ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of fibrinolysis (GO:0051918)	8.64304051
2	regulation of fibrinolysis (GO:0051917)	8.58594657
3	exogenous drug catabolic process (GO:0042738)	8.32151318
4	glyoxylate metabolic process (GO:0046487)	8.19838613
5	drug catabolic process (GO:0042737)	8.17081631
6	L-phenylalanine catabolic process (GO:0006559)	7.83349102
7	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.83349102
8	epoxygenase P450 pathway (GO:0019373)	7.36304594
9	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.25685280
10	L-phenylalanine metabolic process (GO:0006558)	7.25685280
11	regulation of protein activation cascade (GO:2000257)	7.15659226
12	fibrinolysis (GO:0042730)	6.78820679
13	peptidyl-glutamic acid carboxylation (GO:0017187)	6.72479649
14	protein carboxylation (GO:0018214)	6.72479649
15	omega-hydroxylase P450 pathway (GO:0097267)	6.72417297
16	complement activation, alternative pathway (GO:0006957)	6.68281595
17	regulation of complement activation (GO:0030449)	6.64717801
18	urea metabolic process (GO:0019627)	6.49335491
19	cellular glucuronidation (GO:0052695)	6.24237617
20	blood coagulation, intrinsic pathway (GO:0007597)	6.13911835
21	negative regulation of sterol transport (GO:0032372)	6.04105036
22	negative regulation of cholesterol transport (GO:0032375)	6.04105036
23	uronic acid metabolic process (GO:0006063)	5.94347321
24	glucuronate metabolic process (GO:0019585)	5.94347321
25	nitrogen cycle metabolic process (GO:0071941)	5.88037794
26	ethanol oxidation (GO:0006069)	5.83885199
27	drug metabolic process (GO:0017144)	5.64385830
28	bile acid biosynthetic process (GO:0006699)	5.64329287
29	urea cycle (GO:0000050)	5.60694191
30	serine family amino acid catabolic process (GO:0009071)	5.60498823
31	aromatic amino acid family catabolic process (GO:0009074)	5.59056967
32	phenylpropanoid metabolic process (GO:0009698)	5.52875582
33	oxidative demethylation (GO:0070989)	5.52480269
34	regulation of plasminogen activation (GO:0010755)	5.44438730
35	regulation of triglyceride catabolic process (GO:0010896)	5.38172072
36	bile acid metabolic process (GO:0008206)	5.28792933
37	glycine metabolic process (GO:0006544)	5.13652134
38	negative regulation of hemostasis (GO:1900047)	5.02173727
39	negative regulation of blood coagulation (GO:0030195)	5.02173727
40	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.96485818
41	phospholipid efflux (GO:0033700)	4.87663797
42	intestinal cholesterol absorption (GO:0030299)	4.80245780
43	triglyceride homeostasis (GO:0070328)	4.79477425
44	acylglycerol homeostasis (GO:0055090)	4.79477425
45	ethanol metabolic process (GO:0006067)	4.73734444
46	bile acid and bile salt transport (GO:0015721)	4.72857757
47	regulation of cholesterol esterification (GO:0010872)	4.62470700
48	negative regulation of coagulation (GO:0050819)	4.59746568
49	protein activation cascade (GO:0072376)	4.56487620
50	protein-lipid complex remodeling (GO:0034368)	4.55991897
51	macromolecular complex remodeling (GO:0034367)	4.55991897
52	plasma lipoprotein particle remodeling (GO:0034369)	4.55991897
53	negative regulation of wound healing (GO:0061045)	4.50964941
54	amino-acid betaine metabolic process (GO:0006577)	4.50442952
55	very-low-density lipoprotein particle assembly (GO:0034379)	4.50299297
56	cholesterol efflux (GO:0033344)	4.45922640
57	high-density lipoprotein particle remodeling (GO:0034375)	4.42972428
58	positive regulation of blood coagulation (GO:0030194)	4.38433174
59	positive regulation of hemostasis (GO:1900048)	4.38433174
60	acute-phase response (GO:0006953)	4.33485970
61	S-adenosylmethionine metabolic process (GO:0046500)	4.32946199
62	negative regulation of protein activation cascade (GO:2000258)	4.29867480
63	positive regulation of lipoprotein lipase activity (GO:0051006)	4.29171309
64	positive regulation of triglyceride lipase activity (GO:0061365)	4.29171309
65	tyrosine metabolic process (GO:0006570)	4.28251438
66	alkaloid metabolic process (GO:0009820)	4.27911291
67	negative regulation of lipase activity (GO:0060192)	4.22331058
68	serine family amino acid metabolic process (GO:0009069)	4.16555689
69	regulation of humoral immune response (GO:0002920)	4.14461089
70	hormone catabolic process (GO:0042447)	4.08748606
71	complement activation, classical pathway (GO:0006958)	4.07122834
72	complement activation (GO:0006956)	4.05723281
73	positive regulation of coagulation (GO:0050820)	4.04673299
74	arginine metabolic process (GO:0006525)	4.00708135
75	reverse cholesterol transport (GO:0043691)	3.98594987
76	polyketide metabolic process (GO:0030638)	3.91358608
77	doxorubicin metabolic process (GO:0044598)	3.91358608
78	daunorubicin metabolic process (GO:0044597)	3.91358608
79	heme transport (GO:0015886)	3.87202573
80	plasma lipoprotein particle clearance (GO:0034381)	3.83155991
81	fat-soluble vitamin biosynthetic process (GO:0042362)	3.79776277
82	alpha-amino acid catabolic process (GO:1901606)	3.77321127
83	flavonoid metabolic process (GO:0009812)	3.76820510
84	regulation of lipoprotein particle clearance (GO:0010984)	3.74509764
85	negative regulation of complement activation (GO:0045916)	3.73268917
86	imidazole-containing compound metabolic process (GO:0052803)	3.69824504
87	response to mercury ion (GO:0046689)	3.69034860
88	steroid catabolic process (GO:0006706)	3.66708310
89	aromatic amino acid family metabolic process (GO:0009072)	3.63714656
90	glutamate metabolic process (GO:0006536)	3.63400738
91	plasma lipoprotein particle assembly (GO:0034377)	3.62289563
92	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.61751763
93	indole-containing compound catabolic process (GO:0042436)	3.59686179
94	indolalkylamine catabolic process (GO:0046218)	3.59686179
95	tryptophan catabolic process (GO:0006569)	3.59686179
96	serine family amino acid biosynthetic process (GO:0009070)	3.56930771
97	plasma lipoprotein particle organization (GO:0071827)	3.49999338
98	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.49717579
99	primary alcohol catabolic process (GO:0034310)	3.47546179
100	xenobiotic metabolic process (GO:0006805)	3.47095115

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	RXR_22158963_ChIP-Seq_LIVER_Mouse	7.19665649
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.81346884
3	PPARA_22158963_ChIP-Seq_LIVER_Mouse	6.02019535
4	LXR_22158963_ChIP-Seq_LIVER_Mouse	5.68085983
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.86723287
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.72986521
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.43879073
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	4.08684131
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	4.04119014
10	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.49691747
11	* FOXA2_19822575_ChIP-Seq_HepG2_Human	2.48722516
12	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.44839100
13	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.18088914
14	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.3669500
15	HTT_18923047_ChIP-ChIP_STHdh_Human	1.50357576
16	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.48852475
17	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.46882985
18	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.35934355
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.32235308
20	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.24967312
21	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.17796091
22	GATA4_25053715_ChIP-Seq_YYC3_Human	1.17414582
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17053982
24	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.13252154
25	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.11456513
26	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.10318477
27	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.08485477
28	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.05425164
29	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.04685009
30	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.03580959
31	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.02106967
32	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.98959213
33	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.98507892
34	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.94369158
35	GATA6_25053715_ChIP-Seq_YYC3_Human	0.92269561
36	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.91991150
37	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.90064144
38	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.88977149
39	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.86071718
40	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.85751765
41	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.84441216
42	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.83298884
43	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.80013321
44	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.78662695
45	SOX2_20726797_ChIP-Seq_SW620_Human	0.78001557
46	SOX2_21211035_ChIP-Seq_LN229_Human	0.77402087
47	* CEBPB_22108803_ChIP-Seq_LS180_Human	0.76859550
48	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.75977178
49	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.73236108
50	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.72312958
51	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.72047671
52	AR_20517297_ChIP-Seq_VCAP_Human	0.70841640
53	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.70481157
54	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.70359468
55	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.69898416
56	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.69768497
57	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.68807395
58	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.67878082
59	LXR_22292898_ChIP-Seq_THP-1_Human	0.66203341
60	TP53_18474530_ChIP-ChIP_U2OS_Human	0.65918150
61	CBP_21632823_ChIP-Seq_H3396_Human	0.64805788
62	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.64690282
63	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.63489753
64	CLOCK_20551151_ChIP-Seq_293T_Human	0.62102620
65	RAC3_21632823_ChIP-Seq_H3396_Human	0.62062785
66	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.61926264
67	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.61612807
68	PHF8_20622853_ChIP-Seq_HELA_Human	0.60629753
69	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.59197553
70	P53_21459846_ChIP-Seq_SAOS-2_Human	0.58845350
71	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.58727797
72	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.58684804
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.58270504
74	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.57743230
75	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.56222168
76	NFYA_21822215_ChIP-Seq_K562_Human	0.55583769
77	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.55387244
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.55100802
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.54667010
80	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.54446589
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.54268452
82	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.53860682
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.53004433
84	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.52902854
85	GATA1_22025678_ChIP-Seq_K562_Human	0.51973177
86	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.51686077
87	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.51663911
88	MYC_19915707_ChIP-ChIP_AK7_Human	0.51402045
89	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.51302199
90	ESRRB_18555785_Chip-Seq_ESCs_Mouse	0.51298360
91	IRF1_19129219_ChIP-ChIP_H3396_Human	0.51290497
92	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.50155755
93	RUNX1_27457419_Chip-Seq_LIVER_Mouse	0.50040979
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.49910222
95	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.48923772
96	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.48882405
97	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.48817924
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.48797759
99	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.48749028
100	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.48667182

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	9.61215702
2	MP0005360_urolithiasis	6.28092414
3	MP0005085_abnormal_gallbladder_physiolo	6.13756831
4	MP0005365_abnormal_bile_salt	6.05557200
5	MP0008875_abnormal_xenobiotic_pharmacok	5.22493772
6	MP0003195_calcinosis	5.16978120
7	MP0002138_abnormal_hepatobiliary_system	4.57289643
8	MP0003868_abnormal_feces_composition	4.01306115
9	MP0003252_abnormal_bile_duct	3.89809813
10	MP0001666_abnormal_nutrient_absorption	3.81197000
11	MP0009697_abnormal_copulation	3.03675906
12	MP0010329_abnormal_lipoprotein_level	2.93978428
13	MP0009840_abnormal_foam_cell	2.60939637
14	MP0002876_abnormal_thyroid_physiology	2.38409170
15	MP0005332_abnormal_amino_acid	2.30369188
16	MP0003806_abnormal_nucleotide_metabolis	2.21052890
17	MP0000609_abnormal_liver_physiology	1.82674575
18	MP0002118_abnormal_lipid_homeostasis	1.73737726
19	MP0001764_abnormal_homeostasis	1.67624489
20	MP0003191_abnormal_cellular_cholesterol	1.61156496
21	MP0005408_hypopigmentation	1.45487325
22	MP0004019_abnormal_vitamin_homeostasis	1.34089383
23	MP0010368_abnormal_lymphatic_system	1.27026121
24	MP0005319_abnormal_enzyme/_coenzyme	1.19840741
25	MP0002132_abnormal_respiratory_system	1.07509779
26	MP0000598_abnormal_liver_morphology	1.04997813
27	MP0001915_intracranial_hemorrhage	1.01918426
28	MP0005451_abnormal_body_composition	1.00197347
29	MP0001661_extended_life_span	0.99211345
30	MP0009643_abnormal_urine_homeostasis	0.98135748
31	MP0005584_abnormal_enzyme/coenzyme_acti	0.97724977
32	MP0003656_abnormal_erythrocyte_physiolo	0.91770605
33	MP0000604_amyloidosis	0.91160703
34	MP0009053_abnormal_anal_canal	0.89545060
35	MP0003186_abnormal_redox_activity	0.87171662
36	MP0009642_abnormal_blood_homeostasis	0.85572187
37	MP0005376_homeostasis/metabolism_phenot	0.79136940
38	MP0003879_abnormal_hair_cell	0.78604552
39	MP0005058_abnormal_lysosome_morphology	0.77219606
40	MP0008469_abnormal_protein_level	0.76829785
41	MP0005187_abnormal_penis_morphology	0.76373268
42	MP0005636_abnormal_mineral_homeostasis	0.75173120
43	MP0005395_other_phenotype	0.73031468
44	MP0009763_increased_sensitivity_to	0.72005259
45	MP0003011_delayed_dark_adaptation	0.70938546
46	MP0003638_abnormal_response/metabolism_	0.67575610
47	MP0002971_abnormal_brown_adipose	0.67392991
48	MP0000566_synostosis	0.65932323
49	MP0002168_other_aberrant_phenotype	0.65617340
50	MP0005464_abnormal_platelet_physiology	0.64329681
51	MP0005670_abnormal_white_adipose	0.64201867
52	MP0002078_abnormal_glucose_homeostasis	0.56992548
53	MP0003690_abnormal_glial_cell	0.56831029
54	MP0002089_abnormal_postnatal_growth/wei	0.53369008
55	MP0009764_decreased_sensitivity_to	0.52531154
56	MP0002282_abnormal_trachea_morphology	0.52420780
57	MP0005535_abnormal_body_temperature	0.47664436
58	MP0008874_decreased_physiological_sensi	0.45523605
59	MP0005266_abnormal_metabolism	0.45352139
60	MP0008872_abnormal_physiological_respon	0.44689980
61	MP0005334_abnormal_fat_pad	0.43912381
62	MP0005084_abnormal_gallbladder_morpholo	0.43716342
63	MP0000249_abnormal_blood_vessel	0.42565213
64	MP0005220_abnormal_exocrine_pancreas	0.42075285
65	MP0005023_abnormal_wound_healing	0.42063050
66	MP0005164_abnormal_response_to	0.38611855
67	MP0006036_abnormal_mitochondrial_physio	0.38608497
68	MP0010386_abnormal_urinary_bladder	0.37978762
69	MP0005448_abnormal_energy_balance	0.37628380
70	MP0004883_abnormal_blood_vessel	0.36717924
71	MP0003959_abnormal_lean_body	0.36178034
72	MP0002249_abnormal_larynx_morphology	0.35270061
73	MP0003718_maternal_effect	0.33787821
74	MP0003329_amyloid_beta_deposits	0.33644893
75	MP0003953_abnormal_hormone_level	0.33330247
76	MP0005083_abnormal_biliary_tract	0.32895060
77	MP0002928_abnormal_bile_duct	0.32184439
78	MP0004272_abnormal_basement_membrane	0.31115792
79	MP0003075_altered_response_to	0.30444846
80	MP0009785_altered_susceptibility_to	0.29050679
81	MP0002136_abnormal_kidney_physiology	0.28921077
82	MP0001756_abnormal_urination	0.27818427
83	MP0003122_maternal_imprinting	0.27016468
84	MP0009115_abnormal_fat_cell	0.26907523
85	MP0005167_abnormal_blood-brain_barrier	0.25202275
86	MP0005166_decreased_susceptibility_to	0.24864740
87	MP0008873_increased_physiological_sensi	0.24717123
88	MP0003172_abnormal_lysosome_physiology	0.24716805
89	MP0005197_abnormal_uvea_morphology	0.23385603
90	MP0002090_abnormal_vision	0.23245296
91	MP0005647_abnormal_sex_gland	0.22473884
92	MP0004130_abnormal_muscle_cell	0.21583053
93	MP0002970_abnormal_white_adipose	0.21151449
94	MP0000920_abnormal_myelination	0.20926144
95	MP0003632_abnormal_nervous_system	0.20674412
96	MP0000639_abnormal_adrenal_gland	0.20631949
97	MP0001845_abnormal_inflammatory_respons	0.19106016
98	MP0001851_eye_inflammation	0.16547817
99	MP0009765_abnormal_xenobiotic_induced	0.16040003
100	MP0005377_hearing/vestibular/ear_phenot	0.14709077

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged partial thromboplastin time (HP:0003645)	9.18540394
2	Abnormality of aromatic amino acid family metabolism (HP:0004338)	8.10728707
3	Hypobetalipoproteinemia (HP:0003563)	8.08103926
4	Complement deficiency (HP:0004431)	7.95476291
5	Joint hemorrhage (HP:0005261)	6.44920511
6	Abnormality of complement system (HP:0005339)	6.39853088
7	Systemic lupus erythematosus (HP:0002725)	5.81035180
8	Conjugated hyperbilirubinemia (HP:0002908)	5.55234662
9	Hyperlipoproteinemia (HP:0010980)	5.32602830
10	Xanthomatosis (HP:0000991)	5.13084054
11	Intrahepatic cholestasis (HP:0001406)	5.00235829
12	Glomerulonephritis (HP:0000099)	4.91170167
13	Abnormality of the common coagulation pathway (HP:0010990)	4.83439548
14	Hypolipoproteinemia (HP:0010981)	4.70248315
15	Abnormality of pyrimidine metabolism (HP:0004353)	4.70149176
16	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.93587749
17	Fat malabsorption (HP:0002630)	3.90365114
18	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.75286943
19	Spontaneous abortion (HP:0005268)	3.71928429
20	Recurrent gram-negative bacterial infections (HP:0005420)	3.66008406
21	Abnormality of the intrinsic pathway (HP:0010989)	3.62676606
22	Nephritis (HP:0000123)	3.46767014
23	Steatorrhea (HP:0002570)	3.41944495
24	Hyperglycinemia (HP:0002154)	3.35771844
25	Hyperammonemia (HP:0001987)	3.22510979
26	Hypercholesterolemia (HP:0003124)	3.16290005
27	Vascular calcification (HP:0004934)	3.16186721
28	Generalized aminoaciduria (HP:0002909)	3.13655968
29	Hemorrhage of the eye (HP:0011885)	3.09405666
30	Rickets (HP:0002748)	3.06839499
31	Reduced antithrombin III activity (HP:0001976)	3.03789197
32	Hypoalphalipoproteinemia (HP:0003233)	3.01498153
33	Menorrhagia (HP:0000132)	2.93843737
34	Abnormality of methionine metabolism (HP:0010901)	2.92122526
35	Gingival bleeding (HP:0000225)	2.91892425
36	Delayed CNS myelination (HP:0002188)	2.90322760
37	Osteomalacia (HP:0002749)	2.87031851
38	Mitral stenosis (HP:0001718)	2.86324718
39	Abnormality of serine family amino acid metabolism (HP:0010894)	2.83280627
40	Abnormality of glycine metabolism (HP:0010895)	2.83280627
41	Epidermoid cyst (HP:0200040)	2.82194900
42	Cardiovascular calcification (HP:0011915)	2.79435270
43	Purpura (HP:0000979)	2.74666343
44	Abnormality of nucleobase metabolism (HP:0010932)	2.61295092
45	Hyperglycinuria (HP:0003108)	2.59248190
46	Abnormality of serum amino acid levels (HP:0003112)	2.51576892
47	Pulmonary embolism (HP:0002204)	2.46356364
48	Abnormal gallbladder physiology (HP:0012438)	2.42359519
49	Cholecystitis (HP:0001082)	2.42359519
50	Thrombophlebitis (HP:0004418)	2.40005436
51	Arthropathy (HP:0003040)	2.38619086
52	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.34494460
53	Hyperbilirubinemia (HP:0002904)	2.29941086
54	Abnormality of the Achilles tendon (HP:0005109)	2.25701853
55	Hepatocellular carcinoma (HP:0001402)	2.21357525
56	Fair hair (HP:0002286)	2.20686569
57	Hyperphosphaturia (HP:0003109)	2.20354545
58	Abnormality of urine glucose concentration (HP:0011016)	2.12451412
59	Glycosuria (HP:0003076)	2.12451412
60	Metabolic acidosis (HP:0001942)	2.08584130
61	Abnormality of vitamin metabolism (HP:0100508)	2.05584506
62	Myocardial infarction (HP:0001658)	2.05164342
63	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.03798639
64	Hypophosphatemic rickets (HP:0004912)	2.00120740
65	Deep venous thrombosis (HP:0002625)	11.3469303
66	Abnormality of monocarboxylic acid metabolism (HP:0010996)	10.0961619
67	Bifid scrotum (HP:0000048)	1.98747214
68	Irritability (HP:0000737)	1.93072960
69	Cholelithiasis (HP:0001081)	1.90938854
70	Poikilocytosis (HP:0004447)	1.89734635
71	Elevated alkaline phosphatase (HP:0003155)	1.87822122
72	Hydroxyprolinuria (HP:0003080)	1.87090070
73	Abnormality of proline metabolism (HP:0010907)	1.87090070
74	Acanthocytosis (HP:0001927)	1.84570377
75	Ketosis (HP:0001946)	1.83558660
76	Abnormal gallbladder morphology (HP:0012437)	1.82807849
77	Gangrene (HP:0100758)	1.82369406
78	Abnormal urine phosphate concentration (HP:0012599)	1.78710026
79	Abnormal enzyme/coenzyme activity (HP:0012379)	1.77542099
80	Neonatal hypoglycemia (HP:0001998)	1.76541799
81	Hypochromic microcytic anemia (HP:0004840)	1.76070967
82	Abnormality of alkaline phosphatase activity (HP:0004379)	1.72701879
83	Facial shape deformation (HP:0011334)	1.70671262
84	Potter facies (HP:0002009)	1.70671262
85	Enlarged kidneys (HP:0000105)	1.69845948
86	Skin nodule (HP:0200036)	1.68268484
87	Retinal atrophy (HP:0001105)	1.67641657
88	Pancreatitis (HP:0001733)	1.66491762
89	Abnormality of purine metabolism (HP:0004352)	1.65570304
90	Abnormal tarsal ossification (HP:0008369)	1.63265269
91	Sensorimotor neuropathy (HP:0007141)	1.62586930
92	Increased mean platelet volume (HP:0011877)	1.62131801
93	Increased serum ferritin (HP:0003281)	1.61607317
94	Epistaxis (HP:0000421)	1.59105161
95	Abnormal biliary tract physiology (HP:0012439)	1.58415775
96	Bile duct proliferation (HP:0001408)	1.58415775
97	Hypochromic anemia (HP:0001931)	1.56859513
98	Abnormality of iron homeostasis (HP:0011031)	1.56718042
99	Joint swelling (HP:0001386)	1.56025329
100	Abnormality of fatty-acid metabolism (HP:0004359)	1.54819161

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FGFR4	5.63679760
2	ERN1	4.67198055
3	PIK3CG	3.46885094
4	RIPK1	3.43046150
5	FGFR3	2.95404610
6	LATS1	2.48530734
7	PIK3CA	2.44348526
8	MAP3K3	2.40485141
9	TRIB3	2.38030129
10	TYK2	1.94005564
11	BCKDK	1.90208804
12	MAP3K12	1.89887025
13	PRKACG	1.85107123
14	SIK1	1.80640326
15	PRKAA2	1.75620135
16	NEK9	1.73178412
17	ICK	1.68060200
18	MAP3K2	1.58870950
19	STK38L	1.57916790
20	MAPK11	1.56323263
21	MST1R	1.53582968
22	PDPK1	1.52461507
23	IRAK3	1.47785096
24	TBK1	1.41051887
25	PRKCG	1.37477606
26	NTRK3	1.35619786
27	FGFR2	1.32869183
28	PRPF4B	1.23318435
29	MAP2K4	1.21279330
30	LATS2	1.20568335
31	IGF1R	1.10329817
32	TGFBR2	1.08832181
33	ABL2	1.07804994
34	ERBB2	1.01583486
35	CDK12	1.00932997
36	EPHA2	1.00234215
37	MYLK	0.98096401
38	NLK	0.97628418
39	EPHA3	0.95940917
40	EIF2AK1	0.95165407
41	PRKCZ	0.94007946
42	PKN2	0.93413869
43	PDK1	0.92968894
44	RET	0.91935447
45	STK38	0.90968658
46	EPHA4	0.86562722
47	WNK4	0.86471110
48	MAP2K3	0.85655027
49	DYRK1B	0.84139234
50	MAP3K1	0.82022794
51	JAK1	0.81070355
52	KSR2	0.80997231
53	PDGFRA	0.80845155
54	FGFR1	0.80441001
55	CSNK1D	0.79249645
56	MAP3K11	0.77832950
57	MAPKAPK3	0.77526129
58	LMTK2	0.74779675
59	PRKAA1	0.73974410
60	PDK2	0.72631923
61	MAP3K5	0.70917292
62	SGK223	0.70340139
63	SGK494	0.70340139
64	PRKG1	0.69464176
65	PRKACA	0.69144887
66	TAOK2	0.68743899
67	SGK1	0.68434054
68	JAK2	0.62421258
69	PINK1	0.61220745
70	CSF1R	0.61209179
71	ACVR1B	0.59483271
72	SCYL2	0.56895279
73	AKT3	0.55797512
74	SGK3	0.53432783
75	MAP2K2	0.52742125
76	CDK6	0.52600529
77	RPS6KA3	0.51271405
78	TAOK3	0.50256966
79	MET	0.50074768
80	FER	0.49180420
81	PRKCB	0.48860167
82	INSRR	0.48280234
83	PTK6	0.48208444
84	ARAF	0.47764151
85	SGK2	0.47255555
86	PRKCA	0.46031609
87	CSNK1E	0.45709625
88	SRC	0.43726170
89	ERBB4	0.43131285
90	CAMK1D	0.42667625
91	BCR	0.41650207
92	DAPK2	0.38480702
93	GSK3A	0.38079876
94	ZAP70	0.36295997
95	CAMKK1	0.36120220
96	CSNK2A1	0.35875283
97	CDK4	0.35697484
98	STK16	0.35508433
99	MAP3K7	0.35085242
100	RPS6KB1	0.35030188

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.09338293
2	Caffeine metabolism_Homo sapiens_hsa00232	4.05572049
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.03254175
4	Complement and coagulation cascades_Homo sapiens_hsa04610	3.83365472
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.55897018
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.31303066
7	Retinol metabolism_Homo sapiens_hsa00830	3.28348811
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.88043425
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.84844976
10	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.84251976
11	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.77869195
12	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.70745178
13	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.58029700
14	Arginine biosynthesis_Homo sapiens_hsa00220	2.48637617
15	Phenylalanine metabolism_Homo sapiens_hsa00360	2.47554554
16	Fatty acid degradation_Homo sapiens_hsa00071	2.34131020
17	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.23212703
18	Tyrosine metabolism_Homo sapiens_hsa00350	2.06207632
19	Butanoate metabolism_Homo sapiens_hsa00650	2.02956715
20	Bile secretion_Homo sapiens_hsa04976	1.86880003
21	Histidine metabolism_Homo sapiens_hsa00340	1.79809939
22	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.78334357
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.78324823
24	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.62292220
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.60657957
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.54339737
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.53189831
28	Peroxisome_Homo sapiens_hsa04146	1.43739495
29	PPAR signaling pathway_Homo sapiens_hsa03320	1.41716637
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.41081208
31	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.34795274
32	beta-Alanine metabolism_Homo sapiens_hsa00410	1.26436034
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24755603
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.24402448
35	Fat digestion and absorption_Homo sapiens_hsa04975	1.19785358
36	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.12270693
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12107534
38	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.10528887
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.10523888
40	Pyruvate metabolism_Homo sapiens_hsa00620	1.09606157
41	Arginine and proline metabolism_Homo sapiens_hsa00330	1.06909685
42	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.04851555
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97641178
44	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.97365998
45	Propanoate metabolism_Homo sapiens_hsa00640	0.93124370
46	Fatty acid metabolism_Homo sapiens_hsa01212	0.89989591
47	Carbon metabolism_Homo sapiens_hsa01200	0.89295244
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.84980646
49	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.84038830
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.81093135
51	Prion diseases_Homo sapiens_hsa05020	0.80486685
52	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.78120720
53	ABC transporters_Homo sapiens_hsa02010	0.69750068
54	Sulfur metabolism_Homo sapiens_hsa00920	0.69629227
55	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.69145047
56	One carbon pool by folate_Homo sapiens_hsa00670	0.68784658
57	Sulfur relay system_Homo sapiens_hsa04122	0.60609456
58	Lysine degradation_Homo sapiens_hsa00310	0.56122988
59	Steroid biosynthesis_Homo sapiens_hsa00100	0.47863652
60	Metabolic pathways_Homo sapiens_hsa01100	0.44364150
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40698642
62	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.38309003
63	Fatty acid elongation_Homo sapiens_hsa00062	0.36411040
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36213136
65	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.29430458
66	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.29249225
67	Pertussis_Homo sapiens_hsa05133	0.26768145
68	Other glycan degradation_Homo sapiens_hsa00511	0.22480480
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.20347937
70	Pentose phosphate pathway_Homo sapiens_hsa00030	0.18869443
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.18130424
72	Insulin resistance_Homo sapiens_hsa04931	0.18006087
73	Glutathione metabolism_Homo sapiens_hsa00480	0.16629508
74	Renin-angiotensin system_Homo sapiens_hsa04614	0.14560323
75	Galactose metabolism_Homo sapiens_hsa00052	0.10361694
76	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.10301432
77	Glucagon signaling pathway_Homo sapiens_hsa04922	0.07809713
78	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.03990657
79	Folate biosynthesis_Homo sapiens_hsa00790	0.02759772
80	Selenocompound metabolism_Homo sapiens_hsa00450	0.02513492
81	Ether lipid metabolism_Homo sapiens_hsa00565	-0.2160707
82	Type II diabetes mellitus_Homo sapiens_hsa04930	-0.2037623
83	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1731463
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1617999
85	Nitrogen metabolism_Homo sapiens_hsa00910	-0.1519885
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.1431381
87	Amoebiasis_Homo sapiens_hsa05146	-0.1312462
88	Protein digestion and absorption_Homo sapiens_hsa04974	-0.1238789
89	African trypanosomiasis_Homo sapiens_hsa05143	-0.1163818
90	Pancreatic secretion_Homo sapiens_hsa04972	-0.1081681
91	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0997112
92	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.0823318
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	-0.0775788
94	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	-0.0759969
95	Serotonergic synapse_Homo sapiens_hsa04726	-0.0645355
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.0617126
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.0615868
98	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0596614
99	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.0423292
100	Mineral absorption_Homo sapiens_hsa04978	-0.0236950

SERPINA4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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