SERPINB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.17979106
2positive regulation of gamma-delta T cell activation (GO:0046645)5.01523737
3response to peptidoglycan (GO:0032494)4.70158097
4cellular extravasation (GO:0045123)4.07657709
5positive regulation of B cell differentiation (GO:0045579)4.04645915
6detection of other organism (GO:0098543)3.97982789
7immunoglobulin mediated immune response (GO:0016064)3.96754804
8antigen processing and presentation of endogenous antigen (GO:0019883)3.92543918
9detection of bacterium (GO:0016045)3.91673260
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.91020494
11negative regulation of erythrocyte differentiation (GO:0045647)3.77361988
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70585214
13positive regulation by symbiont of host defense response (GO:0052509)3.58908544
14modulation by symbiont of host defense response (GO:0052031)3.58908544
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.58908544
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.58908544
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.58908544
18modulation by symbiont of host immune response (GO:0052553)3.58908544
19microglial cell activation (GO:0001774)3.57827843
20negative regulation of interleukin-12 production (GO:0032695)3.51314848
21regulation of gamma-delta T cell activation (GO:0046643)3.50458835
22regulation of mast cell degranulation (GO:0043304)3.49317447
23neutrophil activation (GO:0042119)3.47347373
24negative regulation of cell killing (GO:0031342)3.45837995
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45837995
26regulation of B cell receptor signaling pathway (GO:0050855)3.41946149
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.40590133
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39605458
29neutrophil mediated immunity (GO:0002446)3.30759220
30macrophage activation involved in immune response (GO:0002281)3.30042300
31regulation of gamma-delta T cell differentiation (GO:0045586)3.25804788
32granulocyte activation (GO:0036230)3.24981882
33regulation of mast cell activation involved in immune response (GO:0033006)3.21383536
34B cell mediated immunity (GO:0019724)3.17511190
35regulation of myeloid leukocyte mediated immunity (GO:0002886)3.16098207
36defense response to protozoan (GO:0042832)3.12305668
37myeloid cell activation involved in immune response (GO:0002275)3.11233943
38response to muramyl dipeptide (GO:0032495)3.11232156
39response to protozoan (GO:0001562)3.08414846
40modulation of growth of symbiont involved in interaction with host (GO:0044144)3.07578176
41regulation of growth of symbiont in host (GO:0044126)3.07578176
42negative regulation of growth of symbiont in host (GO:0044130)3.07578176
43negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.07578176
44detection of external biotic stimulus (GO:0098581)3.06713329
45autophagic vacuole fusion (GO:0000046)3.05152575
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04923482
47positive regulation of antigen processing and presentation (GO:0002579)3.04253978
48regulation of B cell differentiation (GO:0045577)3.03421840
49leukocyte aggregation (GO:0070486)3.00692818
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.99758206
51response to host immune response (GO:0052572)2.99758206
52macrophage activation (GO:0042116)2.99715174
53positive regulation of mast cell activation (GO:0033005)2.98399155
54mature B cell differentiation involved in immune response (GO:0002313)2.97792490
55regulation of leukocyte degranulation (GO:0043300)2.97304108
56regulation of antigen processing and presentation (GO:0002577)2.96913489
57regulation of mast cell activation (GO:0033003)2.95444217
58positive regulation of mast cell activation involved in immune response (GO:0033008)2.93980328
59positive regulation of mast cell degranulation (GO:0043306)2.93980328
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.93891679
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93839343
62definitive hemopoiesis (GO:0060216)2.93373149
63interferon-gamma-mediated signaling pathway (GO:0060333)2.92215880
64positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91890069
65regulation of T-helper 1 cell differentiation (GO:0045625)2.91028531
66thrombin receptor signaling pathway (GO:0070493)2.89215173
67lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88930436
68leukocyte degranulation (GO:0043299)2.84123408
69positive regulation of granulocyte differentiation (GO:0030854)2.83630553
70positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82791223
71B cell receptor signaling pathway (GO:0050853)2.81572195
72respiratory burst (GO:0045730)2.81460632
73negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.79753997
74cellular response to type I interferon (GO:0071357)2.77318473
75type I interferon signaling pathway (GO:0060337)2.77318473
76regulation of chemokine biosynthetic process (GO:0045073)2.77281466
77response to type I interferon (GO:0034340)2.75294890
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74710588
79detection of biotic stimulus (GO:0009595)2.72751616
80germinal center formation (GO:0002467)2.72193389
81negative regulation of T cell mediated immunity (GO:0002710)2.72048604
82regulation of hypersensitivity (GO:0002883)2.68898719
83response to host defenses (GO:0052200)2.68735617
84response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68735617
85response to host (GO:0075136)2.68735617
86negative regulation of interleukin-8 production (GO:0032717)2.66711790
87negative regulation of lymphocyte mediated immunity (GO:0002707)2.65439110
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.64831772
89positive regulation of interleukin-17 production (GO:0032740)2.63760340
90positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.63568965
91response to interferon-beta (GO:0035456)2.62798944
92positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.62245723
93regulation of interleukin-8 biosynthetic process (GO:0045414)2.60891403
94positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.60130996
95myeloid leukocyte mediated immunity (GO:0002444)2.59670591
96regulation of interferon-beta biosynthetic process (GO:0045357)2.57844125
97regulation of interferon-alpha production (GO:0032647)2.56849010
98T-helper 1 type immune response (GO:0042088)2.56743468
99positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.55449340
100cellular response to exogenous dsRNA (GO:0071360)2.54597694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.23613567
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.10645197
3GATA1_22025678_ChIP-Seq_K562_Human3.77709685
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.60698725
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.57987902
6SCL_19346495_ChIP-Seq_HPC-7_Human3.54782281
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.37952947
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88571603
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87807298
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.85287242
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.82598474
12VDR_24763502_ChIP-Seq_THP-1_Human2.68159213
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67750411
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67593659
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61455585
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60843523
17* SPI1_23547873_ChIP-Seq_NB4_Human2.59338334
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.53851582
19VDR_21846776_ChIP-Seq_THP-1_Human2.50683040
20MYB_26560356_Chip-Seq_TH2_Human2.35836719
21RUNX_20019798_ChIP-Seq_JUKART_Human2.24536296
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24213549
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18074506
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16044429
25SPI1_23127762_ChIP-Seq_K562_Human2.10030733
26* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.09958223
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.08954109
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07613893
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.04219579
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97551670
31LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.91862200
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86992778
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.82938736
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82513412
35MAF_26560356_Chip-Seq_TH1_Human1.81702549
36MYB_26560356_Chip-Seq_TH1_Human1.78583868
37GATA1_19941826_ChIP-Seq_K562_Human1.77534045
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.77189721
39GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.74027841
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71900767
41UTX_26944678_Chip-Seq_JUKART_Human1.69619409
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67363043
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66724305
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64173366
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63794174
46GATA2_22383799_ChIP-Seq_G1ME_Mouse1.62920494
47VDR_24787735_ChIP-Seq_THP-1_Human1.62230703
48GATA3_27048872_Chip-Seq_THYMUS_Human1.58156685
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.54763440
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.51285527
51* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50968877
52SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43908582
53GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40075703
54GATA3_26560356_Chip-Seq_TH2_Human1.37600925
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36021046
56MYC_22102868_ChIP-Seq_BL_Human1.34447649
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33080751
58GATA2_19941826_ChIP-Seq_K562_Human1.31691755
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24310219
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22446717
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21143619
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20355584
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20257965
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19255163
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18309775
66TCF7_22412390_ChIP-Seq_EML_Mouse1.18111708
67CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17626421
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17619227
69MAF_26560356_Chip-Seq_TH2_Human1.17258646
70* BCL6_27268052_Chip-Seq_Bcells_Human1.16342332
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15868469
72PU_27001747_Chip-Seq_BMDM_Mouse1.13436655
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11265466
74STAT1_20625510_ChIP-Seq_HELA_Human1.09627644
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07627874
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07111017
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06245148
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03567675
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03251424
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01790935
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99655794
82* BCOR_27268052_Chip-Seq_Bcells_Human0.98926600
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96926168
84SPI1_20517297_ChIP-Seq_HL60_Human0.95411887
85PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93482831
86* P300_27268052_Chip-Seq_Bcells_Human0.92073243
87NCOR1_26117541_ChIP-Seq_K562_Human0.91163838
88CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88446851
89RXR_22158963_ChIP-Seq_LIVER_Mouse0.85521879
90ELF1_20517297_ChIP-Seq_JURKAT_Human0.84825848
91PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84145149
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.83214955
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82279568
94HOXB4_20404135_ChIP-ChIP_EML_Mouse0.81682465
95PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81135137
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79778438
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76434845
98* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76151663
99BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.73563757
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73022663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.92036407
2MP0003724_increased_susceptibility_to3.91841259
3MP0001835_abnormal_antigen_presentation3.58610694
4MP0003436_decreased_susceptibility_to3.33956397
5MP0005464_abnormal_platelet_physiology3.08183941
6MP0006082_CNS_inflammation2.80380659
7MP0009785_altered_susceptibility_to2.73704150
8MP0002419_abnormal_innate_immunity2.72077650
9MP0002148_abnormal_hypersensitivity_rea2.69796857
10MP0005025_abnormal_response_to2.69664169
11MP0001545_abnormal_hematopoietic_system2.60518992
12MP0005397_hematopoietic_system_phenotyp2.60518992
13MP0005000_abnormal_immune_tolerance2.59283034
14MP0000465_gastrointestinal_hemorrhage2.49709111
15MP0001800_abnormal_humoral_immune2.42085649
16MP0005387_immune_system_phenotype2.26506519
17MP0001790_abnormal_immune_system2.26506519
18MP0005671_abnormal_response_to2.26147479
19MP0002452_abnormal_antigen_presenting2.25686386
20MP0002723_abnormal_immune_serum2.21984438
21MP0002420_abnormal_adaptive_immunity2.16428359
22MP0010155_abnormal_intestine_physiology2.16108131
23MP0009278_abnormal_bone_marrow2.16096838
24MP0001819_abnormal_immune_cell2.15071406
25MP0000685_abnormal_immune_system2.04904604
26MP0003763_abnormal_thymus_physiology1.97152753
27MP0003806_abnormal_nucleotide_metabolis1.94930384
28MP0003300_gastrointestinal_ulcer1.88827189
29MP0002396_abnormal_hematopoietic_system1.87166679
30MP0001533_abnormal_skeleton_physiology1.81478823
31MP0001845_abnormal_inflammatory_respons1.78278538
32MP0002398_abnormal_bone_marrow1.74118361
33MP0002405_respiratory_system_inflammati1.73619804
34MP0009764_decreased_sensitivity_to1.71008293
35MP0003191_abnormal_cellular_cholesterol1.67153015
36MP0000716_abnormal_immune_system1.66042329
37MP0008004_abnormal_stomach_pH1.59234037
38MP0009333_abnormal_splenocyte_physiolog1.56466039
39MP0005058_abnormal_lysosome_morphology1.54429677
40MP0003172_abnormal_lysosome_physiology1.53645244
41MP0008469_abnormal_protein_level1.52962145
42MP0003075_altered_response_to1.49763369
43MP0004947_skin_inflammation1.49620365
44MP0003656_abnormal_erythrocyte_physiolo1.49497526
45MP0000689_abnormal_spleen_morphology1.48125516
46MP0003866_abnormal_defecation1.45472957
47MP0004808_abnormal_hematopoietic_stem1.43821919
48MP0002722_abnormal_immune_system1.43734331
49MP0005166_decreased_susceptibility_to1.43664315
50MP0002429_abnormal_blood_cell1.41002400
51MP0002132_abnormal_respiratory_system1.39655131
52MP0001663_abnormal_digestive_system1.39127204
53MP0003183_abnormal_peptide_metabolism1.35575693
54MP0001853_heart_inflammation1.23309563
55MP0000858_altered_metastatic_potential1.22600622
56MP0003828_pulmonary_edema1.19565407
57MP0001851_eye_inflammation1.18681983
58MP0009763_increased_sensitivity_to1.14507013
59MP0001873_stomach_inflammation1.12431473
60MP0002166_altered_tumor_susceptibility1.10820972
61MP0002139_abnormal_hepatobiliary_system1.06495416
62MP0000343_altered_response_to1.06434548
63MP0005164_abnormal_response_to0.99855196
64MP0005451_abnormal_body_composition0.94876930
65MP0000703_abnormal_thymus_morphology0.92646080
66MP0009765_abnormal_xenobiotic_induced0.92326109
67MP0009840_abnormal_foam_cell0.92200315
68MP0002998_abnormal_bone_remodeling0.92152107
69MP0002138_abnormal_hepatobiliary_system0.90049253
70MP0002006_tumorigenesis0.89592159
71MP0005310_abnormal_salivary_gland0.86867941
72MP0005381_digestive/alimentary_phenotyp0.86732361
73MP0005165_increased_susceptibility_to0.84613161
74MP0003448_altered_tumor_morphology0.83355734
75MP0008260_abnormal_autophagy0.82629588
76MP0006054_spinal_hemorrhage0.82405635
77MP0005075_abnormal_melanosome_morpholog0.81336800
78MP0001664_abnormal_digestion0.81122987
79MP0002019_abnormal_tumor_incidence0.80488898
80MP0000490_abnormal_crypts_of0.78741536
81MP0005360_urolithiasis0.77769825
82MP0005390_skeleton_phenotype0.77276260
83MP0000604_amyloidosis0.77019506
84MP0005319_abnormal_enzyme/_coenzyme0.76366903
85MP0004883_abnormal_blood_vessel0.72602245
86MP0000249_abnormal_blood_vessel0.72288092
87MP0005535_abnormal_body_temperature0.71913167
88MP0004147_increased_porphyrin_level0.71444844
89MP0009643_abnormal_urine_homeostasis0.69334249
90MP0001764_abnormal_homeostasis0.68464577
91MP0005085_abnormal_gallbladder_physiolo0.67968978
92MP0005083_abnormal_biliary_tract0.66202432
93MP0005365_abnormal_bile_salt0.65643068
94MP0004510_myositis0.61618742
95MP0000609_abnormal_liver_physiology0.59956911
96MP0000015_abnormal_ear_pigmentation0.59323917
97MP0005376_homeostasis/metabolism_phenot0.58931592
98MP0000681_abnormal_thyroid_gland0.58917736
99MP0002136_abnormal_kidney_physiology0.57899742
100MP0005084_abnormal_gallbladder_morpholo0.56736931

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.85407844
2Myositis (HP:0100614)4.62966672
3Prolonged bleeding time (HP:0003010)4.50586307
4Eczematoid dermatitis (HP:0000976)4.46247795
5Recurrent abscess formation (HP:0002722)4.45707878
6Recurrent bacterial skin infections (HP:0005406)4.40899693
7Stomatitis (HP:0010280)4.20564885
8Petechiae (HP:0000967)4.16682054
9Obstructive lung disease (HP:0006536)3.89611076
10Chronic obstructive pulmonary disease (HP:0006510)3.89611076
11Abnormality of macrophages (HP:0004311)3.85098766
12Orchitis (HP:0100796)3.84085909
13Epistaxis (HP:0000421)3.68641511
14Retrobulbar optic neuritis (HP:0100654)3.53985737
15Optic neuritis (HP:0100653)3.53985737
16Recurrent fungal infections (HP:0002841)3.52748746
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.46822311
18Purpura (HP:0000979)3.46669943
19Thrombocytosis (HP:0001894)3.39551191
20Meningitis (HP:0001287)3.34247829
21Gingival bleeding (HP:0000225)3.29430611
22Recurrent gram-negative bacterial infections (HP:0005420)3.24148309
23Mediastinal lymphadenopathy (HP:0100721)3.19282771
24Recurrent skin infections (HP:0001581)3.11616952
25Vasculitis (HP:0002633)3.03416987
26Granulocytopenia (HP:0001913)2.99641006
27Autoimmune hemolytic anemia (HP:0001890)2.94622342
28Recurrent viral infections (HP:0004429)2.93322807
29Panhypogammaglobulinemia (HP:0003139)2.92187959
30Increased IgE level (HP:0003212)2.91602660
31Autoimmune thrombocytopenia (HP:0001973)2.90977301
32Encephalitis (HP:0002383)2.90348985
33Recurrent cutaneous fungal infections (HP:0011370)2.84823528
34Chronic mucocutaneous candidiasis (HP:0002728)2.84823528
35Urticaria (HP:0001025)2.83791745
36Leukocytosis (HP:0001974)2.83475394
37Chest pain (HP:0100749)2.80667921
38Arterial thrombosis (HP:0004420)2.77323973
39Agammaglobulinemia (HP:0004432)2.75278451
40Pulmonary infiltrates (HP:0002113)2.75068438
41Keratoconjunctivitis sicca (HP:0001097)2.74129637
42Abnormality of glycolipid metabolism (HP:0010969)2.73636071
43Abnormality of liposaccharide metabolism (HP:0010968)2.73636071
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.73636071
45Acute lymphatic leukemia (HP:0006721)2.72981855
46Abnormality of the prostate (HP:0008775)2.70622481
47Abnormality of B cell number (HP:0010975)2.66030652
48Abnormality of iron homeostasis (HP:0011031)2.64103439
49Systemic lupus erythematosus (HP:0002725)2.63660253
50Hemoptysis (HP:0002105)2.63312762
51Cellulitis (HP:0100658)2.61737478
52Hypergammaglobulinemia (HP:0010702)2.61494136
53Gangrene (HP:0100758)2.61219114
54Gastrointestinal infarctions (HP:0005244)2.59523956
55Keratoconjunctivitis (HP:0001096)2.56860199
56Pustule (HP:0200039)2.56040472
57Abnormality of T cell physiology (HP:0011840)2.55543164
58Amyloidosis (HP:0011034)2.55428306
59Increased IgM level (HP:0003496)2.51030557
60Increased serum ferritin (HP:0003281)2.50703679
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.49464706
62Pulmonary embolism (HP:0002204)2.48214889
63Increased cerebral lipofuscin (HP:0011813)2.48081308
64Spontaneous hematomas (HP:0007420)2.44916710
65Eosinophilia (HP:0001880)2.44795710
66Abnormality of T cells (HP:0002843)2.42456089
67Chronic otitis media (HP:0000389)2.40123308
68Gingivitis (HP:0000230)2.39155479
69Inflammation of the large intestine (HP:0002037)2.38982828
70Dysostosis multiplex (HP:0000943)2.38457581
71Episodic fever (HP:0001954)2.37475051
72Gastrointestinal inflammation (HP:0004386)2.36358180
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.34947929
74Abnormal platelet volume (HP:0011876)2.32310790
75Abnormal platelet function (HP:0011869)2.32275374
76Impaired platelet aggregation (HP:0003540)2.32275374
77Abnormality of transition element cation homeostasis (HP:0011030)2.30090064
78Vacuolated lymphocytes (HP:0001922)2.29390209
79Hepatosplenomegaly (HP:0001433)2.28557149
80Skin rash (HP:0000988)2.28408506
81Polyneuropathy (HP:0001271)2.27937356
82Abnormality of T cell number (HP:0011839)2.27301467
83Interstitial pulmonary disease (HP:0006530)2.21481446
84Abnormality of the pleura (HP:0002103)2.20564277
85B lymphocytopenia (HP:0010976)2.19513691
86Thrombophlebitis (HP:0004418)2.17642735
87Menorrhagia (HP:0000132)2.17014660
88Joint swelling (HP:0001386)2.16715365
89Chronic diarrhea (HP:0002028)2.12722009
90Skin ulcer (HP:0200042)2.10034705
91Osteomyelitis (HP:0002754)2.08334984
92Colitis (HP:0002583)2.07750984
93T lymphocytopenia (HP:0005403)2.07739475
94Anorexia (HP:0002039)2.03943304
95Loss of speech (HP:0002371)2.02447775
96Hypertensive crisis (HP:0100735)2.01004437
97Vertigo (HP:0002321)2.00638777
98Abnormality of eosinophils (HP:0001879)1.99573225
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.99520813
100Increased mean platelet volume (HP:0011877)1.98693934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K33.73731796
2RIPK43.28266978
3MAP4K12.95806060
4ERN12.73164067
5JAK32.61408680
6TAOK32.55331037
7MAP3K112.52425609
8TAOK22.50055037
9KIT2.48409089
10MAP3K32.43364982
11FES2.38879875
12TXK2.24363768
13TAOK12.21644472
14TBK12.12766198
15IRAK42.09028575
16TYK22.06429958
17MAP3K142.05006399
18BLK2.02385456
19BTK1.96205802
20ZAP701.92414070
21MKNK21.91451049
22SYK1.88199395
23TEC1.85490533
24MATK1.85459521
25BMPR21.83041799
26IKBKE1.72140785
27GRK61.68519286
28CSK1.64650578
29MKNK11.57745915
30IKBKB1.53741693
31NME21.52582097
32CSF1R1.51466155
33TNK21.44026981
34LYN1.33206165
35MAP3K11.31642744
36TESK21.31489424
37HCK1.31008197
38IRAK31.26024590
39ITK1.24547603
40PRPF4B1.22330089
41LCK1.10613413
42IRAK11.09839296
43ABL21.09430077
44BCKDK1.05358611
45MAP3K50.99480304
46JAK20.99321075
47PIK3CG0.99141093
48MAP3K60.97867438
49JAK10.96726386
50PIM20.89413202
51GRK70.88835429
52KDR0.88380791
53SCYL20.87117337
54MAP2K60.84730645
55PRKCQ0.82667754
56MAP3K130.82229315
57HIPK20.80658749
58FGR0.80567942
59MAP4K20.78461262
60FLT30.71927076
61EPHB10.67438458
62TGFBR20.64725543
63NUAK10.63947469
64TRPM70.63876862
65PRKG20.58626547
66IRAK20.58472762
67ACVR1B0.57822701
68PIM10.52511904
69CDK190.52140040
70DAPK20.51237258
71MAP2K20.51233047
72CDK60.50720554
73PDK10.49051143
74LRRK20.48371766
75ABL10.47503186
76MARK30.46513173
77EPHA30.46118399
78PRKCD0.44028625
79STK100.41033885
80PDPK10.39833044
81FGFR30.38114396
82RPS6KB20.37277802
83FYN0.36089583
84MST40.35064239
85RPS6KC10.34224280
86RPS6KL10.34224280
87ADRBK20.33990682
88MAPK40.33677385
89BMX0.33183537
90MAP3K20.32068356
91RPS6KA60.30447750
92PTK2B0.29611901
93MAPK30.27964929
94IGF1R0.27346478
95DAPK10.26979447
96MAPKAPK20.24707617
97MAPK110.23577044
98TLK10.22560060
99MAP3K70.22481818
100PIK3CA0.21713217

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.34520549
2Allograft rejection_Homo sapiens_hsa053303.12462193
3Leishmaniasis_Homo sapiens_hsa051403.02110790
4Staphylococcus aureus infection_Homo sapiens_hsa051502.92301081
5Graft-versus-host disease_Homo sapiens_hsa053322.87761569
6Autoimmune thyroid disease_Homo sapiens_hsa053202.75631691
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.52995759
8Type I diabetes mellitus_Homo sapiens_hsa049402.38111784
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30744316
10Hematopoietic cell lineage_Homo sapiens_hsa046402.21679837
11Osteoclast differentiation_Homo sapiens_hsa043802.17587914
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99958758
13Primary immunodeficiency_Homo sapiens_hsa053401.95549170
14Other glycan degradation_Homo sapiens_hsa005111.93917630
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.90717199
16Tuberculosis_Homo sapiens_hsa051521.89562480
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89001924
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86564380
19Antigen processing and presentation_Homo sapiens_hsa046121.85889319
20Rheumatoid arthritis_Homo sapiens_hsa053231.76609942
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.73259610
22Malaria_Homo sapiens_hsa051441.63672169
23Legionellosis_Homo sapiens_hsa051341.58349781
24Platelet activation_Homo sapiens_hsa046111.57110561
25B cell receptor signaling pathway_Homo sapiens_hsa046621.56556250
26African trypanosomiasis_Homo sapiens_hsa051431.53940993
27Pertussis_Homo sapiens_hsa051331.53917457
28Influenza A_Homo sapiens_hsa051641.51356181
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47208167
30Toxoplasmosis_Homo sapiens_hsa051451.44361004
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44233738
32Viral myocarditis_Homo sapiens_hsa054161.42031535
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36325380
34Measles_Homo sapiens_hsa051621.34346709
35Herpes simplex infection_Homo sapiens_hsa051681.32125314
36TNF signaling pathway_Homo sapiens_hsa046681.29645476
37Acute myeloid leukemia_Homo sapiens_hsa052211.25789335
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.22102969
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.17952711
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17428939
41Lysosome_Homo sapiens_hsa041421.16267432
42Renin-angiotensin system_Homo sapiens_hsa046141.14788688
43Arachidonic acid metabolism_Homo sapiens_hsa005901.08721329
44Salmonella infection_Homo sapiens_hsa051321.06914678
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05243569
46Phagosome_Homo sapiens_hsa041451.03111139
47Chemokine signaling pathway_Homo sapiens_hsa040621.02671262
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97475339
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95946647
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95356408
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94342506
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89532608
53T cell receptor signaling pathway_Homo sapiens_hsa046600.87562168
54Hepatitis C_Homo sapiens_hsa051600.85267129
55Shigellosis_Homo sapiens_hsa051310.80919098
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80655233
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78189832
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.73358759
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70978607
60Systemic lupus erythematosus_Homo sapiens_hsa053220.70576118
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.68055488
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.67751013
63Sulfur metabolism_Homo sapiens_hsa009200.66088607
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65199462
65Hepatitis B_Homo sapiens_hsa051610.64956160
66Pancreatic secretion_Homo sapiens_hsa049720.61824072
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61009173
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60839003
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60164361
70Glycerolipid metabolism_Homo sapiens_hsa005610.57627101
71* Amoebiasis_Homo sapiens_hsa051460.55629114
72Linoleic acid metabolism_Homo sapiens_hsa005910.55358350
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54698390
74Epstein-Barr virus infection_Homo sapiens_hsa051690.51048509
75Apoptosis_Homo sapiens_hsa042100.50822706
76Chemical carcinogenesis_Homo sapiens_hsa052040.50311983
77Complement and coagulation cascades_Homo sapiens_hsa046100.49290757
78Starch and sucrose metabolism_Homo sapiens_hsa005000.47459573
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.43992776
80Pancreatic cancer_Homo sapiens_hsa052120.43631088
81Fat digestion and absorption_Homo sapiens_hsa049750.42123261
82Peroxisome_Homo sapiens_hsa041460.42013828
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40204004
84Ether lipid metabolism_Homo sapiens_hsa005650.40047399
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38711997
86Pentose phosphate pathway_Homo sapiens_hsa000300.38619232
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38538396
88Tryptophan metabolism_Homo sapiens_hsa003800.37351422
89Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35493232
90Galactose metabolism_Homo sapiens_hsa000520.34948120
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.32891373
92Glutathione metabolism_Homo sapiens_hsa004800.32771369
93Regulation of autophagy_Homo sapiens_hsa041400.32031553
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31440611
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.29770722
96Non-small cell lung cancer_Homo sapiens_hsa052230.29152832
97Prolactin signaling pathway_Homo sapiens_hsa049170.26781331
98Chronic myeloid leukemia_Homo sapiens_hsa052200.26322114
99Vitamin digestion and absorption_Homo sapiens_hsa049770.25478678
100VEGF signaling pathway_Homo sapiens_hsa043700.22836066

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