

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | L-phenylalanine catabolic process (GO:0006559) | 7.55273429 |
| 2 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 7.55273429 |
| 3 | L-phenylalanine metabolic process (GO:0006558) | 7.24230773 |
| 4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 7.24230773 |
| 5 | aromatic amino acid family catabolic process (GO:0009074) | 6.77255130 |
| 6 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 6.56622101 |
| 7 | tryptophan catabolic process (GO:0006569) | 6.12504564 |
| 8 | indole-containing compound catabolic process (GO:0042436) | 6.12504564 |
| 9 | indolalkylamine catabolic process (GO:0046218) | 6.12504564 |
| 10 | kynurenine metabolic process (GO:0070189) | 6.03338401 |
| 11 | bile acid biosynthetic process (GO:0006699) | 5.97407789 |
| 12 | negative regulation of fibrinolysis (GO:0051918) | 5.93635351 |
| 13 | glyoxylate metabolic process (GO:0046487) | 5.90954756 |
| 14 | regulation of plasminogen activation (GO:0010755) | 5.86655624 |
| 15 | high-density lipoprotein particle remodeling (GO:0034375) | 5.82600261 |
| 16 | regulation of fibrinolysis (GO:0051917) | 5.75529461 |
| 17 | tryptophan metabolic process (GO:0006568) | 5.75300661 |
| 18 | urea cycle (GO:0000050) | 5.64357348 |
| 19 | urea metabolic process (GO:0019627) | 5.64357348 |
| 20 | regulation of protein activation cascade (GO:2000257) | 5.62893526 |
| 21 | complement activation, alternative pathway (GO:0006957) | 5.56279940 |
| 22 | protein carboxylation (GO:0018214) | 5.54032787 |
| 23 | peptidyl-glutamic acid carboxylation (GO:0017187) | 5.54032787 |
| 24 | alpha-linolenic acid metabolic process (GO:0036109) | 5.50848372 |
| 25 | epoxygenase P450 pathway (GO:0019373) | 5.50433098 |
| 26 | sulfur amino acid catabolic process (GO:0000098) | 5.25506591 |
| 27 | cysteine metabolic process (GO:0006534) | 5.24326576 |
| 28 | regulation of complement activation (GO:0030449) | 5.23670960 |
| 29 | nitrogen cycle metabolic process (GO:0071941) | 5.18457893 |
| 30 | reverse cholesterol transport (GO:0043691) | 5.15001090 |
| 31 | regulation of cholesterol esterification (GO:0010872) | 5.08718881 |
| 32 | serine family amino acid catabolic process (GO:0009071) | 5.06835336 |
| 33 | bile acid metabolic process (GO:0008206) | 5.06326598 |
| 34 | regulation of triglyceride catabolic process (GO:0010896) | 5.02367667 |
| 35 | plasma lipoprotein particle remodeling (GO:0034369) | 4.98820047 |
| 36 | protein-lipid complex remodeling (GO:0034368) | 4.98820047 |
| 37 | macromolecular complex remodeling (GO:0034367) | 4.98820047 |
| 38 | intestinal cholesterol absorption (GO:0030299) | 4.95284092 |
| 39 | aromatic amino acid family metabolic process (GO:0009072) | 4.92030542 |
| 40 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.88736488 |
| 41 | regulation of apoptotic cell clearance (GO:2000425) | 4.84334555 |
| 42 | negative regulation of hemostasis (GO:1900047) | 4.80702942 |
| 43 | negative regulation of blood coagulation (GO:0030195) | 4.80702942 |
| 44 | negative regulation of complement activation (GO:0045916) | 4.79312896 |
| 45 | phospholipid efflux (GO:0033700) | 4.78343001 |
| 46 | tyrosine metabolic process (GO:0006570) | 4.78009114 |
| 47 | triglyceride homeostasis (GO:0070328) | 4.76334556 |
| 48 | acylglycerol homeostasis (GO:0055090) | 4.76334556 |
| 49 | regulation of humoral immune response (GO:0002920) | 4.76319114 |
| 50 | protein-lipid complex subunit organization (GO:0071825) | 4.65843719 |
| 51 | negative regulation of cholesterol transport (GO:0032375) | 4.59841207 |
| 52 | negative regulation of sterol transport (GO:0032372) | 4.59841207 |
| 53 | alpha-amino acid catabolic process (GO:1901606) | 4.56255324 |
| 54 | positive regulation of hemostasis (GO:1900048) | 4.55633453 |
| 55 | positive regulation of blood coagulation (GO:0030194) | 4.55633453 |
| 56 | plasma lipoprotein particle clearance (GO:0034381) | 4.54796172 |
| 57 | homocysteine metabolic process (GO:0050667) | 4.53624385 |
| 58 | amino-acid betaine metabolic process (GO:0006577) | 4.52649048 |
| 59 | cellular ketone body metabolic process (GO:0046950) | 4.52042145 |
| 60 | lysine metabolic process (GO:0006553) | 4.47005999 |
| 61 | lysine catabolic process (GO:0006554) | 4.47005999 |
| 62 | omega-hydroxylase P450 pathway (GO:0097267) | 4.43925625 |
| 63 | negative regulation of coagulation (GO:0050819) | 4.39082326 |
| 64 | cholesterol efflux (GO:0033344) | 4.38506720 |
| 65 | glycine metabolic process (GO:0006544) | 4.36265935 |
| 66 | coenzyme catabolic process (GO:0009109) | 4.35625847 |
| 67 | negative regulation of wound healing (GO:0061045) | 4.32794622 |
| 68 | indolalkylamine metabolic process (GO:0006586) | 4.32630080 |
| 69 | bile acid and bile salt transport (GO:0015721) | 4.29548920 |
| 70 | ethanol metabolic process (GO:0006067) | 4.27246105 |
| 71 | imidazole-containing compound metabolic process (GO:0052803) | 4.26436622 |
| 72 | amine catabolic process (GO:0009310) | 4.23166040 |
| 73 | cellular biogenic amine catabolic process (GO:0042402) | 4.23166040 |
| 74 | fibrinolysis (GO:0042730) | 4.21140866 |
| 75 | glutamate metabolic process (GO:0006536) | 4.20658546 |
| 76 | cellular amino acid catabolic process (GO:0009063) | 4.19318226 |
| 77 | phenylpropanoid metabolic process (GO:0009698) | 4.18796637 |
| 78 | positive regulation of coagulation (GO:0050820) | 4.16852176 |
| 79 | proline metabolic process (GO:0006560) | 4.16698301 |
| 80 | plasma lipoprotein particle assembly (GO:0034377) | 4.13796949 |
| 81 | exogenous drug catabolic process (GO:0042738) | 4.10911990 |
| 82 | serine family amino acid metabolic process (GO:0009069) | 4.10239918 |
| 83 | blood coagulation, intrinsic pathway (GO:0007597) | 4.07615936 |
| 84 | cellular glucuronidation (GO:0052695) | 4.07384627 |
| 85 | benzene-containing compound metabolic process (GO:0042537) | 4.05549771 |
| 86 | arginine metabolic process (GO:0006525) | 4.04434394 |
| 87 | low-density lipoprotein particle remodeling (GO:0034374) | 4.03315055 |
| 88 | positive regulation of triglyceride lipase activity (GO:0061365) | 4.02509387 |
| 89 | positive regulation of lipoprotein lipase activity (GO:0051006) | 4.02509387 |
| 90 | dicarboxylic acid biosynthetic process (GO:0043650) | 4.01118120 |
| 91 | aldehyde catabolic process (GO:0046185) | 4.00097086 |
| 92 | cellular modified amino acid catabolic process (GO:0042219) | 3.99201685 |
| 93 | complement activation, classical pathway (GO:0006958) | 3.94036627 |
| 94 | serine family amino acid biosynthetic process (GO:0009070) | 3.93743660 |
| 95 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 3.92291968 |
| 96 | drug metabolic process (GO:0017144) | 3.92012870 |
| 97 | ketone body metabolic process (GO:1902224) | 3.91254172 |
| 98 | protein activation cascade (GO:0072376) | 3.88985546 |
| 99 | complement activation (GO:0006956) | 3.86895082 |
| 100 | ethanol oxidation (GO:0006069) | 3.86723728 |
| 101 | cytolysis (GO:0019835) | 3.85760817 |
| 102 | negative regulation of lipase activity (GO:0060192) | 3.85344761 |
| 103 | positive regulation of lipid catabolic process (GO:0050996) | 3.80977344 |
| 104 | acute-phase response (GO:0006953) | 3.79672936 |
| 105 | plasma lipoprotein particle organization (GO:0071827) | 3.79198723 |
| 106 | cofactor catabolic process (GO:0051187) | 3.79039659 |
| 107 | phospholipid homeostasis (GO:0055091) | 3.78616723 |
| 108 | cholesterol homeostasis (GO:0042632) | 3.78162953 |
| 109 | negative regulation of humoral immune response (GO:0002921) | 3.77802766 |
| 110 | negative regulation of protein activation cascade (GO:2000258) | 3.73112669 |
| 111 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.71948655 |
| 112 | sterol homeostasis (GO:0055092) | 3.71792297 |
| 113 | very-low-density lipoprotein particle assembly (GO:0034379) | 3.71447763 |
| 114 | protein-lipid complex assembly (GO:0065005) | 3.70180965 |
| 115 | opsonization (GO:0008228) | 3.70175608 |
| 116 | drug catabolic process (GO:0042737) | 3.69788565 |
| 117 | organic acid catabolic process (GO:0016054) | 3.66874680 |
| 118 | carboxylic acid catabolic process (GO:0046395) | 3.66874680 |
| 119 | positive regulation of extracellular matrix organization (GO:1903055) | 3.66862738 |
| 120 | oxidative demethylation (GO:0070989) | 3.65746815 |
| 121 | acute inflammatory response (GO:0002526) | 3.63359801 |
| 122 | regulation of cholesterol homeostasis (GO:2000188) | 3.62436728 |
| 123 | uronic acid metabolic process (GO:0006063) | 3.61829829 |
| 124 | glucuronate metabolic process (GO:0019585) | 3.61829829 |
| 125 | regulation of bile acid biosynthetic process (GO:0070857) | 3.61004748 |
| 126 | heme transport (GO:0015886) | 3.59688323 |
| 127 | lipoprotein metabolic process (GO:0042157) | 3.58106448 |
| 128 | peptidyl-glutamic acid modification (GO:0018200) | 3.56717905 |
| 129 | regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081) | 3.45434821 |
| 130 | cholesterol transport (GO:0030301) | 3.41949848 |
| 131 | sterol transport (GO:0015918) | 3.41949848 |
| 132 | intestinal absorption (GO:0050892) | 3.33347301 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 8.37769507 |
| 2 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 7.19427158 |
| 3 | * EGR1_23403033_ChIP-Seq_LIVER_Mouse | 6.98076952 |
| 4 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 6.47681086 |
| 5 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 5.31424858 |
| 6 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 5.20515389 |
| 7 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.91494348 |
| 8 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 4.04257769 |
| 9 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 4.02879079 |
| 10 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 2.04710470 |
| 11 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 2.01917768 |
| 12 | * ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 12.0408211 |
| 13 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.94159598 |
| 14 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.86699534 |
| 15 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.59668371 |
| 16 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.53893907 |
| 17 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.49359910 |
| 18 | GATA1_22025678_ChIP-Seq_K562_Human | 1.45183777 |
| 19 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.44543501 |
| 20 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.43152707 |
| 21 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.42779898 |
| 22 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.39173471 |
| 23 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.34707629 |
| 24 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.28316110 |
| 25 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.23938279 |
| 26 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 1.22375685 |
| 27 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.13454653 |
| 28 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.12919623 |
| 29 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.05138672 |
| 30 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.03878866 |
| 31 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.03129411 |
| 32 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 1.01053540 |
| 33 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.00074845 |
| 34 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.91954292 |
| 35 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.91933167 |
| 36 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.88358431 |
| 37 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.87856584 |
| 38 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.87340254 |
| 39 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 0.84887079 |
| 40 | FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.84847025 |
| 41 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.83267027 |
| 42 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.83100442 |
| 43 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.82592773 |
| 44 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.81266151 |
| 45 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.80006100 |
| 46 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.79222354 |
| 47 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.78552795 |
| 48 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.77905450 |
| 49 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.76388554 |
| 50 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.76257509 |
| 51 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.75804961 |
| 52 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.75178331 |
| 53 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.74385832 |
| 54 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.72608488 |
| 55 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.70238385 |
| 56 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.69824647 |
| 57 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.69013866 |
| 58 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.67876171 |
| 59 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.67531730 |
| 60 | SOX2_21211035_ChIP-Seq_LN229_Human | 0.67452116 |
| 61 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.67066555 |
| 62 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.66842546 |
| 63 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.66842029 |
| 64 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 0.65913089 |
| 65 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.65622314 |
| 66 | SMAD1_18555785_Chip-Seq_ESCs_Mouse | 0.65404686 |
| 67 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.65237688 |
| 68 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.64346283 |
| 69 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.64152048 |
| 70 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.63710977 |
| 71 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.63666436 |
| 72 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.62365378 |
| 73 | BMI1_19503595_ChIP-Seq_MEFsC_Mouse | 0.61948315 |
| 74 | * RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.61735771 |
| 75 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.61725005 |
| 76 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.61725005 |
| 77 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.61321191 |
| 78 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.61098041 |
| 79 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.60254274 |
| 80 | JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse | 0.59568911 |
| 81 | ESRRB_18555785_Chip-Seq_ESCs_Mouse | 0.59065716 |
| 82 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.58797268 |
| 83 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 0.57966188 |
| 84 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.56905709 |
| 85 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 0.56887560 |
| 86 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.56699330 |
| 87 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.56678935 |
| 88 | SOX11_22085726_ChIP-Seq_ESNs_Mouse | 0.56579876 |
| 89 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.55651492 |
| 90 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.54842075 |
| 91 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.53989618 |
| 92 | ZFX_18555785_Chip-Seq_ESCs_Mouse | 0.53777863 |
| 93 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.53333853 |
| 94 | MYC_19915707_ChIP-ChIP_AK7_Human | 0.53046711 |
| 95 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.52974992 |
| 96 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.52865985 |
| 97 | AR_20517297_ChIP-Seq_VCAP_Human | 0.52417088 |
| 98 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.50930223 |
| 99 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.50818455 |
| 100 | PU1_27457419_Chip-Seq_LIVER_Mouse | 0.48764845 |
| 101 | ESET_19884257_ChIP-Seq_ESCs_Mouse | 0.48587727 |
| 102 | FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.48397786 |
| 103 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 0.48245030 |
| 104 | * FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.47932236 |
| 105 | P53_21459846_ChIP-Seq_SAOS-2_Human | 0.46713430 |
| 106 | CBP_21632823_ChIP-Seq_H3396_Human | 0.46303620 |
| 107 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.44831032 |
| 108 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.44766817 |
| 109 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.44172669 |
| 110 | CDX2_20551321_ChIP-Seq_CACO-2_Human | 0.44028754 |
| 111 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.43977559 |
| 112 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.43655078 |
| 113 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.43172538 |
| 114 | GATA1_19941826_ChIP-Seq_K562_Human | 0.42492439 |
| 115 | * TAF2_19829295_ChIP-Seq_ESCs_Human | 0.41840713 |
| 116 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.41592519 |
| 117 | * STAT1_17558387_ChIP-Seq_HELA_Human | 0.41081004 |
| 118 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.40035894 |
| 119 | GATA2_19941826_ChIP-Seq_K562_Human | 0.39673819 |
| 120 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.39267511 |
| 121 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.37883932 |
| 122 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.37443428 |
| 123 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.36794272 |
| 124 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.36417496 |
| 125 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.36283026 |
| 126 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 0.35769570 |
| 127 | SPI1_26923725_Chip-Seq_HPCs_Mouse | 0.35619771 |
| 128 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.35529248 |
| 129 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.35304722 |
| 130 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 0.34971189 |
| 131 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.34596661 |
| 132 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.34497607 |
| 133 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.34453570 |
| 134 | NCOR_22424771_ChIP-Seq_293T_Human | 0.34355573 |
| 135 | * FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.34352298 |
| 136 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.34125750 |
| 137 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.33987177 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002139_abnormal_hepatobiliary_system | 8.24023001 |
| 2 | MP0005360_urolithiasis | 7.52185343 |
| 3 | MP0005085_abnormal_gallbladder_physiolo | 6.40357224 |
| 4 | MP0005365_abnormal_bile_salt | 6.11553319 |
| 5 | MP0008875_abnormal_xenobiotic_pharmacok | 4.92615428 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 4.35862037 |
| 7 | MP0003252_abnormal_bile_duct | 3.85100262 |
| 8 | MP0010329_abnormal_lipoprotein_level | 3.66516119 |
| 9 | MP0009840_abnormal_foam_cell | 3.43841058 |
| 10 | MP0005083_abnormal_biliary_tract | 3.03032835 |
| 11 | MP0003122_maternal_imprinting | 2.96076601 |
| 12 | MP0003195_calcinosis | 2.85323862 |
| 13 | MP0005332_abnormal_amino_acid | 2.73585148 |
| 14 | MP0003191_abnormal_cellular_cholesterol | 2.62131111 |
| 15 | MP0001666_abnormal_nutrient_absorption | 2.60982308 |
| 16 | MP0000609_abnormal_liver_physiology | 2.18418459 |
| 17 | MP0002118_abnormal_lipid_homeostasis | 2.10938854 |
| 18 | MP0004019_abnormal_vitamin_homeostasis | 2.07205854 |
| 19 | MP0002138_abnormal_hepatobiliary_system | 1.96125159 |
| 20 | MP0003868_abnormal_feces_composition | 1.91734941 |
| 21 | MP0005319_abnormal_enzyme/_coenzyme | 1.83355339 |
| 22 | MP0001915_intracranial_hemorrhage | 1.70809329 |
| 23 | MP0001764_abnormal_homeostasis | 1.65770762 |
| 24 | MP0009697_abnormal_copulation | 1.61555765 |
| 25 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.57595051 |
| 26 | MP0003011_delayed_dark_adaptation | 1.43940156 |
| 27 | MP0005451_abnormal_body_composition | 1.39839260 |
| 28 | MP0002089_abnormal_postnatal_growth/wei | 1.38201560 |
| 29 | MP0003656_abnormal_erythrocyte_physiolo | 1.37987345 |
| 30 | MP0000566_synostosis | 1.36048572 |
| 31 | MP0003123_paternal_imprinting | 1.35044098 |
| 32 | MP0005058_abnormal_lysosome_morphology | 1.34839409 |
| 33 | MP0003186_abnormal_redox_activity | 1.24400038 |
| 34 | MP0009643_abnormal_urine_homeostasis | 1.21306324 |
| 35 | MP0003705_abnormal_hypodermis_morpholog | 1.19628342 |
| 36 | MP0000598_abnormal_liver_morphology | 1.18914930 |
| 37 | MP0005647_abnormal_sex_gland | 1.17566856 |
| 38 | MP0000604_amyloidosis | 1.17391861 |
| 39 | MP0003172_abnormal_lysosome_physiology | 1.11037002 |
| 40 | MP0010368_abnormal_lymphatic_system | 1.10016541 |
| 41 | MP0002254_reproductive_system_inflammat | 1.08340147 |
| 42 | MP0009764_decreased_sensitivity_to | 1.07064961 |
| 43 | MP0009763_increased_sensitivity_to | 1.04493442 |
| 44 | MP0005636_abnormal_mineral_homeostasis | 0.95792671 |
| 45 | MP0008469_abnormal_protein_level | 0.92730536 |
| 46 | MP0009642_abnormal_blood_homeostasis | 0.88797270 |
| 47 | MP0005408_hypopigmentation | 0.84319343 |
| 48 | MP0006036_abnormal_mitochondrial_physio | 0.81979509 |
| 49 | MP0005376_homeostasis/metabolism_phenot | 0.81586778 |
| 50 | MP0002876_abnormal_thyroid_physiology | 0.78481766 |
| 51 | MP0005167_abnormal_blood-brain_barrier | 0.78054379 |
| 52 | MP0002078_abnormal_glucose_homeostasis | 0.77725224 |
| 53 | MP0009765_abnormal_xenobiotic_induced | 0.77259298 |
| 54 | MP0005084_abnormal_gallbladder_morpholo | 0.75588057 |
| 55 | MP0005670_abnormal_white_adipose | 0.75484363 |
| 56 | MP0004272_abnormal_basement_membrane | 0.72588961 |
| 57 | MP0005220_abnormal_exocrine_pancreas | 0.71838009 |
| 58 | MP0002971_abnormal_brown_adipose | 0.70203444 |
| 59 | MP0003121_genomic_imprinting | 0.68975143 |
| 60 | MP0003690_abnormal_glial_cell | 0.68925467 |
| 61 | MP0005535_abnormal_body_temperature | 0.68586168 |
| 62 | MP0009053_abnormal_anal_canal | 0.67993185 |
| 63 | MP0003879_abnormal_hair_cell | 0.67765657 |
| 64 | MP0005334_abnormal_fat_pad | 0.67632886 |
| 65 | MP0004130_abnormal_muscle_cell | 0.66757869 |
| 66 | MP0005266_abnormal_metabolism | 0.65253087 |
| 67 | MP0002282_abnormal_trachea_morphology | 0.64850484 |
| 68 | MP0001661_extended_life_span | 0.64413746 |
| 69 | MP0000639_abnormal_adrenal_gland | 0.64268281 |
| 70 | MP0003329_amyloid_beta_deposits | 0.61991259 |
| 71 | MP0003567_abnormal_fetal_cardiomyocyte | 0.61096765 |
| 72 | MP0005464_abnormal_platelet_physiology | 0.60702585 |
| 73 | MP0005409_darkened_coat_color | 0.60447421 |
| 74 | MP0006054_spinal_hemorrhage | 0.59880536 |
| 75 | MP0005187_abnormal_penis_morphology | 0.57567444 |
| 76 | MP0003183_abnormal_peptide_metabolism | 0.56902160 |
| 77 | MP0001756_abnormal_urination | 0.56664960 |
| 78 | MP0005257_abnormal_intraocular_pressure | 0.56590327 |
| 79 | MP0006035_abnormal_mitochondrial_morpho | 0.55235058 |
| 80 | MP0005448_abnormal_energy_balance | 0.54619042 |
| 81 | MP0005395_other_phenotype | 0.50687154 |
| 82 | MP0002822_catalepsy | 0.49402832 |
| 83 | MP0003950_abnormal_plasma_membrane | 0.49148020 |
| 84 | MP0002090_abnormal_vision | 0.46459184 |
| 85 | MP0003638_abnormal_response/metabolism_ | 0.46436532 |
| 86 | MP0003075_altered_response_to | 0.46436338 |
| 87 | MP0003436_decreased_susceptibility_to | 0.46123143 |
| 88 | MP0009780_abnormal_chondrocyte_physiolo | 0.46074979 |
| 89 | MP0008874_decreased_physiological_sensi | 0.45821003 |
| 90 | MP0003718_maternal_effect | 0.45738203 |
| 91 | MP0003724_increased_susceptibility_to | 0.45207877 |
| 92 | MP0002933_joint_inflammation | 0.44612176 |
| 93 | MP0002938_white_spotting | 0.44481517 |
| 94 | MP0001324_abnormal_eye_pigmentation | 0.44367116 |
| 95 | MP0005166_decreased_susceptibility_to | 0.44331393 |
| 96 | MP0008873_increased_physiological_sensi | 0.44310081 |
| 97 | MP0002136_abnormal_kidney_physiology | 0.44283706 |
| 98 | MP0002837_dystrophic_cardiac_calcinosis | 0.43873016 |
| 99 | MP0004264_abnormal_extraembryonic_tissu | 0.43639308 |
| 100 | MP0005410_abnormal_fertilization | 0.42750055 |
| 101 | MP0002928_abnormal_bile_duct | 0.42696540 |
| 102 | MP0004381_abnormal_hair_follicle | 0.41694800 |
| 103 | MP0003953_abnormal_hormone_level | 0.40073283 |
| 104 | MP0004782_abnormal_surfactant_physiolog | 0.40057751 |
| 105 | MP0000920_abnormal_myelination | 0.39622387 |
| 106 | MP0000579_abnormal_nail_morphology | 0.38237119 |
| 107 | MP0004883_abnormal_blood_vessel | 0.37829584 |
| 108 | MP0003941_abnormal_skin_development | 0.37674942 |
| 109 | MP0005248_abnormal_Harderian_gland | 0.37169870 |
| 110 | MP0006082_CNS_inflammation | 0.36988386 |
| 111 | MP0005666_abnormal_adipose_tissue | 0.36873676 |
| 112 | MP0001270_distended_abdomen | 0.35482140 |
| 113 | MP0003632_abnormal_nervous_system | 0.34978491 |
| 114 | MP0008872_abnormal_physiological_respon | 0.34648755 |
| 115 | MP0000249_abnormal_blood_vessel | 0.34361050 |
| 116 | MP0000003_abnormal_adipose_tissue | 0.34238975 |
| 117 | MP0005377_hearing/vestibular/ear_phenot | 0.33883073 |
| 118 | MP0003878_abnormal_ear_physiology | 0.33883073 |
| 119 | MP0002796_impaired_skin_barrier | 0.33817564 |
| 120 | MP0009384_cardiac_valve_regurgitation | 0.33813076 |
| 121 | MP0009672_abnormal_birth_weight | 0.33400535 |
| 122 | MP0003315_abnormal_perineum_morphology | 0.32327566 |
| 123 | MP0009115_abnormal_fat_cell | 0.31944389 |
| 124 | MP0002132_abnormal_respiratory_system | 0.31530382 |
| 125 | MP0001243_abnormal_dermal_layer | 0.31404025 |
| 126 | MP0002249_abnormal_larynx_morphology | 0.31098089 |
| 127 | MP0000230_abnormal_systemic_arterial | 0.31066367 |
| 128 | MP0001845_abnormal_inflammatory_respons | 0.30147057 |
| 129 | MP0005023_abnormal_wound_healing | 0.30003400 |
| 130 | MP0005164_abnormal_response_to | 0.29995538 |
| 131 | MP0002970_abnormal_white_adipose | 0.29792249 |
| 132 | MP0002168_other_aberrant_phenotype | 0.29195260 |
| 133 | MP0003115_abnormal_respiratory_system | 0.28925570 |
| 134 | MP0001881_abnormal_mammary_gland | 0.28820325 |
| 135 | MP0002092_abnormal_eye_morphology | 0.28294262 |
| 136 | MP0001853_heart_inflammation | 0.27434102 |
| 137 | MP0009379_abnormal_foot_pigmentation | 0.23974440 |
| 138 | MP0000427_abnormal_hair_cycle | 0.23722399 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Deep venous thrombosis (HP:0002625) | 7.57549341 |
| 2 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 7.35649848 |
| 3 | Intrahepatic cholestasis (HP:0001406) | 7.27323666 |
| 4 | Prolonged partial thromboplastin time (HP:0003645) | 6.80652488 |
| 5 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 6.58851054 |
| 6 | Hypobetalipoproteinemia (HP:0003563) | 6.35811541 |
| 7 | Xanthomatosis (HP:0000991) | 6.29847232 |
| 8 | Complement deficiency (HP:0004431) | 5.70300867 |
| 9 | Hyperlipoproteinemia (HP:0010980) | 5.64746241 |
| 10 | Joint hemorrhage (HP:0005261) | 4.97553185 |
| 11 | Hypolipoproteinemia (HP:0010981) | 4.89602765 |
| 12 | Abnormality of the common coagulation pathway (HP:0010990) | 4.74001666 |
| 13 | Hyperammonemia (HP:0001987) | 4.54793387 |
| 14 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 4.45086492 |
| 15 | Hypoalphalipoproteinemia (HP:0003233) | 4.42568372 |
| 16 | Epidermoid cyst (HP:0200040) | 4.36606623 |
| 17 | Hyperglycinemia (HP:0002154) | 4.32464320 |
| 18 | Ketosis (HP:0001946) | 4.19057626 |
| 19 | Abnormality of complement system (HP:0005339) | 4.17703226 |
| 20 | Abnormality of methionine metabolism (HP:0010901) | 4.17488464 |
| 21 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 4.14210645 |
| 22 | Fat malabsorption (HP:0002630) | 4.11209421 |
| 23 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 4.00866585 |
| 24 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.99780313 |
| 25 | Abnormality of the intrinsic pathway (HP:0010989) | 3.92665598 |
| 26 | Hypoglycemic coma (HP:0001325) | 3.83934962 |
| 27 | Abnormality of pyrimidine metabolism (HP:0004353) | 3.78029643 |
| 28 | Abnormality of glycine metabolism (HP:0010895) | 3.77582559 |
| 29 | Abnormality of serine family amino acid metabolism (HP:0010894) | 3.77582559 |
| 30 | Hyperglycinuria (HP:0003108) | 3.76673947 |
| 31 | Conjugated hyperbilirubinemia (HP:0002908) | 3.56967048 |
| 32 | Hypercholesterolemia (HP:0003124) | 3.53078705 |
| 33 | Spontaneous abortion (HP:0005268) | 3.43265851 |
| 34 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.29537439 |
| 35 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.28682121 |
| 36 | Hyperbilirubinemia (HP:0002904) | 3.26668791 |
| 37 | Steatorrhea (HP:0002570) | 3.13175768 |
| 38 | Hypochromic microcytic anemia (HP:0004840) | 3.11208767 |
| 39 | Purpura (HP:0000979) | 3.09291703 |
| 40 | Delayed CNS myelination (HP:0002188) | 3.04569317 |
| 41 | Hepatocellular carcinoma (HP:0001402) | 3.00967407 |
| 42 | Abnormality of nucleobase metabolism (HP:0010932) | 3.00653332 |
| 43 | Abnormality of serum amino acid levels (HP:0003112) | 2.96417639 |
| 44 | Myocardial infarction (HP:0001658) | 2.94615972 |
| 45 | Systemic lupus erythematosus (HP:0002725) | 2.92480974 |
| 46 | Ketoacidosis (HP:0001993) | 2.92027232 |
| 47 | Osteomalacia (HP:0002749) | 2.75601243 |
| 48 | Metabolic acidosis (HP:0001942) | 2.70864792 |
| 49 | Skin nodule (HP:0200036) | 2.69918331 |
| 50 | Abnormality of carpal bone ossification (HP:0006257) | 2.66639154 |
| 51 | Reduced antithrombin III activity (HP:0001976) | 2.65565268 |
| 52 | Abnormality of purine metabolism (HP:0004352) | 2.61965177 |
| 53 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.59300501 |
| 54 | Amyloidosis (HP:0011034) | 2.58541376 |
| 55 | Lethargy (HP:0001254) | 2.56412030 |
| 56 | Vascular calcification (HP:0004934) | 2.55322658 |
| 57 | Glomerulonephritis (HP:0000099) | 2.52524078 |
| 58 | Dicarboxylic aciduria (HP:0003215) | 2.51935511 |
| 59 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.51935511 |
| 60 | Arthropathy (HP:0003040) | 2.51907815 |
| 61 | Acanthocytosis (HP:0001927) | 2.47743304 |
| 62 | Gout (HP:0001997) | 2.46767797 |
| 63 | Gingival bleeding (HP:0000225) | 2.45508564 |
| 64 | Hypoglycemic seizures (HP:0002173) | 2.45393973 |
| 65 | Abnormal tarsal ossification (HP:0008369) | 2.45142796 |
| 66 | Abnormal gallbladder morphology (HP:0012437) | 2.43269019 |
| 67 | Cerebral edema (HP:0002181) | 2.41188881 |
| 68 | Mitral stenosis (HP:0001718) | 2.40390310 |
| 69 | Cholelithiasis (HP:0001081) | 2.40336888 |
| 70 | Spastic diplegia (HP:0001264) | 2.39092040 |
| 71 | Neonatal onset (HP:0003623) | 2.37634477 |
| 72 | Abnormal gallbladder physiology (HP:0012438) | 2.33224703 |
| 73 | Cholecystitis (HP:0001082) | 2.33224703 |
| 74 | Irritability (HP:0000737) | 2.31783898 |
| 75 | Malnutrition (HP:0004395) | 2.31180302 |
| 76 | Cardiovascular calcification (HP:0011915) | 2.26350819 |
| 77 | Menorrhagia (HP:0000132) | 2.24639208 |
| 78 | Thrombophlebitis (HP:0004418) | 2.24356204 |
| 79 | Esophageal varix (HP:0002040) | 2.18125891 |
| 80 | Pancreatitis (HP:0001733) | 2.16258660 |
| 81 | Sensorimotor neuropathy (HP:0007141) | 2.14610192 |
| 82 | Late onset (HP:0003584) | 2.12521245 |
| 83 | Enlarged kidneys (HP:0000105) | 2.12349124 |
| 84 | Increased serum pyruvate (HP:0003542) | 2.12101817 |
| 85 | Broad alveolar ridges (HP:0000187) | 2.11470699 |
| 86 | Potter facies (HP:0002009) | 2.11225955 |
| 87 | Facial shape deformation (HP:0011334) | 2.11225955 |
| 88 | Small epiphyses (HP:0010585) | 2.11184397 |
| 89 | Brushfield spots (HP:0001088) | 2.09745669 |
| 90 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.08725798 |
| 91 | Hemorrhage of the eye (HP:0011885) | 2.07379382 |
| 92 | Vomiting (HP:0002013) | 2.06624720 |
| 93 | Abnormality of the Achilles tendon (HP:0005109) | 2.03305567 |
| 94 | Poikilocytosis (HP:0004447) | 2.01932149 |
| 95 | Opisthotonus (HP:0002179) | 2.01694806 |
| 96 | Abnormality of iron homeostasis (HP:0011031) | 1.98681936 |
| 97 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.98502448 |
| 98 | Abnormality of the gallbladder (HP:0005264) | 1.98138245 |
| 99 | Generalized aminoaciduria (HP:0002909) | 1.97949242 |
| 100 | Abnormal hand bone ossification (HP:0010660) | 1.96464367 |
| 101 | Abnormality of transition element cation homeostasis (HP:0011030) | 1.93592043 |
| 102 | Abnormal ossification of hand bones (HP:0005921) | 1.93377795 |
| 103 | Vaginal fistula (HP:0004320) | 1.91730964 |
| 104 | Asymmetry of the thorax (HP:0001555) | 1.91113768 |
| 105 | Rickets (HP:0002748) | 1.88601509 |
| 106 | Abnormality of glycolysis (HP:0004366) | 1.88231252 |
| 107 | Hypophosphatemic rickets (HP:0004912) | 1.86485201 |
| 108 | Abnormality of the lumbar spine (HP:0100712) | 1.83953677 |
| 109 | Flat acetabular roof (HP:0003180) | 1.83845088 |
| 110 | Elevated hepatic transaminases (HP:0002910) | 1.81098552 |
| 111 | Abnormal cartilage morphology (HP:0002763) | 1.80509386 |
| 112 | Abnormality of the nasal septum (HP:0000419) | 1.80003892 |
| 113 | Status epilepticus (HP:0002133) | 1.79807499 |
| 114 | Epistaxis (HP:0000421) | 1.79549365 |
| 115 | Widely patent fontanelles and sutures (HP:0004492) | 1.79353577 |
| 116 | Nephritis (HP:0000123) | 1.78537416 |
| 117 | Fair hair (HP:0002286) | 1.77131949 |
| 118 | Peritonitis (HP:0002586) | 1.76951633 |
| 119 | Abnormal enzyme/coenzyme activity (HP:0012379) | 1.76553684 |
| 120 | Renal cortical cysts (HP:0000803) | 1.76018427 |
| 121 | Gangrene (HP:0100758) | 1.75533829 |
| 122 | Pulmonary embolism (HP:0002204) | 1.74616658 |
| 123 | Abnormality of proline metabolism (HP:0010907) | 1.74048525 |
| 124 | Hydroxyprolinuria (HP:0003080) | 1.74048525 |
| 125 | Increased serum ferritin (HP:0003281) | 1.73603436 |
| 126 | Alkalosis (HP:0001948) | 1.70975117 |
| 127 | Reticulocytosis (HP:0001923) | 1.69994994 |
| 128 | Hepatoblastoma (HP:0002884) | 1.65066497 |
| 129 | Broad palm (HP:0001169) | 1.64198735 |
| 130 | Hyperphosphaturia (HP:0003109) | 1.62510975 |
| 131 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.56135659 |
| 132 | Mucopolysacchariduria (HP:0008155) | 1.56135659 |
| 133 | Elevated alkaline phosphatase (HP:0003155) | 1.52711763 |
| 134 | Bifid scrotum (HP:0000048) | 1.51326917 |
| 135 | Flared iliac wings (HP:0002869) | 1.51203628 |
| 136 | Abnormality of pain sensation (HP:0010832) | 1.50711370 |
| 137 | Impaired pain sensation (HP:0007328) | 1.50711370 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BCKDK | 7.28992218 |
| 2 | FGFR4 | 4.84574094 |
| 3 | ERN1 | 4.79749979 |
| 4 | SIK1 | 4.32032837 |
| 5 | WNK4 | 3.93625647 |
| 6 | TAOK3 | 3.09469845 |
| 7 | ERBB4 | 3.05695468 |
| 8 | CDK12 | 3.03826924 |
| 9 | INSRR | 2.76882137 |
| 10 | TYRO3 | 2.56431720 |
| 11 | MAP2K4 | 2.31559263 |
| 12 | MST1R | 2.08939676 |
| 13 | FGFR1 | 2.03532859 |
| 14 | MAPK11 | 2.01005715 |
| 15 | PKN2 | 1.95581393 |
| 16 | AKT3 | 1.95411190 |
| 17 | TRIB3 | 1.92795784 |
| 18 | PDGFRA | 1.85217621 |
| 19 | WNK1 | 1.82421097 |
| 20 | PIK3CG | 1.80211202 |
| 21 | TYK2 | 1.78548619 |
| 22 | FLT3 | 1.66116066 |
| 23 | DAPK2 | 1.60558368 |
| 24 | SIK2 | 1.57624734 |
| 25 | PTK6 | 1.55127884 |
| 26 | EIF2AK1 | 1.52192790 |
| 27 | LATS1 | 1.51340612 |
| 28 | ABL2 | 1.49204378 |
| 29 | NEK9 | 1.37424988 |
| 30 | KDR | 1.35846900 |
| 31 | JAK2 | 1.29298760 |
| 32 | FGFR2 | 1.25004973 |
| 33 | FRK | 1.24065926 |
| 34 | DDR2 | 1.19257719 |
| 35 | PINK1 | 1.12616244 |
| 36 | GRK6 | 1.10582407 |
| 37 | MAP3K7 | 1.09516511 |
| 38 | TBK1 | 1.07706741 |
| 39 | MAP2K3 | 1.06498214 |
| 40 | ERBB2 | 1.03900999 |
| 41 | PRKAA2 | 1.03559409 |
| 42 | JAK1 | 1.02738861 |
| 43 | MAPK4 | 1.00515291 |
| 44 | EPHB1 | 0.99726595 |
| 45 | SGK1 | 0.97394497 |
| 46 | EEF2K | 0.97026935 |
| 47 | EPHA3 | 0.95377971 |
| 48 | MAP3K10 | 0.91584043 |
| 49 | PRKCZ | 0.89094341 |
| 50 | FGR | 0.87947347 |
| 51 | MAP3K14 | 0.87522569 |
| 52 | CDK7 | 0.86237500 |
| 53 | MAPK12 | 0.85857372 |
| 54 | MET | 0.84884786 |
| 55 | MAP3K11 | 0.83444096 |
| 56 | MAPK15 | 0.82384057 |
| 57 | CDK6 | 0.81234684 |
| 58 | CSNK1E | 0.80157841 |
| 59 | MAP3K3 | 0.79614650 |
| 60 | TIE1 | 0.79574344 |
| 61 | STK38L | 0.77671779 |
| 62 | PRKACG | 0.77172678 |
| 63 | MAPKAPK3 | 0.76142471 |
| 64 | CAMK2G | 0.74713132 |
| 65 | CDC42BPA | 0.73628869 |
| 66 | RPS6KB1 | 0.71795850 |
| 67 | STK39 | 0.71277754 |
| 68 | DYRK1B | 0.71206565 |
| 69 | NTRK3 | 0.69685761 |
| 70 | CSK | 0.67408981 |
| 71 | NEK1 | 0.67213450 |
| 72 | GSK3A | 0.66348287 |
| 73 | RIPK1 | 0.64345045 |
| 74 | NEK2 | 0.63846010 |
| 75 | MAP2K6 | 0.63440186 |
| 76 | BRSK1 | 0.62892257 |
| 77 | CSNK1D | 0.62450446 |
| 78 | PRKAA1 | 0.61195959 |
| 79 | SGK3 | 0.60680814 |
| 80 | FGFR3 | 0.56648503 |
| 81 | PTK2 | 0.56481625 |
| 82 | BCR | 0.56365643 |
| 83 | TGFBR2 | 0.55589806 |
| 84 | MATK | 0.55210077 |
| 85 | PDPK1 | 0.54296982 |
| 86 | MAPK7 | 0.54140667 |
| 87 | PRKG1 | 0.54125625 |
| 88 | IKBKE | 0.52674175 |
| 89 | IRAK3 | 0.52429149 |
| 90 | CSF1R | 0.51631369 |
| 91 | CSNK2A2 | 0.51053222 |
| 92 | CAMK1D | 0.51015829 |
| 93 | MAP2K1 | 0.47661904 |
| 94 | BRSK2 | 0.47433346 |
| 95 | PRKCQ | 0.47165503 |
| 96 | PKN1 | 0.46218957 |
| 97 | SRC | 0.45748553 |
| 98 | RET | 0.45653868 |
| 99 | EPHA4 | 0.45546402 |
| 100 | TAOK2 | 0.44759398 |
| 101 | EPHA2 | 0.44735509 |
| 102 | RPS6KA3 | 0.43966862 |
| 103 | CSNK1G1 | 0.43562525 |
| 104 | SGK2 | 0.43551295 |
| 105 | PRKCG | 0.43428163 |
| 106 | CSNK2A1 | 0.42449039 |
| 107 | GRK1 | 0.42265346 |
| 108 | MAP3K5 | 0.41351245 |
| 109 | CDK4 | 0.39827708 |
| 110 | IGF1R | 0.39321955 |
| 111 | CDK8 | 0.39221482 |
| 112 | BRD4 | 0.38478655 |
| 113 | MAP3K1 | 0.38328844 |
| 114 | EIF2AK3 | 0.37905095 |
| 115 | MAP3K13 | 0.37219531 |
| 116 | PRKACA | 0.35388623 |
| 117 | ICK | 0.35160857 |
| 118 | EGFR | 0.34292860 |
| 119 | PBK | 0.33198273 |
| 120 | CAMK4 | 0.33030935 |
| 121 | MTOR | 0.32820318 |
| 122 | SGK223 | 0.31951617 |
| 123 | SGK494 | 0.31951617 |
| 124 | MAP3K6 | 0.31747641 |
| 125 | PRKCB | 0.31613067 |
| 126 | MAPK3 | 0.31397858 |
| 127 | MAP2K2 | 0.31347586 |
| 128 | PDK1 | 0.31212305 |
| 129 | MAP3K2 | 0.30004189 |
| 130 | KSR2 | 0.29970841 |
| 131 | LATS2 | 0.28917066 |
| 132 | NTRK2 | 0.28720835 |
| 133 | PRKCA | 0.26234550 |
| 134 | STK16 | 0.25374895 |
| 135 | CAMK1G | 0.25313629 |
| 136 | NLK | 0.23018402 |
| 137 | BMX | 0.22719784 |
| 138 | IRAK1 | 0.22170738 |
| 139 | CSNK1G3 | 0.21944630 |
| 140 | CSNK1G2 | 0.21916317 |
| 141 | PIK3CA | 0.20273313 |
| 142 | ABL1 | 0.19576353 |
| 143 | PRKACB | 0.18848629 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 4.66548226 |
| 2 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.59199169 |
| 3 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.44555172 |
| 4 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 3.22092218 |
| 5 | Arginine biosynthesis_Homo sapiens_hsa00220 | 3.10241043 |
| 6 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 2.99330661 |
| 7 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.68910508 |
| 8 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.66296354 |
| 9 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.65456772 |
| 10 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.57241576 |
| 11 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.47755915 |
| 12 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.35778322 |
| 13 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.14923762 |
| 14 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.14116038 |
| 15 | Peroxisome_Homo sapiens_hsa04146 | 2.09233951 |
| 16 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.04726446 |
| 17 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.89819389 |
| 18 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.89523600 |
| 19 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.88284379 |
| 20 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.87856962 |
| 21 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.87279105 |
| 22 | Histidine metabolism_Homo sapiens_hsa00340 | 1.86419943 |
| 23 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.83996095 |
| 24 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.80230249 |
| 25 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.73424739 |
| 26 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.73400992 |
| 27 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.67463036 |
| 28 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.67243592 |
| 29 | Retinol metabolism_Homo sapiens_hsa00830 | 1.63374838 |
| 30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.62866040 |
| 31 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.61685075 |
| 32 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.56552327 |
| 33 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.55581906 |
| 34 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.54783379 |
| 35 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.51839394 |
| 36 | Bile secretion_Homo sapiens_hsa04976 | 1.48992405 |
| 37 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.45973449 |
| 38 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.34600288 |
| 39 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.34549142 |
| 40 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.33808182 |
| 41 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.31517288 |
| 42 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.24210261 |
| 43 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.23558772 |
| 44 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.22687964 |
| 45 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.18964483 |
| 46 | ABC transporters_Homo sapiens_hsa02010 | 1.17856225 |
| 47 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.14523992 |
| 48 | Carbon metabolism_Homo sapiens_hsa01200 | 1.11180560 |
| 49 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.03792884 |
| 50 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.03641192 |
| 51 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.00814681 |
| 52 | Sulfur relay system_Homo sapiens_hsa04122 | 1.00392603 |
| 53 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.97492439 |
| 54 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.97077907 |
| 55 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.94893788 |
| 56 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.88820299 |
| 57 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.88612649 |
| 58 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.83747773 |
| 59 | Lysine degradation_Homo sapiens_hsa00310 | 0.77992093 |
| 60 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.74430910 |
| 61 | Other glycan degradation_Homo sapiens_hsa00511 | 0.68114007 |
| 62 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.67375764 |
| 63 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.65959397 |
| 64 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.61207703 |
| 65 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.57795786 |
| 66 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.47963877 |
| 67 | Prion diseases_Homo sapiens_hsa05020 | 0.47617502 |
| 68 | Metabolic pathways_Homo sapiens_hsa01100 | 0.46199440 |
| 69 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.43319005 |
| 70 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.42017747 |
| 71 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.32101206 |
| 72 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.26627961 |
| 73 | Galactose metabolism_Homo sapiens_hsa00052 | 0.26312007 |
| 74 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.24161917 |
| 75 | Insulin resistance_Homo sapiens_hsa04931 | 0.23539616 |
| 76 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.22791177 |
| 77 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.21506705 |
| 78 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.19133567 |
| 79 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.17161900 |
| 80 | Mineral absorption_Homo sapiens_hsa04978 | 0.10864044 |
| 81 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.09390098 |
| 82 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.01124856 |
| 83 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.00798446 |
| 84 | Ether lipid metabolism_Homo sapiens_hsa00565 | -0.2394139 |
| 85 | Pertussis_Homo sapiens_hsa05133 | -0.2335261 |
| 86 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | -0.2200668 |
| 87 | Amoebiasis_Homo sapiens_hsa05146 | -0.2110574 |
| 88 | Bladder cancer_Homo sapiens_hsa05219 | -0.2034665 |
| 89 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | -0.1826272 |
| 90 | Renin-angiotensin system_Homo sapiens_hsa04614 | -0.1801469 |
| 91 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | -0.1725396 |
| 92 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | -0.1722973 |
| 93 | Hepatitis C_Homo sapiens_hsa05160 | -0.1624237 |
| 94 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | -0.1588803 |
| 95 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | -0.1541727 |
| 96 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | -0.1528361 |
| 97 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | -0.1432194 |
| 98 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.1237728 |
| 99 | Circadian rhythm_Homo sapiens_hsa04710 | -0.1172470 |
| 100 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | -0.1045645 |
| 101 | Insulin signaling pathway_Homo sapiens_hsa04910 | -0.1032758 |
| 102 | African trypanosomiasis_Homo sapiens_hsa05143 | -0.0925413 |
| 103 | ECM-receptor interaction_Homo sapiens_hsa04512 | -0.0820418 |
| 104 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0780396 |
| 105 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | -0.0604370 |
| 106 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.0573884 |
| 107 | Sphingolipid metabolism_Homo sapiens_hsa00600 | -0.0110628 |
| 108 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | -0.0017854 |

