SERP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.50063408
2Golgi transport vesicle coating (GO:0048200)7.50063408
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.87305851
4protein retention in ER lumen (GO:0006621)5.28589121
5COPII vesicle coating (GO:0048208)5.11333483
6signal peptide processing (GO:0006465)4.86282943
7exocrine pancreas development (GO:0031017)4.61879750
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.51846620
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51846620
10* activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.37323201
11antigen processing and presentation of endogenous antigen (GO:0019883)4.28085364
12* positive regulation of nuclease activity (GO:0032075)4.25159350
13ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.13262022
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.09351036
15* endoplasmic reticulum unfolded protein response (GO:0030968)4.03317624
16* regulation of nuclease activity (GO:0032069)3.92012916
17* cellular response to unfolded protein (GO:0034620)3.89914437
18sequestering of metal ion (GO:0051238)3.88083853
19UDP-N-acetylglucosamine metabolic process (GO:0006047)3.83516288
20intestinal cholesterol absorption (GO:0030299)3.80484986
21regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.77277085
22* ER-nucleus signaling pathway (GO:0006984)3.72538663
23* cellular response to topologically incorrect protein (GO:0035967)3.70012700
24valine metabolic process (GO:0006573)3.53981310
25protein maturation by protein folding (GO:0022417)3.53523747
26cysteine metabolic process (GO:0006534)3.53016445
274-hydroxyproline metabolic process (GO:0019471)3.51723709
28* response to endoplasmic reticulum stress (GO:0034976)3.43510748
29protein N-linked glycosylation via asparagine (GO:0018279)3.41934684
30L-phenylalanine catabolic process (GO:0006559)3.39957902
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.39957902
32peptidyl-asparagine modification (GO:0018196)3.39882506
33vesicle coating (GO:0006901)3.36456268
34L-phenylalanine metabolic process (GO:0006558)3.31108110
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.31108110
36sulfur amino acid catabolic process (GO:0000098)3.24252292
37protein N-linked glycosylation (GO:0006487)3.15373359
38response to peptidoglycan (GO:0032494)3.12013589
39endocrine pancreas development (GO:0031018)3.10946773
40formation of translation preinitiation complex (GO:0001731)3.00011198
41* response to unfolded protein (GO:0006986)2.91862683
42proline biosynthetic process (GO:0006561)2.89455352
43regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.87044524
44protein carboxylation (GO:0018214)2.85440625
45peptidyl-glutamic acid carboxylation (GO:0017187)2.85440625
46intestinal absorption (GO:0050892)2.82142758
47complement activation, classical pathway (GO:0006958)2.81772782
48* response to topologically incorrect protein (GO:0035966)2.81641214
49aromatic amino acid family catabolic process (GO:0009074)2.79404769
50apoptotic cell clearance (GO:0043277)2.78736180
51chaperone mediated protein folding requiring cofactor (GO:0051085)2.78458971
52alpha-linolenic acid metabolic process (GO:0036109)2.78381175
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77639782
54peptidyl-arginine methylation (GO:0018216)2.70058034
55peptidyl-arginine N-methylation (GO:0035246)2.70058034
56pentose-phosphate shunt (GO:0006098)2.69900864
57Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63858047
58ER overload response (GO:0006983)2.62959496
59ER to Golgi vesicle-mediated transport (GO:0006888)2.62665458
60immunoglobulin mediated immune response (GO:0016064)2.61618929
61fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56172676
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56137635
63homocysteine metabolic process (GO:0050667)2.55817201
64deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.54645106
65L-alpha-amino acid transmembrane transport (GO:1902475)2.53676844
66complement activation, alternative pathway (GO:0006957)2.52324029
67protein autoprocessing (GO:0016540)2.52016025
68cellular modified amino acid catabolic process (GO:0042219)2.51969616
69triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.51905927
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.51737506
71tricarboxylic acid metabolic process (GO:0072350)2.51495074
72peptidyl-arginine omega-N-methylation (GO:0035247)2.50816969
73complement activation (GO:0006956)2.50610214
74JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49951746
75regulation of cholesterol homeostasis (GO:2000188)2.49667662
76folic acid-containing compound biosynthetic process (GO:0009396)2.48693497
77definitive hemopoiesis (GO:0060216)2.48400456
78neutrophil activation involved in immune response (GO:0002283)2.47899023
79GDP-mannose metabolic process (GO:0019673)2.47667982
80axonemal dynein complex assembly (GO:0070286)2.47594672
81transcytosis (GO:0045056)2.47262742
82succinate metabolic process (GO:0006105)2.46052030
83cell redox homeostasis (GO:0045454)2.45363482
84regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.44340758
85positive regulation of granulocyte differentiation (GO:0030854)2.44029538
86NADPH regeneration (GO:0006740)2.43974552
87low-density lipoprotein particle clearance (GO:0034383)2.43186369
88maternal placenta development (GO:0001893)2.41825020
89detection of bacterium (GO:0016045)2.41695530
90positive regulation of gamma-delta T cell activation (GO:0046645)2.41651705
91regulation of interferon-beta biosynthetic process (GO:0045357)2.41456198
92peptide hormone processing (GO:0016486)2.41336600
93Golgi organization (GO:0007030)2.40347177
94tryptophan metabolic process (GO:0006568)2.38934330
95mitochondrial calcium ion transport (GO:0006851)2.38840302
96dosage compensation (GO:0007549)2.38823901
97negative regulation of fibrinolysis (GO:0051918)2.38591349
98regulation of Golgi to plasma membrane protein transport (GO:0042996)2.38064230
99peptide catabolic process (GO:0043171)2.37680212
100lysine metabolic process (GO:0006553)2.37665666
101lysine catabolic process (GO:0006554)2.37665666
102embryonic process involved in female pregnancy (GO:0060136)2.37514418
103antigen processing and presentation via MHC class Ib (GO:0002475)2.35740684
104detection of other organism (GO:0098543)2.35351367
1052-deoxyribonucleotide biosynthetic process (GO:0009265)2.34948207
106deoxyribose phosphate biosynthetic process (GO:0046385)2.34948207
107pyrimidine nucleotide catabolic process (GO:0006244)2.34310229
108activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.33790508
1093-UTR-mediated mRNA stabilization (GO:0070935)2.32436296
110urea metabolic process (GO:0019627)2.31757778
111urea cycle (GO:0000050)2.31757778
112serine family amino acid biosynthetic process (GO:0009070)2.31537705
113regulation of protein activation cascade (GO:2000257)2.30345325
114regulation of B cell differentiation (GO:0045577)2.29502244
115negative regulation of myeloid cell apoptotic process (GO:0033033)2.29314980
116positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.29136953
117glyoxylate metabolic process (GO:0046487)2.27882238
118B cell mediated immunity (GO:0019724)2.27253580
119indole-containing compound catabolic process (GO:0042436)2.26765934
120indolalkylamine catabolic process (GO:0046218)2.26765934
121tryptophan catabolic process (GO:0006569)2.26765934
122mannose metabolic process (GO:0006013)2.26687807
123positive regulation of B cell differentiation (GO:0045579)2.26473719
124positive regulation of fatty acid biosynthetic process (GO:0045723)2.26428158
125respiratory burst (GO:0045730)2.25803698
126ribosome assembly (GO:0042255)2.25560536
127localization within membrane (GO:0051668)2.25327446
128plasma lipoprotein particle clearance (GO:0034381)2.24823751
129actin nucleation (GO:0045010)2.24730031
130high-density lipoprotein particle remodeling (GO:0034375)2.24437759
131disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.23980179
132killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.23980179
133amyloid precursor protein catabolic process (GO:0042987)2.23782453
134regulation of glucose import in response to insulin stimulus (GO:2001273)2.23754545
135negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.23612058
136regulation of gamma-delta T cell differentiation (GO:0045586)2.23187520
137positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.22028260
138mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.22028260
139pinocytosis (GO:0006907)2.19154605
140negative regulation of erythrocyte differentiation (GO:0045647)2.16249804
141epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14208277
142negative regulation of interleukin-17 production (GO:0032700)2.13547724
143cilium or flagellum-dependent cell motility (GO:0001539)2.07959183
144response to muramyl dipeptide (GO:0032495)2.07085475
145positive regulation of mitochondrial membrane permeability (GO:0035794)2.05995934
146negative regulation of protein localization to plasma membrane (GO:1903077)2.04757756
147deoxyribose phosphate catabolic process (GO:0046386)2.04429840
148glycolipid catabolic process (GO:0019377)2.04233977
149NIK/NF-kappaB signaling (GO:0038061)2.04174701
150B cell receptor signaling pathway (GO:0050853)2.03682663
151nucleoside diphosphate biosynthetic process (GO:0009133)2.02108420
152cellular response to antibiotic (GO:0071236)2.00846476
153mitochondrial fragmentation involved in apoptotic process (GO:0043653)1.99066520
154primary alcohol catabolic process (GO:0034310)1.99018737
155glycosphingolipid catabolic process (GO:0046479)1.96884530
156deoxyribonucleotide catabolic process (GO:0009264)1.96211845
157response to UV-B (GO:0010224)1.95329931
158regulation of gamma-delta T cell activation (GO:0046643)1.95041430
159antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)1.93700415
160negative regulation of release of cytochrome c from mitochondria (GO:0090201)1.93514193
161SRP-dependent cotranslational protein targeting to membrane (GO:0006614)1.93199906
162positive regulation of interleukin-2 production (GO:0032743)1.92920637
163regulation of B cell receptor signaling pathway (GO:0050855)1.92483988
164surfactant homeostasis (GO:0043129)1.92458918
165polyamine biosynthetic process (GO:0006596)1.92234049
166regulation of interleukin-17 production (GO:0032660)1.92140314
167programmed necrotic cell death (GO:0097300)1.91682094
168antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)1.91305923
169positive regulation of mitochondrial fission (GO:0090141)1.90740039
170nitrogen cycle metabolic process (GO:0071941)1.90405362
171response to host immune response (GO:0052572)1.89983024
172response to immune response of other organism involved in symbiotic interaction (GO:0052564)1.89983024
173negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)1.89929822
174regulation of defense response to virus by virus (GO:0050690)1.89839352
175nucleotide-sugar biosynthetic process (GO:0009226)1.89545964

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.77979697
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.52067357
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.92796481
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.50095639
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.34087271
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.80364757
7GATA1_22025678_ChIP-Seq_K562_Human2.78517871
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.74194514
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.50690837
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.45277540
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.41884398
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.29402262
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25902524
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20363008
15MYC_22102868_ChIP-Seq_BL_Human2.16305756
16CLOCK_20551151_ChIP-Seq_293T_Human2.15643117
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.12267954
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10447396
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09836562
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06198030
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99425256
22NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92356781
23ZNF263_19887448_ChIP-Seq_K562_Human1.91928438
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90915074
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.89868109
26IRF8_27001747_Chip-Seq_BMDM_Mouse1.88685379
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.88352348
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86458226
29E2F7_22180533_ChIP-Seq_HELA_Human1.85616037
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84247970
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83467662
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82259698
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81886915
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79353242
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76537145
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74861895
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74483829
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.70600194
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68740719
40* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67248846
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65969363
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65142540
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64646985
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61897222
45* VDR_23849224_ChIP-Seq_CD4+_Human1.59452791
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58301187
47VDR_21846776_ChIP-Seq_THP-1_Human1.56045758
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52679922
49MYB_26560356_Chip-Seq_TH2_Human1.52166096
50FOXP3_21729870_ChIP-Seq_TREG_Human1.52063675
51XRN2_22483619_ChIP-Seq_HELA_Human1.50654075
52SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50287634
53* GABP_19822575_ChIP-Seq_HepG2_Human1.50198850
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49969830
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48800242
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48735249
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47228580
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46609414
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45164269
60* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44993429
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43518929
62* SPI1_23547873_ChIP-Seq_NB4_Human1.42509004
63MYB_26560356_Chip-Seq_TH1_Human1.42296120
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41730711
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40891759
66* ETS1_20019798_ChIP-Seq_JURKAT_Human1.39908137
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39051147
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.38427535
69MAF_26560356_Chip-Seq_TH1_Human1.35681576
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35588885
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35280112
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35169089
73ELK1_19687146_ChIP-ChIP_HELA_Human1.34386794
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33907544
75VDR_24763502_ChIP-Seq_THP-1_Human1.33704121
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33443020
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32017090
78CIITA_25753668_ChIP-Seq_RAJI_Human1.31369620
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30156823
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27338110
81TFEB_21752829_ChIP-Seq_HELA_Human1.24969971
82UTX_26944678_Chip-Seq_JUKART_Human1.24492233
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24411783
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24224342
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23002245
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21181283
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.20054194
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19714674
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19587152
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19427171
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18108609
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17765190
93TTF2_22483619_ChIP-Seq_HELA_Human1.17640939
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16910952
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16178370
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.14921431
97NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14919332
98GATA4_25053715_ChIP-Seq_YYC3_Human1.14121037
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13764624
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13306409
101GATA6_25053715_ChIP-Seq_YYC3_Human1.12678726
102GATA3_27048872_Chip-Seq_THYMUS_Human1.10852011
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09212590
104* ELF5_23300383_ChIP-Seq_T47D_Human1.07832885
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.07770392
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07131248
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07067932
108MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07054966
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06965900
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05951771
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04986559
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03716601
113GABP_17652178_ChIP-ChIP_JURKAT_Human1.03086019
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02704113
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02399062
116TCF7_22412390_ChIP-Seq_EML_Mouse1.01965737
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01487768
118SCL_19346495_ChIP-Seq_HPC-7_Human1.01450110
119ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00109835
120* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99319738
121FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99149926
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98699226
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98573854
124PU_27001747_Chip-Seq_BMDM_Mouse0.97942225
125RUNX_20019798_ChIP-Seq_JUKART_Human0.95490282
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.94929157
127ATF3_27146783_Chip-Seq_COLON_Human0.94453038
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94089740
129CHD1_26751641_Chip-Seq_LNCaP_Human0.93950908
130HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92289044
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92090911
132NCOR1_26117541_ChIP-Seq_K562_Human0.90934610
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90777632
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90713545
135KDM5A_27292631_Chip-Seq_BREAST_Human0.89882577
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.88448233
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86658233
138DCP1A_22483619_ChIP-Seq_HELA_Human0.84272330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.80252263
2MP0005365_abnormal_bile_salt3.22722622
3MP0005360_urolithiasis2.73302724
4MP0003300_gastrointestinal_ulcer2.70432495
5MP0001666_abnormal_nutrient_absorption2.63860901
6MP0005220_abnormal_exocrine_pancreas2.58443632
7MP0004782_abnormal_surfactant_physiolog2.53081527
8MP0005083_abnormal_biliary_tract2.47795359
9MP0005085_abnormal_gallbladder_physiolo2.41743692
10MP0002009_preneoplasia2.37917791
11MP0003303_peritoneal_inflammation2.22550822
12MP0003195_calcinosis2.20755648
13MP0005451_abnormal_body_composition2.16569420
14MP0003252_abnormal_bile_duct2.06651709
15MP0002877_abnormal_melanocyte_morpholog2.06542730
16MP0001835_abnormal_antigen_presentation2.04252311
17MP0008260_abnormal_autophagy1.96568970
18MP0006054_spinal_hemorrhage1.92265272
19MP0010234_abnormal_vibrissa_follicle1.90957382
20MP0005058_abnormal_lysosome_morphology1.87521703
21MP0002693_abnormal_pancreas_physiology1.86014248
22MP0003436_decreased_susceptibility_to1.85115993
23MP0002138_abnormal_hepatobiliary_system1.84756536
24MP0004264_abnormal_extraembryonic_tissu1.75286076
25MP0001944_abnormal_pancreas_morphology1.75224861
26MP0003183_abnormal_peptide_metabolism1.72841623
27MP0009840_abnormal_foam_cell1.70898616
28MP0008875_abnormal_xenobiotic_pharmacok1.65166523
29MP0003868_abnormal_feces_composition1.64456171
30MP0003806_abnormal_nucleotide_metabolis1.63340147
31MP0003191_abnormal_cellular_cholesterol1.63331805
32MP0009643_abnormal_urine_homeostasis1.58213848
33MP0001790_abnormal_immune_system1.56863772
34MP0005387_immune_system_phenotype1.56863772
35MP0003221_abnormal_cardiomyocyte_apopto1.55660750
36MP0000685_abnormal_immune_system1.55621559
37MP0002796_impaired_skin_barrier1.54092652
38MP0002166_altered_tumor_susceptibility1.52936248
39MP0003705_abnormal_hypodermis_morpholog1.52718807
40MP0009278_abnormal_bone_marrow1.49893096
41MP0001800_abnormal_humoral_immune1.49073089
42MP0005397_hematopoietic_system_phenotyp1.48612256
43MP0001545_abnormal_hematopoietic_system1.48612256
44MP0000609_abnormal_liver_physiology1.48039403
45MP0010329_abnormal_lipoprotein_level1.46398954
46MP0002132_abnormal_respiratory_system1.44444186
47MP0008438_abnormal_cutaneous_collagen1.41203052
48MP0002722_abnormal_immune_system1.33473851
49MP0005501_abnormal_skin_physiology1.32386107
50MP0005000_abnormal_immune_tolerance1.31975416
51MP0001845_abnormal_inflammatory_respons1.31847469
52MP0002452_abnormal_antigen_presenting1.31290898
53MP0004957_abnormal_blastocyst_morpholog1.26315563
54MP0005332_abnormal_amino_acid1.26306083
55MP0002419_abnormal_innate_immunity1.26197888
56MP0001853_heart_inflammation1.26099838
57MP0004808_abnormal_hematopoietic_stem1.25054576
58MP0004947_skin_inflammation1.24967278
59MP0010352_gastrointestinal_tract_polyps1.24809173
60MP0002429_abnormal_blood_cell1.24754497
61MP0005025_abnormal_response_to1.21016803
62MP0001873_stomach_inflammation1.20811085
63MP0008007_abnormal_cellular_replicative1.20742193
64MP0002396_abnormal_hematopoietic_system1.19670813
65MP0002723_abnormal_immune_serum1.18957092
66MP0009785_altered_susceptibility_to1.18787096
67MP0008469_abnormal_protein_level1.18417145
68MP0010155_abnormal_intestine_physiology1.16235553
69MP0001533_abnormal_skeleton_physiology1.15925953
70MP0005319_abnormal_enzyme/_coenzyme1.13218999
71MP0002928_abnormal_bile_duct1.12703334
72MP0002118_abnormal_lipid_homeostasis1.09626353
73MP0005671_abnormal_response_to1.09000782
74MP0002420_abnormal_adaptive_immunity1.07956444
75MP0002019_abnormal_tumor_incidence1.07020828
76MP0005084_abnormal_gallbladder_morpholo1.06427238
77MP0003186_abnormal_redox_activity1.05944974
78MP0001819_abnormal_immune_cell1.05850406
79MP0001851_eye_inflammation1.04559883
80MP0005464_abnormal_platelet_physiology1.04447807
81MP0000703_abnormal_thymus_morphology1.03785215
82MP0003724_increased_susceptibility_to1.03346926
83* MP0002078_abnormal_glucose_homeostasis1.02076527
84MP0005636_abnormal_mineral_homeostasis1.02059245
85MP0000598_abnormal_liver_morphology1.01778642
86MP0000013_abnormal_adipose_tissue1.01148355
87MP0003453_abnormal_keratinocyte_physiol0.99664374
88MP0005310_abnormal_salivary_gland0.99305255
89MP0005408_hypopigmentation0.98614968
90MP0002933_joint_inflammation0.97870118
91MP0003566_abnormal_cell_adhesion0.96710551
92MP0001727_abnormal_embryo_implantation0.95700286
93MP0005076_abnormal_cell_differentiation0.95421466
94MP0001881_abnormal_mammary_gland0.94639257
95MP0005166_decreased_susceptibility_to0.94225403
96MP0004043_abnormal_pH_regulation0.94102059
97MP0003075_altered_response_to0.93254626
98MP0008004_abnormal_stomach_pH0.92943549
99MP0001216_abnormal_epidermal_layer0.92305781
100MP0002148_abnormal_hypersensitivity_rea0.92275964
101MP0002006_tumorigenesis0.91324150
102MP0002909_abnormal_adrenal_gland0.90899422
103MP0002136_abnormal_kidney_physiology0.90819199
104MP0001756_abnormal_urination0.90637246
105MP0003172_abnormal_lysosome_physiology0.90412581
106MP0000313_abnormal_cell_death0.88778539
107MP0005621_abnormal_cell_physiology0.87330859
108MP0000716_abnormal_immune_system0.87057365
109MP0001764_abnormal_homeostasis0.86650550
110MP0002405_respiratory_system_inflammati0.86562482
111MP0003448_altered_tumor_morphology0.85780719
112MP0003656_abnormal_erythrocyte_physiolo0.84842926
113MP0000689_abnormal_spleen_morphology0.84011774
114MP0009333_abnormal_splenocyte_physiolog0.83772780
115MP0002398_abnormal_bone_marrow0.83306813
116MP0000858_altered_metastatic_potential0.83298072
117MP0009764_decreased_sensitivity_to0.83246571
118MP0000350_abnormal_cell_proliferation0.82770213
119MP0008057_abnormal_DNA_replication0.82006710
120MP0005023_abnormal_wound_healing0.81986039
121MP0000477_abnormal_intestine_morphology0.81650731
122MP0000343_altered_response_to0.80816040
123MP0004019_abnormal_vitamin_homeostasis0.80566678
124MP0003866_abnormal_defecation0.80408767
125MP0001765_abnormal_ion_homeostasis0.80083994
126MP0006082_CNS_inflammation0.79693244
127MP0002896_abnormal_bone_mineralization0.79241963
128MP0000490_abnormal_crypts_of0.79184043
129MP0000358_abnormal_cell_content/0.79172751
130* MP0003795_abnormal_bone_structure0.79103616
131MP0000465_gastrointestinal_hemorrhage0.78656830
132MP0001730_embryonic_growth_arrest0.78434348
133MP0009763_increased_sensitivity_to0.78316267
134MP0009931_abnormal_skin_appearance0.78278157
135MP0005584_abnormal_enzyme/coenzyme_acti0.77707703
136MP0009384_cardiac_valve_regurgitation0.77350440
137MP0003959_abnormal_lean_body0.76923656
138MP0003763_abnormal_thymus_physiology0.76685615

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.12121143
2Abnormality of the intrinsic pathway (HP:0010989)4.09481396
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.85983606
4Abnormality of the common coagulation pathway (HP:0010990)3.57467916
5Hypoglycemic seizures (HP:0002173)3.55553864
6Vacuolated lymphocytes (HP:0001922)3.54911542
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.43266307
8Chronic bronchitis (HP:0004469)3.40489653
9Dysostosis multiplex (HP:0000943)3.34834382
10Urinary glycosaminoglycan excretion (HP:0003541)3.27529704
11Mucopolysacchariduria (HP:0008155)3.27529704
12Hyperinsulinemic hypoglycemia (HP:0000825)3.27055065
13Intrahepatic cholestasis (HP:0001406)3.11200172
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.07033039
15Xanthomatosis (HP:0000991)3.06638620
16Symptomatic seizures (HP:0011145)2.93986342
17Recurrent gram-negative bacterial infections (HP:0005420)2.93146678
18Abnormal respiratory epithelium morphology (HP:0012253)2.92829627
19Abnormal respiratory motile cilium morphology (HP:0005938)2.92829627
20Petechiae (HP:0000967)2.91231061
21Abnormality of polysaccharide metabolism (HP:0011012)2.90566184
22Abnormality of glycosaminoglycan metabolism (HP:0004371)2.90566184
23Abnormality of mucopolysaccharide metabolism (HP:0011020)2.90566184
24Ketoacidosis (HP:0001993)2.84305507
25Absent/shortened dynein arms (HP:0200106)2.84293822
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.84293822
27Recurrent sinusitis (HP:0011108)2.83542236
28Deep venous thrombosis (HP:0002625)2.82339336
29Eczematoid dermatitis (HP:0000976)2.79991650
30Late onset (HP:0003584)2.74970687
31Prolonged partial thromboplastin time (HP:0003645)2.74158050
32Fat malabsorption (HP:0002630)2.73971212
33Abnormal respiratory motile cilium physiology (HP:0012261)2.72950089
34Ketosis (HP:0001946)2.72597998
35Myocardial infarction (HP:0001658)2.69833753
36Bronchiectasis (HP:0002110)2.68512019
37Rhinitis (HP:0012384)2.67331270
38Hyperactive renin-angiotensin system (HP:0000841)2.65904650
39Chronic obstructive pulmonary disease (HP:0006510)2.65202628
40Obstructive lung disease (HP:0006536)2.65202628
41Abnormality of the pancreatic islet cells (HP:0006476)2.63300854
42Abnormality of endocrine pancreas physiology (HP:0012093)2.63300854
43Elevated erythrocyte sedimentation rate (HP:0003565)2.58268607
44Nasal polyposis (HP:0100582)2.54210393
45Complement deficiency (HP:0004431)2.52617021
46Bronchitis (HP:0012387)2.49227472
47Thoracolumbar scoliosis (HP:0002944)2.48160279
48Abnormality of macrophages (HP:0004311)2.46996153
49Cellulitis (HP:0100658)2.46930779
50Abnormal ciliary motility (HP:0012262)2.44938357
51Abnormality of the anterior horn cell (HP:0006802)2.43198774
52Degeneration of anterior horn cells (HP:0002398)2.43198774
53Generalized aminoaciduria (HP:0002909)2.43046876
54Colitis (HP:0002583)2.42269654
55Chronic diarrhea (HP:0002028)2.41807831
56Hepatosplenomegaly (HP:0001433)2.40618105
57Abnormality of purine metabolism (HP:0004352)2.39028632
58Hypobetalipoproteinemia (HP:0003563)2.39025444
59Recurrent bacterial skin infections (HP:0005406)2.37605699
60Interstitial pulmonary disease (HP:0006530)2.37516029
61Recurrent viral infections (HP:0004429)2.37142902
62Hyperglycemia (HP:0003074)2.36435219
63Conjugated hyperbilirubinemia (HP:0002908)2.34534006
64Abnormality of the nasal mucosa (HP:0000433)2.34266384
65Mediastinal lymphadenopathy (HP:0100721)2.30891483
66Recurrent bronchitis (HP:0002837)2.29865337
67Joint hemorrhage (HP:0005261)2.29032181
68Abnormality of the prostate (HP:0008775)2.28033675
69Agammaglobulinemia (HP:0004432)2.26545764
70Urticaria (HP:0001025)2.25709784
71Abnormality of T cell physiology (HP:0011840)2.25546038
72Gout (HP:0001997)2.24093299
73Thrombocytosis (HP:0001894)2.22970489
74Steatorrhea (HP:0002570)2.22325613
75Mitral stenosis (HP:0001718)2.20352199
76Purpura (HP:0000979)2.19706140
77Inflammation of the large intestine (HP:0002037)2.19537083
78Seborrheic dermatitis (HP:0001051)2.17699792
79Gastrointestinal inflammation (HP:0004386)2.17626132
80Increased IgE level (HP:0003212)2.16182590
81Abdominal distention (HP:0003270)2.15834031
82Abnormality of complement system (HP:0005339)2.14810729
83Recurrent abscess formation (HP:0002722)2.14258325
84Hypertensive crisis (HP:0100735)2.13388180
85IgM deficiency (HP:0002850)2.13055683
86Dyschromatopsia (HP:0007641)2.12178611
87Protuberant abdomen (HP:0001538)2.10580841
88Curly hair (HP:0002212)2.10195154
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.09540987
90Loss of speech (HP:0002371)2.09302253
91Hypergammaglobulinemia (HP:0010702)2.08672806
92Abnormal foot bone ossification (HP:0010675)2.07108382
93Insulin resistance (HP:0000855)2.07061942
94Autoimmune hemolytic anemia (HP:0001890)2.06011305
95Pancreatitis (HP:0001733)2.05904661
96Type I transferrin isoform profile (HP:0003642)2.05634224
97Abnormality of sulfur amino acid metabolism (HP:0004339)2.04783923
98Acute hepatic failure (HP:0006554)2.04280684
99Reduced antithrombin III activity (HP:0001976)2.03985151
100Microvesicular hepatic steatosis (HP:0001414)2.02905140
101Abnormal platelet function (HP:0011869)2.02804613
102Impaired platelet aggregation (HP:0003540)2.02804613
103Lower limb hyperreflexia (HP:0002395)2.02511167
104Exocrine pancreatic insufficiency (HP:0001738)2.01713696
105Tetraparesis (HP:0002273)1.99774240
106Hematochezia (HP:0002573)1.97204921
107Abnormality of glutamine family amino acid metabolism (HP:0010902)1.96478063
108Myositis (HP:0100614)1.96340298
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96166254
110Abnormality of nucleobase metabolism (HP:0010932)1.95240612
111Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94418054
112Dicarboxylic aciduria (HP:0003215)1.94418054
113Osteomyelitis (HP:0002754)1.94096891
114Epistaxis (HP:0000421)1.93930755
115Recurrent otitis media (HP:0000403)1.93542558
116Abnormality of glycolipid metabolism (HP:0010969)1.93398567
117Abnormality of liposaccharide metabolism (HP:0010968)1.93398567
118Abnormality of glycosphingolipid metabolism (HP:0004343)1.93398567
119Abnormal tarsal ossification (HP:0008369)1.93138076
120Systemic lupus erythematosus (HP:0002725)1.92296403
121Gastrointestinal stroma tumor (HP:0100723)1.91801398
122Beaking of vertebral bodies (HP:0004568)1.91771582
123Vasculitis (HP:0002633)1.91162393
124Abnormal enzyme/coenzyme activity (HP:0012379)1.88235001
125Polygenic inheritance (HP:0010982)1.87987326
126Chronic otitis media (HP:0000389)1.87301309
127Elevated alkaline phosphatase (HP:0003155)1.86539239
128Glomerulonephritis (HP:0000099)1.86482112
129Male infertility (HP:0003251)1.86408772
130Prolonged bleeding time (HP:0003010)1.85934077
131Insulin-resistant diabetes mellitus (HP:0000831)1.85572087
132Severe short stature (HP:0003510)1.85401305
133B lymphocytopenia (HP:0010976)1.84544854
134Abnormal protein glycosylation (HP:0012346)1.84449360
135Abnormal glycosylation (HP:0012345)1.84449360
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84449360
137Abnormal protein N-linked glycosylation (HP:0012347)1.84449360
138Increased cerebral lipofuscin (HP:0011813)1.84363233
139Fatigue (HP:0012378)1.84200351
140Prolonged neonatal jaundice (HP:0006579)1.83757840
141Verrucae (HP:0200043)1.82896527
142Papilloma (HP:0012740)1.82896527
143Thoracic kyphosis (HP:0002942)1.82876734
144Abnormality of alkaline phosphatase activity (HP:0004379)1.82221357
145Erythema (HP:0010783)1.81731262
146Hyperlipoproteinemia (HP:0010980)1.79774985
147Flat acetabular roof (HP:0003180)1.79607883
148Abnormal pancreas size (HP:0012094)1.79219312
149Hypolipoproteinemia (HP:0010981)1.78272748
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.76805252
151Meningitis (HP:0001287)1.76769083
152Periodontitis (HP:0000704)1.75090151
153Microretrognathia (HP:0000308)1.74382484
154Abnormality of the distal phalanges of the toes (HP:0010182)1.74043845
155Pancreatic islet-cell hyperplasia (HP:0004510)1.73628706
156Multiple enchondromatosis (HP:0005701)1.73618456
157Menorrhagia (HP:0000132)1.73492942
158Hepatocellular carcinoma (HP:0001402)1.73354252
159Epidermoid cyst (HP:0200040)1.73229323
160Abnormality of transition element cation homeostasis (HP:0011030)1.72298792
161Abnormality of fatty-acid metabolism (HP:0004359)1.71821012
162Abnormality of B cell number (HP:0010975)1.71534373
163Hyperammonemia (HP:0001987)1.71113115
164Gingival bleeding (HP:0000225)1.70928155
165Cervical subluxation (HP:0003308)1.70727345
166Upper motor neuron abnormality (HP:0002127)1.70521261
167Hemorrhage of the eye (HP:0011885)1.69550707
168Recurrent fungal infections (HP:0002841)1.69443161
169Reticulocytosis (HP:0001923)1.69335662
170Skin rash (HP:0000988)1.68933496
171Granulocytopenia (HP:0001913)1.68289106
172T lymphocytopenia (HP:0005403)1.67468205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.37962874
2TAOK33.24212661
3BCKDK2.96542285
4TRIB32.90547792
5FLT32.80831957
6FRK2.63681146
7INSRR2.42533540
8PASK2.18084152
9PKN22.17312528
10SCYL22.16361442
11MAP4K12.13835596
12IRAK32.09218042
13BMPR22.08895796
14SIK11.95934917
15PRPF4B1.85692373
16EIF2AK31.82877334
17MAP3K101.81878108
18TYK21.76367873
19RIPK41.75097982
20NME21.74758338
21SRPK11.73228001
22AKT31.70105139
23PTK61.64721829
24TBK11.63882121
25JAK31.51131576
26LRRK21.46035272
27NEK91.42894856
28IRAK41.41762554
29SMG11.41569283
30FGFR41.41553474
31ZAP701.41190398
32EEF2K1.38403621
33BTK1.38001843
34MST41.36782112
35CSF1R1.34606634
36BLK1.34404959
37SIK31.30926559
38HIPK21.29459170
39EPHA31.29456826
40MAP3K131.28396100
41BCR1.26951275
42MAPK151.26570618
43CDK191.25260614
44RPS6KA41.25144894
45JAK11.20513730
46PIK3CG1.18409953
47ERBB31.17947843
48STK101.17638663
49DYRK1B1.15773826
50CSK1.14544078
51MAP3K31.14499593
52MAP2K71.12358685
53LATS11.12172394
54ARAF1.11376464
55TEC1.10007297
56TGFBR21.05095282
57MAP3K141.03070032
58MAPKAPK30.98843377
59MAP3K20.98026661
60MAP3K60.97679685
61MAP2K30.96919464
62EPHB10.95179710
63TRIM280.95157778
64TESK10.94005949
65TESK20.92667781
66KIT0.91956236
67GRK60.90868095
68STK38L0.89886811
69KSR20.89644039
70BRSK20.89571816
71JAK20.89564139
72MAP2K20.83449803
73ITK0.83349248
74TAOK20.82264068
75CSNK1G30.80723179
76NUAK10.78837488
77MAP3K120.78333749
78MAP3K40.77717002
79SYK0.77555988
80RIPK10.76719903
81PDGFRA0.75923497
82BRD40.75598095
83FGFR30.75298311
84IRAK10.74807685
85IKBKE0.74640301
86BRAF0.73724012
87CDK80.73466414
88MAP3K50.71423370
89NLK0.70966802
90STK240.70290521
91LYN0.69495201
92EIF2AK10.69149716
93KDR0.69098948
94PIM20.68995495
95IKBKB0.68418966
96YES10.66813953
97MET0.65008659
98RAF10.63706987
99CSNK1A1L0.63696797
100CDK60.63379942
101MST1R0.62631534
102PIM10.62239716
103CHUK0.59675228
104MAPK110.59193636
105DYRK30.57987976
106CAMK1D0.57196374
107MAP3K80.54042656
108CDK90.52822779
109MAP3K10.52769202
110DAPK10.51285636
111LCK0.50788545
112STK30.50459615
113RPS6KB20.50236126
114TSSK60.49145715
115PTK20.49063561
116CDK70.47442242
117MARK30.43017909
118PAK20.40426782
119HCK0.39276063
120DAPK30.38900432
121CSNK1G20.38746040
122PBK0.38306395
123EIF2AK20.37531311
124PDGFRB0.37118644
125EGFR0.36197327
126GSK3A0.35650036
127MTOR0.32765902
128CAMKK20.32462685
129ABL10.32410274
130IGF1R0.30704915
131MAP3K110.30436739
132EPHA20.28833028
133PAK40.28607770
134CDK40.26335412
135STK40.25772543
136MATK0.25271671
137WNK40.24535324

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.69922385
2Protein export_Homo sapiens_hsa030604.14112110
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.18021928
4Asthma_Homo sapiens_hsa053102.54656886
5Sulfur metabolism_Homo sapiens_hsa009202.47424139
6Allograft rejection_Homo sapiens_hsa053302.27196162
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.26668900
8Selenocompound metabolism_Homo sapiens_hsa004502.18942116
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.15056160
10Autoimmune thyroid disease_Homo sapiens_hsa053202.13458017
11Caffeine metabolism_Homo sapiens_hsa002322.09370531
12Folate biosynthesis_Homo sapiens_hsa007902.02825221
13Graft-versus-host disease_Homo sapiens_hsa053321.97425145
14N-Glycan biosynthesis_Homo sapiens_hsa005101.88862825
15Tryptophan metabolism_Homo sapiens_hsa003801.85428357
16Fat digestion and absorption_Homo sapiens_hsa049751.72846922
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71318780
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69438492
19Proteasome_Homo sapiens_hsa030501.65647007
20Other glycan degradation_Homo sapiens_hsa005111.65038290
21Shigellosis_Homo sapiens_hsa051311.64039780
22Type I diabetes mellitus_Homo sapiens_hsa049401.63769676
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58493448
24Complement and coagulation cascades_Homo sapiens_hsa046101.58146985
25Fatty acid degradation_Homo sapiens_hsa000711.56277685
26Nitrogen metabolism_Homo sapiens_hsa009101.45089898
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41991114
28Staphylococcus aureus infection_Homo sapiens_hsa051501.41747629
29Lysosome_Homo sapiens_hsa041421.37672543
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.35192356
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31943824
32Antigen processing and presentation_Homo sapiens_hsa046121.31529568
33Histidine metabolism_Homo sapiens_hsa003401.29111948
34Spliceosome_Homo sapiens_hsa030401.27827359
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24382596
36B cell receptor signaling pathway_Homo sapiens_hsa046621.19624988
37Rheumatoid arthritis_Homo sapiens_hsa053231.16774980
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.16281035
39Starch and sucrose metabolism_Homo sapiens_hsa005001.14894719
40Legionellosis_Homo sapiens_hsa051341.13513377
41Steroid biosynthesis_Homo sapiens_hsa001001.12815142
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10647785
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10371064
44Base excision repair_Homo sapiens_hsa034101.09798418
45Epstein-Barr virus infection_Homo sapiens_hsa051691.09392201
46Viral myocarditis_Homo sapiens_hsa054161.08880878
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08567984
48Peroxisome_Homo sapiens_hsa041461.08416009
49Arginine biosynthesis_Homo sapiens_hsa002201.07700168
50DNA replication_Homo sapiens_hsa030301.05212894
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02008809
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00781258
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00270361
54Pancreatic cancer_Homo sapiens_hsa052120.99786744
55Leishmaniasis_Homo sapiens_hsa051400.99230772
56Sulfur relay system_Homo sapiens_hsa041220.98990337
57Primary immunodeficiency_Homo sapiens_hsa053400.96181994
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95894298
59Ribosome_Homo sapiens_hsa030100.93024131
60Salmonella infection_Homo sapiens_hsa051320.92874169
61ABC transporters_Homo sapiens_hsa020100.92450835
62Protein digestion and absorption_Homo sapiens_hsa049740.91497542
63Fructose and mannose metabolism_Homo sapiens_hsa000510.90408527
64Pancreatic secretion_Homo sapiens_hsa049720.90138479
65One carbon pool by folate_Homo sapiens_hsa006700.89872712
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.89783475
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89018671
68Renin-angiotensin system_Homo sapiens_hsa046140.88354392
69Insulin resistance_Homo sapiens_hsa049310.86634746
70Phagosome_Homo sapiens_hsa041450.85709701
71Propanoate metabolism_Homo sapiens_hsa006400.85070921
72beta-Alanine metabolism_Homo sapiens_hsa004100.83844112
73Galactose metabolism_Homo sapiens_hsa000520.81745011
74PPAR signaling pathway_Homo sapiens_hsa033200.80330371
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79481520
76Thyroid cancer_Homo sapiens_hsa052160.77224007
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.76951372
78Mismatch repair_Homo sapiens_hsa034300.75931116
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75267930
80Fatty acid metabolism_Homo sapiens_hsa012120.75136092
81mRNA surveillance pathway_Homo sapiens_hsa030150.74570173
82Chemical carcinogenesis_Homo sapiens_hsa052040.74170243
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71923606
84Osteoclast differentiation_Homo sapiens_hsa043800.69137387
85Pyrimidine metabolism_Homo sapiens_hsa002400.68871519
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68774772
87Phenylalanine metabolism_Homo sapiens_hsa003600.67345683
88Pentose phosphate pathway_Homo sapiens_hsa000300.66536346
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66143166
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64945094
91Lysine degradation_Homo sapiens_hsa003100.63835700
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63614937
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.62650739
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61875791
95RNA transport_Homo sapiens_hsa030130.61253924
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60891812
97Vitamin digestion and absorption_Homo sapiens_hsa049770.60684471
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60643175
99Viral carcinogenesis_Homo sapiens_hsa052030.59995481
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59341525
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58368427
102Pertussis_Homo sapiens_hsa051330.58145381
103Nucleotide excision repair_Homo sapiens_hsa034200.56158846
104RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55707640
105Butanoate metabolism_Homo sapiens_hsa006500.55084201
106Toxoplasmosis_Homo sapiens_hsa051450.54505367
107Sphingolipid metabolism_Homo sapiens_hsa006000.53760151
108Hematopoietic cell lineage_Homo sapiens_hsa046400.53759018
109Glycerolipid metabolism_Homo sapiens_hsa005610.53387886
110Arginine and proline metabolism_Homo sapiens_hsa003300.53381799
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.52578662
112Measles_Homo sapiens_hsa051620.50786834
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50783891
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.49204604
115Biosynthesis of amino acids_Homo sapiens_hsa012300.49014125
116Influenza A_Homo sapiens_hsa051640.48970424
117Systemic lupus erythematosus_Homo sapiens_hsa053220.48758857
118Prolactin signaling pathway_Homo sapiens_hsa049170.48346313
119Non-homologous end-joining_Homo sapiens_hsa034500.48174146
120T cell receptor signaling pathway_Homo sapiens_hsa046600.47074739
121Tuberculosis_Homo sapiens_hsa051520.46695497
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46139430
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46128851
124Hepatitis C_Homo sapiens_hsa051600.45731414
125Pyruvate metabolism_Homo sapiens_hsa006200.45538670
126Tyrosine metabolism_Homo sapiens_hsa003500.45195466
127Apoptosis_Homo sapiens_hsa042100.45117156
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44773921
129Non-small cell lung cancer_Homo sapiens_hsa052230.44704714
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43750576
131Acute myeloid leukemia_Homo sapiens_hsa052210.42994130
132Bladder cancer_Homo sapiens_hsa052190.42616832
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.42249539
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.42235017
135Hepatitis B_Homo sapiens_hsa051610.41829514
136Retinol metabolism_Homo sapiens_hsa008300.41780143
137Chronic myeloid leukemia_Homo sapiens_hsa052200.41690469
138Glutathione metabolism_Homo sapiens_hsa004800.41344761
139Vibrio cholerae infection_Homo sapiens_hsa051100.41251190
140Carbon metabolism_Homo sapiens_hsa012000.41244990
141Herpes simplex infection_Homo sapiens_hsa051680.39579660
142TNF signaling pathway_Homo sapiens_hsa046680.38996169
143Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38148633
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.36761042

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