SERINC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)7.35733570
2hemidesmosome assembly (GO:0031581)7.13612801
3desmosome organization (GO:0002934)6.26874788
4intestinal epithelial cell development (GO:0060576)4.77404071
5hair cycle (GO:0042633)4.70056613
6molting cycle (GO:0042303)4.70056613
7interferon-gamma secretion (GO:0072643)4.51651479
8regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.16044201
9regulation of water loss via skin (GO:0033561)4.03489844
10ventricular cardiac muscle cell action potential (GO:0086005)4.00208629
11calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.99687681
12negative regulation of keratinocyte proliferation (GO:0010839)3.90549684
13intestinal absorption (GO:0050892)3.73427183
14cell adhesion mediated by integrin (GO:0033627)3.72284096
15maintenance of gastrointestinal epithelium (GO:0030277)3.58004186
16epithelial cell-cell adhesion (GO:0090136)3.54512891
17establishment of skin barrier (GO:0061436)3.52831969
18negative regulation of cell fate specification (GO:0009996)3.45324028
19epithelial structure maintenance (GO:0010669)3.44761778
20ectoderm development (GO:0007398)3.42024137
21glial cell proliferation (GO:0014009)3.34759303
22atrioventricular valve morphogenesis (GO:0003181)3.27429307
23gap junction assembly (GO:0016264)3.24182836
24surfactant homeostasis (GO:0043129)3.23791646
25multicellular organismal water homeostasis (GO:0050891)3.21811844
26tight junction assembly (GO:0070830)3.16876561
27endodermal cell differentiation (GO:0035987)3.14665336
28intestinal cholesterol absorption (GO:0030299)3.14140619
29mesodermal cell differentiation (GO:0048333)3.13153227
30branching involved in mammary gland duct morphogenesis (GO:0060444)3.12269928
31hypotonic response (GO:0006971)3.11564516
32dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.11215878
33protein localization to endosome (GO:0036010)3.08935040
34regulation of heart rate by cardiac conduction (GO:0086091)3.08762182
35renal absorption (GO:0070293)3.08444232
36sulfur amino acid catabolic process (GO:0000098)3.07522733
37keratinization (GO:0031424)3.04575496
38hepatocyte apoptotic process (GO:0097284)3.03048991
39intermediate filament organization (GO:0045109)3.01925600
40positive regulation of actin filament depolymerization (GO:0030836)2.99255898
41regulation of cardioblast differentiation (GO:0051890)2.96576593
42peptidyl-glutamic acid carboxylation (GO:0017187)2.95885501
43protein carboxylation (GO:0018214)2.95885501
44basement membrane organization (GO:0071711)2.95061356
45COPI coating of Golgi vesicle (GO:0048205)2.94701731
46Golgi transport vesicle coating (GO:0048200)2.94701731
47lung epithelium development (GO:0060428)2.94567027
48regulation of transforming growth factor beta2 production (GO:0032909)2.93890699
49regulation of cardioblast proliferation (GO:0003264)2.93888095
50regulation of secondary heart field cardioblast proliferation (GO:0003266)2.93888095
51renal system development (GO:0072001)2.92803489
52regulation of apoptotic process involved in morphogenesis (GO:1902337)2.92487977
53regulation of pseudopodium assembly (GO:0031272)2.89788059
54regulation of metalloenzyme activity (GO:0048552)2.89220782
55regulation of skeletal muscle contraction (GO:0014819)2.89077424
56regulation of cell fate specification (GO:0042659)2.88270600
57membrane budding (GO:0006900)2.85742784
58epithelial cell differentiation involved in prostate gland development (GO:0060742)2.83555138
59skin morphogenesis (GO:0043589)2.83453107
60cell-substrate adherens junction assembly (GO:0007045)2.82783107
61focal adhesion assembly (GO:0048041)2.82783107
62retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.82351191
63negative regulation of cell fate commitment (GO:0010454)2.80537519
64digestive system process (GO:0022600)2.80095184
65G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.76958099
66semaphorin-plexin signaling pathway (GO:0071526)2.76391041
67adherens junction assembly (GO:0034333)2.75443324
68urea metabolic process (GO:0019627)2.75124845
69negative regulation of fibrinolysis (GO:0051918)2.74995859
70urea cycle (GO:0000050)2.74914169
71respiratory tube development (GO:0030323)2.74180564
72cell communication involved in cardiac conduction (GO:0086065)2.73939136
73regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.73537125
74positive regulation of epidermal cell differentiation (GO:0045606)2.72963952
75planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72708806
76cell-substrate junction assembly (GO:0007044)2.72693493
77water homeostasis (GO:0030104)2.72313524
78regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70690767
793-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.69214228
80purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.69214228
81regulation of cholesterol biosynthetic process (GO:0045540)2.68594031
82positive regulation of pseudopodium assembly (GO:0031274)2.67893775
83O-glycan processing (GO:0016266)2.67782454
84polarized epithelial cell differentiation (GO:0030859)2.67771100
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.66729831
86keratinocyte differentiation (GO:0030216)2.65913872
87regulation of cholesterol homeostasis (GO:2000188)2.65476522
88keratinocyte development (GO:0003334)2.64134395
89epidermis development (GO:0008544)2.63742817
90lung secretory cell differentiation (GO:0061140)2.63549080
91regulation of plasminogen activation (GO:0010755)2.60779698
92adhesion of symbiont to host (GO:0044406)2.60485230
93negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.60023967
94negative regulation of fatty acid transport (GO:2000192)2.60007941
95regulation of keratinocyte proliferation (GO:0010837)2.59799970
96GDP-mannose metabolic process (GO:0019673)2.59529557
97positive regulation of epidermis development (GO:0045684)2.58893260
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58371212
99proline biosynthetic process (GO:0006561)2.58294413
100adhesion of symbiont to host cell (GO:0044650)2.57017674
101virion attachment to host cell (GO:0019062)2.57017674
102embryonic foregut morphogenesis (GO:0048617)2.56410338
103lung-associated mesenchyme development (GO:0060484)2.55972839
104cellular glucuronidation (GO:0052695)2.55068717
105regulation of early endosome to late endosome transport (GO:2000641)2.54707749
106vitamin A metabolic process (GO:0006776)2.53250180
107galactose catabolic process (GO:0019388)2.53242162
108renal system process involved in regulation of blood volume (GO:0001977)2.52998128
109negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.52187130
110cell junction assembly (GO:0034329)2.52007589
111keratinocyte proliferation (GO:0043616)2.51857189
112positive regulation of Cdc42 GTPase activity (GO:0043089)2.51506773
113cytoskeletal anchoring at plasma membrane (GO:0007016)2.50832189
114protein retention in ER lumen (GO:0006621)2.50713701
115negative regulation of axon extension involved in axon guidance (GO:0048843)2.49929958
116actin filament depolymerization (GO:0030042)2.49461315
117regulation of fibrinolysis (GO:0051917)2.48058090
118positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.47559324
119fibrinolysis (GO:0042730)2.47444181
120uronic acid metabolic process (GO:0006063)2.46188569
121glucuronate metabolic process (GO:0019585)2.46188569
122barbed-end actin filament capping (GO:0051016)2.46011197
123endocytic recycling (GO:0032456)2.45633170
124extracellular matrix disassembly (GO:0022617)2.45355825
125negative regulation of chondrocyte differentiation (GO:0032331)2.45071733
126vitamin transmembrane transport (GO:0035461)2.44908365
127proline metabolic process (GO:0006560)2.44653337
128hormone catabolic process (GO:0042447)2.44469445
129hippo signaling (GO:0035329)2.44246938
130transcytosis (GO:0045056)2.43885439
131regulation of extracellular matrix disassembly (GO:0010715)2.43710785
132lung vasculature development (GO:0060426)2.43475817
133kidney morphogenesis (GO:0060993)2.43046030
134cardiac conduction (GO:0061337)2.42338290
135cell junction organization (GO:0034330)2.40412727
136renal filtration (GO:0097205)2.39386985
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.39292150
138lung lobe morphogenesis (GO:0060463)2.39211216
139regulation of cholesterol metabolic process (GO:0090181)2.38077664
140activation of Rac GTPase activity (GO:0032863)2.37788171
141regulation of proton transport (GO:0010155)2.37618249
1424-hydroxyproline metabolic process (GO:0019471)2.37564543
143nitrogen cycle metabolic process (GO:0071941)2.36495695
144chemical homeostasis within a tissue (GO:0048875)2.35912223
145regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.35845512
146negative regulation of lipase activity (GO:0060192)2.35304923
147glucose 6-phosphate metabolic process (GO:0051156)2.35294845
148very-low-density lipoprotein particle assembly (GO:0034379)2.34030669
149epoxygenase P450 pathway (GO:0019373)2.33403407
150renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.33214729
151type B pancreatic cell proliferation (GO:0044342)2.32774872
152establishment of tissue polarity (GO:0007164)2.32765776
153establishment of planar polarity (GO:0001736)2.32765776
154regulation of hippo signaling (GO:0035330)2.32616692
155regulation of glucose import in response to insulin stimulus (GO:2001273)2.31820434
156collecting duct development (GO:0072044)2.31781449
157diterpenoid biosynthetic process (GO:0016102)2.30833051
158NADH metabolic process (GO:0006734)2.30768512
159positive regulation of gastrulation (GO:2000543)2.30506685
160primary alcohol catabolic process (GO:0034310)2.30474182
161positive regulation of extracellular matrix organization (GO:1903055)2.30008650
162COPII vesicle coating (GO:0048208)2.29782450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.89722260
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.77204287
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.69321426
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.48090666
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.21604476
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.05025107
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.99565942
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.72873623
9ZNF263_19887448_ChIP-Seq_K562_Human2.67993646
10* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.66218607
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.63738620
12* SOX2_20726797_ChIP-Seq_SW620_Human2.21040341
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18587802
14GATA4_25053715_ChIP-Seq_YYC3_Human2.13639565
15CLOCK_20551151_ChIP-Seq_293T_Human2.13603121
16* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11339984
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.09687033
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06496608
19GATA6_25053715_ChIP-Seq_YYC3_Human1.93869186
20RXR_22158963_ChIP-Seq_LIVER_Mouse1.92744640
21ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.90333530
22RACK7_27058665_Chip-Seq_MCF-7_Human1.84418628
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82415778
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69916670
25ATF3_27146783_Chip-Seq_COLON_Human1.68710469
26* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.68604808
27* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.68604808
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67049453
29* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.67025391
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66117805
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.65890792
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63566326
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.55235953
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53933219
35* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53653963
36* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53480286
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.53238090
38* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.52015813
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51648351
40KLF5_25053715_ChIP-Seq_YYC3_Human1.51030354
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50876753
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44537758
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42357429
44* LXR_22292898_ChIP-Seq_THP-1_Human1.35198102
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34488729
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34082896
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34079036
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33948131
49* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32689297
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31986168
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29060786
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28985589
53TP53_22127205_ChIP-Seq_IMR90_Human1.28736837
54GATA3_24758297_ChIP-Seq_MCF-7_Human1.28480132
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28479826
56TP53_20018659_ChIP-ChIP_R1E_Mouse1.26699868
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24781864
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21579380
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21229400
60AHR_22903824_ChIP-Seq_MCF-7_Human1.20169197
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18653485
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15985450
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.15622964
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.14671557
65CJUN_26792858_Chip-Seq_BT549_Human1.14151484
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11754317
67* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10342908
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09823011
69CREB1_26743006_Chip-Seq_LNCaP_Human1.09350258
70ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08596794
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06912260
72* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06542561
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05719021
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04767917
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03464551
76* SMC4_20622854_ChIP-Seq_HELA_Human1.02133210
77* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02109215
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01598117
79BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99323767
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98403982
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96971090
82SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96777396
83TBX20_22080862_ChIP-Seq_HEART_Mouse0.96417627
84TBX20_22328084_ChIP-Seq_HEART_Mouse0.96417627
85* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96298812
86EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96119671
87TCF4_18268006_ChIP-ChIP_LS174T_Human0.96042034
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95442331
89* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94943479
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.94153975
91P68_20966046_ChIP-Seq_HELA_Human0.93850624
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.93425646
93EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93420248
94NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93040919
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91939264
96* UBF1/2_26484160_Chip-Seq_HMECs_Human0.91859967
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91814648
98* TP63_22573176_ChIP-Seq_HFKS_Human0.91477358
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.91367159
100* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89521131
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87660791
102* KDM2B_26808549_Chip-Seq_K562_Human0.86768394
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86147241
104SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86144254
105* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86109190
106CTCF_27219007_Chip-Seq_Bcells_Human0.85119354
107ELK3_25401928_ChIP-Seq_HUVEC_Human0.84770006
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84078625
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82409382
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82094098
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.79910783
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.78686934
113FOXA2_19822575_ChIP-Seq_HepG2_Human0.77578837
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.77322630
115SA1_27219007_Chip-Seq_ERYTHROID_Human0.76320440
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75385380
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.73825017
118ISL1_27105846_Chip-Seq_CPCs_Mouse0.73420673
119* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.73294482
120TP53_18474530_ChIP-ChIP_U2OS_Human0.73082748
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72705736
122* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72581174
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71836074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.77358857
2MP0000537_abnormal_urethra_morphology3.68739220
3MP0004264_abnormal_extraembryonic_tissu3.18884519
4MP0002796_impaired_skin_barrier2.89580662
5MP0008004_abnormal_stomach_pH2.82495243
6MP0010030_abnormal_orbit_morphology2.81494184
7MP0003705_abnormal_hypodermis_morpholog2.69605058
8MP0002098_abnormal_vibrissa_morphology2.64501869
9MP0000579_abnormal_nail_morphology2.61086541
10MP0001666_abnormal_nutrient_absorption2.53593000
11MP0008438_abnormal_cutaneous_collagen2.45014742
12MP0000566_synostosis2.39072818
13MP0001849_ear_inflammation2.36583736
14MP0010678_abnormal_skin_adnexa2.32689611
15MP0005275_abnormal_skin_tensile2.27015296
16MP0008789_abnormal_olfactory_epithelium2.23418931
17MP0009053_abnormal_anal_canal2.21455392
18MP0005257_abnormal_intraocular_pressure2.21072391
19MP0002254_reproductive_system_inflammat2.16038035
20MP0005409_darkened_coat_color2.13849322
21MP0005360_urolithiasis2.05329888
22MP0005451_abnormal_body_composition2.03880557
23MP0000762_abnormal_tongue_morphology1.96964250
24MP0002139_abnormal_hepatobiliary_system1.96028620
25MP0000462_abnormal_digestive_system1.90283646
26MP0005501_abnormal_skin_physiology1.89001113
27MP0010352_gastrointestinal_tract_polyps1.79602682
28MP0002234_abnormal_pharynx_morphology1.78632409
29MP0003191_abnormal_cellular_cholesterol1.75907128
30MP0003453_abnormal_keratinocyte_physiol1.74207617
31MP0002060_abnormal_skin_morphology1.71026391
32MP0000383_abnormal_hair_follicle1.70328021
33MP0001216_abnormal_epidermal_layer1.63135091
34MP0005085_abnormal_gallbladder_physiolo1.61915895
35MP0000538_abnormal_urinary_bladder1.60881167
36MP0001664_abnormal_digestion1.59260975
37MP0000647_abnormal_sebaceous_gland1.56305692
38MP0000377_abnormal_hair_follicle1.54719154
39MP0001873_stomach_inflammation1.53748367
40MP0003300_gastrointestinal_ulcer1.53436975
41MP0000467_abnormal_esophagus_morphology1.52126442
42MP0003878_abnormal_ear_physiology1.50397429
43MP0005377_hearing/vestibular/ear_phenot1.50397429
44MP0005058_abnormal_lysosome_morphology1.49825559
45MP0004019_abnormal_vitamin_homeostasis1.48343257
46MP0005394_taste/olfaction_phenotype1.46525997
47MP0005499_abnormal_olfactory_system1.46525997
48MP0005248_abnormal_Harderian_gland1.44815489
49MP0003806_abnormal_nucleotide_metabolis1.41288819
50MP0003566_abnormal_cell_adhesion1.36859399
51MP0009780_abnormal_chondrocyte_physiolo1.36715560
52MP0001346_abnormal_lacrimal_gland1.35151533
53MP0008875_abnormal_xenobiotic_pharmacok1.34576850
54MP0003941_abnormal_skin_development1.32927779
55MP0008260_abnormal_autophagy1.29722673
56MP0010771_integument_phenotype1.29396368
57MP0000427_abnormal_hair_cycle1.28692387
58MP0001958_emphysema1.25148329
59MP0000534_abnormal_ureter_morphology1.23228524
60MP0002089_abnormal_postnatal_growth/wei1.22523276
61MP0005365_abnormal_bile_salt1.21913908
62MP0004272_abnormal_basement_membrane1.21790910
63MP0001663_abnormal_digestive_system1.18376825
64MP0002233_abnormal_nose_morphology1.18179424
65MP0005381_digestive/alimentary_phenotyp1.18139330
66MP0003091_abnormal_cell_migration1.17269924
67MP0005367_renal/urinary_system_phenotyp1.16888181
68MP0000516_abnormal_urinary_system1.16888181
69MP0000858_altered_metastatic_potential1.15250026
70MP0000733_abnormal_muscle_development1.15081895
71MP0000477_abnormal_intestine_morphology1.14057735
72MP0004858_abnormal_nervous_system1.09865787
73MP0003315_abnormal_perineum_morphology1.07663846
74MP0003866_abnormal_defecation1.07006474
75MP0009384_cardiac_valve_regurgitation1.02999306
76MP0005083_abnormal_biliary_tract1.02402246
77MP0003252_abnormal_bile_duct1.00784397
78MP0000003_abnormal_adipose_tissue1.00297377
79MP0009840_abnormal_foam_cell0.99242786
80MP0000678_abnormal_parathyroid_gland0.99194105
81MP0000049_abnormal_middle_ear0.98911402
82MP0005023_abnormal_wound_healing0.96970710
83MP0002896_abnormal_bone_mineralization0.96340269
84MP0003115_abnormal_respiratory_system0.95807963
85MP0009250_abnormal_appendicular_skeleto0.94716155
86MP0005076_abnormal_cell_differentiation0.94331335
87MP0000490_abnormal_crypts_of0.93766575
88MP0000013_abnormal_adipose_tissue0.91526222
89MP0003950_abnormal_plasma_membrane0.91139970
90MP0000470_abnormal_stomach_morphology0.90722578
91MP0002249_abnormal_larynx_morphology0.90518839
92MP0003942_abnormal_urinary_system0.89900136
93MP0000627_abnormal_mammary_gland0.88892067
94MP0002282_abnormal_trachea_morphology0.88487803
95MP0009643_abnormal_urine_homeostasis0.88343454
96MP0002138_abnormal_hepatobiliary_system0.87600308
97MP0000613_abnormal_salivary_gland0.87414942
98MP0003279_aneurysm0.87162417
99MP0004782_abnormal_surfactant_physiolog0.85307822
100MP0010329_abnormal_lipoprotein_level0.85302864
101MP0003119_abnormal_digestive_system0.85042320
102MP0010368_abnormal_lymphatic_system0.84824647
103MP0003755_abnormal_palate_morphology0.84661375
104MP0010155_abnormal_intestine_physiology0.84239296
105MP0005187_abnormal_penis_morphology0.82849139
106MP0003329_amyloid_beta_deposits0.82327781
107MP0001270_distended_abdomen0.80742787
108MP0003183_abnormal_peptide_metabolism0.79984600
109MP0003385_abnormal_body_wall0.78344874
110MP0004885_abnormal_endolymph0.76732074
111MP0002653_abnormal_ependyma_morphology0.75852086
112MP0000751_myopathy0.75720312
113MP0005508_abnormal_skeleton_morphology0.75432482
114MP0004947_skin_inflammation0.74968000
115MP0001881_abnormal_mammary_gland0.73953132
116MP0005623_abnormal_meninges_morphology0.73552931
117MP0003937_abnormal_limbs/digits/tail_de0.72487124
118MP0001756_abnormal_urination0.72443499
119MP0000767_abnormal_smooth_muscle0.72286207
120MP0000163_abnormal_cartilage_morphology0.72251547
121MP0002932_abnormal_joint_morphology0.71546328
122MP0001765_abnormal_ion_homeostasis0.69435231
123MP0001243_abnormal_dermal_layer0.69414536
124MP0005375_adipose_tissue_phenotype0.68889697
125MP0002877_abnormal_melanocyte_morpholog0.68593113
126MP0009931_abnormal_skin_appearance0.67789607
127MP0006054_spinal_hemorrhage0.67623293
128MP0005164_abnormal_response_to0.66249820
129MP0005636_abnormal_mineral_homeostasis0.65688211
130MP0003868_abnormal_feces_composition0.65501200
131MP0000367_abnormal_coat/_hair0.65414150
132MP0005670_abnormal_white_adipose0.60140004
133MP0001542_abnormal_bone_strength0.59137512
134MP0005503_abnormal_tendon_morphology0.58041765
135MP0004233_abnormal_muscle_weight0.57897599
136MP0005332_abnormal_amino_acid0.55467033
137MP0001661_extended_life_span0.54771541

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.71063425
2Onycholysis (HP:0001806)5.81455764
3Fragile nails (HP:0001808)5.18664679
4Milia (HP:0001056)4.89367860
5Pili torti (HP:0003777)4.85501293
6Atrophic scars (HP:0001075)4.40237685
7Woolly hair (HP:0002224)4.27971243
8Myopathic facies (HP:0002058)4.01085802
9Plantar hyperkeratosis (HP:0007556)3.85036266
10Premature rupture of membranes (HP:0001788)3.58039217
11Ileus (HP:0002595)3.56052470
12Thick nail (HP:0001805)3.49036561
13Protrusio acetabuli (HP:0003179)3.37781958
14Alopecia of scalp (HP:0002293)3.28837060
15Distal arthrogryposis (HP:0005684)3.25631613
16Curly hair (HP:0002212)3.21656459
17Absent phalangeal crease (HP:0006109)3.18556865
18Nail dystrophy (HP:0008404)3.17910932
19Muscle fiber inclusion bodies (HP:0100299)3.17118974
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.16314849
21Deep venous thrombosis (HP:0002625)3.09035856
22Cervical subluxation (HP:0003308)3.05468929
23Nemaline bodies (HP:0003798)3.01598575
24Gout (HP:0001997)2.81590567
25Hypotrichosis (HP:0001006)2.81465263
26Abnormal hair laboratory examination (HP:0003328)2.80076909
27Malnutrition (HP:0004395)2.74706315
28Type 1 muscle fiber predominance (HP:0003803)2.74005033
29Abnormal finger flexion creases (HP:0006143)2.67574604
30Distal upper limb amyotrophy (HP:0007149)2.62733116
31Upper limb amyotrophy (HP:0009129)2.62733116
32Pterygium (HP:0001059)2.57076040
33Fragile skin (HP:0001030)2.53338569
34Rectal prolapse (HP:0002035)2.53302649
35Micronodular cirrhosis (HP:0001413)2.52943316
36Vascular tortuosity (HP:0004948)2.50301846
37Hyperactive renin-angiotensin system (HP:0000841)2.49617246
38Ulnar deviation of the wrist (HP:0003049)2.47831108
39Thin bony cortex (HP:0002753)2.45688117
40Arterial tortuosity (HP:0005116)2.44476662
41Vertebral compression fractures (HP:0002953)2.43905759
42Hypoplasia of dental enamel (HP:0006297)2.42870952
43Abnormality of chloride homeostasis (HP:0011422)2.40509448
44Abnormal blistering of the skin (HP:0008066)2.40421361
45Short nail (HP:0001799)2.35786440
46Round ear (HP:0100830)2.33689181
47Abnormality of carpal bone ossification (HP:0006257)2.33469547
48Abnormality of nail color (HP:0100643)2.32792984
49Amniotic constriction ring (HP:0009775)2.32528846
50Abnormality of placental membranes (HP:0011409)2.32528846
51Abnormality of the gastric mucosa (HP:0004295)2.32123270
52Trismus (HP:0000211)2.29913054
53Mildly elevated creatine phosphokinase (HP:0008180)2.28414350
54Advanced eruption of teeth (HP:0006288)2.28406067
55Abnormality of the Achilles tendon (HP:0005109)2.28233629
56Popliteal pterygium (HP:0009756)2.28047523
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26063432
58Flat acetabular roof (HP:0003180)2.25943559
59Palpitations (HP:0001962)2.25844509
60Abdominal distention (HP:0003270)2.25573873
61Distal lower limb amyotrophy (HP:0008944)2.25282318
62Ventricular fibrillation (HP:0001663)2.24362384
63Palmoplantar hyperkeratosis (HP:0000972)2.22926112
64Achilles tendon contracture (HP:0001771)2.21801317
65Calcaneovalgus deformity (HP:0001848)2.21105846
66Deformed tarsal bones (HP:0008119)2.20022765
67Broad face (HP:0000283)2.19312687
68Abnormality of the distal phalanges of the toes (HP:0010182)2.17363345
69Tarsal synostosis (HP:0008368)2.16053075
70Hydroxyprolinuria (HP:0003080)2.15559866
71Abnormality of proline metabolism (HP:0010907)2.15559866
72Increased purine levels (HP:0004368)2.09635004
73Hyperuricemia (HP:0002149)2.09635004
74Palmar hyperkeratosis (HP:0010765)2.07131722
75Aplasia cutis congenita (HP:0001057)2.06678387
76Neonatal death (HP:0003811)2.05848158
77Neonatal short-limb short stature (HP:0008921)2.05532903
78Hemorrhage of the eye (HP:0011885)2.05408813
79Esophageal varix (HP:0002040)2.02481879
80Glomerulosclerosis (HP:0000096)2.02240259
81Symphalangism affecting the phalanges of the hand (HP:0009773)2.02138568
82Axonal loss (HP:0003447)2.01367893
83Selective tooth agenesis (HP:0001592)2.01324876
84Ventricular tachycardia (HP:0004756)2.01238783
85Ureteral stenosis (HP:0000071)2.00895147
86Follicular hyperkeratosis (HP:0007502)1.99932949
87Ureteral obstruction (HP:0006000)1.99334273
88Hand muscle atrophy (HP:0009130)1.98488794
89Fatigable weakness (HP:0003473)1.97108528
90Abnormality of the neuromuscular junction (HP:0003398)1.97108528
91Xanthomatosis (HP:0000991)1.96174706
92Abnormality of purine metabolism (HP:0004352)1.96061361
93Dehydration (HP:0001944)1.95523592
94Pustule (HP:0200039)1.95501698
95Abnormal ossification of hand bones (HP:0005921)1.93425189
96Acanthosis nigricans (HP:0000956)1.93337431
97Increased connective tissue (HP:0009025)1.92156468
98Difficulty climbing stairs (HP:0003551)1.91278744
99Synostosis involving bones of the lower limbs (HP:0009138)1.91127730
100Synostosis involving bones of the feet (HP:0009140)1.91127730
101Vascular calcification (HP:0004934)1.91010448
102Spinal rigidity (HP:0003306)1.89912643
103Ridged nail (HP:0001807)1.87920008
104Abnormality of complement system (HP:0005339)1.86635332
105Bronchomalacia (HP:0002780)1.85873325
106Hypoplastic labia majora (HP:0000059)1.85584245
107Ankle contracture (HP:0006466)1.85557949
108Esophageal atresia (HP:0002032)1.85423158
109Unilateral renal agenesis (HP:0000122)1.85063860
110Bladder diverticulum (HP:0000015)1.84863295
111Aortic dissection (HP:0002647)1.84722082
112Focal segmental glomerulosclerosis (HP:0000097)1.83710363
113Blue sclerae (HP:0000592)1.83565721
114Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82369668
115Systemic lupus erythematosus (HP:0002725)1.82316328
116Mitral stenosis (HP:0001718)1.82015848
117Distal lower limb muscle weakness (HP:0009053)1.80898229
118Sparse eyelashes (HP:0000653)1.80898063
119Exercise-induced myalgia (HP:0003738)1.80600441
120Abnormality of the labia majora (HP:0012881)1.79565965
121Wormian bones (HP:0002645)1.78364959
122Cardiovascular calcification (HP:0011915)1.77125185
123Abnormality of the middle phalanges of the toes (HP:0010183)1.76948808
124Abnormality of the aortic arch (HP:0012303)1.76499720
125Abnormality of the acetabulum (HP:0003170)1.76494669
126Elbow flexion contracture (HP:0002987)1.76136327
127Ulnar bowing (HP:0003031)1.75414681
128Cerebral aneurysm (HP:0004944)1.74118864
129Ankyloglossia (HP:0010296)1.73183149
130Aortic aneurysm (HP:0004942)1.71963495
131Intrahepatic cholestasis (HP:0001406)1.70099206
132Biliary tract neoplasm (HP:0100574)1.69312990
133Complement deficiency (HP:0004431)1.69135618
134Down-sloping shoulders (HP:0200021)1.67427585
135Coxa vara (HP:0002812)1.67124969
136Abnormality of cochlea (HP:0000375)1.67020045
137Interstitial pulmonary disease (HP:0006530)1.66839951
138Lip pit (HP:0100267)1.66507376
139Conjugated hyperbilirubinemia (HP:0002908)1.65879168
140Tibial bowing (HP:0002982)1.65083577
141Abnormal pancreas size (HP:0012094)1.64631333
142Back pain (HP:0003418)1.64628454
143Shallow orbits (HP:0000586)1.64557060
144Urinary glycosaminoglycan excretion (HP:0003541)1.64222359
145Mucopolysacchariduria (HP:0008155)1.64222359
146Ulnar deviation of finger (HP:0009465)1.63792013
147Sparse scalp hair (HP:0002209)1.63596125
148Hyperparathyroidism (HP:0000843)1.63435672
149Abnormality of the calcaneus (HP:0008364)1.61054107
150Natal tooth (HP:0000695)1.60934935
151Hyperphosphatemia (HP:0002905)1.60620860
152Limb-girdle muscle atrophy (HP:0003797)1.58687361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.97458659
2EPHB23.64064550
3MST1R3.47095425
4LMTK22.97882437
5MAP2K22.94090091
6FER2.63078784
7TRIB32.50935692
8NME12.31407108
9FRK2.31012480
10MST42.26884614
11MAP3K22.16015264
12ARAF2.12627009
13LATS12.04501321
14EPHA32.03224358
15IRAK31.99257455
16ERN11.95509211
17PIK3CA1.92436944
18NTRK11.88915508
19PTK61.84105442
20RIPK11.83442042
21PTK21.79514335
22TESK11.73844487
23RPS6KB21.73316314
24SMG11.67396053
25MAPKAPK31.64616281
26MAP2K11.62223592
27PAK41.61701394
28ICK1.57811019
29DDR21.51865103
30MAP3K31.49956476
31SIK11.49206911
32MET1.48014924
33ERBB21.40187728
34TTN1.37716120
35ERBB31.35731312
36STK38L1.32209161
37MAP2K61.29878863
38NME21.28077898
39EPHB11.23056106
40PIK3CG1.15884000
41PRKG21.14614289
42PRKD21.10458095
43ERBB41.09506375
44FGFR41.06276332
45LIMK11.03059150
46FLT31.02417651
47PKN21.02354876
48CDC42BPA1.00945335
49CDK120.99492068
50PDGFRA0.96095517
51BCKDK0.90929918
52LRRK20.88517356
53MAPK150.88251393
54PAK30.87743706
55PRKCI0.86513928
56MATK0.85303486
57STK380.84587280
58ABL20.84016795
59MYLK0.83836573
60DYRK1B0.83448804
61TAOK10.83291908
62RPS6KA40.81887620
63TAOK20.81417567
64PHKG10.79614272
65PHKG20.79614272
66MAP3K100.79484290
67STK240.77820911
68MAP3K90.77818787
69TGFBR20.76658908
70MUSK0.76356951
71KSR20.75729868
72MAP3K120.73733681
73MAP3K60.73472554
74FGFR10.70556181
75MAP3K110.69737660
76BCR0.69104731
77NUAK10.62221639
78OBSCN0.61704745
79BRAF0.61251377
80LATS20.59381515
81TESK20.59337478
82PRPF4B0.58659877
83MAP3K70.58054737
84EEF2K0.57716389
85KSR10.54348199
86MAP3K80.53205243
87PIM20.52570343
88ROCK10.51278310
89MOS0.51266527
90CAMK1D0.51025846
91CAMK2G0.50933764
92TBK10.50475183
93MAP3K10.49404188
94ILK0.47629003
95WNK40.47508199
96CDK60.47462985
97PRKD30.46921203
98SIK30.45604443
99RPS6KL10.43572343
100RPS6KC10.43572343
101PDPK10.43478888
102ZAP700.41148108
103DAPK20.40695252
104RPS6KA20.40560348
105MARK20.38009328
106MAP2K30.37755246
107TRPM70.37339157
108RPS6KA10.36489138
109NEK10.35847636
110DYRK30.34576726
111CAMK2D0.33993922
112BMX0.33190306
113PAK20.33154268
114ROCK20.33096419
115CDK90.32373268
116MAPKAPK20.32302593
117AKT30.31582526
118DMPK0.30784494
119MTOR0.30666268
120CHUK0.30470675
121DAPK30.27925082
122RET0.26741488
123RPS6KA60.25496896
124CAMK2B0.24669614
125NEK90.24535943
126TGFBR10.24309566
127GSK3A0.22787977
128AKT20.22740385
129PRKD10.22333744
130PRKCZ0.21947667
131CAMK1G0.21674121
132STK390.20804501
133PDGFRB0.20131510
134SRC0.19447005

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.04726648
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.77685151
3Fat digestion and absorption_Homo sapiens_hsa049752.72227094
4Mineral absorption_Homo sapiens_hsa049782.38751318
5Tight junction_Homo sapiens_hsa045302.10356935
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.08316084
7Bladder cancer_Homo sapiens_hsa052192.04719865
8Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99845517
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.95573054
10Other glycan degradation_Homo sapiens_hsa005111.91976179
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.85646958
12Glutathione metabolism_Homo sapiens_hsa004801.79967378
13Complement and coagulation cascades_Homo sapiens_hsa046101.77597386
14Adherens junction_Homo sapiens_hsa045201.74482276
15Chemical carcinogenesis_Homo sapiens_hsa052041.73595497
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.69710048
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68459146
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.61787482
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.60476045
20Basal cell carcinoma_Homo sapiens_hsa052171.59585318
21Fatty acid degradation_Homo sapiens_hsa000711.57575219
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56415147
23Histidine metabolism_Homo sapiens_hsa003401.54353150
24Hippo signaling pathway_Homo sapiens_hsa043901.53683708
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53549705
26Starch and sucrose metabolism_Homo sapiens_hsa005001.51263565
27Bile secretion_Homo sapiens_hsa049761.47155991
28Renin-angiotensin system_Homo sapiens_hsa046141.43810246
29Tyrosine metabolism_Homo sapiens_hsa003501.39257995
30Galactose metabolism_Homo sapiens_hsa000521.39007113
31Vitamin digestion and absorption_Homo sapiens_hsa049771.35101156
32Protein digestion and absorption_Homo sapiens_hsa049741.32192299
33ECM-receptor interaction_Homo sapiens_hsa045121.32184607
34Thyroid cancer_Homo sapiens_hsa052161.26866846
35Tryptophan metabolism_Homo sapiens_hsa003801.25072250
36Fructose and mannose metabolism_Homo sapiens_hsa000511.23964562
37Folate biosynthesis_Homo sapiens_hsa007901.15578664
38Fatty acid biosynthesis_Homo sapiens_hsa000611.14003161
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11474011
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10467055
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09405207
42Biosynthesis of amino acids_Homo sapiens_hsa012301.08974551
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.08748011
44Proteoglycans in cancer_Homo sapiens_hsa052051.05577320
45Caffeine metabolism_Homo sapiens_hsa002321.05005812
46Prion diseases_Homo sapiens_hsa050201.04447789
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.04191958
48Vibrio cholerae infection_Homo sapiens_hsa051101.03425288
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01849231
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01540688
51Retinol metabolism_Homo sapiens_hsa008301.00175977
52Sphingolipid metabolism_Homo sapiens_hsa006000.99537699
53Hedgehog signaling pathway_Homo sapiens_hsa043400.97498614
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97433875
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97332664
56Endometrial cancer_Homo sapiens_hsa052130.96546919
57Butanoate metabolism_Homo sapiens_hsa006500.95915690
58PPAR signaling pathway_Homo sapiens_hsa033200.94589940
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94069946
60Pyruvate metabolism_Homo sapiens_hsa006200.93320336
61Small cell lung cancer_Homo sapiens_hsa052220.93289734
62beta-Alanine metabolism_Homo sapiens_hsa004100.93073636
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91405059
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89110980
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88812689
66Focal adhesion_Homo sapiens_hsa045100.88236362
67Glycerolipid metabolism_Homo sapiens_hsa005610.86125994
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86106788
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84252251
70Pancreatic secretion_Homo sapiens_hsa049720.83224256
71Sulfur relay system_Homo sapiens_hsa041220.82868742
72Lysosome_Homo sapiens_hsa041420.82817714
73Steroid biosynthesis_Homo sapiens_hsa001000.82174057
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79734898
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.78322631
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.77409398
77Arginine and proline metabolism_Homo sapiens_hsa003300.76923984
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.76101340
79N-Glycan biosynthesis_Homo sapiens_hsa005100.74696893
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74430119
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73064488
82Thyroid hormone synthesis_Homo sapiens_hsa049180.73041247
83Fatty acid metabolism_Homo sapiens_hsa012120.71837233
84Carbon metabolism_Homo sapiens_hsa012000.71804075
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69759105
86Amoebiasis_Homo sapiens_hsa051460.69073561
87Pentose phosphate pathway_Homo sapiens_hsa000300.68391773
88Gastric acid secretion_Homo sapiens_hsa049710.67220303
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66190820
90Peroxisome_Homo sapiens_hsa041460.64627043
91Arginine biosynthesis_Homo sapiens_hsa002200.64361607
92Hepatitis C_Homo sapiens_hsa051600.62309793
93Insulin resistance_Homo sapiens_hsa049310.61356894
94Axon guidance_Homo sapiens_hsa043600.60710314
95TGF-beta signaling pathway_Homo sapiens_hsa043500.59932102
96AMPK signaling pathway_Homo sapiens_hsa041520.58911083
97Phenylalanine metabolism_Homo sapiens_hsa003600.58876855
98Propanoate metabolism_Homo sapiens_hsa006400.57668483
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56743023
100Shigellosis_Homo sapiens_hsa051310.54915422
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.54289547
102Arachidonic acid metabolism_Homo sapiens_hsa005900.54171238
103Melanogenesis_Homo sapiens_hsa049160.54004558
104Linoleic acid metabolism_Homo sapiens_hsa005910.53016160
105Fatty acid elongation_Homo sapiens_hsa000620.52534545
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48127243
107Chronic myeloid leukemia_Homo sapiens_hsa052200.47327844
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44766765
109Dilated cardiomyopathy_Homo sapiens_hsa054140.44565841
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44536507
111Notch signaling pathway_Homo sapiens_hsa043300.43036580
112Insulin signaling pathway_Homo sapiens_hsa049100.42754604
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42230454
114Endocytosis_Homo sapiens_hsa041440.42158184
115Salmonella infection_Homo sapiens_hsa051320.41867531
116Toxoplasmosis_Homo sapiens_hsa051450.41830168
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.41117004
118Glucagon signaling pathway_Homo sapiens_hsa049220.41020551
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40838634
120ErbB signaling pathway_Homo sapiens_hsa040120.40773982
121Prostate cancer_Homo sapiens_hsa052150.40664021
122MicroRNAs in cancer_Homo sapiens_hsa052060.40229745
123VEGF signaling pathway_Homo sapiens_hsa043700.39699898
124Collecting duct acid secretion_Homo sapiens_hsa049660.39257668
125Pertussis_Homo sapiens_hsa051330.37028752
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36948631

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