ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of respiratory burst (GO:0060267)	7.44035826
2	antibacterial humoral response (GO:0019731)	6.82154014
3	antimicrobial humoral response (GO:0019730)	6.55309308
4	eosinophil chemotaxis (GO:0048245)	6.48587310
5	fructose metabolic process (GO:0006000)	5.83329577
6	eosinophil migration (GO:0072677)	5.79124061
7	angiotensin maturation (GO:0002003)	5.61388785
8	positive regulation of pseudopodium assembly (GO:0031274)	5.60220313
9	NADH metabolic process (GO:0006734)	5.58747690
10	glomerular filtration (GO:0003094)	5.44684033
11	complement activation, classical pathway (GO:0006958)	5.40840264
12	oligosaccharide catabolic process (GO:0009313)	5.29079942
13	regulation of guanylate cyclase activity (GO:0031282)	5.26247664
14	regulation of pseudopodium assembly (GO:0031272)	5.04935246
15	regulation of cellular extravasation (GO:0002691)	4.99430633
16	regulation of respiratory burst (GO:0060263)	4.86585581
17	renal filtration (GO:0097205)	4.83763957
18	chronic inflammatory response (GO:0002544)	4.53488857
19	complement activation (GO:0006956)	4.52310441
20	urea cycle (GO:0000050)	4.47340577
21	positive regulation of guanylate cyclase activity (GO:0031284)	4.46149559
22	regulation of bile acid biosynthetic process (GO:0070857)	4.44023228
23	urea metabolic process (GO:0019627)	4.43078911
24	epoxygenase P450 pathway (GO:0019373)	4.37127638
25	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	4.21285762
26	alkaloid metabolic process (GO:0009820)	4.18852088
27	disruption of cells of other organism (GO:0044364)	4.12068228
28	killing of cells of other organism (GO:0031640)	4.12068228
29	nitrogen cycle metabolic process (GO:0071941)	4.08330453
30	intestinal absorption (GO:0050892)	4.04193255
31	GDP-mannose metabolic process (GO:0019673)	4.00463319
32	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.97173589
33	drug metabolic process (GO:0017144)	3.97054807
34	very-low-density lipoprotein particle assembly (GO:0034379)	3.95974644
35	arginine metabolic process (GO:0006525)	3.94995806
36	regulation of triglyceride catabolic process (GO:0010896)	3.85633150
37	protein activation cascade (GO:0072376)	3.77739143
38	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	3.76395557
39	antigen processing and presentation of endogenous antigen (GO:0019883)	3.66253132
40	drug catabolic process (GO:0042737)	3.64527312
41	vitamin transport (GO:0051180)	3.63861340
42	negative regulation of epidermal cell differentiation (GO:0045605)	3.61653265
43	bile acid and bile salt transport (GO:0015721)	3.58027520
44	phenylpropanoid metabolic process (GO:0009698)	3.57934382
45	defense response to fungus (GO:0050832)	3.57138163
46	diacylglycerol metabolic process (GO:0046339)	3.55175978
47	vitamin A metabolic process (GO:0006776)	3.50322911
48	low-density lipoprotein particle remodeling (GO:0034374)	3.50279415
49	cellular response to zinc ion (GO:0071294)	3.49448642
50	ethanol oxidation (GO:0006069)	3.49406536
51	cellular response to cadmium ion (GO:0071276)	3.46694806
52	regulation of protein glycosylation (GO:0060049)	3.45123366
53	hormone catabolic process (GO:0042447)	3.44504496
54	bile acid metabolic process (GO:0008206)	3.39619865
55	digestion (GO:0007586)	3.35628922
56	xenobiotic catabolic process (GO:0042178)	3.34326375
57	acute-phase response (GO:0006953)	3.31309486
58	humoral immune response (GO:0006959)	3.30199384
59	positive regulation of triglyceride lipase activity (GO:0061365)	3.27849429
60	positive regulation of lipoprotein lipase activity (GO:0051006)	3.27849429
61	fat-soluble vitamin biosynthetic process (GO:0042362)	3.26855935
62	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.24950355
63	plasma lipoprotein particle assembly (GO:0034377)	3.24843322
64	maintenance of gastrointestinal epithelium (GO:0030277)	3.24125390
65	regulation of cGMP biosynthetic process (GO:0030826)	3.23471250
66	plasma lipoprotein particle remodeling (GO:0034369)	3.22707559
67	protein-lipid complex remodeling (GO:0034368)	3.22707559
68	macromolecular complex remodeling (GO:0034367)	3.22707559
69	phospholipid efflux (GO:0033700)	3.22209633
70	glycolipid catabolic process (GO:0019377)	3.14823700
71	lipoprotein transport (GO:0042953)	3.12275144
72	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.11959730
73	L-ascorbic acid metabolic process (GO:0019852)	3.10543688
74	nucleoside diphosphate biosynthetic process (GO:0009133)	3.09355161
75	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.06934512
76	transcytosis (GO:0045056)	3.02243656
77	plasma lipoprotein particle organization (GO:0071827)	3.00272277
78	glycosphingolipid catabolic process (GO:0046479)	2.91176193
79	regulation of cholesterol esterification (GO:0010872)	2.91061133
80	lipoprotein metabolic process (GO:0042157)	2.89232904
81	uronic acid metabolic process (GO:0006063)	2.89197428
82	glucuronate metabolic process (GO:0019585)	2.89197428
83	ERK1 and ERK2 cascade (GO:0070371)	2.88510884
84	negative regulation of leukocyte chemotaxis (GO:0002689)	2.88311485
85	positive regulation of fatty acid biosynthetic process (GO:0045723)	2.88018563
86	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	2.87119965
87	endocrine process (GO:0050886)	2.87119965
88	regulation of systemic arterial blood pressure by hormone (GO:0001990)	2.87119965
89	positive regulation of glycoprotein metabolic process (GO:1903020)	2.86271687
90	negative regulation of epidermis development (GO:0045683)	2.86131230
91	cellular glucuronidation (GO:0052695)	2.84560741
92	protein-lipid complex assembly (GO:0065005)	2.81609680
93	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.79704679
94	protein-lipid complex subunit organization (GO:0071825)	2.78179444
95	positive regulation of lipid catabolic process (GO:0050996)	2.75528309
96	sulfur amino acid catabolic process (GO:0000098)	2.75237862
97	ethanol metabolic process (GO:0006067)	2.73976115
98	regulation of protein activation cascade (GO:2000257)	2.73839881
99	peptide catabolic process (GO:0043171)	2.73681487
100	exogenous drug catabolic process (GO:0042738)	2.72812721

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.74304699
2	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.82967049
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.75529580
4	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.75469506
5	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.60942505
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.60207949
7	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.25372224
8	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.24612003
9	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.86458375
10	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.83285731
11	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.73671162
12	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.61599636
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.59238189
14	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.27827639
15	GATA4_25053715_ChIP-Seq_YYC3_Human	2.15814433
16	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.14741697
17	SOX2_20726797_ChIP-Seq_SW620_Human	2.13163014
18	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.13042118
19	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.07486445
20	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.06993570
21	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.95005379
22	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.88317536
23	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.87631506
24	LXR_22292898_ChIP-Seq_THP-1_Human	1.79244502
25	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.76073234
26	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.75386963
27	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.67760319
28	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.62450350
29	GATA6_25053715_ChIP-Seq_YYC3_Human	1.59960385
30	STAT1_20625510_ChIP-Seq_HELA_Human	1.59360571
31	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.53974662
32	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.53777296
33	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.53348715
34	SA1_27219007_Chip-Seq_Bcells_Human	1.52070083
35	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.50851910
36	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.49481419
37	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.47720590
38	BCOR_27268052_Chip-Seq_Bcells_Human	1.43049920
39	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.42803386
40	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.38251289
41	CTCF_27219007_Chip-Seq_Bcells_Human	1.35102233
42	BCL6_27268052_Chip-Seq_Bcells_Human	1.33214124
43	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.30785300
44	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.29196865
45	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.28055821
46	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.27708600
47	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.22188858
48	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.17459839
49	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.17171716
50	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.13530097
51	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.13269282
52	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.12845352
53	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.12601657
54	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.12319768
55	RACK7_27058665_Chip-Seq_MCF-7_Human	1.12182263
56	EGR1_19032775_ChIP-ChIP_M12_Human	1.11637974
57	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10722116
58	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.10413292
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.09682977
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.07224974
61	P300_27268052_Chip-Seq_Bcells_Human	1.06251490
62	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06096962
63	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.05538161
64	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.03810206
65	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.03518753
66	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.01539977
67	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01334535
68	SOX2_21211035_ChIP-Seq_LN229_Human	1.01282138
69	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.99795711
70	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.97620120
71	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.97041958
72	E2F1_20622854_ChIP-Seq_HELA_Human	0.94748205
73	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.94200104
74	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.93047334
75	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.92565657
76	MYC_19829295_ChIP-Seq_ESCs_Human	0.92443942
77	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91770310
78	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.91729486
79	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91567577
80	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.91304827
81	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.89837644
82	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.89671293
83	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.88152375
84	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.87230439
85	VDR_24763502_ChIP-Seq_THP-1_Human	0.86241510
86	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.84810187
87	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.84567103
88	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.84464150
89	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.84278880
90	CEBPB_22108803_ChIP-Seq_LS180_Human	0.83065594
91	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.82656276
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.82377705
93	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.81864580
94	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.80952375
95	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.80116428
96	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.78858954
97	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.78180603
98	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.77959967
99	ERA_21632823_ChIP-Seq_H3396_Human	0.77478601
100	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.77467909

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	7.06961063
2	MP0002139_abnormal_hepatobiliary_system	5.83778473
3	MP0001666_abnormal_nutrient_absorption	4.39593794
4	MP0005085_abnormal_gallbladder_physiolo	3.99167948
5	MP0004019_abnormal_vitamin_homeostasis	3.63813336
6	MP0005365_abnormal_bile_salt	3.52086031
7	MP0009840_abnormal_foam_cell	3.04282956
8	MP0010155_abnormal_intestine_physiology	2.94424324
9	MP0002138_abnormal_hepatobiliary_system	2.69165734
10	MP0009379_abnormal_foot_pigmentation	2.63211292
11	MP0003806_abnormal_nucleotide_metabolis	2.42791345
12	MP0010329_abnormal_lipoprotein_level	2.30779541
13	MP0002876_abnormal_thyroid_physiology	2.30578960
14	MP0010234_abnormal_vibrissa_follicle	2.22998986
15	MP0003879_abnormal_hair_cell	1.92599483
16	MP0003183_abnormal_peptide_metabolism	1.87969464
17	MP0005332_abnormal_amino_acid	1.87447718
18	MP0003868_abnormal_feces_composition	1.84245380
19	MP0003724_increased_susceptibility_to	1.82333708
20	MP0005645_abnormal_hypothalamus_physiol	1.80881920
21	MP0005166_decreased_susceptibility_to	1.78953709
22	MP0001664_abnormal_digestion	1.74503917
23	MP0003252_abnormal_bile_duct	1.69599669
24	MP0003195_calcinosis	1.68185408
25	MP0008875_abnormal_xenobiotic_pharmacok	1.65543929
26	MP0000013_abnormal_adipose_tissue	1.65174891
27	MP0003866_abnormal_defecation	1.54495014
28	MP0005387_immune_system_phenotype	1.53088998
29	MP0001790_abnormal_immune_system	1.53088998
30	MP0000490_abnormal_crypts_of	1.48530272
31	MP0009643_abnormal_urine_homeostasis	1.47004914
32	MP0009785_altered_susceptibility_to	1.44762261
33	MP0001663_abnormal_digestive_system	1.43808579
34	MP0005058_abnormal_lysosome_morphology	1.41835691
35	MP0002118_abnormal_lipid_homeostasis	1.40096729
36	MP0001845_abnormal_inflammatory_respons	1.38482226
37	MP0006082_CNS_inflammation	1.33302696
38	MP0003303_peritoneal_inflammation	1.30508466
39	MP0003436_decreased_susceptibility_to	1.28223725
40	MP0003718_maternal_effect	1.27600565
41	MP0001764_abnormal_homeostasis	1.25205287
42	MP0000477_abnormal_intestine_morphology	1.24409898
43	MP0009764_decreased_sensitivity_to	1.24376848
44	MP0005025_abnormal_response_to	1.23716313
45	MP0010352_gastrointestinal_tract_polyps	1.20485417
46	MP0005409_darkened_coat_color	1.17389022
47	MP0002148_abnormal_hypersensitivity_rea	1.17019362
48	MP0005381_digestive/alimentary_phenotyp	1.16180616
49	MP0001873_stomach_inflammation	1.14373462
50	MP0001835_abnormal_antigen_presentation	1.10937672
51	MP0000462_abnormal_digestive_system	1.10015432
52	MP0004858_abnormal_nervous_system	1.08703990
53	MP0000609_abnormal_liver_physiology	1.07546087
54	MP0004264_abnormal_extraembryonic_tissu	1.07379191
55	MP0003075_altered_response_to	1.03897052
56	MP0003191_abnormal_cellular_cholesterol	1.03748717
57	MP0008469_abnormal_protein_level	1.03431137
58	MP0005636_abnormal_mineral_homeostasis	1.02195124
59	MP0005584_abnormal_enzyme/coenzyme_acti	1.01872131
60	MP0003300_gastrointestinal_ulcer	0.98401415
61	MP0001765_abnormal_ion_homeostasis	0.97723208
62	MP0001533_abnormal_skeleton_physiology	0.97332687
63	MP0005535_abnormal_body_temperature	0.96534595
64	MP0001501_abnormal_sleep_pattern	0.95558432
65	MP0000538_abnormal_urinary_bladder	0.94541830
66	MP0004147_increased_porphyrin_level	0.91634401
67	MP0008872_abnormal_physiological_respon	0.91632187
68	MP0001756_abnormal_urination	0.91005977
69	MP0002166_altered_tumor_susceptibility	0.90732303
70	MP0003638_abnormal_response/metabolism_	0.88799993
71	MP0005448_abnormal_energy_balance	0.88677632
72	MP0000604_amyloidosis	0.88252316
73	MP0002136_abnormal_kidney_physiology	0.88236342
74	MP0010386_abnormal_urinary_bladder	0.86856688
75	MP0005451_abnormal_body_composition	0.83366409
76	MP0002254_reproductive_system_inflammat	0.82329762
77	MP0003959_abnormal_lean_body	0.80257490
78	MP0005165_increased_susceptibility_to	0.79524271
79	MP0002277_abnormal_respiratory_mucosa	0.77865271
80	MP0005319_abnormal_enzyme/_coenzyme	0.77816349
81	MP0005000_abnormal_immune_tolerance	0.76463177
82	MP0001800_abnormal_humoral_immune	0.74208827
83	MP0003878_abnormal_ear_physiology	0.73630733
84	MP0005377_hearing/vestibular/ear_phenot	0.73630733
85	MP0001485_abnormal_pinna_reflex	0.73437409
86	MP0002796_impaired_skin_barrier	0.72999201
87	MP0009333_abnormal_splenocyte_physiolog	0.71070688
88	MP0002971_abnormal_brown_adipose	0.69904680
89	MP0009642_abnormal_blood_homeostasis	0.69213077
90	MP0002078_abnormal_glucose_homeostasis	0.69168210
91	MP0002419_abnormal_innate_immunity	0.67650943
92	MP0005671_abnormal_response_to	0.66554664
93	MP0000685_abnormal_immune_system	0.65548737
94	MP0000678_abnormal_parathyroid_gland	0.64063180
95	MP0005408_hypopigmentation	0.63260931
96	MP0002723_abnormal_immune_serum	0.61776391
97	MP0002006_tumorigenesis	0.61634743
98	MP0005395_other_phenotype	0.60042836
99	MP0001819_abnormal_immune_cell	0.59254300
100	MP0000249_abnormal_blood_vessel	0.58258851

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	7.30678181
2	Systemic lupus erythematosus (HP:0002725)	6.80028907
3	Malnutrition (HP:0004395)	5.63906396
4	Hypobetalipoproteinemia (HP:0003563)	4.46531376
5	Complement deficiency (HP:0004431)	4.20778238
6	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.20260105
7	Abnormality of proline metabolism (HP:0010907)	4.05354244
8	Hydroxyprolinuria (HP:0003080)	4.05354244
9	Glomerulonephritis (HP:0000099)	4.00273632
10	Glycosuria (HP:0003076)	3.90782601
11	Abnormality of urine glucose concentration (HP:0011016)	3.90782601
12	Abnormality of complement system (HP:0005339)	3.90747557
13	Proximal tubulopathy (HP:0000114)	3.86379248
14	Xanthomatosis (HP:0000991)	3.74869140
15	Nausea (HP:0002018)	3.62519653
16	Congenital sensorineural hearing impairment (HP:0008527)	3.51902111
17	Nephritis (HP:0000123)	3.34000850
18	Fat malabsorption (HP:0002630)	3.27423427
19	Prolonged partial thromboplastin time (HP:0003645)	3.24886372
20	Abnormality of vitamin B metabolism (HP:0004340)	3.19658709
21	Ileus (HP:0002595)	3.15382625
22	Chronic diarrhea (HP:0002028)	3.11634149
23	Deep venous thrombosis (HP:0002625)	3.10813825
24	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.08706737
25	Hyperphosphaturia (HP:0003109)	3.04221801
26	Hyperuricemia (HP:0002149)	3.03561669
27	Increased purine levels (HP:0004368)	3.03561669
28	Alkalosis (HP:0001948)	3.01897148
29	Widely patent fontanelles and sutures (HP:0004492)	2.93410434
30	Confusion (HP:0001289)	2.88530784
31	Abnormality of vitamin metabolism (HP:0100508)	2.76178633
32	Abnormal urine phosphate concentration (HP:0012599)	2.76101112
33	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.68551091
34	Hyperammonemia (HP:0001987)	2.67463045
35	Eczematoid dermatitis (HP:0000976)	2.65426876
36	Pancreatitis (HP:0001733)	2.63616385
37	Abnormality of purine metabolism (HP:0004352)	2.62069842
38	Abnormality of nucleobase metabolism (HP:0010932)	2.60479693
39	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.59804687
40	Dicarboxylic aciduria (HP:0003215)	2.59804687
41	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.57742690
42	Abnormality of pyrimidine metabolism (HP:0004353)	2.57010277
43	Steatorrhea (HP:0002570)	2.55712034
44	Hypophosphatemia (HP:0002148)	2.51843342
45	Metabolic alkalosis (HP:0200114)	2.50036344
46	Hypolipoproteinemia (HP:0010981)	2.48317211
47	Decreased circulating renin level (HP:0003351)	2.45770637
48	Tongue fasciculations (HP:0001308)	2.43735118
49	Stridor (HP:0010307)	2.42022465
50	Metabolic acidosis (HP:0001942)	2.36943276
51	Abnormality of macrophages (HP:0004311)	2.35125810
52	Lethargy (HP:0001254)	2.31676310
53	Vacuolated lymphocytes (HP:0001922)	2.29523302
54	Generalized aminoaciduria (HP:0002909)	2.27620038
55	Delayed CNS myelination (HP:0002188)	2.25345046
56	Myopathic facies (HP:0002058)	2.22734210
57	Amyloidosis (HP:0011034)	2.20907939
58	Irritability (HP:0000737)	2.20821436
59	Muscle fibrillation (HP:0010546)	2.20740351
60	Abnormality of fatty-acid metabolism (HP:0004359)	2.20399146
61	Wide cranial sutures (HP:0010537)	2.19779856
62	Gout (HP:0001997)	2.17831310
63	Recurrent gram-negative bacterial infections (HP:0005420)	2.15622640
64	Hypotension (HP:0002615)	2.13431393
65	Nephrolithiasis (HP:0000787)	2.11509634
66	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.10891031
67	Abnormality of serine family amino acid metabolism (HP:0010894)	2.10716041
68	Abnormality of glycine metabolism (HP:0010895)	2.10716041
69	Joint hemorrhage (HP:0005261)	2.09684189
70	Acanthocytosis (HP:0001927)	2.08300600
71	Intrahepatic cholestasis (HP:0001406)	2.01527873
72	Polyphagia (HP:0002591)	2.01134045
73	Gastrointestinal infarctions (HP:0005244)	1.98824676
74	Pigmentary retinal degeneration (HP:0001146)	1.96581067
75	Hyperglycinuria (HP:0003108)	1.94907608
76	Vomiting (HP:0002013)	1.94841110
77	Potter facies (HP:0002009)	1.94552938
78	Facial shape deformation (HP:0011334)	1.94552938
79	Diaphragmatic weakness (HP:0009113)	1.92751130
80	Cerebral palsy (HP:0100021)	1.92159378
81	Purpura (HP:0000979)	1.92099536
82	Hypothermia (HP:0002045)	1.91206148
83	Thin bony cortex (HP:0002753)	1.91167362
84	Ketosis (HP:0001946)	1.90161890
85	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.90077750
86	Orchitis (HP:0100796)	1.89167153
87	Facial diplegia (HP:0001349)	1.88865383
88	Renal tubular dysfunction (HP:0000124)	1.88258094
89	Growth hormone excess (HP:0000845)	1.87234501
90	Elevated erythrocyte sedimentation rate (HP:0003565)	1.85098474
91	Renal tubular acidosis (HP:0001947)	1.84779056
92	Dysostosis multiplex (HP:0000943)	1.84724172
93	Progressive neurologic deterioration (HP:0002344)	1.83722853
94	Abdominal distention (HP:0003270)	1.83208761
95	Recurrent pneumonia (HP:0006532)	1.82455256
96	Bulbar palsy (HP:0001283)	1.82402158
97	Abnormality of magnesium homeostasis (HP:0004921)	1.82106085
98	Neonatal onset (HP:0003623)	1.81271851
99	Petechiae (HP:0000967)	1.80962324
100	Abnormality of alkaline phosphatase activity (HP:0004379)	1.79976435

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	6.49827200
2	ERN1	4.98420134
3	LMTK2	3.61070945
4	PRKG2	3.26630432
5	PTK6	2.35723546
6	TYK2	2.21947056
7	EPHB2	2.12606900
8	EPHA2	2.11694928
9	MAP3K12	2.11360649
10	VRK2	2.07368538
11	FGFR4	2.05138431
12	TESK2	1.99401038
13	RIPK1	1.84885448
14	GRK6	1.79105920
15	MAP2K2	1.78441539
16	MAP2K6	1.68574115
17	MYLK	1.66525444
18	TBK1	1.61628055
19	ADRBK2	1.60660289
20	TESK1	1.59466408
21	MAP3K11	1.58075755
22	MAP4K1	1.58056665
23	TAOK1	1.50696202
24	GRK1	1.42366406
25	ABL2	1.34967569
26	MST1R	1.33183638
27	STK24	1.31066014
28	EPHA3	1.26335609
29	MAP3K1	1.26330225
30	MATK	1.24934034
31	IKBKE	1.20522642
32	OXSR1	1.10711570
33	ZAP70	1.09091141
34	MST4	1.02983055
35	DAPK2	1.00909095
36	EPHB1	0.99470737
37	RIPK4	0.99146540
38	PRKACG	0.97787704
39	PIK3CA	0.96347740
40	BRAF	0.94684493
41	PKN2	0.91366702
42	CSK	0.90945832
43	DDR2	0.90033426
44	BMX	0.89904035
45	ARAF	0.89438912
46	JAK2	0.88632790
47	IRAK3	0.88597310
48	PDPK1	0.87611559
49	FRK	0.83749923
50	PIM2	0.82195917
51	FGFR3	0.82172444
52	NLK	0.79951241
53	MAP3K10	0.79543879
54	IKBKB	0.78154429
55	PRKCA	0.76644864
56	TLK1	0.76292397
57	FER	0.72611585
58	BLK	0.71376889
59	TXK	0.70627294
60	PRKCZ	0.70011341
61	ERBB2	0.66125385
62	STK39	0.65058986
63	MAPK11	0.63897931
64	MAP3K2	0.62412423
65	CAMK2D	0.61451697
66	CLK1	0.60851232
67	TAOK2	0.59968752
68	PRKCI	0.59639945
69	KIT	0.58900883
70	PRKCQ	0.57248079
71	MARK3	0.56852277
72	DAPK3	0.56837228
73	CDC42BPA	0.56735208
74	PDK1	0.53801679
75	JAK3	0.52765093
76	CDK19	0.52488953
77	LYN	0.51586532
78	TNIK	0.49899344
79	JAK1	0.48517583
80	SYK	0.45871404
81	PRKAA2	0.43274097
82	RPS6KC1	0.41144078
83	RPS6KL1	0.41144078
84	PRKG1	0.40924629
85	ADRBK1	0.40917272
86	RPS6KA6	0.40408803
87	GSK3A	0.39843879
88	BCKDK	0.36981890
89	PRKACA	0.36762485
90	DAPK1	0.36337438
91	PRKCD	0.36326849
92	IRAK1	0.33880604
93	NME1	0.33685854
94	SRC	0.31921571
95	PRKCE	0.30843609
96	EPHA4	0.30832524
97	MAP3K3	0.30640841
98	KDR	0.29637923
99	IGF1R	0.29246813
100	LCK	0.29029765

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	4.42230535
2	Fat digestion and absorption_Homo sapiens_hsa04975	3.78351854
3	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.38264262
4	Sulfur metabolism_Homo sapiens_hsa00920	3.06505259
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.73692848
6	Asthma_Homo sapiens_hsa05310	2.69497470
7	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.45157023
8	Chemical carcinogenesis_Homo sapiens_hsa05204	2.26007606
9	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.15662904
10	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.15031979
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.13815734
12	Histidine metabolism_Homo sapiens_hsa00340	2.04059138
13	Renin-angiotensin system_Homo sapiens_hsa04614	2.02463208
14	Mineral absorption_Homo sapiens_hsa04978	1.98383064
15	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.94892366
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.91068488
17	Retinol metabolism_Homo sapiens_hsa00830	1.89784804
18	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.85570150
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.78110894
20	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.71377607
21	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.70127237
22	Complement and coagulation cascades_Homo sapiens_hsa04610	1.68026379
23	Caffeine metabolism_Homo sapiens_hsa00232	1.64523462
24	Glutathione metabolism_Homo sapiens_hsa00480	1.61029548
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.60384276
26	Allograft rejection_Homo sapiens_hsa05330	1.57005565
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.53409508
28	Fatty acid degradation_Homo sapiens_hsa00071	1.52782191
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.52626475
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.51061619
31	Bile secretion_Homo sapiens_hsa04976	1.50587079
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.44730162
33	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.44311924
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.43666670
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.36084360
36	Sulfur relay system_Homo sapiens_hsa04122	1.36032928
37	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.33817850
38	Phenylalanine metabolism_Homo sapiens_hsa00360	1.31035415
39	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.30647157
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.24120911
41	Protein digestion and absorption_Homo sapiens_hsa04974	1.21391579
42	Peroxisome_Homo sapiens_hsa04146	1.16154280
43	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.14605049
44	Arginine and proline metabolism_Homo sapiens_hsa00330	1.13119936
45	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.08192002
46	Other glycan degradation_Homo sapiens_hsa00511	0.95674297
47	Galactose metabolism_Homo sapiens_hsa00052	0.94303349
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.90748570
49	Glycerolipid metabolism_Homo sapiens_hsa00561	0.89431788
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.86654048
51	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.84372221
52	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.83976618
53	Pertussis_Homo sapiens_hsa05133	0.82199106
54	Folate biosynthesis_Homo sapiens_hsa00790	0.78453495
55	Antigen processing and presentation_Homo sapiens_hsa04612	0.78110501
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.75457642
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71853516
58	Leishmaniasis_Homo sapiens_hsa05140	0.71585249
59	Butanoate metabolism_Homo sapiens_hsa00650	0.70072856
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69577535
61	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.69161056
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63193488
63	Prion diseases_Homo sapiens_hsa05020	0.62477855
64	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61892735
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61427035
66	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.58615895
67	Sphingolipid metabolism_Homo sapiens_hsa00600	0.56204340
68	Pancreatic secretion_Homo sapiens_hsa04972	0.54550838
69	Pentose phosphate pathway_Homo sapiens_hsa00030	0.54408265
70	Fatty acid metabolism_Homo sapiens_hsa01212	0.49869419
71	Oxidative phosphorylation_Homo sapiens_hsa00190	0.43661155
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42030939
73	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.39998544
74	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.38818529
75	Viral myocarditis_Homo sapiens_hsa05416	0.38619059
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.38407923
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37128667
78	Metabolic pathways_Homo sapiens_hsa01100	0.36593404
79	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.35505281
80	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35075887
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.33645167
82	Vibrio cholerae infection_Homo sapiens_hsa05110	0.32856747
83	Chemokine signaling pathway_Homo sapiens_hsa04062	0.29781136
84	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29117519
85	Fatty acid elongation_Homo sapiens_hsa00062	0.27583530
86	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.26934950
87	Carbon metabolism_Homo sapiens_hsa01200	0.26461199
88	African trypanosomiasis_Homo sapiens_hsa05143	0.25600348
89	Lysosome_Homo sapiens_hsa04142	0.25161412
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.24599184
91	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.22056457
92	Tuberculosis_Homo sapiens_hsa05152	0.21725233
93	Phagosome_Homo sapiens_hsa04145	0.20827074
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.16957517
95	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.16452389
96	Parkinsons disease_Homo sapiens_hsa05012	0.16277954
97	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.13216687
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.12215262
99	Toxoplasmosis_Homo sapiens_hsa05145	0.11166145
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.10845656

SERPINA2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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