ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of mesoderm development (GO:2000380)	7.45316060
2	negative regulation of activin receptor signaling pathway (GO:0032926)	6.28851637
3	phospholipid scrambling (GO:0017121)	6.26143214
4	somite rostral/caudal axis specification (GO:0032525)	6.20979285
5	cell migration involved in gastrulation (GO:0042074)	5.53082422
6	endoderm formation (GO:0001706)	5.19055357
7	sequestering of extracellular ligand from receptor (GO:0035581)	5.16393095
8	primitive streak formation (GO:0090009)	4.76500217
9	DNA replication checkpoint (GO:0000076)	4.42618025
10	positive regulation of gastrulation (GO:2000543)	4.42486777
11	anterior/posterior axis specification (GO:0009948)	4.40577351
12	signal transduction involved in regulation of gene expression (GO:0023019)	4.30833283
13	regulation of activin receptor signaling pathway (GO:0032925)	4.28024382
14	DNA replication-dependent nucleosome organization (GO:0034723)	4.24357125
15	DNA replication-dependent nucleosome assembly (GO:0006335)	4.24357125
16	regulation of acrosome reaction (GO:0060046)	4.16903988
17	multicellular organism reproduction (GO:0032504)	4.10692411
18	nodal signaling pathway (GO:0038092)	4.08329643
19	meiotic chromosome segregation (GO:0045132)	4.00371745
20	piRNA metabolic process (GO:0034587)	3.96029170
21	embryonic axis specification (GO:0000578)	3.85278395
22	GDP-mannose metabolic process (GO:0019673)	3.72218996
23	DNA methylation involved in gamete generation (GO:0043046)	3.71777193
24	behavioral response to nicotine (GO:0035095)	3.69822678
25	embryonic pattern specification (GO:0009880)	3.58797375
26	DNA deamination (GO:0045006)	3.54480686
27	DNA strand renaturation (GO:0000733)	3.49728829
28	anterior/posterior axis specification, embryo (GO:0008595)	3.41261686
29	L-serine transport (GO:0015825)	3.38764179
30	regulation of female gonad development (GO:2000194)	3.35740859
31	CENP-A containing nucleosome assembly (GO:0034080)	3.34501934
32	chromatin remodeling at centromere (GO:0031055)	3.25693696
33	replication fork processing (GO:0031297)	3.24250998
34	DNA double-strand break processing (GO:0000729)	3.21645332
35	histone exchange (GO:0043486)	3.16667643
36	negative regulation of T cell differentiation in thymus (GO:0033085)	3.14629409
37	synapsis (GO:0007129)	3.12119409
38	cellular response to ATP (GO:0071318)	3.03731709
39	vitamin catabolic process (GO:0009111)	3.02843758
40	fat-soluble vitamin catabolic process (GO:0042363)	3.02843758
41	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.01536819
42	preassembly of GPI anchor in ER membrane (GO:0016254)	3.00985362
43	keratinocyte development (GO:0003334)	2.99816108
44	nucleotide transmembrane transport (GO:1901679)	2.99576577
45	regulation of gastrulation (GO:0010470)	2.94118230
46	rRNA methylation (GO:0031167)	2.93603785
47	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.92636474
48	gastrulation (GO:0007369)	2.92565961
49	regulation of female receptivity (GO:0045924)	2.92095244
50	purine nucleotide transport (GO:0015865)	2.89949635
51	extracellular regulation of signal transduction (GO:1900115)	2.88314525
52	extracellular negative regulation of signal transduction (GO:1900116)	2.88314525
53	mRNA cleavage (GO:0006379)	2.87991479
54	axis specification (GO:0009798)	2.86180056
55	cellular response to BMP stimulus (GO:0071773)	2.85759074
56	response to BMP (GO:0071772)	2.85759074
57	centriole replication (GO:0007099)	2.84596545
58	embryonic foregut morphogenesis (GO:0048617)	2.82259606
59	dorsal/ventral axis specification (GO:0009950)	2.79071115
60	urogenital system development (GO:0001655)	2.77962561
61	rRNA modification (GO:0000154)	2.77092134
62	oocyte development (GO:0048599)	2.73769255
63	meiotic cell cycle (GO:0051321)	2.73667219
64	epithelial cilium movement (GO:0003351)	2.70028417
65	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.69493486
66	reciprocal DNA recombination (GO:0035825)	2.68533574
67	reciprocal meiotic recombination (GO:0007131)	2.68533574
68	positive regulation of protein kinase C signaling (GO:0090037)	2.68409057
69	resolution of meiotic recombination intermediates (GO:0000712)	2.68180570
70	negative regulation of reproductive process (GO:2000242)	2.67567399
71	heme transport (GO:0015886)	2.66419880
72	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.64710362
73	base-excision repair, AP site formation (GO:0006285)	2.64587727
74	serine transport (GO:0032329)	2.63226538
75	gonadal mesoderm development (GO:0007506)	2.61386934
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.59734790
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.59734790
78	mannosylation (GO:0097502)	2.55809039
79	lung secretory cell differentiation (GO:0061140)	2.55789885
80	nucleotide transport (GO:0006862)	2.55420660
81	female mating behavior (GO:0060180)	2.54702694
82	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.53554661
83	female gamete generation (GO:0007292)	2.52346022
84	kidney morphogenesis (GO:0060993)	2.51309100
85	interferon-gamma production (GO:0032609)	2.50851586
86	centriole assembly (GO:0098534)	2.49942316
87	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.49893761
88	genitalia morphogenesis (GO:0035112)	2.49295229
89	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.46904302
90	female gonad development (GO:0008585)	2.46835483
91	GPI anchor metabolic process (GO:0006505)	2.44422263
92	gene silencing by RNA (GO:0031047)	2.44253254
93	positive regulation of catecholamine secretion (GO:0033605)	2.44065915
94	GPI anchor biosynthetic process (GO:0006506)	2.43990072
95	regulation of meiosis I (GO:0060631)	2.43982915
96	response to pheromone (GO:0019236)	2.41615022
97	regulation of skeletal muscle contraction (GO:0014819)	2.40938682
98	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.38900638
99	retinal cone cell development (GO:0046549)	2.38552660
100	sialylation (GO:0097503)	2.37573576

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.77270332
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.26542969
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.98548309
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89412364
5	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.84556593
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.69530730
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.65004217
8	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.53962089
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.53438257
10	VDR_22108803_ChIP-Seq_LS180_Human	2.46724799
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.43426849
12	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.31692925
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27181719
14	SMAD3_21741376_ChIP-Seq_HESCs_Human	2.27127160
15	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.26466402
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.07440811
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.00444995
18	EWS_26573619_Chip-Seq_HEK293_Human	1.97230508
19	* SMAD4_21741376_ChIP-Seq_HESCs_Human	1.93181269
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.89631808
21	ERA_21632823_ChIP-Seq_H3396_Human	1.84418139
22	TP53_22573176_ChIP-Seq_HFKS_Human	1.84203064
23	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.78996027
24	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.69248016
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.64973218
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.63511552
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.61801432
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.59667228
29	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.58716720
30	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.54340054
31	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.53106985
32	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.50467048
33	FUS_26573619_Chip-Seq_HEK293_Human	1.48679905
34	EOMES_21245162_ChIP-Seq_HESCs_Human	1.48150252
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47987735
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.47337275
37	NANOG_20526341_ChIP-Seq_ESCs_Human	1.46970578
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.46561109
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.46404057
40	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46188913
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.45108326
42	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43662431
43	HOXB7_26014856_ChIP-Seq_BT474_Human	1.42523729
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.41951108
45	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.40723478
46	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.34224598
47	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.31077969
48	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.31077969
49	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.31077969
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30035357
51	P300_19829295_ChIP-Seq_ESCs_Human	1.29469734
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.28946568
53	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25049741
54	ELF5_23300383_ChIP-Seq_T47D_Human	1.23145918
55	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22049922
56	GBX2_23144817_ChIP-Seq_PC3_Human	1.21342644
57	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.19612030
58	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.18751532
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.17678216
60	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17678216
61	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.16055444
62	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.14153422
63	NCOR_22424771_ChIP-Seq_293T_Human	1.14126658
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13604717
65	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.13540370
66	OCT4_20526341_ChIP-Seq_ESCs_Human	1.08985910
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06920568
68	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05623883
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.05409730
70	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.04243092
71	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.03217008
72	KDM5A_27292631_Chip-Seq_BREAST_Human	1.02366073
73	* P53_21459846_ChIP-Seq_SAOS-2_Human	1.02135434
74	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.00504829
75	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.00356076
76	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.00191062
77	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.98462565
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98413718
79	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.96361416
80	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96311283
81	RNF2_27304074_Chip-Seq_NSC_Mouse	0.95904341
82	RUNX2_22187159_ChIP-Seq_PCA_Human	0.95479622
83	XRN2_22483619_ChIP-Seq_HELA_Human	0.94254874
84	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.93838972
85	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.93059034
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.92443667
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92429336
88	AR_20517297_ChIP-Seq_VCAP_Human	0.92408178
89	BCL6_27268052_Chip-Seq_Bcells_Human	0.92013940
90	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.92012204
91	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92012204
92	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.91814322
93	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.91814322
94	SOX2_19829295_ChIP-Seq_ESCs_Human	0.91685141
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.91685141
96	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91458804
97	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.91138224
98	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.90969224
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.90293421
100	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.89707909

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003890_abnormal_embryonic-extraembry	7.00574647
2	MP0005499_abnormal_olfactory_system	3.67326749
3	MP0005394_taste/olfaction_phenotype	3.67326749
4	MP0003136_yellow_coat_color	3.19106604
5	MP0005423_abnormal_somatic_nervous	2.98800610
6	MP0001986_abnormal_taste_sensitivity	2.75736488
7	MP0003119_abnormal_digestive_system	2.64610876
8	MP0005174_abnormal_tail_pigmentation	2.61382905
9	MP0001968_abnormal_touch/_nociception	2.42961051
10	MP0010030_abnormal_orbit_morphology	2.42811730
11	MP0004133_heterotaxia	2.31448048
12	MP0008789_abnormal_olfactory_epithelium	2.29788395
13	MP0002736_abnormal_nociception_after	2.25911978
14	MP0008995_early_reproductive_senescence	2.22798573
15	MP0003195_calcinosis	2.19102823
16	MP0008877_abnormal_DNA_methylation	2.06596613
17	MP0001984_abnormal_olfaction	2.02266753
18	MP0006292_abnormal_olfactory_placode	2.01869645
19	MP0003718_maternal_effect	2.00612161
20	MP0008004_abnormal_stomach_pH	1.98403955
21	MP0002254_reproductive_system_inflammat	1.90390999
22	MP0005171_absent_coat_pigmentation	1.89092461
23	MP0008872_abnormal_physiological_respon	1.61091999
24	MP0001188_hyperpigmentation	1.56790213
25	MP0005551_abnormal_eye_electrophysiolog	1.55589389
26	MP0008875_abnormal_xenobiotic_pharmacok	1.55369224
27	MP0002638_abnormal_pupillary_reflex	1.45563328
28	MP0002938_white_spotting	1.44336824
29	MP0003880_abnormal_central_pattern	1.41729876
30	MP0002210_abnormal_sex_determination	1.38096667
31	MP0005083_abnormal_biliary_tract	1.37818299
32	MP0001929_abnormal_gametogenesis	1.32148772
33	MP0006072_abnormal_retinal_apoptosis	1.31134487
34	MP0003137_abnormal_impulse_conducting	1.30076795
35	MP0008058_abnormal_DNA_repair	1.25862686
36	MP0002160_abnormal_reproductive_system	1.23262303
37	MP0002102_abnormal_ear_morphology	1.23172601
38	MP0000372_irregular_coat_pigmentation	1.22503250
39	MP0010094_abnormal_chromosome_stability	1.18874244
40	MP0006276_abnormal_autonomic_nervous	1.18760419
41	MP0002277_abnormal_respiratory_mucosa	1.16601182
42	MP0000538_abnormal_urinary_bladder	1.14981790
43	MP0003693_abnormal_embryo_hatching	1.14562745
44	MP0005410_abnormal_fertilization	1.11252872
45	MP0000653_abnormal_sex_gland	1.10787435
46	MP0000427_abnormal_hair_cycle	1.07241490
47	MP0001485_abnormal_pinna_reflex	1.06448388
48	MP0002751_abnormal_autonomic_nervous	1.05963834
49	MP0003936_abnormal_reproductive_system	1.04282537
50	MP0001502_abnormal_circadian_rhythm	1.02436556
51	MP0008057_abnormal_DNA_replication	1.02118150
52	MP0002084_abnormal_developmental_patter	1.00689317
53	MP0001145_abnormal_male_reproductive	0.96532787
54	MP0005380_embryogenesis_phenotype	0.96088617
55	MP0001672_abnormal_embryogenesis/_devel	0.96088617
56	MP0003937_abnormal_limbs/digits/tail_de	0.95876475
57	MP0005646_abnormal_pituitary_gland	0.92563745
58	MP0003698_abnormal_male_reproductive	0.92525380
59	MP0002127_abnormal_cardiovascular_syste	0.91114283
60	MP0001119_abnormal_female_reproductive	0.89600092
61	MP0003786_premature_aging	0.89592801
62	MP0004264_abnormal_extraembryonic_tissu	0.89043601
63	MP0002111_abnormal_tail_morphology	0.88962291
64	MP0001293_anophthalmia	0.88692568
65	MP0002233_abnormal_nose_morphology	0.86791660
66	MP0002735_abnormal_chemical_nociception	0.85908425
67	MP0008932_abnormal_embryonic_tissue	0.85418697
68	MP0001286_abnormal_eye_development	0.84329344
69	MP0005253_abnormal_eye_physiology	0.83908351
70	MP0002653_abnormal_ependyma_morphology	0.83249196
71	MP0006054_spinal_hemorrhage	0.82480177
72	MP0004085_abnormal_heartbeat	0.82381875
73	MP0000470_abnormal_stomach_morphology	0.80341978
74	MP0000015_abnormal_ear_pigmentation	0.80275358
75	MP0001756_abnormal_urination	0.80091202
76	MP0003943_abnormal_hepatobiliary_system	0.79197534
77	MP0005389_reproductive_system_phenotype	0.79133039
78	MP0004043_abnormal_pH_regulation	0.78975203
79	MP0001529_abnormal_vocalization	0.78490425
80	MP0001919_abnormal_reproductive_system	0.77468108
81	MP0000049_abnormal_middle_ear	0.76667049
82	MP0002752_abnormal_somatic_nervous	0.75567417
83	MP0003699_abnormal_female_reproductive	0.74274656
84	MP0000631_abnormal_neuroendocrine_gland	0.72800132
85	MP0004381_abnormal_hair_follicle	0.72502455
86	MP0002234_abnormal_pharynx_morphology	0.72091146
87	MP0003385_abnormal_body_wall	0.71409050
88	MP0002161_abnormal_fertility/fecundity	0.70880037
89	MP0004145_abnormal_muscle_electrophysio	0.69945547
90	MP0001664_abnormal_digestion	0.69158647
91	MP0006035_abnormal_mitochondrial_morpho	0.68975796
92	MP0003935_abnormal_craniofacial_develop	0.68490820
93	MP0003077_abnormal_cell_cycle	0.68429585
94	MP0002282_abnormal_trachea_morphology	0.68373129
95	MP0004957_abnormal_blastocyst_morpholog	0.67607679
96	MP0005365_abnormal_bile_salt	0.66991937
97	MP0003755_abnormal_palate_morphology	0.66777732
98	MP0004084_abnormal_cardiac_muscle	0.66752430
99	MP0000026_abnormal_inner_ear	0.66312809
100	MP0004924_abnormal_behavior	0.65922471

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of abdominal situs (HP:0011620)	3.85541907
2	Abdominal situs inversus (HP:0003363)	3.85541907
3	Rectal fistula (HP:0100590)	3.74764221
4	Rectovaginal fistula (HP:0000143)	3.74764221
5	Rib fusion (HP:0000902)	3.70528017
6	Congenital malformation of the right heart (HP:0011723)	3.36600432
7	Double outlet right ventricle (HP:0001719)	3.36600432
8	Intestinal fistula (HP:0100819)	3.36042326
9	Vaginal fistula (HP:0004320)	3.18288728
10	Abnormal pancreas size (HP:0012094)	3.10381744
11	Birth length less than 3rd percentile (HP:0003561)	2.97282942
12	Attenuation of retinal blood vessels (HP:0007843)	2.92721373
13	Absent radius (HP:0003974)	2.89528133
14	Ependymoma (HP:0002888)	2.87669157
15	Septo-optic dysplasia (HP:0100842)	2.84928516
16	Abnormal biliary tract physiology (HP:0012439)	2.79619598
17	Bile duct proliferation (HP:0001408)	2.79619598
18	Aplasia involving forearm bones (HP:0009822)	2.76931388
19	Absent forearm bone (HP:0003953)	2.76931388
20	Oligodactyly (hands) (HP:0001180)	2.68419292
21	Hypoplasia of the pons (HP:0012110)	2.61517413
22	Abnormality of the pons (HP:0007361)	2.60559610
23	Concave nail (HP:0001598)	2.59021939
24	Congenital stationary night blindness (HP:0007642)	2.58539771
25	Abnormality of midbrain morphology (HP:0002418)	2.56197082
26	Molar tooth sign on MRI (HP:0002419)	2.56197082
27	Bony spicule pigmentary retinopathy (HP:0007737)	2.51239398
28	Anal stenosis (HP:0002025)	2.47484356
29	Patellar aplasia (HP:0006443)	2.42369430
30	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.39212368
31	Testicular atrophy (HP:0000029)	2.37738309
32	Facial hemangioma (HP:0000329)	2.36819033
33	Hyperglycinuria (HP:0003108)	2.36452542
34	Abnormality of the fetal cardiovascular system (HP:0010948)	2.35703986
35	Abnormal umbilical cord blood vessels (HP:0011403)	2.35703986
36	Single umbilical artery (HP:0001195)	2.35703986
37	Stomach cancer (HP:0012126)	2.34948748
38	Methylmalonic acidemia (HP:0002912)	2.34696244
39	Absent thumb (HP:0009777)	2.33359011
40	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.30910874
41	Anophthalmia (HP:0000528)	2.29840954
42	Hypoplastic pelvis (HP:0008839)	2.29823988
43	Astrocytoma (HP:0009592)	2.28586003
44	Abnormality of the astrocytes (HP:0100707)	2.28586003
45	Nephronophthisis (HP:0000090)	2.28269689
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.27861689
47	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.27793899
48	Pancreatic cysts (HP:0001737)	2.26253255
49	Abnormality of the parathyroid morphology (HP:0011766)	2.26013497
50	Aplasia/Hypoplasia of the patella (HP:0006498)	2.22778128
51	Intestinal atresia (HP:0011100)	2.22356402
52	Abnormal drinking behavior (HP:0030082)	2.17783806
53	Polydipsia (HP:0001959)	2.17783806
54	Anteriorly placed anus (HP:0001545)	2.16223052
55	Progressive inability to walk (HP:0002505)	2.15657131
56	Short humerus (HP:0005792)	2.14329383
57	Aplasia/hypoplasia of the humerus (HP:0006507)	2.14266065
58	Gonadotropin excess (HP:0000837)	2.14098941
59	Pancreatic fibrosis (HP:0100732)	2.11175139
60	Asplenia (HP:0001746)	2.10650339
61	Optic nerve hypoplasia (HP:0000609)	2.09944399
62	Short thumb (HP:0009778)	2.08741927
63	Aplasia of the musculature (HP:0100854)	2.07198419
64	Glioma (HP:0009733)	2.04446256
65	Type I transferrin isoform profile (HP:0003642)	2.03605051
66	Hypoplasia of the fovea (HP:0007750)	2.00465367
67	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.00465367
68	Poikiloderma (HP:0001029)	2.00141870
69	Small hand (HP:0200055)	1.98491038
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.97539877
71	Type II lissencephaly (HP:0007260)	1.97391528
72	Chronic hepatic failure (HP:0100626)	1.95874407
73	Abnormality of the renal medulla (HP:0100957)	1.94513388
74	Decreased circulating renin level (HP:0003351)	1.94351246
75	Methylmalonic aciduria (HP:0012120)	1.93499834
76	Microretrognathia (HP:0000308)	1.93416184
77	Dyschromatopsia (HP:0007641)	1.92740792
78	Anencephaly (HP:0002323)	1.92145185
79	Increased number of teeth (HP:0011069)	1.89518812
80	Facial diplegia (HP:0001349)	1.88910306
81	Abnormality of the renal cortex (HP:0011035)	1.86516161
82	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.83845059
83	Abnormal protein N-linked glycosylation (HP:0012347)	1.83165912
84	Abnormal protein glycosylation (HP:0012346)	1.83165912
85	Abnormal glycosylation (HP:0012345)	1.83165912
86	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.83165912
87	Labial hypoplasia (HP:0000066)	1.82344642
88	Absent septum pellucidum (HP:0001331)	1.82001889
89	True hermaphroditism (HP:0010459)	1.81731318
90	Anal atresia (HP:0002023)	1.81680498
91	Gonadal dysgenesis (HP:0000133)	1.79307692
92	Chorioretinal atrophy (HP:0000533)	1.77545887
93	Inability to walk (HP:0002540)	1.77288589
94	Male pseudohermaphroditism (HP:0000037)	1.76455304
95	Polyuria (HP:0000103)	1.76192659
96	Tubular atrophy (HP:0000092)	1.74507804
97	Hypophosphatemic rickets (HP:0004912)	1.73923988
98	Bifid tongue (HP:0010297)	1.73236334
99	Abnormality of the fovea (HP:0000493)	1.72778248
100	Abnormality of glycine metabolism (HP:0010895)	1.72474366

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.66749104
2	BMPR1B	4.54175397
3	TRIM28	3.65093617
4	MST4	2.93663447
5	ERBB4	2.92004840
6	PKN2	2.87871241
7	MAPK15	2.82556090
8	WNK4	2.66298613
9	ZAK	2.58609751
10	TLK1	2.46555232
11	PBK	2.37345280
12	WNK3	2.31367685
13	FRK	2.00255729
14	GRK1	1.96465244
15	TGFBR1	1.93327318
16	TNIK	1.90207777
17	PINK1	1.89161738
18	MATK	1.76281519
19	STK39	1.73815892
20	MUSK	1.67267422
21	NUAK1	1.65242919
22	MAP3K4	1.64815122
23	ADRBK2	1.59702104
24	PRKCI	1.55967334
25	INSRR	1.47736751
26	MAP3K9	1.33914624
27	MAPK13	1.32681342
28	SIK3	1.30707149
29	EPHA2	1.29635843
30	MKNK2	1.25109210
31	BRSK2	1.24347240
32	ADRBK1	1.19796592
33	PLK4	1.11621960
34	MAP4K2	1.09177300
35	WEE1	1.07602579
36	OXSR1	1.02488274
37	STK16	1.02461839
38	TNK2	0.94445601
39	NEK2	0.90163052
40	CDK3	0.87649051
41	CASK	0.87399021
42	NME1	0.85490430
43	MAP2K7	0.83146213
44	VRK1	0.80952424
45	FLT3	0.75180639
46	IRAK2	0.74892679
47	PRKD3	0.70582057
48	PLK1	0.69989010
49	MELK	0.66983593
50	MAPKAPK3	0.65834064
51	NTRK3	0.64066218
52	TRIB3	0.62342715
53	LRRK2	0.61314772
54	TAOK3	0.60431548
55	PNCK	0.60234920
56	ILK	0.59562456
57	CDC7	0.57082400
58	CSNK1G1	0.56822405
59	GRK6	0.54483565
60	BCR	0.53017818
61	EIF2AK3	0.51144821
62	STK10	0.51039604
63	ARAF	0.50659326
64	ERBB2	0.50189491
65	BRSK1	0.49687290
66	VRK2	0.48531779
67	NEK6	0.48429293
68	PRKCQ	0.47648816
69	CHUK	0.47374525
70	ATR	0.46066010
71	CSNK1D	0.45656352
72	BCKDK	0.45463957
73	ERBB3	0.45372384
74	CDK7	0.43798990
75	CSNK1G3	0.42794023
76	MARK3	0.42408055
77	PLK2	0.42334561
78	PLK3	0.42328635
79	CSNK1G2	0.40757090
80	MAP2K1	0.38960320
81	FER	0.38344384
82	AURKA	0.37825502
83	SRPK1	0.36797535
84	CDK18	0.36257468
85	ROCK1	0.34852935
86	CSNK1A1	0.34387955
87	DAPK2	0.33975503
88	PDK2	0.31476117
89	CAMK1D	0.29483637
90	CSNK1A1L	0.29226535
91	NTRK2	0.29035792
92	CSNK1E	0.28053639
93	CAMK1G	0.27454369
94	PRKG1	0.27356640
95	CDK15	0.27326154
96	TTK	0.26942762
97	PRKCE	0.26920268
98	MAP2K6	0.26871766
99	SIK1	0.25863902
100	ATM	0.25228385

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.13641856
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.05057829
3	Basal transcription factors_Homo sapiens_hsa03022	2.83444596
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.75459396
5	Butanoate metabolism_Homo sapiens_hsa00650	2.71075065
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.52158185
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.44553442
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.40179769
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.31956018
10	Homologous recombination_Homo sapiens_hsa03440	2.25019183
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.02360406
12	Sulfur relay system_Homo sapiens_hsa04122	1.99752997
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.97844128
14	ABC transporters_Homo sapiens_hsa02010	1.85533255
15	Protein export_Homo sapiens_hsa03060	1.84059720
16	RNA polymerase_Homo sapiens_hsa03020	1.82298063
17	Proteasome_Homo sapiens_hsa03050	1.71379036
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66238342
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.63427554
20	Propanoate metabolism_Homo sapiens_hsa00640	1.63210158
21	RNA degradation_Homo sapiens_hsa03018	1.63098367
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.52532372
23	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.49131685
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.47487481
25	Olfactory transduction_Homo sapiens_hsa04740	1.45715711
26	Phototransduction_Homo sapiens_hsa04744	1.45466267
27	Caffeine metabolism_Homo sapiens_hsa00232	1.41205097
28	Oxidative phosphorylation_Homo sapiens_hsa00190	1.37922409
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.33172599
30	Peroxisome_Homo sapiens_hsa04146	1.29557144
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.29281181
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26182512
33	Mismatch repair_Homo sapiens_hsa03430	1.23394071
34	Taste transduction_Homo sapiens_hsa04742	1.17547044
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.15756522
36	Base excision repair_Homo sapiens_hsa03410	1.15531645
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.14303523
38	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.14025246
39	Parkinsons disease_Homo sapiens_hsa05012	1.12387493
40	Circadian rhythm_Homo sapiens_hsa04710	1.10369843
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.08424936
42	Nicotine addiction_Homo sapiens_hsa05033	1.08314016
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.07675415
44	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.02389863
45	Huntingtons disease_Homo sapiens_hsa05016	1.02132944
46	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.00181688
47	Nitrogen metabolism_Homo sapiens_hsa00910	1.00083651
48	RNA transport_Homo sapiens_hsa03013	0.99153735
49	Basal cell carcinoma_Homo sapiens_hsa05217	0.98981794
50	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.98530298
51	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.98320782
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.96267681
53	Wnt signaling pathway_Homo sapiens_hsa04310	0.92667258
54	Hippo signaling pathway_Homo sapiens_hsa04390	0.91761692
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86931941
56	Cell cycle_Homo sapiens_hsa04110	0.85756834
57	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.84718710
58	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83608546
59	Purine metabolism_Homo sapiens_hsa00230	0.81798290
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.81760056
61	Fatty acid elongation_Homo sapiens_hsa00062	0.80414985
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.79827830
63	Fatty acid degradation_Homo sapiens_hsa00071	0.78441535
64	Histidine metabolism_Homo sapiens_hsa00340	0.75553329
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74041124
66	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.73567608
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.72200687
68	Metabolic pathways_Homo sapiens_hsa01100	0.71519239
69	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.68264300
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.68115965
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.66791200
72	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66670404
73	Oocyte meiosis_Homo sapiens_hsa04114	0.62682137
74	Linoleic acid metabolism_Homo sapiens_hsa00591	0.62437727
75	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62430080
76	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.62408310
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59235456
78	Lysine degradation_Homo sapiens_hsa00310	0.57178384
79	Selenocompound metabolism_Homo sapiens_hsa00450	0.55190047
80	Retinol metabolism_Homo sapiens_hsa00830	0.54972202
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.54934860
82	Glutathione metabolism_Homo sapiens_hsa00480	0.52875540
83	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.51575756
84	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.51192295
85	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49498765
86	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48127164
87	Regulation of autophagy_Homo sapiens_hsa04140	0.46469888
88	DNA replication_Homo sapiens_hsa03030	0.44414239
89	Ribosome_Homo sapiens_hsa03010	0.44364937
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43922499
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.41442067
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.41058497
93	Alzheimers disease_Homo sapiens_hsa05010	0.39919430
94	Melanogenesis_Homo sapiens_hsa04916	0.39116665
95	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.37913449
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37096166
97	Cocaine addiction_Homo sapiens_hsa05030	0.37086580
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.33313368
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.32624821
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.31762301

SERHL2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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