SERPINA9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1snRNA transcription (GO:0009301)7.83329557
2positive regulation of B cell differentiation (GO:0045579)7.35242070
3B cell proliferation (GO:0042100)7.19858032
4regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.74291579
5negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 6.73844432
6positive regulation of gamma-delta T cell activation (GO:0046645)6.39837840
7daunorubicin metabolic process (GO:0044597)6.12228090
8polyketide metabolic process (GO:0030638)6.12228090
9doxorubicin metabolic process (GO:0044598)6.12228090
10regulation of B cell differentiation (GO:0045577)6.00052381
11positive thymic T cell selection (GO:0045059)5.87139370
12somatic hypermutation of immunoglobulin genes (GO:0016446)5.77117773
13somatic diversification of immune receptors via somatic mutation (GO:0002566)5.77117773
14negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)5.69054766
15regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 5.64574149
16regulation of gamma-delta T cell differentiation (GO:0045586)5.07685338
17regulation of germinal center formation (GO:0002634)4.71442595
18negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.65083257
19negative regulation of T-helper cell differentiation (GO:0045623)4.65083257
20regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)4.57956100
21synaptic transmission, dopaminergic (GO:0001963)4.47694231
22positive regulation of B cell proliferation (GO:0030890)4.41666567
23positive T cell selection (GO:0043368)4.39390744
24regulation of gamma-delta T cell activation (GO:0046643)4.38823004
25auditory behavior (GO:0031223)4.38212260
26production of molecular mediator involved in inflammatory response (GO:0002532)4.32787071
27regulation of T-helper 2 cell differentiation (GO:0045628)4.31974577
28immunoglobulin mediated immune response (GO:0016064)4.31574114
29B cell homeostasis (GO:0001782)4.23331344
30regulation of B cell receptor signaling pathway (GO:0050855)4.22172246
31regulation of interferon-beta biosynthetic process (GO:0045357)4.18017195
32positive regulation of B cell activation (GO:0050871)4.11195111
33prepulse inhibition (GO:0060134)4.10335519
34positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.10276345
35striatum development (GO:0021756)4.08653752
36antigen receptor-mediated signaling pathway (GO:0050851)4.06980874
37neurotransmitter-gated ion channel clustering (GO:0072578)4.04184597
38positive regulation of DNA-templated transcription, elongation (GO:0032786)4.02542772
39regulation of glucocorticoid metabolic process (GO:0031943)4.00446288
40negative regulation of bone resorption (GO:0045779)3.97501269
41ionotropic glutamate receptor signaling pathway (GO:0035235)3.95867577
42response to auditory stimulus (GO:0010996)3.95540791
43vocalization behavior (GO:0071625)3.92892858
44startle response (GO:0001964)3.92874456
45regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90892526
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.89566885
47negative regulation of histone methylation (GO:0031061)3.88909058
48presynaptic membrane assembly (GO:0097105)3.81119285
49regulation of B cell proliferation (GO:0030888)3.76568090
50defense response to protozoan (GO:0042832)3.76048227
51vesicle targeting (GO:0006903)3.75984198
52behavioral response to cocaine (GO:0048148)3.75769711
53regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.73650574
54response to amphetamine (GO:0001975)3.72629988
55neuron-neuron synaptic transmission (GO:0007270)3.72575025
56neuron cell-cell adhesion (GO:0007158)3.71675796
57cAMP catabolic process (GO:0006198)3.69686524
58lymphocyte proliferation (GO:0046651)3.68888108
59aminoglycoside antibiotic metabolic process (GO:0030647)3.68297827
60mast cell degranulation (GO:0043303)3.64404792
61mast cell activation involved in immune response (GO:0002279)3.64404792
62regulation of fibroblast apoptotic process (GO:2000269)3.62649209
63mononuclear cell proliferation (GO:0032943)3.61411012
64negative regulation of T cell differentiation (GO:0045581)3.61225599
65synaptic transmission, glutamatergic (GO:0035249)3.59879182
66presynaptic membrane organization (GO:0097090)3.58978376
67regulation of histone H3-K9 methylation (GO:0051570)3.57552303
68T cell selection (GO:0045058)3.56798116
69cellular extravasation (GO:0045123)3.55434212
70negative regulation of signal transduction by p53 class mediator (GO:1901797)3.54178737
71cyclic nucleotide catabolic process (GO:0009214)3.53376080
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.52802485
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.52671334
74G-protein coupled receptor internalization (GO:0002031)3.52408991
75mechanosensory behavior (GO:0007638)3.51719308
76glutamate receptor signaling pathway (GO:0007215)3.49723300
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47625492
78activation of MAPKKK activity (GO:0000185)3.47363569
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.44956537
80thymic T cell selection (GO:0045061)3.43747821
81negative regulation of hormone biosynthetic process (GO:0032353)3.43376779
82adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.42892800
83somatic diversification of immunoglobulins (GO:0016445)3.41593460
84B cell activation (GO:0042113)3.41347797
85drinking behavior (GO:0042756)3.40346635
86regulation of antigen processing and presentation (GO:0002577)3.38819245
87B cell mediated immunity (GO:0019724)3.38490036
88regulation of glutamate receptor signaling pathway (GO:1900449)3.37926260
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.37552672
90cellular response to type I interferon (GO:0071357)3.28482468
91type I interferon signaling pathway (GO:0060337)3.28482468
92leukocyte proliferation (GO:0070661)3.26412458
93CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.25657602
94Arp2/3 complex-mediated actin nucleation (GO:0034314)3.25589170
95postsynaptic membrane organization (GO:0001941)3.25583936
96regulation of glutamate secretion (GO:0014048)3.24706979
97response to type I interferon (GO:0034340)3.24476594
98positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.23328717
99phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.22775738
100immune response-activating cell surface receptor signaling pathway (GO:0002429)3.22568525
101transmission of nerve impulse (GO:0019226)3.20404051
102antigen processing and presentation of endogenous antigen (GO:0019883)3.19653348
103negative regulation of bone remodeling (GO:0046851)3.18198381
104mucosal-associated lymphoid tissue development (GO:0048537)3.18000664
105Peyers patch development (GO:0048541)3.18000664
106regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.17746022
107regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.17746022
108negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)3.15321561
109negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13115156
110sodium ion export (GO:0071436)3.12192140
111G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11842336
112response to histamine (GO:0034776)3.11833437
113membrane raft organization (GO:0031579)3.11350205
114membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.11347334
115negative regulation of B cell apoptotic process (GO:0002903)3.09973056
116positive regulation of toll-like receptor signaling pathway (GO:0034123)3.09531377
117negative regulation of alpha-beta T cell differentiation (GO:0046639)3.09071746
118female mating behavior (GO:0060180)3.08364365
119positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.08350333
120regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08130429
121regulation of neurotransmitter uptake (GO:0051580)3.06564120
122negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04004023
123negative regulation of fibroblast apoptotic process (GO:2000270)3.03297189
124regulation of B cell apoptotic process (GO:0002902)3.00819125
125mast cell activation (GO:0045576)3.00693117
126response to protozoan (GO:0001562)3.00043929
127regulation of B cell activation (GO:0050864)2.99381053
128mitochondrion distribution (GO:0048311)2.96148912
129protein localization to synapse (GO:0035418)2.94380432
130substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.93477402
131substrate-independent telencephalic tangential migration (GO:0021826)2.93477402
132negative regulation of hormone metabolic process (GO:0032351)2.93019994
133regulation of female receptivity (GO:0045924)2.91864203
134natural killer cell differentiation (GO:0001779)2.88742521
135mature B cell differentiation (GO:0002335)2.88483373
136behavioral defense response (GO:0002209)2.88125214
137behavioral fear response (GO:0001662)2.88125214
138long-term synaptic potentiation (GO:0060291)2.87849721
139regulation of excitatory postsynaptic membrane potential (GO:0060079)2.87084442
140regulation of superoxide anion generation (GO:0032928)2.86629943
141visual learning (GO:0008542)2.86556587
142positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.85627367
143positive regulation of type 2 immune response (GO:0002830)2.84475302
144hepatocyte apoptotic process (GO:0097284)2.84463084
145adaptive immune response (GO:0002250)2.83985982
146lymphocyte homeostasis (GO:0002260)2.83805542
147macrophage activation involved in immune response (GO:0002281)2.83166607
148adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.83020932
149regulation of synapse structural plasticity (GO:0051823)2.80158116
150L-amino acid import (GO:0043092)2.80023889
151T cell homeostasis (GO:0043029)2.80011514
152regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78788668
153gamma-aminobutyric acid transport (GO:0015812)2.78602033
154regulation of long-term neuronal synaptic plasticity (GO:0048169)2.78520381
155B cell activation involved in immune response (GO:0002312)2.78134087
156positive regulation of DNA-templated transcription, initiation (GO:2000144)2.77887011
157positive regulation of action potential (GO:0045760)2.76634479
158phosphorelay signal transduction system (GO:0000160)2.76533340
159negative regulation of cell killing (GO:0031342)2.76166035
160negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.76166035
161long-term memory (GO:0007616)2.73639253
162regulation of synaptic transmission, GABAergic (GO:0032228)2.73501373
163neuronal ion channel clustering (GO:0045161)2.73424484
164cerebral cortex radially oriented cell migration (GO:0021799)2.72698409
165learning (GO:0007612)2.72684393
166associative learning (GO:0008306)2.69132830
167regulation of synapse maturation (GO:0090128)2.68627833
168glycine transport (GO:0015816)2.67620763
169serotonin receptor signaling pathway (GO:0007210)2.67562367
170regulation of dendritic spine morphogenesis (GO:0061001)2.67431747
171long-chain fatty acid biosynthetic process (GO:0042759)2.67235987
172cellular response to interferon-beta (GO:0035458)2.66457633
173activation of JUN kinase activity (GO:0007257)2.65380185
174positive regulation of Rap GTPase activity (GO:0032854)2.65032847
175neuronal action potential (GO:0019228)2.62503175
176visual behavior (GO:0007632)2.62457549
177regulation of postsynaptic membrane potential (GO:0060078)2.62052959
178positive regulation of amino acid transport (GO:0051957)2.61651297
179negative regulation of dendrite development (GO:2000171)2.61316614
180cAMP metabolic process (GO:0046058)2.60366701
181gamma-aminobutyric acid signaling pathway (GO:0007214)2.59890163
182opioid receptor signaling pathway (GO:0038003)2.59700244
183synaptic vesicle maturation (GO:0016188)2.59488262
184multicellular organismal reproductive behavior (GO:0033057)2.59073083
185locomotory exploration behavior (GO:0035641)2.58208840
186regulation of voltage-gated calcium channel activity (GO:1901385)2.57740003
187regulation of amino acid transport (GO:0051955)2.56480999
188fear response (GO:0042596)2.55974168
189tachykinin receptor signaling pathway (GO:0007217)2.55766551
190membrane hyperpolarization (GO:0060081)2.54322695
191synapse assembly (GO:0007416)2.54110220
192reflex (GO:0060004)2.53605095
193negative regulation of amino acid transport (GO:0051956)2.53237968
194dendritic spine morphogenesis (GO:0060997)2.50995744
195regulation of neuronal synaptic plasticity (GO:0048168)2.50994697
196neuronal action potential propagation (GO:0019227)2.50703667
197negative regulation of neurotransmitter transport (GO:0051589)2.50565250
198dopamine receptor signaling pathway (GO:0007212)2.50540138
199B cell receptor signaling pathway (GO:0050853)10.8495755
200germinal center formation (GO:0002467)10.1207653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human7.19200409
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.76776375
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.10512776
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.85225062
5E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human4.69112284
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.97077697
7EZH2_22144423_ChIP-Seq_EOC_Human3.66376355
8GBX2_23144817_ChIP-Seq_PC3_Human3.55558197
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.48995700
10E2F7_22180533_ChIP-Seq_HELA_Human3.33161707
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.31388995
12* IRF8_21731497_ChIP-ChIP_J774_Mouse3.18150419
13CIITA_25753668_ChIP-Seq_RAJI_Human3.15362872
14BP1_19119308_ChIP-ChIP_Hs578T_Human3.05718305
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88053800
16RUNX_20019798_ChIP-Seq_JUKART_Human2.77866948
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77216933
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76508736
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.62031813
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50860177
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46169182
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45400312
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42958412
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42958412
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.42827117
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40907315
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40736355
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33417574
29MYB_26560356_Chip-Seq_TH2_Human2.32902622
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31497856
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.30066342
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25899293
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24033212
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22554987
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17918262
36BMI1_23680149_ChIP-Seq_NPCS_Mouse2.16883926
37EZH2_27294783_Chip-Seq_ESCs_Mouse2.14817757
38ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13311375
39RNF2_27304074_Chip-Seq_ESCs_Mouse2.08834598
40MYB_26560356_Chip-Seq_TH1_Human2.07225514
41SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05089736
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02608435
43SPI1_23547873_ChIP-Seq_NB4_Human2.02486801
44ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02035015
45CBX2_27304074_Chip-Seq_ESCs_Mouse2.01848698
46MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01300068
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00833613
48NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.00051935
49VDR_21846776_ChIP-Seq_THP-1_Human1.99016695
50REST_21632747_ChIP-Seq_MESCs_Mouse1.93663297
51RNF2_27304074_Chip-Seq_NSC_Mouse1.87551450
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.87499299
53UTX_26944678_Chip-Seq_JUKART_Human1.87119077
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86417792
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84623507
56MAF_26560356_Chip-Seq_TH1_Human1.83415674
57VDR_22108803_ChIP-Seq_LS180_Human1.81299651
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.80345056
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76871304
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75070862
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74656185
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67892150
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66724312
64IGF1R_20145208_ChIP-Seq_DFB_Human1.64897031
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.62900893
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61579475
67TAF15_26573619_Chip-Seq_HEK293_Human1.60443100
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59779886
69SPI1_23127762_ChIP-Seq_K562_Human1.58547778
70DROSHA_22980978_ChIP-Seq_HELA_Human1.57448755
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56243162
72VDR_24763502_ChIP-Seq_THP-1_Human1.55611972
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55600533
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53414990
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51737769
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.51641351
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51188743
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.50164410
79P300_19829295_ChIP-Seq_ESCs_Human1.48052787
80SMAD4_21799915_ChIP-Seq_A2780_Human1.47919063
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47585565
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46313143
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43259709
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.42898539
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.41878724
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40791141
87MAF_26560356_Chip-Seq_TH2_Human1.39255387
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38859225
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.37788195
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36993524
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36450435
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35721968
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.33080530
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31648716
95AR_21572438_ChIP-Seq_LNCaP_Human1.31336285
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31199922
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29797372
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.28830732
99SMAD_19615063_ChIP-ChIP_OVARY_Human1.27769463
100TCF7_22412390_ChIP-Seq_EML_Mouse1.26651469
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.26539816
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25747398
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23932242
104CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23929679
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22710044
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.22413998
107KDM2B_26808549_Chip-Seq_DND41_Human1.22105192
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21058434
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20674672
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20665284
111GATA3_27048872_Chip-Seq_THYMUS_Human1.20496691
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20000226
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19398529
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19186229
115BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16864912
116CMYC_18555785_Chip-Seq_ESCs_Mouse1.16712541
117IRF1_19129219_ChIP-ChIP_H3396_Human1.16245562
118STAT3_23295773_ChIP-Seq_U87_Human1.16051339
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15441606
120FOXP3_21729870_ChIP-Seq_TREG_Human1.14779758
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14754838
122PU_27001747_Chip-Seq_BMDM_Mouse1.14520152
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.14282519
124SMRT_27268052_Chip-Seq_Bcells_Human1.13670562
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13424054
126RING1B_27294783_Chip-Seq_NPCs_Mouse1.13388410
127AR_25329375_ChIP-Seq_VCAP_Human1.12524339
128NOTCH1_21737748_ChIP-Seq_TLL_Human1.12524092
129SMAD3_21741376_ChIP-Seq_HESCs_Human1.12405012
130P53_22387025_ChIP-Seq_ESCs_Mouse1.12140296
131MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12098375
132RUNX2_22187159_ChIP-Seq_PCA_Human1.11651619
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11153632
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.10695403
135RING1B_27294783_Chip-Seq_ESCs_Mouse1.10636087
136NMYC_18555785_Chip-Seq_ESCs_Mouse1.10299554
137MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10076551
138NFE2_27457419_Chip-Seq_LIVER_Mouse1.09731845
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09644136
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09644136
141TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09236212
142POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09203473
143EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08844152
144P300_18555785_Chip-Seq_ESCs_Mouse1.07398394
145RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06950776
146AHR_22903824_ChIP-Seq_MCF-7_Human1.06642264
147RUNX1_27457419_Chip-Seq_LIVER_Mouse1.05621943
148RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05173239
149ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04108998
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03703414
151SOX2_18555785_Chip-Seq_ESCs_Mouse1.03607013
152FUS_26573619_Chip-Seq_HEK293_Human1.02988660
153ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02248555
154FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01770906
155OCT4_18555785_Chip-Seq_ESCs_Mouse1.01597929
156ARNT_22903824_ChIP-Seq_MCF-7_Human1.01438288
157TAL1_26923725_Chip-Seq_HPCs_Mouse1.00589451
158ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00539155
159* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00432820
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00257282
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.99394728
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98867832
163TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98801591
164OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98385068
165SOX2_21211035_ChIP-Seq_LN229_Gbm0.97735508
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97427579
167KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96924135
168TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95688568
169CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92914025
170RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92880038
171GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88042833
172STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87196075
173ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85856046
174TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84696681
175VDR_23849224_ChIP-Seq_CD4+_Human0.83197059
176BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81712144
177HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.81635481
178FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81111471
179ELK3_25401928_ChIP-Seq_HUVEC_Human0.78923858
180SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78843773
181GATA3_26560356_Chip-Seq_TH2_Human0.78283933
182P300_27268052_Chip-Seq_Bcells_Human0.78265464
183SPI1_26923725_Chip-Seq_HPCs_Mouse0.77871504
184KDM5A_27292631_Chip-Seq_BREAST_Human0.75200228
185CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73872214
186SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72869491
187KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.70428472
188GATA3_26560356_Chip-Seq_TH1_Human0.69147584
189GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69049036
190PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68988585
191BCL6_27268052_Chip-Seq_Bcells_Human0.67267082
192TP63_19390658_ChIP-ChIP_HaCaT_Human0.66908299
193BCOR_27268052_Chip-Seq_Bcells_Human0.66336908
194PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66238538
195CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65961627
196NANOG_18555785_ChIP-Seq_MESCs_Mouse0.65771531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.38089332
2MP0001800_abnormal_humoral_immune4.60921025
3MP0005387_immune_system_phenotype4.39183959
4MP0001790_abnormal_immune_system4.39183959
5MP0001835_abnormal_antigen_presentation4.23410466
6MP0000685_abnormal_immune_system3.97113446
7MP0003880_abnormal_central_pattern3.96930200
8MP0005000_abnormal_immune_tolerance3.85826184
9MP0003763_abnormal_thymus_physiology3.82498595
10MP0006292_abnormal_olfactory_placode3.65688829
11MP0004859_abnormal_synaptic_plasticity3.36860022
12MP0002452_abnormal_antigen_presenting3.33818614
13MP0001486_abnormal_startle_reflex3.15095143
14MP0008057_abnormal_DNA_replication3.07882950
15MP0001188_hyperpigmentation3.06201194
16MP0009745_abnormal_behavioral_response3.02367797
17MP0002723_abnormal_immune_serum2.79082902
18MP0002420_abnormal_adaptive_immunity2.75598445
19MP0005646_abnormal_pituitary_gland2.74058210
20MP0003635_abnormal_synaptic_transmissio2.72401901
21MP0002398_abnormal_bone_marrow2.68929644
22MP0000013_abnormal_adipose_tissue2.68692570
23MP0003303_peritoneal_inflammation2.66077057
24MP0000537_abnormal_urethra_morphology2.65026165
25MP0002063_abnormal_learning/memory/cond2.55569889
26MP0003436_decreased_susceptibility_to2.54372600
27MP0001819_abnormal_immune_cell2.50938444
28MP0000689_abnormal_spleen_morphology2.44923657
29MP0002572_abnormal_emotion/affect_behav2.43547201
30MP0002254_reproductive_system_inflammat2.40462468
31MP0009046_muscle_twitch2.38168311
32MP0000716_abnormal_immune_system2.32913110
33MP0001984_abnormal_olfaction2.28975405
34MP0002064_seizures2.26673376
35MP0005499_abnormal_olfactory_system2.24226201
36MP0005394_taste/olfaction_phenotype2.24226201
37MP0001529_abnormal_vocalization2.16937874
38MP0002277_abnormal_respiratory_mucosa2.13625455
39MP0001501_abnormal_sleep_pattern2.10254752
40MP0005423_abnormal_somatic_nervous2.07121336
41MP0002272_abnormal_nervous_system2.03487526
42MP0002722_abnormal_immune_system1.99277625
43MP0000465_gastrointestinal_hemorrhage1.95923801
44MP0010094_abnormal_chromosome_stability1.93521234
45MP0001968_abnormal_touch/_nociception1.85731301
46MP0002429_abnormal_blood_cell1.82731302
47MP0004381_abnormal_hair_follicle1.80438527
48MP0005025_abnormal_response_to1.77231040
49MP0008004_abnormal_stomach_pH1.74166380
50MP0003136_yellow_coat_color1.72840915
51MP0009785_altered_susceptibility_to1.70408537
52MP0005645_abnormal_hypothalamus_physiol1.68034903
53MP0002405_respiratory_system_inflammati1.67627293
54MP0001853_heart_inflammation1.65760457
55MP0005671_abnormal_response_to1.64736026
56MP0002736_abnormal_nociception_after1.62127421
57MP0002396_abnormal_hematopoietic_system1.61931288
58MP0002148_abnormal_hypersensitivity_rea1.58751292
59MP0003111_abnormal_nucleus_morphology1.57715517
60MP0002557_abnormal_social/conspecific_i1.57052980
61MP0003787_abnormal_imprinting1.55582353
62MP0002735_abnormal_chemical_nociception1.52536755
63MP0001845_abnormal_inflammatory_respons1.49661660
64MP0003693_abnormal_embryo_hatching1.49342180
65MP0002067_abnormal_sensory_capabilities1.48603731
66MP0002876_abnormal_thyroid_physiology1.48456925
67MP0003077_abnormal_cell_cycle1.46851766
68MP0000703_abnormal_thymus_morphology1.46798441
69MP0004270_analgesia1.46004542
70MP0002734_abnormal_mechanical_nocicepti1.44514199
71MP0005409_darkened_coat_color1.44395680
72MP0005451_abnormal_body_composition1.44208621
73MP0001905_abnormal_dopamine_level1.44155727
74MP0005248_abnormal_Harderian_gland1.43479617
75MP0001440_abnormal_grooming_behavior1.40437092
76MP0006276_abnormal_autonomic_nervous1.40154185
77MP0002638_abnormal_pupillary_reflex1.39459162
78MP0001502_abnormal_circadian_rhythm1.38085142
79MP0004142_abnormal_muscle_tone1.34318586
80MP0005171_absent_coat_pigmentation1.34104777
81MP0001970_abnormal_pain_threshold1.33976290
82MP0002184_abnormal_innervation1.32979058
83MP0002009_preneoplasia1.30965572
84MP0003300_gastrointestinal_ulcer1.28959243
85MP0005075_abnormal_melanosome_morpholog1.28797733
86MP0004858_abnormal_nervous_system1.28410707
87MP0002419_abnormal_innate_immunity1.28155031
88MP0002166_altered_tumor_susceptibility1.26297059
89MP0005551_abnormal_eye_electrophysiolog1.25274090
90MP0003122_maternal_imprinting1.24631002
91MP0001346_abnormal_lacrimal_gland1.24203610
92MP0010234_abnormal_vibrissa_follicle1.23423184
93MP0000778_abnormal_nervous_system1.23316663
94MP0000003_abnormal_adipose_tissue1.22790062
95MP0008995_early_reproductive_senescence1.19525136
96MP0005464_abnormal_platelet_physiology1.19497274
97MP0000566_synostosis1.19231177
98MP0003011_delayed_dark_adaptation1.17443091
99MP0002019_abnormal_tumor_incidence1.17064784
100MP0004947_skin_inflammation1.17043928
101MP0002733_abnormal_thermal_nociception1.14113753
102MP0000631_abnormal_neuroendocrine_gland1.11568854
103MP0004742_abnormal_vestibular_system1.10129258
104MP0002136_abnormal_kidney_physiology1.07785762
105MP0008872_abnormal_physiological_respon1.07662485
106MP0001873_stomach_inflammation1.07420997
107MP0003938_abnormal_ear_development1.07152881
108MP0010386_abnormal_urinary_bladder1.06248837
109MP0010155_abnormal_intestine_physiology1.05201626
110MP0005257_abnormal_intraocular_pressure1.05070049
111MP0000026_abnormal_inner_ear1.04657382
112MP0001986_abnormal_taste_sensitivity1.04408711
113MP0004808_abnormal_hematopoietic_stem1.04247944
114MP0003091_abnormal_cell_migration1.03891469
115MP0003890_abnormal_embryonic-extraembry1.02737455
116MP0000762_abnormal_tongue_morphology1.02488256
117MP0008789_abnormal_olfactory_epithelium1.02182880
118MP0002006_tumorigenesis0.99027340
119MP0001963_abnormal_hearing_physiology0.98371865
120MP0002752_abnormal_somatic_nervous0.97975776
121MP0002249_abnormal_larynx_morphology0.97946262
122MP0005386_behavior/neurological_phenoty0.97873458
123MP0004924_abnormal_behavior0.97873458
124MP0004036_abnormal_muscle_relaxation0.97597858
125MP0002102_abnormal_ear_morphology0.96807833
126MP0000350_abnormal_cell_proliferation0.95871620
127MP0000955_abnormal_spinal_cord0.94416360
128MP0002882_abnormal_neuron_morphology0.93444908
129MP0000538_abnormal_urinary_bladder0.93175792
130MP0003137_abnormal_impulse_conducting0.92386306
131MP0002909_abnormal_adrenal_gland0.90959679
132MP0003879_abnormal_hair_cell0.90905972
133MP0004085_abnormal_heartbeat0.89649246
134MP0000313_abnormal_cell_death0.89463592
135MP0000015_abnormal_ear_pigmentation0.89231967
136MP0004782_abnormal_surfactant_physiolog0.87361667
137MP0002066_abnormal_motor_capabilities/c0.86848027
138MP0005166_decreased_susceptibility_to0.86748379
139MP0000249_abnormal_blood_vessel0.86580332
140MP0005167_abnormal_blood-brain_barrier0.86326215
141MP0000678_abnormal_parathyroid_gland0.85741759
142MP0005310_abnormal_salivary_gland0.83855454
143MP0009697_abnormal_copulation0.83816422
144MP0004885_abnormal_endolymph0.83709041
145MP0010307_abnormal_tumor_latency0.81055541
146MP0003690_abnormal_glial_cell0.79420797
147MP0008569_lethality_at_weaning0.79152130
148MP0002127_abnormal_cardiovascular_syste0.78977964
149MP0010678_abnormal_skin_adnexa0.78954365
150MP0004957_abnormal_blastocyst_morpholog0.78165137
151MP0000049_abnormal_middle_ear0.77903360
152MP0003866_abnormal_defecation0.76925120
153MP0005253_abnormal_eye_physiology0.76298070
154MP0003183_abnormal_peptide_metabolism0.76192550
155MP0002069_abnormal_eating/drinking_beha0.75909416
156MP0002877_abnormal_melanocyte_morpholog0.75225529
157MP0001177_atelectasis0.75137720
158MP0008469_abnormal_protein_level0.73964427
159MP0000920_abnormal_myelination0.73675909
160MP0002933_joint_inflammation0.73050406
161MP0002090_abnormal_vision0.72372474
162MP0003941_abnormal_skin_development0.71953074
163MP0000383_abnormal_hair_follicle0.69543968
164MP0002332_abnormal_exercise_endurance0.68609940
165MP0005621_abnormal_cell_physiology0.68127479
166MP0008058_abnormal_DNA_repair0.67554201
167MP0002132_abnormal_respiratory_system0.64654553
168MP0002796_impaired_skin_barrier0.64365259
169MP0008874_decreased_physiological_sensi0.64262670
170MP0005275_abnormal_skin_tensile0.64001343
171MP0003786_premature_aging0.62568334
172MP0003566_abnormal_cell_adhesion0.62080677
173MP0010352_gastrointestinal_tract_polyps0.61884199
174MP0002138_abnormal_hepatobiliary_system0.61412896
175MP0001661_extended_life_span0.60235028
176MP0005375_adipose_tissue_phenotype0.59559682
177MP0002083_premature_death0.58599150
178MP0009763_increased_sensitivity_to0.57405495
179MP0002095_abnormal_skin_pigmentation0.55242319
180MP0003191_abnormal_cellular_cholesterol0.54787774
181MP0009764_decreased_sensitivity_to0.54787212
182MP0003868_abnormal_feces_composition0.54272318
183MP0000490_abnormal_crypts_of0.54256479
184MP0001730_embryonic_growth_arrest0.52776848
185MP0005501_abnormal_skin_physiology0.51528679
186MP0000609_abnormal_liver_physiology0.51297733
187MP0000767_abnormal_smooth_muscle0.50239955
188MP0000613_abnormal_salivary_gland0.49243431
189MP0004084_abnormal_cardiac_muscle0.49199275
190MP0004043_abnormal_pH_regulation0.47459818
191MP0008007_abnormal_cellular_replicative0.46808327

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)9.17283938
2Lymphopenia (HP:0001888)6.36902102
3Emphysema (HP:0002097)6.24373701
4Focal motor seizures (HP:0011153)5.93370746
5Recurrent bronchitis (HP:0002837)5.82941351
6Abnormality of cells of the lymphoid lineage (HP:0012140)5.58802714
7Panhypogammaglobulinemia (HP:0003139)5.34586474
8Recurrent sinusitis (HP:0011108)5.17539353
9Cellulitis (HP:0100658)5.07643361
10IgA deficiency (HP:0002720)5.07349633
11Febrile seizures (HP:0002373)5.04967639
12Meningitis (HP:0001287)4.79531162
13Colitis (HP:0002583)4.78565626
14Papilloma (HP:0012740)4.72575164
15Verrucae (HP:0200043)4.72575164
16Vasculitis (HP:0002633)4.60235193
17Hyperventilation (HP:0002883)4.56107333
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.52844236
19Viral hepatitis (HP:0006562)4.35541804
20Mediastinal lymphadenopathy (HP:0100721)4.35248011
21Restrictive lung disease (HP:0002091)4.23707219
22Recurrent viral infections (HP:0004429)4.14045185
23Epileptic encephalopathy (HP:0200134)4.10810468
24Gastrointestinal inflammation (HP:0004386)3.95618394
25Hypoplasia of the thymus (HP:0000778)3.95602876
26Lymphoma (HP:0002665)3.90836935
27Inflammation of the large intestine (HP:0002037)3.89136287
28Myokymia (HP:0002411)3.88236013
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.81970255
30Bilateral microphthalmos (HP:0007633)3.72389806
31Recurrent cutaneous fungal infections (HP:0011370)3.71248388
32Chronic mucocutaneous candidiasis (HP:0002728)3.71248388
33Chronic sinusitis (HP:0011109)3.69769211
34Chronic diarrhea (HP:0002028)3.67953031
35Osteomyelitis (HP:0002754)3.58663309
36Focal seizures (HP:0007359)3.55359916
37Recurrent lower respiratory tract infections (HP:0002783)3.47418826
38Aplasia/Hypoplasia of the fovea (HP:0008060)3.42812995
39Hypoplasia of the fovea (HP:0007750)3.42812995
40Leukopenia (HP:0001882)3.42001453
41Encephalitis (HP:0002383)3.34150786
42Anomalous pulmonary venous return (HP:0010772)3.30437312
43Abnormality of the prostate (HP:0008775)3.19639348
44Chronic otitis media (HP:0000389)3.19196725
45Bronchitis (HP:0012387)3.12795595
46IgM deficiency (HP:0002850)3.10050932
47Recurrent otitis media (HP:0000403)3.04531951
48IgG deficiency (HP:0004315)3.02619642
49Hypochromic microcytic anemia (HP:0004840)2.97894353
50Chromsome breakage (HP:0040012)2.93282867
51Abnormality of the pulmonary veins (HP:0011718)2.92569206
52Recurrent pneumonia (HP:0006532)2.92356831
53Absent/shortened dynein arms (HP:0200106)2.87704102
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.87704102
55Impulsivity (HP:0100710)2.83238665
56Sepsis (HP:0100806)2.78470062
57Abnormal ciliary motility (HP:0012262)2.70316216
58Dialeptic seizures (HP:0011146)2.65763650
59Limb hypertonia (HP:0002509)2.65573414
60Recurrent fungal infections (HP:0002841)2.62938506
61Septo-optic dysplasia (HP:0100842)2.60300761
62Abnormality of the peritoneum (HP:0002585)2.59842202
63Hepatoblastoma (HP:0002884)2.57521104
64Bile duct proliferation (HP:0001408)2.56807595
65Abnormal biliary tract physiology (HP:0012439)2.56807595
66Abnormality of the fovea (HP:0000493)2.56010753
67Generalized tonic-clonic seizures (HP:0002069)2.55363120
68Abnormality of T cell physiology (HP:0011840)2.51532589
69Abnormality of T cells (HP:0002843)2.50923582
70Broad-based gait (HP:0002136)2.49828201
71Villous atrophy (HP:0011473)2.49139466
72Abnormality of small intestinal villus morphology (HP:0011472)2.49139466
73Hemiparesis (HP:0001269)2.46878906
74Amblyopia (HP:0000646)2.45084640
75Pendular nystagmus (HP:0012043)2.44442758
76Duplication of thumb phalanx (HP:0009942)2.42260237
77Increased IgE level (HP:0003212)2.42025163
78Atonic seizures (HP:0010819)2.37334147
79Protruding tongue (HP:0010808)2.36438835
80Hepatitis (HP:0012115)2.35651832
81Spontaneous hematomas (HP:0007420)2.33687431
82T lymphocytopenia (HP:0005403)2.33469934
83White forelock (HP:0002211)2.32153000
84Reduced antithrombin III activity (HP:0001976)2.31976929
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25704979
86Decreased central vision (HP:0007663)2.24417723
87Recurrent skin infections (HP:0001581)2.21828160
88Aplasia/Hypoplasia of the thymus (HP:0010515)2.21466120
89Nephroblastoma (Wilms tumor) (HP:0002667)2.20283142
903-Methylglutaconic aciduria (HP:0003535)2.19899592
91Partial duplication of thumb phalanx (HP:0009944)2.18567885
92Osteomalacia (HP:0002749)2.18546211
93Upper limb muscle weakness (HP:0003484)2.18190892
94Embryonal renal neoplasm (HP:0011794)2.17465117
95Parakeratosis (HP:0001036)2.15826218
96Atelectasis (HP:0100750)2.14809200
97Abnormality of male internal genitalia (HP:0000022)2.12679576
98Preauricular pit (HP:0004467)2.10496879
99Periauricular skin pits (HP:0100277)2.10496879
100Congenital stationary night blindness (HP:0007642)2.10252219
101Medial flaring of the eyebrow (HP:0010747)2.10107245
102Deep palmar crease (HP:0006191)2.09224731
103Skin rash (HP:0000988)2.08469439
104Recurrent bacterial skin infections (HP:0005406)2.06941645
105Chronic hepatic failure (HP:0100626)2.06090140
106Poikiloderma (HP:0001029)2.04232540
107Gaze-evoked nystagmus (HP:0000640)2.04150403
108Absent speech (HP:0001344)2.03041955
109Lymphedema (HP:0001004)2.02802620
110Absence seizures (HP:0002121)2.01812468
111Microvesicular hepatic steatosis (HP:0001414)2.00375704
112Gastrointestinal stroma tumor (HP:0100723)11.0423210
113Patchy hypopigmentation of hair (HP:0011365)1.99909377
114Dysdiadochokinesis (HP:0002075)1.99219482
115Abnormality of the pleura (HP:0002103)1.99135005
116Cutaneous melanoma (HP:0012056)1.98787423
117Medulloblastoma (HP:0002885)1.96813703
118Obstructive lung disease (HP:0006536)1.96171607
119Chronic obstructive pulmonary disease (HP:0006510)1.96171607
120Anophthalmia (HP:0000528)1.96083586
121Sensory axonal neuropathy (HP:0003390)1.95432014
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95207858
123Optic nerve hypoplasia (HP:0000609)1.94740467
124Abnormality of T cell number (HP:0011839)1.94298684
125Nasolacrimal duct obstruction (HP:0000579)1.93031564
126Blue irides (HP:0000635)1.92577527
127Horizontal nystagmus (HP:0000666)1.90952095
128Abnormal respiratory motile cilium physiology (HP:0012261)1.90717815
129Inability to walk (HP:0002540)1.89760599
130Basal cell carcinoma (HP:0002671)1.89347304
131Fetal akinesia sequence (HP:0001989)1.87336953
132Abnormal respiratory motile cilium morphology (HP:0005938)1.87079491
133Abnormal respiratory epithelium morphology (HP:0012253)1.87079491
134Deeply set eye (HP:0000490)1.87006128
135Supernumerary spleens (HP:0009799)1.87002600
136Squamous cell carcinoma (HP:0002860)1.86440876
137Abnormality of the lacrimal duct (HP:0011481)1.86343433
138Annular pancreas (HP:0001734)1.85717588
139Dyschromatopsia (HP:0007641)1.84412676
140Fair hair (HP:0002286)1.84294525
141Aplasia/Hypoplasia of the macula (HP:0008059)1.84264589
142Gait imbalance (HP:0002141)1.83535626
143Torticollis (HP:0000473)1.83450413
144Abnormality of chromosome stability (HP:0003220)1.80604977
145Neutropenia (HP:0001875)1.79594205
146Distal lower limb amyotrophy (HP:0008944)1.79430484
147Generalized hypopigmentation of hair (HP:0011358)1.79049977
148Abnormal foot bone ossification (HP:0010675)1.78856395
149Status epilepticus (HP:0002133)1.78845853
150Tented upper lip vermilion (HP:0010804)1.77916535
151Split foot (HP:0001839)1.77403491
152Rhabdomyosarcoma (HP:0002859)1.77215186
153Recurrent abscess formation (HP:0002722)1.76279684
154Progressive external ophthalmoplegia (HP:0000590)1.75768323
155Cheilitis (HP:0100825)1.75034707
156Aplasia cutis congenita (HP:0001057)1.74775932
157Congenital primary aphakia (HP:0007707)1.74761214
158Scanning speech (HP:0002168)1.74099394
159Abnormal EKG (HP:0003115)1.74037776
160Skin ulcer (HP:0200042)1.73817933
161Nephrogenic diabetes insipidus (HP:0009806)1.73681991
162Abnormality of the thymus (HP:0000777)1.72663815
163Arthralgia (HP:0002829)1.72304673
164Abnormality of the fingertips (HP:0001211)1.70395730
165Iris hypopigmentation (HP:0007730)1.69168091
166Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68587669
167Elevated hepatic transaminases (HP:0002910)1.68310535
168Abnormality of the pupil (HP:0000615)1.67458034
169Pili torti (HP:0003777)1.66799345
170Limb dystonia (HP:0002451)1.66599128
171Congenital sensorineural hearing impairment (HP:0008527)1.66160655
172Stereotypic behavior (HP:0000733)1.65947602
173Type I transferrin isoform profile (HP:0003642)1.64813604
174Increased IgM level (HP:0003496)1.64044792
175Cafe-au-lait spot (HP:0000957)1.63876847
176Reticulocytopenia (HP:0001896)1.63325703
177Exotropia (HP:0000577)1.63182676
178Rib fusion (HP:0000902)1.63126156
179Chest pain (HP:0100749)1.63059517
180Corneal erosion (HP:0200020)1.62350386
181Partial duplication of the phalanx of hand (HP:0009999)1.62206016
182Congenital hepatic fibrosis (HP:0002612)1.62161276
183Progressive cerebellar ataxia (HP:0002073)1.61954900
184Bifid tongue (HP:0010297)1.61878608
185Abnormality of DNA repair (HP:0003254)1.61397082
186Abnormality of the nasolacrimal system (HP:0000614)1.61056937
187Cubitus valgus (HP:0002967)1.58622599
188Eczematoid dermatitis (HP:0000976)1.57844228
189Slow-growing hair (HP:0002217)1.56526789
190Abnormality of hair growth rate (HP:0011363)1.56526789
191Follicular hyperkeratosis (HP:0007502)1.53750855
192Menstrual irregularities (HP:0000858)1.52542539
193Dehydration (HP:0001944)1.51314365
194Neoplasm of striated muscle (HP:0009728)1.49867584
195Agitation (HP:0000713)1.48608131
196Entropion (HP:0000621)1.47905146
197Abnormality of chromosome segregation (HP:0002916)1.46080660
198Abnormal hair laboratory examination (HP:0003328)1.45261283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN18.28148675
2MAP4K16.10129740
3EPHA45.46691814
4CASK3.81296326
5JAK33.56593023
6MAP3K103.32329746
7ADRBK23.20088971
8PIK3CG2.97238665
9NTRK32.91306017
10ITK2.76254889
11BTK2.70235779
12TNIK2.58647438
13GRK52.51445737
14SYK2.36895274
15PRPF4B2.34962773
16GRK12.32200125
17MST42.16322818
18TEC2.16231558
19NEK92.10343305
20GRK71.95481176
21RIPK41.85867812
22NTRK21.81313519
23SIK31.77115766
24MAP2K71.71674040
25MAP3K131.67409598
26MAPK71.67349073
27INSRR1.66108218
28MUSK1.64207858
29STK391.56929208
30LYN1.52588376
31NEK61.46634286
32AKT31.41638471
33BMPR21.39601706
34TYK21.37244689
35PINK11.30060544
36ARAF1.27404498
37IKBKE1.25135053
38DAPK21.25053264
39TYRO31.23089031
40FES1.22582438
41TAOK21.21238155
42SMG11.19079316
43CDK121.15685382
44SGK21.09124594
45MAP2K41.08410922
46PASK1.07261279
47MARK21.07212901
48TNK21.06942672
49SIK21.06734262
50NTRK11.05808871
51SGK4941.05452506
52SGK2231.05452506
53GRK61.02217044
54MAP3K141.01691539
55CAMK41.01171260
56PKN11.00964311
57CDK41.00135011
58WNK10.90079890
59BCR0.89513973
60LCK0.87817919
61MAPK130.87567817
62PRKCG0.87434866
63MARK10.86651009
64MATK0.86214512
65IRAK40.86096615
66YES10.84181960
67PRKCE0.83139351
68MAPK110.82193479
69CDK50.81390386
70STK100.80840429
71LRRK20.80797608
72CAMK2A0.80297746
73EIF2AK20.80074817
74ZAK0.78821011
75MAP2K60.76990078
76KSR10.76886619
77IRAK20.76870684
78CAMK1G0.76599771
79PRKD20.75458359
80TESK20.75277845
81ADRBK10.74989360
82IRAK30.74658656
83SCYL20.74132870
84EEF2K0.74009567
85TXK0.73747382
86TRIB30.72972425
87MAP3K120.72502849
88BRAF0.72475437
89BRD40.71613539
90CAMK10.71242122
91IKBKB0.71171792
92CAMKK20.69834334
93PLK20.69359453
94MINK10.69043636
95EIF2AK30.68639698
96MAP3K40.68628209
97BRSK20.68524419
98MAP3K90.66834604
99MOS0.66526702
100MAP2K30.66025842
101CAMK1D0.65177041
102SGK10.65166835
103JAK10.65050252
104OXSR10.64973648
105BLK0.63422685
106FGFR40.62183003
107PDK10.61698389
108DYRK1A0.58997672
109ABL10.58997011
110MAP2K20.58932503
111OBSCN0.58227438
112PRKACA0.56750602
113PRKCH0.56641033
114HCK0.56339303
115CDK30.55956115
116CAMK2B0.55139469
117KIT0.55109451
118TAF10.54539367
119SGK30.53794260
120RPS6KA40.51055063
121NEK20.49901196
122MAPK120.49822715
123STK380.48890877
124PRKCQ0.47870890
125CDC42BPA0.46327313
126PAK60.44859816
127ATR0.44357810
128INSR0.44239724
129CLK10.43259063
130CDK80.42869808
131BMPR1B0.42339227
132PRKG10.42302787
133MAP3K70.41899760
134FYN0.41805794
135MAP3K10.41669884
136CAMKK10.41467121
137PNCK0.40884112
138MAP3K80.39640647
139MAPK40.38996122
140PRKCD0.38744686
141CDK190.38063848
142CSF1R0.37411087
143EPHA20.36687467
144IRAK10.36344711
145TGFBR20.35439691
146PRKCI0.35358180
147CCNB10.34982664
148SIK10.34730558
149STK110.34507633
150CAMK2G0.34408016
151PRKG20.34025785
152CSNK1A10.33326232
153WNK30.33161787
154FGR0.29314900
155PRKD10.29209439
156FGFR30.28121971
157TBK10.27731640
158CSK0.24875944
159KSR20.24251949
160BUB10.20421643
161CHUK0.20307426
162HIPK20.19558184
163CDC70.18582835
164MAP2K10.17141101
165RPS6KB20.15464243
166WEE10.15460688
167CDK90.13645868
168CHEK10.13343410
169MARK30.12963763
170RPS6KC10.12248077

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046625.88765803
2Primary immunodeficiency_Homo sapiens_hsa053404.52515206
3Nicotine addiction_Homo sapiens_hsa050333.83515629
4Asthma_Homo sapiens_hsa053103.70762898
5Olfactory transduction_Homo sapiens_hsa047403.02639842
6Morphine addiction_Homo sapiens_hsa050322.96666317
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.89369936
8GABAergic synapse_Homo sapiens_hsa047272.79463264
9Glutamatergic synapse_Homo sapiens_hsa047242.61672831
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.54361461
11Hematopoietic cell lineage_Homo sapiens_hsa046402.54063651
12Circadian entrainment_Homo sapiens_hsa047132.42995075
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.41408657
14Base excision repair_Homo sapiens_hsa034102.38610521
15Taste transduction_Homo sapiens_hsa047422.34967680
16Serotonergic synapse_Homo sapiens_hsa047262.33028722
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.26362277
18Leishmaniasis_Homo sapiens_hsa051402.21226712
19Antigen processing and presentation_Homo sapiens_hsa046122.12923743
20Cocaine addiction_Homo sapiens_hsa050302.12428874
21Viral myocarditis_Homo sapiens_hsa054162.06837602
22Amphetamine addiction_Homo sapiens_hsa050312.03936810
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.97084261
24Calcium signaling pathway_Homo sapiens_hsa040201.92952863
25Vitamin B6 metabolism_Homo sapiens_hsa007501.86542828
26Synaptic vesicle cycle_Homo sapiens_hsa047211.85673629
27Salivary secretion_Homo sapiens_hsa049701.83407064
28Herpes simplex infection_Homo sapiens_hsa051681.82985041
29Staphylococcus aureus infection_Homo sapiens_hsa051501.78436935
30Dopaminergic synapse_Homo sapiens_hsa047281.68993292
31Phototransduction_Homo sapiens_hsa047441.65176042
32Influenza A_Homo sapiens_hsa051641.65081130
33Toxoplasmosis_Homo sapiens_hsa051451.63406939
34Long-term potentiation_Homo sapiens_hsa047201.62717349
35Renin secretion_Homo sapiens_hsa049241.59941326
36Cholinergic synapse_Homo sapiens_hsa047251.57556897
37Long-term depression_Homo sapiens_hsa047301.44101871
38Measles_Homo sapiens_hsa051621.43635970
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40480221
40Tuberculosis_Homo sapiens_hsa051521.37197563
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36624660
42Insulin secretion_Homo sapiens_hsa049111.35774077
43Mismatch repair_Homo sapiens_hsa034301.32611826
44Collecting duct acid secretion_Homo sapiens_hsa049661.32397764
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29971920
46Oxytocin signaling pathway_Homo sapiens_hsa049211.29077899
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28729073
48DNA replication_Homo sapiens_hsa030301.27423176
49cAMP signaling pathway_Homo sapiens_hsa040241.25974371
50Axon guidance_Homo sapiens_hsa043601.24072144
51Epstein-Barr virus infection_Homo sapiens_hsa051691.23431709
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21781779
53Arachidonic acid metabolism_Homo sapiens_hsa005901.19422558
54T cell receptor signaling pathway_Homo sapiens_hsa046601.12639300
55Vascular smooth muscle contraction_Homo sapiens_hsa042701.11077149
56Osteoclast differentiation_Homo sapiens_hsa043801.06346432
57Ether lipid metabolism_Homo sapiens_hsa005651.06204763
58African trypanosomiasis_Homo sapiens_hsa051431.05374333
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05143836
60Ovarian steroidogenesis_Homo sapiens_hsa049131.04645369
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04184034
62Type I diabetes mellitus_Homo sapiens_hsa049401.04019810
63HTLV-I infection_Homo sapiens_hsa051661.03742143
64Notch signaling pathway_Homo sapiens_hsa043301.03659067
65Hepatitis B_Homo sapiens_hsa051611.02039830
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98698454
67GnRH signaling pathway_Homo sapiens_hsa049120.93603209
68Sphingolipid metabolism_Homo sapiens_hsa006000.93348883
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91435722
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90914529
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90471134
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89941006
73Linoleic acid metabolism_Homo sapiens_hsa005910.89180055
74Hepatitis C_Homo sapiens_hsa051600.86945236
75Circadian rhythm_Homo sapiens_hsa047100.85757213
76Systemic lupus erythematosus_Homo sapiens_hsa053220.84945848
77Chronic myeloid leukemia_Homo sapiens_hsa052200.84737405
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.82808392
79Gastric acid secretion_Homo sapiens_hsa049710.81797082
80Non-small cell lung cancer_Homo sapiens_hsa052230.81281323
81Ras signaling pathway_Homo sapiens_hsa040140.79685954
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77947747
83Viral carcinogenesis_Homo sapiens_hsa052030.77805744
84Homologous recombination_Homo sapiens_hsa034400.76913870
85Rheumatoid arthritis_Homo sapiens_hsa053230.76289632
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75061473
87Gap junction_Homo sapiens_hsa045400.72714030
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71841834
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.71358400
90Apoptosis_Homo sapiens_hsa042100.71101357
91Melanogenesis_Homo sapiens_hsa049160.70527439
92Acute myeloid leukemia_Homo sapiens_hsa052210.70069623
93Prostate cancer_Homo sapiens_hsa052150.68812539
94Pancreatic cancer_Homo sapiens_hsa052120.68234523
95Rap1 signaling pathway_Homo sapiens_hsa040150.68180938
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.67772941
97Graft-versus-host disease_Homo sapiens_hsa053320.66954751
98Cardiac muscle contraction_Homo sapiens_hsa042600.66776063
99Fanconi anemia pathway_Homo sapiens_hsa034600.66019627
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65415871
101Autoimmune thyroid disease_Homo sapiens_hsa053200.65045405
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63007093
103ErbB signaling pathway_Homo sapiens_hsa040120.62444312
104ABC transporters_Homo sapiens_hsa020100.61045436
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59054955
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58634467
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58270705
108Dilated cardiomyopathy_Homo sapiens_hsa054140.57696935
109Malaria_Homo sapiens_hsa051440.56611124
110Nucleotide excision repair_Homo sapiens_hsa034200.56255379
111Shigellosis_Homo sapiens_hsa051310.54814494
112TNF signaling pathway_Homo sapiens_hsa046680.54713544
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53827049
114mRNA surveillance pathway_Homo sapiens_hsa030150.53662011
115Dorso-ventral axis formation_Homo sapiens_hsa043200.53608403
116Platelet activation_Homo sapiens_hsa046110.52747401
117Prolactin signaling pathway_Homo sapiens_hsa049170.52527787
118Small cell lung cancer_Homo sapiens_hsa052220.51845805
119Choline metabolism in cancer_Homo sapiens_hsa052310.51501507
120Renal cell carcinoma_Homo sapiens_hsa052110.50548233
121Fructose and mannose metabolism_Homo sapiens_hsa000510.50425481
122Histidine metabolism_Homo sapiens_hsa003400.49596675
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48894801
124Inositol phosphate metabolism_Homo sapiens_hsa005620.46759680
125MAPK signaling pathway_Homo sapiens_hsa040100.45756506
126Wnt signaling pathway_Homo sapiens_hsa043100.45194187
127Phagosome_Homo sapiens_hsa041450.45095723
128VEGF signaling pathway_Homo sapiens_hsa043700.44298373
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43529184
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43527590
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.43311511
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42001235
133Chemokine signaling pathway_Homo sapiens_hsa040620.41747748
134Regulation of autophagy_Homo sapiens_hsa041400.41702907
135Complement and coagulation cascades_Homo sapiens_hsa046100.39529676
136Retinol metabolism_Homo sapiens_hsa008300.39445802
137Pertussis_Homo sapiens_hsa051330.39317064
138FoxO signaling pathway_Homo sapiens_hsa040680.39172878
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38738219
140beta-Alanine metabolism_Homo sapiens_hsa004100.38616242
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38329996
142Allograft rejection_Homo sapiens_hsa053300.37709191
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37697384
144Alcoholism_Homo sapiens_hsa050340.37532881
145Cell cycle_Homo sapiens_hsa041100.37527440
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36590798
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36194821
148Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36016959
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.35283720
150Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35087955
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.34532716
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34311950
153Prion diseases_Homo sapiens_hsa050200.33478211
154Cyanoamino acid metabolism_Homo sapiens_hsa004600.33466454
155mTOR signaling pathway_Homo sapiens_hsa041500.32880279
156Colorectal cancer_Homo sapiens_hsa052100.32118252
157Glioma_Homo sapiens_hsa052140.31991185
158Non-homologous end-joining_Homo sapiens_hsa034500.31839557
159Leukocyte transendothelial migration_Homo sapiens_hsa046700.31755184
160Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.31463033
161Basal cell carcinoma_Homo sapiens_hsa052170.30964784
162Alzheimers disease_Homo sapiens_hsa050100.30879265
163MicroRNAs in cancer_Homo sapiens_hsa052060.30363832
164RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29287679
165Vitamin digestion and absorption_Homo sapiens_hsa049770.29276841
166Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28310619
167Glycerophospholipid metabolism_Homo sapiens_hsa005640.27240253
168Insulin signaling pathway_Homo sapiens_hsa049100.26736048
169Butanoate metabolism_Homo sapiens_hsa006500.26217107
170Melanoma_Homo sapiens_hsa052180.25890510
171HIF-1 signaling pathway_Homo sapiens_hsa040660.25699905
172Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24572290
173Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24350696
174Pancreatic secretion_Homo sapiens_hsa049720.23647936
175Endometrial cancer_Homo sapiens_hsa052130.21375222
176Basal transcription factors_Homo sapiens_hsa030220.19070009
177NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17854954
178p53 signaling pathway_Homo sapiens_hsa041150.16622145

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