SERP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.96763476
2synaptic vesicle exocytosis (GO:0016079)5.88471495
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84762246
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.43670942
5vocalization behavior (GO:0071625)5.42014696
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27431827
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.20802048
8locomotory exploration behavior (GO:0035641)5.19825803
9glutamate secretion (GO:0014047)5.17444847
10protein localization to synapse (GO:0035418)5.14151370
11pyrimidine nucleobase catabolic process (GO:0006208)5.02837006
12regulation of synapse structural plasticity (GO:0051823)4.98434520
13regulation of synaptic vesicle exocytosis (GO:2000300)4.96707243
14neuron cell-cell adhesion (GO:0007158)4.83945379
15regulation of glutamate receptor signaling pathway (GO:1900449)4.76258332
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.47693512
17exploration behavior (GO:0035640)4.46874291
18regulation of synaptic vesicle transport (GO:1902803)4.42097959
19neurotransmitter secretion (GO:0007269)4.38824664
20ionotropic glutamate receptor signaling pathway (GO:0035235)4.36975796
21neuronal action potential propagation (GO:0019227)4.36247098
22layer formation in cerebral cortex (GO:0021819)4.32238726
23nucleobase catabolic process (GO:0046113)4.21427824
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.15583919
25regulation of neuronal synaptic plasticity (GO:0048168)4.12695872
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.05079772
27presynaptic membrane organization (GO:0097090)4.04293254
28synaptic transmission, glutamatergic (GO:0035249)3.95813492
29glutamate receptor signaling pathway (GO:0007215)3.94542702
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.93897149
31neuron-neuron synaptic transmission (GO:0007270)3.91516273
32positive regulation of synaptic transmission, GABAergic (GO:0032230)3.82579743
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.80567685
34neurotransmitter-gated ion channel clustering (GO:0072578)3.76258585
35positive regulation of membrane potential (GO:0045838)3.71841785
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71443256
37positive regulation of synapse maturation (GO:0090129)3.71412475
38dendritic spine morphogenesis (GO:0060997)3.70858043
39neuron recognition (GO:0008038)3.69869331
40neuronal ion channel clustering (GO:0045161)3.58481171
41postsynaptic membrane organization (GO:0001941)3.56416392
42long-term memory (GO:0007616)3.56153252
43regulation of postsynaptic membrane potential (GO:0060078)3.54854961
44gamma-aminobutyric acid transport (GO:0015812)3.51231400
45proline transport (GO:0015824)3.50580021
46regulation of dendritic spine morphogenesis (GO:0061001)3.49413395
47negative regulation of microtubule polymerization (GO:0031115)3.48611428
48positive regulation of dendritic spine morphogenesis (GO:0061003)3.48419852
49neurotransmitter transport (GO:0006836)3.47679447
50C4-dicarboxylate transport (GO:0015740)3.45549906
51synaptic vesicle endocytosis (GO:0048488)3.43358798
52regulation of neurotransmitter secretion (GO:0046928)3.42566371
53membrane depolarization during action potential (GO:0086010)3.41713410
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41341519
55behavioral fear response (GO:0001662)3.38905943
56behavioral defense response (GO:0002209)3.38905943
57cell migration in hindbrain (GO:0021535)3.38791226
58activation of protein kinase A activity (GO:0034199)3.38010819
59regulation of synaptic plasticity (GO:0048167)3.36791883
60positive regulation of neurotransmitter transport (GO:0051590)3.35628743
61cellular potassium ion homeostasis (GO:0030007)3.33965734
62regulation of vesicle fusion (GO:0031338)3.32482506
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30555224
64positive regulation of synapse assembly (GO:0051965)3.29995578
65sodium ion export (GO:0071436)3.28942441
66positive regulation of dendritic spine development (GO:0060999)3.28037564
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.27120405
68regulation of neurotransmitter levels (GO:0001505)3.26583138
69axonal fasciculation (GO:0007413)3.26302214
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.24596877
71membrane hyperpolarization (GO:0060081)3.23666660
72long-term synaptic potentiation (GO:0060291)3.23466045
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.23244953
74behavioral response to cocaine (GO:0048148)3.19968109
75fear response (GO:0042596)3.17423448
76regulation of dendritic spine development (GO:0060998)3.17233714
77central nervous system myelination (GO:0022010)3.16851700
78axon ensheathment in central nervous system (GO:0032291)3.16851700
79regulation of neurotransmitter transport (GO:0051588)3.16779411
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16565602
81response to histamine (GO:0034776)3.16144378
82cerebellar Purkinje cell differentiation (GO:0021702)3.14514883
83transmission of nerve impulse (GO:0019226)3.13056035
84behavioral response to nicotine (GO:0035095)3.12788543
85establishment of mitochondrion localization (GO:0051654)3.12427904
86presynaptic membrane assembly (GO:0097105)3.11734904
87regulation of glutamate secretion (GO:0014048)3.11223783
88membrane depolarization (GO:0051899)3.10765380
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.10616258
90response to auditory stimulus (GO:0010996)3.08166462
91regulation of synapse maturation (GO:0090128)3.07794970
92intraspecies interaction between organisms (GO:0051703)3.07410249
93social behavior (GO:0035176)3.07410249
94response to pheromone (GO:0019236)3.07214736
95neuromuscular process controlling posture (GO:0050884)3.07029050
96learning (GO:0007612)3.06509713
97negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06401795
98auditory behavior (GO:0031223)3.06183890
99neuromuscular process controlling balance (GO:0050885)3.05651047
100dendrite morphogenesis (GO:0048813)3.05413358
101regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04831965
102cell communication by electrical coupling (GO:0010644)3.03803673
103synapse assembly (GO:0007416)3.03391848
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03298908
105dopamine receptor signaling pathway (GO:0007212)3.02427711
106dendritic spine organization (GO:0097061)3.02070996
107positive regulation of neurotransmitter secretion (GO:0001956)3.01695076
108acidic amino acid transport (GO:0015800)3.00897875
109establishment of synaptic vesicle localization (GO:0097480)3.00826556
110synaptic vesicle transport (GO:0048489)3.00826556
111vesicle transport along microtubule (GO:0047496)3.00719871
112positive regulation of synaptic transmission (GO:0050806)2.99829411
113prepulse inhibition (GO:0060134)2.99734041
114mechanosensory behavior (GO:0007638)2.98795500
115synaptic transmission, dopaminergic (GO:0001963)2.98513596
116synaptic transmission (GO:0007268)2.97424321
117negative regulation of dendrite development (GO:2000171)2.97362366
118regulation of female receptivity (GO:0045924)2.96607833
119cerebellar granule cell differentiation (GO:0021707)2.95579290
120adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.90343648
121neuromuscular synaptic transmission (GO:0007274)2.88829215
122adult walking behavior (GO:0007628)2.88635516
123regulation of voltage-gated calcium channel activity (GO:1901385)2.88567286
124L-amino acid import (GO:0043092)2.86960109
125calcium ion-dependent exocytosis (GO:0017156)2.83566896
126glycosphingolipid biosynthetic process (GO:0006688)2.82637883
127regulation of microtubule-based movement (GO:0060632)2.80158180
128synapse organization (GO:0050808)2.76761430
129central nervous system projection neuron axonogenesis (GO:0021952)2.75334806
130short-term memory (GO:0007614)2.74054691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.33114472
2GBX2_23144817_ChIP-Seq_PC3_Human3.46247087
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.33643976
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27680619
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.24913693
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.92220330
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.88403395
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.87667117
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.87667117
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.77853281
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.74546261
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.67904366
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65852774
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.65730805
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65622275
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.62961696
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54208691
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.50237502
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.47073853
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.43769077
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.42923153
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.35808113
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.29170846
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19255065
25DROSHA_22980978_ChIP-Seq_HELA_Human2.17198437
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.04400058
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96824108
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89172644
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88074834
30TAF15_26573619_Chip-Seq_HEK293_Human1.86055811
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85919325
32AR_21572438_ChIP-Seq_LNCaP_Human1.79623684
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.72148024
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69596578
35ZNF274_21170338_ChIP-Seq_K562_Hela1.61102366
36SMAD4_21799915_ChIP-Seq_A2780_Human1.51528658
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50679727
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49188921
39ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46156666
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42948319
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42865714
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41192553
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40677839
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.39707694
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37474624
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35907732
47* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35022822
48P300_19829295_ChIP-Seq_ESCs_Human1.34489842
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.31497193
50* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25823206
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.25802508
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25587788
53RNF2_27304074_Chip-Seq_NSC_Mouse1.25465878
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24284254
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22046485
56AR_25329375_ChIP-Seq_VCAP_Human1.20612839
57IGF1R_20145208_ChIP-Seq_DFB_Human1.17296053
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.16297973
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15821166
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15733823
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.15109153
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13772258
63AR_19668381_ChIP-Seq_PC3_Human1.08593613
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08451833
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08242963
66* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05359069
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04620699
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02776224
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02184653
70* STAT3_23295773_ChIP-Seq_U87_Human1.01650311
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01598697
72SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00006481
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99858695
74ARNT_22903824_ChIP-Seq_MCF-7_Human0.99138560
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99124682
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98993622
77KDM2B_26808549_Chip-Seq_K562_Human0.97908305
78JUN_21703547_ChIP-Seq_K562_Human0.97549281
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96732309
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96611843
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96477024
82AHR_22903824_ChIP-Seq_MCF-7_Human0.95491528
83VDR_22108803_ChIP-Seq_LS180_Human0.95118115
84GATA1_26923725_Chip-Seq_HPCs_Mouse0.93130408
85PRDM14_20953172_ChIP-Seq_ESCs_Human0.92555226
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.92373338
87* TCF4_23295773_ChIP-Seq_U87_Human0.91797951
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91300983
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91128106
90* RUNX2_22187159_ChIP-Seq_PCA_Human0.89937112
91TET1_21490601_ChIP-Seq_MESCs_Mouse0.89792555
92* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89649394
93* CBP_20019798_ChIP-Seq_JUKART_Human0.89649394
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.89556324
95* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89536521
96FUS_26573619_Chip-Seq_HEK293_Human0.88249213
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88232567
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88135155
99CTCF_27219007_Chip-Seq_Bcells_Human0.87537372
100POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86356861
101OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84961039
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84852924
103* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84719438
104TP53_20018659_ChIP-ChIP_R1E_Mouse0.84492925
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84440015
106* SMAD4_21741376_ChIP-Seq_HESCs_Human0.84301139
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84190787
108BCAT_22108803_ChIP-Seq_LS180_Human0.83868742
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82489312
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82199009
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81165740
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81165740
113SMAD_19615063_ChIP-ChIP_OVARY_Human0.81081956
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80784623

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.18772219
2MP0003880_abnormal_central_pattern4.85693582
3MP0003635_abnormal_synaptic_transmissio4.09082738
4MP0004270_analgesia3.74277648
5MP0002063_abnormal_learning/memory/cond3.37030926
6MP0009745_abnormal_behavioral_response3.35024214
7MP0001968_abnormal_touch/_nociception3.26350884
8MP0002064_seizures3.07125076
9MP0009046_muscle_twitch2.84462623
10MP0002572_abnormal_emotion/affect_behav2.83880111
11MP0002734_abnormal_mechanical_nocicepti2.73491867
12MP0002735_abnormal_chemical_nociception2.69406899
13MP0002822_catalepsy2.65421070
14MP0005423_abnormal_somatic_nervous2.64621584
15MP0002736_abnormal_nociception_after2.63255950
16MP0002272_abnormal_nervous_system2.52870788
17MP0001486_abnormal_startle_reflex2.41005912
18MP0006276_abnormal_autonomic_nervous2.40917876
19MP0002733_abnormal_thermal_nociception2.34595290
20MP0001440_abnormal_grooming_behavior2.27691813
21MP0001970_abnormal_pain_threshold2.20221061
22MP0001501_abnormal_sleep_pattern2.04381178
23MP0002184_abnormal_innervation2.03635676
24MP0004858_abnormal_nervous_system2.02304036
25MP0000778_abnormal_nervous_system2.00739847
26MP0002067_abnormal_sensory_capabilities1.95233853
27MP0003122_maternal_imprinting1.93741085
28MP0003879_abnormal_hair_cell1.92500897
29MP0001984_abnormal_olfaction1.91750025
30MP0001529_abnormal_vocalization1.88093023
31MP0002557_abnormal_social/conspecific_i1.85665645
32MP0004811_abnormal_neuron_physiology1.84896262
33MP0003329_amyloid_beta_deposits1.77950602
34MP0004924_abnormal_behavior1.74668634
35MP0005386_behavior/neurological_phenoty1.74668634
36MP0002909_abnormal_adrenal_gland1.74315297
37MP0009780_abnormal_chondrocyte_physiolo1.68959646
38MP0008569_lethality_at_weaning1.62450670
39MP0000955_abnormal_spinal_cord1.57645503
40MP0005645_abnormal_hypothalamus_physiol1.56247042
41MP0001905_abnormal_dopamine_level1.50665053
42MP0005646_abnormal_pituitary_gland1.45571725
43MP0002882_abnormal_neuron_morphology1.45276900
44MP0008877_abnormal_DNA_methylation1.45274814
45MP0003787_abnormal_imprinting1.45204286
46MP0002066_abnormal_motor_capabilities/c1.41563859
47MP0002653_abnormal_ependyma_morphology1.35092056
48MP0002102_abnormal_ear_morphology1.34139128
49MP0004142_abnormal_muscle_tone1.32671880
50MP0001502_abnormal_circadian_rhythm1.30681486
51MP0006292_abnormal_olfactory_placode1.29642941
52MP0000751_myopathy1.24225533
53MP0001188_hyperpigmentation1.17130070
54MP0004885_abnormal_endolymph1.15205435
55MP0002152_abnormal_brain_morphology1.12505117
56MP0003633_abnormal_nervous_system1.09088414
57MP0003123_paternal_imprinting1.08914001
58MP0005187_abnormal_penis_morphology1.02508585
59MP0004133_heterotaxia1.00708922
60MP0002069_abnormal_eating/drinking_beha1.00239857
61MP0008789_abnormal_olfactory_epithelium0.97628321
62MP0010386_abnormal_urinary_bladder0.97066954
63MP0003631_nervous_system_phenotype0.96049527
64MP0004147_increased_porphyrin_level0.93735597
65MP0002837_dystrophic_cardiac_calcinosis0.93542927
66MP0001485_abnormal_pinna_reflex0.93043075
67MP0005499_abnormal_olfactory_system0.92753359
68MP0005394_taste/olfaction_phenotype0.92753359
69MP0002229_neurodegeneration0.92414280
70MP0008872_abnormal_physiological_respon0.89018189
71MP0000013_abnormal_adipose_tissue0.87763621
72MP0004145_abnormal_muscle_electrophysio0.86961314
73MP0002234_abnormal_pharynx_morphology0.86845475
74MP0004742_abnormal_vestibular_system0.86456916
75MP0000631_abnormal_neuroendocrine_gland0.84741842
76MP0002752_abnormal_somatic_nervous0.84739733
77MP0004085_abnormal_heartbeat0.84708884
78MP0008874_decreased_physiological_sensi0.83654607
79MP0001963_abnormal_hearing_physiology0.81756432
80MP0005551_abnormal_eye_electrophysiolog0.81622528
81MP0008961_abnormal_basal_metabolism0.81112040
82MP0003938_abnormal_ear_development0.79665155
83MP0003634_abnormal_glial_cell0.78531250
84MP0000049_abnormal_middle_ear0.76164116
85MP0005535_abnormal_body_temperature0.74929917
86MP0003878_abnormal_ear_physiology0.74809391
87MP0005377_hearing/vestibular/ear_phenot0.74809391
88MP0000604_amyloidosis0.73109378
89MP0003137_abnormal_impulse_conducting0.72072166
90MP0003690_abnormal_glial_cell0.71128046
91MP0004215_abnormal_myocardial_fiber0.71075430
92MP0005410_abnormal_fertilization0.70844492
93MP0005253_abnormal_eye_physiology0.69864866
94MP0003698_abnormal_male_reproductive0.69830753
95MP0002638_abnormal_pupillary_reflex0.69653097
96MP0001177_atelectasis0.69643830
97MP0003121_genomic_imprinting0.69540020
98MP0002090_abnormal_vision0.67247302
99MP0003632_abnormal_nervous_system0.65702947
100MP0006072_abnormal_retinal_apoptosis0.64427426
101MP0005409_darkened_coat_color0.64307800
102MP0001664_abnormal_digestion0.63499612
103MP0005195_abnormal_posterior_eye0.63133633
104MP0004233_abnormal_muscle_weight0.62346540
105MP0003861_abnormal_nervous_system0.61221712
106MP0002876_abnormal_thyroid_physiology0.58394401
107MP0002751_abnormal_autonomic_nervous0.58347515
108MP0009379_abnormal_foot_pigmentation0.58312293
109MP0004130_abnormal_muscle_cell0.58065251
110MP0003283_abnormal_digestive_organ0.57564590
111MP0002249_abnormal_larynx_morphology0.57364641
112MP0001986_abnormal_taste_sensitivity0.57101172
113MP0005623_abnormal_meninges_morphology0.56464466
114MP0004484_altered_response_of0.55552183
115MP0001943_abnormal_respiration0.55231307
116MP0003956_abnormal_body_size0.52544526
117MP0010769_abnormal_survival0.52261266
118MP0000920_abnormal_myelination0.52177417
119MP0002082_postnatal_lethality0.52098920
120MP0010770_preweaning_lethality0.52098920
121MP0000569_abnormal_digit_pigmentation0.51669060
122MP0000026_abnormal_inner_ear0.51170339
123MP0003075_altered_response_to0.50810217
124MP0001299_abnormal_eye_distance/0.50228172

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.42663724
2Focal motor seizures (HP:0011153)7.04685227
3Focal seizures (HP:0007359)5.53487091
4Visual hallucinations (HP:0002367)5.20803241
5Epileptic encephalopathy (HP:0200134)4.81663465
6Atonic seizures (HP:0010819)4.68709640
7Febrile seizures (HP:0002373)4.34370726
8Absence seizures (HP:0002121)4.23003656
9Progressive cerebellar ataxia (HP:0002073)4.13155429
10Dialeptic seizures (HP:0011146)3.79183228
11Generalized tonic-clonic seizures (HP:0002069)3.69953598
12Action tremor (HP:0002345)3.56948587
13Ankle clonus (HP:0011448)3.51226937
14Impaired vibration sensation in the lower limbs (HP:0002166)3.38629425
15Abnormal eating behavior (HP:0100738)3.38567312
16Polyphagia (HP:0002591)3.37037750
17Supranuclear gaze palsy (HP:0000605)3.33369185
18Amblyopia (HP:0000646)3.20264387
19Mutism (HP:0002300)3.19458805
20Limb dystonia (HP:0002451)3.11523101
21Broad-based gait (HP:0002136)3.09563186
22Depression (HP:0000716)3.09385150
23Poor eye contact (HP:0000817)3.08724692
24Anxiety (HP:0000739)3.08058105
25Pheochromocytoma (HP:0002666)3.03614556
26Truncal ataxia (HP:0002078)2.90382776
27Hyperventilation (HP:0002883)2.86955964
28Urinary bladder sphincter dysfunction (HP:0002839)2.85558279
29Failure to thrive in infancy (HP:0001531)2.83354583
30Progressive inability to walk (HP:0002505)2.82230270
31Abnormality of the lower motor neuron (HP:0002366)2.82171818
32Impaired social interactions (HP:0000735)2.77139880
33Abnormal social behavior (HP:0012433)2.77139880
34Dysdiadochokinesis (HP:0002075)2.76067036
35Urinary urgency (HP:0000012)2.74210558
36Neuroendocrine neoplasm (HP:0100634)2.71004878
37Gaze-evoked nystagmus (HP:0000640)2.70700524
38Dysmetria (HP:0001310)2.70304655
39Medial flaring of the eyebrow (HP:0010747)2.65112500
40Torticollis (HP:0000473)2.65080639
41Insidious onset (HP:0003587)2.64526178
42Termporal pattern (HP:0011008)2.64526178
43Papilledema (HP:0001085)2.61517676
44Drooling (HP:0002307)2.58879153
45Excessive salivation (HP:0003781)2.58879153
46Spastic gait (HP:0002064)2.58562115
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.55974515
48Epileptiform EEG discharges (HP:0011182)2.52050323
49Cerebral hypomyelination (HP:0006808)2.50681834
50Focal dystonia (HP:0004373)2.47194049
51EEG with generalized epileptiform discharges (HP:0011198)2.44909387
52Pancreatic fibrosis (HP:0100732)2.41388113
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.39008323
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39008323
55Congenital stationary night blindness (HP:0007642)2.36535719
56Abnormality of the corticospinal tract (HP:0002492)2.36065232
57Absent/shortened dynein arms (HP:0200106)2.34921145
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.34921145
59Genetic anticipation (HP:0003743)2.34679350
60Congenital primary aphakia (HP:0007707)2.34289484
61Abnormality of macular pigmentation (HP:0008002)2.33920557
62Hypsarrhythmia (HP:0002521)2.32895454
63Molar tooth sign on MRI (HP:0002419)2.32500286
64Abnormality of midbrain morphology (HP:0002418)2.32500286
65Cerebral inclusion bodies (HP:0100314)2.32251235
66Megalencephaly (HP:0001355)2.30665510
67Amyotrophic lateral sclerosis (HP:0007354)2.29993591
68Inability to walk (HP:0002540)2.29414957
69Spastic tetraplegia (HP:0002510)2.27419235
70Postural instability (HP:0002172)2.27225044
71Craniofacial dystonia (HP:0012179)2.25504193
72Hemiparesis (HP:0001269)2.24626771
73Agitation (HP:0000713)2.23809387
74Stereotypic behavior (HP:0000733)2.23650099
75Diplopia (HP:0000651)2.23062663
76Abnormality of binocular vision (HP:0011514)2.23062663
77Sleep apnea (HP:0010535)2.22137256
78Lower limb muscle weakness (HP:0007340)2.20699710
79Neurofibrillary tangles (HP:0002185)2.19023214
80Fetal akinesia sequence (HP:0001989)2.18698593
81True hermaphroditism (HP:0010459)2.18234016
82Scanning speech (HP:0002168)2.18101015
83Bradykinesia (HP:0002067)2.17321954
84Abnormal rod and cone electroretinograms (HP:0008323)2.17321423
85Nephrogenic diabetes insipidus (HP:0009806)2.17128166
86Poor suck (HP:0002033)2.16687511
87Delusions (HP:0000746)2.14279050
88Impaired smooth pursuit (HP:0007772)2.14097577
89Type II lissencephaly (HP:0007260)2.13638658
90Hypoventilation (HP:0002791)2.13393394
91Ventricular fibrillation (HP:0001663)2.11348889
92Peripheral hypomyelination (HP:0007182)2.10706192
93Abnormal hair whorl (HP:0010721)2.10145813
94Impaired vibratory sensation (HP:0002495)2.09903643
95Absent speech (HP:0001344)2.08409484
96Aplasia/Hypoplasia of the brainstem (HP:0007362)2.08026064
97Hypoplasia of the brainstem (HP:0002365)2.08026064
98Status epilepticus (HP:0002133)2.07601123
99Tetraplegia (HP:0002445)2.06010005
100Specific learning disability (HP:0001328)2.04459367
101Lissencephaly (HP:0001339)2.04034556
102Nephronophthisis (HP:0000090)2.02916896
103Severe visual impairment (HP:0001141)2.02324174
104Gait imbalance (HP:0002141)2.01266835
105Optic nerve hypoplasia (HP:0000609)1.99262496
106Neoplasm of the peripheral nervous system (HP:0100007)1.98714207
107Incomplete penetrance (HP:0003829)1.98333998
108Esotropia (HP:0000565)1.97648750
109Psychosis (HP:0000709)1.95437885
110Abnormal respiratory motile cilium morphology (HP:0005938)1.94828743
111Abnormal respiratory epithelium morphology (HP:0012253)1.94828743
112Generalized myoclonic seizures (HP:0002123)1.93787232
113Morphological abnormality of the pyramidal tract (HP:0002062)1.92091151
114Annular pancreas (HP:0001734)1.91971831
115Impaired pain sensation (HP:0007328)1.91787781
116Abnormality of pain sensation (HP:0010832)1.91787781
117Retinal dysplasia (HP:0007973)1.90393843
118Genital tract atresia (HP:0001827)1.88906780
119Neuronal loss in central nervous system (HP:0002529)1.88905198
120Abnormality of ocular smooth pursuit (HP:0000617)1.87063626
121Vaginal atresia (HP:0000148)1.83415910
122Generalized hypotonia (HP:0001290)1.83250450
123Intention tremor (HP:0002080)1.79841352
124Pancreatic cysts (HP:0001737)1.79376900
125Pointed chin (HP:0000307)1.78964122
126Clonus (HP:0002169)1.78873147
127Oligodactyly (hands) (HP:0001180)1.78693522
128Pachygyria (HP:0001302)1.78127972
129Hypoplasia of the corpus callosum (HP:0002079)1.77399983
130Hemiplegia (HP:0002301)1.76212776
131Rapidly progressive (HP:0003678)1.75999751
132Dysmetric saccades (HP:0000641)1.75655756
133Akinesia (HP:0002304)1.73423860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.30001786
2NTRK34.04954274
3EPHA43.75040425
4MARK13.33607711
5MINK12.94035901
6MAP3K122.80007117
7MAP3K42.62449589
8KSR22.37730870
9MAP2K72.20841646
10CAMKK22.19643512
11DAPK22.19031517
12ARAF2.18192645
13PAK62.07813786
14KSR12.02031041
15NTRK22.00623886
16CAMKK11.98933085
17MAP4K21.88207957
18MAP2K41.80806193
19CASK1.79395558
20GRK51.75695360
21RIPK41.70361430
22PRKD31.63770524
23PLK21.55768945
24NTRK11.54805056
25CDK51.49981521
26DAPK11.49676399
27MAPK131.48341150
28CDK191.43958159
29PRPF4B1.40168613
30PNCK1.39392939
31SIK21.36010251
32UHMK11.33954296
33SIK31.25618746
34PRKCG1.24664221
35ADRBK21.18818003
36MAP3K131.14886066
37PHKG21.12080919
38PHKG11.12080919
39CDK181.10866701
40CDK141.10204729
41LATS21.07094349
42CAMK1G1.05604195
43WNK31.04675846
44CDK151.04597822
45CSNK1A1L1.04146228
46LIMK11.01230461
47MAP3K21.00699693
48NME10.99312925
49CSNK1G10.96418717
50TYRO30.95553427
51TNIK0.95200430
52CAMK2A0.94371409
53RAF10.94226509
54CDK11A0.92607728
55FES0.92122872
56FRK0.91788399
57PKN10.88236211
58STK380.85911752
59TAOK10.85224441
60CAMK10.81599687
61CAMK2B0.80967157
62PAK30.80005357
63EPHB20.78897092
64CSNK1G20.75008717
65RET0.74076780
66LMTK20.74063913
67MAPK150.72277095
68CAMK1D0.71711649
69SGK2230.71606672
70SGK4940.71606672
71PTK2B0.68631089
72BCR0.68535756
73DYRK1A0.67203147
74BRAF0.65426460
75STK110.63275040
76BMPR20.62753407
77NEK10.62307158
78DYRK1B0.61378690
79OXSR10.60822702
80PRKCH0.59597070
81DYRK30.59192085
82PRKCZ0.57500627
83TRIM280.57065303
84PRKACA0.56487945
85FER0.56255702
86MAP3K10.56133074
87MARK20.55963359
88TIE10.54771958
89PRKCE0.52148058
90MAP2K10.51241726
91PDPK10.49999371
92SGK10.48530924
93BMPR1B0.48108319
94CAMK2D0.47891200
95MAP3K110.47674613
96GRK10.46831813
97PDK10.46691788
98CAMK40.46204901
99ERBB30.44884189
100SGK20.44567329
101PINK10.44357078
102CAMK2G0.44009546
103DAPK30.44003065
104BRD40.43808850
105DYRK20.43590823
106PRKG10.43242711
107MAPKAPK50.40513932
108CSNK1A10.39940299
109CSNK1D0.39907112
110ADRBK10.39714078
111PRKCA0.38524029
112BCKDK0.37750727
113CSNK1E0.36157038
114RPS6KA20.36067124
115INSRR0.35851860
116WNK40.34821243
117ALK0.34690005
118FYN0.34573960
119RPS6KA30.34487080
120TESK10.34430883
121STK160.33781614
122CSNK1G30.32944663
123CCNB10.32515435
124MAPK100.31784207
125TNK20.31278577
126BRSK10.31063334
127FGR0.30979888
128ROCK20.30097211

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77282716
2Synaptic vesicle cycle_Homo sapiens_hsa047213.71716579
3Olfactory transduction_Homo sapiens_hsa047402.70130922
4GABAergic synapse_Homo sapiens_hsa047272.69595896
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63398446
6Circadian entrainment_Homo sapiens_hsa047132.60187519
7Long-term potentiation_Homo sapiens_hsa047202.59828248
8Glutamatergic synapse_Homo sapiens_hsa047242.45963071
9Morphine addiction_Homo sapiens_hsa050322.44638025
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38386831
11Amphetamine addiction_Homo sapiens_hsa050312.36411156
12Dopaminergic synapse_Homo sapiens_hsa047282.27907196
13Salivary secretion_Homo sapiens_hsa049701.99150426
14Collecting duct acid secretion_Homo sapiens_hsa049661.98998332
15Cholinergic synapse_Homo sapiens_hsa047251.93646946
16Insulin secretion_Homo sapiens_hsa049111.92397149
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88904562
18Taste transduction_Homo sapiens_hsa047421.82049651
19Serotonergic synapse_Homo sapiens_hsa047261.72954851
20Cocaine addiction_Homo sapiens_hsa050301.70456417
21Gastric acid secretion_Homo sapiens_hsa049711.69985772
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67461695
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65815378
24Long-term depression_Homo sapiens_hsa047301.64877537
25Oxytocin signaling pathway_Homo sapiens_hsa049211.64713909
26Renin secretion_Homo sapiens_hsa049241.60233124
27Cardiac muscle contraction_Homo sapiens_hsa042601.52519851
28Calcium signaling pathway_Homo sapiens_hsa040201.48423844
29Gap junction_Homo sapiens_hsa045401.43503315
30GnRH signaling pathway_Homo sapiens_hsa049121.39516947
31Vibrio cholerae infection_Homo sapiens_hsa051101.33961731
32Butanoate metabolism_Homo sapiens_hsa006501.33881281
33Oxidative phosphorylation_Homo sapiens_hsa001901.33698639
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31319843
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22285026
36Axon guidance_Homo sapiens_hsa043601.21289485
37Parkinsons disease_Homo sapiens_hsa050121.18289996
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17188215
39Alzheimers disease_Homo sapiens_hsa050101.13790752
40cAMP signaling pathway_Homo sapiens_hsa040241.09798276
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08465566
42Glioma_Homo sapiens_hsa052141.08388615
43Estrogen signaling pathway_Homo sapiens_hsa049151.07219618
44Melanogenesis_Homo sapiens_hsa049161.02960944
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01125591
46Oocyte meiosis_Homo sapiens_hsa041140.99606083
47ErbB signaling pathway_Homo sapiens_hsa040120.97485470
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95653360
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92125736
50Type II diabetes mellitus_Homo sapiens_hsa049300.91010321
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89733995
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87681567
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.84348105
54beta-Alanine metabolism_Homo sapiens_hsa004100.83040035
55Phototransduction_Homo sapiens_hsa047440.82801292
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81405607
57Huntingtons disease_Homo sapiens_hsa050160.78622217
58Vitamin B6 metabolism_Homo sapiens_hsa007500.75793998
59Fatty acid biosynthesis_Homo sapiens_hsa000610.74807805
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.74386756
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71080470
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70042972
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69540982
64VEGF signaling pathway_Homo sapiens_hsa043700.69134805
65Dilated cardiomyopathy_Homo sapiens_hsa054140.66815102
66Pancreatic secretion_Homo sapiens_hsa049720.66395334
67Dorso-ventral axis formation_Homo sapiens_hsa043200.64616510
68Thyroid hormone synthesis_Homo sapiens_hsa049180.64475388
69Choline metabolism in cancer_Homo sapiens_hsa052310.64309480
70Alcoholism_Homo sapiens_hsa050340.63777097
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.63564886
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63129272
73MAPK signaling pathway_Homo sapiens_hsa040100.62551683
74Nitrogen metabolism_Homo sapiens_hsa009100.61105811
75Circadian rhythm_Homo sapiens_hsa047100.59041986
76Hedgehog signaling pathway_Homo sapiens_hsa043400.55872731
77Ras signaling pathway_Homo sapiens_hsa040140.55014173
78Glucagon signaling pathway_Homo sapiens_hsa049220.53467105
79Regulation of autophagy_Homo sapiens_hsa041400.52939101
80Prion diseases_Homo sapiens_hsa050200.51620778
81Rap1 signaling pathway_Homo sapiens_hsa040150.51249289
82Type I diabetes mellitus_Homo sapiens_hsa049400.50729809
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.50475681
84Endocytosis_Homo sapiens_hsa041440.50166940
85Endometrial cancer_Homo sapiens_hsa052130.48173868
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47855396
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46940654
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46872775
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45110178
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44542639
91Arginine and proline metabolism_Homo sapiens_hsa003300.43747572
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42876649
93Renal cell carcinoma_Homo sapiens_hsa052110.42319818
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41529876
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41079312
96mTOR signaling pathway_Homo sapiens_hsa041500.41044154
97Insulin signaling pathway_Homo sapiens_hsa049100.40914343
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40028823
99Non-small cell lung cancer_Homo sapiens_hsa052230.38162383
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37079731
101Peroxisome_Homo sapiens_hsa041460.36564850
102Steroid biosynthesis_Homo sapiens_hsa001000.36191687
103Ether lipid metabolism_Homo sapiens_hsa005650.36172704
104Wnt signaling pathway_Homo sapiens_hsa043100.35949657
105Ovarian steroidogenesis_Homo sapiens_hsa049130.35710205
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34611864
107Inositol phosphate metabolism_Homo sapiens_hsa005620.34244257
108Fatty acid elongation_Homo sapiens_hsa000620.32570042
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32438035
110Phenylalanine metabolism_Homo sapiens_hsa003600.31583702
111Tryptophan metabolism_Homo sapiens_hsa003800.31369203
112Hippo signaling pathway_Homo sapiens_hsa043900.30915618
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30207699
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29820549
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29538818
116Rheumatoid arthritis_Homo sapiens_hsa053230.29463979
117Bile secretion_Homo sapiens_hsa049760.29048029
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28915283
119Colorectal cancer_Homo sapiens_hsa052100.28660590
120Basal cell carcinoma_Homo sapiens_hsa052170.28459412
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28040474
122Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27852445
123Chemokine signaling pathway_Homo sapiens_hsa040620.27161003
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26168616

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »