SERGEF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.19944448
2neuron cell-cell adhesion (GO:0007158)4.93610065
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.65115541
4vocalization behavior (GO:0071625)4.59551537
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.48898935
6protein localization to synapse (GO:0035418)4.48499571
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.44637800
8positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.23196985
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18565313
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.18224842
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17821008
12ATP synthesis coupled proton transport (GO:0015986)4.17821008
13locomotory exploration behavior (GO:0035641)4.11166203
14negative regulation of microtubule polymerization (GO:0031115)4.09683066
15regulation of glutamate receptor signaling pathway (GO:1900449)4.09190255
16gamma-aminobutyric acid signaling pathway (GO:0007214)4.08910739
17chaperone-mediated protein transport (GO:0072321)4.03708882
18glutamate secretion (GO:0014047)3.97174395
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.89006572
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.87749720
21neurotransmitter secretion (GO:0007269)3.86841898
22energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.84774336
23ATP hydrolysis coupled proton transport (GO:0015991)3.84774336
24exploration behavior (GO:0035640)3.76929076
25synaptic transmission, glutamatergic (GO:0035249)3.67358965
26glutamate receptor signaling pathway (GO:0007215)3.66575427
27regulation of synaptic vesicle exocytosis (GO:2000300)3.65466791
28postsynaptic membrane organization (GO:0001941)3.60968435
29neuron-neuron synaptic transmission (GO:0007270)3.56179792
30positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.52045538
31positive regulation of neurotransmitter secretion (GO:0001956)3.51763185
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.47950203
33transferrin transport (GO:0033572)3.42883005
34regulation of synaptic vesicle transport (GO:1902803)3.40511555
35opioid receptor signaling pathway (GO:0038003)3.40475593
36neuronal action potential propagation (GO:0019227)3.39396031
37protein neddylation (GO:0045116)3.35952875
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32478818
39positive regulation of neurotransmitter transport (GO:0051590)3.31794797
40positive regulation of membrane potential (GO:0045838)3.31533765
41regulation of synapse structural plasticity (GO:0051823)3.29157199
42neuron recognition (GO:0008038)3.28298462
43regulation of glutamate secretion (GO:0014048)3.28243284
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26365122
45synaptic vesicle maturation (GO:0016188)3.21023468
46protein polyglutamylation (GO:0018095)3.20754116
47G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16910501
48trivalent inorganic cation transport (GO:0072512)3.16152409
49ferric iron transport (GO:0015682)3.16152409
50neurotransmitter transport (GO:0006836)3.14872680
51behavioral response to nicotine (GO:0035095)3.13941364
52presynaptic membrane assembly (GO:0097105)3.10960436
53respiratory electron transport chain (GO:0022904)3.10725369
54positive regulation of synapse maturation (GO:0090129)3.09426432
55serotonin metabolic process (GO:0042428)3.08882245
56regulation of neurotransmitter levels (GO:0001505)3.08360525
57regulation of neuronal synaptic plasticity (GO:0048168)3.07999625
58pyrimidine nucleobase catabolic process (GO:0006208)3.07382123
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06023833
60response to histamine (GO:0034776)3.05286203
61electron transport chain (GO:0022900)3.05074934
62central nervous system myelination (GO:0022010)2.99270673
63axon ensheathment in central nervous system (GO:0032291)2.99270673
64protein complex biogenesis (GO:0070271)2.99043786
65ADP metabolic process (GO:0046031)2.96617946
66dendritic spine morphogenesis (GO:0060997)2.95935981
67mitochondrial respiratory chain complex I assembly (GO:0032981)2.95715380
68NADH dehydrogenase complex assembly (GO:0010257)2.95715380
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95715380
70inositol phosphate catabolic process (GO:0071545)2.94764837
71gamma-aminobutyric acid transport (GO:0015812)2.94710007
72dicarboxylic acid catabolic process (GO:0043649)2.93852744
73long-term synaptic potentiation (GO:0060291)2.92932911
74neurofilament cytoskeleton organization (GO:0060052)2.91674729
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90640262
76nucleobase catabolic process (GO:0046113)2.90571340
77regulation of vesicle fusion (GO:0031338)2.87452894
78negative regulation of heart rate (GO:0010459)2.87291899
79glycerophospholipid catabolic process (GO:0046475)2.87093188
80regulation of postsynaptic membrane potential (GO:0060078)2.86466037
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.85092785
82establishment of synaptic vesicle localization (GO:0097480)2.85053987
83synaptic vesicle transport (GO:0048489)2.85053987
84neurotransmitter-gated ion channel clustering (GO:0072578)2.83685022
85presynaptic membrane organization (GO:0097090)2.79918544
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79799441
87activation of protein kinase B activity (GO:0032148)2.79172185
88coenzyme catabolic process (GO:0009109)2.79105083
89catecholamine transport (GO:0051937)2.77217708
90axonal fasciculation (GO:0007413)2.76871817
91neuromuscular synaptic transmission (GO:0007274)2.76807882
92phagosome maturation (GO:0090382)2.76641368
93regulation of synaptic plasticity (GO:0048167)2.76236183
94behavioral response to cocaine (GO:0048148)2.74681929
95mitochondrial respiratory chain complex assembly (GO:0033108)2.73016860
96regulation of dopamine secretion (GO:0014059)2.73002325
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.72934218
98inner mitochondrial membrane organization (GO:0007007)2.71985526
99neuromuscular process controlling posture (GO:0050884)2.70437676
100heme transport (GO:0015886)2.68876927
101long-term memory (GO:0007616)2.68349546
102dopamine transport (GO:0015872)2.68327981
103iron coordination entity transport (GO:1901678)2.68150073
104peroxisome fission (GO:0016559)2.67905194
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67093036
106regulation of synaptic transmission, dopaminergic (GO:0032225)2.66560501
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66026376
108negative regulation of cation channel activity (GO:2001258)2.65510352
109regulation of feeding behavior (GO:0060259)2.64984930
1102-deoxyribonucleotide biosynthetic process (GO:0009265)2.63763018
111deoxyribose phosphate biosynthetic process (GO:0046385)2.63763018
112regulation of neurotransmitter secretion (GO:0046928)2.63239245
113positive regulation of mitochondrial fission (GO:0090141)2.62754102
114membrane depolarization (GO:0051899)2.62566335
115positive regulation of synapse assembly (GO:0051965)2.62372425
116regulation of cellular respiration (GO:0043457)2.60426200
117relaxation of smooth muscle (GO:0044557)2.60219677
118membrane hyperpolarization (GO:0060081)2.58851307
119proline transport (GO:0015824)2.56156479
120adult walking behavior (GO:0007628)2.55728347
121negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54971354
122negative regulation of cell killing (GO:0031342)2.54971354
123regulation of oxidative phosphorylation (GO:0002082)2.53428771
124C4-dicarboxylate transport (GO:0015740)2.52880914
125regulation of synaptic transmission, glutamatergic (GO:0051966)2.52538949
126response to pheromone (GO:0019236)2.52319186
127regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.51882456
128regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.51882456
129mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.50616155
130regulation of neurotransmitter transport (GO:0051588)2.50237873
131protein targeting to mitochondrion (GO:0006626)2.49863922
132detection of calcium ion (GO:0005513)2.49376949
133phosphorylated carbohydrate dephosphorylation (GO:0046838)2.48983726
134inositol phosphate dephosphorylation (GO:0046855)2.48983726
135negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.48587519
136neuronal ion channel clustering (GO:0045161)2.47533003
137regulation of voltage-gated calcium channel activity (GO:1901385)2.47525717
138regulation of autophagic vacuole assembly (GO:2000785)2.44435813
139calcium ion-dependent exocytosis (GO:0017156)2.42656237
140glycosphingolipid biosynthetic process (GO:0006688)2.41130570
141insulin secretion (GO:0030073)2.40204989
142synaptic vesicle endocytosis (GO:0048488)2.39363609
143retinal cone cell development (GO:0046549)2.36252464
144startle response (GO:0001964)2.35745035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.84899489
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.76545576
3GBX2_23144817_ChIP-Seq_PC3_Human3.86479842
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33074742
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26410044
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.08303520
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.92079565
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.84191115
9REST_21632747_ChIP-Seq_MESCs_Mouse2.73505136
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57560545
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55215272
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54090065
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.39788788
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.39518559
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31869820
16TAF15_26573619_Chip-Seq_HEK293_Human2.29685325
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.28101979
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25815733
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23851465
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22859994
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.20873088
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17560457
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16744795
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.13647091
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.09583319
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99637816
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94405344
28IGF1R_20145208_ChIP-Seq_DFB_Human1.93755939
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92486803
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.90064522
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87807011
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78204518
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76567506
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74923129
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.73134205
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72227851
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71230935
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.68739743
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.64653706
40SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.63350854
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59605662
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.58127453
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55695244
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55583261
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.53269968
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52664508
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.51320955
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51037822
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50638467
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46554061
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44874618
52VDR_22108803_ChIP-Seq_LS180_Human1.36989539
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36527229
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35984606
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35984606
56VDR_23849224_ChIP-Seq_CD4+_Human1.33280475
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.32524417
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27967152
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27657857
60SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25531357
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25310683
62RNF2_27304074_Chip-Seq_NSC_Mouse1.23771481
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23641936
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23620051
65ZNF274_21170338_ChIP-Seq_K562_Hela1.23213560
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21849531
67FUS_26573619_Chip-Seq_HEK293_Human1.20039620
68TP53_22573176_ChIP-Seq_HFKS_Human1.19893725
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19621727
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19106260
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17598303
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.16000630
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14316449
74CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13830047
75GABP_19822575_ChIP-Seq_HepG2_Human1.13507786
76DROSHA_22980978_ChIP-Seq_HELA_Human1.12849301
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11876991
78NCOR_22424771_ChIP-Seq_293T_Human1.09010638
79BP1_19119308_ChIP-ChIP_Hs578T_Human1.08812792
80EWS_26573619_Chip-Seq_HEK293_Human1.08740983
81CBP_20019798_ChIP-Seq_JUKART_Human1.08579516
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08579516
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.07082122
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06088020
85P300_19829295_ChIP-Seq_ESCs_Human1.05831901
86FOXP3_21729870_ChIP-Seq_TREG_Human1.04886072
87JUN_21703547_ChIP-Seq_K562_Human1.03756278
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03193844
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02886818
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02812318
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02238810
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01504031
93XRN2_22483619_ChIP-Seq_HELA_Human1.00887700
94* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00653408
95CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99319246
96SOX2_19829295_ChIP-Seq_ESCs_Human0.99232284
97NANOG_19829295_ChIP-Seq_ESCs_Human0.99232284
98* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98674222
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.98086961
100* TCF4_23295773_ChIP-Seq_U87_Human0.97691862
101* SMAD4_21799915_ChIP-Seq_A2780_Human0.97328607
102RNF2_27304074_Chip-Seq_ESCs_Mouse0.96799773
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96634727
104STAT3_23295773_ChIP-Seq_U87_Human0.94849083
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94825192
106ER_23166858_ChIP-Seq_MCF-7_Human0.94053359
107MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93866921
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93690561
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.93528781
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93263682
111ERA_21632823_ChIP-Seq_H3396_Human0.92554595
112IRF8_21731497_ChIP-ChIP_J774_Mouse0.91829318
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91387826
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90766412
115MYC_18940864_ChIP-ChIP_HL60_Human0.89910826
116GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89794581
117CIITA_25753668_ChIP-Seq_RAJI_Human0.88956572
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.88041305
119MYC_19829295_ChIP-Seq_ESCs_Human0.87485875
120E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86963122
121HTT_18923047_ChIP-ChIP_STHdh_Human0.86661250
122CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86192258
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86158735
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.85888890
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85044839
126EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84908690
127AR_25329375_ChIP-Seq_VCAP_Human0.84687209
128TTF2_22483619_ChIP-Seq_HELA_Human0.84446451
129* RUNX2_22187159_ChIP-Seq_PCA_Human0.84405474
130WDR5_24793694_ChIP-Seq_LNCAP_Human0.84123627
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84121078
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83324301
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83303715
134FOXH1_21741376_ChIP-Seq_EPCs_Human0.83185009
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82990915
136CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.81877613
137DCP1A_22483619_ChIP-Seq_HELA_Human0.81754617
138FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81641982
139AR_21572438_ChIP-Seq_LNCaP_Human0.80763877
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80206066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.35172125
2MP0004859_abnormal_synaptic_plasticity5.16849715
3MP0003635_abnormal_synaptic_transmissio3.68935826
4MP0001968_abnormal_touch/_nociception3.30633112
5MP0009046_muscle_twitch3.29273848
6MP0009745_abnormal_behavioral_response3.27127621
7MP0002064_seizures3.13059530
8MP0002063_abnormal_learning/memory/cond2.91560909
9MP0004270_analgesia2.80033375
10MP0001529_abnormal_vocalization2.78093226
11MP0002736_abnormal_nociception_after2.77218852
12MP0006276_abnormal_autonomic_nervous2.68839443
13MP0002572_abnormal_emotion/affect_behav2.62841987
14MP0002735_abnormal_chemical_nociception2.48920400
15MP0005423_abnormal_somatic_nervous2.47162797
16MP0002822_catalepsy2.27685978
17MP0002272_abnormal_nervous_system2.23730123
18MP0002734_abnormal_mechanical_nocicepti2.18086082
19MP0009780_abnormal_chondrocyte_physiolo2.17421356
20MP0001501_abnormal_sleep_pattern2.13017160
21MP0002733_abnormal_thermal_nociception2.01450081
22MP0001970_abnormal_pain_threshold1.98785445
23MP0001905_abnormal_dopamine_level1.98401590
24MP0005645_abnormal_hypothalamus_physiol1.95275533
25MP0001440_abnormal_grooming_behavior1.92293512
26MP0002067_abnormal_sensory_capabilities1.82241717
27MP0005551_abnormal_eye_electrophysiolog1.76399103
28MP0005386_behavior/neurological_phenoty1.67768173
29MP0004924_abnormal_behavior1.67768173
30MP0001486_abnormal_startle_reflex1.65488181
31MP0001188_hyperpigmentation1.64692691
32MP0008569_lethality_at_weaning1.57458564
33MP0008872_abnormal_physiological_respon1.54715284
34MP0004811_abnormal_neuron_physiology1.53364374
35MP0003136_yellow_coat_color1.48497413
36MP0002184_abnormal_innervation1.47957334
37MP0003329_amyloid_beta_deposits1.45496896
38MP0004142_abnormal_muscle_tone1.45380543
39MP0002557_abnormal_social/conspecific_i1.43431622
40MP0008789_abnormal_olfactory_epithelium1.43406226
41MP0000015_abnormal_ear_pigmentation1.39350325
42MP0003879_abnormal_hair_cell1.38151188
43MP0005174_abnormal_tail_pigmentation1.36502533
44MP0002160_abnormal_reproductive_system1.35457277
45MP0002653_abnormal_ependyma_morphology1.34265619
46MP0006072_abnormal_retinal_apoptosis1.30959995
47MP0000778_abnormal_nervous_system1.30510933
48MP0002066_abnormal_motor_capabilities/c1.28787295
49MP0003011_delayed_dark_adaptation1.25090424
50MP0005253_abnormal_eye_physiology1.23244016
51MP0001502_abnormal_circadian_rhythm1.18302129
52MP0002638_abnormal_pupillary_reflex1.17714919
53MP0005646_abnormal_pituitary_gland1.17510477
54MP0001984_abnormal_olfaction1.16081554
55MP0006292_abnormal_olfactory_placode1.14296063
56MP0006035_abnormal_mitochondrial_morpho1.14288589
57MP0000955_abnormal_spinal_cord1.11356789
58MP0001986_abnormal_taste_sensitivity1.10812321
59MP0003122_maternal_imprinting1.09723961
60MP0005410_abnormal_fertilization1.06615690
61MP0003787_abnormal_imprinting1.04168994
62MP0003172_abnormal_lysosome_physiology1.02576579
63MP0005379_endocrine/exocrine_gland_phen1.00900052
64MP0002882_abnormal_neuron_morphology0.98997106
65MP0003195_calcinosis0.95901650
66MP0002090_abnormal_vision0.93311273
67MP0001764_abnormal_homeostasis0.93309763
68MP0002909_abnormal_adrenal_gland0.93297809
69MP0004885_abnormal_endolymph0.93052354
70MP0004147_increased_porphyrin_level0.92712638
71MP0005409_darkened_coat_color0.91937307
72MP0005671_abnormal_response_to0.91928564
73MP0006036_abnormal_mitochondrial_physio0.90021332
74MP0008260_abnormal_autophagy0.88282316
75MP0001664_abnormal_digestion0.86120034
76MP0003123_paternal_imprinting0.85428955
77MP0004858_abnormal_nervous_system0.85126283
78MP0004742_abnormal_vestibular_system0.85075626
79MP0002152_abnormal_brain_morphology0.84068147
80MP0000749_muscle_degeneration0.82889642
81MP0002752_abnormal_somatic_nervous0.82621889
82MP0001485_abnormal_pinna_reflex0.82600242
83MP0003633_abnormal_nervous_system0.82339472
84MP0003698_abnormal_male_reproductive0.81658296
85MP0009697_abnormal_copulation0.81115349
86MP0008877_abnormal_DNA_methylation0.80433052
87MP0000569_abnormal_digit_pigmentation0.80261113
88MP0000631_abnormal_neuroendocrine_gland0.78191316
89MP0005499_abnormal_olfactory_system0.77600551
90MP0005394_taste/olfaction_phenotype0.77600551
91MP0000751_myopathy0.75723580
92MP0005332_abnormal_amino_acid0.75591013
93MP0005535_abnormal_body_temperature0.75549958
94MP0008874_decreased_physiological_sensi0.75083071
95MP0003806_abnormal_nucleotide_metabolis0.74957158
96MP0002102_abnormal_ear_morphology0.74783236
97MP0010386_abnormal_urinary_bladder0.74544862
98MP0004510_myositis0.74226890
99MP0002069_abnormal_eating/drinking_beha0.74145360
100MP0001944_abnormal_pancreas_morphology0.73628853
101MP0000604_amyloidosis0.73205147
102MP0002693_abnormal_pancreas_physiology0.73159621
103MP0003646_muscle_fatigue0.72984439
104MP0003763_abnormal_thymus_physiology0.72976669
105MP0002163_abnormal_gland_morphology0.72965397
106MP0003631_nervous_system_phenotype0.72812000
107MP0005389_reproductive_system_phenotype0.71762350
108MP0000681_abnormal_thyroid_gland0.70870109
109MP0002876_abnormal_thyroid_physiology0.70076823
110MP0002229_neurodegeneration0.68497633
111MP0001929_abnormal_gametogenesis0.68332684
112MP0000372_irregular_coat_pigmentation0.67904582
113MP0008058_abnormal_DNA_repair0.66764656
114MP0009379_abnormal_foot_pigmentation0.65624023
115MP0001177_atelectasis0.64931014
116MP0001963_abnormal_hearing_physiology0.63746017
117MP0003183_abnormal_peptide_metabolism0.63647995
118MP0005075_abnormal_melanosome_morpholog0.63251026
119MP0003121_genomic_imprinting0.59726863
120MP0003656_abnormal_erythrocyte_physiolo0.59200121
121MP0002398_abnormal_bone_marrow0.58821585
122MP0002420_abnormal_adaptive_immunity0.58790701
123MP0005000_abnormal_immune_tolerance0.56887840
124MP0001819_abnormal_immune_cell0.56749905
125MP0000013_abnormal_adipose_tissue0.56113139
126MP0003866_abnormal_defecation0.55824238
127MP0002095_abnormal_skin_pigmentation0.55180213
128MP0002723_abnormal_immune_serum0.54455618
129MP0002837_dystrophic_cardiac_calcinosis0.54259611
130MP0002083_premature_death0.52624526

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.28473840
2Myokymia (HP:0002411)4.47667603
3Focal seizures (HP:0007359)4.22567119
4Epileptic encephalopathy (HP:0200134)4.20165366
5Atonic seizures (HP:0010819)4.18195667
6Acute necrotizing encephalopathy (HP:0006965)4.04786934
7Mitochondrial inheritance (HP:0001427)4.02162826
8Hepatocellular necrosis (HP:0001404)3.98003145
9Visual hallucinations (HP:0002367)3.90411437
10Abnormal mitochondria in muscle tissue (HP:0008316)3.86597759
11Febrile seizures (HP:0002373)3.65585662
12Hypoglycemic coma (HP:0001325)3.57387851
13Absence seizures (HP:0002121)3.50232898
14Increased CSF lactate (HP:0002490)3.44718537
15Progressive macrocephaly (HP:0004481)3.24954773
16Acute encephalopathy (HP:0006846)3.23287272
17Hyperventilation (HP:0002883)3.15267193
18Dialeptic seizures (HP:0011146)3.14641120
19Generalized tonic-clonic seizures (HP:0002069)3.14399484
20Hyperinsulinemic hypoglycemia (HP:0000825)3.12338576
21Abnormality of the labia minora (HP:0012880)3.10298347
22Supranuclear gaze palsy (HP:0000605)3.05982868
23Hepatic necrosis (HP:0002605)3.02201060
24Abnormality of cochlea (HP:0000375)3.02151582
25Hypoglycemic seizures (HP:0002173)3.01540656
26Broad-based gait (HP:0002136)2.92384275
27Increased hepatocellular lipid droplets (HP:0006565)2.84214221
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78392329
29Papilledema (HP:0001085)2.76127419
30Delusions (HP:0000746)2.73589932
31Type II lissencephaly (HP:0007260)2.70681364
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.66773067
33Impaired vibration sensation in the lower limbs (HP:0002166)2.64436983
34Inability to walk (HP:0002540)2.63260042
353-Methylglutaconic aciduria (HP:0003535)2.62596990
36Ketoacidosis (HP:0001993)2.61510240
37Hypothermia (HP:0002045)2.61010386
38Emotional lability (HP:0000712)2.58365726
39Limb dystonia (HP:0002451)2.58270662
40Progressive inability to walk (HP:0002505)2.57858014
41Hyperthyroidism (HP:0000836)2.56675500
42Decreased activity of mitochondrial respiratory chain (HP:0008972)2.54668719
43Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.54668719
44Anxiety (HP:0000739)2.51553532
45Poor suck (HP:0002033)2.51343923
46Increased serum lactate (HP:0002151)2.49948391
47Amyotrophic lateral sclerosis (HP:0007354)2.49432567
48Lactic acidosis (HP:0003128)2.49099276
49Pheochromocytoma (HP:0002666)2.48824230
50Ankle clonus (HP:0011448)2.48729427
51Abnormal hair whorl (HP:0010721)2.47629307
52Ketosis (HP:0001946)2.46766633
53Dysdiadochokinesis (HP:0002075)2.46304217
54Lipid accumulation in hepatocytes (HP:0006561)2.44892733
55Hypomagnesemia (HP:0002917)2.44466154
56Polyphagia (HP:0002591)2.44104364
57Retinal dysplasia (HP:0007973)2.40352902
58Increased intramyocellular lipid droplets (HP:0012240)2.38705446
59Increased serum pyruvate (HP:0003542)2.37532204
60Abnormality of glycolysis (HP:0004366)2.37532204
61Neuroendocrine neoplasm (HP:0100634)2.37014177
62Epileptiform EEG discharges (HP:0011182)2.34926278
63Progressive cerebellar ataxia (HP:0002073)2.34915230
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.33750048
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.33750048
66Poor eye contact (HP:0000817)2.33748861
67Abnormality of magnesium homeostasis (HP:0004921)2.32793202
68Hypoplasia of the pons (HP:0012110)2.30617746
69Unsteady gait (HP:0002317)2.29579236
70Protruding tongue (HP:0010808)2.28206937
71Abnormality of aromatic amino acid family metabolism (HP:0004338)2.27810804
72Morphological abnormality of the inner ear (HP:0011390)2.26937664
73Abnormal eating behavior (HP:0100738)2.26672079
74Mutism (HP:0002300)2.26474397
75Congenital primary aphakia (HP:0007707)2.25462386
76Exercise intolerance (HP:0003546)2.22307159
77Diplopia (HP:0000651)2.20645770
78Abnormality of binocular vision (HP:0011514)2.20645770
79Action tremor (HP:0002345)2.19474963
80Renal Fanconi syndrome (HP:0001994)2.19243322
81Renal cortical cysts (HP:0000803)2.18978125
82IgM deficiency (HP:0002850)2.18651872
83Truncal ataxia (HP:0002078)2.17138070
84EEG with generalized epileptiform discharges (HP:0011198)2.16069132
85Respiratory failure (HP:0002878)2.15808336
86Abnormality of the pons (HP:0007361)2.15393783
87Impaired smooth pursuit (HP:0007772)2.14900898
88Thyroid-stimulating hormone excess (HP:0002925)2.13579545
89Nephrogenic diabetes insipidus (HP:0009806)2.13252094
90Cerebral hypomyelination (HP:0006808)2.10593801
91Gaze-evoked nystagmus (HP:0000640)2.08644175
92Spastic gait (HP:0002064)2.08605755
93Psychosis (HP:0000709)2.06633654
94Hypsarrhythmia (HP:0002521)2.05326213
95Bradykinesia (HP:0002067)2.05039561
96Amblyopia (HP:0000646)2.04937432
97Cortical visual impairment (HP:0100704)2.04749016
98Optic disc pallor (HP:0000543)2.03069120
99Intention tremor (HP:0002080)1.99267692
100Large eyes (HP:0001090)1.98669356
101Abnormality of the lower motor neuron (HP:0002366)1.97879269
102Sensory axonal neuropathy (HP:0003390)1.97681759
103Exertional dyspnea (HP:0002875)1.97079114
104Abnormality of the corticospinal tract (HP:0002492)1.96565163
105Depression (HP:0000716)1.95566113
106Hemiparesis (HP:0001269)1.94568915
107Abnormality of endocrine pancreas physiology (HP:0012093)1.93920148
108Abnormality of the pancreatic islet cells (HP:0006476)1.93920148
109Lissencephaly (HP:0001339)1.92865948
110Opisthotonus (HP:0002179)1.90825776
111Leukodystrophy (HP:0002415)1.90678670
112Gait imbalance (HP:0002141)1.90156160
113Esotropia (HP:0000565)1.89730294
114Postural instability (HP:0002172)1.89159374
115Fetal akinesia sequence (HP:0001989)1.88763534
116Postnatal microcephaly (HP:0005484)1.88511092
117Spastic tetraplegia (HP:0002510)1.88393683
118Reduced antithrombin III activity (HP:0001976)1.88172987
119Muscular hypotonia of the trunk (HP:0008936)1.86377720
120Urinary bladder sphincter dysfunction (HP:0002839)1.85403098
121Abnormality of ocular smooth pursuit (HP:0000617)1.84811600
122Gliosis (HP:0002171)1.83469816
123Increased muscle lipid content (HP:0009058)1.83085919
124Cerebral edema (HP:0002181)1.83012070
125Urinary urgency (HP:0000012)1.81849467
126Abnormality of cells of the erythroid lineage (HP:0012130)1.80589468
127Increased circulating renin level (HP:0000848)1.79650002
128Abnormal number of erythroid precursors (HP:0012131)1.79316178
129Congenital stationary night blindness (HP:0007642)1.79161898
130CNS hypomyelination (HP:0003429)1.78967744
131Medial flaring of the eyebrow (HP:0010747)1.78670427
132Poor coordination (HP:0002370)1.78378018
133Abnormality of the metopic suture (HP:0005556)1.78232580
134Metaphyseal dysplasia (HP:0100255)1.77377471
135Methylmalonic acidemia (HP:0002912)1.77291239
136Symptomatic seizures (HP:0011145)1.77234974
137Gout (HP:0001997)1.75029841
138Status epilepticus (HP:0002133)1.72025744
139Hyperglycinemia (HP:0002154)1.71612461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.77777779
2PINK14.12864827
3NTRK33.64052021
4EPHA43.45934165
5MAP2K73.12896817
6CASK2.91890441
7DAPK12.91685759
8FRK2.90040937
9TNIK2.57855590
10MAP3K42.47778828
11MAP3K92.36169440
12MAP4K22.26060343
13MARK12.20154870
14MINK12.11185147
15DAPK22.07213231
16PRKD32.06996807
17CSNK1A1L1.96583953
18CDK191.83580032
19NTRK21.80569968
20SIK21.79618599
21MAP2K41.79164165
22GRK51.75453810
23ZAK1.70296147
24TRIM281.67484763
25ARAF1.65733939
26STK161.65013482
27RIPK41.62711277
28FES1.60261185
29CCNB11.54608242
30CSNK1G11.52099674
31LMTK21.48922527
32MAP4K11.47061079
33PAK61.46212262
34PHKG21.45756393
35PHKG11.45756393
36FGFR21.45728269
37CAMKK21.42795773
38GRK71.41363874
39GRK11.40288235
40PIK3CA1.40101157
41PAK31.39325344
42VRK11.38734535
43SGK2231.38429042
44SGK4941.38429042
45MARK31.37871862
46NME11.37574028
47MAPK131.33350388
48BUB11.32567444
49GRK61.31751857
50EIF2AK31.28334256
51PLK21.22378670
52TSSK61.21493817
53PNCK1.18963946
54MAP3K111.15254880
55BCKDK1.12085103
56CDK51.08161099
57WNK31.07324801
58SYK1.07126824
59LIMK10.99005192
60MAP3K60.98383687
61TXK0.97691674
62ZAP700.95527527
63DAPK30.94895449
64INSRR0.93344600
65BLK0.93118088
66PRKCG0.92881153
67OBSCN0.92837429
68SGK20.86214118
69ACVR1B0.83952552
70SCYL20.81920110
71TNK20.81321346
72CAMKK10.80843892
73DYRK30.79868104
74STK110.77615748
75CAMK2A0.75983939
76UHMK10.75627862
77CDK180.74723923
78BRAF0.73898681
79CAMK2B0.73865231
80CDK150.73312494
81NTRK10.72884304
82RPS6KA50.71997056
83RPS6KA40.71027558
84PIM20.70353181
85CDK30.70107251
86CDK140.68304815
87ADRBK10.66518758
88NME20.65997042
89CDK11A0.64413190
90CAMK10.63413043
91WEE10.63308170
92CAMK40.62130609
93FGR0.62006076
94CSNK1G20.61551403
95BMPR1B0.60787610
96CAMK2G0.60670920
97DYRK1A0.59808514
98MYLK0.58244201
99KSR10.55694614
100BRSK10.55549537
101KIT0.55168155
102WNK40.54682849
103STK390.53858964
104SIK30.53297360
105PRKCQ0.52668049
106DYRK20.52194031
107PKN10.51914628
108CSNK1A10.51113531
109PRPF4B0.50854145
110MUSK0.50782427
111OXSR10.49970113
112PTK2B0.49941194
113MAP3K130.49575011
114CSNK1G30.49554698
115RAF10.47652223
116BMPR20.45483118
117NUAK10.45408297
118RPS6KB10.44715990
119STK38L0.43836001
120SGK10.43241359
121MAP2K60.43051170
122CSNK1E0.42911005
123PRKCH0.42484282
124ADRBK20.41967592
125PRKACA0.40281358
126KSR20.39601360
127PLK10.38529291
128PDK10.37285063
129MAPK40.37116110
130CSF1R0.37052776
131TAOK10.36527039
132AKT20.35893209
133PAK10.35731513
134MATK0.34532124
135MAPK120.34210618
136CSNK1D0.33698839
137LYN0.32813430
138MOS0.32504790
139MAPKAPK50.32343495
140TLK10.30505453
141CAMK2D0.30466471
142BTK0.30271551
143LCK0.28217015
144MAP3K50.28143880
145TESK20.27843693
146MAP3K10.27807235
147FYN0.26956216
148ROCK20.26177270

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.07628234
2Synaptic vesicle cycle_Homo sapiens_hsa047213.77635747
3Oxidative phosphorylation_Homo sapiens_hsa001903.42960248
4Collecting duct acid secretion_Homo sapiens_hsa049662.93492572
5Parkinsons disease_Homo sapiens_hsa050122.79275721
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57713275
7Folate biosynthesis_Homo sapiens_hsa007902.52203865
8Alzheimers disease_Homo sapiens_hsa050102.44225399
9Amphetamine addiction_Homo sapiens_hsa050312.28759551
10Proteasome_Homo sapiens_hsa030502.27955021
11Morphine addiction_Homo sapiens_hsa050322.20579201
12GABAergic synapse_Homo sapiens_hsa047272.18343102
13Long-term potentiation_Homo sapiens_hsa047202.17311175
14Olfactory transduction_Homo sapiens_hsa047402.12846318
15Circadian entrainment_Homo sapiens_hsa047132.08934341
16Vibrio cholerae infection_Homo sapiens_hsa051102.05338808
17Butanoate metabolism_Homo sapiens_hsa006501.99374056
18Dopaminergic synapse_Homo sapiens_hsa047281.93082513
19Vitamin B6 metabolism_Homo sapiens_hsa007501.89423592
20Huntingtons disease_Homo sapiens_hsa050161.85966067
21Glutamatergic synapse_Homo sapiens_hsa047241.84143692
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82490521
23Taste transduction_Homo sapiens_hsa047421.77949042
24Propanoate metabolism_Homo sapiens_hsa006401.59193628
25Fatty acid elongation_Homo sapiens_hsa000621.58612345
26Ribosome_Homo sapiens_hsa030101.54198415
27Serotonergic synapse_Homo sapiens_hsa047261.52807459
28Cocaine addiction_Homo sapiens_hsa050301.45999603
29Cardiac muscle contraction_Homo sapiens_hsa042601.41764988
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41637817
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40605472
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38365911
33Long-term depression_Homo sapiens_hsa047301.37256122
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36075178
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35622938
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34527057
37Salivary secretion_Homo sapiens_hsa049701.33146796
38Calcium signaling pathway_Homo sapiens_hsa040201.27734306
39Cholinergic synapse_Homo sapiens_hsa047251.27095004
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26366704
41Renin secretion_Homo sapiens_hsa049241.22554871
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.22307505
43Sulfur relay system_Homo sapiens_hsa041221.21413416
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21186747
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20164993
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15872898
47Insulin secretion_Homo sapiens_hsa049111.14002088
48Gastric acid secretion_Homo sapiens_hsa049711.11943232
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11766155
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10810930
51Rheumatoid arthritis_Homo sapiens_hsa053231.10369613
52Peroxisome_Homo sapiens_hsa041461.09691965
53beta-Alanine metabolism_Homo sapiens_hsa004101.05388231
54DNA replication_Homo sapiens_hsa030301.03230805
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02068611
56Oxytocin signaling pathway_Homo sapiens_hsa049210.99341675
57RNA degradation_Homo sapiens_hsa030180.97301539
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96772023
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95515340
60Circadian rhythm_Homo sapiens_hsa047100.94314411
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91798990
62Nitrogen metabolism_Homo sapiens_hsa009100.91427373
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90282408
64Arginine biosynthesis_Homo sapiens_hsa002200.90041329
65Gap junction_Homo sapiens_hsa045400.88617599
66Arginine and proline metabolism_Homo sapiens_hsa003300.88524687
67RNA polymerase_Homo sapiens_hsa030200.88479829
68Type I diabetes mellitus_Homo sapiens_hsa049400.87732311
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87072355
70Mismatch repair_Homo sapiens_hsa034300.86610882
71Primary immunodeficiency_Homo sapiens_hsa053400.86255266
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84271526
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81828995
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.81014607
75Protein export_Homo sapiens_hsa030600.80916465
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80167496
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78780831
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78408218
79Phagosome_Homo sapiens_hsa041450.78366274
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77448628
81Fatty acid metabolism_Homo sapiens_hsa012120.77249839
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74759321
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73504765
84Metabolic pathways_Homo sapiens_hsa011000.73003798
85N-Glycan biosynthesis_Homo sapiens_hsa005100.72663416
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72591468
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72357582
88Pyruvate metabolism_Homo sapiens_hsa006200.71910742
89Alcoholism_Homo sapiens_hsa050340.71732107
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69736054
91GnRH signaling pathway_Homo sapiens_hsa049120.68233105
92Basal transcription factors_Homo sapiens_hsa030220.67478318
93Carbon metabolism_Homo sapiens_hsa012000.67151071
94One carbon pool by folate_Homo sapiens_hsa006700.64930189
95Pyrimidine metabolism_Homo sapiens_hsa002400.64148135
96Oocyte meiosis_Homo sapiens_hsa041140.63697873
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.63471554
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63068382
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60838144
100Ether lipid metabolism_Homo sapiens_hsa005650.56972259
101Pancreatic secretion_Homo sapiens_hsa049720.56675408
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55957248
103Glucagon signaling pathway_Homo sapiens_hsa049220.55453670
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55344890
105Purine metabolism_Homo sapiens_hsa002300.54090612
106Steroid biosynthesis_Homo sapiens_hsa001000.53947949
107Tryptophan metabolism_Homo sapiens_hsa003800.53683256
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53160541
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50412089
110cAMP signaling pathway_Homo sapiens_hsa040240.49847577
111Other glycan degradation_Homo sapiens_hsa005110.49448743
112Fatty acid degradation_Homo sapiens_hsa000710.45406770
113Estrogen signaling pathway_Homo sapiens_hsa049150.44927144
114Base excision repair_Homo sapiens_hsa034100.43404177
115Nucleotide excision repair_Homo sapiens_hsa034200.42904485
116Fructose and mannose metabolism_Homo sapiens_hsa000510.42792293
117Fanconi anemia pathway_Homo sapiens_hsa034600.42486227
118Phenylalanine metabolism_Homo sapiens_hsa003600.42340854
119Axon guidance_Homo sapiens_hsa043600.41777344
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39605513
121Glutathione metabolism_Homo sapiens_hsa004800.39319450
122T cell receptor signaling pathway_Homo sapiens_hsa046600.38870968
123Melanogenesis_Homo sapiens_hsa049160.36918728
124Spliceosome_Homo sapiens_hsa030400.36745315
125Regulation of autophagy_Homo sapiens_hsa041400.36147101
126Tuberculosis_Homo sapiens_hsa051520.35068967
127Shigellosis_Homo sapiens_hsa051310.35053999
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34567201
129African trypanosomiasis_Homo sapiens_hsa051430.33619927
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33125810
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32664114
132Salmonella infection_Homo sapiens_hsa051320.32242022
133Phototransduction_Homo sapiens_hsa047440.27836913
134MAPK signaling pathway_Homo sapiens_hsa040100.27126339
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26815081
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23815951
137Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23727720
138Colorectal cancer_Homo sapiens_hsa052100.23082299
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.22824796
140Glioma_Homo sapiens_hsa052140.21931614
141Homologous recombination_Homo sapiens_hsa034400.20608030
142Type II diabetes mellitus_Homo sapiens_hsa049300.20083623

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