SERINC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.49819958
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.49819958
3antigen processing and presentation of endogenous antigen (GO:0019883)5.99198777
4positive regulation of B cell differentiation (GO:0045579)5.77732307
5positive regulation of gamma-delta T cell activation (GO:0046645)5.70757029
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.69300179
7B cell receptor signaling pathway (GO:0050853)5.39177524
8regulation of gamma-delta T cell differentiation (GO:0045586)4.76572332
9Golgi transport vesicle coating (GO:0048200)4.69944297
10COPI coating of Golgi vesicle (GO:0048205)4.69944297
11regulation of interferon-beta biosynthetic process (GO:0045357)4.69846023
12regulation of B cell differentiation (GO:0045577)4.37930623
13germ cell migration (GO:0008354)4.27984515
14regulation of gamma-delta T cell activation (GO:0046643)4.19014608
15cell adhesion mediated by integrin (GO:0033627)4.06689357
16regulation of B cell receptor signaling pathway (GO:0050855)4.05147004
17protein localization to endosome (GO:0036010)3.98487528
18negative regulation of granulocyte differentiation (GO:0030853)3.98451101
19antigen processing and presentation via MHC class Ib (GO:0002475)3.97906009
20macrophage activation involved in immune response (GO:0002281)3.93060036
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.91573415
22modulation by symbiont of host immune response (GO:0052553)3.91573415
23positive regulation by symbiont of host defense response (GO:0052509)3.91573415
24modulation by symbiont of host defense response (GO:0052031)3.91573415
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.91573415
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.91573415
27definitive hemopoiesis (GO:0060216)3.89734831
28natural killer cell differentiation (GO:0001779)3.89263038
29positive regulation of histone deacetylation (GO:0031065)3.80852620
30skin morphogenesis (GO:0043589)3.80404211
31cellular extravasation (GO:0045123)3.77907700
32negative regulation of phagocytosis (GO:0050765)3.76786688
33hepatocyte apoptotic process (GO:0097284)3.63792179
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.60232639
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.50582748
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.48777557
37negative regulation of B cell proliferation (GO:0030889)3.47632415
38mannose metabolic process (GO:0006013)3.45482249
39negative regulation of erythrocyte differentiation (GO:0045647)3.44471323
40protein retention in ER lumen (GO:0006621)3.39144354
41regulation of integrin-mediated signaling pathway (GO:2001044)3.34341751
42desmosome organization (GO:0002934)3.29317704
43tolerance induction (GO:0002507)3.27201193
44COPII vesicle coating (GO:0048208)3.24438565
45glutamate secretion (GO:0014047)3.23117756
46negative regulation of bone resorption (GO:0045779)3.22288316
47vesicle coating (GO:0006901)3.17607559
48T cell homeostasis (GO:0043029)3.16324976
49pinocytosis (GO:0006907)3.11903474
50positive regulation of lamellipodium assembly (GO:0010592)3.08561024
51mesodermal cell differentiation (GO:0048333)3.08344629
52Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05674915
53positive regulation of interferon-alpha production (GO:0032727)3.05416750
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.03829292
55lymphocyte homeostasis (GO:0002260)3.01148686
56JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00761993
57regulation of interferon-alpha production (GO:0032647)3.00414445
58negative regulation of complement activation (GO:0045916)3.00316179
59negative regulation of protein localization to plasma membrane (GO:1903077)2.99220958
60positive regulation of receptor recycling (GO:0001921)2.96252520
61positive regulation of protein deacetylation (GO:0090312)2.94084445
62regulation of granulocyte differentiation (GO:0030852)2.93903268
63angiogenesis involved in wound healing (GO:0060055)2.93655582
64embryonic hemopoiesis (GO:0035162)2.93039319
65regulation of erythrocyte differentiation (GO:0045646)2.92302451
66B cell homeostasis (GO:0001782)2.92101324
67negative regulation of protein activation cascade (GO:2000258)2.91455882
68retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91143154
69macroautophagy (GO:0016236)2.89608131
70sequestering of extracellular ligand from receptor (GO:0035581)2.89568239
71megakaryocyte development (GO:0035855)2.89015571
72regulation of interleukin-12 biosynthetic process (GO:0045075)2.87771858
73negative regulation of cell killing (GO:0031342)2.86734260
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86734260
75neutrophil activation involved in immune response (GO:0002283)2.86072830
76immunoglobulin mediated immune response (GO:0016064)2.85713463
77hemidesmosome assembly (GO:0031581)2.84660929
78cellular copper ion homeostasis (GO:0006878)2.83119706
79iron ion import (GO:0097286)2.82346808
80platelet degranulation (GO:0002576)2.81426151
81protein maturation by protein folding (GO:0022417)2.79193595
82regulation of metalloenzyme activity (GO:0048552)2.77837223
83synaptic vesicle maturation (GO:0016188)2.76938558
84response to laminar fluid shear stress (GO:0034616)2.76876589
85microglial cell activation (GO:0001774)2.76252378
86cellular response to zinc ion (GO:0071294)2.74522169
87neutrophil activation (GO:0042119)2.73355592
88mucosal-associated lymphoid tissue development (GO:0048537)2.73298195
89Peyers patch development (GO:0048541)2.73298195
90mature B cell differentiation (GO:0002335)2.72993973
91barbed-end actin filament capping (GO:0051016)2.71565756
92leukocyte homeostasis (GO:0001776)2.71545269
93myeloid cell activation involved in immune response (GO:0002275)2.66871102
94positive regulation of lamellipodium organization (GO:1902745)2.66855253
95response to interleukin-15 (GO:0070672)2.66093037
96cortical actin cytoskeleton organization (GO:0030866)2.64591151
97membrane raft organization (GO:0031579)2.63911784
98response to host (GO:0075136)2.63607391
99response to host defenses (GO:0052200)2.63607391
100response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63607391
101extracellular fibril organization (GO:0043206)2.62750361
102substrate-dependent cell migration (GO:0006929)2.62678888
103positive regulation of chemokine secretion (GO:0090197)2.62001719
104positive regulation of erythrocyte differentiation (GO:0045648)2.61199084
105positive regulation of actin filament depolymerization (GO:0030836)2.60191441
106antigen receptor-mediated signaling pathway (GO:0050851)2.58256512
107cellular potassium ion homeostasis (GO:0030007)2.57354075
108cellular hyperosmotic response (GO:0071474)2.56816350
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.55946853
110regulation of B cell proliferation (GO:0030888)2.54838178
111positive regulation of Rap GTPase activity (GO:0032854)2.54564686
112B cell proliferation (GO:0042100)2.53990260
113protein hydroxylation (GO:0018126)2.53625505
114response to host immune response (GO:0052572)2.53536490
115response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.53536490
116regulation of superoxide anion generation (GO:0032928)2.52372789
117negative regulation of stress fiber assembly (GO:0051497)2.51426496
118lymph vessel development (GO:0001945)2.48902302
119regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48624397
120regulation of receptor recycling (GO:0001919)2.48346648
121fibrinolysis (GO:0042730)2.48150239
122basement membrane organization (GO:0071711)2.47952247
123macrophage activation (GO:0042116)2.47884141
124negative regulation of bone remodeling (GO:0046851)2.47607355
125erythrocyte maturation (GO:0043249)2.47309317
126peptidyl-proline hydroxylation (GO:0019511)2.47299863
127positive regulation of granulocyte differentiation (GO:0030854)2.46936744
128positive regulation of macrophage differentiation (GO:0045651)2.46491656
129regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.45647632
130macrophage differentiation (GO:0030225)2.45488554
131granulocyte activation (GO:0036230)2.45472637
132positive regulation of blood coagulation (GO:0030194)2.44993268
133positive regulation of hemostasis (GO:1900048)2.44993268
134sodium ion export (GO:0071436)2.44675971
135actin filament depolymerization (GO:0030042)2.44534004
136fibril organization (GO:0097435)2.43372125
137germinal center formation (GO:0002467)2.43059900
138cell-substrate junction assembly (GO:0007044)2.42819293
139mature B cell differentiation involved in immune response (GO:0002313)2.42622247
140regulation of phagocytosis (GO:0050764)2.42253960
141import into cell (GO:0098657)2.42090160
142positive thymic T cell selection (GO:0045059)2.41851653
143adaptation of signaling pathway (GO:0023058)2.41486256
144regulation of transforming growth factor beta1 production (GO:0032908)2.41354955
145lymph node development (GO:0048535)2.41099623
146response to protozoan (GO:0001562)2.40708806
147negative regulation of interleukin-6 production (GO:0032715)2.40656570
148hypotonic response (GO:0006971)2.39734199
149Golgi to plasma membrane protein transport (GO:0043001)2.39588721
150regulation of amyloid precursor protein catabolic process (GO:1902991)2.39128981
151mast cell activation (GO:0045576)2.38675739
152type B pancreatic cell proliferation (GO:0044342)2.38384070
153positive regulation of coagulation (GO:0050820)2.38072464
154regulation of early endosome to late endosome transport (GO:2000641)2.36464320
155endocrine hormone secretion (GO:0060986)2.35794879
156stress fiber assembly (GO:0043149)2.32339345
157endodermal cell differentiation (GO:0035987)2.32162963
158regulation of protein localization to plasma membrane (GO:1903076)2.32088691
159negative regulation of fibrinolysis (GO:0051918)2.32003968
160membrane budding (GO:0006900)2.31274552
161regulation of extracellular matrix disassembly (GO:0010715)2.29787329
162positive regulation of transforming growth factor beta production (GO:0071636)2.24910151
163regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.23274112
164activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.22902038
165positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.22272176
166regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.21115018
167positive regulation of fibroblast migration (GO:0010763)2.20693898
168protein targeting to plasma membrane (GO:0072661)2.19448342
169clathrin coat assembly (GO:0048268)2.18520393
170endocytic recycling (GO:0032456)2.17244080
171regulation of plasminogen activation (GO:0010755)2.16075330
172fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.15089320
173apoptotic cell clearance (GO:0043277)2.13990458
174regulation of clathrin-mediated endocytosis (GO:2000369)2.12332958
175peptidyl-glutamic acid carboxylation (GO:0017187)2.12152877
176protein carboxylation (GO:0018214)2.12152877
177negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.12110463
178Golgi to plasma membrane transport (GO:0006893)2.11727550
179establishment of protein localization to plasma membrane (GO:0090002)2.11587347
180retina vasculature morphogenesis in camera-type eye (GO:0061299)2.10862386
181negative regulation of humoral immune response (GO:0002921)2.10718475
182negative regulation of homotypic cell-cell adhesion (GO:0034111)2.09651935
183regulation of short-term neuronal synaptic plasticity (GO:0048172)2.08911672
184positive regulation of cardiac muscle hypertrophy (GO:0010613)2.08773482
185positive regulation of muscle hypertrophy (GO:0014742)2.08773482
186response to gravity (GO:0009629)2.07751618
187cell-matrix adhesion (GO:0007160)2.07657326
188regulation of synaptic vesicle exocytosis (GO:2000300)2.06839205
189positive regulation of wound healing (GO:0090303)2.06540413
190regulation of fibrinolysis (GO:0051917)2.05419071
191negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.05347001
192hemoglobin metabolic process (GO:0020027)2.04793377
193regulation of complement activation (GO:0030449)2.04573998
194synaptic vesicle exocytosis (GO:0016079)2.04554939
195regulation of establishment of protein localization to plasma membrane (GO:0090003)2.03585923
196regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.02481539
197mating behavior (GO:0007617)2.02060506
198endoplasmic reticulum unfolded protein response (GO:0030968)2.02007721

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.25557617
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77262648
3MYC_22102868_ChIP-Seq_BL_Human3.58907501
4SCL_19346495_ChIP-Seq_HPC-7_Human3.57238717
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56328142
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.38551646
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34968732
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.29485597
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.28536055
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.24028469
11VDR_21846776_ChIP-Seq_THP-1_Human3.10050235
12E2F7_22180533_ChIP-Seq_HELA_Human3.07474470
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.89115726
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.86177073
15GATA1_22025678_ChIP-Seq_K562_Human2.80327141
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74885229
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.73398550
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.66370257
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63283967
20RUNX_20019798_ChIP-Seq_JUKART_Human2.58867523
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55317298
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54861525
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.53102096
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48968385
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.44968616
26TCF7_22412390_ChIP-Seq_EML_Mouse2.38472135
27MAF_26560356_Chip-Seq_TH1_Human2.37178558
28VDR_24763502_ChIP-Seq_THP-1_Human2.35494451
29MYB_26560356_Chip-Seq_TH2_Human2.34629674
30CDX2_19796622_ChIP-Seq_MESCs_Mouse2.29958854
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.27111383
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.26000738
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25250869
34ZNF217_24962896_ChIP-Seq_MCF-7_Human2.21925867
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.17548787
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13161657
37UTX_26944678_Chip-Seq_JUKART_Human2.12542501
38MYB_26560356_Chip-Seq_TH1_Human2.11019631
39ESR1_20079471_ChIP-ChIP_T-47D_Human2.09507676
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09054368
41FOXM1_23109430_ChIP-Seq_U2OS_Human2.08338029
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05428735
43SPI1_23127762_ChIP-Seq_K562_Human1.96352061
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.94848170
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.94643276
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.93788177
47CJUN_26792858_Chip-Seq_BT549_Human1.92944361
48SPI1_23547873_ChIP-Seq_NB4_Human1.90950416
49SOX2_20726797_ChIP-Seq_SW620_Human1.88541840
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87261091
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86815598
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.85830236
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85715090
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.85252282
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.85252282
56BP1_19119308_ChIP-ChIP_Hs578T_Human1.85250799
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.81565823
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.81565823
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.80368724
60KDM2B_26808549_Chip-Seq_DND41_Human1.78502339
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76449356
62TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75495384
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.73970284
64* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73338359
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73215610
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.72745592
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72424449
68BRD4_25478319_ChIP-Seq_HGPS_Human1.71926481
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71623148
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67021435
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.66510784
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.59751498
73RXR_22158963_ChIP-Seq_LIVER_Mouse1.58791863
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55365711
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.54139275
76GATA1_19941826_ChIP-Seq_K562_Human1.53370898
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52338646
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50811230
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.50774067
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49391078
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48778916
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47946853
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.47662705
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44273788
85LXR_22158963_ChIP-Seq_LIVER_Mouse1.43846127
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43129231
87GATA3_27048872_Chip-Seq_THYMUS_Human1.42293339
88* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.42263832
89* FOXA2_19822575_ChIP-Seq_HepG2_Human1.40456760
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38921895
91CLOCK_20551151_ChIP-Seq_293T_Human1.36779987
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35753242
93PU_27001747_Chip-Seq_BMDM_Mouse1.34846991
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34598419
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33449109
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30086341
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29714221
98PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.29464446
99GATA2_19941826_ChIP-Seq_K562_Human1.28455156
100Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27380932
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26747334
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26357300
103MAF_26560356_Chip-Seq_TH2_Human1.24330446
104CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22543078
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22335509
106TBX20_22080862_ChIP-Seq_HEART_Mouse1.21929360
107TBX20_22328084_ChIP-Seq_HEART_Mouse1.21929360
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21749391
109TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20409423
110NCOR1_26117541_ChIP-Seq_K562_Human1.20064410
111TP53_18474530_ChIP-ChIP_U2OS_Human1.19501164
112CIITA_25753668_ChIP-Seq_RAJI_Human1.17065288
113FOXO3_23340844_ChIP-Seq_DLD1_Human1.16926847
114LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15462661
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15294312
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14394730
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12958509
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11866944
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11685123
120ZNF263_19887448_ChIP-Seq_K562_Human1.11490127
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11060904
122TP53_16413492_ChIP-PET_HCT116_Human1.10837874
123VDR_24787735_ChIP-Seq_THP-1_Human1.09277264
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08670525
125TCF4_18268006_ChIP-ChIP_LS174T_Human1.08469131
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08266668
127NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07623046
128* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07581493
129TP63_23658742_ChIP-Seq_EP156T_Human1.07449853
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07130279
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05833879
132* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04955468
133AHR_22903824_ChIP-Seq_MCF-7_Human1.04076478
134KDM2B_26808549_Chip-Seq_JURKAT_Human1.03051393
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00426587
136EOMES_21245162_ChIP-Seq_HESCs_Human1.00107223
137FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99598669
138EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99395195
139GBX2_23144817_ChIP-Seq_PC3_Human0.98612633
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97545013
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.97350019
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97259792
143PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96040100
144LXR_22292898_ChIP-Seq_THP-1_Human0.95987675
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95081124
146ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95047946
147TET1_21490601_ChIP-Seq_MESCs_Mouse0.95002762
148GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94647584
149SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93723343
150FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93406214
151AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92560338
152CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91849524
153* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90494183
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90381031
155THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89940332
156GATA3_26560356_Chip-Seq_TH2_Human0.89921695
157ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89408460
158PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89154182
159MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.88818221
160GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87265189
161KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86709830
162P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85506630
163CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85263436
164ESR1_21235772_ChIP-Seq_MCF-7_Human0.85248828
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.84791032
166CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84318506
167FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.84154138
168TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83320547
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82601308
170* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82422260
171* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82317742

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.83423578
2MP0009780_abnormal_chondrocyte_physiolo3.73527567
3MP0003300_gastrointestinal_ulcer3.62656496
4MP0001835_abnormal_antigen_presentation3.30114891
5MP0003303_peritoneal_inflammation2.96359576
6MP0005275_abnormal_skin_tensile2.95062592
7MP0002396_abnormal_hematopoietic_system2.90581512
8MP0004272_abnormal_basement_membrane2.87991064
9MP0001800_abnormal_humoral_immune2.75728267
10MP0000685_abnormal_immune_system2.53811637
11MP0002877_abnormal_melanocyte_morpholog2.51325275
12MP0001790_abnormal_immune_system2.49570350
13MP0005387_immune_system_phenotype2.49570350
14MP0002166_altered_tumor_susceptibility2.47049285
15MP0003191_abnormal_cellular_cholesterol2.43546406
16MP0002452_abnormal_antigen_presenting2.42564328
17MP0009278_abnormal_bone_marrow2.41996102
18MP0006054_spinal_hemorrhage2.34387956
19MP0005671_abnormal_response_to2.33354172
20MP0000465_gastrointestinal_hemorrhage2.26387742
21MP0005464_abnormal_platelet_physiology2.24147701
22MP0004808_abnormal_hematopoietic_stem2.23742796
23MP0003329_amyloid_beta_deposits2.16812530
24MP0002723_abnormal_immune_serum2.10912885
25MP0001873_stomach_inflammation2.09531851
26MP0002420_abnormal_adaptive_immunity2.09412503
27MP0002398_abnormal_bone_marrow2.08079935
28MP0005000_abnormal_immune_tolerance2.07867268
29MP0001819_abnormal_immune_cell2.06985273
30MP0005058_abnormal_lysosome_morphology2.03242883
31MP0008004_abnormal_stomach_pH2.02338118
32MP0003436_decreased_susceptibility_to1.95760448
33MP0005397_hematopoietic_system_phenotyp1.94611964
34MP0001545_abnormal_hematopoietic_system1.94611964
35MP0000689_abnormal_spleen_morphology1.93337700
36MP0002419_abnormal_innate_immunity1.90491530
37MP0003950_abnormal_plasma_membrane1.89506989
38MP0000716_abnormal_immune_system1.86629278
39MP0005025_abnormal_response_to1.86481836
40MP0010155_abnormal_intestine_physiology1.86329196
41MP0008260_abnormal_autophagy1.81820021
42MP0009785_altered_susceptibility_to1.78109529
43MP0002722_abnormal_immune_system1.73810480
44MP0005623_abnormal_meninges_morphology1.72519733
45MP0006082_CNS_inflammation1.71754233
46MP0005164_abnormal_response_to1.63719581
47MP0000604_amyloidosis1.63280672
48MP0002295_abnormal_pulmonary_circulatio1.62714783
49MP0002429_abnormal_blood_cell1.62706957
50MP0003724_increased_susceptibility_to1.62547252
51MP0005409_darkened_coat_color1.61969196
52MP0001879_abnormal_lymphatic_vessel1.60735736
53MP0004947_skin_inflammation1.59872179
54MP0002006_tumorigenesis1.57853935
55MP0004859_abnormal_synaptic_plasticity1.57410671
56MP0001853_heart_inflammation1.54525301
57MP0002060_abnormal_skin_morphology1.51686329
58MP0001845_abnormal_inflammatory_respons1.49814665
59MP0005165_increased_susceptibility_to1.46902980
60MP0003172_abnormal_lysosome_physiology1.45962613
61MP0003866_abnormal_defecation1.45389366
62MP0002148_abnormal_hypersensitivity_rea1.43967667
63MP0000013_abnormal_adipose_tissue1.43235225
64MP0002405_respiratory_system_inflammati1.42723130
65MP0010234_abnormal_vibrissa_follicle1.41807433
66MP0003566_abnormal_cell_adhesion1.41469579
67MP0001542_abnormal_bone_strength1.40902735
68MP0003763_abnormal_thymus_physiology1.39152141
69MP0010352_gastrointestinal_tract_polyps1.35700320
70MP0005310_abnormal_salivary_gland1.33919330
71MP0002896_abnormal_bone_mineralization1.33786249
72MP0003868_abnormal_feces_composition1.33279699
73MP0000490_abnormal_crypts_of1.33050570
74MP0005503_abnormal_tendon_morphology1.32062518
75MP0000703_abnormal_thymus_morphology1.31336984
76MP0010386_abnormal_urinary_bladder1.28645640
77MP0001533_abnormal_skeleton_physiology1.27584787
78MP0003828_pulmonary_edema1.27461646
79MP0000920_abnormal_myelination1.26047167
80MP0003656_abnormal_erythrocyte_physiolo1.24087346
81MP0004270_analgesia1.20703043
82MP0010368_abnormal_lymphatic_system1.20314094
83MP0003045_fibrosis1.20253678
84MP0004147_increased_porphyrin_level1.17676473
85MP0008469_abnormal_protein_level1.17407672
86MP0001851_eye_inflammation1.12168486
87MP0000751_myopathy1.09258388
88MP0005257_abnormal_intraocular_pressure1.08603409
89MP0000343_altered_response_to1.08188535
90MP0009333_abnormal_splenocyte_physiolog1.05568870
91MP0010329_abnormal_lipoprotein_level1.04033137
92MP0004883_abnormal_blood_vessel1.03065020
93MP0002933_joint_inflammation1.02800529
94MP0000003_abnormal_adipose_tissue1.02333246
95MP0002136_abnormal_kidney_physiology0.99816467
96MP0003183_abnormal_peptide_metabolism0.99450615
97MP0003075_altered_response_to0.97271449
98MP0004510_myositis0.97252380
99MP0009840_abnormal_foam_cell0.96742981
100MP0004484_altered_response_of0.95613886
101MP0002909_abnormal_adrenal_gland0.95379313
102MP0002796_impaired_skin_barrier0.95055566
103MP0000249_abnormal_blood_vessel0.93603728
104MP0005670_abnormal_white_adipose0.92024639
105MP0005365_abnormal_bile_salt0.91691829
106MP0005166_decreased_susceptibility_to0.91613345
107MP0003091_abnormal_cell_migration0.90310739
108MP0001243_abnormal_dermal_layer0.88489856
109MP0001663_abnormal_digestive_system0.86061533
110MP0008874_decreased_physiological_sensi0.86007694
111MP0002019_abnormal_tumor_incidence0.84095020
112MP0005167_abnormal_blood-brain_barrier0.83772656
113MP0010307_abnormal_tumor_latency0.83409758
114MP0002332_abnormal_exercise_endurance0.83229891
115MP0002928_abnormal_bile_duct0.83094398
116MP0004130_abnormal_muscle_cell0.83062832
117MP0008961_abnormal_basal_metabolism0.82190637
118MP0005595_abnormal_vascular_smooth0.81741255
119MP0005076_abnormal_cell_differentiation0.81151670
120MP0004084_abnormal_cardiac_muscle0.80638658
121MP0002998_abnormal_bone_remodeling0.80361274
122MP0009643_abnormal_urine_homeostasis0.80282688
123MP0001915_intracranial_hemorrhage0.80279144
124MP0001958_emphysema0.80051167
125MP0003879_abnormal_hair_cell0.79563317
126MP0005174_abnormal_tail_pigmentation0.79544834
127MP0000767_abnormal_smooth_muscle0.78318154
128MP0003448_altered_tumor_morphology0.78185689
129MP0005023_abnormal_wound_healing0.78126923
130MP0006138_congestive_heart_failure0.77068914
131MP0002133_abnormal_respiratory_system0.76720017
132MP0005388_respiratory_system_phenotype0.76720017
133MP0002971_abnormal_brown_adipose0.76253742
134MP0003279_aneurysm0.76162176
135MP0004185_abnormal_adipocyte_glucose0.76041571
136MP0005621_abnormal_cell_physiology0.75940302
137MP0000609_abnormal_liver_physiology0.74841541
138MP0005375_adipose_tissue_phenotype0.74326235
139MP0000477_abnormal_intestine_morphology0.73717271
140MP0008775_abnormal_heart_ventricle0.72167270
141MP0003453_abnormal_keratinocyte_physiol0.71629730
142MP0001666_abnormal_nutrient_absorption0.71328696
143MP0010771_integument_phenotype0.71217794
144MP0002139_abnormal_hepatobiliary_system0.71194637
145MP0009764_decreased_sensitivity_to0.71085129
146MP0003690_abnormal_glial_cell0.70241449
147MP0003705_abnormal_hypodermis_morpholog0.70142575
148MP0002118_abnormal_lipid_homeostasis0.70072833
149MP0001299_abnormal_eye_distance/0.69395941
150MP0004782_abnormal_surfactant_physiolog0.68701628
151MP0008569_lethality_at_weaning0.68548619
152MP0004036_abnormal_muscle_relaxation0.67756175
153MP0000639_abnormal_adrenal_gland0.66210189
154MP0000598_abnormal_liver_morphology0.65317246
155MP0000858_altered_metastatic_potential0.64945733
156MP0009046_muscle_twitch0.64835992
157MP0009763_increased_sensitivity_to0.64660477
158MP0003633_abnormal_nervous_system0.63587112
159MP0002009_preneoplasia0.63389814
160MP0005085_abnormal_gallbladder_physiolo0.63111921
161MP0005501_abnormal_skin_physiology0.62341648
162MP0005330_cardiomyopathy0.62286359
163MP0002135_abnormal_kidney_morphology0.62174773
164MP0003635_abnormal_synaptic_transmissio0.61626414

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)5.64337320
2Cellulitis (HP:0100658)5.47037374
3Verrucae (HP:0200043)4.45017253
4Papilloma (HP:0012740)4.45017253
5Premature rupture of membranes (HP:0001788)4.36106773
6Colitis (HP:0002583)4.35129771
7Recurrent bronchitis (HP:0002837)4.07047514
8Recurrent viral infections (HP:0004429)4.06128030
9Hematochezia (HP:0002573)4.04935823
10Protrusio acetabuli (HP:0003179)3.95363526
11Inflammation of the large intestine (HP:0002037)3.93288291
12Chronic otitis media (HP:0000389)3.86495772
13Gastrointestinal inflammation (HP:0004386)3.85755200
14IgM deficiency (HP:0002850)3.77581067
15Abnormality of B cell number (HP:0010975)3.53166399
16B lymphocytopenia (HP:0010976)3.53166399
17Osteomyelitis (HP:0002754)3.49698427
18Follicular hyperkeratosis (HP:0007502)3.47175252
19Meningitis (HP:0001287)3.44538030
20Spontaneous hematomas (HP:0007420)3.43194738
21Panhypogammaglobulinemia (HP:0003139)3.37744137
22Gastrointestinal stroma tumor (HP:0100723)3.34300068
23Aortic aneurysm (HP:0004942)3.27601022
24Thyroiditis (HP:0100646)3.24686012
25Neurofibrillary tangles (HP:0002185)3.23686451
26Recurrent abscess formation (HP:0002722)3.17950384
27Recurrent fungal infections (HP:0002841)3.16348034
28Interstitial pulmonary disease (HP:0006530)3.13585051
29Vertebral compression fractures (HP:0002953)3.09977544
30Recurrent bacterial skin infections (HP:0005406)3.02717847
31Menorrhagia (HP:0000132)3.01572124
32Abnormality of the nasal mucosa (HP:0000433)2.97319071
33Cerebral aneurysm (HP:0004944)2.95587966
34Systemic lupus erythematosus (HP:0002725)2.92238484
35Thrombocytosis (HP:0001894)2.91534773
36Impaired platelet aggregation (HP:0003540)2.89178092
37Abnormal platelet function (HP:0011869)2.89178092
38Chronic sinusitis (HP:0011109)2.88203923
39Atrophic scars (HP:0001075)2.86512580
40Prolonged bleeding time (HP:0003010)2.86458642
41Supranuclear gaze palsy (HP:0000605)2.85937125
42Cerebral inclusion bodies (HP:0100314)2.82100675
43Increased cerebral lipofuscin (HP:0011813)2.78547381
44Cardiovascular calcification (HP:0011915)2.76314547
45Glomerulonephritis (HP:0000099)2.75567338
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.73442876
47Fatigue (HP:0012378)2.69115420
48Abnormality of the fingertips (HP:0001211)2.64642323
49Dysostosis multiplex (HP:0000943)2.63645063
50Abnormality of the common coagulation pathway (HP:0010990)2.63503129
51Nasal polyposis (HP:0100582)2.60675822
52Eczematoid dermatitis (HP:0000976)2.58846231
53Vascular calcification (HP:0004934)2.55385970
54Wormian bones (HP:0002645)2.53762888
55Gingival bleeding (HP:0000225)2.53065400
56Tetraparesis (HP:0002273)2.52382264
57Increased mean platelet volume (HP:0011877)2.50879808
58Sepsis (HP:0100806)2.49175617
59Lymphopenia (HP:0001888)2.48957769
60Emphysema (HP:0002097)2.48346184
61Glucose intolerance (HP:0000833)2.48220533
62Deep venous thrombosis (HP:0002625)2.47719509
63Recurrent sinusitis (HP:0011108)2.47166106
64Right ventricular cardiomyopathy (HP:0011663)2.41937132
65Petechiae (HP:0000967)2.39851696
66Arterial tortuosity (HP:0005116)2.39802618
67Autoimmune thrombocytopenia (HP:0001973)2.38353815
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.35024575
69Myositis (HP:0100614)2.34978469
70Cervical subluxation (HP:0003308)2.34639997
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.34327867
72Facial diplegia (HP:0001349)2.33247618
73Hand muscle atrophy (HP:0009130)2.32879150
74Vasculitis (HP:0002633)2.32430600
75Growth hormone excess (HP:0000845)2.31883902
76Pustule (HP:0200039)2.31416704
77Upper limb amyotrophy (HP:0009129)2.30334158
78Distal upper limb amyotrophy (HP:0007149)2.30334158
79Recurrent skin infections (HP:0001581)2.27733693
80Vacuolated lymphocytes (HP:0001922)2.27370110
81Autoamputation (HP:0001218)2.26460809
82Action tremor (HP:0002345)2.25196897
83Mitral stenosis (HP:0001718)2.22254634
84Myocardial infarction (HP:0001658)2.21404571
85Peritonitis (HP:0002586)2.21009170
86Abnormality of T cell physiology (HP:0011840)2.20963003
87Recurrent pneumonia (HP:0006532)2.20838631
88Polycythemia (HP:0001901)2.19836538
89Bronchitis (HP:0012387)2.19388840
90T lymphocytopenia (HP:0005403)2.19301382
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19051302
92Insidious onset (HP:0003587)2.18089404
93Termporal pattern (HP:0011008)2.18089404
94Mucopolysacchariduria (HP:0008155)2.17922991
95Urinary glycosaminoglycan excretion (HP:0003541)2.17922991
96Abnormality of T cells (HP:0002843)2.17006080
97Epistaxis (HP:0000421)2.15140956
98Alopecia of scalp (HP:0002293)2.14864781
99Increased IgE level (HP:0003212)2.13497771
100Eosinophilia (HP:0001880)2.13351244
101Ankle contracture (HP:0006466)2.10944931
102Fragile skin (HP:0001030)2.10460743
103Hypoplasia of the thymus (HP:0000778)2.09857337
104Vascular tortuosity (HP:0004948)2.09817102
105Osteolytic defects of the hand bones (HP:0009699)2.09056246
106Osteolytic defects of the phalanges of the hand (HP:0009771)2.09056246
107Chronic diarrhea (HP:0002028)2.08859151
108Dilatation of the ascending aorta (HP:0005111)2.08853120
109Short nail (HP:0001799)2.07425636
110Recurrent lower respiratory tract infections (HP:0002783)2.06865197
111Complement deficiency (HP:0004431)2.05822547
112Arterial thrombosis (HP:0004420)2.05806354
113IgA deficiency (HP:0002720)2.05056647
114Aortic dissection (HP:0002647)2.03746453
115Spondylolisthesis (HP:0003302)2.03020763
116Recurrent cutaneous fungal infections (HP:0011370)2.02442263
117Chronic mucocutaneous candidiasis (HP:0002728)2.02442263
118Abnormality of T cell number (HP:0011839)2.02087676
119Restrictive lung disease (HP:0002091)2.00456781
120Reduced subcutaneous adipose tissue (HP:0003758)1.99270308
121Skin ulcer (HP:0200042)1.99238169
122Abnormality of glycolipid metabolism (HP:0010969)1.97266106
123Abnormality of liposaccharide metabolism (HP:0010968)1.97266106
124Abnormality of glycosphingolipid metabolism (HP:0004343)1.97266106
125Small epiphyses (HP:0010585)1.96743355
126Periodontitis (HP:0000704)1.96722524
127Abnormal platelet volume (HP:0011876)1.96316721
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96183199
129Abnormality of polysaccharide metabolism (HP:0011012)1.96183199
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96183199
131Nephritis (HP:0000123)1.94772994
132Skin rash (HP:0000988)1.94562451
133Papilledema (HP:0001085)1.94421423
134Disinhibition (HP:0000734)1.94118369
135Elevated erythrocyte sedimentation rate (HP:0003565)1.93803699
136Striae distensae (HP:0001065)1.93441294
137Aneurysm (HP:0002617)1.93136991
138Scanning speech (HP:0002168)1.91399724
139Abnormal delivery (HP:0001787)1.91377264
140Abnormality of the thoracic spine (HP:0100711)1.90926119
141Ankyloglossia (HP:0010296)1.90808353
142Granulocytopenia (HP:0001913)1.90147946
143Papillary thyroid carcinoma (HP:0002895)1.89357974
144Chest pain (HP:0100749)1.88963188
145Purpura (HP:0000979)1.86636005
146Distal lower limb amyotrophy (HP:0008944)1.83895351
147Amyloidosis (HP:0011034)1.83690815
148Menstrual irregularities (HP:0000858)1.83307717
149Abnormal glucose tolerance (HP:0001952)1.82583355
150Blue sclerae (HP:0000592)1.78367307
151Skin nodule (HP:0200036)1.75439182
152Abnormality of oral frenula (HP:0000190)1.74773933
153Metaphyseal dysplasia (HP:0100255)1.72736596
154Hypokinesia (HP:0002375)1.72673140
155Intention tremor (HP:0002080)1.71584604
156Nuclear cataract (HP:0100018)1.71399695
157Joint hemorrhage (HP:0005261)1.70654847
158Abnormality of carpal bone ossification (HP:0006257)1.70288657
159Abnormality of the intrinsic pathway (HP:0010989)1.67626109
160Upper limb muscle weakness (HP:0003484)1.67177373
161Ovoid vertebral bodies (HP:0003300)1.66600704
162Lower limb amyotrophy (HP:0007210)1.66523101
163Spinal rigidity (HP:0003306)1.64996347
164Soft skin (HP:0000977)1.64687322
165Back pain (HP:0003418)1.64343068
166Hyperlipoproteinemia (HP:0010980)1.62473260
167Bladder diverticulum (HP:0000015)1.62409922
168Unilateral renal agenesis (HP:0000122)1.62179056
169Broad face (HP:0000283)1.61573090
170Abnormality of the acetabulum (HP:0003170)1.60029406
171Hyperextensible skin (HP:0000974)1.59729073
172Distal lower limb muscle weakness (HP:0009053)1.59687530
173Axonal loss (HP:0003447)1.57184066
174Hypoalphalipoproteinemia (HP:0003233)1.56046813
175Delayed closure of the anterior fontanelle (HP:0001476)1.55738733
176Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.55682657

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.34174154
2MAP3K104.19270284
3TGFBR23.92368016
4MAP4K13.46387667
5ERN13.38499551
6MAP3K122.75746448
7TESK12.58267476
8TRIB32.49597487
9CSF1R2.39357095
10MYLK2.35734230
11STK102.26682445
12PKN22.22913028
13PDGFRA2.12753062
14NTRK12.05384444
15EPHA22.04243003
16MST1R2.02766554
17TYK22.02352836
18LATS22.01299398
19BLK2.00762649
20LIMK11.98964616
21AKT31.98317687
22MAP3K21.95107199
23GRK61.94385977
24MAP3K91.90204874
25BTK1.87770594
26LRRK21.82616277
27ARAF1.79127563
28STK381.74452055
29PTK21.74288165
30MET1.68898160
31KIT1.66011424
32FER1.64307293
33SYK1.58878448
34EPHB11.55133313
35CAMK1D1.53837396
36JAK11.53194740
37SCYL21.47422018
38JAK31.38422955
39KSR21.38287018
40RIPK41.36861672
41PAK61.36427048
42ZAP701.36082459
43TBK11.35968451
44ERBB41.35916378
45MAP2K31.30247391
46CAMKK21.29296014
47PTK61.28057674
48ITK1.26752489
49MAP3K31.26651136
50TAOK31.25274043
51MAPKAPK31.24143865
52MATK1.23778518
53KDR1.22804705
54CAMK1G1.21554339
55MAP3K61.20495295
56SIK11.16511791
57CLK11.14127561
58RPS6KB21.12811562
59FGFR31.12364817
60TEC1.12219386
61HCK1.11955598
62EPHA41.11725209
63LATS11.10185684
64FES1.08647313
65TIE11.06656129
66SIK21.06638766
67KSR11.06227409
68FRK1.05849796
69NTRK31.05728948
70PDGFRB1.04208117
71CDK121.03479058
72PAK31.03262245
73DDR21.03215801
74SIK31.02498528
75RIPK11.01744687
76LYN0.99932925
77PLK20.99646313
78MOS0.98675063
79CDK60.98286082
80BMPR20.97474317
81PRPF4B0.97165951
82PTK2B0.93215627
83LCK0.91829025
84DAPK20.91350911
85CSK0.91252068
86STK40.90554574
87GRK50.90538184
88PAK40.90434893
89ERBB30.90243117
90EIF2AK10.90063945
91TGFBR10.89672334
92CDK40.89652666
93MINK10.89180212
94FGFR40.88847470
95PRKD30.87527018
96JAK20.86591547
97MAPK120.86245515
98CDK90.85018016
99FLT30.84322434
100NEK60.82956144
101PIM10.80296055
102MAP3K10.79948077
103MAPK110.77193820
104TRPM70.75292550
105MAPK150.73538758
106NEK20.72238859
107NEK90.70562221
108IRAK40.70258086
109BCR0.68818512
110ROCK20.67720208
111RPS6KA40.67709566
112SGK30.66660847
113YES10.66526975
114MAPK40.66218707
115MAP3K70.66191187
116IKBKE0.65248789
117TTN0.65122851
118RAF10.64864777
119MARK10.64845585
120PDK10.64143432
121PRKG20.63895922
122IRAK30.63737495
123MAP2K10.62008622
124IKBKB0.61712041
125MST40.60580285
126PHKG10.59738078
127PHKG20.59738078
128HIPK20.59576549
129PAK20.59394835
130CAMK2B0.58473080
131MAP3K130.54958140
132MARK20.53839798
133MAP3K50.53765484
134MAP3K80.52690689
135CAMK2G0.52345512
136ICK0.50909639
137MARK30.50814990
138TNK20.50546105
139ABL20.50371652
140PIK3CG0.50195619
141CAMK2D0.49929014
142PRKD10.49876265
143PRKCE0.49314772
144DAPK10.46950196
145PRKD20.46916039
146RET0.46665726
147STK30.46559486
148NLK0.45768018
149FGFR20.44144777
150CDK140.44110926
151EPHA30.44025785
152WNK10.42907434
153MAP3K140.42893162
154MAPKAPK20.42728086
155CDK50.42385780
156CDK180.42179231
157MAPKAPK50.41898092
158LMTK20.41657700
159STK38L0.41434471
160ILK0.41343103
161DMPK0.41316180
162EGFR0.41206121
163DYRK1B0.39420586
164PDPK10.36430526
165MELK0.35372691
166TXK0.34373923
167PRKCH0.32937554
168STK390.32833092
169ABL10.31676532
170PRKAA20.31128979

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046623.90280462
2Primary immunodeficiency_Homo sapiens_hsa053403.53326179
3Osteoclast differentiation_Homo sapiens_hsa043802.52855208
4Leishmaniasis_Homo sapiens_hsa051402.18889063
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12655946
6Antigen processing and presentation_Homo sapiens_hsa046122.04650280
7Other glycan degradation_Homo sapiens_hsa005111.97482971
8Hematopoietic cell lineage_Homo sapiens_hsa046401.95354202
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.89015408
10Synaptic vesicle cycle_Homo sapiens_hsa047211.88753579
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.86672442
12Staphylococcus aureus infection_Homo sapiens_hsa051501.84934770
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80462036
14Chronic myeloid leukemia_Homo sapiens_hsa052201.79102438
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.75908718
16Vibrio cholerae infection_Homo sapiens_hsa051101.75505127
17Platelet activation_Homo sapiens_hsa046111.74406405
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.74350244
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.70948246
20Toxoplasmosis_Homo sapiens_hsa051451.69228676
21Measles_Homo sapiens_hsa051621.59224534
22Pancreatic cancer_Homo sapiens_hsa052121.55263026
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47062048
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46931553
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45759904
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40957839
27Acute myeloid leukemia_Homo sapiens_hsa052211.39509896
28Lysosome_Homo sapiens_hsa041421.36205586
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35440303
30Long-term potentiation_Homo sapiens_hsa047201.35001196
31Pertussis_Homo sapiens_hsa051331.33542667
32Non-small cell lung cancer_Homo sapiens_hsa052231.31009994
33Tuberculosis_Homo sapiens_hsa051521.29156809
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29074792
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29030306
36Caffeine metabolism_Homo sapiens_hsa002321.27639597
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27144875
38Hepatitis B_Homo sapiens_hsa051611.25771285
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.24614922
40Chemokine signaling pathway_Homo sapiens_hsa040621.20563983
41Small cell lung cancer_Homo sapiens_hsa052221.20560186
42Fatty acid elongation_Homo sapiens_hsa000621.17398559
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16028545
44T cell receptor signaling pathway_Homo sapiens_hsa046601.15509464
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14747171
46Influenza A_Homo sapiens_hsa051641.12146829
47Shigellosis_Homo sapiens_hsa051311.11318661
48Apoptosis_Homo sapiens_hsa042101.09541893
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07783200
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07417932
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04452484
52Amphetamine addiction_Homo sapiens_hsa050311.04265013
53Renin-angiotensin system_Homo sapiens_hsa046141.02351275
54Herpes simplex infection_Homo sapiens_hsa051681.01731369
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.01669694
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01214360
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00632108
58Malaria_Homo sapiens_hsa051440.99648776
59Renin secretion_Homo sapiens_hsa049240.99229210
60Collecting duct acid secretion_Homo sapiens_hsa049660.97863530
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96668453
62VEGF signaling pathway_Homo sapiens_hsa043700.94834751
63Sulfur metabolism_Homo sapiens_hsa009200.94319686
64Prion diseases_Homo sapiens_hsa050200.94222931
65Sphingolipid metabolism_Homo sapiens_hsa006000.93965394
66Insulin resistance_Homo sapiens_hsa049310.92364721
67Vitamin B6 metabolism_Homo sapiens_hsa007500.89690241
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89470141
69Fatty acid biosynthesis_Homo sapiens_hsa000610.88971056
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88781630
71Circadian rhythm_Homo sapiens_hsa047100.87501080
72Focal adhesion_Homo sapiens_hsa045100.87494081
73Dopaminergic synapse_Homo sapiens_hsa047280.87251447
74GnRH signaling pathway_Homo sapiens_hsa049120.86867654
75Viral carcinogenesis_Homo sapiens_hsa052030.86406809
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85713243
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85566728
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85515279
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85467866
80N-Glycan biosynthesis_Homo sapiens_hsa005100.85249394
81PPAR signaling pathway_Homo sapiens_hsa033200.85205464
82Colorectal cancer_Homo sapiens_hsa052100.84391969
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82669173
84Thyroid hormone synthesis_Homo sapiens_hsa049180.82536403
85Endocytosis_Homo sapiens_hsa041440.82033027
86Non-homologous end-joining_Homo sapiens_hsa034500.81656724
87Gastric acid secretion_Homo sapiens_hsa049710.81405827
88Legionellosis_Homo sapiens_hsa051340.81228344
89Gap junction_Homo sapiens_hsa045400.80636647
90TNF signaling pathway_Homo sapiens_hsa046680.80461319
91Hepatitis C_Homo sapiens_hsa051600.80425889
92GABAergic synapse_Homo sapiens_hsa047270.79707133
93Nitrogen metabolism_Homo sapiens_hsa009100.77709572
94Insulin secretion_Homo sapiens_hsa049110.77701642
95Salmonella infection_Homo sapiens_hsa051320.76041500
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76019307
97Pancreatic secretion_Homo sapiens_hsa049720.75945320
98Glioma_Homo sapiens_hsa052140.75227536
99FoxO signaling pathway_Homo sapiens_hsa040680.74068942
100ABC transporters_Homo sapiens_hsa020100.73850359
101Viral myocarditis_Homo sapiens_hsa054160.73681499
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72760752
103Salivary secretion_Homo sapiens_hsa049700.72569177
104Estrogen signaling pathway_Homo sapiens_hsa049150.72533826
105Bile secretion_Homo sapiens_hsa049760.72432996
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.72262500
107Fatty acid metabolism_Homo sapiens_hsa012120.72160399
108Renal cell carcinoma_Homo sapiens_hsa052110.71438715
109Long-term depression_Homo sapiens_hsa047300.71388520
110mTOR signaling pathway_Homo sapiens_hsa041500.70909024
111HTLV-I infection_Homo sapiens_hsa051660.70721734
112Dilated cardiomyopathy_Homo sapiens_hsa054140.70647613
113Mineral absorption_Homo sapiens_hsa049780.70635168
114Phagosome_Homo sapiens_hsa041450.70120555
115Dorso-ventral axis formation_Homo sapiens_hsa043200.69791644
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69725145
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69134856
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68867051
119ErbB signaling pathway_Homo sapiens_hsa040120.68845054
120Proteoglycans in cancer_Homo sapiens_hsa052050.67122385
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66644014
122Inositol phosphate metabolism_Homo sapiens_hsa005620.66233121
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64876713
124Thyroid cancer_Homo sapiens_hsa052160.64433344
125Circadian entrainment_Homo sapiens_hsa047130.64131791
126HIF-1 signaling pathway_Homo sapiens_hsa040660.62663296
127Prolactin signaling pathway_Homo sapiens_hsa049170.62369011
128Amoebiasis_Homo sapiens_hsa051460.61713162
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.61487401
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.60895080
131Endometrial cancer_Homo sapiens_hsa052130.60336706
132Cocaine addiction_Homo sapiens_hsa050300.59335522
133Rap1 signaling pathway_Homo sapiens_hsa040150.59252690
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59131256
135Insulin signaling pathway_Homo sapiens_hsa049100.58304838
136Glutamatergic synapse_Homo sapiens_hsa047240.58222457
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58218844
138Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58170708
139Lysine degradation_Homo sapiens_hsa003100.57903972
140Prostate cancer_Homo sapiens_hsa052150.57444001
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57158559
142MicroRNAs in cancer_Homo sapiens_hsa052060.56934548
143Epstein-Barr virus infection_Homo sapiens_hsa051690.55718734
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55016037
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54466619
146Protein digestion and absorption_Homo sapiens_hsa049740.54332533
147Phospholipase D signaling pathway_Homo sapiens_hsa040720.54078384
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54072089
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.53524666
150Systemic lupus erythematosus_Homo sapiens_hsa053220.52849667
151Notch signaling pathway_Homo sapiens_hsa043300.52678113
152PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52108823
153Complement and coagulation cascades_Homo sapiens_hsa046100.44657896
154Adherens junction_Homo sapiens_hsa045200.44152880
155ECM-receptor interaction_Homo sapiens_hsa045120.43062348
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42649228
157Choline metabolism in cancer_Homo sapiens_hsa052310.42190867
158Pathways in cancer_Homo sapiens_hsa052000.41707190
159Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41418745

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