (GO:0043403)	2.73572331
76	water-soluble vitamin biosynthetic process (GO:0042364)	2.72764990
77	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.71988348
78	striated muscle atrophy (GO:0014891)	2.71475151
79	ribosomal large subunit biogenesis (GO:0042273)	2.71193911
80	skeletal muscle adaptation (GO:0043501)	2.70896045
81	positive regulation of Rho protein signal transduction (GO:0035025)	2.69679632
82	reverse cholesterol transport (GO:0043691)	2.69191969
83	branched-chain amino acid catabolic process (GO:0009083)	2.69180359
84	plasma membrane fusion (GO:0045026)	2.68183719
85	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.67627350
86	preassembly of GPI anchor in ER membrane (GO:0016254)	2.67472905
87	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.65763895
88	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.65763895
89	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.64594161
90	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.64594161
91	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.64594161
92	regulation of relaxation of muscle (GO:1901077)	2.63803372
93	regulation of thymocyte apoptotic process (GO:0070243)	2.61076841
94	neuronal action potential (GO:0019228)	2.60746190
95	positive regulation of histone H3-K4 methylation (GO:0051571)	2.60299490
96	glutamate metabolic process (GO:0006536)	2.59554493
97	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.59503350
98	isotype switching (GO:0045190)	2.59503350
99	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.59503350
100	rRNA modification (GO:0000154)	2.58158283

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.34385604
2	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.50425311
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.44015596
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.39824768
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.19757878
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.17973921
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.11812056
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.91472462
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84219633
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.78127801
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.76608454
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.75192239
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.71119391
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.66854962
15	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.57184800
16	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.47105870
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.29484281
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.26308417
19	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.21707514
20	VDR_22108803_ChIP-Seq_LS180_Human	2.17918148
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12111610
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.11443404
23	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.01059216
24	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.94364118
25	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.87190869
26	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.80544808
27	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.79802089
28	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.76071999
29	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.72425948
30	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.69313900
31	FUS_26573619_Chip-Seq_HEK293_Human	1.68699581
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.65503546
33	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.64293718
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.63262316
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.60086472
36	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55059683
37	E2F7_22180533_ChIP-Seq_HELA_Human	1.54868754
38	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.53647699
39	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.51848393
40	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.47587281
41	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.46709666
42	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.40992511
43	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.40843474
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.39427981
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.39390763
46	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.35333335
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.35249628
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34702220
49	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.34249762
50	ERG_20517297_ChIP-Seq_VCAP_Human	1.30679998
51	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.29753759
52	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.28832546
53	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28004420
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26762152
55	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26530652
56	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.24959252
57	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.23373499
58	DCP1A_22483619_ChIP-Seq_HELA_Human	1.23270207
59	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.21786868
60	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.21659066
61	XRN2_22483619_ChIP-Seq_HELA_Human	1.21241623
62	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20372607
63	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.19223807
64	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.16716238
65	TAF15_26573619_Chip-Seq_HEK293_Human	1.14969592
66	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.12669864
67	TTF2_22483619_ChIP-Seq_HELA_Human	1.11945936
68	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.11802000
69	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.11029431
70	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10076150
71	TP53_22573176_ChIP-Seq_HFKS_Human	1.09955003
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08829078
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08642704
74	HTT_18923047_ChIP-ChIP_STHdh_Human	1.08625995
75	CBP_21632823_ChIP-Seq_H3396_Human	1.07445296
76	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.06950968
77	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.06205310
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05524256
79	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.05140678
80	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.04803344
81	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.04218415
82	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02572236
83	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01250288
84	CBP_20019798_ChIP-Seq_JUKART_Human	1.00556703
85	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00556703
86	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.00139359
87	EWS_26573619_Chip-Seq_HEK293_Human	0.99493056
88	AR_20517297_ChIP-Seq_VCAP_Human	0.98647285
89	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.94811276
90	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.93616508
91	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.92345877
92	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.89534948
93	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.89184403
94	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.88761673
95	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.88650872
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.88017150
97	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.83649345
98	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.83044631
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.83044631
100	KDM5A_27292631_Chip-Seq_BREAST_Human	0.82905670

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.48833776
2	MP0000749_muscle_degeneration	3.84845047
3	MP0004145_abnormal_muscle_electrophysio	3.78811980
4	MP0002736_abnormal_nociception_after	3.71388905
5	MP0002269_muscular_atrophy	3.31992977
6	MP0000372_irregular_coat_pigmentation	3.10434817
7	MP0001986_abnormal_taste_sensitivity	2.89033007
8	MP0003950_abnormal_plasma_membrane	2.81729075
9	MP0000750_abnormal_muscle_regeneration	2.74491156
10	MP0008058_abnormal_DNA_repair	2.66482877
11	MP0004147_increased_porphyrin_level	2.59439302
12	MP0004036_abnormal_muscle_relaxation	2.59116355
13	MP0000747_muscle_weakness	2.47280686
14	MP0005670_abnormal_white_adipose	2.45573354
15	MP0009697_abnormal_copulation	2.42341624
16	MP0003646_muscle_fatigue	2.30339403
17	MP0001968_abnormal_touch/_nociception	2.27198409
18	MP0008057_abnormal_DNA_replication	2.17552356
19	MP0005423_abnormal_somatic_nervous	2.15552366
20	MP0000751_myopathy	2.01212569
21	MP0002106_abnormal_muscle_physiology	2.00567998
22	MP0000759_abnormal_skeletal_muscle	2.00398646
23	MP0002254_reproductive_system_inflammat	2.00128043
24	MP0002138_abnormal_hepatobiliary_system	1.93597207
25	MP0002139_abnormal_hepatobiliary_system	1.90137357
26	MP0006036_abnormal_mitochondrial_physio	1.78845140
27	MP0003718_maternal_effect	1.77608296
28	MP0002396_abnormal_hematopoietic_system	1.69874586
29	MP0003191_abnormal_cellular_cholesterol	1.66885674
30	MP0005085_abnormal_gallbladder_physiolo	1.63863096
31	MP0001727_abnormal_embryo_implantation	1.63596866
32	MP0010368_abnormal_lymphatic_system	1.54310157
33	MP0005408_hypopigmentation	1.53912827
34	MP0005369_muscle_phenotype	1.52593802
35	MP0006054_spinal_hemorrhage	1.52273380
36	MP0003890_abnormal_embryonic-extraembry	1.49803660
37	MP0004142_abnormal_muscle_tone	1.48527004
38	MP0004087_abnormal_muscle_fiber	1.47021805
39	MP0008875_abnormal_xenobiotic_pharmacok	1.44845963
40	MP0004084_abnormal_cardiac_muscle	1.44230534
41	MP0005645_abnormal_hypothalamus_physiol	1.43093644
42	MP0008877_abnormal_DNA_methylation	1.38965879
43	MP0004215_abnormal_myocardial_fiber	1.34469329
44	MP0000465_gastrointestinal_hemorrhage	1.33203991
45	MP0001764_abnormal_homeostasis	1.30873003
46	MP0005253_abnormal_eye_physiology	1.27471053
47	MP0003186_abnormal_redox_activity	1.27181201
48	MP0005620_abnormal_muscle_contractility	1.25967173
49	MP0003880_abnormal_central_pattern	1.24732273
50	MP0006035_abnormal_mitochondrial_morpho	1.23311760
51	MP0004233_abnormal_muscle_weight	1.16694783
52	MP0009840_abnormal_foam_cell	1.15602634
53	MP0008007_abnormal_cellular_replicative	1.15066844
54	MP0006276_abnormal_autonomic_nervous	1.14609022
55	MP0004484_altered_response_of	1.12823898
56	MP0010094_abnormal_chromosome_stability	1.12754816
57	MP0003252_abnormal_bile_duct	1.10208961
58	MP0002876_abnormal_thyroid_physiology	1.07680910
59	MP0005451_abnormal_body_composition	1.05070125
60	MP0005647_abnormal_sex_gland	0.99564649
61	MP0003868_abnormal_feces_composition	0.95116871
62	MP0003137_abnormal_impulse_conducting	0.93495927
63	MP0003786_premature_aging	0.92905205
64	MP0006072_abnormal_retinal_apoptosis	0.91298534
65	MP0002733_abnormal_thermal_nociception	0.90056609
66	MP0001119_abnormal_female_reproductive	0.89067231
67	MP0005330_cardiomyopathy	0.86100984
68	MP0004782_abnormal_surfactant_physiolog	0.82139100
69	MP0004134_abnormal_chest_morphology	0.80386814
70	MP0005464_abnormal_platelet_physiology	0.79840764
71	MP0005266_abnormal_metabolism	0.79573152
72	MP0002108_abnormal_muscle_morphology	0.78629625
73	MP0002160_abnormal_reproductive_system	0.78224925
74	MP0005551_abnormal_eye_electrophysiolog	0.76879865
75	MP0003221_abnormal_cardiomyocyte_apopto	0.75869912
76	MP0005365_abnormal_bile_salt	0.75765058
77	MP0004957_abnormal_blastocyst_morpholog	0.75238108
78	MP0001879_abnormal_lymphatic_vessel	0.68727588
79	MP0004808_abnormal_hematopoietic_stem	0.68727165
80	MP0008872_abnormal_physiological_respon	0.68343691
81	MP0005410_abnormal_fertilization	0.68304180
82	MP0003011_delayed_dark_adaptation	0.66979760
83	MP0002102_abnormal_ear_morphology	0.65396018
84	MP0002972_abnormal_cardiac_muscle	0.61936847
85	MP0008004_abnormal_stomach_pH	0.61590982
86	MP0005075_abnormal_melanosome_morpholog	0.60104181
87	MP0001835_abnormal_antigen_presentation	0.57114504
88	MP0001929_abnormal_gametogenesis	0.56962654
89	MP0010329_abnormal_lipoprotein_level	0.56506842
90	MP0002090_abnormal_vision	0.55819221
91	MP0005332_abnormal_amino_acid	0.55323280
92	MP0000462_abnormal_digestive_system	0.55302071
93	MP0001730_embryonic_growth_arrest	0.54576352
94	MP0001666_abnormal_nutrient_absorption	0.54298276
95	MP0002089_abnormal_postnatal_growth/wei	0.53365516
96	MP0000653_abnormal_sex_gland	0.52869248
97	MP0003699_abnormal_female_reproductive	0.52847924
98	MP0002067_abnormal_sensory_capabilities	0.52716372
99	MP0009115_abnormal_fat_cell	0.51130355
100	MP0001661_extended_life_span	0.50419348

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Nemaline bodies (HP:0003798)	5.18848389
2	Exercise-induced myalgia (HP:0003738)	4.98839844
3	Type 2 muscle fiber atrophy (HP:0003554)	4.90432561
4	Muscle hypertrophy of the lower extremities (HP:0008968)	4.50590609
5	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	4.43615710
6	Muscle fiber inclusion bodies (HP:0100299)	4.32035396
7	Exercise-induced muscle cramps (HP:0003710)	4.21030052
8	Spontaneous abortion (HP:0005268)	4.20797515
9	Muscle fiber atrophy (HP:0100295)	4.19923154
10	Distal arthrogryposis (HP:0005684)	3.89646168
11	Myotonia (HP:0002486)	3.67621192
12	Hepatocellular necrosis (HP:0001404)	3.66583593
13	Male infertility (HP:0003251)	3.48312627
14	Round ear (HP:0100830)	3.44512491
15	Amniotic constriction ring (HP:0009775)	3.42732258
16	Abnormality of placental membranes (HP:0011409)	3.42732258
17	Muscle stiffness (HP:0003552)	3.42315904
18	Calf muscle hypertrophy (HP:0008981)	3.39559887
19	Hepatic necrosis (HP:0002605)	3.32988591
20	Increased serum pyruvate (HP:0003542)	3.19850229
21	Mitochondrial inheritance (HP:0001427)	3.09517055
22	Hyperglycinemia (HP:0002154)	3.05093010
23	Increased CSF lactate (HP:0002490)	3.03299322
24	Aplastic anemia (HP:0001915)	3.02688160
25	Acute encephalopathy (HP:0006846)	3.00898565
26	Hyperglycinuria (HP:0003108)	3.00005087
27	Chronic hepatic failure (HP:0100626)	2.99227782
28	Fetal akinesia sequence (HP:0001989)	2.97566599
29	Abnormal pupillary function (HP:0007686)	2.96141225
30	Areflexia of lower limbs (HP:0002522)	2.89866838
31	Ulnar deviation of the wrist (HP:0003049)	2.89017395
32	Abnormal mitochondria in muscle tissue (HP:0008316)	2.87883155
33	Entropion (HP:0000621)	2.86097118
34	Intrahepatic cholestasis (HP:0001406)	2.85258260
35	Hypobetalipoproteinemia (HP:0003563)	2.76385172
36	Abnormality of glycolysis (HP:0004366)	2.76030033
37	Amyotrophic lateral sclerosis (HP:0007354)	2.73372447
38	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.66578101
39	Abnormality of alanine metabolism (HP:0010916)	2.66578101
40	Hyperalaninemia (HP:0003348)	2.66578101
41	Popliteal pterygium (HP:0009756)	2.66554198
42	Acute necrotizing encephalopathy (HP:0006965)	2.62083614
43	Absent phalangeal crease (HP:0006109)	2.61670875
44	Rhabdomyolysis (HP:0003201)	2.54902324
45	Sensory axonal neuropathy (HP:0003390)	2.51683252
46	Sudden death (HP:0001699)	2.47439667
47	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.45182951
48	Neck muscle weakness (HP:0000467)	2.45164253
49	Retinal dysplasia (HP:0007973)	2.44054869
50	Abnormality of serine family amino acid metabolism (HP:0010894)	2.43609504
51	Abnormality of glycine metabolism (HP:0010895)	2.43609504
52	Increased serum lactate (HP:0002151)	2.43427937
53	Type 1 muscle fiber predominance (HP:0003803)	2.43361514
54	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.39770918
55	Oral leukoplakia (HP:0002745)	2.39136470
56	Increased intramyocellular lipid droplets (HP:0012240)	2.38779120
57	Exercise intolerance (HP:0003546)	2.35849183
58	Abnormal finger flexion creases (HP:0006143)	2.32159019
59	Abnormality of the neuromuscular junction (HP:0003398)	2.29119263
60	Fatigable weakness (HP:0003473)	2.29119263
61	Fat malabsorption (HP:0002630)	2.28792173
62	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.28635425
63	Gowers sign (HP:0003391)	2.23543235
64	Steatorrhea (HP:0002570)	2.22666761
65	CNS demyelination (HP:0007305)	2.22499596
66	Progressive muscle weakness (HP:0003323)	2.21795549
67	Abnormality of the calf musculature (HP:0001430)	2.20032238
68	Calcaneovalgus deformity (HP:0001848)	2.17412063
69	Palpebral edema (HP:0100540)	2.17310606
70	Increased muscle lipid content (HP:0009058)	2.15690438
71	Weak cry (HP:0001612)	2.15075567
72	Broad alveolar ridges (HP:0000187)	2.12800368
73	Pancytopenia (HP:0001876)	2.12588645
74	Progressive macrocephaly (HP:0004481)	2.11894277
75	Poikiloderma (HP:0001029)	2.11366364
76	Lactic acidosis (HP:0003128)	2.09635540
77	Malignant hyperthermia (HP:0002047)	2.07985470
78	Deformed tarsal bones (HP:0008119)	2.05887247
79	Progressive inability to walk (HP:0002505)	2.05317443
80	Hypolipoproteinemia (HP:0010981)	2.04964657
81	Hyperkalemia (HP:0002153)	2.04566145
82	Ectropion (HP:0000656)	2.03615680
83	Gaze-evoked nystagmus (HP:0000640)	2.02996655
84	Lipid accumulation in hepatocytes (HP:0006561)	2.00165640
85	Metabolic acidosis (HP:0001942)	1.98983809
86	Increased hepatocellular lipid droplets (HP:0006565)	1.98830720
87	Myoglobinuria (HP:0002913)	1.98277297
88	Thyroid-stimulating hormone excess (HP:0002925)	1.95574823
89	Cerebral edema (HP:0002181)	1.94535770
90	Progressive external ophthalmoplegia (HP:0000590)	1.92295543
91	Short tibia (HP:0005736)	1.91942011
92	Ragged-red muscle fibers (HP:0003200)	1.91012197
93	Pigmentary retinal degeneration (HP:0001146)	1.90800475
94	Poor eye contact (HP:0000817)	1.86954020
95	Methylmalonic acidemia (HP:0002912)	1.85847876
96	Abnormality of the anterior horn cell (HP:0006802)	1.85093574
97	Degeneration of anterior horn cells (HP:0002398)	1.85093574
98	Hyperammonemia (HP:0001987)	1.84778837
99	Abnormality of serum amino acid levels (HP:0003112)	1.82601890
100	Respiratory failure (HP:0002878)	1.82472510

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	3.98556456
2	MST4	3.94118898
3	PDK2	3.92039054
4	PBK	3.87742252
5	PINK1	3.26269673
6	DYRK2	2.34534598
7	NME1	2.20574439
8	NUAK1	2.19337708
9	SRPK1	2.06018842
10	KDR	2.04643774
11	CSNK1A1L	2.03605157
12	TIE1	1.98448957
13	TAOK3	1.83162621
14	BCKDK	1.81464226
15	KIT	1.80270688
16	PIK3CG	1.77190640
17	ZAK	1.75158921
18	CSNK1G2	1.70014234
19	AKT3	1.69441832
20	LATS1	1.68719208
21	CSNK1G3	1.60181707
22	BMPR1B	1.60124547
23	EIF2AK3	1.47296349
24	CSF1R	1.46934912
25	MAP4K2	1.46706001
26	VRK1	1.42907821
27	VRK2	1.40318172
28	CCNB1	1.38937903
29	PHKG2	1.37286847
30	PHKG1	1.37286847
31	TESK2	1.36286415
32	CSNK1G1	1.33811257
33	LIMK1	1.30027318
34	CDK19	1.29776466
35	MAP4K1	1.19818018
36	FLT3	1.10357955
37	HIPK2	1.09588484
38	PLK2	1.04583166
39	DAPK1	1.04539178
40	EIF2AK1	1.03848336
41	RPS6KA4	1.01727808
42	OXSR1	1.00980391
43	TNIK	0.97553359
44	ABL2	0.94735393
45	AKT2	0.94078490
46	MAP2K7	0.93294362
47	PNCK	0.92011644
48	EPHA4	0.90140931
49	DYRK3	0.84370183
50	TEC	0.83490241
51	RPS6KA5	0.83481533
52	TRPM7	0.82940682
53	WNK3	0.79832807
54	NME2	0.77555699
55	MAP3K4	0.77150293
56	TSSK6	0.69539067
57	SCYL2	0.67938858
58	PAK4	0.66915716
59	PRKACB	0.64783089
60	CAMK2G	0.64399750
61	TAF1	0.64054108
62	CSNK2A2	0.61802485
63	MAP3K5	0.60983436
64	CHEK2	0.58864142
65	AURKA	0.58599984
66	CSNK1A1	0.56412192
67	FER	0.53837173
68	MYLK	0.51983571
69	CDK6	0.51956932
70	CAMK2D	0.51234984
71	CHUK	0.51072886
72	CSNK2A1	0.50295975
73	ITK	0.50158172
74	CSNK1D	0.49856865
75	INSRR	0.49229055
76	ATR	0.49063959
77	SYK	0.48145804
78	STK39	0.47583355
79	EIF2AK2	0.45813417
80	PLK3	0.45701215
81	MKNK1	0.44011944
82	MAP3K12	0.43010465
83	PIK3CA	0.42633061
84	PLK4	0.40161971
85	BLK	0.40118708
86	PLK1	0.40046558
87	MAPK13	0.39471775
88	IKBKB	0.39229829
89	PRKD1	0.38029522
90	CHEK1	0.37023781
91	NEK1	0.36849830
92	GRK5	0.36614879
93	GRK1	0.36560791
94	MAPK11	0.36021776
95	CDC7	0.35911535
96	CASK	0.35097829
97	ATM	0.33854312
98	CDK4	0.33219984
99	GSK3A	0.32942511
100	EGFR	0.31686928

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.62928616
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.92256654
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.85007516
4	Glutathione metabolism_Homo sapiens_hsa00480	2.65042336
5	Propanoate metabolism_Homo sapiens_hsa00640	2.39543234
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.34953130
7	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.28101144
8	Fatty acid elongation_Homo sapiens_hsa00062	2.13754346
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.11866671
10	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.09175004
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.06172868
12	Parkinsons disease_Homo sapiens_hsa05012	1.97661528
13	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.96144155
14	DNA replication_Homo sapiens_hsa03030	1.92822382
15	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.91442640
16	Chemical carcinogenesis_Homo sapiens_hsa05204	1.89898124
17	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.83539180
18	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.81350684
19	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.74249076
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.71973024
21	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.69846849
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.56326064
23	Butanoate metabolism_Homo sapiens_hsa00650	1.56289643
24	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.54253840
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.54154506
26	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.48804017
27	Protein export_Homo sapiens_hsa03060	1.45189983
28	Pyruvate metabolism_Homo sapiens_hsa00620	1.44709204
29	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.36843501
30	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.36196326
31	Alzheimers disease_Homo sapiens_hsa05010	1.35534968
32	Carbon metabolism_Homo sapiens_hsa01200	1.34516090
33	Peroxisome_Homo sapiens_hsa04146	1.33271204
34	Retinol metabolism_Homo sapiens_hsa00830	1.32920006
35	One carbon pool by folate_Homo sapiens_hsa00670	1.29141086
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.25511805
37	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.23960891
38	Cardiac muscle contraction_Homo sapiens_hsa04260	1.23518914
39	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.19782145
40	Arginine biosynthesis_Homo sapiens_hsa00220	1.17729948
41	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.17237433
42	Spliceosome_Homo sapiens_hsa03040	1.15064762
43	Non-homologous end-joining_Homo sapiens_hsa03450	1.14827469
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.14355358
45	Fatty acid degradation_Homo sapiens_hsa00071	1.14159194
46	Selenocompound metabolism_Homo sapiens_hsa00450	1.13915418
47	Huntingtons disease_Homo sapiens_hsa05016	1.12221365
48	RNA transport_Homo sapiens_hsa03013	1.11567976
49	Fat digestion and absorption_Homo sapiens_hsa04975	1.10920202
50	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09819423
51	RNA polymerase_Homo sapiens_hsa03020	1.09340604
52	Tryptophan metabolism_Homo sapiens_hsa00380	1.06584263
53	Caffeine metabolism_Homo sapiens_hsa00232	1.01113243
54	RNA degradation_Homo sapiens_hsa03018	1.00485047
55	Purine metabolism_Homo sapiens_hsa00230	1.00200338
56	Primary immunodeficiency_Homo sapiens_hsa05340	0.99814107
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.98507001
58	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.90912767
59	Regulation of autophagy_Homo sapiens_hsa04140	0.89816340
60	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87973978
61	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.85295790
62	Asthma_Homo sapiens_hsa05310	0.84335723
63	Base excision repair_Homo sapiens_hsa03410	0.83945147
64	Mismatch repair_Homo sapiens_hsa03430	0.81767479
65	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.81655690
66	Linoleic acid metabolism_Homo sapiens_hsa00591	0.79624117
67	Ribosome_Homo sapiens_hsa03010	0.79302609
68	Metabolic pathways_Homo sapiens_hsa01100	0.78899394
69	Olfactory transduction_Homo sapiens_hsa04740	0.78624099
70	Complement and coagulation cascades_Homo sapiens_hsa04610	0.78403091
71	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.73639349
72	Basal transcription factors_Homo sapiens_hsa03022	0.70385061
73	Tight junction_Homo sapiens_hsa04530	0.67246373
74	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.62358215
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.55597586
76	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55421034
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.53885675
78	Phenylalanine metabolism_Homo sapiens_hsa00360	0.53225211
79	Fanconi anemia pathway_Homo sapiens_hsa03460	0.52396376
80	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51839857
81	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49686413
82	Viral myocarditis_Homo sapiens_hsa05416	0.48459843
83	Homologous recombination_Homo sapiens_hsa03440	0.46295250
84	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.44197423
85	Phototransduction_Homo sapiens_hsa04744	0.43512735
86	Alcoholism_Homo sapiens_hsa05034	0.42342590
87	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.42261746
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.42109112
89	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40865462
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.40751142
91	PPAR signaling pathway_Homo sapiens_hsa03320	0.40426675
92	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37770485
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35522843
94	ABC transporters_Homo sapiens_hsa02010	0.35133262
95	Taste transduction_Homo sapiens_hsa04742	0.34061473
96	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.33059860
97	Legionellosis_Homo sapiens_hsa05134	0.32266282
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.30097421
99	Circadian rhythm_Homo sapiens_hsa04710	0.27265233
100	Galactose metabolism_Homo sapiens_hsa00052	0.26659612

SERBP1P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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