SERINC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.96960958
2central nervous system myelination (GO:0022010)7.96960958
3regulation of rhodopsin mediated signaling pathway (GO:0022400)7.87058431
4rhodopsin mediated signaling pathway (GO:0016056)7.75425132
5pyrimidine nucleobase catabolic process (GO:0006208)5.94938977
6photoreceptor cell maintenance (GO:0045494)5.78515675
7photoreceptor cell differentiation (GO:0046530)5.57388985
8eye photoreceptor cell differentiation (GO:0001754)5.57388985
9detection of light stimulus involved in sensory perception (GO:0050962)5.52246622
10detection of light stimulus involved in visual perception (GO:0050908)5.52246622
11retinal cone cell development (GO:0046549)5.42938139
12photoreceptor cell development (GO:0042461)5.08186936
13eye photoreceptor cell development (GO:0042462)4.93224640
14nucleobase catabolic process (GO:0046113)4.63545123
15behavioral response to nicotine (GO:0035095)4.45972647
16positive regulation of mitochondrial fission (GO:0090141)4.43635840
17acrosome reaction (GO:0007340)4.40532492
18neuron cell-cell adhesion (GO:0007158)4.37090147
19sequestering of actin monomers (GO:0042989)4.30625130
20nonmotile primary cilium assembly (GO:0035058)4.28900038
21detection of visible light (GO:0009584)4.27899143
22detection of light stimulus (GO:0009583)4.21105049
23phototransduction (GO:0007602)4.20248731
24presynaptic membrane organization (GO:0097090)4.15244634
25retinal rod cell development (GO:0046548)4.13123327
26phototransduction, visible light (GO:0007603)4.08626400
27regulation of cilium movement (GO:0003352)4.04508162
28GMP metabolic process (GO:0046037)4.02643561
29response to pheromone (GO:0019236)3.92794694
30single strand break repair (GO:0000012)3.85331230
31visual perception (GO:0007601)3.85122115
32sensory perception of light stimulus (GO:0050953)3.83776377
33positive regulation of amino acid transport (GO:0051957)3.70735292
34positive regulation of guanylate cyclase activity (GO:0031284)3.70674675
35axonal fasciculation (GO:0007413)3.70426857
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67063412
37long-chain fatty acid biosynthetic process (GO:0042759)3.61540012
38presynaptic membrane assembly (GO:0097105)3.60755537
39activated T cell proliferation (GO:0050798)3.60699456
40protein-chromophore linkage (GO:0018298)3.58791688
41sperm motility (GO:0030317)3.58025854
42neuron recognition (GO:0008038)3.48555905
43aggressive behavior (GO:0002118)3.47810995
44mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.45570327
45positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.45570327
46cilium morphogenesis (GO:0060271)3.38682554
47limb bud formation (GO:0060174)3.33846290
48GPI anchor metabolic process (GO:0006505)3.32372794
49microtubule depolymerization (GO:0007019)3.31821010
50DNA integration (GO:0015074)3.27332172
51regulation of guanylate cyclase activity (GO:0031282)3.27141337
52fatty acid elongation (GO:0030497)3.26622452
53detection of external stimulus (GO:0009581)3.25076099
54retina development in camera-type eye (GO:0060041)3.23692159
55detection of abiotic stimulus (GO:0009582)3.20551006
56spermatid nucleus differentiation (GO:0007289)3.15171085
57gamma-aminobutyric acid transport (GO:0015812)3.13457746
58glyoxylate metabolic process (GO:0046487)3.12060593
59protein localization to synapse (GO:0035418)3.11561000
60GPI anchor biosynthetic process (GO:0006506)3.10907276
61ATP synthesis coupled proton transport (GO:0015986)3.10085411
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.10085411
63protein polyglutamylation (GO:0018095)3.09217444
64platelet dense granule organization (GO:0060155)3.07245717
65retina layer formation (GO:0010842)3.05645577
66ubiquinone metabolic process (GO:0006743)3.04749263
67olfactory bulb development (GO:0021772)3.04491896
68keratinocyte development (GO:0003334)3.02321109
69base-excision repair, AP site formation (GO:0006285)3.01551777
70positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.00397277
71neuromuscular synaptic transmission (GO:0007274)2.99173574
72calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.98798714
73regulation of feeding behavior (GO:0060259)2.98501897
74ubiquinone biosynthetic process (GO:0006744)2.97707473
75regulation of microtubule-based movement (GO:0060632)2.97593514
76axoneme assembly (GO:0035082)2.97476310
77C4-dicarboxylate transport (GO:0015740)2.95026915
78regulation of mitochondrial fission (GO:0090140)2.94131596
79regulation of development, heterochronic (GO:0040034)2.93796814
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93016455
81neuron remodeling (GO:0016322)2.92787757
82atrial cardiac muscle cell action potential (GO:0086014)2.91287413
83seminiferous tubule development (GO:0072520)2.90941932
84positive regulation of oligodendrocyte differentiation (GO:0048714)2.84949540
85positive regulation of action potential (GO:0045760)2.83541666
86water-soluble vitamin biosynthetic process (GO:0042364)2.83290841
87establishment of mitochondrion localization (GO:0051654)2.83177521
88cilium organization (GO:0044782)2.79428599
89mannosylation (GO:0097502)2.78731640
90regulation of mitochondrial translation (GO:0070129)2.78349179
91dopamine biosynthetic process (GO:0042416)2.77517090
92phosphorelay signal transduction system (GO:0000160)2.75464291
93centriole replication (GO:0007099)2.75302936
94cysteine metabolic process (GO:0006534)2.74485883
95myelination (GO:0042552)2.73517388
96glycolipid biosynthetic process (GO:0009247)2.73486855
97postsynaptic membrane organization (GO:0001941)2.73389061
98cilium assembly (GO:0042384)2.72130337
99epithelial cilium movement (GO:0003351)2.71462376
100cellular response to light stimulus (GO:0071482)2.70599639
101negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70379249
102cilium movement (GO:0003341)2.70067184
103NADH dehydrogenase complex assembly (GO:0010257)2.69704957
104mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69704957
105mitochondrial respiratory chain complex I assembly (GO:0032981)2.69704957
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68672037
107tachykinin receptor signaling pathway (GO:0007217)2.68226113
108dendritic spine morphogenesis (GO:0060997)2.67092236
109cellular response to leptin stimulus (GO:0044320)2.66488700
110calcium ion-dependent exocytosis (GO:0017156)2.66044107
111cilium or flagellum-dependent cell motility (GO:0001539)2.65469713
112L-serine transport (GO:0015825)2.65448474
113protein complex biogenesis (GO:0070271)2.65340267
114ensheathment of neurons (GO:0007272)2.64387381
115axon ensheathment (GO:0008366)2.64387381
116urogenital system development (GO:0001655)2.64353110
117axonemal dynein complex assembly (GO:0070286)2.63043141
118serine family amino acid catabolic process (GO:0009071)2.62877251
119spermatid development (GO:0007286)2.61935517
120protein localization to peroxisome (GO:0072662)2.60857640
121protein targeting to peroxisome (GO:0006625)2.60857640
122establishment of protein localization to peroxisome (GO:0072663)2.60857640
123cranial nerve development (GO:0021545)2.60475872
124glutamate receptor signaling pathway (GO:0007215)2.60473592
125eyelid development in camera-type eye (GO:0061029)2.59752686
126regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.58403863
127negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.58288041
128mitochondrial respiratory chain complex assembly (GO:0033108)2.56420979
129cellular ketone body metabolic process (GO:0046950)2.56369516
130import into cell (GO:0098657)2.56204941
131positive regulation of TOR signaling (GO:0032008)2.55433099
132hippocampus development (GO:0021766)2.54648790
133regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.54537889
134sperm-egg recognition (GO:0035036)2.53669843
135binding of sperm to zona pellucida (GO:0007339)2.52766916
136positive regulation of organic acid transport (GO:0032892)2.52729561
137intraciliary transport (GO:0042073)2.52578070
138desmosome organization (GO:0002934)2.50911367
139magnesium ion transport (GO:0015693)2.50640775
140preassembly of GPI anchor in ER membrane (GO:0016254)2.50639612
141regulation of oligodendrocyte differentiation (GO:0048713)2.50254857
142regulation of voltage-gated calcium channel activity (GO:1901385)2.49790209
143negative regulation of astrocyte differentiation (GO:0048712)2.49720873
144sensory perception of smell (GO:0007608)2.48873084
145ionotropic glutamate receptor signaling pathway (GO:0035235)2.48712446
146urinary tract smooth muscle contraction (GO:0014848)2.48127892
147growth hormone secretion (GO:0030252)2.47833445
148negative regulation of appetite (GO:0032099)2.47787098
149negative regulation of response to food (GO:0032096)2.47787098
150intracellular protein transmembrane import (GO:0044743)2.47408958
151serine transport (GO:0032329)2.47115230
152dendrite development (GO:0016358)2.46976469
153quinone biosynthetic process (GO:1901663)2.46605663
154microtubule polymerization or depolymerization (GO:0031109)2.45606247
155auditory behavior (GO:0031223)2.45434835
156meiosis I (GO:0007127)2.43684157
157head development (GO:0060322)2.43673006
158protein localization to Golgi apparatus (GO:0034067)2.43374908
159neurotransmitter metabolic process (GO:0042133)2.43261830
160DNA double-strand break processing (GO:0000729)2.42947198
161epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42502949
162regulation of astrocyte differentiation (GO:0048710)2.42448856
163sensory perception (GO:0007600)2.42282114
164protein localization to cilium (GO:0061512)2.41902545
165regulation of dopamine metabolic process (GO:0042053)2.41216047
166regulation of catecholamine metabolic process (GO:0042069)2.41216047
167electron transport chain (GO:0022900)2.40385670
168respiratory electron transport chain (GO:0022904)2.40090007
169gamma-aminobutyric acid signaling pathway (GO:0007214)2.39939319
170mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.37916430
171synaptic transmission, dopaminergic (GO:0001963)2.37281971
172negative regulation of neurotransmitter transport (GO:0051589)2.36571067
173L-fucose catabolic process (GO:0042355)2.35247695
174fucose catabolic process (GO:0019317)2.35247695
175L-fucose metabolic process (GO:0042354)2.35247695
176L-amino acid import (GO:0043092)2.34441407
177cell morphogenesis involved in neuron differentiation (GO:0048667)2.34023181
178behavioral response to cocaine (GO:0048148)2.31421325
179estrogen biosynthetic process (GO:0006703)2.31362430
180sphingoid metabolic process (GO:0046519)2.31008921
181short-term memory (GO:0007614)2.30927968
182left/right axis specification (GO:0070986)2.29406469
183positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.25606958
184calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.25122159
185regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.23894187

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.32615565
2ZNF274_21170338_ChIP-Seq_K562_Hela3.59603388
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27172183
4GBX2_23144817_ChIP-Seq_PC3_Human3.01241180
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94050453
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.80139632
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76558140
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73701922
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67512323
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.65198158
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.63474700
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61782534
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.53386873
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.43068884
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41806749
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.40442831
17TAF15_26573619_Chip-Seq_HEK293_Human2.39931013
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38464075
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38464075
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37203102
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.32727973
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27541041
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23248305
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17700610
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.14487750
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14080638
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.12779127
28* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.06763363
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06353529
30MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03945549
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.97925089
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95983926
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94592820
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93623676
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89373897
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88852840
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87619783
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87479516
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84487353
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82561504
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80323832
42AR_21572438_ChIP-Seq_LNCaP_Human1.79853628
43EWS_26573619_Chip-Seq_HEK293_Human1.79482088
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79261446
45VDR_22108803_ChIP-Seq_LS180_Human1.79169450
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78803714
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72832673
48P300_19829295_ChIP-Seq_ESCs_Human1.71730209
49IGF1R_20145208_ChIP-Seq_DFB_Human1.71601450
50RNF2_27304074_Chip-Seq_NSC_Mouse1.70733969
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70099796
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.69670062
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68485029
54DROSHA_22980978_ChIP-Seq_HELA_Human1.67350808
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66706071
56ELK1_19687146_ChIP-ChIP_HELA_Human1.62628588
57IRF1_19129219_ChIP-ChIP_H3396_Human1.62419084
58VDR_23849224_ChIP-Seq_CD4+_Human1.60297443
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.58497523
60REST_21632747_ChIP-Seq_MESCs_Mouse1.56657258
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.54103578
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.53771187
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.49967142
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45506919
65ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44768127
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42293123
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42276341
68MYC_18940864_ChIP-ChIP_HL60_Human1.41208657
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40656760
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40157112
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38399690
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36981291
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.35773318
74SMAD4_21799915_ChIP-Seq_A2780_Human1.35524835
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.34289280
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33017092
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30196291
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29568081
79FUS_26573619_Chip-Seq_HEK293_Human1.28379268
80* XRN2_22483619_ChIP-Seq_HELA_Human1.26960239
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26880913
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26551804
83CIITA_25753668_ChIP-Seq_RAJI_Human1.26084680
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25732028
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25476623
86CBP_20019798_ChIP-Seq_JUKART_Human1.25476623
87CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25409893
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.25089924
89* GABP_19822575_ChIP-Seq_HepG2_Human1.23769344
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23376976
91FOXP3_21729870_ChIP-Seq_TREG_Human1.23337553
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21034134
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21002361
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.20582503
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.18868268
96TP53_22573176_ChIP-Seq_HFKS_Human1.17919584
97FLI1_27457419_Chip-Seq_LIVER_Mouse1.17251847
98ERA_21632823_ChIP-Seq_H3396_Human1.16908659
99NCOR_22424771_ChIP-Seq_293T_Human1.16686318
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15705308
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15281921
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15207765
103RUNX2_22187159_ChIP-Seq_PCA_Human1.14535994
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14400363
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14107304
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12274209
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12050706
108AHR_22903824_ChIP-Seq_MCF-7_Human1.10968999
109ER_23166858_ChIP-Seq_MCF-7_Human1.10697142
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10257284
111PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10250678
112ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10085119
113AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09896655
114E2F1_18555785_Chip-Seq_ESCs_Mouse1.08806562
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.08459127
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07768249
117TTF2_22483619_ChIP-Seq_HELA_Human1.07500510
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06913187
119TP53_18474530_ChIP-ChIP_U2OS_Human1.06871822
120MYC_19829295_ChIP-Seq_ESCs_Human1.06715572
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.06385978
122TP63_17297297_ChIP-ChIP_HaCaT_Human1.06216298
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05198429
124SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05097078
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04838713
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04838713
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04131922
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03718203
129REST_18959480_ChIP-ChIP_MESCs_Mouse1.03612913
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03416173
131TP63_19390658_ChIP-ChIP_HaCaT_Human1.02584309
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01952618
133CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01526695
134P53_22387025_ChIP-Seq_ESCs_Mouse1.01279685
135P300_18555785_Chip-Seq_ESCs_Mouse1.00662052
136POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00096527
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99964649
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.99504979
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99061444
140TP53_20018659_ChIP-ChIP_R1E_Mouse0.98598692
141SMAD_19615063_ChIP-ChIP_OVARY_Human0.98085596
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.97246907
143P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97207771
144KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96426868
145SOX2_18555785_Chip-Seq_ESCs_Mouse0.96341707
146NANOG_20526341_ChIP-Seq_ESCs_Human0.95875636
147AR_20517297_ChIP-Seq_VCAP_Human0.95590056
148AR_25329375_ChIP-Seq_VCAP_Human0.95239016
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94530720
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94076740
151TAL1_26923725_Chip-Seq_HPCs_Mouse0.93873143
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93744911
153FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93526431
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.93523525
155RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93506986
156PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92334403
157ERG_20517297_ChIP-Seq_VCAP_Human0.92157641
158STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91633563
159EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91415845
160NMYC_18555785_Chip-Seq_ESCs_Mouse0.91106051
161FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90778701
162FOXA1_25329375_ChIP-Seq_VCAP_Human0.90778701
163OCT4_20526341_ChIP-Seq_ESCs_Human0.90195101
164RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90176848
165KDM2B_26808549_Chip-Seq_REH_Human0.90052798
166GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89879488
167SOX2_19829295_ChIP-Seq_ESCs_Human0.87204454
168NANOG_19829295_ChIP-Seq_ESCs_Human0.87204454
169YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86858083
170HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85684501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.42437486
2MP0003011_delayed_dark_adaptation4.13119159
3MP0005423_abnormal_somatic_nervous4.11362535
4MP0006072_abnormal_retinal_apoptosis3.92063333
5MP0005253_abnormal_eye_physiology3.53624907
6MP0003136_yellow_coat_color3.40306002
7MP0003880_abnormal_central_pattern3.16415355
8MP0003122_maternal_imprinting3.03392596
9MP0002822_catalepsy2.74754141
10MP0005410_abnormal_fertilization2.69714150
11MP0005645_abnormal_hypothalamus_physiol2.50145199
12MP0002234_abnormal_pharynx_morphology2.44760234
13MP0004270_analgesia2.42425744
14MP0003950_abnormal_plasma_membrane2.42154884
15MP0008789_abnormal_olfactory_epithelium2.37842796
16MP0005195_abnormal_posterior_eye2.35162041
17MP0001984_abnormal_olfaction2.34566053
18MP0000778_abnormal_nervous_system2.06544442
19MP0005499_abnormal_olfactory_system2.05918117
20MP0005394_taste/olfaction_phenotype2.05918117
21MP0003646_muscle_fatigue2.01373257
22MP0001486_abnormal_startle_reflex1.98431248
23MP0004885_abnormal_endolymph1.96223541
24MP0002752_abnormal_somatic_nervous1.92863744
25MP0004742_abnormal_vestibular_system1.92218926
26MP0001346_abnormal_lacrimal_gland1.89495651
27MP0002638_abnormal_pupillary_reflex1.87875322
28MP0002229_neurodegeneration1.81228445
29MP0005391_vision/eye_phenotype1.78817958
30MP0001324_abnormal_eye_pigmentation1.77266677
31MP0004381_abnormal_hair_follicle1.76789487
32MP0004133_heterotaxia1.76271209
33MP0002090_abnormal_vision1.76004538
34MP0006276_abnormal_autonomic_nervous1.75027578
35MP0002272_abnormal_nervous_system1.74962222
36MP0002735_abnormal_chemical_nociception1.73602262
37MP0000569_abnormal_digit_pigmentation1.72398633
38MP0002882_abnormal_neuron_morphology1.68731888
39MP0001501_abnormal_sleep_pattern1.66824958
40MP0005409_darkened_coat_color1.66619433
41MP0005084_abnormal_gallbladder_morpholo1.65181084
42MP0001502_abnormal_circadian_rhythm1.64827257
43MP0002254_reproductive_system_inflammat1.64333141
44MP0003121_genomic_imprinting1.64268120
45MP0008877_abnormal_DNA_methylation1.57804005
46MP0003635_abnormal_synaptic_transmissio1.54743799
47MP0000049_abnormal_middle_ear1.54504999
48MP0002064_seizures1.53086066
49MP0000631_abnormal_neuroendocrine_gland1.50685888
50MP0002282_abnormal_trachea_morphology1.50090370
51MP0002184_abnormal_innervation1.49040878
52MP0009379_abnormal_foot_pigmentation1.46823931
53MP0001485_abnormal_pinna_reflex1.46168140
54MP0002734_abnormal_mechanical_nocicepti1.46039518
55MP0002837_dystrophic_cardiac_calcinosis1.45728261
56MP0003634_abnormal_glial_cell1.45442241
57MP0003698_abnormal_male_reproductive1.39361702
58MP0001529_abnormal_vocalization1.38136238
59MP0000920_abnormal_myelination1.35508474
60MP0002653_abnormal_ependyma_morphology1.34568550
61MP0003787_abnormal_imprinting1.32725641
62MP0001986_abnormal_taste_sensitivity1.32375026
63MP0009046_muscle_twitch1.32119123
64MP0001905_abnormal_dopamine_level1.30911527
65MP0005171_absent_coat_pigmentation1.29554602
66MP0008995_early_reproductive_senescence1.29513166
67MP0008058_abnormal_DNA_repair1.28021681
68MP0001293_anophthalmia1.24790522
69MP0000372_irregular_coat_pigmentation1.24434225
70MP0009745_abnormal_behavioral_response1.24282558
71MP0002928_abnormal_bile_duct1.23778456
72MP0001968_abnormal_touch/_nociception1.22677115
73MP0002736_abnormal_nociception_after1.21890903
74MP0002063_abnormal_learning/memory/cond1.18669259
75MP0008260_abnormal_autophagy1.18051572
76MP0002572_abnormal_emotion/affect_behav1.17842633
77MP0001929_abnormal_gametogenesis1.15661290
78MP0006292_abnormal_olfactory_placode1.15184997
79MP0001440_abnormal_grooming_behavior1.14949545
80MP0002557_abnormal_social/conspecific_i1.14722395
81MP0002067_abnormal_sensory_capabilities1.14240194
82MP0000026_abnormal_inner_ear1.13767175
83MP0002249_abnormal_larynx_morphology1.12626154
84MP0001963_abnormal_hearing_physiology1.12611322
85MP0005248_abnormal_Harderian_gland1.09250512
86MP0001188_hyperpigmentation1.08193225
87MP0001764_abnormal_homeostasis1.06646112
88MP0004142_abnormal_muscle_tone1.06355444
89MP0002796_impaired_skin_barrier1.05452649
90MP0001970_abnormal_pain_threshold1.00405915
91MP0002938_white_spotting1.00354504
92MP0003119_abnormal_digestive_system0.95384782
93MP0004811_abnormal_neuron_physiology0.94794078
94MP0002102_abnormal_ear_morphology0.94707900
95MP0005085_abnormal_gallbladder_physiolo0.91990820
96MP0004859_abnormal_synaptic_plasticity0.90812442
97MP0006035_abnormal_mitochondrial_morpho0.90377839
98MP0010030_abnormal_orbit_morphology0.88716257
99MP0003937_abnormal_limbs/digits/tail_de0.86266867
100MP0004145_abnormal_muscle_electrophysio0.84137979
101MP0002152_abnormal_brain_morphology0.84119762
102MP0000462_abnormal_digestive_system0.84044528
103MP0002909_abnormal_adrenal_gland0.82960428
104MP0004215_abnormal_myocardial_fiber0.82444173
105MP0010386_abnormal_urinary_bladder0.81638488
106MP0008569_lethality_at_weaning0.79923011
107MP0002277_abnormal_respiratory_mucosa0.79506175
108MP0002161_abnormal_fertility/fecundity0.78073524
109MP0009250_abnormal_appendicular_skeleto0.77077259
110MP0002733_abnormal_thermal_nociception0.76965905
111MP0000762_abnormal_tongue_morphology0.76725754
112MP0003718_maternal_effect0.75891262
113MP0000383_abnormal_hair_follicle0.75695683
114MP0002210_abnormal_sex_determination0.75624742
115MP0000955_abnormal_spinal_cord0.75142149
116MP0001727_abnormal_embryo_implantation0.74888147
117MP0002066_abnormal_motor_capabilities/c0.74459825
118MP0005377_hearing/vestibular/ear_phenot0.73685370
119MP0003878_abnormal_ear_physiology0.73685370
120MP0005386_behavior/neurological_phenoty0.73556706
121MP0004924_abnormal_behavior0.73556706
122MP0002160_abnormal_reproductive_system0.73031247
123MP0002127_abnormal_cardiovascular_syste0.73013633
124MP0005623_abnormal_meninges_morphology0.70985158
125MP0005646_abnormal_pituitary_gland0.68567004
126MP0001661_extended_life_span0.67670611
127MP0003633_abnormal_nervous_system0.65442848
128MP0002877_abnormal_melanocyte_morpholog0.65203534
129MP0002332_abnormal_exercise_endurance0.64597976
130MP0002751_abnormal_autonomic_nervous0.63688281
131MP0003183_abnormal_peptide_metabolism0.63615451
132MP0002876_abnormal_thyroid_physiology0.63375695
133MP0002233_abnormal_nose_morphology0.63029850
134MP0010678_abnormal_skin_adnexa0.62903377
135MP0003137_abnormal_impulse_conducting0.62665035
136MP0003690_abnormal_glial_cell0.61965814
137MP0003938_abnormal_ear_development0.60586674

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)9.21195824
2Bony spicule pigmentary retinopathy (HP:0007737)7.47101805
3Abnormal rod and cone electroretinograms (HP:0008323)6.56202000
4Absent rod-and cone-mediated responses on ERG (HP:0007688)6.16658059
5Pendular nystagmus (HP:0012043)5.38402882
6Abolished electroretinogram (ERG) (HP:0000550)5.34769554
7Chorioretinal atrophy (HP:0000533)5.34613357
8Attenuation of retinal blood vessels (HP:0007843)5.25121713
9Abnormality of macular pigmentation (HP:0008002)4.85115062
10Pigmentary retinal degeneration (HP:0001146)4.82937408
11Central scotoma (HP:0000603)4.78357131
12Dyschromatopsia (HP:0007641)4.73093621
13Decreased central vision (HP:0007663)4.39315158
14Increased corneal curvature (HP:0100692)4.30786686
15Keratoconus (HP:0000563)4.30786686
16Hyperglycinemia (HP:0002154)4.09945580
17Scotoma (HP:0000575)4.01384201
18Photophobia (HP:0000613)3.55437046
19Pancreatic fibrosis (HP:0100732)3.52967511
20Parakeratosis (HP:0001036)3.52501744
21Retinitis pigmentosa (HP:0000510)3.44505120
22Pancreatic cysts (HP:0001737)3.43577155
23Vitreoretinal degeneration (HP:0000655)3.30477292
24Type II diabetes mellitus (HP:0005978)3.17856924
25Cone-rod dystrophy (HP:0000548)3.14344151
26Optic disc pallor (HP:0000543)3.11431128
27Severe visual impairment (HP:0001141)3.03919925
28Abnormal ciliary motility (HP:0012262)2.98696589
29Nephronophthisis (HP:0000090)2.96212696
30Specific learning disability (HP:0001328)2.94991567
31Abnormality of midbrain morphology (HP:0002418)2.88067618
32Molar tooth sign on MRI (HP:0002419)2.88067618
33Abnormality of glycine metabolism (HP:0010895)2.85344491
34Abnormality of serine family amino acid metabolism (HP:0010894)2.85344491
35Mitochondrial inheritance (HP:0001427)2.80549420
36Gait imbalance (HP:0002141)2.76867620
37Occipital encephalocele (HP:0002085)2.74188280
38Medial flaring of the eyebrow (HP:0010747)2.67921933
39Abnormal respiratory motile cilium physiology (HP:0012261)2.67846660
40Increased hepatocellular lipid droplets (HP:0006565)2.67078856
41Choroideremia (HP:0001139)2.66882406
42Type II lissencephaly (HP:0007260)2.65349822
43Hepatocellular necrosis (HP:0001404)2.61334231
44Macular degeneration (HP:0000608)2.61054147
45Lissencephaly (HP:0001339)2.61001365
46Congenital malformation of the right heart (HP:0011723)2.60921435
47Double outlet right ventricle (HP:0001719)2.60921435
48Rib fusion (HP:0000902)2.57801720
49Congenital primary aphakia (HP:0007707)2.57764300
50Cortical dysplasia (HP:0002539)2.56793131
51Type I transferrin isoform profile (HP:0003642)2.55562641
52Hyperglycinuria (HP:0003108)2.55117227
53Hepatic necrosis (HP:0002605)2.54873491
54Abnormal protein glycosylation (HP:0012346)2.53029096
55Abnormal glycosylation (HP:0012345)2.53029096
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.53029096
57Abnormal protein N-linked glycosylation (HP:0012347)2.53029096
58Abnormality of the renal medulla (HP:0100957)2.50138782
59Increased CSF lactate (HP:0002490)2.49091786
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47645348
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.47645348
62Retinal dysplasia (HP:0007973)2.41462144
63Abnormal mitochondria in muscle tissue (HP:0008316)2.41141188
64Lipid accumulation in hepatocytes (HP:0006561)2.41071168
65Short tibia (HP:0005736)2.40791717
66Polyphagia (HP:0002591)2.40665192
67Acute encephalopathy (HP:0006846)2.39184213
68Chronic hepatic failure (HP:0100626)2.38910730
69Vaginal atresia (HP:0000148)2.38292780
70Methylmalonic acidemia (HP:0002912)2.37540050
71Genital tract atresia (HP:0001827)2.33592533
72Neurofibrillary tangles (HP:0002185)2.32785163
73Nephrogenic diabetes insipidus (HP:0009806)2.32064244
74Decreased testicular size (HP:0008734)2.30913671
75Methylmalonic aciduria (HP:0012120)2.30748797
76Broad foot (HP:0001769)2.30096957
77Aplasia cutis congenita (HP:0001057)2.27363240
78Septo-optic dysplasia (HP:0100842)2.26603888
79Inability to walk (HP:0002540)2.24128587
80Abnormal biliary tract physiology (HP:0012439)2.22653012
81Bile duct proliferation (HP:0001408)2.22653012
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.21943173
83Cystic liver disease (HP:0006706)2.21554452
84Postaxial foot polydactyly (HP:0001830)2.21107617
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19409820
86Pachygyria (HP:0001302)2.17919497
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16657699
88Progressive inability to walk (HP:0002505)2.15161342
89Anencephaly (HP:0002323)2.15092878
90Constricted visual fields (HP:0001133)2.15010951
91Epileptic encephalopathy (HP:0200134)2.13852719
92Tubulointerstitial nephritis (HP:0001970)2.13775717
93Abnormality of secondary sexual hair (HP:0009888)2.12025613
94Abnormality of the axillary hair (HP:0100134)2.12025613
95Cerebellar dysplasia (HP:0007033)2.11817044
96Postaxial hand polydactyly (HP:0001162)2.10674510
97Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09039490
98Aplasia/Hypoplasia of the brainstem (HP:0007362)2.06254516
99Hypoplasia of the brainstem (HP:0002365)2.06254516
100True hermaphroditism (HP:0010459)2.03048857
101Renal dysplasia (HP:0000110)2.02274383
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.02013912
103Aplasia/Hypoplasia of the lens (HP:0008063)2.00299288
104Shoulder girdle muscle weakness (HP:0003547)1.97788639
105White forelock (HP:0002211)1.96760679
106Generalized aminoaciduria (HP:0002909)1.96648724
107Submucous cleft hard palate (HP:0000176)1.95851771
108Amblyopia (HP:0000646)1.93605111
109Drooling (HP:0002307)1.93249425
110Sensory axonal neuropathy (HP:0003390)1.92774959
111Abnormality of the corticospinal tract (HP:0002492)1.92759299
112Congenital hepatic fibrosis (HP:0002612)1.91886660
113Rimmed vacuoles (HP:0003805)1.91536304
114Septate vagina (HP:0001153)1.91306316
115Renal cortical cysts (HP:0000803)1.91124747
116Split foot (HP:0001839)1.91019455
117Congenital ichthyosiform erythroderma (HP:0007431)1.90124723
118Abnormality of serum amino acid levels (HP:0003112)1.89776621
119Abnormal respiratory motile cilium morphology (HP:0005938)1.89767929
120Abnormal respiratory epithelium morphology (HP:0012253)1.89767929
121Anophthalmia (HP:0000528)1.89135715
122Congenital sensorineural hearing impairment (HP:0008527)1.88893398
123Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88159031
124Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88159031
125Abnormal sex determination (HP:0012244)1.86734661
126Sex reversal (HP:0012245)1.86734661
127Esotropia (HP:0000565)1.86212825
128Spastic tetraplegia (HP:0002510)1.86092743
129Preaxial hand polydactyly (HP:0001177)1.85208441
130Absent/shortened dynein arms (HP:0200106)1.84249014
131Dynein arm defect of respiratory motile cilia (HP:0012255)1.84249014
132Cerebral edema (HP:0002181)1.83436243
133Atrophy/Degeneration involving motor neurons (HP:0007373)1.83067662
134Amyotrophic lateral sclerosis (HP:0007354)1.81907612
135Patchy hypopigmentation of hair (HP:0011365)1.81365255
136Abnormality of the lower motor neuron (HP:0002366)1.80879096
137Sclerocornea (HP:0000647)1.79273006
138Degeneration of anterior horn cells (HP:0002398)1.79033148
139Abnormality of the anterior horn cell (HP:0006802)1.79033148
140Optic nerve coloboma (HP:0000588)1.78868076
141Cerebral inclusion bodies (HP:0100314)1.78337248
142Increased intramyocellular lipid droplets (HP:0012240)1.78169471
143Febrile seizures (HP:0002373)1.78037631
144Severe Myopia (HP:0011003)1.74768048
145Progressive cerebellar ataxia (HP:0002073)1.73960255
146Abnormal hair whorl (HP:0010721)1.72518990
147Anosmia (HP:0000458)1.70295064
148Poor coordination (HP:0002370)1.68917701
149Hypothermia (HP:0002045)1.68895685
150Supranuclear gaze palsy (HP:0000605)1.68496956
151Rhinitis (HP:0012384)1.67362659
152Aplasia involving bones of the upper limbs (HP:0009823)1.65996686
153Aplasia of the phalanges of the hand (HP:0009802)1.65996686
154Aplasia involving bones of the extremities (HP:0009825)1.65996686
155Acute necrotizing encephalopathy (HP:0006965)1.65559044
156Hemiparesis (HP:0001269)1.65291647
157Metabolic alkalosis (HP:0200114)1.63339772
158Dysdiadochokinesis (HP:0002075)1.62735326
159Focal seizures (HP:0007359)1.62341934
160Xerostomia (HP:0000217)1.62244317
161Hypoplastic pelvis (HP:0008839)1.60699545
162Renal Fanconi syndrome (HP:0001994)1.60015040
163Myelomeningocele (HP:0002475)1.59660639
164Limb dystonia (HP:0002451)1.58631866
165Peripheral hypomyelination (HP:0007182)1.58550668
166Hypoplastic left heart (HP:0004383)1.58055846
167Progressive visual loss (HP:0000529)1.57980830
168Generalized myoclonic seizures (HP:0002123)1.56968373
169Partial agenesis of the corpus callosum (HP:0001338)1.56103526
170Absent eyebrow (HP:0002223)1.55457864
171Focal motor seizures (HP:0011153)1.55328659
172Abnormality of renal resorption (HP:0011038)1.55104765
173Progressive macrocephaly (HP:0004481)1.54180815
174Lip pit (HP:0100267)1.51292245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.79331316
2GRK13.73234868
3CASK3.38474813
4PBK3.27698816
5WNK33.25774481
6MAP4K22.99989718
7IRAK22.90802132
8STK392.76073859
9TRIM282.67701929
10BCKDK2.67338166
11DYRK32.58218833
12PLK42.14979432
13ARAF2.12760439
14RPS6KA42.11068034
15ZAK2.01394561
16OXSR11.98187975
17PINK11.96420105
18TESK21.93913393
19PNCK1.88715292
20MARK11.83438791
21GRK51.75163419
22EPHA31.68974227
23CCNB11.67572379
24MAPK151.61563915
25SIK31.59365152
26TAF11.53914402
27VRK21.53825268
28NTRK11.52410787
29GRK71.45647181
30PKN11.42981136
31MAPK131.41561958
32BCR1.41083053
33PHKG21.40140676
34PHKG11.40140676
35NTRK21.36403302
36DYRK1B1.35370529
37MAP3K121.33472169
38EPHA41.27723563
39BMPR1B1.27353738
40VRK11.19156432
41BMPR21.18640708
42IRAK11.15247874
43PAK61.14841070
44MST41.14111583
45NTRK31.13840071
46MAP3K21.12666050
47UHMK11.09076568
48CAMK2D1.08880871
49WNK41.06390130
50FES1.05710637
51MAPKAPK51.04822349
52EPHB21.02414664
53DYRK21.01241670
54CAMK2B0.97272010
55ADRBK10.96971697
56CSNK1A1L0.95681140
57SIK20.95545084
58BLK0.95472587
59CAMK2A0.94169978
60NUAK10.92405694
61PIM20.92286544
62FRK0.90271143
63DYRK1A0.90003831
64SRPK10.87060738
65MAP2K70.85537287
66MAP3K130.84377179
67PRKCE0.84219043
68IRAK40.83823601
69PAK30.83005924
70YES10.82996262
71WNK10.82237515
72NME10.81742541
73CSNK1G20.80953830
74CSNK1G30.79695915
75MKNK20.79616081
76PLK20.79137921
77FGR0.78700263
78ERBB20.77839870
79NEK60.77353813
80CDK190.77204303
81RIPK40.76679991
82RPS6KA50.75970597
83PRKCG0.75447337
84MAP2K20.75147681
85BRAF0.73692410
86LIMK10.73276916
87MINK10.72547192
88ROCK20.70681787
89PTK2B0.68135670
90SGK2230.65949223
91SGK4940.65949223
92TLK10.65695673
93CAMK2G0.65310369
94MAP3K10.64886368
95KDR0.62385237
96CDK140.61932532
97TIE10.60170986
98CDK11A0.59628164
99MARK20.57425993
100MAP3K40.56709357
101PLK30.55696681
102CDK180.54999485
103PLK10.54608506
104ADRBK20.54217938
105MET0.53018909
106CSNK1D0.52511171
107DAPK20.52061570
108CSNK1G10.51875559
109CDK30.51584082
110MAPK120.51209066
111TESK10.50360590
112CDK150.49920533
113CDK50.49474199
114CAMKK20.49410608
115MUSK0.49027072
116PRPF4B0.48504474
117AURKA0.48467099
118PRKACA0.48454967
119PRKCQ0.48095103
120MAP2K40.46395138
121CSNK1A10.46142912
122NLK0.45073918
123PRKG10.44647817
124INSRR0.44152850
125RAF10.43666131
126FER0.43502607
127PIK3CA0.41721746
128ERBB30.41510141
129KSR10.40766470
130TAOK30.40330387
131ATR0.39338914
132MKNK10.39328999
133MST1R0.38731305
134FYN0.38492838
135STK160.38167133
136MAPK70.38134600
137FLT30.37474144
138PASK0.36879020
139PIK3CG0.35916291
140TGFBR10.35760748
141BUB10.35529197
142EPHB10.34407015
143CSNK2A10.31378470
144CAMK40.30241920
145AURKB0.29038154
146PRKACB0.28842003

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047449.97876995
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.66732235
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.66447052
4Nicotine addiction_Homo sapiens_hsa050332.37173021
5Oxidative phosphorylation_Homo sapiens_hsa001902.06308932
6GABAergic synapse_Homo sapiens_hsa047271.98553606
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98468988
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96110828
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.92822763
10Butanoate metabolism_Homo sapiens_hsa006501.91948321
11Serotonergic synapse_Homo sapiens_hsa047261.89330676
12Olfactory transduction_Homo sapiens_hsa047401.89001885
13Glutamatergic synapse_Homo sapiens_hsa047241.75762304
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72559698
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.66525233
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65798059
17Morphine addiction_Homo sapiens_hsa050321.65533232
18Alzheimers disease_Homo sapiens_hsa050101.60540530
19Peroxisome_Homo sapiens_hsa041461.59046772
20Steroid biosynthesis_Homo sapiens_hsa001001.58880217
21Synaptic vesicle cycle_Homo sapiens_hsa047211.51018987
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50751597
23Circadian entrainment_Homo sapiens_hsa047131.47683092
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.42082547
25Axon guidance_Homo sapiens_hsa043601.41772614
26Sphingolipid metabolism_Homo sapiens_hsa006001.39582574
27Sulfur relay system_Homo sapiens_hsa041221.38968402
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38848832
29Base excision repair_Homo sapiens_hsa034101.35632557
30Cholinergic synapse_Homo sapiens_hsa047251.35623213
31RNA polymerase_Homo sapiens_hsa030201.30072027
32Dopaminergic synapse_Homo sapiens_hsa047281.29917255
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.29586830
34Parkinsons disease_Homo sapiens_hsa050121.29017361
35Ether lipid metabolism_Homo sapiens_hsa005651.28620472
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24887954
37Basal transcription factors_Homo sapiens_hsa030221.20908324
38Salivary secretion_Homo sapiens_hsa049701.20080660
39Cardiac muscle contraction_Homo sapiens_hsa042601.19241242
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15778647
41beta-Alanine metabolism_Homo sapiens_hsa004101.15774245
42Taste transduction_Homo sapiens_hsa047421.14139763
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13673298
44Tryptophan metabolism_Homo sapiens_hsa003801.12870229
45Collecting duct acid secretion_Homo sapiens_hsa049661.11932973
46Fanconi anemia pathway_Homo sapiens_hsa034601.11547717
47Amphetamine addiction_Homo sapiens_hsa050311.10631893
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10323971
49Fatty acid elongation_Homo sapiens_hsa000621.09998827
50Huntingtons disease_Homo sapiens_hsa050161.07662981
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07280981
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06491115
53Spliceosome_Homo sapiens_hsa030401.03254137
54Biosynthesis of amino acids_Homo sapiens_hsa012301.02918449
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02801250
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01675550
57Selenocompound metabolism_Homo sapiens_hsa004501.00312420
58Insulin secretion_Homo sapiens_hsa049110.99972045
59RNA degradation_Homo sapiens_hsa030180.98340410
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97938521
61Renin secretion_Homo sapiens_hsa049240.92348368
62Pyruvate metabolism_Homo sapiens_hsa006200.91879215
63Dorso-ventral axis formation_Homo sapiens_hsa043200.91780853
64Proteasome_Homo sapiens_hsa030500.90895891
65Propanoate metabolism_Homo sapiens_hsa006400.90741336
66Long-term potentiation_Homo sapiens_hsa047200.89656885
67Long-term depression_Homo sapiens_hsa047300.88273478
68Fructose and mannose metabolism_Homo sapiens_hsa000510.88121956
69Cocaine addiction_Homo sapiens_hsa050300.87708759
70Metabolic pathways_Homo sapiens_hsa011000.87255942
71Fatty acid metabolism_Homo sapiens_hsa012120.86521093
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86242398
73Mismatch repair_Homo sapiens_hsa034300.84625230
74RNA transport_Homo sapiens_hsa030130.84231154
75Retinol metabolism_Homo sapiens_hsa008300.83541895
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81444668
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.80969421
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80325311
79Linoleic acid metabolism_Homo sapiens_hsa005910.76296029
80Gastric acid secretion_Homo sapiens_hsa049710.76006532
81Calcium signaling pathway_Homo sapiens_hsa040200.74882612
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74278570
83Fatty acid degradation_Homo sapiens_hsa000710.73444948
84Protein export_Homo sapiens_hsa030600.72054088
85Homologous recombination_Homo sapiens_hsa034400.69918588
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69698626
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68081091
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67508240
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66687044
90Melanogenesis_Homo sapiens_hsa049160.65982828
91Phenylalanine metabolism_Homo sapiens_hsa003600.65963895
92Purine metabolism_Homo sapiens_hsa002300.65942885
93GnRH signaling pathway_Homo sapiens_hsa049120.65129976
94Nitrogen metabolism_Homo sapiens_hsa009100.65115705
95Arachidonic acid metabolism_Homo sapiens_hsa005900.64252872
96Sulfur metabolism_Homo sapiens_hsa009200.62776619
97Alcoholism_Homo sapiens_hsa050340.62758272
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62665858
99Ras signaling pathway_Homo sapiens_hsa040140.61314870
100Oxytocin signaling pathway_Homo sapiens_hsa049210.61041158
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60451298
102Carbon metabolism_Homo sapiens_hsa012000.58926916
103Circadian rhythm_Homo sapiens_hsa047100.58874550
104Pancreatic secretion_Homo sapiens_hsa049720.58521031
105ABC transporters_Homo sapiens_hsa020100.58362117
106Nucleotide excision repair_Homo sapiens_hsa034200.57598455
107cAMP signaling pathway_Homo sapiens_hsa040240.57516444
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56516740
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56180384
110Mineral absorption_Homo sapiens_hsa049780.55411812
111Pyrimidine metabolism_Homo sapiens_hsa002400.54386330
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53390626
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53176214
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.51751344
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.51520352
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51104269
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49427188
118Rheumatoid arthritis_Homo sapiens_hsa053230.48769208
119Histidine metabolism_Homo sapiens_hsa003400.48517840
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48043250
121Choline metabolism in cancer_Homo sapiens_hsa052310.47707196
122Basal cell carcinoma_Homo sapiens_hsa052170.47061384
123Fat digestion and absorption_Homo sapiens_hsa049750.46066095
124mRNA surveillance pathway_Homo sapiens_hsa030150.44472756
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44224237
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44036014
127Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43589609
128ErbB signaling pathway_Homo sapiens_hsa040120.43585161
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43440960
130Hedgehog signaling pathway_Homo sapiens_hsa043400.42842350
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41799383
132Melanoma_Homo sapiens_hsa052180.41047652
133Regulation of autophagy_Homo sapiens_hsa041400.40345591
134Fatty acid biosynthesis_Homo sapiens_hsa000610.39321046
135Ribosome_Homo sapiens_hsa030100.39252405
136Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38904954
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38130327
138Renal cell carcinoma_Homo sapiens_hsa052110.37793374
139Arginine and proline metabolism_Homo sapiens_hsa003300.37361861
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.36752738
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36737360
142Wnt signaling pathway_Homo sapiens_hsa043100.36689299
143DNA replication_Homo sapiens_hsa030300.36482349
144Glutathione metabolism_Homo sapiens_hsa004800.35838066
145Vibrio cholerae infection_Homo sapiens_hsa051100.35107816
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34537160
147Tight junction_Homo sapiens_hsa045300.30099775
148MAPK signaling pathway_Homo sapiens_hsa040100.29890092
149Tyrosine metabolism_Homo sapiens_hsa003500.29251582
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.27642743
151Gap junction_Homo sapiens_hsa045400.25785602
152Ovarian steroidogenesis_Homo sapiens_hsa049130.25380474
153Chemical carcinogenesis_Homo sapiens_hsa052040.25088473
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24158027

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