SERPINA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)8.64304051
2regulation of fibrinolysis (GO:0051917)8.58594657
3exogenous drug catabolic process (GO:0042738)8.32151318
4glyoxylate metabolic process (GO:0046487)8.19838613
5drug catabolic process (GO:0042737)8.17081631
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.83349102
7L-phenylalanine catabolic process (GO:0006559)7.83349102
8epoxygenase P450 pathway (GO:0019373)7.36304594
9L-phenylalanine metabolic process (GO:0006558)7.25685280
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25685280
11regulation of protein activation cascade (GO:2000257)7.15659226
12fibrinolysis (GO:0042730)6.78820679
13peptidyl-glutamic acid carboxylation (GO:0017187)6.72479649
14protein carboxylation (GO:0018214)6.72479649
15omega-hydroxylase P450 pathway (GO:0097267)6.72417297
16complement activation, alternative pathway (GO:0006957)6.68281595
17regulation of complement activation (GO:0030449)6.64717801
18urea metabolic process (GO:0019627)6.49335491
19cellular glucuronidation (GO:0052695)6.24237617
20blood coagulation, intrinsic pathway (GO:0007597)6.13911835
21negative regulation of cholesterol transport (GO:0032375)6.04105036
22negative regulation of sterol transport (GO:0032372)6.04105036
23glucuronate metabolic process (GO:0019585)5.94347321
24uronic acid metabolic process (GO:0006063)5.94347321
25nitrogen cycle metabolic process (GO:0071941)5.88037794
26ethanol oxidation (GO:0006069)5.83885199
27drug metabolic process (GO:0017144)5.64385830
28bile acid biosynthetic process (GO:0006699)5.64329287
29urea cycle (GO:0000050)5.60694191
30serine family amino acid catabolic process (GO:0009071)5.60498823
31aromatic amino acid family catabolic process (GO:0009074)5.59056967
32phenylpropanoid metabolic process (GO:0009698)5.52875582
33oxidative demethylation (GO:0070989)5.52480269
34regulation of plasminogen activation (GO:0010755)5.44438730
35regulation of triglyceride catabolic process (GO:0010896)5.38172072
36bile acid metabolic process (GO:0008206)5.28792933
37glycine metabolic process (GO:0006544)5.13652134
38negative regulation of blood coagulation (GO:0030195)5.02173727
39negative regulation of hemostasis (GO:1900047)5.02173727
40triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.96485818
41phospholipid efflux (GO:0033700)4.87663797
42intestinal cholesterol absorption (GO:0030299)4.80245780
43acylglycerol homeostasis (GO:0055090)4.79477425
44triglyceride homeostasis (GO:0070328)4.79477425
45ethanol metabolic process (GO:0006067)4.73734444
46bile acid and bile salt transport (GO:0015721)4.72857757
47regulation of cholesterol esterification (GO:0010872)4.62470700
48negative regulation of coagulation (GO:0050819)4.59746568
49protein activation cascade (GO:0072376)4.56487620
50macromolecular complex remodeling (GO:0034367)4.55991897
51plasma lipoprotein particle remodeling (GO:0034369)4.55991897
52protein-lipid complex remodeling (GO:0034368)4.55991897
53negative regulation of wound healing (GO:0061045)4.50964941
54amino-acid betaine metabolic process (GO:0006577)4.50442952
55very-low-density lipoprotein particle assembly (GO:0034379)4.50299297
56cholesterol efflux (GO:0033344)4.45922640
57high-density lipoprotein particle remodeling (GO:0034375)4.42972428
58positive regulation of hemostasis (GO:1900048)4.38433174
59positive regulation of blood coagulation (GO:0030194)4.38433174
60acute-phase response (GO:0006953)4.33485970
61S-adenosylmethionine metabolic process (GO:0046500)4.32946199
62negative regulation of protein activation cascade (GO:2000258)4.29867480
63positive regulation of lipoprotein lipase activity (GO:0051006)4.29171309
64positive regulation of triglyceride lipase activity (GO:0061365)4.29171309
65tyrosine metabolic process (GO:0006570)4.28251438
66alkaloid metabolic process (GO:0009820)4.27911291
67negative regulation of lipase activity (GO:0060192)4.22331058
68serine family amino acid metabolic process (GO:0009069)4.16555689
69regulation of humoral immune response (GO:0002920)4.14461089
70hormone catabolic process (GO:0042447)4.08748606
71complement activation, classical pathway (GO:0006958)4.07122834
72complement activation (GO:0006956)4.05723281
73positive regulation of coagulation (GO:0050820)4.04673299
74arginine metabolic process (GO:0006525)4.00708135
75reverse cholesterol transport (GO:0043691)3.98594987
76polyketide metabolic process (GO:0030638)3.91358608
77doxorubicin metabolic process (GO:0044598)3.91358608
78daunorubicin metabolic process (GO:0044597)3.91358608
79heme transport (GO:0015886)3.87202573
80plasma lipoprotein particle clearance (GO:0034381)3.83155991
81fat-soluble vitamin biosynthetic process (GO:0042362)3.79776277
82alpha-amino acid catabolic process (GO:1901606)3.77321127
83flavonoid metabolic process (GO:0009812)3.76820510
84regulation of lipoprotein particle clearance (GO:0010984)3.74509764
85negative regulation of complement activation (GO:0045916)3.73268917
86imidazole-containing compound metabolic process (GO:0052803)3.69824504
87response to mercury ion (GO:0046689)3.69034860
88steroid catabolic process (GO:0006706)3.66708310
89aromatic amino acid family metabolic process (GO:0009072)3.63714656
90glutamate metabolic process (GO:0006536)3.63400738
91plasma lipoprotein particle assembly (GO:0034377)3.62289563
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.61751763
93indole-containing compound catabolic process (GO:0042436)3.59686179
94indolalkylamine catabolic process (GO:0046218)3.59686179
95tryptophan catabolic process (GO:0006569)3.59686179
96serine family amino acid biosynthetic process (GO:0009070)3.56930771
97plasma lipoprotein particle organization (GO:0071827)3.49999338
98negative regulation of fatty acid biosynthetic process (GO:0045717)3.49717579
99primary alcohol catabolic process (GO:0034310)3.47546179
100xenobiotic metabolic process (GO:0006805)3.47095115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.19665649
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.81346884
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.02019535
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.68085983
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.86723287
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.72986521
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.43879073
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.08684131
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04119014
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.49691747
11* FOXA2_19822575_ChIP-Seq_HepG2_Human2.48722516
12HNF4A_19822575_ChIP-Seq_HepG2_Human2.44839100
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.18088914
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3669500
15HTT_18923047_ChIP-ChIP_STHdh_Human1.50357576
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.48852475
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46882985
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35934355
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.32235308
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24967312
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.17796091
22GATA4_25053715_ChIP-Seq_YYC3_Human1.17414582
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17053982
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13252154
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11456513
26* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10318477
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08485477
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05425164
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04685009
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03580959
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.02106967
32CDX2_20551321_ChIP-Seq_CACO-2_Human0.98959213
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98507892
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94369158
35GATA6_25053715_ChIP-Seq_YYC3_Human0.92269561
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91991150
37PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90064144
38SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88977149
39SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86071718
40IRF8_22096565_ChIP-ChIP_GC-B_Human0.85751765
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84441216
42FOXA1_25552417_ChIP-Seq_VCAP_Human0.83298884
43KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80013321
44NFE2_27457419_Chip-Seq_LIVER_Mouse0.78662695
45SOX2_20726797_ChIP-Seq_SW620_Human0.78001557
46SOX2_21211035_ChIP-Seq_LN229_Human0.77402087
47* CEBPB_22108803_ChIP-Seq_LS180_Human0.76859550
48TCF4_18268006_ChIP-ChIP_LS174T_Human0.75977178
49FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73236108
50CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.72312958
51HNFA_21074721_ChIP-Seq_CACO-2_Human0.72047671
52AR_20517297_ChIP-Seq_VCAP_Human0.70841640
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70481157
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.70359468
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.69898416
56RARG_19884340_ChIP-ChIP_MEFs_Mouse0.69768497
57SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68807395
58PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67878082
59LXR_22292898_ChIP-Seq_THP-1_Human0.66203341
60TP53_18474530_ChIP-ChIP_U2OS_Human0.65918150
61CBP_21632823_ChIP-Seq_H3396_Human0.64805788
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.64690282
63FOXO3_23340844_ChIP-Seq_DLD1_Human0.63489753
64CLOCK_20551151_ChIP-Seq_293T_Human0.62102620
65RAC3_21632823_ChIP-Seq_H3396_Human0.62062785
66EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.61926264
67EZH2_27294783_Chip-Seq_NPCs_Mouse0.61612807
68PHF8_20622853_ChIP-Seq_HELA_Human0.60629753
69GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.59197553
70P53_21459846_ChIP-Seq_SAOS-2_Human0.58845350
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58727797
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58684804
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.58270504
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.57743230
75CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56222168
76NFYA_21822215_ChIP-Seq_K562_Human0.55583769
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.55387244
78SUZ12_27294783_Chip-Seq_NPCs_Mouse0.55100802
79PIAS1_25552417_ChIP-Seq_VCAP_Human0.54667010
80SMAD1_18555785_Chip-Seq_ESCs_Mouse0.54446589
81GATA6_21074721_ChIP-Seq_CACO-2_Human0.54268452
82CBX2_22325352_ChIP-Seq_293T-Rex_Human0.53860682
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.53004433
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.52902854
85GATA1_22025678_ChIP-Seq_K562_Human0.51973177
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.51686077
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.51663911
88MYC_19915707_ChIP-ChIP_AK7_Human0.51402045
89STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.51302199
90ESRRB_18555785_Chip-Seq_ESCs_Mouse0.51298360
91IRF1_19129219_ChIP-ChIP_H3396_Human0.51290497
92RAD21_21589869_ChIP-Seq_MESCs_Mouse0.50155755
93RUNX1_27457419_Chip-Seq_LIVER_Mouse0.50040979
94ETV2_25802403_ChIP-Seq_MESCs_Mouse0.49910222
95GATA3_21867929_ChIP-Seq_CD8_Mouse0.48923772
96JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.48882405
97POU5F1_16518401_ChIP-PET_MESCs_Mouse0.48817924
98BCAT_22108803_ChIP-Seq_LS180_Human0.48797759
99NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.48749028
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.48667182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.61215702
2MP0005360_urolithiasis6.28092414
3MP0005085_abnormal_gallbladder_physiolo6.13756831
4MP0005365_abnormal_bile_salt6.05557200
5MP0008875_abnormal_xenobiotic_pharmacok5.22493772
6MP0003195_calcinosis5.16978120
7MP0002138_abnormal_hepatobiliary_system4.57289643
8MP0003868_abnormal_feces_composition4.01306115
9MP0003252_abnormal_bile_duct3.89809813
10MP0001666_abnormal_nutrient_absorption3.81197000
11MP0009697_abnormal_copulation3.03675906
12MP0010329_abnormal_lipoprotein_level2.93978428
13MP0009840_abnormal_foam_cell2.60939637
14MP0002876_abnormal_thyroid_physiology2.38409170
15MP0005332_abnormal_amino_acid2.30369188
16MP0003806_abnormal_nucleotide_metabolis2.21052890
17MP0000609_abnormal_liver_physiology1.82674575
18MP0002118_abnormal_lipid_homeostasis1.73737726
19MP0001764_abnormal_homeostasis1.67624489
20MP0003191_abnormal_cellular_cholesterol1.61156496
21MP0005408_hypopigmentation1.45487325
22MP0004019_abnormal_vitamin_homeostasis1.34089383
23MP0010368_abnormal_lymphatic_system1.27026121
24MP0005319_abnormal_enzyme/_coenzyme1.19840741
25MP0002132_abnormal_respiratory_system1.07509779
26MP0000598_abnormal_liver_morphology1.04997813
27MP0001915_intracranial_hemorrhage1.01918426
28MP0005451_abnormal_body_composition1.00197347
29MP0001661_extended_life_span0.99211345
30MP0009643_abnormal_urine_homeostasis0.98135748
31MP0005584_abnormal_enzyme/coenzyme_acti0.97724977
32MP0003656_abnormal_erythrocyte_physiolo0.91770605
33MP0000604_amyloidosis0.91160703
34MP0009053_abnormal_anal_canal0.89545060
35MP0003186_abnormal_redox_activity0.87171662
36MP0009642_abnormal_blood_homeostasis0.85572187
37MP0005376_homeostasis/metabolism_phenot0.79136940
38MP0003879_abnormal_hair_cell0.78604552
39MP0005058_abnormal_lysosome_morphology0.77219606
40MP0008469_abnormal_protein_level0.76829785
41MP0005187_abnormal_penis_morphology0.76373268
42MP0005636_abnormal_mineral_homeostasis0.75173120
43MP0005395_other_phenotype0.73031468
44MP0009763_increased_sensitivity_to0.72005259
45MP0003011_delayed_dark_adaptation0.70938546
46MP0003638_abnormal_response/metabolism_0.67575610
47MP0002971_abnormal_brown_adipose0.67392991
48MP0000566_synostosis0.65932323
49MP0002168_other_aberrant_phenotype0.65617340
50MP0005464_abnormal_platelet_physiology0.64329681
51MP0005670_abnormal_white_adipose0.64201867
52MP0002078_abnormal_glucose_homeostasis0.56992548
53MP0003690_abnormal_glial_cell0.56831029
54MP0002089_abnormal_postnatal_growth/wei0.53369008
55MP0009764_decreased_sensitivity_to0.52531154
56MP0002282_abnormal_trachea_morphology0.52420780
57MP0005535_abnormal_body_temperature0.47664436
58MP0008874_decreased_physiological_sensi0.45523605
59MP0005266_abnormal_metabolism0.45352139
60MP0008872_abnormal_physiological_respon0.44689980
61MP0005334_abnormal_fat_pad0.43912381
62MP0005084_abnormal_gallbladder_morpholo0.43716342
63MP0000249_abnormal_blood_vessel0.42565213
64MP0005220_abnormal_exocrine_pancreas0.42075285
65MP0005023_abnormal_wound_healing0.42063050
66MP0005164_abnormal_response_to0.38611855
67MP0006036_abnormal_mitochondrial_physio0.38608497
68MP0010386_abnormal_urinary_bladder0.37978762
69MP0005448_abnormal_energy_balance0.37628380
70MP0004883_abnormal_blood_vessel0.36717924
71MP0003959_abnormal_lean_body0.36178034
72MP0002249_abnormal_larynx_morphology0.35270061
73MP0003718_maternal_effect0.33787821
74MP0003329_amyloid_beta_deposits0.33644893
75MP0003953_abnormal_hormone_level0.33330247
76MP0005083_abnormal_biliary_tract0.32895060
77MP0002928_abnormal_bile_duct0.32184439
78MP0004272_abnormal_basement_membrane0.31115792
79MP0003075_altered_response_to0.30444846
80MP0009785_altered_susceptibility_to0.29050679
81MP0002136_abnormal_kidney_physiology0.28921077
82MP0001756_abnormal_urination0.27818427
83MP0003122_maternal_imprinting0.27016468
84MP0009115_abnormal_fat_cell0.26907523
85MP0005167_abnormal_blood-brain_barrier0.25202275
86MP0005166_decreased_susceptibility_to0.24864740
87MP0008873_increased_physiological_sensi0.24717123
88MP0003172_abnormal_lysosome_physiology0.24716805
89MP0005197_abnormal_uvea_morphology0.23385603
90MP0002090_abnormal_vision0.23245296
91MP0005647_abnormal_sex_gland0.22473884
92MP0004130_abnormal_muscle_cell0.21583053
93MP0002970_abnormal_white_adipose0.21151449
94MP0000920_abnormal_myelination0.20926144
95MP0003632_abnormal_nervous_system0.20674412
96MP0000639_abnormal_adrenal_gland0.20631949
97MP0001845_abnormal_inflammatory_respons0.19106016
98MP0001851_eye_inflammation0.16547817
99MP0009765_abnormal_xenobiotic_induced0.16040003
100MP0005377_hearing/vestibular/ear_phenot0.14709077

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)9.18540394
2Abnormality of aromatic amino acid family metabolism (HP:0004338)8.10728707
3Hypobetalipoproteinemia (HP:0003563)8.08103926
4Complement deficiency (HP:0004431)7.95476291
5Joint hemorrhage (HP:0005261)6.44920511
6Abnormality of complement system (HP:0005339)6.39853088
7Systemic lupus erythematosus (HP:0002725)5.81035180
8Conjugated hyperbilirubinemia (HP:0002908)5.55234662
9Hyperlipoproteinemia (HP:0010980)5.32602830
10Xanthomatosis (HP:0000991)5.13084054
11Intrahepatic cholestasis (HP:0001406)5.00235829
12Glomerulonephritis (HP:0000099)4.91170167
13Abnormality of the common coagulation pathway (HP:0010990)4.83439548
14Hypolipoproteinemia (HP:0010981)4.70248315
15Abnormality of pyrimidine metabolism (HP:0004353)4.70149176
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.93587749
17Fat malabsorption (HP:0002630)3.90365114
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.75286943
19Spontaneous abortion (HP:0005268)3.71928429
20Recurrent gram-negative bacterial infections (HP:0005420)3.66008406
21Abnormality of the intrinsic pathway (HP:0010989)3.62676606
22Nephritis (HP:0000123)3.46767014
23Steatorrhea (HP:0002570)3.41944495
24Hyperglycinemia (HP:0002154)3.35771844
25Hyperammonemia (HP:0001987)3.22510979
26Hypercholesterolemia (HP:0003124)3.16290005
27Vascular calcification (HP:0004934)3.16186721
28Generalized aminoaciduria (HP:0002909)3.13655968
29Hemorrhage of the eye (HP:0011885)3.09405666
30Rickets (HP:0002748)3.06839499
31Reduced antithrombin III activity (HP:0001976)3.03789197
32Hypoalphalipoproteinemia (HP:0003233)3.01498153
33Menorrhagia (HP:0000132)2.93843737
34Abnormality of methionine metabolism (HP:0010901)2.92122526
35Gingival bleeding (HP:0000225)2.91892425
36Delayed CNS myelination (HP:0002188)2.90322760
37Osteomalacia (HP:0002749)2.87031851
38Mitral stenosis (HP:0001718)2.86324718
39Abnormality of serine family amino acid metabolism (HP:0010894)2.83280627
40Abnormality of glycine metabolism (HP:0010895)2.83280627
41Epidermoid cyst (HP:0200040)2.82194900
42Cardiovascular calcification (HP:0011915)2.79435270
43Purpura (HP:0000979)2.74666343
44Abnormality of nucleobase metabolism (HP:0010932)2.61295092
45Hyperglycinuria (HP:0003108)2.59248190
46Abnormality of serum amino acid levels (HP:0003112)2.51576892
47Pulmonary embolism (HP:0002204)2.46356364
48Abnormal gallbladder physiology (HP:0012438)2.42359519
49Cholecystitis (HP:0001082)2.42359519
50Thrombophlebitis (HP:0004418)2.40005436
51Arthropathy (HP:0003040)2.38619086
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34494460
53Hyperbilirubinemia (HP:0002904)2.29941086
54Abnormality of the Achilles tendon (HP:0005109)2.25701853
55Hepatocellular carcinoma (HP:0001402)2.21357525
56Fair hair (HP:0002286)2.20686569
57Hyperphosphaturia (HP:0003109)2.20354545
58Abnormality of urine glucose concentration (HP:0011016)2.12451412
59Glycosuria (HP:0003076)2.12451412
60Metabolic acidosis (HP:0001942)2.08584130
61Abnormality of vitamin metabolism (HP:0100508)2.05584506
62Myocardial infarction (HP:0001658)2.05164342
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.03798639
64Hypophosphatemic rickets (HP:0004912)2.00120740
65Deep venous thrombosis (HP:0002625)11.3469303
66Abnormality of monocarboxylic acid metabolism (HP:0010996)10.0961619
67Bifid scrotum (HP:0000048)1.98747214
68Irritability (HP:0000737)1.93072960
69Cholelithiasis (HP:0001081)1.90938854
70Poikilocytosis (HP:0004447)1.89734635
71Elevated alkaline phosphatase (HP:0003155)1.87822122
72Hydroxyprolinuria (HP:0003080)1.87090070
73Abnormality of proline metabolism (HP:0010907)1.87090070
74Acanthocytosis (HP:0001927)1.84570377
75Ketosis (HP:0001946)1.83558660
76Abnormal gallbladder morphology (HP:0012437)1.82807849
77Gangrene (HP:0100758)1.82369406
78Abnormal urine phosphate concentration (HP:0012599)1.78710026
79Abnormal enzyme/coenzyme activity (HP:0012379)1.77542099
80Neonatal hypoglycemia (HP:0001998)1.76541799
81Hypochromic microcytic anemia (HP:0004840)1.76070967
82Abnormality of alkaline phosphatase activity (HP:0004379)1.72701879
83Potter facies (HP:0002009)1.70671262
84Facial shape deformation (HP:0011334)1.70671262
85Enlarged kidneys (HP:0000105)1.69845948
86Skin nodule (HP:0200036)1.68268484
87Retinal atrophy (HP:0001105)1.67641657
88Pancreatitis (HP:0001733)1.66491762
89Abnormality of purine metabolism (HP:0004352)1.65570304
90Abnormal tarsal ossification (HP:0008369)1.63265269
91Sensorimotor neuropathy (HP:0007141)1.62586930
92Increased mean platelet volume (HP:0011877)1.62131801
93Increased serum ferritin (HP:0003281)1.61607317
94Epistaxis (HP:0000421)1.59105161
95Abnormal biliary tract physiology (HP:0012439)1.58415775
96Bile duct proliferation (HP:0001408)1.58415775
97Hypochromic anemia (HP:0001931)1.56859513
98Abnormality of iron homeostasis (HP:0011031)1.56718042
99Joint swelling (HP:0001386)1.56025329
100Abnormality of fatty-acid metabolism (HP:0004359)1.54819161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR45.63679760
2ERN14.67198055
3PIK3CG3.46885094
4RIPK13.43046150
5FGFR32.95404610
6LATS12.48530734
7PIK3CA2.44348526
8MAP3K32.40485141
9TRIB32.38030129
10TYK21.94005564
11BCKDK1.90208804
12MAP3K121.89887025
13PRKACG1.85107123
14SIK11.80640326
15PRKAA21.75620135
16NEK91.73178412
17ICK1.68060200
18MAP3K21.58870950
19STK38L1.57916790
20MAPK111.56323263
21MST1R1.53582968
22PDPK11.52461507
23IRAK31.47785096
24TBK11.41051887
25PRKCG1.37477606
26NTRK31.35619786
27FGFR21.32869183
28PRPF4B1.23318435
29MAP2K41.21279330
30LATS21.20568335
31IGF1R1.10329817
32TGFBR21.08832181
33ABL21.07804994
34ERBB21.01583486
35CDK121.00932997
36EPHA21.00234215
37MYLK0.98096401
38NLK0.97628418
39EPHA30.95940917
40EIF2AK10.95165407
41PRKCZ0.94007946
42PKN20.93413869
43PDK10.92968894
44RET0.91935447
45STK380.90968658
46EPHA40.86562722
47WNK40.86471110
48MAP2K30.85655027
49DYRK1B0.84139234
50MAP3K10.82022794
51JAK10.81070355
52KSR20.80997231
53PDGFRA0.80845155
54FGFR10.80441001
55CSNK1D0.79249645
56MAP3K110.77832950
57MAPKAPK30.77526129
58LMTK20.74779675
59PRKAA10.73974410
60PDK20.72631923
61MAP3K50.70917292
62SGK4940.70340139
63SGK2230.70340139
64PRKG10.69464176
65PRKACA0.69144887
66TAOK20.68743899
67SGK10.68434054
68JAK20.62421258
69PINK10.61220745
70CSF1R0.61209179
71ACVR1B0.59483271
72SCYL20.56895279
73AKT30.55797512
74SGK30.53432783
75MAP2K20.52742125
76CDK60.52600529
77RPS6KA30.51271405
78TAOK30.50256966
79MET0.50074768
80FER0.49180420
81PRKCB0.48860167
82INSRR0.48280234
83PTK60.48208444
84ARAF0.47764151
85SGK20.47255555
86PRKCA0.46031609
87CSNK1E0.45709625
88SRC0.43726170
89ERBB40.43131285
90CAMK1D0.42667625
91BCR0.41650207
92DAPK20.38480702
93GSK3A0.38079876
94ZAP700.36295997
95CAMKK10.36120220
96CSNK2A10.35875283
97CDK40.35697484
98STK160.35508433
99MAP3K70.35085242
100RPS6KB10.35030188

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.09338293
2Caffeine metabolism_Homo sapiens_hsa002324.05572049
3Primary bile acid biosynthesis_Homo sapiens_hsa001204.03254175
4Complement and coagulation cascades_Homo sapiens_hsa046103.83365472
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.55897018
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.31303066
7Retinol metabolism_Homo sapiens_hsa008303.28348811
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.88043425
9Chemical carcinogenesis_Homo sapiens_hsa052042.84844976
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.84251976
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.77869195
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.70745178
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.58029700
14Arginine biosynthesis_Homo sapiens_hsa002202.48637617
15Phenylalanine metabolism_Homo sapiens_hsa003602.47554554
16Fatty acid degradation_Homo sapiens_hsa000712.34131020
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.23212703
18Tyrosine metabolism_Homo sapiens_hsa003502.06207632
19Butanoate metabolism_Homo sapiens_hsa006502.02956715
20Bile secretion_Homo sapiens_hsa049761.86880003
21Histidine metabolism_Homo sapiens_hsa003401.79809939
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78334357
23Tryptophan metabolism_Homo sapiens_hsa003801.78324823
24Starch and sucrose metabolism_Homo sapiens_hsa005001.62292220
25Linoleic acid metabolism_Homo sapiens_hsa005911.60657957
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54339737
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53189831
28Peroxisome_Homo sapiens_hsa041461.43739495
29PPAR signaling pathway_Homo sapiens_hsa033201.41716637
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.41081208
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.34795274
32beta-Alanine metabolism_Homo sapiens_hsa004101.26436034
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24755603
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.24402448
35Fat digestion and absorption_Homo sapiens_hsa049751.19785358
36Vitamin B6 metabolism_Homo sapiens_hsa007501.12270693
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12107534
38Staphylococcus aureus infection_Homo sapiens_hsa051501.10528887
39Biosynthesis of amino acids_Homo sapiens_hsa012301.10523888
40Pyruvate metabolism_Homo sapiens_hsa006201.09606157
41Arginine and proline metabolism_Homo sapiens_hsa003301.06909685
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04851555
43Arachidonic acid metabolism_Homo sapiens_hsa005900.97641178
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97365998
45Propanoate metabolism_Homo sapiens_hsa006400.93124370
46Fatty acid metabolism_Homo sapiens_hsa012120.89989591
47Carbon metabolism_Homo sapiens_hsa012000.89295244
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.84980646
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84038830
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81093135
51Prion diseases_Homo sapiens_hsa050200.80486685
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78120720
53ABC transporters_Homo sapiens_hsa020100.69750068
54Sulfur metabolism_Homo sapiens_hsa009200.69629227
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69145047
56One carbon pool by folate_Homo sapiens_hsa006700.68784658
57Sulfur relay system_Homo sapiens_hsa041220.60609456
58Lysine degradation_Homo sapiens_hsa003100.56122988
59Steroid biosynthesis_Homo sapiens_hsa001000.47863652
60Metabolic pathways_Homo sapiens_hsa011000.44364150
61Glycerolipid metabolism_Homo sapiens_hsa005610.40698642
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.38309003
63Fatty acid elongation_Homo sapiens_hsa000620.36411040
64Vitamin digestion and absorption_Homo sapiens_hsa049770.36213136
65Fructose and mannose metabolism_Homo sapiens_hsa000510.29430458
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29249225
67Pertussis_Homo sapiens_hsa051330.26768145
68Other glycan degradation_Homo sapiens_hsa005110.22480480
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20347937
70Pentose phosphate pathway_Homo sapiens_hsa000300.18869443
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18130424
72Insulin resistance_Homo sapiens_hsa049310.18006087
73Glutathione metabolism_Homo sapiens_hsa004800.16629508
74Renin-angiotensin system_Homo sapiens_hsa046140.14560323
75Galactose metabolism_Homo sapiens_hsa000520.10361694
76Fatty acid biosynthesis_Homo sapiens_hsa000610.10301432
77Glucagon signaling pathway_Homo sapiens_hsa049220.07809713
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.03990657
79Folate biosynthesis_Homo sapiens_hsa007900.02759772
80Selenocompound metabolism_Homo sapiens_hsa004500.02513492
81Ether lipid metabolism_Homo sapiens_hsa00565-0.2160707
82Type II diabetes mellitus_Homo sapiens_hsa04930-0.2037623
83Insulin signaling pathway_Homo sapiens_hsa04910-0.1731463
84Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1617999
85Nitrogen metabolism_Homo sapiens_hsa00910-0.1519885
86Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1431381
87Amoebiasis_Homo sapiens_hsa05146-0.1312462
88Protein digestion and absorption_Homo sapiens_hsa04974-0.1238789
89African trypanosomiasis_Homo sapiens_hsa05143-0.1163818
90Pancreatic secretion_Homo sapiens_hsa04972-0.1081681
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0997112
92Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0823318
93N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0775788
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0759969
95Serotonergic synapse_Homo sapiens_hsa04726-0.0645355
96Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0617126
97Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0615868
98AMPK signaling pathway_Homo sapiens_hsa04152-0.0596614
99Sphingolipid metabolism_Homo sapiens_hsa00600-0.0423292
100Mineral absorption_Homo sapiens_hsa04978-0.0236950

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