ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	keratinocyte differentiation (GO:0030216)	8.98422283
2	molting cycle (GO:0042303)	8.64533364
3	hair cycle (GO:0042633)	8.64533364
4	water homeostasis (GO:0030104)	8.43828746
5	epidermal cell differentiation (GO:0009913)	7.33972115
6	L-phenylalanine catabolic process (GO:0006559)	7.11214310
7	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.11214310
8	L-phenylalanine metabolic process (GO:0006558)	6.76809042
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.76809042
10	aromatic amino acid family catabolic process (GO:0009074)	6.48817781
11	intermediate filament organization (GO:0045109)	6.40929827
12	peptide cross-linking (GO:0018149)	6.39627787
13	epidermis development (GO:0008544)	6.37974587
14	tryptophan catabolic process (GO:0006569)	6.07409807
15	indole-containing compound catabolic process (GO:0042436)	6.07409807
16	indolalkylamine catabolic process (GO:0046218)	6.07409807
17	phospholipid efflux (GO:0033700)	5.97210035
18	kynurenine metabolic process (GO:0070189)	5.94128825
19	long-chain fatty acid biosynthetic process (GO:0042759)	5.90327518
20	establishment of skin barrier (GO:0061436)	5.87092897
21	bile acid biosynthetic process (GO:0006699)	5.85964233
22	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.71705881
23	tryptophan metabolic process (GO:0006568)	5.66751138
24	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.63314655
25	high-density lipoprotein particle remodeling (GO:0034375)	5.54498780
26	glyoxylate metabolic process (GO:0046487)	5.50593242
27	complement activation, alternative pathway (GO:0006957)	5.47773731
28	regulation of protein activation cascade (GO:2000257)	5.37641992
29	urea cycle (GO:0000050)	5.35189624
30	urea metabolic process (GO:0019627)	5.35189624
31	negative regulation of fibrinolysis (GO:0051918)	5.14367244
32	alpha-linolenic acid metabolic process (GO:0036109)	5.13876354
33	regulation of fibrinolysis (GO:0051917)	5.10506102
34	regulation of complement activation (GO:0030449)	5.09722577
35	skin morphogenesis (GO:0043589)	5.07010271
36	peptidyl-glutamic acid carboxylation (GO:0017187)	5.05355979
37	protein carboxylation (GO:0018214)	5.05355979
38	sulfur amino acid catabolic process (GO:0000098)	4.97567090
39	imidazole-containing compound metabolic process (GO:0052803)	4.93741184
40	regulation of water loss via skin (GO:0033561)	4.93132936
41	nitrogen cycle metabolic process (GO:0071941)	4.89573869
42	regulation of triglyceride catabolic process (GO:0010896)	4.83277949
43	bile acid metabolic process (GO:0008206)	4.79908189
44	reverse cholesterol transport (GO:0043691)	4.77920727
45	positive regulation of cellular amide metabolic process (GO:0034250)	4.77307293
46	lipoxygenase pathway (GO:0019372)	4.73868312
47	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.71485811
48	phosphatidylserine acyl-chain remodeling (GO:0036150)	4.67431642
49	cysteine metabolic process (GO:0006534)	4.67128476
50	aromatic amino acid family metabolic process (GO:0009072)	4.65014646
51	protein-lipid complex remodeling (GO:0034368)	4.60529211
52	macromolecular complex remodeling (GO:0034367)	4.60529211
53	plasma lipoprotein particle remodeling (GO:0034369)	4.60529211
54	serine family amino acid catabolic process (GO:0009071)	4.60261425
55	triglyceride homeostasis (GO:0070328)	4.55154758
56	acylglycerol homeostasis (GO:0055090)	4.55154758
57	coenzyme catabolic process (GO:0009109)	4.49565955
58	phosphatidylinositol acyl-chain remodeling (GO:0036149)	4.48606712
59	intermediate filament cytoskeleton organization (GO:0045104)	4.45717665
60	keratinocyte development (GO:0003334)	4.35644458
61	regulation of cholesterol esterification (GO:0010872)	4.34733632
62	alpha-amino acid catabolic process (GO:1901606)	4.33820987
63	amino-acid betaine metabolic process (GO:0006577)	4.33048691
64	tyrosine metabolic process (GO:0006570)	4.32866518
65	linoleic acid metabolic process (GO:0043651)	4.30788463
66	intermediate filament-based process (GO:0045103)	4.30300729
67	homocysteine metabolic process (GO:0050667)	4.27701713
68	indolalkylamine metabolic process (GO:0006586)	4.24189274
69	glutamate metabolic process (GO:0006536)	4.22992160
70	bile acid and bile salt transport (GO:0015721)	4.22290057
71	fatty acid elongation (GO:0030497)	4.20569998
72	lysine metabolic process (GO:0006553)	4.18115604
73	lysine catabolic process (GO:0006554)	4.18115604
74	hemidesmosome assembly (GO:0031581)	4.15295376
75	cytolysis (GO:0019835)	4.14748867
76	negative regulation of sterol transport (GO:0032372)	4.14515672
77	negative regulation of cholesterol transport (GO:0032375)	4.14515672
78	cholesterol efflux (GO:0033344)	4.12327084
79	fibrinolysis (GO:0042730)	4.11201837
80	cellular biogenic amine catabolic process (GO:0042402)	4.11191012
81	amine catabolic process (GO:0009310)	4.11191012
82	cellular ketone body metabolic process (GO:0046950)	4.07588491
83	plasma lipoprotein particle clearance (GO:0034381)	4.06011930
84	glycine metabolic process (GO:0006544)	4.05218057
85	cellular amino acid catabolic process (GO:0009063)	4.00185301
86	cellular glucuronidation (GO:0052695)	3.93795968
87	cellular modified amino acid catabolic process (GO:0042219)	3.92338289
88	ethanol oxidation (GO:0006069)	3.89729733
89	benzene-containing compound metabolic process (GO:0042537)	3.88925742
90	complement activation, classical pathway (GO:0006958)	3.84728824
91	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.83755722
92	complement activation (GO:0006956)	3.78732594
93	arginine metabolic process (GO:0006525)	3.77341010
94	serine family amino acid metabolic process (GO:0009069)	3.76895171
95	dicarboxylic acid biosynthetic process (GO:0043650)	3.74880872
96	regulation of cholesterol homeostasis (GO:2000188)	3.69040997
97	protein activation cascade (GO:0072376)	3.68960727
98	very long-chain fatty acid metabolic process (GO:0000038)	3.67484165
99	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.67477309
100	cofactor catabolic process (GO:0051187)	3.66502476
101	polarized epithelial cell differentiation (GO:0030859)	3.65754606
102	positive regulation of glomerulus development (GO:0090193)	3.65456347
103	positive regulation of triglyceride lipase activity (GO:0061365)	3.64078945
104	positive regulation of lipoprotein lipase activity (GO:0051006)	3.64078945
105	negative regulation of lipase activity (GO:0060192)	3.63003539
106	regulation of cell proliferation involved in kidney development (GO:1901722)	3.60993649
107	blood coagulation, intrinsic pathway (GO:0007597)	3.60899997
108	regulation of keratinocyte differentiation (GO:0045616)	3.60173235
109	acetyl-CoA metabolic process (GO:0006084)	3.57489413
110	plasma lipoprotein particle assembly (GO:0034377)	3.56148741
111	epithelial cell differentiation involved in prostate gland development (GO:0060742)	3.51825792
112	aldehyde catabolic process (GO:0046185)	3.51819571
113	ketone body metabolic process (GO:1902224)	3.51048062
114	glucuronate metabolic process (GO:0019585)	3.50784175
115	uronic acid metabolic process (GO:0006063)	3.50784175
116	positive regulation of lipid catabolic process (GO:0050996)	3.49672308
117	serine family amino acid biosynthetic process (GO:0009070)	3.48693449
118	regulation of transforming growth factor beta1 production (GO:0032908)	3.48018682
119	keratinization (GO:0031424)	3.46479765
120	organic acid catabolic process (GO:0016054)	3.44962625
121	carboxylic acid catabolic process (GO:0046395)	3.44962625
122	plasma lipoprotein particle organization (GO:0071827)	3.43553939
123	cholesterol homeostasis (GO:0042632)	3.43018997
124	low-density lipoprotein particle remodeling (GO:0034374)	3.42753616
125	phospholipid homeostasis (GO:0055091)	3.41197825
126	positive regulation of interleukin-8 secretion (GO:2000484)	3.40202199
127	regulation of bile acid biosynthetic process (GO:0070857)	3.38308267
128	hair follicle morphogenesis (GO:0031069)	3.37995878
129	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.34021010
130	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	3.24904598
131	retinol metabolic process (GO:0042572)	3.23205366
132	defense response to fungus (GO:0050832)	3.22227321
133	gap junction assembly (GO:0016264)	3.19803407
134	surfactant homeostasis (GO:0043129)	3.18825123
135	positive regulation of transforming growth factor beta production (GO:0071636)	3.18450290
136	lateral sprouting from an epithelium (GO:0060601)	3.17876270
137	establishment of tissue polarity (GO:0007164)	3.16780741
138	establishment of planar polarity (GO:0001736)	3.16780741
139	positive regulation of humoral immune response (GO:0002922)	3.14498784
140	epithelium development (GO:0060429)	3.14002967
141	detection of bacterium (GO:0016045)	3.11004946
142	positive regulation of epidermal cell differentiation (GO:0045606)	3.04353549
143	positive regulation of p38MAPK cascade (GO:1900745)	3.00080683
144	phospholipid catabolic process (GO:0009395)	2.99706901
145	ectoderm development (GO:0007398)	2.97861224
146	ceramide biosynthetic process (GO:0046513)	2.97408938
147	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	2.95541939
148	positive regulation of keratinocyte differentiation (GO:0045618)	2.95063593
149	positive regulation of cholesterol efflux (GO:0010875)	2.93290627
150	positive regulation of chemokine secretion (GO:0090197)	2.93061123
151	chemical homeostasis within a tissue (GO:0048875)	2.92207705
152	phosphatidylserine metabolic process (GO:0006658)	2.91518096
153	polyol transport (GO:0015791)	2.87155002
154	regulation of chemokine secretion (GO:0090196)	2.85068813
155	positive regulation of epidermis development (GO:0045684)	2.81280274
156	fatty-acyl-CoA biosynthetic process (GO:0046949)	2.79956253
157	response to phenylpropanoid (GO:0080184)	2.79309526
158	negative regulation of interferon-gamma production (GO:0032689)	2.79001807
159	detection of other organism (GO:0098543)	2.73657666
160	defense response to Gram-negative bacterium (GO:0050829)	2.68054060
161	regulation of epidermis development (GO:0045682)	2.67117675
162	regulation of epidermal cell differentiation (GO:0045604)	2.66589520
163	epithelial cell proliferation (GO:0050673)	2.65411618
164	very-low-density lipoprotein particle assembly (GO:0034379)	2.62639274
165	primary alcohol metabolic process (GO:0034308)	2.59434926
166	positive regulation of cholesterol transport (GO:0032376)	2.57344176
167	positive regulation of sterol transport (GO:0032373)	2.57344176
168	hair cycle process (GO:0022405)	2.55667430
169	molting cycle process (GO:0022404)	2.55667430
170	negative regulation of keratinocyte proliferation (GO:0010839)	2.55228169
171	lung epithelium development (GO:0060428)	2.54866492
172	regulation of cellular amide metabolic process (GO:0034248)	2.51248701
173	regulation of axon regeneration (GO:0048679)	2.51112412
174	regulation of neuron projection regeneration (GO:0070570)	2.51112412
175	positive regulation of collagen biosynthetic process (GO:0032967)	2.50028863
176	low-density lipoprotein particle clearance (GO:0034383)	2.45635647
177	regulation of glomerulus development (GO:0090192)	2.44228195
178	alditol phosphate metabolic process (GO:0052646)	2.42029849
179	negative regulation of cardiac muscle tissue growth (GO:0055022)	2.40125997
180	negative regulation of heart growth (GO:0061117)	2.40125997
181	desmosome organization (GO:0002934)	13.3476362
182	keratinocyte proliferation (GO:0043616)	10.3172759
183	multicellular organismal water homeostasis (GO:0050891)	10.0847780

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.31378666
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.41754534
3	* EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.37495982
4	* LXR_22158963_ChIP-Seq_LIVER_Mouse	5.74900011
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.73542839
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.35565878
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.10606244
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.74851215
9	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.35203245
10	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.95881452
11	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.78691927
12	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.53343786
13	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.52766006
14	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.34445023
15	RXR_22108803_ChIP-Seq_LS180_Human	2.12420329
16	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.03527022
17	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.03527022
18	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.03473515
19	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	10.5223813
20	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.80030161
21	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.77729395
22	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.76647711
23	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.71126947
24	HTT_18923047_ChIP-ChIP_STHdh_Human	1.67726559
25	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.66408109
26	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.65880495
27	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.50064205
28	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.48603345
29	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.48151772
30	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.41797746
31	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.40386408
32	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.37627446
33	CLOCK_20551151_ChIP-Seq_293T_Human	1.34849860
34	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.34648271
35	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.30899917
36	AR_21572438_ChIP-Seq_LNCaP_Human	1.22574882
37	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.18376619
38	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.16960790
39	GATA4_25053715_ChIP-Seq_YYC3_Human	1.15574496
40	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.12976683
41	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.12258957
42	* UBF1/2_26484160_Chip-Seq_HMECs_Human	1.11901456
43	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.11540483
44	ATF3_27146783_Chip-Seq_COLON_Human	1.11439526
45	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.10313166
46	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.09865366
47	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.08690546
48	KLF5_25053715_ChIP-Seq_YYC3_Human	1.08677815
49	GATA1_22025678_ChIP-Seq_K562_Human	1.07919941
50	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.05569580
51	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.04143832
52	RACK7_27058665_Chip-Seq_MCF-7_Human	1.02047830
53	CEBPB_22108803_ChIP-Seq_LS180_Human	1.00784077
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00508977
55	TP53_16413492_ChIP-PET_HCT116_Human	0.99118294
56	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.98043185
57	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.97811803
58	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.95136374
59	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.94126926
60	* SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.93561398
61	TAF15_26573619_Chip-Seq_HEK293_Human	0.89178054
62	AHR_22903824_ChIP-Seq_MCF-7_Human	0.88483254
63	CJUN_26792858_Chip-Seq_BT549_Human	0.87232713
64	SOX2_20726797_ChIP-Seq_SW620_Human	0.86670691
65	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.86269943
66	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.86211371
67	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.85565716
68	ZNF263_19887448_ChIP-Seq_K562_Human	0.85282861
69	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.83675790
70	TP63_23658742_ChIP-Seq_EP156T_Human	0.81750907
71	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.81269940
72	CTCF_20526341_ChIP-Seq_ESCs_Human	0.81175372
73	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.81042676
74	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.80788177
75	SMC4_20622854_ChIP-Seq_HELA_Human	0.79823835
76	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.79447884
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.78275667
78	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.77858210
79	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.76422924
80	LXR_22292898_ChIP-Seq_THP-1_Human	0.76413238
81	BCAT_22108803_ChIP-Seq_LS180_Human	0.76335396
82	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.75858322
83	ERG_20517297_ChIP-Seq_VCAP_Human	0.75796237
84	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.75670044
85	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.74559923
86	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.74159443
87	BCOR_27268052_Chip-Seq_Bcells_Human	0.73350480
88	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.73298654
89	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.73129732
90	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.71256669
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.70791321
92	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.70490555
93	* NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.70337504
94	* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.70337504
95	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.70027070
96	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.69591704
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.68705035
98	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.68090440
99	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.67980473
100	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.67266127
101	SMAD4_21741376_ChIP-Seq_ESCs_Human	0.65941800
102	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.65807334
103	CDX2_22108803_ChIP-Seq_LS180_Human	0.65416740
104	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.64030390
105	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.62883177
106	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.62667438
107	E2F1_20622854_ChIP-Seq_HELA_Human	0.62370899
108	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.62359418
109	MYC_19915707_ChIP-ChIP_AK7_Human	0.62294168
110	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.61748287
111	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.61503118
112	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.61251704
113	CBP_21632823_ChIP-Seq_H3396_Human	0.57216842
114	CTCF_27219007_Chip-Seq_Bcells_Human	0.57004209
115	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.56692189
116	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.56627190
117	EGR1_19032775_ChIP-ChIP_M12_Human	0.55354733
118	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.55269203
119	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.54720596
120	TP53_18474530_ChIP-ChIP_U2OS_Human	0.54538383
121	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.54519639
122	TP63_22573176_ChIP-Seq_HFKS_Human	0.54102539
123	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.54079486
124	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.53639603
125	GATA6_25053715_ChIP-Seq_YYC3_Human	0.53034497
126	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.52850432
127	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.52757582
128	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.51332742
129	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.51321226
130	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.51204435
131	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.51093086
132	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.49866007
133	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.49131706
134	ERA_21632823_ChIP-Seq_H3396_Human	0.49125530
135	AR_20517297_ChIP-Seq_VCAP_Human	0.49075635
136	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.49018849
137	GATA2_19941826_ChIP-Seq_K562_Human	0.48924982
138	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.48916966
139	* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.48617482
140	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.47812477
141	* STAT1_17558387_ChIP-Seq_HELA_Human	0.47103293
142	TCF4_22108803_ChIP-Seq_LS180_Human	0.46529833
143	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.46430370

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.00206436
2	MP0005360_urolithiasis	6.34564677
3	MP0005085_abnormal_gallbladder_physiolo	5.49531686
4	MP0005365_abnormal_bile_salt	5.17255015
5	MP0002796_impaired_skin_barrier	4.50954298
6	MP0005451_abnormal_body_composition	3.96960505
7	MP0010234_abnormal_vibrissa_follicle	3.93160046
8	MP0008875_abnormal_xenobiotic_pharmacok	3.84802285
9	MP0003191_abnormal_cellular_cholesterol	3.71842959
10	MP0003806_abnormal_nucleotide_metabolis	3.53141983
11	MP0003252_abnormal_bile_duct	3.50775611
12	MP0000566_synostosis	3.18816585
13	MP0001188_hyperpigmentation	2.99128398
14	MP0010329_abnormal_lipoprotein_level	2.99003095
15	MP0005275_abnormal_skin_tensile	2.64563661
16	MP0009840_abnormal_foam_cell	2.53726233
17	MP0005501_abnormal_skin_physiology	2.50748739
18	MP0003941_abnormal_skin_development	2.48577766
19	MP0003195_calcinosis	2.45865369
20	MP0000015_abnormal_ear_pigmentation	2.35363636
21	MP0005083_abnormal_biliary_tract	2.25483297
22	MP0001666_abnormal_nutrient_absorption	2.24652080
23	MP0004381_abnormal_hair_follicle	2.22691664
24	MP0005174_abnormal_tail_pigmentation	2.18669082
25	MP0005332_abnormal_amino_acid	2.16058963
26	MP0002095_abnormal_skin_pigmentation	2.11358079
27	MP0004019_abnormal_vitamin_homeostasis	1.82078641
28	MP0002118_abnormal_lipid_homeostasis	1.81998732
29	MP0005409_darkened_coat_color	1.80205081
30	MP0000609_abnormal_liver_physiology	1.78671152
31	MP0002060_abnormal_skin_morphology	1.67839653
32	MP0002254_reproductive_system_inflammat	1.66314066
33	MP0004947_skin_inflammation	1.66125547
34	MP0002138_abnormal_hepatobiliary_system	1.47554789
35	MP0003868_abnormal_feces_composition	1.43862067
36	MP0005319_abnormal_enzyme/_coenzyme	1.41812676
37	MP0001216_abnormal_epidermal_layer	1.38117982
38	MP0004782_abnormal_surfactant_physiolog	1.36904656
39	MP0010771_integument_phenotype	1.34656529
40	MP0003705_abnormal_hypodermis_morpholog	1.34150799
41	MP0010678_abnormal_skin_adnexa	1.30075664
42	MP0000647_abnormal_sebaceous_gland	1.20710987
43	MP0001764_abnormal_homeostasis	1.17227163
44	MP0005647_abnormal_sex_gland	1.16674638
45	MP0000579_abnormal_nail_morphology	1.14142041
46	MP0003011_delayed_dark_adaptation	1.14109832
47	MP0005584_abnormal_enzyme/coenzyme_acti	1.10753797
48	MP0009697_abnormal_copulation	1.06556343
49	MP0009780_abnormal_chondrocyte_physiolo	1.04329626
50	MP0003566_abnormal_cell_adhesion	1.02644140
51	MP0002098_abnormal_vibrissa_morphology	1.00997371
52	MP0003950_abnormal_plasma_membrane	0.98913834
53	MP0002876_abnormal_thyroid_physiology	0.98881289
54	MP0000604_amyloidosis	0.96171155
55	MP0003453_abnormal_keratinocyte_physiol	0.95962390
56	MP0002177_abnormal_outer_ear	0.94467641
57	MP0000427_abnormal_hair_cycle	0.93377475
58	MP0009643_abnormal_urine_homeostasis	0.90720114
59	MP0009764_decreased_sensitivity_to	0.90300092
60	MP0000377_abnormal_hair_follicle	0.89891439
61	MP0001984_abnormal_olfaction	0.88564150
62	MP0009931_abnormal_skin_appearance	0.87994310
63	MP0010368_abnormal_lymphatic_system	0.85579200
64	MP0004185_abnormal_adipocyte_glucose	0.85542892
65	MP0000762_abnormal_tongue_morphology	0.80569022
66	MP0009379_abnormal_foot_pigmentation	0.79956396
67	MP0003656_abnormal_erythrocyte_physiolo	0.79276788
68	MP0000598_abnormal_liver_morphology	0.78047972
69	MP0003329_amyloid_beta_deposits	0.77427117
70	MP0003186_abnormal_redox_activity	0.77263528
71	MP0001191_abnormal_skin_condition	0.75464994
72	MP0005670_abnormal_white_adipose	0.72337691
73	MP0009763_increased_sensitivity_to	0.72202395
74	MP0005636_abnormal_mineral_homeostasis	0.70456658
75	MP0001784_abnormal_fluid_regulation	0.68110243
76	MP0002009_preneoplasia	0.67816508
77	MP0008469_abnormal_protein_level	0.67319434
78	MP0001851_eye_inflammation	0.65176004
79	MP0009765_abnormal_xenobiotic_induced	0.63449822
80	MP0002971_abnormal_brown_adipose	0.63139245
81	MP0009642_abnormal_blood_homeostasis	0.62811536
82	MP0001243_abnormal_dermal_layer	0.62437186
83	MP0005408_hypopigmentation	0.61792079
84	MP0009384_cardiac_valve_regurgitation	0.60822032
85	MP0005023_abnormal_wound_healing	0.59117745
86	MP0000465_gastrointestinal_hemorrhage	0.58135828
87	MP0005220_abnormal_exocrine_pancreas	0.57179596
88	MP0010030_abnormal_orbit_morphology	0.55595368
89	MP0000383_abnormal_hair_follicle	0.55404771
90	MP0005257_abnormal_intraocular_pressure	0.55150049
91	MP0002822_catalepsy	0.54989920
92	MP0003878_abnormal_ear_physiology	0.54541234
93	MP0005377_hearing/vestibular/ear_phenot	0.54541234
94	MP0005666_abnormal_adipose_tissue	0.54311891
95	MP0000367_abnormal_coat/_hair	0.52977977
96	MP0005334_abnormal_fat_pad	0.52808935
97	MP0004130_abnormal_muscle_cell	0.52440820
98	MP0001340_abnormal_eyelid_morphology	0.51034478
99	MP0002078_abnormal_glucose_homeostasis	0.50918177
100	MP0009672_abnormal_birth_weight	0.49885337
101	MP0009053_abnormal_anal_canal	0.49594674
102	MP0005376_homeostasis/metabolism_phenot	0.49357539
103	MP0005535_abnormal_body_temperature	0.48494993
104	MP0000467_abnormal_esophagus_morphology	0.47706250
105	MP0003638_abnormal_response/metabolism_	0.46328713
106	MP0005187_abnormal_penis_morphology	0.44602089
107	MP0005075_abnormal_melanosome_morpholog	0.44039096
108	MP0003690_abnormal_glial_cell	0.44022121
109	MP0002089_abnormal_postnatal_growth/wei	0.43100003
110	MP0009333_abnormal_splenocyte_physiolog	0.42842921
111	MP0006036_abnormal_mitochondrial_physio	0.41895977
112	MP0004264_abnormal_extraembryonic_tissu	0.40791116
113	MP0005076_abnormal_cell_differentiation	0.39572067
114	MP0004272_abnormal_basement_membrane	0.39474766
115	MP0002090_abnormal_vision	0.39461873
116	MP0002132_abnormal_respiratory_system	0.39228987
117	MP0005266_abnormal_metabolism	0.39085152
118	MP0005171_absent_coat_pigmentation	0.37869256
119	MP0001186_pigmentation_phenotype	0.37207598
120	MP0005448_abnormal_energy_balance	0.37011287
121	MP0008961_abnormal_basal_metabolism	0.36572355
122	MP0001177_atelectasis	0.35780291
123	MP0003718_maternal_effect	0.35225866
124	MP0002233_abnormal_nose_morphology	0.35181023
125	MP0005084_abnormal_gallbladder_morpholo	0.34480091
126	MP0008873_increased_physiological_sensi	0.34112486
127	MP0003075_altered_response_to	0.31793372
128	MP0001756_abnormal_urination	0.31250815
129	MP0002111_abnormal_tail_morphology	0.31192445
130	MP0002282_abnormal_trachea_morphology	0.31177074
131	MP0000372_irregular_coat_pigmentation	0.31134224
132	MP0008874_decreased_physiological_sensi	0.31091128
133	MP0005166_decreased_susceptibility_to	0.29506184
134	MP0000428_abnormal_craniofacial_morphol	0.29012321
135	MP0003122_maternal_imprinting	0.27837656
136	MP0002166_altered_tumor_susceptibility	0.27372265
137	MP0000627_abnormal_mammary_gland	0.27285372
138	MP0004885_abnormal_endolymph	0.26911807
139	MP0001299_abnormal_eye_distance/	0.25713180
140	MP0003763_abnormal_thymus_physiology	0.25350997
141	MP0002092_abnormal_eye_morphology	0.25310403
142	MP0003315_abnormal_perineum_morphology	0.24068452
143	MP0003567_abnormal_fetal_cardiomyocyte	0.23238521
144	MP0008438_abnormal_cutaneous_collagen	0.22596296
145	MP0005197_abnormal_uvea_morphology	0.22141445
146	MP0002697_abnormal_eye_size	0.21144041
147	MP0000371_diluted_coat_color	0.20908191
148	MP0002234_abnormal_pharynx_morphology	0.19146084
149	MP0002006_tumorigenesis	0.18922102
150	MP0000462_abnormal_digestive_system	0.18131794
151	MP0001853_heart_inflammation	0.16807487
152	MP0008789_abnormal_olfactory_epithelium	0.16071561
153	MP0003755_abnormal_palate_morphology	0.15519080
154	MP0002877_abnormal_melanocyte_morpholog	0.15412666
155	MP0000685_abnormal_immune_system	0.15246587

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Palmoplantar hyperkeratosis (HP:0000972)	8.17733189
2	Palmar hyperkeratosis (HP:0010765)	7.79306858
3	Intrahepatic cholestasis (HP:0001406)	7.17917791
4	Erythema (HP:0010783)	7.17783597
5	Deep venous thrombosis (HP:0002625)	6.81591211
6	Plantar hyperkeratosis (HP:0007556)	6.69297428
7	Conjunctival hamartoma (HP:0100780)	6.56103402
8	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.51684447
9	Prolonged partial thromboplastin time (HP:0003645)	6.15120265
10	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.09321299
11	Hypobetalipoproteinemia (HP:0003563)	5.90201223
12	Complement deficiency (HP:0004431)	5.87693862
13	Xanthomatosis (HP:0000991)	5.87356247
14	Thick nail (HP:0001805)	5.28259902
15	Abnormality of secondary sexual hair (HP:0009888)	5.02137582
16	Abnormality of the axillary hair (HP:0100134)	5.02137582
17	Hyperlipoproteinemia (HP:0010980)	4.93255344
18	Woolly hair (HP:0002224)	4.90263685
19	Congenital ichthyosiform erythroderma (HP:0007431)	4.80641728
20	Fragile nails (HP:0001808)	4.67628360
21	Abnormality of complement system (HP:0005339)	4.57988072
22	Alopecia of scalp (HP:0002293)	4.53251650
23	Hypolipoproteinemia (HP:0010981)	4.39350410
24	Onycholysis (HP:0001806)	4.39076108
25	Hamartoma of the eye (HP:0010568)	4.37154172
26	Epidermoid cyst (HP:0200040)	4.26621652
27	Palmoplantar keratoderma (HP:0000982)	4.26537094
28	Joint hemorrhage (HP:0005261)	4.23514894
29	Fat malabsorption (HP:0002630)	4.13070166
30	Abnormality of the common coagulation pathway (HP:0010990)	4.07292712
31	Hyperammonemia (HP:0001987)	4.00269453
32	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.94722989
33	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.93908787
34	Increased IgE level (HP:0003212)	3.92820472
35	Hyperglycinemia (HP:0002154)	3.82903212
36	Abnormal blistering of the skin (HP:0008066)	3.81443436
37	Hypoalphalipoproteinemia (HP:0003233)	3.81106091
38	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.78513101
39	Ketosis (HP:0001946)	3.68070045
40	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.64892781
41	Eczematoid dermatitis (HP:0000976)	3.62544427
42	Conjugated hyperbilirubinemia (HP:0002908)	3.52319341
43	Abnormality of methionine metabolism (HP:0010901)	3.51462671
44	Abnormality of the intrinsic pathway (HP:0010989)	3.47023176
45	Abnormality of aspartate family amino acid metabolism (HP:0010899)	3.46844362
46	Hyperglycinuria (HP:0003108)	3.44366579
47	Hypoglycemic coma (HP:0001325)	3.42721946
48	Gangrene (HP:0100758)	3.39909278
49	Abnormality of serine family amino acid metabolism (HP:0010894)	3.39834956
50	Abnormality of glycine metabolism (HP:0010895)	3.39834956
51	Steatorrhea (HP:0002570)	3.27933613
52	Hypohidrosis (HP:0000966)	3.23241200
53	Sparse scalp hair (HP:0002209)	3.16915721
54	Aplasia involving bones of the upper limbs (HP:0009823)	3.13915654
55	Aplasia of the phalanges of the hand (HP:0009802)	3.13915654
56	Aplasia involving bones of the extremities (HP:0009825)	3.13915654
57	Hypercholesterolemia (HP:0003124)	3.12122306
58	Abnormality of pyrimidine metabolism (HP:0004353)	3.11906049
59	Abnormality of the salivary glands (HP:0010286)	3.11528636
60	Systemic lupus erythematosus (HP:0002725)	3.03184454
61	Abnormality of fatty-acid metabolism (HP:0004359)	3.01956131
62	Erythroderma (HP:0001019)	3.00579007
63	Pili torti (HP:0003777)	2.98106036
64	Lip pit (HP:0100267)	2.96603017
65	Abnormal hair laboratory examination (HP:0003328)	2.93155605
66	Abnormality of nail color (HP:0100643)	2.89546230
67	Hyperbilirubinemia (HP:0002904)	2.86980070
68	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.85424161
69	Hypochromic microcytic anemia (HP:0004840)	2.84028442
70	Nail dystrophy (HP:0008404)	2.78344825
71	Absent eyelashes (HP:0000561)	2.76488542
72	Myocardial infarction (HP:0001658)	2.75759139
73	Sparse eyelashes (HP:0000653)	2.72050563
74	Vascular calcification (HP:0004934)	2.70285217
75	Delayed CNS myelination (HP:0002188)	2.68437967
76	Abnormality of nucleobase metabolism (HP:0010932)	2.67898640
77	Recurrent gram-negative bacterial infections (HP:0005420)	2.67460294
78	Nasolacrimal duct obstruction (HP:0000579)	2.66528357
79	Oral leukoplakia (HP:0002745)	2.63221166
80	Ketoacidosis (HP:0001993)	2.60207356
81	Spontaneous abortion (HP:0005268)	2.59990469
82	Cholecystitis (HP:0001082)	2.59465875
83	Abnormal gallbladder physiology (HP:0012438)	2.59465875
84	Natal tooth (HP:0000695)	2.51909118
85	Hamartoma (HP:0010566)	2.51516826
86	Hepatocellular carcinoma (HP:0001402)	2.50560692
87	Conical tooth (HP:0000698)	2.50414891
88	Pruritus (HP:0000989)	2.48862572
89	Melanocytic nevus (HP:0000995)	2.48654091
90	Amyloidosis (HP:0011034)	2.47999410
91	Abnormality of permanent molar morphology (HP:0011071)	2.47973642
92	Abnormality of the dental root (HP:0006486)	2.47973642
93	Taurodontia (HP:0000679)	2.47973642
94	Abnormality of purine metabolism (HP:0004352)	2.45894935
95	Dry hair (HP:0011359)	2.45682024
96	Abnormality of serum amino acid levels (HP:0003112)	2.44907084
97	Cardiovascular calcification (HP:0011915)	2.41009476
98	Hypergammaglobulinemia (HP:0010702)	2.40012054
99	Advanced eruption of teeth (HP:0006288)	2.39192428
100	Neonatal onset (HP:0003623)	2.39146178
101	Hyperhidrosis (HP:0000975)	2.36541038
102	Skin nodule (HP:0200036)	2.34898301
103	Metabolic acidosis (HP:0001942)	2.34194171
104	Mitral stenosis (HP:0001718)	2.33410135
105	Abnormality of molar morphology (HP:0011070)	2.30701661
106	Abnormality of molar (HP:0011077)	2.30701661
107	Abnormality of the lacrimal duct (HP:0011481)	2.29217339
108	Dicarboxylic aciduria (HP:0003215)	2.25821156
109	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.25821156
110	Malnutrition (HP:0004395)	2.24429793
111	Abnormal gallbladder morphology (HP:0012437)	2.23678635
112	Corneal erosion (HP:0200020)	2.23346808
113	Hypophosphatemic rickets (HP:0004912)	2.22270764
114	Neonatal death (HP:0003811)	2.21423632
115	Abnormality of the dental pulp (HP:0006479)	2.21277828
116	Xerostomia (HP:0000217)	2.21117208
117	Parakeratosis (HP:0001036)	2.20930654
118	Ectropion (HP:0000656)	2.20576111
119	Follicular hyperkeratosis (HP:0007502)	2.20388340
120	Cholelithiasis (HP:0001081)	2.19410446
121	Selective tooth agenesis (HP:0001592)	2.18873381
122	Spastic diplegia (HP:0001264)	2.18570555
123	Hypotrichosis (HP:0001006)	2.17965401
124	Lethargy (HP:0001254)	2.17605959
125	Right ventricular cardiomyopathy (HP:0011663)	2.17089112
126	Rickets (HP:0002748)	2.16231702
127	Gout (HP:0001997)	2.13434409
128	Hypoglycemic seizures (HP:0002173)	2.11946859
129	Brushfield spots (HP:0001088)	2.10262407
130	Abnormality of hair growth rate (HP:0011363)	2.07953183
131	Slow-growing hair (HP:0002217)	2.07953183
132	Cerebral edema (HP:0002181)	2.07228530
133	Acanthocytosis (HP:0001927)	2.06880920
134	Milia (HP:0001056)	2.05871415
135	Irritability (HP:0000737)	2.05531080
136	Split foot (HP:0001839)	2.03784973
137	Late onset (HP:0003584)	2.01726464
138	Hypoplastic labia majora (HP:0000059)	2.00139167
139	Abnormality of the nasolacrimal system (HP:0000614)	1.99660155
140	Septate vagina (HP:0001153)	1.98616039
141	Absent hair (HP:0002298)	1.98173932
142	Sensorimotor neuropathy (HP:0007141)	1.97191803
143	Gingival bleeding (HP:0000225)	1.96959810
144	Lack of skin elasticity (HP:0100679)	1.95765587
145	Blepharitis (HP:0000498)	1.95620892
146	Abnormality of the gallbladder (HP:0005264)	1.95037318
147	Hydroxyprolinuria (HP:0003080)	1.93762648
148	Abnormality of proline metabolism (HP:0010907)	1.93762648
149	Abnormality of the Achilles tendon (HP:0005109)	1.90345544
150	Pancreatitis (HP:0001733)	1.87159518
151	Glomerulonephritis (HP:0000099)	1.86582997
152	Menorrhagia (HP:0000132)	1.85612261
153	Oligodontia (HP:0000677)	1.85486169
154	Curly hair (HP:0002212)	1.85160571
155	Opisthotonus (HP:0002179)	1.83604210
156	Broad alveolar ridges (HP:0000187)	1.83243252
157	Hyperinsulinemic hypoglycemia (HP:0000825)	1.82338188
158	Ridged nail (HP:0001807)	1.81367204
159	Abnormality of the labia majora (HP:0012881)	1.80528013
160	Abnormal cartilage morphology (HP:0002763)	1.79968729
161	Acanthosis nigricans (HP:0000956)	1.78984922
162	Duplicated collecting system (HP:0000081)	1.78534159
163	Dehydration (HP:0001944)	1.78381343
164	Brittle hair (HP:0002299)	1.76196307
165	Neonatal short-limb short stature (HP:0008921)	1.74676081
166	Skin ulcer (HP:0200042)	1.71927825
167	Alacrima (HP:0000522)	1.71066401
168	Laryngomalacia (HP:0001601)	1.69936200
169	Dry skin (HP:0000958)	1.65651461
170	Pustule (HP:0200039)	1.64471915
171	Abnormality of the alveolar ridges (HP:0006477)	1.57563451
172	Depressed nasal tip (HP:0000437)	1.57426451
173	Anonychia (HP:0001798)	1.52120565
174	Coarse hair (HP:0002208)	1.51666377
175	Abnormality of the renal collecting system (HP:0004742)	1.47886391
176	Seborrheic dermatitis (HP:0001051)	1.43847676
177	Ventricular tachycardia (HP:0004756)	1.43016904
178	Abnormality of incisor morphology (HP:0011063)	1.41983818
179	Hypoplasia of dental enamel (HP:0006297)	1.40886559
180	Coronal craniosynostosis (HP:0004440)	1.40608804
181	Recurrent corneal erosions (HP:0000495)	1.40605181

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	5.73952786
2	STK24	5.60324249
3	EPHA2	5.12977349
4	EEF2K	5.12838428
5	ERN1	4.58184689
6	FGFR4	4.15399710
7	SIK1	4.09085181
8	ERBB4	3.48065442
9	MST1R	3.39667809
10	TGFBR1	3.13322503
11	MAP2K4	2.60781038
12	TAOK3	2.32083907
13	PIK3CG	2.29164377
14	INSRR	2.27403827
15	MAP3K2	2.16312729
16	LATS1	2.05136210
17	TRPM7	1.82740847
18	MAPKAPK3	1.79201648
19	MAP3K3	1.73437036
20	MAPK11	1.66633768
21	MAPKAPK5	1.64853983
22	MAP3K7	1.64145291
23	ICK	1.64060580
24	PTK6	1.56821941
25	FGFR2	1.54619216
26	SGK223	1.50069090
27	SGK494	1.50069090
28	TYK2	1.47705188
29	RPS6KB2	1.43365017
30	FGFR1	1.38144725
31	MAP3K11	1.37313810
32	TRIB3	1.32843096
33	DYRK1B	1.32653321
34	MAP3K14	1.31200130
35	AKT3	1.30579906
36	STK38L	1.25578660
37	WNK1	1.23186129
38	CDK12	1.20875204
39	JAK2	1.17600229
40	ABL2	1.13042612
41	MAP3K10	1.11229746
42	PKN2	1.10096682
43	ERBB2	1.05644804
44	NEK9	1.05389820
45	RPS6KB1	1.04074672
46	PRKAA2	1.03966347
47	TBK1	1.02364827
48	SGK2	1.01118647
49	PINK1	0.96977515
50	MET	0.94805267
51	MAP2K3	0.94001759
52	JAK1	0.93145377
53	FRK	0.92685974
54	CDK6	0.89897723
55	MAPK4	0.89752641
56	RIPK1	0.89178307
57	LATS2	0.88794299
58	PKN1	0.86614540
59	PRPF4B	0.85595644
60	FLT3	0.84598668
61	ITK	0.83573721
62	DAPK2	0.83456453
63	SGK3	0.80956701
64	EPHB1	0.77895637
65	PAK3	0.75932248
66	MAPK15	0.73138972
67	PRKCZ	0.72790530
68	EPHA3	0.71684793
69	MAP2K6	0.70490644
70	IRAK1	0.70311664
71	MAPK12	0.69827950
72	MTOR	0.69289321
73	GRK5	0.69179945
74	NLK	0.68853233
75	GRK6	0.68601838
76	PRKACG	0.67221463
77	MAP2K1	0.65853358
78	FER	0.65574969
79	MAP3K5	0.64001248
80	PIK3CA	0.59338565
81	SYK	0.58886546
82	FGFR3	0.57526471
83	MAPKAPK2	0.57348084
84	EPHA4	0.56938815
85	TGFBR2	0.56484532
86	CAMK2G	0.56169039
87	MAP3K9	0.55734909
88	IKBKE	0.55716050
89	SGK1	0.55591446
90	GSK3A	0.54823590
91	KDR	0.54456827
92	GRK7	0.53854451
93	MAP3K1	0.53544483
94	MOS	0.53477712
95	STK38	0.52698476
96	PDGFRB	0.51407073
97	IRAK2	0.50644932
98	ADRBK1	0.49160139
99	PTK2	0.46983463
100	PRKCH	0.45938587
101	IRAK3	0.45807207
102	TIE1	0.44675245
103	CAMK1D	0.44244249
104	PRKCQ	0.43668057
105	KIT	0.43462026
106	TYRO3	0.43440936
107	DYRK3	0.43149631
108	MINK1	0.42001092
109	WNK4	0.40688832
110	BMX	0.40551139
111	PRKCE	0.40439401
112	PRKCG	0.39364977
113	CSK	0.39195805
114	LRRK2	0.38601579
115	EGFR	0.38365474
116	MST4	0.36778403
117	MAPK7	0.35669226
118	PIM2	0.35363148
119	PRKAA1	0.35221420
120	ABL1	0.35187254
121	BCR	0.34782189
122	PDGFRA	0.34480399
123	MAP3K6	0.34270294
124	CSNK1D	0.34224101
125	PRKCA	0.33560229
126	IGF1R	0.33315642
127	STK3	0.32339040
128	RET	0.31637525
129	STK10	0.31233022
130	BRD4	0.30286309
131	TAOK1	0.30231901
132	NEK6	0.29786463
133	BMPR2	0.29711331
134	PRKD1	0.28859928
135	MAP3K12	0.27838500
136	MARK2	0.27264538
137	GRK1	0.27181100
138	CDK3	0.27078333
139	CDK7	0.26966784
140	CSNK1E	0.25801664
141	IKBKB	0.23677251
142	CAMK4	0.23386080
143	MAPK9	0.22379065
144	BRSK2	0.21503265
145	PRKD2	0.20717875
146	CHUK	0.20093348
147	DDR2	0.18001808
148	PBK	0.17765191
149	IRAK4	0.15659331

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.88307252
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.25687170
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.20541181
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.10194655
5	Arginine biosynthesis_Homo sapiens_hsa00220	3.01426222
6	Complement and coagulation cascades_Homo sapiens_hsa04610	2.87895328
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.65837320
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.56219566
9	Fatty acid degradation_Homo sapiens_hsa00071	2.49012634
10	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.47664437
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.45021670
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.34693049
13	Histidine metabolism_Homo sapiens_hsa00340	2.13865173
14	Peroxisome_Homo sapiens_hsa04146	2.13178262
15	Butanoate metabolism_Homo sapiens_hsa00650	2.10237315
16	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.07074511
17	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.04793500
18	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.97438851
19	Fatty acid elongation_Homo sapiens_hsa00062	1.88977656
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.87157022
21	PPAR signaling pathway_Homo sapiens_hsa03320	1.86059287
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.84739807
23	Retinol metabolism_Homo sapiens_hsa00830	1.81907222
24	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.81800094
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.80293596
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.79852747
27	Propanoate metabolism_Homo sapiens_hsa00640	1.77271691
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.69025521
29	ABC transporters_Homo sapiens_hsa02010	1.68064764
30	GnRH signaling pathway_Homo sapiens_hsa04912	1.65403742
31	beta-Alanine metabolism_Homo sapiens_hsa00410	1.58134494
32	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.57496972
33	Phenylalanine metabolism_Homo sapiens_hsa00360	1.55394553
34	Caffeine metabolism_Homo sapiens_hsa00232	1.54460926
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.53244846
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.49631287
37	Tyrosine metabolism_Homo sapiens_hsa00350	1.48171761
38	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.43626174
39	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.42433394
40	Bile secretion_Homo sapiens_hsa04976	1.42106097
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.41859306
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41359114
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.36099589
44	Fat digestion and absorption_Homo sapiens_hsa04975	1.34331351
45	VEGF signaling pathway_Homo sapiens_hsa04370	1.31729406
46	Sulfur metabolism_Homo sapiens_hsa00920	1.30849208
47	Pyruvate metabolism_Homo sapiens_hsa00620	1.20428523
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.17306102
49	Folate biosynthesis_Homo sapiens_hsa00790	1.16567040
50	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.10427064
51	Steroid biosynthesis_Homo sapiens_hsa00100	1.08185418
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.08027530
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.06853186
54	Long-term depression_Homo sapiens_hsa04730	1.06126427
55	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.04186581
56	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02962161
57	Choline metabolism in cancer_Homo sapiens_hsa05231	0.97751500
58	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.97305388
59	Carbon metabolism_Homo sapiens_hsa01200	0.97268279
60	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.95832172
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.94277155
62	Phototransduction_Homo sapiens_hsa04744	0.94157316
63	ECM-receptor interaction_Homo sapiens_hsa04512	0.90216024
64	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.88097174
65	Sulfur relay system_Homo sapiens_hsa04122	0.86325951
66	Renin secretion_Homo sapiens_hsa04924	0.83809347
67	Glutathione metabolism_Homo sapiens_hsa00480	0.83432395
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81822549
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.81104391
70	Ras signaling pathway_Homo sapiens_hsa04014	0.80155159
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.78419231
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.78100084
73	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.77556130
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.76268184
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.72645916
76	Serotonergic synapse_Homo sapiens_hsa04726	0.71157690
77	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.68828759
78	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.68393647
79	Lysine degradation_Homo sapiens_hsa00310	0.66001727
80	p53 signaling pathway_Homo sapiens_hsa04115	0.64219892
81	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.63006368
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.62232846
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60649127
84	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.59806295
85	Prion diseases_Homo sapiens_hsa05020	0.58709268
86	One carbon pool by folate_Homo sapiens_hsa00670	0.56752182
87	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.56640376
88	Adherens junction_Homo sapiens_hsa04520	0.56604956
89	Platelet activation_Homo sapiens_hsa04611	0.56574677
90	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.55478056
91	Tight junction_Homo sapiens_hsa04530	0.50854663
92	MicroRNAs in cancer_Homo sapiens_hsa05206	0.50317159
93	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.48277816
94	Endocytosis_Homo sapiens_hsa04144	0.46553306
95	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.45974535
96	Metabolic pathways_Homo sapiens_hsa01100	0.45083293
97	Melanogenesis_Homo sapiens_hsa04916	0.42681283
98	Pentose phosphate pathway_Homo sapiens_hsa00030	0.42066537
99	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.38479786
100	Thyroid cancer_Homo sapiens_hsa05216	0.37992543
101	Glutamatergic synapse_Homo sapiens_hsa04724	0.37304328
102	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.35761868
103	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.34650097
104	Glioma_Homo sapiens_hsa05214	0.34342832
105	Proteoglycans in cancer_Homo sapiens_hsa05205	0.34081829
106	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.33134681
107	Long-term potentiation_Homo sapiens_hsa04720	0.32939936
108	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.29971227
109	MAPK signaling pathway_Homo sapiens_hsa04010	0.29700504
110	Basal cell carcinoma_Homo sapiens_hsa05217	0.26500159
111	FoxO signaling pathway_Homo sapiens_hsa04068	0.25638568
112	Notch signaling pathway_Homo sapiens_hsa04330	0.25637684
113	Acute myeloid leukemia_Homo sapiens_hsa05221	0.25217886
114	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.25062630
115	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.24976882
116	Hippo signaling pathway_Homo sapiens_hsa04390	0.24198081
117	Insulin resistance_Homo sapiens_hsa04931	0.23783522
118	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.23741947
119	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.22847764
120	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.22292329
121	Ether lipid metabolism_Homo sapiens_hsa00565	0.15741248
122	Sphingolipid metabolism_Homo sapiens_hsa00600	0.09045664
123	Galactose metabolism_Homo sapiens_hsa00052	0.08391586
124	Glucagon signaling pathway_Homo sapiens_hsa04922	0.07726802
125	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.07401894
126	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.2352657
127	Mineral absorption_Homo sapiens_hsa04978	-0.2282886
128	Renin-angiotensin system_Homo sapiens_hsa04614	-0.2217557
129	Regulation of autophagy_Homo sapiens_hsa04140	-0.1999535
130	Pertussis_Homo sapiens_hsa05133	-0.1981557
131	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1945494
132	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1934874
133	Circadian rhythm_Homo sapiens_hsa04710	-0.1856531
134	Lysosome_Homo sapiens_hsa04142	-0.1819358
135	Bladder cancer_Homo sapiens_hsa05219	-0.1600338
136	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1529679
137	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.1325555
138	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1315151
139	Amoebiasis_Homo sapiens_hsa05146	-0.1126641
140	African trypanosomiasis_Homo sapiens_hsa05143	-0.0821385
141	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	-0.0570466
142	Hepatitis C_Homo sapiens_hsa05160	-0.0515893
143	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0402252
144	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0151374

SERPINA12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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