SERINC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.69040534
2axon ensheathment in central nervous system (GO:0032291)9.69040534
3fatty acid elongation (GO:0030497)6.83712794
4* ensheathment of neurons (GO:0007272)6.66245894
5* axon ensheathment (GO:0008366)6.66245894
6* myelination (GO:0042552)6.58254086
7anterior/posterior axis specification, embryo (GO:0008595)5.71953165
8negative regulation of activin receptor signaling pathway (GO:0032926)5.70464955
9regulation of mesoderm development (GO:2000380)5.59793602
10myelin maintenance (GO:0043217)5.38654460
11negative regulation of neurotransmitter secretion (GO:0046929)5.11679240
12phospholipid scrambling (GO:0017121)4.95909032
13peptidyl-tyrosine autophosphorylation (GO:0038083)4.92878764
14oligodendrocyte differentiation (GO:0048709)4.88614468
15anterior/posterior axis specification (GO:0009948)4.84585782
16somite rostral/caudal axis specification (GO:0032525)4.74207001
17long-chain fatty acid biosynthetic process (GO:0042759)4.51315013
18cell migration involved in gastrulation (GO:0042074)4.46472089
19keratinocyte development (GO:0003334)4.44776212
20dorsal/ventral axis specification (GO:0009950)4.41765715
21positive regulation of oligodendrocyte differentiation (GO:0048714)4.32312024
22adhesion of symbiont to host cell (GO:0044650)4.31764245
23virion attachment to host cell (GO:0019062)4.31764245
24photoreceptor cell differentiation (GO:0046530)4.16706786
25eye photoreceptor cell differentiation (GO:0001754)4.16706786
26regulation of activin receptor signaling pathway (GO:0032925)4.16224760
27asymmetric protein localization (GO:0008105)4.14539760
28glycerophospholipid catabolic process (GO:0046475)4.12926511
29platelet dense granule organization (GO:0060155)4.09935457
30DNA double-strand break processing (GO:0000729)4.08859740
31negative regulation of neurotransmitter transport (GO:0051589)4.07532406
32creatine metabolic process (GO:0006600)4.02638407
33astrocyte development (GO:0014002)4.02114619
34endoderm formation (GO:0001706)3.98146271
35embryonic axis specification (GO:0000578)3.97523790
36CENP-A containing nucleosome assembly (GO:0034080)3.97167988
37DNA replication-dependent nucleosome organization (GO:0034723)3.92686315
38DNA replication-dependent nucleosome assembly (GO:0006335)3.92686315
39chromatin remodeling at centromere (GO:0031055)3.92367469
40peripheral nervous system axon ensheathment (GO:0032292)3.85819871
41myelination in peripheral nervous system (GO:0022011)3.85819871
42histone exchange (GO:0043486)3.82716022
43cholesterol biosynthetic process (GO:0006695)3.76511233
44apical protein localization (GO:0045176)3.75407883
45nodal signaling pathway (GO:0038092)3.73304211
46presynaptic membrane assembly (GO:0097105)3.71715823
47embryonic foregut morphogenesis (GO:0048617)3.68337819
48Rap protein signal transduction (GO:0032486)3.67724360
49negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.67226766
50regulation of translation, ncRNA-mediated (GO:0045974)3.67095457
51negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.67095457
52negative regulation of translation, ncRNA-mediated (GO:0040033)3.67095457
53limb bud formation (GO:0060174)3.65043254
54long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.63942628
55presynaptic membrane organization (GO:0097090)3.62824378
56signal transduction involved in regulation of gene expression (GO:0023019)3.61798057
57female gonad development (GO:0008585)3.61227537
58regulation of collateral sprouting (GO:0048670)3.60160468
59response to lipoprotein particle (GO:0055094)3.58633642
60regulation of cardioblast differentiation (GO:0051890)3.58017997
61embryonic pattern specification (GO:0009880)3.54608731
62adhesion of symbiont to host (GO:0044406)3.54349890
63negative regulation of protein localization to cell surface (GO:2000009)3.52559770
64RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.49827532
65response to pheromone (GO:0019236)3.49720930
66L-amino acid import (GO:0043092)3.49138120
67regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.46150859
68kidney morphogenesis (GO:0060993)3.45459174
69negative regulation of axon extension involved in axon guidance (GO:0048843)3.44243143
70positive regulation of action potential (GO:0045760)3.43956252
71protein localization to endosome (GO:0036010)3.43796809
72gastrulation (GO:0007369)3.37901919
73otic vesicle formation (GO:0030916)3.37865987
74proteasome assembly (GO:0043248)3.36057903
75import into cell (GO:0098657)3.35733436
76genitalia morphogenesis (GO:0035112)3.34117322
77substantia nigra development (GO:0021762)3.31873909
78primitive streak formation (GO:0090009)3.31869570
79positive regulation of protein autophosphorylation (GO:0031954)3.28586191
80cellular response to BMP stimulus (GO:0071773)3.28151764
81response to BMP (GO:0071772)3.28151764
82transmission of nerve impulse (GO:0019226)3.27118634
83negative regulation of axonogenesis (GO:0050771)3.26919152
84sterol biosynthetic process (GO:0016126)3.24637603
85regulation of acyl-CoA biosynthetic process (GO:0050812)3.22930879
86negative regulation of sodium ion transport (GO:0010766)3.21890445
87regulation of sulfur metabolic process (GO:0042762)3.20795515
88fatty-acyl-CoA biosynthetic process (GO:0046949)3.20550900
89regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.20211353
90phospholipid homeostasis (GO:0055091)3.14286028
91response to redox state (GO:0051775)3.13825594
92regulation of keratinocyte proliferation (GO:0010837)3.13402620
93sequestering of extracellular ligand from receptor (GO:0035581)3.12177639
94positive regulation of glycoprotein biosynthetic process (GO:0010560)3.10585641
95regulation of cofactor metabolic process (GO:0051193)3.07477831
96regulation of coenzyme metabolic process (GO:0051196)3.07477831
97long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.06757024
98protein palmitoylation (GO:0018345)3.05791687
99establishment of mitochondrion localization (GO:0051654)3.05194629
100peptidyl-cysteine modification (GO:0018198)3.03466880
101branched-chain amino acid catabolic process (GO:0009083)3.01297367
102replication fork processing (GO:0031297)3.01009915
103DNA deamination (GO:0045006)2.99878372
104Leydig cell differentiation (GO:0033327)2.99227563
105negative regulation of JUN kinase activity (GO:0043508)2.99168122
106positive regulation of glial cell differentiation (GO:0045687)2.98770098
107membrane tubulation (GO:0097320)2.98144058
108DNA replication-independent nucleosome assembly (GO:0006336)2.98092841
109DNA replication-independent nucleosome organization (GO:0034724)2.98092841
110response to methylmercury (GO:0051597)2.97245131
111amyloid precursor protein metabolic process (GO:0042982)2.96410768
112axis specification (GO:0009798)2.95059608
113atrial cardiac muscle cell action potential (GO:0086014)2.94560179
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.91355546
115peripheral nervous system development (GO:0007422)2.90907347
116histone mRNA catabolic process (GO:0071044)2.89983913
117cellular response to hepatocyte growth factor stimulus (GO:0035729)2.88425333
118response to hepatocyte growth factor (GO:0035728)2.88425333
119UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87525362
120negative regulation of keratinocyte proliferation (GO:0010839)2.86937875
121regulation of meiosis I (GO:0060631)2.86822510
122cytoskeletal anchoring at plasma membrane (GO:0007016)2.85825175
123positive regulation of cardiac muscle cell proliferation (GO:0060045)2.84973472
124lens fiber cell development (GO:0070307)2.84459382
125cerebral cortex radially oriented cell migration (GO:0021799)2.84235063
126adult walking behavior (GO:0007628)2.84120916
127very long-chain fatty acid metabolic process (GO:0000038)2.83602635
128glycosphingolipid biosynthetic process (GO:0006688)2.81982351
129negative regulation of axon guidance (GO:1902668)2.81977128
130cellular response to epinephrine stimulus (GO:0071872)2.81528189
131zinc ion transport (GO:0006829)2.81372567
132regulation of cell communication by electrical coupling (GO:0010649)2.81028789
133positive regulation of glycoprotein metabolic process (GO:1903020)2.79415559
134nerve growth factor signaling pathway (GO:0038180)2.78736085
135positive regulation of gliogenesis (GO:0014015)2.77142197
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.76581181
137negative regulation of axon extension (GO:0030517)2.76092925
138regulation of nuclear cell cycle DNA replication (GO:0033262)2.75175848
139neuron remodeling (GO:0016322)2.74829696
140L-phenylalanine catabolic process (GO:0006559)2.74615178
141erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.74615178
142branch elongation of an epithelium (GO:0060602)2.74446198
143interleukin-6-mediated signaling pathway (GO:0070102)2.73519843
144positive regulation of SMAD protein import into nucleus (GO:0060391)2.73223380
145membrane assembly (GO:0071709)2.72042280
146regulation of gastrulation (GO:0010470)2.71990191
147exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71523876
148histone H2A acetylation (GO:0043968)2.71170449
149fatty-acyl-CoA metabolic process (GO:0035337)2.70784807
150intestinal epithelial cell development (GO:0060576)2.70347458
151neurotransmitter catabolic process (GO:0042135)2.69605747
152glycosylceramide metabolic process (GO:0006677)2.68686523
153pericardium development (GO:0060039)2.68302315
154glial cell differentiation (GO:0010001)2.67418051
155amino acid import (GO:0043090)2.65823826
156somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.65603027
157isotype switching (GO:0045190)2.65603027
158somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.65603027
159magnesium ion transport (GO:0015693)2.65042175
160signal peptide processing (GO:0006465)2.63214294
161blastocyst development (GO:0001824)2.63048800
162axon development (GO:0061564)2.61123306
163nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.60781780
164double-strand break repair via nonhomologous end joining (GO:0006303)2.59964060
165non-recombinational repair (GO:0000726)2.59964060
166membrane protein ectodomain proteolysis (GO:0006509)2.59522094
167thioester biosynthetic process (GO:0035384)2.58586324
168acyl-CoA biosynthetic process (GO:0071616)2.58586324
169heme transport (GO:0015886)2.56605696
170leukocyte migration involved in inflammatory response (GO:0002523)2.56432612
171embryonic digestive tract morphogenesis (GO:0048557)2.56235834
172neuronal ion channel clustering (GO:0045161)2.55645736
173phospholipid efflux (GO:0033700)2.54956196
174positive regulation of cardiac muscle tissue growth (GO:0055023)2.54843785
175positive regulation of mRNA catabolic process (GO:0061014)2.54346485
176response to lead ion (GO:0010288)2.53680286
177histone mRNA metabolic process (GO:0008334)2.51693860
178regulation of extracellular matrix disassembly (GO:0010715)2.51455950
179cardiac right ventricle morphogenesis (GO:0003215)2.50507418
180nucleotide transmembrane transport (GO:1901679)2.50502191
181neuron cell-cell adhesion (GO:0007158)2.49251424
182cyclic nucleotide catabolic process (GO:0009214)2.49176739
183regulation of homotypic cell-cell adhesion (GO:0034110)2.48960585
184isoprenoid biosynthetic process (GO:0008299)2.48402538
185regulation of axon extension involved in axon guidance (GO:0048841)2.48333451
186organ growth (GO:0035265)2.47089121
187lateral sprouting from an epithelium (GO:0060601)2.46777382
188enteric nervous system development (GO:0048484)2.46648452
189Golgi to endosome transport (GO:0006895)2.46548978
190glial cell development (GO:0021782)2.42679418
191cortical actin cytoskeleton organization (GO:0030866)2.40276669
192ear development (GO:0043583)2.39954777
193dendrite morphogenesis (GO:0048813)2.37874185
194cerebellar granule cell differentiation (GO:0021707)2.37807858
195Golgi to plasma membrane protein transport (GO:0043001)2.37612209
196regulation of myelination (GO:0031641)2.35154624
197phosphatidylinositol 3-kinase signaling (GO:0014065)2.34888716
198cellular response to catecholamine stimulus (GO:0071870)2.34142372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.36327772
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.35876234
3GBX2_23144817_ChIP-Seq_PC3_Human2.76346901
4ZNF274_21170338_ChIP-Seq_K562_Hela2.62011626
5* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.51228026
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47340227
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.44009144
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41018371
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.40175369
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.33675738
11AR_21572438_ChIP-Seq_LNCaP_Human2.24429347
12EWS_26573619_Chip-Seq_HEK293_Human2.23591450
13VDR_22108803_ChIP-Seq_LS180_Human2.16534765
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.13752361
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12548327
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09914051
17FUS_26573619_Chip-Seq_HEK293_Human2.08172914
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07571148
19PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04109355
20SMAD3_21741376_ChIP-Seq_HESCs_Human2.03379009
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02798050
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02798050
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01151606
24POU5F1_16153702_ChIP-ChIP_HESCs_Human2.00833144
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99453545
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.98464778
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.90818201
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89136719
29TAF15_26573619_Chip-Seq_HEK293_Human1.88206277
30* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85865620
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.85479724
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83885846
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82604464
34ELK1_19687146_ChIP-ChIP_HELA_Human1.79053338
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77018579
36DROSHA_22980978_ChIP-Seq_HELA_Human1.75158151
37NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.74780378
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.74364943
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74356846
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72285105
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71682641
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70434310
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69127208
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68471830
45* SMAD4_21741376_ChIP-Seq_HESCs_Human1.68243694
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65929155
47* BCAT_22108803_ChIP-Seq_LS180_Human1.65104821
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.62575859
49IGF1R_20145208_ChIP-Seq_DFB_Human1.60527050
50* EZH2_27294783_Chip-Seq_ESCs_Mouse1.60493076
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.59772725
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.58888194
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57381141
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54797297
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52850598
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49571483
57NANOG_16153702_ChIP-ChIP_HESCs_Human1.47719579
58* SMAD4_21741376_ChIP-Seq_EPCs_Human1.47709208
59AR_21909140_ChIP-Seq_LNCAP_Human1.47541345
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46849105
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45575110
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45575110
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45575110
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44867050
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.43516449
66* SMAD3_21741376_ChIP-Seq_EPCs_Human1.43468400
67ER_23166858_ChIP-Seq_MCF-7_Human1.42997396
68* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42120597
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.40251023
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.40232324
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.40019583
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37568060
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37478489
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36573882
75AR_25329375_ChIP-Seq_VCAP_Human1.36366396
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35357657
77* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.35094780
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34447838
79* TCF4_22108803_ChIP-Seq_LS180_Human1.33955102
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33673183
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.33226312
82NANOG_19829295_ChIP-Seq_ESCs_Human1.31387807
83SOX2_19829295_ChIP-Seq_ESCs_Human1.31387807
84* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28455067
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28185121
86* CDX2_22108803_ChIP-Seq_LS180_Human1.27702859
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.26933836
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26849368
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.26620093
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.25350135
91AHR_22903824_ChIP-Seq_MCF-7_Human1.24146347
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23977893
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23801759
94CBP_20019798_ChIP-Seq_JUKART_Human1.23801759
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.23106928
96* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22207462
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.20592234
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20487132
99EZH2_22144423_ChIP-Seq_EOC_Human1.19990733
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19688123
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19421918
102ESR2_21235772_ChIP-Seq_MCF-7_Human1.18933362
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18201399
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18201399
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17743995
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16946288
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16608951
108* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16445423
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15857030
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15424830
111HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14594325
112TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14570878
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14495332
114RUNX2_22187159_ChIP-Seq_PCA_Human1.14419324
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13924117
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13447713
117ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12791365
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12778419
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10221867
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.10185276
121* STAT3_23295773_ChIP-Seq_U87_Human1.09164404
122* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08558181
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08153243
124TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07845344
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06993651
126OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06945294
127P300_18555785_Chip-Seq_ESCs_Mouse1.06450986
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06265871
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06245986
130* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05864807
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05580826
132P53_22387025_ChIP-Seq_ESCs_Mouse1.04595596
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04594982
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03937129
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03910839
136GATA1_19941826_ChIP-Seq_K562_Human1.03131692
137CBX2_27304074_Chip-Seq_ESCs_Mouse1.01427782
138TP53_16413492_ChIP-PET_HCT116_Human1.00347917
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.97913992
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95677304
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.94915679
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.94233840
143CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94098484
144TBL1_22424771_ChIP-Seq_293T_Human0.93809329
145SOX2_21211035_ChIP-Seq_LN229_Gbm0.92806744
146* P300_19829295_ChIP-Seq_ESCs_Human0.92255440
147* TCF4_23295773_ChIP-Seq_U87_Human0.92061609
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.91596713
149SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90406467
150VDR_24787735_ChIP-Seq_THP-1_Human0.89314119
151NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89109782
152SMAD4_21799915_ChIP-Seq_A2780_Human0.87444459
153* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87437433
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.87309392
155* RUNX_20019798_ChIP-Seq_JUKART_Human0.86984932
156EOMES_21245162_ChIP-Seq_HESCs_Human0.86445978
157PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86373172
158TP53_18474530_ChIP-ChIP_U2OS_Human0.85181765
159* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85137284
160EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83717816
161* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82640375
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81374524
163BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81256086
164* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80478163
165TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80094010
166PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78848244
167ISL1_27105846_Chip-Seq_CPCs_Mouse0.78768007
168NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78015755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.89111002
2MP0003890_abnormal_embryonic-extraembry5.58327943
3MP0002254_reproductive_system_inflammat5.46817033
4MP0004270_analgesia3.48469405
5MP0003690_abnormal_glial_cell3.45158912
6MP0004885_abnormal_endolymph3.45017327
7MP0008004_abnormal_stomach_pH2.96650312
8MP0003880_abnormal_central_pattern2.94963766
9MP0003950_abnormal_plasma_membrane2.91685180
10MP0003119_abnormal_digestive_system2.64687214
11MP0003634_abnormal_glial_cell2.63899345
12MP0003329_amyloid_beta_deposits2.59693515
13MP0005367_renal/urinary_system_phenotyp2.51377191
14MP0000516_abnormal_urinary_system2.51377191
15MP0010678_abnormal_skin_adnexa2.46451752
16MP0000462_abnormal_digestive_system2.41238386
17MP0000372_irregular_coat_pigmentation2.37462349
18MP0001984_abnormal_olfaction2.37419433
19MP0002736_abnormal_nociception_after2.36110991
20MP0004742_abnormal_vestibular_system2.33527212
21MP0006292_abnormal_olfactory_placode2.30828592
22MP0000383_abnormal_hair_follicle2.25482032
23MP0004134_abnormal_chest_morphology2.24097844
24MP0004859_abnormal_synaptic_plasticity2.23703399
25MP0002102_abnormal_ear_morphology2.16927030
26MP0005499_abnormal_olfactory_system2.16564382
27MP0005394_taste/olfaction_phenotype2.16564382
28MP0002272_abnormal_nervous_system2.16364269
29MP0004264_abnormal_extraembryonic_tissu2.12185461
30MP0001486_abnormal_startle_reflex2.08336602
31MP0000778_abnormal_nervous_system2.06541234
32MP0008877_abnormal_DNA_methylation2.05794217
33MP0002938_white_spotting2.02452540
34MP0002064_seizures2.02246449
35MP0003632_abnormal_nervous_system2.02103929
36MP0001485_abnormal_pinna_reflex1.96142844
37MP0001293_anophthalmia1.96120760
38MP0005171_absent_coat_pigmentation1.87452882
39MP0001905_abnormal_dopamine_level1.83652741
40MP0002229_neurodegeneration1.79348034
41MP0005409_darkened_coat_color1.76882263
42MP0004142_abnormal_muscle_tone1.71941291
43MP0004133_heterotaxia1.70671962
44MP0001661_extended_life_span1.70477311
45MP0001299_abnormal_eye_distance/1.70062098
46MP0001346_abnormal_lacrimal_gland1.67987130
47MP0003941_abnormal_skin_development1.64481370
48MP0005623_abnormal_meninges_morphology1.64333770
49MP0005451_abnormal_body_composition1.63151748
50MP0003567_abnormal_fetal_cardiomyocyte1.57336122
51MP0008057_abnormal_DNA_replication1.55277552
52MP0000955_abnormal_spinal_cord1.54231787
53MP0002233_abnormal_nose_morphology1.54221818
54MP0010094_abnormal_chromosome_stability1.51241781
55MP0000604_amyloidosis1.49517133
56MP0003635_abnormal_synaptic_transmissio1.48499300
57MP0001286_abnormal_eye_development1.46753945
58MP0004957_abnormal_blastocyst_morpholog1.46492155
59MP0008995_early_reproductive_senescence1.44662394
60MP0002933_joint_inflammation1.43886741
61MP0002734_abnormal_mechanical_nocicepti1.42805590
62MP0003136_yellow_coat_color1.42726690
63MP0000762_abnormal_tongue_morphology1.42072949
64MP0009745_abnormal_behavioral_response1.40607349
65MP0001529_abnormal_vocalization1.39622453
66MP0009780_abnormal_chondrocyte_physiolo1.36889951
67MP0003693_abnormal_embryo_hatching1.35293619
68MP0009384_cardiac_valve_regurgitation1.33684309
69MP0003631_nervous_system_phenotype1.33337492
70MP0003718_maternal_effect1.32916928
71MP0009046_muscle_twitch1.32022120
72MP0008058_abnormal_DNA_repair1.29165209
73MP0000427_abnormal_hair_cycle1.26812601
74MP0004272_abnormal_basement_membrane1.26611743
75MP0002882_abnormal_neuron_morphology1.25707146
76MP0000747_muscle_weakness1.25134798
77MP0001666_abnormal_nutrient_absorption1.22366609
78MP0003121_genomic_imprinting1.21744190
79MP0002084_abnormal_developmental_patter1.19665939
80MP0004147_increased_porphyrin_level1.18152031
81MP0005075_abnormal_melanosome_morpholog1.17909548
82MP0001963_abnormal_hearing_physiology1.17126386
83MP0000647_abnormal_sebaceous_gland1.16062829
84MP0001851_eye_inflammation1.15903493
85MP0005551_abnormal_eye_electrophysiolog1.14813307
86MP0004185_abnormal_adipocyte_glucose1.14807209
87MP0008569_lethality_at_weaning1.14458518
88MP0003943_abnormal_hepatobiliary_system1.12932312
89MP0002066_abnormal_motor_capabilities/c1.12078370
90MP0003787_abnormal_imprinting1.11441804
91MP0010030_abnormal_orbit_morphology1.11414510
92MP0005187_abnormal_penis_morphology1.10182918
93MP0008438_abnormal_cutaneous_collagen1.09779357
94MP0002751_abnormal_autonomic_nervous1.09662072
95MP0002067_abnormal_sensory_capabilities1.09139880
96MP0003122_maternal_imprinting1.08925730
97MP0002111_abnormal_tail_morphology1.07721688
98MP0003633_abnormal_nervous_system1.04469372
99MP0002277_abnormal_respiratory_mucosa1.03797442
100MP0005410_abnormal_fertilization1.03355579
101MP0001672_abnormal_embryogenesis/_devel1.03038574
102MP0005380_embryogenesis_phenotype1.03038574
103MP0000467_abnormal_esophagus_morphology1.02782663
104MP0003937_abnormal_limbs/digits/tail_de1.00905168
105MP0008872_abnormal_physiological_respon1.00543171
106MP0003137_abnormal_impulse_conducting1.00278280
107MP0001177_atelectasis0.98212718
108MP0003385_abnormal_body_wall0.97656521
109MP0010234_abnormal_vibrissa_follicle0.97269293
110MP0004924_abnormal_behavior0.96733972
111MP0005386_behavior/neurological_phenoty0.96733972
112MP0002752_abnormal_somatic_nervous0.96000190
113MP0002572_abnormal_emotion/affect_behav0.94393705
114MP0003656_abnormal_erythrocyte_physiolo0.94032525
115MP0005174_abnormal_tail_pigmentation0.93987650
116MP0002138_abnormal_hepatobiliary_system0.93355040
117MP0002163_abnormal_gland_morphology0.92560506
118MP0002090_abnormal_vision0.91708023
119MP0001440_abnormal_grooming_behavior0.90572958
120MP0002085_abnormal_embryonic_tissue0.90418158
121MP0006054_spinal_hemorrhage0.90138859
122MP0003786_premature_aging0.90012090
123MP0003936_abnormal_reproductive_system0.88928067
124MP0000566_synostosis0.88767712
125MP0003806_abnormal_nucleotide_metabolis0.87996113
126MP0002063_abnormal_learning/memory/cond0.87808342
127MP0004381_abnormal_hair_follicle0.87321518
128MP0009703_decreased_birth_body0.85171385
129MP0002088_abnormal_embryonic_growth/wei0.85144452
130MP0003195_calcinosis0.84853810
131MP0004043_abnormal_pH_regulation0.83612131
132MP0001340_abnormal_eyelid_morphology0.83611525
133MP0005195_abnormal_posterior_eye0.82806781
134MP0003984_embryonic_growth_retardation0.82760152
135MP0008932_abnormal_embryonic_tissue0.82747252
136MP0005253_abnormal_eye_physiology0.82205738
137MP0002152_abnormal_brain_morphology0.82159322
138MP0003755_abnormal_palate_morphology0.82152737
139MP0003283_abnormal_digestive_organ0.81916890
140MP0003935_abnormal_craniofacial_develop0.81819151
141MP0005408_hypopigmentation0.81624772
142MP0000579_abnormal_nail_morphology0.80443501
143MP0009250_abnormal_appendicular_skeleto0.79878264
144MP0002108_abnormal_muscle_morphology0.77258156
145MP0005248_abnormal_Harderian_gland0.76461825
146MP0000428_abnormal_craniofacial_morphol0.76415493
147MP0005220_abnormal_exocrine_pancreas0.74863251
148MP0008260_abnormal_autophagy0.74380175
149MP0002295_abnormal_pulmonary_circulatio0.74343308
150MP0005423_abnormal_somatic_nervous0.73758675
151MP0000003_abnormal_adipose_tissue0.73730531
152MP0001697_abnormal_embryo_size0.73445508
153MP0004215_abnormal_myocardial_fiber0.73279069
154MP0001970_abnormal_pain_threshold0.73198985
155MP0000537_abnormal_urethra_morphology0.72268560
156MP0002733_abnormal_thermal_nociception0.72142374
157MP0000733_abnormal_muscle_development0.71571591
158MP0005395_other_phenotype0.71169409
159MP0000639_abnormal_adrenal_gland0.70901557
160MP0008789_abnormal_olfactory_epithelium0.69983403
161MP0005084_abnormal_gallbladder_morpholo0.69914684
162MP0000377_abnormal_hair_follicle0.69689907
163MP0002133_abnormal_respiratory_system0.69584833
164MP0005388_respiratory_system_phenotype0.69584833
165MP0001119_abnormal_female_reproductive0.69510453
166MP0000026_abnormal_inner_ear0.69361264
167MP0001968_abnormal_touch/_nociception0.68798655
168MP0000432_abnormal_head_morphology0.68017946
169MP0001324_abnormal_eye_pigmentation0.67411652
170MP0004484_altered_response_of0.67117405
171MP0000653_abnormal_sex_gland0.66615403
172MP0001929_abnormal_gametogenesis0.66205788
173MP0001943_abnormal_respiration0.66143733
174MP0002282_abnormal_trachea_morphology0.65815028
175MP0005391_vision/eye_phenotype0.63611052
176MP0004036_abnormal_muscle_relaxation0.63207030
177MP0006072_abnormal_retinal_apoptosis0.63019234
178MP0005381_digestive/alimentary_phenotyp0.62842116
179MP0000631_abnormal_neuroendocrine_gland0.60607513
180MP0002234_abnormal_pharynx_morphology0.59583264
181MP0002109_abnormal_limb_morphology0.58538351
182MP0000613_abnormal_salivary_gland0.58094396
183MP0001145_abnormal_male_reproductive0.57289827

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.84913464
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.84913464
3Neurofibrillary tangles (HP:0002185)5.38409404
4Small epiphyses (HP:0010585)5.31308709
5Sensory axonal neuropathy (HP:0003390)4.81802159
6Abnormality of the corticospinal tract (HP:0002492)4.38920994
7Septo-optic dysplasia (HP:0100842)4.30853528
8Epiphyseal dysplasia (HP:0002656)4.30129114
9Peripheral hypomyelination (HP:0007182)4.07959378
10Cerebral inclusion bodies (HP:0100314)3.93478845
11Insidious onset (HP:0003587)3.83241297
12Termporal pattern (HP:0011008)3.83241297
13Onion bulb formation (HP:0003383)3.82041563
14Intestinal atresia (HP:0011100)3.79016300
15Parakeratosis (HP:0001036)3.74868049
16Supranuclear gaze palsy (HP:0000605)3.43668448
17Congenital malformation of the right heart (HP:0011723)3.34295712
18Double outlet right ventricle (HP:0001719)3.34295712
19Anal stenosis (HP:0002025)3.31910978
20Akinesia (HP:0002304)3.29472110
21Intention tremor (HP:0002080)3.26438375
22Spastic gait (HP:0002064)3.25742038
23Abnormality of the fetal cardiovascular system (HP:0010948)3.18238698
24Abnormal umbilical cord blood vessels (HP:0011403)3.18238698
25Single umbilical artery (HP:0001195)3.18238698
26Volvulus (HP:0002580)3.16353794
27Alacrima (HP:0000522)3.15313702
28Abnormality of the parathyroid morphology (HP:0011766)3.15034762
29Abnormal pancreas size (HP:0012094)3.12223201
30Barrel-shaped chest (HP:0001552)3.10082259
31Absent radius (HP:0003974)3.06616126
32Irregular epiphyses (HP:0010582)3.02995656
33Oligodactyly (hands) (HP:0001180)2.95083221
34Aqueductal stenosis (HP:0002410)2.94217860
35Thickened helices (HP:0000391)2.91188714
36Anophthalmia (HP:0000528)2.91188224
37Abnormality of the phalanges of the 2nd finger (HP:0009541)2.88565912
38Abnormal auditory evoked potentials (HP:0006958)2.86909201
39Ependymoma (HP:0002888)2.86884246
40Absent forearm bone (HP:0003953)2.85679384
41Aplasia involving forearm bones (HP:0009822)2.85679384
42Abnormal lung lobation (HP:0002101)2.85636051
43Premature skin wrinkling (HP:0100678)2.83429040
44Bifid tongue (HP:0010297)2.82871867
45Hypoplastic ischia (HP:0003175)2.72294261
46Hypoplastic pelvis (HP:0008839)2.67298024
47Ulnar bowing (HP:0003031)2.65064614
48Anteriorly placed anus (HP:0001545)2.63434909
49Abnormal tarsal ossification (HP:0008369)2.60427161
50Hypoalphalipoproteinemia (HP:0003233)2.60345472
51Absent epiphyses (HP:0010577)2.58836684
52Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.58836684
53Dysmetria (HP:0001310)2.58073992
54Vertebral clefting (HP:0008428)2.57306741
55Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.54455133
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.54346972
57Decreased lacrimation (HP:0000633)2.52654564
58Abnormality of the labia minora (HP:0012880)2.50091214
59Labial hypoplasia (HP:0000066)2.47318718
60Abnormality of abdominal situs (HP:0011620)2.46920913
61Abdominal situs inversus (HP:0003363)2.46920913
62Renal hypoplasia (HP:0000089)2.46918352
63Delayed epiphyseal ossification (HP:0002663)2.43581254
64Abnormality of the ischium (HP:0003174)2.43380064
65Progressive inability to walk (HP:0002505)2.43045770
66Megalencephaly (HP:0001355)2.41282182
67Slow saccadic eye movements (HP:0000514)2.39745950
68Spastic paraparesis (HP:0002313)2.39371073
69Colon cancer (HP:0003003)2.39355110
70Coronal craniosynostosis (HP:0004440)2.38103669
71Relative macrocephaly (HP:0004482)2.35977498
72Autoamputation (HP:0001218)2.35335002
73Action tremor (HP:0002345)2.35242976
74Gonadotropin excess (HP:0000837)2.33874287
75Erythroderma (HP:0001019)2.30770595
76Cerebral hypomyelination (HP:0006808)2.30063470
77Flattened epiphyses (HP:0003071)2.29036522
78Optic nerve hypoplasia (HP:0000609)2.28537250
79Hypoplastic female external genitalia (HP:0012815)2.28404075
80Ankle clonus (HP:0011448)2.28261112
81Methylmalonic acidemia (HP:0002912)2.27703415
82Aplasia involving bones of the extremities (HP:0009825)2.26610549
83Aplasia involving bones of the upper limbs (HP:0009823)2.26610549
84Aplasia of the phalanges of the hand (HP:0009802)2.26610549
85Neoplasm of the adrenal gland (HP:0100631)2.26042984
86Segmental peripheral demyelination/remyelination (HP:0003481)2.26041060
87Gonadal dysgenesis (HP:0000133)2.25274226
88Abolished electroretinogram (ERG) (HP:0000550)2.23405363
89Stridor (HP:0010307)2.21753769
90Absent eyebrow (HP:0002223)2.21464061
91Irregular vertebral endplates (HP:0003301)2.20721600
92Neoplasm of the adrenal cortex (HP:0100641)2.20673291
93Infantile muscular hypotonia (HP:0008947)2.20477043
94Preaxial foot polydactyly (HP:0001841)2.19441856
95Genital tract atresia (HP:0001827)2.19362331
96Hyperglycinemia (HP:0002154)2.19035834
97Rectal fistula (HP:0100590)2.18451162
98Rectovaginal fistula (HP:0000143)2.18451162
99Vaginal atresia (HP:0000148)2.18388934
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16587405
101Astrocytoma (HP:0009592)2.16291515
102Abnormality of the astrocytes (HP:0100707)2.16291515
103Scanning speech (HP:0002168)2.15997942
104Aplasia/hypoplasia of the humerus (HP:0006507)2.14965998
105Hyperglycinuria (HP:0003108)2.14194292
106Abnormality of the vertebral endplates (HP:0005106)2.13791899
107Hypoplasia of the iris (HP:0007676)2.13228285
108Short humerus (HP:0005792)2.10030765
109Disproportionate short-trunk short stature (HP:0003521)2.09422335
110Aplasia/Hypoplasia of the spleen (HP:0010451)2.08773325
111Pancreatic islet-cell hyperplasia (HP:0004510)2.08697284
112Pancreatic cysts (HP:0001737)2.07361300
113Hammertoe (HP:0001765)2.06127316
114Glioma (HP:0009733)2.06025520
115Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06003225
116Esophageal atresia (HP:0002032)2.03087002
117Abnormality of the vitreous humor (HP:0004327)2.02457154
118Absent septum pellucidum (HP:0001331)2.01769561
119Asplenia (HP:0001746)2.01660705
120Abnormality of the septum pellucidum (HP:0007375)2.01532174
121Abnormal foot bone ossification (HP:0010675)2.01507364
122Small hand (HP:0200055)2.01422064
123Facial diplegia (HP:0001349)2.00804356
124Enlarged epiphyses (HP:0010580)2.00688159
125Cerebral hemorrhage (HP:0001342)2.00648198
126Myokymia (HP:0002411)2.00364323
127Bowel incontinence (HP:0002607)1.99977981
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.99444962
129Gastrointestinal atresia (HP:0002589)1.99114782
130Arthropathy (HP:0003040)1.98489119
131Stenosis of the external auditory canal (HP:0000402)1.98054725
132Decreased motor nerve conduction velocity (HP:0003431)1.98025477
133Degeneration of anterior horn cells (HP:0002398)1.97650824
134Abnormality of the anterior horn cell (HP:0006802)1.97650824
135Protuberant abdomen (HP:0001538)1.97170533
136Limited elbow extension (HP:0001377)1.96765615
137Abnormality of the middle phalanges of the toes (HP:0010183)1.96742096
138Vitreoretinal degeneration (HP:0000655)1.95410097
139Abnormal hair whorl (HP:0010721)1.94438064
140Abnormality of the umbilical cord (HP:0010881)1.93627704
141Short hallux (HP:0010109)1.90887101
142Meckel diverticulum (HP:0002245)1.90642742
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90558402
144Abnormality of chromosome stability (HP:0003220)1.89180537
145Hypolipoproteinemia (HP:0010981)1.89056532
146Abnormality of the 2nd finger (HP:0004100)1.88714487
147Renal agenesis (HP:0000104)1.88607233
148Humeroradial synostosis (HP:0003041)1.88549559
149Synostosis involving the elbow (HP:0003938)1.88549559
150Short femoral neck (HP:0100864)1.88442459
151Abnormality of methionine metabolism (HP:0010901)1.87897645
152Bilateral microphthalmos (HP:0007633)1.87103672
153Abnormality of the ileum (HP:0001549)1.85934300
154Abnormality of the duodenum (HP:0002246)1.85439602
155Bell-shaped thorax (HP:0001591)1.85356796
156Abnormality of serine family amino acid metabolism (HP:0010894)1.85117717
157Abnormality of glycine metabolism (HP:0010895)1.85117717
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.84939188
159Mixed hearing impairment (HP:0000410)1.84594900
160Abnormality of carpal bone ossification (HP:0006257)1.84244694
161Foot dorsiflexor weakness (HP:0009027)1.83581642
162Lower limb muscle weakness (HP:0007340)1.82983501
163Congenital ichthyosiform erythroderma (HP:0007431)1.82157565
164Deep venous thrombosis (HP:0002625)1.82132634
165Aplasia/Hypoplasia of the hallux (HP:0008362)1.81380501
166Hypoplasia of the capital femoral epiphysis (HP:0003090)1.81078574
167Hypoplasia of the fovea (HP:0007750)1.80349285
168Aplasia/Hypoplasia of the fovea (HP:0008060)1.80349285
169Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.80171556
170Abnormal large intestine physiology (HP:0012700)1.79530642
171Clumsiness (HP:0002312)1.79418349
172Widely spaced teeth (HP:0000687)1.79361799
173B lymphocytopenia (HP:0010976)1.79318384
174Abnormality of B cell number (HP:0010975)1.79318384
175Paraparesis (HP:0002385)1.79039526
176Increased circulating renin level (HP:0000848)1.78708866
177Cupped ear (HP:0000378)1.78248495
178Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.78173273
179Steppage gait (HP:0003376)1.76847700
180True hermaphroditism (HP:0010459)1.76602303
181Anal atresia (HP:0002023)1.76236168
182Abnormality of incisor morphology (HP:0011063)1.74360354
183Rhabdomyosarcoma (HP:0002859)1.73687321
184Chin dimple (HP:0010751)1.73535442
185Abnormality of the nasal septum (HP:0000419)1.72650517
186Vaginal fistula (HP:0004320)1.72385690
187Dandy-Walker malformation (HP:0001305)1.72237647
188Partial agenesis of the corpus callosum (HP:0001338)1.71723146
189Hyporeflexia of lower limbs (HP:0002600)1.71565471
190Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.71472510
191Methylmalonic aciduria (HP:0012120)1.71324295
192Oligodactyly (HP:0012165)1.71052179
193Abnormal biliary tract physiology (HP:0012439)1.69986384
194Bile duct proliferation (HP:0001408)1.69986384
195Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.69933720
196Intestinal fistula (HP:0100819)1.68814369
197Abnormal connection of the cardiac segments (HP:0011545)1.68156152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.17495143
2TRIM284.97274672
3OXSR14.40668575
4ACVR1B4.39835152
5EPHB13.37332210
6WNK33.32666322
7FGFR23.11227183
8SIK32.99805610
9MKNK22.77607703
10FRK2.66998653
11CDK192.56545690
12MET2.55917207
13WNK12.53324459
14ICK2.51777583
15BCR2.46887788
16WNK42.33761664
17PKN12.29096922
18TNIK2.22004193
19EIF2AK32.20238819
20ERBB32.18208777
21PRPF4B2.17240843
22PRKD32.16536838
23PAK61.89434674
24MKNK11.85995617
25PLK21.84829503
26NEK61.83069483
27CSNK1A1L1.81637473
28NTRK11.73749372
29CSNK1G31.69923623
30PLK31.69080823
31MAP3K101.68626437
32LIMK11.67016070
33GRK11.62119404
34UHMK11.55507029
35PDK21.54870422
36EIF2AK11.54154338
37PBK1.50241797
38MAPK131.47081142
39CSNK1G11.46122062
40TGFBR11.46029062
41ROCK21.41043027
42TYRO31.39425983
43CSNK1G21.32253504
44ZAK1.29110041
45FER1.28223409
46PAK31.27402244
47BRSK21.24171326
48CLK11.23455318
49PLK41.20286282
50CAMK2B1.20117998
51NLK1.17802275
52FGR1.15809690
53AKT31.13604838
54TAF11.12537334
55MST41.10238558
56MAP4K21.09486198
57PNCK1.08480502
58WEE11.03287144
59EPHA41.02644304
60MAPKAPK51.01580459
61PKN21.01308224
62CAMK2D1.00172790
63SGK2230.98751283
64SGK4940.98751283
65DDR20.98290804
66MARK20.97235103
67STK38L0.96631683
68FLT30.95361929
69VRK20.95122311
70PRKD10.94615995
71TSSK60.94304463
72FGFR10.93708117
73PRKCQ0.93069566
74STK30.90981236
75CDK140.85792009
76PDGFRB0.85001740
77PINK10.84488389
78CDK50.84387088
79INSRR0.80840076
80BRD40.80760128
81MINK10.80561871
82FYN0.80484758
83ERBB40.80008629
84TGFBR20.79091694
85CAMK1G0.78890635
86SRPK10.78771332
87BUB10.75911364
88MAPK70.75062215
89KSR20.73296002
90CDK150.71254931
91PRKCH0.70634036
92EIF2AK20.70590552
93TTK0.69071373
94PDPK10.68542156
95CSNK1D0.67233202
96CAMK2G0.66144510
97TESK20.65438150
98NEK10.64983369
99CDK180.64479164
100PLK10.62534863
101TRPM70.62147418
102CDK11A0.62029612
103STK110.60761654
104MAP3K130.59730845
105MAP3K20.58615371
106MELK0.57401374
107VRK10.55883635
108RET0.55528025
109HIPK20.54279201
110PIK3CA0.53730074
111MAPK150.52955656
112ITK0.51954473
113CAMK2A0.50573292
114BMPR1B0.49541145
115BMX0.48572296
116CSK0.48317367
117IRAK20.47421730
118GSK3A0.47236284
119INSR0.46282856
120STK160.46040415
121DMPK0.44774883
122GRK60.44748249
123PHKG10.44666621
124PHKG20.44666621
125RPS6KA50.44119635
126LATS10.42147901
127ADRBK10.42068037
128TIE10.42011031
129PRKCE0.41733199
130CASK0.40861972
131ADRBK20.40800086
132ROCK10.40745193
133IRAK10.40328422
134YES10.40121371
135MAP3K40.37802871
136ATM0.36854980
137DYRK1A0.36403200
138PDK10.35714980
139FES0.35057572
140PRKG10.34761623
141CSF1R0.34402444
142DYRK1B0.33230023
143MARK10.33163078
144PTK2B0.32763648
145BRSK10.32415381
146NUAK10.31941088
147MAP3K70.31143909
148PRKCG0.30191072
149STK40.29766256
150PRKD20.29609960
151MAP2K20.29182437
152BMPR20.28030264
153CDK60.27475385
154MAPK100.26826540
155MAP2K10.26773742
156SRC0.26386266
157ABL10.25836157
158STK100.25754877
159IGF1R0.24942391
160ATR0.24549821
161PRKCI0.23502174
162LMTK20.23439362
163EGFR0.22220976
164PRKDC0.20169380
165MARK30.19034459
166CSNK1A10.18155515
167NEK20.18084831
168KSR10.17057659
169MAP3K120.16837688
170RPS6KB10.14519923

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.88359192
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.77528561
3Fatty acid elongation_Homo sapiens_hsa000623.47933804
4Propanoate metabolism_Homo sapiens_hsa006403.34944058
5Proteasome_Homo sapiens_hsa030502.82067249
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66800609
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45199275
8Ether lipid metabolism_Homo sapiens_hsa005652.39990536
9Axon guidance_Homo sapiens_hsa043602.26935082
10Sulfur metabolism_Homo sapiens_hsa009202.25644721
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23489670
12Basal transcription factors_Homo sapiens_hsa030222.12835649
13Nitrogen metabolism_Homo sapiens_hsa009102.12747357
14Caffeine metabolism_Homo sapiens_hsa002322.11499420
15Pyruvate metabolism_Homo sapiens_hsa006201.80546267
16Sphingolipid metabolism_Homo sapiens_hsa006001.79380259
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73939843
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71313361
19RNA degradation_Homo sapiens_hsa030181.71016793
20Fanconi anemia pathway_Homo sapiens_hsa034601.66776334
21Renal cell carcinoma_Homo sapiens_hsa052111.62588139
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53944120
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.49804285
24TGF-beta signaling pathway_Homo sapiens_hsa043501.49653922
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49149146
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46949277
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.45579721
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45148607
29Homologous recombination_Homo sapiens_hsa034401.39368283
30Mismatch repair_Homo sapiens_hsa034301.37597082
31Basal cell carcinoma_Homo sapiens_hsa052171.36761342
32ECM-receptor interaction_Homo sapiens_hsa045121.34838588
33Phototransduction_Homo sapiens_hsa047441.34417877
34Fatty acid degradation_Homo sapiens_hsa000711.29358320
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28850825
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28208585
37Butanoate metabolism_Homo sapiens_hsa006501.28067240
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27820514
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23946629
40Retinol metabolism_Homo sapiens_hsa008301.23479973
41Glutamatergic synapse_Homo sapiens_hsa047241.21453046
42Dorso-ventral axis formation_Homo sapiens_hsa043201.21030199
43Tryptophan metabolism_Homo sapiens_hsa003801.20810468
44Selenocompound metabolism_Homo sapiens_hsa004501.20693462
45ErbB signaling pathway_Homo sapiens_hsa040121.18963961
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16140929
47RNA transport_Homo sapiens_hsa030131.15229745
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13160180
49GABAergic synapse_Homo sapiens_hsa047271.12538524
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.12511584
51beta-Alanine metabolism_Homo sapiens_hsa004101.11868533
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11123718
53Histidine metabolism_Homo sapiens_hsa003401.10245760
54Fat digestion and absorption_Homo sapiens_hsa049751.07078778
55B cell receptor signaling pathway_Homo sapiens_hsa046621.05661354
56Tight junction_Homo sapiens_hsa045301.05502859
57Oocyte meiosis_Homo sapiens_hsa041141.04939008
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03407444
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00877516
60Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00264272
61Endocytosis_Homo sapiens_hsa041440.99398027
62Linoleic acid metabolism_Homo sapiens_hsa005910.97852209
63Vitamin digestion and absorption_Homo sapiens_hsa049770.97670653
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96567483
65Morphine addiction_Homo sapiens_hsa050320.96549424
66Cell cycle_Homo sapiens_hsa041100.96243822
67Long-term depression_Homo sapiens_hsa047300.95046710
68Protein export_Homo sapiens_hsa030600.94401085
69p53 signaling pathway_Homo sapiens_hsa041150.92726939
70Alcoholism_Homo sapiens_hsa050340.90446750
71Serotonergic synapse_Homo sapiens_hsa047260.89126567
72RNA polymerase_Homo sapiens_hsa030200.87815715
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87806451
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86631164
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.86448051
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84950828
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84779263
78Fatty acid metabolism_Homo sapiens_hsa012120.84352901
79Ras signaling pathway_Homo sapiens_hsa040140.81383869
80Protein digestion and absorption_Homo sapiens_hsa049740.80097828
81Ovarian steroidogenesis_Homo sapiens_hsa049130.79841971
82Salivary secretion_Homo sapiens_hsa049700.79200789
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76384387
84Systemic lupus erythematosus_Homo sapiens_hsa053220.73707699
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.73147673
86Vitamin B6 metabolism_Homo sapiens_hsa007500.72937969
87Hedgehog signaling pathway_Homo sapiens_hsa043400.72756575
88Choline metabolism in cancer_Homo sapiens_hsa052310.72295345
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.71582764
90ABC transporters_Homo sapiens_hsa020100.70087971
91Arginine and proline metabolism_Homo sapiens_hsa003300.69798503
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.69343221
93Cholinergic synapse_Homo sapiens_hsa047250.69255355
94Adherens junction_Homo sapiens_hsa045200.69207914
95Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68903965
96Focal adhesion_Homo sapiens_hsa045100.68530918
97Circadian entrainment_Homo sapiens_hsa047130.68253938
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67902110
99Cocaine addiction_Homo sapiens_hsa050300.67530342
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67044970
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65930313
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65408594
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65309749
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64767223
105Malaria_Homo sapiens_hsa051440.62745906
106Gastric acid secretion_Homo sapiens_hsa049710.62218815
107Vibrio cholerae infection_Homo sapiens_hsa051100.61856598
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61160910
109Dopaminergic synapse_Homo sapiens_hsa047280.59536220
110Lysine degradation_Homo sapiens_hsa003100.58932871
111mRNA surveillance pathway_Homo sapiens_hsa030150.58862007
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56149640
113Nucleotide excision repair_Homo sapiens_hsa034200.55308284
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54484896
115Fatty acid biosynthesis_Homo sapiens_hsa000610.54341012
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.54024912
117Pancreatic secretion_Homo sapiens_hsa049720.53386559
118Prostate cancer_Homo sapiens_hsa052150.52660171
119Non-homologous end-joining_Homo sapiens_hsa034500.52509333
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51412679
121Metabolic pathways_Homo sapiens_hsa011000.51366982
122T cell receptor signaling pathway_Homo sapiens_hsa046600.51015153
123Bile secretion_Homo sapiens_hsa049760.47870176
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47558916
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47094580
126Carbon metabolism_Homo sapiens_hsa012000.47052719
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47006679
128Olfactory transduction_Homo sapiens_hsa047400.46770521
129Renin secretion_Homo sapiens_hsa049240.46645045
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.46480935
131cAMP signaling pathway_Homo sapiens_hsa040240.45904365
132MAPK signaling pathway_Homo sapiens_hsa040100.45406973
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45102867
134One carbon pool by folate_Homo sapiens_hsa006700.44643395
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44524315
136Proteoglycans in cancer_Homo sapiens_hsa052050.43933695
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43499461
138Lysosome_Homo sapiens_hsa041420.42496172
139Collecting duct acid secretion_Homo sapiens_hsa049660.42033825
140Chemical carcinogenesis_Homo sapiens_hsa052040.41603690
141Melanogenesis_Homo sapiens_hsa049160.41386890
142Chemokine signaling pathway_Homo sapiens_hsa040620.41373133
143Oxytocin signaling pathway_Homo sapiens_hsa049210.40697664
144Gap junction_Homo sapiens_hsa045400.40564525
145Glioma_Homo sapiens_hsa052140.39951109
146Colorectal cancer_Homo sapiens_hsa052100.39116225
147Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38937956
148Glutathione metabolism_Homo sapiens_hsa004800.37795978
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37618056
150N-Glycan biosynthesis_Homo sapiens_hsa005100.37366230
151Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36758663
152Hippo signaling pathway_Homo sapiens_hsa043900.36660947
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35771852
154Maturity onset diabetes of the young_Homo sapiens_hsa049500.35278397
155Peroxisome_Homo sapiens_hsa041460.34501007
156Amphetamine addiction_Homo sapiens_hsa050310.33691194
157Glycerolipid metabolism_Homo sapiens_hsa005610.32362483
158Starch and sucrose metabolism_Homo sapiens_hsa005000.32271063
159Mineral absorption_Homo sapiens_hsa049780.32200269
160Wnt signaling pathway_Homo sapiens_hsa043100.31713399
161Purine metabolism_Homo sapiens_hsa002300.31588618
162Drug metabolism - other enzymes_Homo sapiens_hsa009830.31057861
163Calcium signaling pathway_Homo sapiens_hsa040200.27878596

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »