SERPINA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)9.27243208
2regulation of male gonad development (GO:2000018)8.85178459
3synaptonemal complex assembly (GO:0007130)8.51054179
4male meiosis (GO:0007140)8.41124208
5synaptonemal complex organization (GO:0070193)8.40158823
6negative regulation of fibrinolysis (GO:0051918)8.32949429
7sex differentiation (GO:0007548)8.17226741
8regulation of fibrinolysis (GO:0051917)7.82709226
9regulation of protein activation cascade (GO:2000257)7.49159739
10DNA methylation involved in gamete generation (GO:0043046)7.43307806
11regulation of complement activation (GO:0030449)7.22101272
12regulation of gonadotropin secretion (GO:0032276)7.11882531
13peptidyl-glutamic acid carboxylation (GO:0017187)7.02138520
14protein carboxylation (GO:0018214)7.02138520
15very-low-density lipoprotein particle assembly (GO:0034379)6.55738474
16male sex determination (GO:0030238)6.34697699
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.31186203
18L-phenylalanine catabolic process (GO:0006559)6.31186203
19plasma lipoprotein particle assembly (GO:0034377)6.15130804
20regulation of cholesterol esterification (GO:0010872)6.08159054
21complement activation, alternative pathway (GO:0006957)6.06894515
22blood coagulation, intrinsic pathway (GO:0007597)5.98411051
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.94221311
24L-phenylalanine metabolic process (GO:0006558)5.94221311
25male meiosis I (GO:0007141)5.93633142
26cilium or flagellum-dependent cell motility (GO:0001539)5.91505170
27oocyte development (GO:0048599)5.79653242
28intestinal cholesterol absorption (GO:0030299)5.75915176
29protein-lipid complex remodeling (GO:0034368)5.72327851
30macromolecular complex remodeling (GO:0034367)5.72327851
31plasma lipoprotein particle remodeling (GO:0034369)5.72327851
32cholesterol efflux (GO:0033344)5.71644165
33negative regulation of cholesterol transport (GO:0032375)5.68224560
34negative regulation of sterol transport (GO:0032372)5.68224560
35anatomical structure regression (GO:0060033)5.63289100
36high-density lipoprotein particle remodeling (GO:0034375)5.54353324
37regulation of plasminogen activation (GO:0010755)5.51061432
38protein-lipid complex assembly (GO:0065005)5.49751673
39spermatid development (GO:0007286)5.42039035
40chromosome organization involved in meiosis (GO:0070192)5.39327711
41triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.36860544
42low-density lipoprotein particle remodeling (GO:0034374)5.36547027
43fibrinolysis (GO:0042730)5.32807292
44* fusion of sperm to egg plasma membrane (GO:0007342)5.25900763
45regulation of apoptotic cell clearance (GO:2000425)5.22208895
46Leydig cell differentiation (GO:0033327)5.21533052
47meiotic nuclear division (GO:0007126)5.20104087
48poly(A)+ mRNA export from nucleus (GO:0016973)5.19773080
49reverse cholesterol transport (GO:0043691)5.11146980
50phospholipid efflux (GO:0033700)5.07291286
51plasma lipoprotein particle clearance (GO:0034381)5.03098545
52sperm motility (GO:0030317)5.01372772
53plasma lipoprotein particle organization (GO:0071827)4.99586102
54negative regulation of macrophage differentiation (GO:0045650)4.91246200
55seminiferous tubule development (GO:0072520)4.87726918
56glomerular basement membrane development (GO:0032836)4.86385028
57negative regulation of protein activation cascade (GO:2000258)4.80983907
58protein-lipid complex subunit organization (GO:0071825)4.70927468
59meiosis I (GO:0007127)4.67959544
60ethanol oxidation (GO:0006069)4.63169604
61macroautophagy (GO:0016236)4.57867877
62glyoxylate metabolic process (GO:0046487)4.56822374
63androgen biosynthetic process (GO:0006702)4.49181242
64regulation of female gonad development (GO:2000194)4.46452793
65negative regulation of blood coagulation (GO:0030195)4.45242577
66negative regulation of hemostasis (GO:1900047)4.45242577
67gene silencing by RNA (GO:0031047)4.44461742
68germ cell development (GO:0007281)4.41196439
69acrosome assembly (GO:0001675)4.33790626
70positive regulation of meiosis (GO:0045836)4.30597423
71negative regulation of meiosis (GO:0045835)4.28063433
72protein activation cascade (GO:0072376)4.26089591
73positive regulation of hemostasis (GO:1900048)4.25861514
74positive regulation of blood coagulation (GO:0030194)4.25861514
75ovulation cycle (GO:0042698)4.25689490
76epoxygenase P450 pathway (GO:0019373)4.25647616
77sperm-egg recognition (GO:0035036)4.23135446
78regulation of humoral immune response (GO:0002920)4.23095016
79response to misfolded protein (GO:0051788)4.21092189
80hemoglobin metabolic process (GO:0020027)4.20782231
81astrocyte development (GO:0014002)4.17774510
82regulation of bile acid biosynthetic process (GO:0070857)4.17184194
83negative regulation of coagulation (GO:0050819)4.11950640
84acylglycerol homeostasis (GO:0055090)4.10602808
85triglyceride homeostasis (GO:0070328)4.10602808
86multicellular organism reproduction (GO:0032504)4.10188143
87acute-phase response (GO:0006953)4.10150812
88negative regulation of lipase activity (GO:0060192)4.04268357
89axonemal dynein complex assembly (GO:0070286)4.02079191
90binding of sperm to zona pellucida (GO:0007339)4.01666544
91positive regulation of meiotic cell cycle (GO:0051446)4.00892334
92aromatic amino acid family catabolic process (GO:0009074)3.99915771
93* cellular process involved in reproduction in multicellular organism (GO:0022412)3.97880687
94negative regulation of complement activation (GO:0045916)3.97139640
95drug catabolic process (GO:0042737)3.95601944
96complement activation, classical pathway (GO:0006958)3.95463163
97exogenous drug catabolic process (GO:0042738)3.94064787
98negative regulation of wound healing (GO:0061045)3.93260647
99positive regulation of lipoprotein lipase activity (GO:0051006)3.92940616
100positive regulation of triglyceride lipase activity (GO:0061365)3.92940616
101positive regulation of coagulation (GO:0050820)3.92031684
102positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.88195977
103urea metabolic process (GO:0019627)3.84130062
104regulation of cholesterol homeostasis (GO:2000188)3.83500842
105regulation of cholesterol biosynthetic process (GO:0045540)3.83224980
106cholesterol transport (GO:0030301)3.82388069
107sterol transport (GO:0015918)3.82388069
108ethanol metabolic process (GO:0006067)3.79366587
109lipoprotein metabolic process (GO:0042157)3.77098275
110cholesterol homeostasis (GO:0042632)3.74133264
111* spermatogenesis (GO:0007283)3.71392181
112cell-cell recognition (GO:0009988)3.71218083
113glutamate metabolic process (GO:0006536)3.70875899
114genitalia morphogenesis (GO:0035112)3.70267765
115* male gamete generation (GO:0048232)3.70104645
116sterol homeostasis (GO:0055092)3.69294616
117positive regulation of steroid metabolic process (GO:0045940)3.68343987
118* plasma membrane fusion (GO:0045026)3.68163531
119intestinal absorption (GO:0050892)3.68103097
120epithelial cilium movement (GO:0003351)3.66641482
121positive regulation of reproductive process (GO:2000243)3.66535009
122bile acid metabolic process (GO:0008206)3.64619258
123positive regulation of extracellular matrix organization (GO:1903055)3.63713713
124positive regulation of fatty acid biosynthetic process (GO:0045723)3.57386841
125serine family amino acid catabolic process (GO:0009071)3.56386189
126complement activation (GO:0006956)3.54421248
127regulation of protein polyubiquitination (GO:1902914)3.53486582
128acrosome reaction (GO:0007340)3.52540590
129proline metabolic process (GO:0006560)3.51896707
130omega-hydroxylase P450 pathway (GO:0097267)3.50602679
131urea cycle (GO:0000050)3.50022509
132response to mercury ion (GO:0046689)3.48019382
133cellular glucuronidation (GO:0052695)3.47348185
134bile acid biosynthetic process (GO:0006699)3.45501780
135cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.43465761
136nitrogen cycle metabolic process (GO:0071941)3.43122029
137apoptotic cell clearance (GO:0043277)3.41740652
138glial cell proliferation (GO:0014009)3.41426925
139* gamete generation (GO:0007276)3.40579670
140cytolysis (GO:0019835)3.34613577
141motile cilium assembly (GO:0044458)3.33803866
142DNA alkylation (GO:0006305)3.32139898
143DNA methylation (GO:0006306)3.32139898
144epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.31560198
145female gamete generation (GO:0007292)3.30669463
146regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.29532649
147regulation of triglyceride catabolic process (GO:0010896)3.29403330
148imidazole-containing compound metabolic process (GO:0052803)3.28813831
149meiotic cell cycle (GO:0051321)3.28575851
150reproduction (GO:0000003)3.28169038
151oogenesis (GO:0048477)3.26136903
152gene silencing (GO:0016458)3.26136383
153glucuronate metabolic process (GO:0019585)3.25810746
154uronic acid metabolic process (GO:0006063)3.25810746
155negative regulation of lipid transport (GO:0032369)3.22849352
156tyrosine metabolic process (GO:0006570)3.21930214
157positive regulation of hormone metabolic process (GO:0032352)3.20796123
158meiotic cell cycle process (GO:1903046)3.20634896
159regulation of cholesterol metabolic process (GO:0090181)3.17626306
160glycine metabolic process (GO:0006544)3.16588861
161Sertoli cell development (GO:0060009)3.15641205
162fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.15626838
163low-density lipoprotein particle clearance (GO:0034383)3.13329448
164fertilization (GO:0009566)3.09868129
165cellular response to gonadotropin stimulus (GO:0071371)3.08491874
166cilium movement (GO:0003341)3.07667546
167drug transmembrane transport (GO:0006855)3.06625626
168estrogen biosynthetic process (GO:0006703)3.06413995
169nuclear pore complex assembly (GO:0051292)3.06134751
170germ cell migration (GO:0008354)3.05050446
171chaperone-mediated protein complex assembly (GO:0051131)3.04863119
172histone H4-K8 acetylation (GO:0043982)3.00486720
173histone H4-K5 acetylation (GO:0043981)3.00486720
174embryonic foregut morphogenesis (GO:0048617)2.99600607
175regulation of microtubule-based movement (GO:0060632)2.99368311
176negative regulation of DNA repair (GO:0045738)2.96429632
177receptor guanylyl cyclase signaling pathway (GO:0007168)2.94181995
178cellular response to interferon-alpha (GO:0035457)2.93383823
179regulation of nucleobase-containing compound transport (GO:0032239)2.91899739
180regulation of inclusion body assembly (GO:0090083)2.90908259
181peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.87022442
182negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.85143534
183alpha-linolenic acid metabolic process (GO:0036109)2.82986990
184male genitalia development (GO:0030539)2.82600496
185* multicellular organismal reproductive process (GO:0048609)2.76382193
186single fertilization (GO:0007338)2.76234653
187ovulation cycle process (GO:0022602)2.70271764
188regulation of cilium movement (GO:0003352)2.70183605
189peptidyl-lysine dimethylation (GO:0018027)2.66866892
190diaphragm development (GO:0060539)2.66430476
191male gonad development (GO:0008584)2.65386219
192adrenal gland development (GO:0030325)2.65192390
193response to follicle-stimulating hormone (GO:0032354)2.63578483
194gonadal mesoderm development (GO:0007506)14.8869658
195piRNA metabolic process (GO:0034587)11.0350396
196positive regulation of male gonad development (GO:2000020)10.2198311
197sex determination (GO:0007530)10.0131702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human8.11678865
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.56268599
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.68654049
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.02782141
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.86487268
6NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85400806
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.77986958
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.65412512
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.48847712
10* HNF4A_19822575_ChIP-Seq_HepG2_Human2.95820747
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.84831731
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76167890
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.74871362
14ZNF263_19887448_ChIP-Seq_K562_Human2.55913317
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41681375
16ESR1_15608294_ChIP-ChIP_MCF-7_Human2.18483324
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.13013916
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08204469
19CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.06153031
20CLOCK_20551151_ChIP-Seq_293T_Human2.05305395
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.96420935
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.83552067
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.83552067
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.83552067
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.80649916
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79683368
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.77127658
28TCF7_22412390_ChIP-Seq_EML_Mouse1.69900370
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68046032
30GATA4_25053715_ChIP-Seq_YYC3_Human1.67555923
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.64633031
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63636677
33CDX2_20551321_ChIP-Seq_CACO-2_Human1.62458676
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59840290
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.57910534
36TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54086593
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46277342
38RNF2_27304074_Chip-Seq_NSC_Mouse1.46208493
39KDM2B_26808549_Chip-Seq_DND41_Human1.45743745
40TP53_22127205_ChIP-Seq_IMR90_Human1.45029748
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40995325
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40824226
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.39415045
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39208876
45CREB1_26743006_Chip-Seq_LNCaP_Human1.38904691
46TCF4_18268006_ChIP-ChIP_LS174T_Human1.38216454
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38074903
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37350349
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37203594
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.35729643
51GATA6_25053715_ChIP-Seq_YYC3_Human1.33965272
52OCT4_19829295_ChIP-Seq_ESCs_Human1.33700391
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32854082
54TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.30258896
55EZH2_22144423_ChIP-Seq_EOC_Human1.29857145
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29249673
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29108403
58KDM2B_26808549_Chip-Seq_K562_Human1.28111896
59ZNF274_21170338_ChIP-Seq_K562_Hela1.24375815
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23550313
61FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21300497
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19612420
63ESR1_21235772_ChIP-Seq_MCF-7_Human1.19576450
64* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17781804
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17357932
66* FOXA2_19822575_ChIP-Seq_HepG2_Human1.15997181
67ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15798843
68NCOR1_26117541_ChIP-Seq_K562_Human1.14293222
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.14293171
70* LXR_22158963_ChIP-Seq_LIVER_Mouse1.12940600
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.12750181
72BCAT_22108803_ChIP-Seq_LS180_Human1.12121474
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12026655
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11799618
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09910719
76EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09456494
77* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09204475
78CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08582151
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07257030
80SOX2_20726797_ChIP-Seq_SW620_Human1.06076265
81GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.05917403
82MYC_27129775_Chip-Seq_CORNEA_Mouse1.04810653
83SOX2_21211035_ChIP-Seq_LN229_Human1.04143226
84RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04093672
85TBX20_22080862_ChIP-Seq_HEART_Mouse1.02346529
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.02346529
87SOX11_22085726_ChIP-Seq_ESNs_Mouse1.02074741
88SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01745956
89RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01539300
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01260255
91* SMAD4_21741376_ChIP-Seq_EPCs_Human1.00747521
92CTCF_27219007_Chip-Seq_Bcells_Human1.00632289
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99962786
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99747931
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96915527
96SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.96483533
97CHD1_26751641_Chip-Seq_LNCaP_Human0.96358418
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96287516
99WDR5_24793694_ChIP-Seq_LNCAP_Human0.96218409
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95629930
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95583607
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95536382
103LXR_22292898_ChIP-Seq_THP-1_Human0.95393993
104STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94427925
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94007644
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.92531305
107PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92467847
108POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91074513
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90736689
110GATA3_26560356_Chip-Seq_TH1_Human0.90680741
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.89688996
112SMC4_20622854_ChIP-Seq_HELA_Human0.89520745
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.89374424
114* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89009203
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88639071
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88414318
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88029256
118CBX2_27304074_Chip-Seq_ESCs_Mouse0.87688263
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87621794
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85936052
121RACK7_27058665_Chip-Seq_MCF-7_Human0.85365162
122KLF4_19829295_ChIP-Seq_ESCs_Human0.84595523
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.83713175
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83237147
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82686042
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82614001
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82387839
128PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82383032
129ISL1_27105846_Chip-Seq_CPCs_Mouse0.82314781
130SA1_27219007_Chip-Seq_ERYTHROID_Human0.81991362
131* RXR_22158963_ChIP-Seq_LIVER_Mouse0.80982338
132FOXH1_21741376_ChIP-Seq_ESCs_Human0.79982486
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.79677175
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79572505
135* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79034985
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78603531
137KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78128192
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77636122
139P53_21459846_ChIP-Seq_SAOS-2_Human0.77489674
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.77118728
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76745670
142CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76632348
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.76556257
144KDM2B_26808549_Chip-Seq_SUP-B15_Human0.76260144
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.74767801
146AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74589974
147RARA_24833708_ChIP-Seq_LIVER_Mouse0.73682039
148SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73365330
149AR_21909140_ChIP-Seq_LNCAP_Human0.72497228
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.71357896
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.70886111
152SMAD1_18555785_Chip-Seq_ESCs_Mouse0.69413885
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.69119202
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68687791
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67798704
156SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.66919733
157STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.64284070
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.63832154
159RARB_24833708_ChIP-Seq_LIVER_Mouse0.62876529
160PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60202348
161SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.59279596
162ZNF217_24962896_ChIP-Seq_MCF-7_Human0.59225556
163SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.59155289
164ZFX_18555785_Chip-Seq_ESCs_Mouse0.57912994
165DNAJC2_21179169_ChIP-ChIP_NT2_Human0.57574312
166RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56272508
167ESRRB_18555785_Chip-Seq_ESCs_Mouse0.56066205
168RAC3_21632823_ChIP-Seq_H3396_Human0.54345978
169NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.54153330
170EOMES_21245162_ChIP-Seq_HESCs_Human0.54048221
171PCGF2_27294783_Chip-Seq_ESCs_Mouse0.53964381
172* CEBPB_22108803_ChIP-Seq_LS180_Human0.53050871
173NANOG_21062744_ChIP-ChIP_HESCs_Human0.52588726
174EP300_21415370_ChIP-Seq_HL-1_Mouse0.51825932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence7.80044460
2MP0008877_abnormal_DNA_methylation6.77697278
3MP0005360_urolithiasis5.46818917
4MP0003878_abnormal_ear_physiology5.40479544
5MP0005377_hearing/vestibular/ear_phenot5.40479544
6* MP0005410_abnormal_fertilization4.85714078
7MP0005085_abnormal_gallbladder_physiolo4.58388278
8MP0008875_abnormal_xenobiotic_pharmacok4.25423638
9MP0003195_calcinosis4.12161347
10MP0001666_abnormal_nutrient_absorption3.68834593
11MP0003122_maternal_imprinting3.54106657
12MP0002210_abnormal_sex_determination3.22091659
13* MP0001929_abnormal_gametogenesis3.16220944
14MP0003786_premature_aging3.13249682
15MP0005647_abnormal_sex_gland3.12508877
16MP0001661_extended_life_span3.10614298
17* MP0003698_abnormal_male_reproductive2.98115940
18MP0003252_abnormal_bile_duct2.91159430
19MP0009840_abnormal_foam_cell2.81386494
20MP0003868_abnormal_feces_composition2.71719571
21* MP0001145_abnormal_male_reproductive2.65072157
22MP0003879_abnormal_hair_cell2.33405532
23MP0002138_abnormal_hepatobiliary_system2.32566966
24MP0003045_fibrosis2.28749748
25* MP0000653_abnormal_sex_gland2.24571604
26MP0001727_abnormal_embryo_implantation2.12911323
27MP0010368_abnormal_lymphatic_system2.09735738
28MP0003315_abnormal_perineum_morphology2.06143684
29MP0005332_abnormal_amino_acid2.05287344
30MP0009384_cardiac_valve_regurgitation1.99998566
31MP0002160_abnormal_reproductive_system1.86160331
32MP0000566_synostosis1.85128104
33MP0002089_abnormal_postnatal_growth/wei1.82628459
34MP0005623_abnormal_meninges_morphology1.82196165
35MP0000609_abnormal_liver_physiology1.76468312
36MP0002102_abnormal_ear_morphology1.71262041
37MP0002132_abnormal_respiratory_system1.69861217
38MP0005058_abnormal_lysosome_morphology1.68988238
39MP0002118_abnormal_lipid_homeostasis1.67715194
40* MP0002161_abnormal_fertility/fecundity1.62439316
41MP0002168_other_aberrant_phenotype1.62408325
42MP0009278_abnormal_bone_marrow1.61414810
43MP0001915_intracranial_hemorrhage1.55458834
44MP0005451_abnormal_body_composition1.52175189
45MP0004019_abnormal_vitamin_homeostasis1.48801190
46MP0003936_abnormal_reproductive_system1.44234502
47MP0004272_abnormal_basement_membrane1.43510217
48MP0009697_abnormal_copulation1.42389555
49MP0002139_abnormal_hepatobiliary_system1.41501480
50MP0002876_abnormal_thyroid_physiology1.37252228
51MP0003191_abnormal_cellular_cholesterol1.37033276
52MP0001764_abnormal_homeostasis1.34939681
53MP0001958_emphysema1.34724533
54MP0000751_myopathy1.34619460
55MP0005389_reproductive_system_phenotype1.34271558
56MP0000639_abnormal_adrenal_gland1.31019872
57MP0000569_abnormal_digit_pigmentation1.29064508
58MP0004147_increased_porphyrin_level1.27913940
59MP0003115_abnormal_respiratory_system1.24688927
60MP0004742_abnormal_vestibular_system1.21558504
61MP0004084_abnormal_cardiac_muscle1.21278311
62MP0003121_genomic_imprinting1.18325018
63MP0000598_abnormal_liver_morphology1.15050911
64MP0003567_abnormal_fetal_cardiomyocyte1.12497473
65MP0005319_abnormal_enzyme/_coenzyme1.09279216
66MP0002653_abnormal_ependyma_morphology1.08752020
67MP0005076_abnormal_cell_differentiation1.08438414
68MP0002909_abnormal_adrenal_gland1.07939599
69MP0003172_abnormal_lysosome_physiology1.05821773
70MP0006138_congestive_heart_failure1.05621298
71MP0005636_abnormal_mineral_homeostasis1.02650819
72MP0001440_abnormal_grooming_behavior1.00125953
73MP0003123_paternal_imprinting1.00089540
74MP0000537_abnormal_urethra_morphology0.97281226
75MP0009643_abnormal_urine_homeostasis0.96044588
76MP0003011_delayed_dark_adaptation0.94921906
77MP0001119_abnormal_female_reproductive0.93126228
78MP0005220_abnormal_exocrine_pancreas0.92650102
79MP0009642_abnormal_blood_homeostasis0.86649840
80MP0004036_abnormal_muscle_relaxation0.86438584
81MP0003300_gastrointestinal_ulcer0.85093843
82MP0005395_other_phenotype0.83669937
83MP0003941_abnormal_skin_development0.83111827
84MP0003866_abnormal_defecation0.82803117
85MP0008057_abnormal_DNA_replication0.82689453
86MP0000427_abnormal_hair_cycle0.81906493
87MP0005257_abnormal_intraocular_pressure0.81669977
88MP0003806_abnormal_nucleotide_metabolis0.81117345
89MP0004885_abnormal_endolymph0.80899702
90MP0005409_darkened_coat_color0.79562652
91MP0008438_abnormal_cutaneous_collagen0.79535597
92MP0009780_abnormal_chondrocyte_physiolo0.78777602
93MP0001919_abnormal_reproductive_system0.78746925
94MP0003943_abnormal_hepatobiliary_system0.78375345
95MP0003942_abnormal_urinary_system0.77811903
96MP0003656_abnormal_erythrocyte_physiolo0.76627679
97MP0003699_abnormal_female_reproductive0.75533551
98MP0005670_abnormal_white_adipose0.74511927
99MP0001851_eye_inflammation0.73574917
100MP0004233_abnormal_muscle_weight0.72787805
101MP0008961_abnormal_basal_metabolism0.69699845
102MP0005167_abnormal_blood-brain_barrier0.67769212
103MP0005584_abnormal_enzyme/coenzyme_acti0.66041356
104MP0005464_abnormal_platelet_physiology0.65942714
105MP0002295_abnormal_pulmonary_circulatio0.65362071
106MP0002971_abnormal_brown_adipose0.64522340
107MP0004134_abnormal_chest_morphology0.64253033
108MP0005248_abnormal_Harderian_gland0.63933488
109MP0002078_abnormal_glucose_homeostasis0.63241745
110MP0004197_abnormal_fetal_growth/weight/0.63067214
111MP0001756_abnormal_urination0.61222318
112MP0005376_homeostasis/metabolism_phenot0.60513209
113MP0005408_hypopigmentation0.58516280
114MP0003119_abnormal_digestive_system0.58379388
115MP0005084_abnormal_gallbladder_morpholo0.58004598
116MP0005164_abnormal_response_to0.56318900
117MP0004883_abnormal_blood_vessel0.56162078
118MP0005379_endocrine/exocrine_gland_phen0.54812187
119MP0003329_amyloid_beta_deposits0.54614292
120MP0002282_abnormal_trachea_morphology0.54477134
121MP0003091_abnormal_cell_migration0.53607241
122MP0003283_abnormal_digestive_organ0.53028981
123MP0002933_joint_inflammation0.52994202
124MP0004264_abnormal_extraembryonic_tissu0.51575897
125MP0004043_abnormal_pH_regulation0.51539099
126MP0008469_abnormal_protein_level0.51125210
127MP0003566_abnormal_cell_adhesion0.50838337
128MP0003705_abnormal_hypodermis_morpholog0.50474550
129MP0005503_abnormal_tendon_morphology0.50082011
130MP0001270_distended_abdomen0.50027795
131MP0000003_abnormal_adipose_tissue0.49185708
132MP0001730_embryonic_growth_arrest0.47725238
133MP0000470_abnormal_stomach_morphology0.46650940
134MP0005187_abnormal_penis_morphology0.46598061
135MP0000767_abnormal_smooth_muscle0.46058948
136MP0000631_abnormal_neuroendocrine_gland0.45826801
137MP0003950_abnormal_plasma_membrane0.44133381
138MP0005448_abnormal_energy_balance0.42439250
139MP0002896_abnormal_bone_mineralization0.42338620
140MP0010307_abnormal_tumor_latency0.42314965
141MP0003183_abnormal_peptide_metabolism0.41630967
142MP0002090_abnormal_vision0.40065671
143MP0005646_abnormal_pituitary_gland0.39930093
144MP0002092_abnormal_eye_morphology0.39885816
145MP0005023_abnormal_wound_healing0.39410021
146MP0002128_abnormal_blood_circulation0.39106402
147MP0003638_abnormal_response/metabolism_0.38887201
148MP0002084_abnormal_developmental_patter0.38792350
149MP0002269_muscular_atrophy0.38587201
150MP0001340_abnormal_eyelid_morphology0.37403440
151MP0006054_spinal_hemorrhage0.37367611
152MP0009672_abnormal_birth_weight0.37169941
153MP0005397_hematopoietic_system_phenotyp0.36885282
154MP0001545_abnormal_hematopoietic_system0.36885282
155MP0003953_abnormal_hormone_level0.36764224
156MP0005365_abnormal_bile_salt0.36613664
157MP0003632_abnormal_nervous_system0.36340604
158MP0004145_abnormal_muscle_electrophysio0.35004480
159MP0000383_abnormal_hair_follicle0.34894523
160MP0000604_amyloidosis0.34696562
161MP0000428_abnormal_craniofacial_morphol0.34413374
162MP0009703_decreased_birth_body0.33743589
163MP0003690_abnormal_glial_cell0.33159323
164MP0010329_abnormal_lipoprotein_level0.32161881
165MP0010678_abnormal_skin_adnexa0.30947902
166MP0005666_abnormal_adipose_tissue0.30899752

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)9.46924921
2Gonadotropin excess (HP:0000837)9.20803912
3Prolonged partial thromboplastin time (HP:0003645)8.03230577
4Complement deficiency (HP:0004431)7.22321346
5Hypobetalipoproteinemia (HP:0003563)6.45345577
6Joint hemorrhage (HP:0005261)6.34072122
7Abnormal sex determination (HP:0012244)6.22245219
8Sex reversal (HP:0012245)6.22245219
9Male pseudohermaphroditism (HP:0000037)6.01289642
10Infertility (HP:0000789)5.83342278
11Abnormality of monocarboxylic acid metabolism (HP:0010996)5.77369734
12Azoospermia (HP:0000027)5.76870282
13Abnormality of aromatic amino acid family metabolism (HP:0004338)5.75762747
14Abnormality of complement system (HP:0005339)5.50389869
15Testicular neoplasm (HP:0010788)5.43826242
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.22575865
17Abnormality of the common coagulation pathway (HP:0010990)5.10978342
18Absent/shortened dynein arms (HP:0200106)5.06151903
19Dynein arm defect of respiratory motile cilia (HP:0012255)5.06151903
20Glomerulonephritis (HP:0000099)5.02623750
21Xanthomatosis (HP:0000991)4.93824159
22Abnormal spermatogenesis (HP:0008669)4.92094303
23Systemic lupus erythematosus (HP:0002725)4.83789870
24Abnormality of male internal genitalia (HP:0000022)4.63140976
25Hand muscle atrophy (HP:0009130)4.52101418
2611 pairs of ribs (HP:0000878)4.45773718
27Facial diplegia (HP:0001349)4.18501185
28Hypolipoproteinemia (HP:0010981)4.17481629
29Abnormality of the lower motor neuron (HP:0002366)4.08815115
30Hypercholesterolemia (HP:0003124)3.80437400
31Ankle clonus (HP:0011448)3.64049204
32Upper limb amyotrophy (HP:0009129)3.57122536
33Distal upper limb amyotrophy (HP:0007149)3.57122536
34Hypoplasia of the uterus (HP:0000013)3.52222363
35Hemorrhage of the eye (HP:0011885)3.46732428
36Metaphyseal cupping (HP:0003021)3.46691686
37Menorrhagia (HP:0000132)3.40041507
38Tongue fasciculations (HP:0001308)3.37818120
39Secondary amenorrhea (HP:0000869)3.33780807
40Abnormal respiratory motile cilium physiology (HP:0012261)3.33465568
41Germ cell neoplasia (HP:0100728)3.31000815
42Vascular calcification (HP:0004934)3.28388860
43Abnormality of carpal bone ossification (HP:0006257)3.26050402
44Mitral stenosis (HP:0001718)3.24869090
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.23646153
46Stridor (HP:0010307)3.22329227
47Hyperlipoproteinemia (HP:0010980)3.22205767
48Mesangial abnormality (HP:0001966)3.19999392
49Conjugated hyperbilirubinemia (HP:0002908)3.19828458
50Intrahepatic cholestasis (HP:0001406)3.17946461
51Epidermoid cyst (HP:0200040)3.12848871
52Abnormal respiratory epithelium morphology (HP:0012253)3.08556096
53Abnormal respiratory motile cilium morphology (HP:0005938)3.08556096
54Muscle fibrillation (HP:0010546)3.05506620
55Recurrent gram-negative bacterial infections (HP:0005420)3.04680599
56Diaphragmatic weakness (HP:0009113)3.01679616
57Osteomalacia (HP:0002749)3.00730175
58Hypoalphalipoproteinemia (HP:0003233)3.00123213
59Rectal prolapse (HP:0002035)2.97053660
60Rhinitis (HP:0012384)2.96524215
61Cardiovascular calcification (HP:0011915)2.87207629
62Nasal polyposis (HP:0100582)2.81185212
63Abnormality of the intrinsic pathway (HP:0010989)2.80643463
64Ankle contracture (HP:0006466)2.80572993
65Abnormal tarsal ossification (HP:0008369)2.79522989
66Missing ribs (HP:0000921)2.76179293
67Fat malabsorption (HP:0002630)2.75506568
68Gingival bleeding (HP:0000225)2.74122336
69Small epiphyses (HP:0010585)2.68209509
70Hyperglycinemia (HP:0002154)2.66754538
71Arthropathy (HP:0003040)2.65145005
72Purpura (HP:0000979)2.63103504
73Chronic bronchitis (HP:0004469)2.61933532
74Acanthocytosis (HP:0001927)2.56809480
75Flat acetabular roof (HP:0003180)2.55830974
76Rickets (HP:0002748)2.53381719
77Hyperpituitarism (HP:0010514)2.51996162
78Clumsiness (HP:0002312)2.50328849
79Pulmonary fibrosis (HP:0002206)2.48466114
80Nausea (HP:0002018)2.47997252
81Fibular hypoplasia (HP:0003038)2.47925595
82Stage 5 chronic kidney disease (HP:0003774)2.47345711
83Primary amenorrhea (HP:0000786)2.46605146
84Clonus (HP:0002169)2.45451497
85Abnormality of the nasal mucosa (HP:0000433)2.44772683
86Hypoventilation (HP:0002791)2.43964405
87Abnormal ciliary motility (HP:0012262)2.43529935
88Abnormal hand bone ossification (HP:0010660)2.43297029
89Polycystic ovaries (HP:0000147)2.41297182
90Abnormal ossification of hand bones (HP:0005921)2.39585643
91Occipital encephalocele (HP:0002085)2.38489408
92Hypophosphatemic rickets (HP:0004912)2.37741303
93Premature ovarian failure (HP:0008209)2.35657869
94Abnormality of the musculature of the hand (HP:0001421)2.35043794
95Abnormality of the vocal cords (HP:0008777)2.33958000
96Hypoplastic left heart (HP:0004383)2.31247868
97Renovascular hypertension (HP:0100817)2.22821227
98Potter facies (HP:0002009)2.22578033
99Facial shape deformation (HP:0011334)2.22578033
100Abnormality of dentin (HP:0010299)2.22401022
101Myopathic facies (HP:0002058)2.22368269
102Thrombophlebitis (HP:0004418)2.18788073
103Bladder diverticulum (HP:0000015)2.18062964
104Skin nodule (HP:0200036)2.17211029
105Aplasia/hypoplasia of the uterus (HP:0008684)2.16252060
106Broad alveolar ridges (HP:0000187)2.14316422
107Abnormality of serine family amino acid metabolism (HP:0010894)2.12914835
108Abnormality of glycine metabolism (HP:0010895)2.12914835
109Myocardial infarction (HP:0001658)2.12116164
110Enlarged kidneys (HP:0000105)2.09205500
111Abnormality of glutamine family amino acid metabolism (HP:0010902)2.08227791
112Hyperglycinuria (HP:0003108)2.07521785
113Amyotrophic lateral sclerosis (HP:0007354)2.07358839
114Broad palm (HP:0001169)2.07344049
115Hepatocellular carcinoma (HP:0001402)2.06803792
116Generalized aminoaciduria (HP:0002909)2.06038716
117Abnormality of pyrimidine metabolism (HP:0004353)2.03140429
118Pancreatic islet-cell hyperplasia (HP:0004510)2.02133389
119Deep venous thrombosis (HP:0002625)10.7544053
120Male infertility (HP:0003251)10.1776555
121Hyperammonemia (HP:0001987)1.99964900
122Nephronophthisis (HP:0000090)1.98838320
123Gout (HP:0001997)1.97061439
124Abnormality of the lumbar spine (HP:0100712)1.94458716
125Abnormality of the nasal septum (HP:0000419)1.93978612
126Asymmetry of the thorax (HP:0001555)1.93711937
127Bifid scrotum (HP:0000048)1.92962713
128Selective tooth agenesis (HP:0001592)1.92058948
129Lymphangioma (HP:0100764)1.89241851
130Abnormality of the Achilles tendon (HP:0005109)1.87758345
131Epiphyseal dysplasia (HP:0002656)1.87454656
132Flared iliac wings (HP:0002869)1.85694207
133Vaginal fistula (HP:0004320)1.84429982
134Hypoglycemic coma (HP:0001325)1.80701835
135Steatorrhea (HP:0002570)1.80437568
136Beaking of vertebral bodies (HP:0004568)1.79274118
137Tubulointerstitial nephritis (HP:0001970)1.79198962
138Increased serum pyruvate (HP:0003542)1.77963350
139Hyporeflexia of lower limbs (HP:0002600)1.77101779
140Glomerulosclerosis (HP:0000096)1.76249359
141Abnormality of the acetabulum (HP:0003170)1.74313062
142Cupped ribs (HP:0000887)1.74181514
143Transposition of the great arteries (HP:0001669)1.74072504
144Abnormal connection of the cardiac segments (HP:0011545)1.74072504
145Abnormal ventriculo-arterial connection (HP:0011563)1.74072504
146Cerebral aneurysm (HP:0004944)1.73772279
147Protrusio acetabuli (HP:0003179)1.73258489
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71587547
149Alacrima (HP:0000522)1.70130113
150Coxa vara (HP:0002812)1.69579502
151Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69337451
152Hepatoblastoma (HP:0002884)1.69067935
153Ovarian neoplasm (HP:0100615)1.68631356
154Focal segmental glomerulosclerosis (HP:0000097)1.67428479
155Abnormal foot bone ossification (HP:0010675)1.67344907
156Abnormality of methionine metabolism (HP:0010901)1.67147993
157Arachnodactyly (HP:0001166)1.66171920
158Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.65975489
159Biconcave vertebral bodies (HP:0004586)1.65078770
160Neonatal death (HP:0003811)1.64110072
161Fasciculations (HP:0002380)1.64018213
162Exercise-induced myalgia (HP:0003738)1.63928431
163Abnormality of the wing of the ilium (HP:0011867)1.63818996
164Bronchitis (HP:0012387)1.63665042
165Hyperacusis (HP:0010780)1.62594272
166Heterotopia (HP:0002282)1.62540878
167Abnormality of the peritoneum (HP:0002585)1.61511455
168Pulmonary embolism (HP:0002204)1.61362269
169Poikilocytosis (HP:0004447)1.60828222
170Neonatal short-limb short stature (HP:0008921)1.60095997
171Bronchiectasis (HP:0002110)1.58845418
172Hypoplasia of the iris (HP:0007676)1.58375158
173Increased variability in muscle fiber diameter (HP:0003557)1.57679304
174Rhizomelia (HP:0008905)1.57632992
175Hypoplastic heart (HP:0001961)1.56699248
176Limb-girdle muscle weakness (HP:0003325)1.54497480
177Spontaneous abortion (HP:0005268)1.54396966
178Oligodactyly (HP:0012165)1.53593555
179Female pseudohermaphroditism (HP:0010458)1.50960209
180Tubular atrophy (HP:0000092)1.48561722
181Abnormality of the calcaneus (HP:0008364)1.46182998
182Abnormality of the renal medulla (HP:0100957)1.44879038
183Insomnia (HP:0100785)1.43984106
184Nephritis (HP:0000123)1.41069021
185Bulbar palsy (HP:0001283)1.40632098
186Back pain (HP:0003418)1.40184013
187Absent frontal sinuses (HP:0002688)1.38540853
188Tubulointerstitial abnormality (HP:0001969)1.38078044
189Aortic aneurysm (HP:0004942)1.37555728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO34.95681858
2PDK34.54677218
3PDK44.54677218
4FGFR34.46269544
5CDK124.31028015
6ICK3.91686477
7PRKD33.91185958
8AKT33.18131581
9TRIB32.92382236
10PDK22.77032938
11WNK42.47390467
12WNK32.42894411
13TESK12.42048998
14PIK3CA2.38337661
15FGFR22.37207823
16RIPK12.18814899
17PTK2B2.10379792
18LATS12.05290473
19BRD41.99855667
20WNK11.98289804
21PTK61.93624172
22MAP3K41.77728049
23CDK71.67329928
24PRKAA21.64910279
25CDK91.60200924
26PNCK1.55899060
27DAPK21.54872067
28SGK2231.50020696
29SGK4941.50020696
30EEF2K1.45498405
31PDPK11.44609909
32EPHB11.43992758
33STK31.36310736
34MYLK1.33009319
35NEK21.32249868
36PKN21.29827245
37MAPK111.28237623
38SGK21.26905694
39PDGFRA1.23827648
40CDK41.22393636
41SGK31.20153710
42NEK91.18069790
43STK391.17105426
44CAMK1G1.16234970
45MTOR1.14973862
46MAP3K101.14061132
47PAK21.12237046
48LMTK21.10651723
49EPHA21.08716056
50TGFBR21.03976957
51PAK41.03579480
52CDC71.03517594
53SGK10.96669504
54ERN10.93717467
55PRKACG0.91334901
56CSNK1A1L0.83701784
57MAPKAPK30.82879087
58PRKAA10.82552553
59SIK20.82223003
60EIF2AK10.81821423
61TNK20.75383207
62MAP2K20.72522596
63MAP3K70.69372281
64NLK0.68603382
65FGR0.67709236
66WEE10.65643239
67PTK20.64883438
68PRPF4B0.62965987
69CAMK1D0.62017216
70RPS6KB10.61931825
71NTRK30.59999953
72BMX0.59936922
73CHEK10.59581362
74MELK0.59045714
75MAP3K10.58725208
76EPHA40.58042106
77PDGFRB0.58040531
78CSNK1E0.57970562
79FGFR10.54067801
80MAP3K30.53566693
81LATS20.53118940
82CDC42BPA0.52756669
83STK380.52750804
84RET0.52170699
85ATR0.51734168
86MAPK150.51686989
87PRKCZ0.51623606
88TAOK20.50322586
89STK38L0.49269911
90TYK20.48837207
91IRAK30.48707902
92PASK0.48678959
93FER0.48140693
94ATM0.47581947
95MAP3K50.47249513
96CSNK1D0.46560299
97MET0.45259519
98DYRK1B0.45037383
99IGF1R0.42830415
100PAK60.42233657
101SCYL20.40916340
102BCR0.40410468
103SIK10.40345461
104PRKCG0.39866404
105CSF1R0.39459246
106PRKACB0.39190792
107MAP2K60.39119768
108SRC0.38452915
109MAP2K40.38149894
110TTN0.37776346
111EGFR0.36967729
112PRKACA0.36938090
113DMPK0.36854484
114DAPK10.36756985
115MAPK10.36742001
116PRKG10.36504658
117OBSCN0.34928126
118MST1R0.34868454
119CDK60.34393363
120PAK30.33094407
121BCKDK0.32429970
122NTRK20.32216141
123MARK20.30064207
124GSK3B0.29956039
125PDK10.29839726
126CDK10.28951844
127AKT20.28891183
128MAPK30.27901150
129DDR20.27134208
130GSK3A0.27044080
131PRKDC0.27030993
132CDK20.26670795
133JAK10.26098875
134CSNK1G20.25811915
135SMG10.25611214
136CSNK2A10.25294750
137CSNK2A20.24995079
138PRKD20.24763723
139CSNK1G30.24192717
140MAP2K30.24021519
141MAP3K20.23802815
142CHUK0.22466781
143PAK10.21670503
144KSR20.21504897
145FGFR40.21149953
146CSK0.21064306
147ROCK10.20527811
148MAPK140.20330180
149CSNK1G10.20205807
150PLK10.19397595
151MAPK80.18936764
152STK40.18263938
153ERBB20.17697560
154MINK10.17595025
155DAPK30.17146153
156RPS6KA30.16584461

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.09194404
2Fatty acid biosynthesis_Homo sapiens_hsa000614.08076542
3Dorso-ventral axis formation_Homo sapiens_hsa043203.13223458
4Fatty acid metabolism_Homo sapiens_hsa012123.07263053
5Vitamin digestion and absorption_Homo sapiens_hsa049772.89673282
6Pyruvate metabolism_Homo sapiens_hsa006202.80120010
7Ovarian steroidogenesis_Homo sapiens_hsa049132.73085158
8Arginine biosynthesis_Homo sapiens_hsa002202.50973500
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40222735
10Phenylalanine metabolism_Homo sapiens_hsa003602.26119292
11Fatty acid degradation_Homo sapiens_hsa000712.22337820
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.19083183
13PPAR signaling pathway_Homo sapiens_hsa033202.14426692
14Histidine metabolism_Homo sapiens_hsa003402.12291971
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.11288585
16Lysine degradation_Homo sapiens_hsa003102.10135739
17ECM-receptor interaction_Homo sapiens_hsa045122.06884047
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04307880
19Caffeine metabolism_Homo sapiens_hsa002322.03195396
20Propanoate metabolism_Homo sapiens_hsa006402.02625543
21Tyrosine metabolism_Homo sapiens_hsa003501.95098339
22Protein digestion and absorption_Homo sapiens_hsa049741.89896036
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.79958868
24mRNA surveillance pathway_Homo sapiens_hsa030151.79220296
25Butanoate metabolism_Homo sapiens_hsa006501.73283031
26Steroid biosynthesis_Homo sapiens_hsa001001.70197833
27Amoebiasis_Homo sapiens_hsa051461.69250659
28Hedgehog signaling pathway_Homo sapiens_hsa043401.68947921
29TGF-beta signaling pathway_Homo sapiens_hsa043501.66297759
30Starch and sucrose metabolism_Homo sapiens_hsa005001.65654782
31Small cell lung cancer_Homo sapiens_hsa052221.65391359
32Fatty acid elongation_Homo sapiens_hsa000621.61623979
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54138324
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52768954
35Selenocompound metabolism_Homo sapiens_hsa004501.51070059
36Glycerolipid metabolism_Homo sapiens_hsa005611.50855202
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49103606
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.47278460
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45625066
40Staphylococcus aureus infection_Homo sapiens_hsa051501.45364243
41Renin secretion_Homo sapiens_hsa049241.42364779
42Fat digestion and absorption_Homo sapiens_hsa049751.39579490
43Arginine and proline metabolism_Homo sapiens_hsa003301.37457624
44Mineral absorption_Homo sapiens_hsa049781.36983108
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32137333
46Peroxisome_Homo sapiens_hsa041461.29686522
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29464671
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.29061953
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19459633
50Focal adhesion_Homo sapiens_hsa045101.12236392
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.11949023
52Glucagon signaling pathway_Homo sapiens_hsa049221.10873916
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.10560361
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10317381
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09807332
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09510532
57Antigen processing and presentation_Homo sapiens_hsa046121.07968274
58Toxoplasmosis_Homo sapiens_hsa051451.06312174
59ABC transporters_Homo sapiens_hsa020101.05914301
60Prion diseases_Homo sapiens_hsa050201.05721824
61Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05442933
62Oocyte meiosis_Homo sapiens_hsa041141.05207393
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04658336
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.03787040
65beta-Alanine metabolism_Homo sapiens_hsa004101.01392452
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00490988
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00122577
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99924373
69Bile secretion_Homo sapiens_hsa049760.99365007
70Other glycan degradation_Homo sapiens_hsa005110.99173502
71Axon guidance_Homo sapiens_hsa043600.97771674
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97547253
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93731183
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.91195495
75RNA transport_Homo sapiens_hsa030130.90510469
76cAMP signaling pathway_Homo sapiens_hsa040240.89879669
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89856602
78Estrogen signaling pathway_Homo sapiens_hsa049150.88294761
79Retinol metabolism_Homo sapiens_hsa008300.88269057
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87221146
81Chemical carcinogenesis_Homo sapiens_hsa052040.86000031
82Insulin resistance_Homo sapiens_hsa049310.85146396
83Notch signaling pathway_Homo sapiens_hsa043300.84728150
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82695668
85Basal transcription factors_Homo sapiens_hsa030220.79554996
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76556969
87Basal cell carcinoma_Homo sapiens_hsa052170.76321347
88Tight junction_Homo sapiens_hsa045300.76070735
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75151708
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73835737
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72317897
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.68689486
93* Complement and coagulation cascades_Homo sapiens_hsa046100.67921511
94Fructose and mannose metabolism_Homo sapiens_hsa000510.65891308
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65786455
96One carbon pool by folate_Homo sapiens_hsa006700.64078970
97Viral myocarditis_Homo sapiens_hsa054160.62235526
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62013092
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61948268
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59682952
101Linoleic acid metabolism_Homo sapiens_hsa005910.59265348
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.58496700
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58352317
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58043943
105Hippo signaling pathway_Homo sapiens_hsa043900.56813000
106Pancreatic secretion_Homo sapiens_hsa049720.56671561
107Galactose metabolism_Homo sapiens_hsa000520.56612310
108Carbon metabolism_Homo sapiens_hsa012000.56035330
109Sulfur metabolism_Homo sapiens_hsa009200.55650449
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55116586
111Influenza A_Homo sapiens_hsa051640.50635363
112VEGF signaling pathway_Homo sapiens_hsa043700.50467033
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50229576
114N-Glycan biosynthesis_Homo sapiens_hsa005100.49347524
115Nitrogen metabolism_Homo sapiens_hsa009100.48746273
116Biosynthesis of amino acids_Homo sapiens_hsa012300.48521075
117AMPK signaling pathway_Homo sapiens_hsa041520.48276713
118Thyroid hormone synthesis_Homo sapiens_hsa049180.47598862
119Gastric acid secretion_Homo sapiens_hsa049710.47371356
120Vitamin B6 metabolism_Homo sapiens_hsa007500.46210295
121Renin-angiotensin system_Homo sapiens_hsa046140.46030700
122Inositol phosphate metabolism_Homo sapiens_hsa005620.45005346
123Tryptophan metabolism_Homo sapiens_hsa003800.44609142
124Adherens junction_Homo sapiens_hsa045200.44281223
125Metabolic pathways_Homo sapiens_hsa011000.44225216
126Arachidonic acid metabolism_Homo sapiens_hsa005900.43249381
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.43043203
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41968905
129Pertussis_Homo sapiens_hsa051330.41330069
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.40423686
131Herpes simplex infection_Homo sapiens_hsa051680.39844246
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36748784
133Sulfur relay system_Homo sapiens_hsa041220.35916707
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34297924
135Glutathione metabolism_Homo sapiens_hsa004800.33061349
136Wnt signaling pathway_Homo sapiens_hsa043100.32016520
137mTOR signaling pathway_Homo sapiens_hsa041500.31777198
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28859997
139Pathways in cancer_Homo sapiens_hsa052000.28807169
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28712067
141Pentose phosphate pathway_Homo sapiens_hsa000300.27639551
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25930633
143Sphingolipid metabolism_Homo sapiens_hsa006000.23520932
144Insulin signaling pathway_Homo sapiens_hsa049100.08697166
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.04308381
146Circadian rhythm_Homo sapiens_hsa047100.00053590
147Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0350356

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