SERPINB10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the serpin peptidase inhibitor, clade B family and is found in a cluster of other similar genes on chromosome 18. The protein encoded by this gene appears to help control the regulation of protease functions during hematopoiesis. Variations in this gene may increase the risk of prostate cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)9.51494749
2hemidesmosome assembly (GO:0031581)9.09728210
3production of molecular mediator involved in inflammatory response (GO:0002532)6.15944052
4modulation of growth of symbiont involved in interaction with host (GO:0044144)5.92114240
5regulation of growth of symbiont in host (GO:0044126)5.92114240
6negative regulation of growth of symbiont in host (GO:0044130)5.92114240
7negative regulation of growth of symbiont involved in interaction with host (GO:0044146)5.92114240
8detection of other organism (GO:0098543)5.77821863
9lipoxygenase pathway (GO:0019372)5.69632358
10regulation of integrin activation (GO:0033623)5.64461958
11detection of bacterium (GO:0016045)5.59905577
12neutrophil activation involved in immune response (GO:0002283)5.31399242
13fibrinolysis (GO:0042730)5.28116021
14cell wall macromolecule catabolic process (GO:0016998)5.22949143
15cellular extravasation (GO:0045123)5.19801444
16DNA integration (GO:0015074)5.08844819
17desmosome organization (GO:0002934)4.91899716
18disruption of cells of other organism (GO:0044364)4.87521202
19killing of cells of other organism (GO:0031640)4.87521202
20positive regulation by symbiont of host defense response (GO:0052509)4.73847935
21modulation by symbiont of host defense response (GO:0052031)4.73847935
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.73847935
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.73847935
24positive regulation by organism of defense response of other organism involved in symbiotic interact4.73847935
25modulation by symbiont of host immune response (GO:0052553)4.73847935
26innate immune response in mucosa (GO:0002227)4.68560261
27response to peptidoglycan (GO:0032494)4.68314061
28regulation of apoptotic cell clearance (GO:2000425)4.59813728
29cell wall macromolecule metabolic process (GO:0044036)4.50174663
30leukotriene metabolic process (GO:0006691)4.45683976
31detection of external biotic stimulus (GO:0098581)4.40281654
32regulation of dendritic cell antigen processing and presentation (GO:0002604)4.20671286
33cellular response to ethanol (GO:0071361)4.15774522
34mucosal immune response (GO:0002385)4.11833084
35leukocyte aggregation (GO:0070486)4.08581670
36positive regulation of antigen processing and presentation (GO:0002579)4.08409722
37negative regulation of interleukin-8 production (GO:0032717)4.05204810
38organ or tissue specific immune response (GO:0002251)3.99566249
39regulation of lymphocyte chemotaxis (GO:1901623)3.99469007
40detection of molecule of bacterial origin (GO:0032490)3.96210798
41regulation of interleukin-8 biosynthetic process (GO:0045414)3.79586368
42detection of biotic stimulus (GO:0009595)3.78387677
43neutrophil activation (GO:0042119)3.72463359
44antibacterial humoral response (GO:0019731)3.71582297
45germinal center formation (GO:0002467)3.70752901
46eosinophil migration (GO:0072677)3.70006198
47microglial cell activation (GO:0001774)3.66044196
48respiratory burst (GO:0045730)3.65648455
49regulation of B cell receptor signaling pathway (GO:0050855)3.65525658
50positive regulation of B cell differentiation (GO:0045579)3.65238099
51cell-substrate junction assembly (GO:0007044)3.65122586
52leukotriene biosynthetic process (GO:0019370)3.63631880
53regulation of antigen processing and presentation (GO:0002577)3.58013547
54viral transcription (GO:0019083)3.56538691
55negative regulation of granulocyte differentiation (GO:0030853)3.55526717
56glucosamine-containing compound catabolic process (GO:1901072)3.54495834
57positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.53834972
58response to host immune response (GO:0052572)3.49356654
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.49356654
60granulocyte activation (GO:0036230)3.46975020
61indole-containing compound catabolic process (GO:0042436)3.42257939
62indolalkylamine catabolic process (GO:0046218)3.42257939
63tryptophan catabolic process (GO:0006569)3.42257939
64neutrophil mediated immunity (GO:0002446)3.41927841
65superoxide anion generation (GO:0042554)3.41400702
66leukocyte migration involved in inflammatory response (GO:0002523)3.40136563
67macrophage activation involved in immune response (GO:0002281)3.39460086
68ribosomal small subunit assembly (GO:0000028)3.37408267
69translational termination (GO:0006415)3.36491768
70antimicrobial humoral response (GO:0019730)3.34511001
71negative regulation of interleukin-12 production (GO:0032695)3.32490542
72eosinophil chemotaxis (GO:0048245)3.29122590
73regulation of interferon-beta biosynthetic process (GO:0045357)3.28709671
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.27664478
75macrophage differentiation (GO:0030225)3.27379720
76indolalkylamine metabolic process (GO:0006586)3.25864805
77response to host (GO:0075136)3.25466560
78response to host defenses (GO:0052200)3.25466560
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.25466560
80defense response to fungus (GO:0050832)3.21547052
81regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.21096084
82regulation of MHC class II biosynthetic process (GO:0045346)3.17922163
83regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.16684563
84response to muramyl dipeptide (GO:0032495)3.16630377
85regulation of chemokine biosynthetic process (GO:0045073)3.16284358
86regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.15334272
87hydrogen peroxide biosynthetic process (GO:0050665)3.14495454
88regulation of B cell differentiation (GO:0045577)3.13819290
89regulation of mast cell degranulation (GO:0043304)3.12933797
90myeloid cell activation involved in immune response (GO:0002275)3.12022521
91regulation of mast cell activation (GO:0033003)3.10723570
92L-fucose catabolic process (GO:0042355)3.10118278
93fucose catabolic process (GO:0019317)3.10118278
94L-fucose metabolic process (GO:0042354)3.10118278
95ribosomal small subunit biogenesis (GO:0042274)3.09297073
96T cell migration (GO:0072678)3.08155919
97defense response to Gram-positive bacterium (GO:0050830)3.06765546
98regulation of mast cell activation involved in immune response (GO:0033006)3.06013434
99kynurenine metabolic process (GO:0070189)3.05243250
100mast cell activation (GO:0045576)3.04516286
101positive regulation of mast cell activation (GO:0033005)3.04071885
102definitive hemopoiesis (GO:0060216)3.03290166
103cell killing (GO:0001906)3.02159194
104icosanoid biosynthetic process (GO:0046456)3.01796363
105fatty acid derivative biosynthetic process (GO:1901570)3.01796363
106endothelial cell chemotaxis (GO:0035767)3.01732911
107tryptophan metabolic process (GO:0006568)3.00275397
108reactive oxygen species biosynthetic process (GO:1903409)2.98364326
109mesodermal cell differentiation (GO:0048333)2.98235973
110angiogenesis involved in wound healing (GO:0060055)2.97350329
111positive regulation of gamma-delta T cell activation (GO:0046645)2.96168396
112positive regulation of lymphocyte migration (GO:2000403)2.91141988
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.89942443
114blood coagulation, intrinsic pathway (GO:0007597)2.89811876
115regulation of hypersensitivity (GO:0002883)2.89394128
116response to fungus (GO:0009620)2.88782557
117positive regulation of respiratory burst (GO:0060267)2.87905579
118regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86805173
119positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.86522879
120regulation of phagocytosis (GO:0050764)2.85963185
121positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85557812
122defense response to bacterium (GO:0042742)2.85470248
123piRNA metabolic process (GO:0034587)2.85186853
124myeloid dendritic cell activation (GO:0001773)2.84055132
125megakaryocyte development (GO:0035855)2.83427153
126maturation of SSU-rRNA (GO:0030490)2.83249276
127lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82948157
128histamine secretion (GO:0001821)2.82452668
129bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80824574
130regulation of B cell apoptotic process (GO:0002902)2.78998582
131G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.78295778
132B cell receptor signaling pathway (GO:0050853)2.77677040
133antigen processing and presentation of endogenous antigen (GO:0019883)2.77089496
134leukocyte cell-cell adhesion (GO:0007159)2.76977472
135neutrophil chemotaxis (GO:0030593)2.76636627
136monocyte chemotaxis (GO:0002548)2.75896858
137regulation of lymphocyte migration (GO:2000401)2.73695282
138disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.72464932
139killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.72464932
140negative regulation of interleukin-6 production (GO:0032715)2.72191595
141regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70292712
142positive regulation of T cell chemotaxis (GO:0010820)2.69210849
143regulation of T cell chemotaxis (GO:0010819)2.69210849
144regulation of water loss via skin (GO:0033561)2.68695657
145positive regulation of mast cell activation involved in immune response (GO:0033008)2.68663716
146positive regulation of mast cell degranulation (GO:0043306)2.68663716
147neutrophil migration (GO:1990266)2.68133450
148myeloid leukocyte mediated immunity (GO:0002444)2.67963458
149response to protozoan (GO:0001562)2.67168164
150positive regulation of interleukin-1 beta secretion (GO:0050718)2.66845719
151lactate metabolic process (GO:0006089)2.65772241
152purinergic nucleotide receptor signaling pathway (GO:0035590)2.64576134
153mast cell activation involved in immune response (GO:0002279)2.58216831
154mast cell degranulation (GO:0043303)2.58216831
155negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.57591466
156positive regulation of granulocyte differentiation (GO:0030854)2.57151705
157granulocyte migration (GO:0097530)2.56384015
158Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55348748
159negative regulation of interleukin-17 production (GO:0032700)2.54739739
160negative regulation of interleukin-10 production (GO:0032693)2.54425548
161leukocyte mediated cytotoxicity (GO:0001909)2.53884518
162macrophage activation (GO:0042116)2.53874990
163cytokine metabolic process (GO:0042107)2.53656167
164negative regulation of bone resorption (GO:0045779)2.52563607
165secretory granule organization (GO:0033363)2.52538126
166granulocyte chemotaxis (GO:0071621)2.52328168
167response to bacterium (GO:0009617)2.51787236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.04131870
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.44751896
3SCL_19346495_ChIP-Seq_HPC-7_Human3.49211685
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.40039181
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.35550746
6MYB_21317192_ChIP-Seq_ERMYB_Mouse3.25170317
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23123243
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.05620633
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.96121968
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79768384
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78480524
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.62749987
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55025677
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.50014283
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.35894241
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34484579
17* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.32673591
18IGF1R_20145208_ChIP-Seq_DFB_Human2.31160286
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.22907945
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.19156136
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15513334
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12572597
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10967677
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10177145
25ZNF274_21170338_ChIP-Seq_K562_Hela2.08073851
26GATA3_26560356_Chip-Seq_TH2_Human2.07684927
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06587643
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06304281
29TP63_17297297_ChIP-ChIP_HaCaT_Human10.0407972
30RUNX_20019798_ChIP-Seq_JUKART_Human1.97949245
31* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.93731783
32VDR_22108803_ChIP-Seq_LS180_Human1.79990171
33* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76437389
34P63_26484246_Chip-Seq_KERATINOCYTES_Human1.75026491
35VDR_23849224_ChIP-Seq_CD4+_Human1.74168049
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71625194
37* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67782699
38SPI1_23547873_ChIP-Seq_NB4_Human1.66446175
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62749411
40VDR_24763502_ChIP-Seq_THP-1_Human1.60877667
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57583275
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.54466432
43ER_23166858_ChIP-Seq_MCF-7_Human1.53169458
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52811003
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52624818
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52477185
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52477185
48GATA3_27048872_Chip-Seq_THYMUS_Human1.51227866
49TCF7_22412390_ChIP-Seq_EML_Mouse1.49116980
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49069244
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48699135
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.47986935
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.45708107
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44560775
55SPI1_23127762_ChIP-Seq_K562_Human1.43492739
56MAF_26560356_Chip-Seq_TH1_Human1.42710842
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.40976761
58UTX_26944678_Chip-Seq_JUKART_Human1.40946784
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38598538
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.38455087
61E2F7_22180533_ChIP-Seq_HELA_Human1.38313664
62IRF1_19129219_ChIP-ChIP_H3396_Human1.35860814
63ELK1_19687146_ChIP-ChIP_HELA_Human1.35392091
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34837856
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34440209
66MYB_26560356_Chip-Seq_TH2_Human1.34152269
67GBX2_23144817_ChIP-Seq_PC3_Human1.33858454
68VDR_21846776_ChIP-Seq_THP-1_Human1.33672299
69* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33571856
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33062758
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.32792665
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31883253
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31877799
74ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30916546
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29930148
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.29507505
77PU_27001747_Chip-Seq_BMDM_Mouse1.28968001
78GATA2_19941826_ChIP-Seq_K562_Human1.28072033
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26971306
80GATA1_19941826_ChIP-Seq_K562_Human1.25837413
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24875224
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22238693
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22105037
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21860388
85GATA1_22025678_ChIP-Seq_K562_Human1.21078260
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20633071
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20405282
88GATA2_21666600_ChIP-Seq_HMVEC_Human1.17204743
89EGR1_19032775_ChIP-ChIP_M12_Human1.14860717
90CBP_20019798_ChIP-Seq_JUKART_Human1.14636355
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14636355
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12916809
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11975192
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11426744
95MYC_22102868_ChIP-Seq_BL_Human1.09778432
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.08736461
97FOXP3_21729870_ChIP-Seq_TREG_Human1.08107932
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07671880
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.06153909
100EWS_26573619_Chip-Seq_HEK293_Human1.05933738
101LXR_22292898_ChIP-Seq_THP-1_Human1.05140594
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04847226
103TP53_22573176_ChIP-Seq_HFKS_Human1.04813722
104TP53_16413492_ChIP-PET_HCT116_Human1.04113875
105* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03480118
106TAF15_26573619_Chip-Seq_HEK293_Human1.03200976
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.02665815
108PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02268550
109SMRT_27268052_Chip-Seq_Bcells_Human1.02192034
110* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01302664
111GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01292302
112ESR2_21235772_ChIP-Seq_MCF-7_Human1.00525556
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00490732
114VDR_24787735_ChIP-Seq_THP-1_Human1.00402504
115* NFE2_27457419_Chip-Seq_LIVER_Mouse1.00091570
116BCAT_22108803_ChIP-Seq_LS180_Human0.99745503
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99477868
118FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99319399
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98850473
120* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98637689
121GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97417911
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96924962
123FOXA1_25329375_ChIP-Seq_VCAP_Human0.96924962
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96826896
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96609169
126GATA3_21878914_ChIP-Seq_MCF-7_Human0.95708076
127RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94763435
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94672546
129TRIM28_21343339_ChIP-Seq_HEK293_Human0.94385118
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94328559
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94256534
132* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91264913
133AR_20517297_ChIP-Seq_VCAP_Human0.90841909
134NANOG_19829295_ChIP-Seq_ESCs_Human0.90474881
135SOX2_19829295_ChIP-Seq_ESCs_Human0.90474881
136SALL4_22934838_ChIP-ChIP_CD34+_Human0.89470793
137BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.89215702
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88150052
139CJUN_26792858_Chip-Seq_BT549_Human0.87430350
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85198909
141SOX2_20726797_ChIP-Seq_SW620_Human0.84527696
142SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84369775
143TCF4_18268006_ChIP-ChIP_LS174T_Human0.83658411
144* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83423185
145MYB_26560356_Chip-Seq_TH1_Human0.83088609
146SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81767557
147BCOR_27268052_Chip-Seq_Bcells_Human0.81537309
148CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81289394
149RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80602943
150SPI1_20517297_ChIP-Seq_HL60_Human0.80296634
151TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79955131
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79293956
153RUNX1_27514584_Chip-Seq_MCF-7_Human0.78011519
154PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77623298
155HIF1A_21447827_ChIP-Seq_MCF-7_Human0.76032648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.42339654
2MP0000569_abnormal_digit_pigmentation3.91672164
3MP0003436_decreased_susceptibility_to3.53298606
4MP0000383_abnormal_hair_follicle3.03192218
5MP0004510_myositis2.91741903
6MP0003724_increased_susceptibility_to2.88420563
7MP0005464_abnormal_platelet_physiology2.86755093
8MP0001835_abnormal_antigen_presentation2.83654700
9MP0003453_abnormal_keratinocyte_physiol2.75780363
10MP0004381_abnormal_hair_follicle2.68422993
11MP0002419_abnormal_innate_immunity2.67476445
12MP0004947_skin_inflammation2.56605968
13MP0009785_altered_susceptibility_to2.55515754
14MP0005025_abnormal_response_to2.47689449
15MP0000465_gastrointestinal_hemorrhage2.43225506
16MP0002060_abnormal_skin_morphology2.38773049
17MP0002148_abnormal_hypersensitivity_rea2.32624661
18MP0000685_abnormal_immune_system2.32329618
19MP0005387_immune_system_phenotype2.31254482
20MP0001790_abnormal_immune_system2.31254482
21MP0003172_abnormal_lysosome_physiology2.30994057
22MP0002796_impaired_skin_barrier2.26747611
23MP0005000_abnormal_immune_tolerance2.23496038
24MP0003566_abnormal_cell_adhesion2.23449864
25MP0001851_eye_inflammation2.19944259
26MP0003303_peritoneal_inflammation2.11890483
27MP0000015_abnormal_ear_pigmentation2.06905534
28MP0000566_synostosis2.04826961
29MP0000579_abnormal_nail_morphology2.02408436
30MP0001853_heart_inflammation2.02099517
31MP0010678_abnormal_skin_adnexa2.00757977
32MP0001216_abnormal_epidermal_layer1.99320200
33MP0000467_abnormal_esophagus_morphology1.98471344
34MP0001800_abnormal_humoral_immune1.97174549
35MP0001533_abnormal_skeleton_physiology1.96609185
36MP0002452_abnormal_antigen_presenting1.91021992
37MP0002396_abnormal_hematopoietic_system1.79455557
38MP0008877_abnormal_DNA_methylation1.79234657
39MP0002405_respiratory_system_inflammati1.79169832
40MP0002166_altered_tumor_susceptibility1.76607979
41MP0005409_darkened_coat_color1.76299330
42MP0002420_abnormal_adaptive_immunity1.73371575
43MP0001819_abnormal_immune_cell1.71277174
44MP0005167_abnormal_blood-brain_barrier1.63011914
45MP0005023_abnormal_wound_healing1.63011504
46MP0002723_abnormal_immune_serum1.62712225
47MP0003787_abnormal_imprinting1.61974219
48MP0002006_tumorigenesis1.61653029
49MP0004147_increased_porphyrin_level1.56644101
50MP0001845_abnormal_inflammatory_respons1.53197448
51MP0003075_altered_response_to1.51814817
52MP0001346_abnormal_lacrimal_gland1.50016682
53MP0005075_abnormal_melanosome_morpholog1.49623693
54MP0003828_pulmonary_edema1.49201637
55MP0003941_abnormal_skin_development1.47447207
56MP0010155_abnormal_intestine_physiology1.42097027
57MP0010771_integument_phenotype1.41400904
58MP0009278_abnormal_bone_marrow1.39450480
59MP0003448_altered_tumor_morphology1.39155591
60MP0000371_diluted_coat_color1.35594846
61MP0002098_abnormal_vibrissa_morphology1.34704768
62MP0004742_abnormal_vestibular_system1.34612702
63MP0000343_altered_response_to1.33403495
64MP0002398_abnormal_bone_marrow1.31274702
65MP0005174_abnormal_tail_pigmentation1.29968525
66MP0001191_abnormal_skin_condition1.27300576
67MP0003646_muscle_fatigue1.25576036
68MP0009764_decreased_sensitivity_to1.25326734
69MP0009931_abnormal_skin_appearance1.23887214
70MP0000716_abnormal_immune_system1.20126365
71MP0002837_dystrophic_cardiac_calcinosis1.19880328
72MP0005671_abnormal_response_to1.18729854
73MP0000762_abnormal_tongue_morphology1.17795639
74MP0001986_abnormal_taste_sensitivity1.17794439
75MP0002877_abnormal_melanocyte_morpholog1.17441637
76MP0009046_muscle_twitch1.15927784
77MP0005275_abnormal_skin_tensile1.14340235
78MP0002933_joint_inflammation1.13741754
79MP0005058_abnormal_lysosome_morphology1.13034680
80MP0005501_abnormal_skin_physiology1.12842155
81MP0001545_abnormal_hematopoietic_system1.11606179
82MP0005397_hematopoietic_system_phenotyp1.11606179
83MP0010352_gastrointestinal_tract_polyps1.11149946
84MP0001764_abnormal_homeostasis1.10793747
85MP0002722_abnormal_immune_system1.09239198
86MP0003950_abnormal_plasma_membrane1.08972196
87MP0003763_abnormal_thymus_physiology1.07746300
88MP0005390_skeleton_phenotype1.06815606
89MP0002132_abnormal_respiratory_system1.06279207
90MP0000377_abnormal_hair_follicle1.06251750
91MP0002429_abnormal_blood_cell1.05255343
92MP0000427_abnormal_hair_cycle1.03952873
93MP0010094_abnormal_chromosome_stability1.03455663
94MP0006054_spinal_hemorrhage1.03159452
95MP0001849_ear_inflammation1.02225575
96MP0005645_abnormal_hypothalamus_physiol1.02081932
97MP0010234_abnormal_vibrissa_follicle1.01769284
98MP0000689_abnormal_spleen_morphology1.01363277
99MP0005076_abnormal_cell_differentiation1.00988083
100MP0002095_abnormal_skin_pigmentation0.99230272
101MP0005164_abnormal_response_to0.98743907
102MP0003806_abnormal_nucleotide_metabolis0.98314968
103MP0003705_abnormal_hypodermis_morpholog0.98002233
104MP0003638_abnormal_response/metabolism_0.97837381
105MP0003195_calcinosis0.96997117
106MP0008469_abnormal_protein_level0.95505729
107MP0001501_abnormal_sleep_pattern0.95380330
108MP0005389_reproductive_system_phenotype0.94559004
109MP0000372_irregular_coat_pigmentation0.92076579
110MP0000858_altered_metastatic_potential0.91180389
111MP0006082_CNS_inflammation0.90542755
112MP0009763_increased_sensitivity_to0.89458403
113MP0008875_abnormal_xenobiotic_pharmacok0.89128862
114MP0001873_stomach_inflammation0.84198857
115MP0005360_urolithiasis0.83776367
116MP0003300_gastrointestinal_ulcer0.83621588
117MP0003191_abnormal_cellular_cholesterol0.82928668
118MP0000470_abnormal_stomach_morphology0.81688066
119MP0005310_abnormal_salivary_gland0.81574484
120MP0000367_abnormal_coat/_hair0.80731682
121MP0008058_abnormal_DNA_repair0.79928713
122MP0009333_abnormal_splenocyte_physiolog0.78671461
123MP0008004_abnormal_stomach_pH0.78655312
124MP0000647_abnormal_sebaceous_gland0.78528501
125MP0009840_abnormal_foam_cell0.78259968
126MP0008872_abnormal_physiological_respon0.76512077
127MP0005410_abnormal_fertilization0.76058614
128MP0002009_preneoplasia0.75612319
129MP0001919_abnormal_reproductive_system0.75304544
130MP0006036_abnormal_mitochondrial_physio0.74952287
131MP0002282_abnormal_trachea_morphology0.73530624
132MP0001663_abnormal_digestive_system0.72586632
133MP0005647_abnormal_sex_gland0.72517965
134MP0002735_abnormal_chemical_nociception0.72062715
135MP0002019_abnormal_tumor_incidence0.71714762
136MP0002876_abnormal_thyroid_physiology0.71280803
137MP0004808_abnormal_hematopoietic_stem0.70744168
138MP0002693_abnormal_pancreas_physiology0.70555594
139MP0009765_abnormal_xenobiotic_induced0.70259798
140MP0002075_abnormal_coat/hair_pigmentati0.69470083
141MP0003183_abnormal_peptide_metabolism0.69374958
142MP0008057_abnormal_DNA_replication0.69183843
143MP0005376_homeostasis/metabolism_phenot0.68513709
144MP0005319_abnormal_enzyme/_coenzyme0.68414758
145MP0006035_abnormal_mitochondrial_morpho0.68211885
146MP0002998_abnormal_bone_remodeling0.67452751
147MP0005551_abnormal_eye_electrophysiolog0.66614935
148MP0003656_abnormal_erythrocyte_physiolo0.66334838
149MP0004883_abnormal_blood_vessel0.65153596
150MP0005266_abnormal_metabolism0.64700553
151MP0000703_abnormal_thymus_morphology0.64360887

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)6.67473200
2Milia (HP:0001056)6.12647387
3Purpura (HP:0000979)5.97955009
4Recurrent abscess formation (HP:0002722)5.76411738
5Menorrhagia (HP:0000132)5.37267294
6Thick nail (HP:0001805)5.31168075
7Eczematoid dermatitis (HP:0000976)5.25665360
8Systemic lupus erythematosus (HP:0002725)5.19848555
9Increased mean platelet volume (HP:0011877)5.17522289
10Abnormal platelet volume (HP:0011876)5.11118821
11Prolonged bleeding time (HP:0003010)5.07777827
12Recurrent bacterial skin infections (HP:0005406)5.03052835
13Plantar hyperkeratosis (HP:0007556)4.72318192
14Fragile nails (HP:0001808)4.71237828
15Recurrent gram-negative bacterial infections (HP:0005420)4.42473715
16Gingival bleeding (HP:0000225)4.22337107
17Onycholysis (HP:0001806)4.19442793
18Chronic otitis media (HP:0000389)4.14943673
19Abnormality of macrophages (HP:0004311)3.91658649
20Myositis (HP:0100614)3.81728722
21Ridged nail (HP:0001807)3.67659032
22Orchitis (HP:0100796)3.60908651
23Atrophic scars (HP:0001075)3.42874266
24Palmoplantar hyperkeratosis (HP:0000972)3.36087048
25Retrobulbar optic neuritis (HP:0100654)3.25097693
26Optic neuritis (HP:0100653)3.25097693
27Hypochromic microcytic anemia (HP:0004840)3.24908973
28Granulocytopenia (HP:0001913)3.19455475
29Epistaxis (HP:0000421)3.16888054
30Cellulitis (HP:0100658)3.16804428
31Abnormality of B cell number (HP:0010975)3.14585784
32Palmar hyperkeratosis (HP:0010765)3.12560420
33Recurrent skin infections (HP:0001581)3.10698770
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.10338292
35Eosinophilia (HP:0001880)3.08360287
36Recurrent fungal infections (HP:0002841)3.03415531
37Abnormal blistering of the skin (HP:0008066)3.01800984
38Chronic obstructive pulmonary disease (HP:0006510)3.01068141
39Obstructive lung disease (HP:0006536)3.01068141
40Nail dystrophy (HP:0008404)2.93711857
41Reticulocytopenia (HP:0001896)2.93632467
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.93501764
43Mediastinal lymphadenopathy (HP:0100721)2.91194669
44Keratoconjunctivitis (HP:0001096)2.90508541
45Congenital stationary night blindness (HP:0007642)2.90358315
46Abnormality of the neuromuscular junction (HP:0003398)2.89957472
47Fatigable weakness (HP:0003473)2.89957472
48Pustule (HP:0200039)2.86747309
49Albinism (HP:0001022)2.82525618
50B lymphocytopenia (HP:0010976)2.82352955
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.80332237
52Abnormality of the prostate (HP:0008775)2.80219515
53Vacuolated lymphocytes (HP:0001922)2.80091901
54Gingivitis (HP:0000230)2.72463589
55Skin ulcer (HP:0200042)2.72296154
56Keratoconjunctivitis sicca (HP:0001097)2.69747013
57Periodontitis (HP:0000704)2.66646018
58Alopecia of scalp (HP:0002293)2.62907022
59Increased IgE level (HP:0003212)2.61108942
6011 pairs of ribs (HP:0000878)2.56170695
61Elevated erythrocyte sedimentation rate (HP:0003565)2.51915391
62Interstitial pulmonary disease (HP:0006530)2.50753211
63Recurrent viral infections (HP:0004429)2.50154455
64Abnormality of T cell physiology (HP:0011840)2.47305208
65Vasculitis (HP:0002633)2.45727980
66Abnormality of eosinophils (HP:0001879)2.43833120
67Hypotrichosis (HP:0001006)2.40753321
68Gangrene (HP:0100758)2.40400639
69Panhypogammaglobulinemia (HP:0003139)2.37476066
70Meningitis (HP:0001287)2.37298210
71Osteolytic defects of the hand bones (HP:0009699)2.36099127
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.36099127
73Abnormality of midbrain morphology (HP:0002418)2.35708454
74Molar tooth sign on MRI (HP:0002419)2.35708454
75Hypochromic anemia (HP:0001931)2.34832137
76Autoimmune thrombocytopenia (HP:0001973)2.33902673
77Aplasia cutis congenita (HP:0001057)2.31796081
78Urticaria (HP:0001025)2.31263989
79Sepsis (HP:0100806)2.30301268
80Neutropenia (HP:0001875)2.29603016
81Hemoptysis (HP:0002105)2.28397760
82Increased neuronal autofluorescent lipopigment (HP:0002074)2.28046612
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27502853
84Glomerulonephritis (HP:0000099)2.27181134
85Bruising susceptibility (HP:0000978)2.26807890
86Lip pit (HP:0100267)2.24659806
87Erythema (HP:0010783)2.23869344
88Abnormality of complement system (HP:0005339)2.21748097
89Anomalous pulmonary venous return (HP:0010772)2.21364865
90Amyloidosis (HP:0011034)2.21074499
91Impaired platelet aggregation (HP:0003540)2.20683945
92Abnormal platelet function (HP:0011869)2.20683945
93Acute lymphatic leukemia (HP:0006721)2.19867534
94Duplicated collecting system (HP:0000081)2.19255545
95Abnormal rod and cone electroretinograms (HP:0008323)2.18997175
96Increased cerebral lipofuscin (HP:0011813)2.18127904
97Constricted visual fields (HP:0001133)2.16631885
98IgM deficiency (HP:0002850)2.15978617
99Pili torti (HP:0003777)2.15073157
100Hematochezia (HP:0002573)2.14816350
101Recurrent sinusitis (HP:0011108)2.14630516
102Pancreatic cysts (HP:0001737)2.14405651
103Chest pain (HP:0100749)2.11856305
104Recurrent cutaneous fungal infections (HP:0011370)2.11257156
105Chronic mucocutaneous candidiasis (HP:0002728)2.11257156
106Absent/shortened dynein arms (HP:0200106)2.08505516
107Dynein arm defect of respiratory motile cilia (HP:0012255)2.08505516
108Arterial thrombosis (HP:0004420)2.07172735
109Stomatitis (HP:0010280)2.05557765
110Abnormality of the renal collecting system (HP:0004742)2.05173954
111Limb hypertonia (HP:0002509)2.04576947
112Autoimmune hemolytic anemia (HP:0001890)2.04205849
113Abnormality of pyrimidine metabolism (HP:0004353)2.01076422
114Encephalitis (HP:0002383)1.99620164
115Protruding tongue (HP:0010808)1.99106534
116Abnormality of liposaccharide metabolism (HP:0010968)1.99095542
117Abnormality of glycosphingolipid metabolism (HP:0004343)1.99095542
118Abnormality of glycolipid metabolism (HP:0010969)1.99095542
119Chromsome breakage (HP:0040012)1.98473785
120Abnormality of the renal cortex (HP:0011035)1.97719284
121Widely spaced teeth (HP:0000687)1.94978099
122Peritonitis (HP:0002586)1.94119488
123Osteomyelitis (HP:0002754)1.91686939
124Blepharitis (HP:0000498)1.88540564
125Hypergammaglobulinemia (HP:0010702)1.88388014
126Xerostomia (HP:0000217)1.86215394
127Thrombocytosis (HP:0001894)1.85321659
128White forelock (HP:0002211)1.85215802
129Nephronophthisis (HP:0000090)1.84728142
130Right ventricular cardiomyopathy (HP:0011663)1.84726296
131Abnormality of the pulmonary veins (HP:0011718)1.83231904
132True hermaphroditism (HP:0010459)1.82683605
133Hypoplasia of the fovea (HP:0007750)1.81217329
134Aplasia/Hypoplasia of the fovea (HP:0008060)1.81217329
135Abnormality of cells of the erythroid lineage (HP:0012130)1.80596710
136Ectropion (HP:0000656)1.79427072
137Clubbing of toes (HP:0100760)1.78468845
138Nephritis (HP:0000123)1.78218993
139Leukopenia (HP:0001882)1.78204607
140Loss of speech (HP:0002371)1.77650502
141Attenuation of retinal blood vessels (HP:0007843)1.75295799
142Hypoplasia of dental enamel (HP:0006297)1.74773867
143Abnormality of the common coagulation pathway (HP:0010990)1.74009554
144Restrictive lung disease (HP:0002091)1.73472214
145Chronic diarrhea (HP:0002028)1.72362321
146Woolly hair (HP:0002224)1.72053194
147Microcytic anemia (HP:0001935)1.71653177
148Colitis (HP:0002583)1.71555928
149Paralysis (HP:0003470)1.70544301
150Progressive inability to walk (HP:0002505)1.69814151
151Leukocytosis (HP:0001974)1.69463586
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69083114
153Pancreatic fibrosis (HP:0100732)1.68978886
154Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68850686
155Skin rash (HP:0000988)1.68103960
156Abnormality of the pleura (HP:0002103)1.67969242
157Abnormality of the thoracic spine (HP:0100711)1.67857915
158Pulmonary infiltrates (HP:0002113)1.67406756
159Hyperhidrosis (HP:0000975)1.67266533
160Abnormality of male internal genitalia (HP:0000022)1.66698499
161Inflammation of the large intestine (HP:0002037)1.66478151
162Patchy hypopigmentation of hair (HP:0011365)1.66174207
163Agammaglobulinemia (HP:0004432)1.63799854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.29309735
2MAP4K14.31830261
3MST1R3.93208477
4ACVR1B3.38909761
5IRAK43.36445927
6TYK23.25601954
7FRK3.11417835
8ERN12.92709677
9TXK2.67810555
10MAP3K32.38161155
11TSSK62.30923344
12BTK2.29992723
13PLK41.99841277
14EPHB11.97039168
15TEC1.87851528
16FLT31.86077297
17MAP3K141.82001279
18STK101.80676202
19SYK1.70260105
20TAOK31.69736445
21NUAK11.67466489
22KIT1.65675603
23ZAK1.64507293
24TLK11.61574796
25PKN21.58618054
26EPHA21.58287117
27CLK11.58016701
28PIM21.51125180
29HCK1.44823161
30MATK1.44134835
31MAP4K21.43469869
32PIK3CG1.41403612
33LRRK21.40950483
34TESK21.40113769
35TRPM71.37960749
36TBK11.37324594
37ZAP701.36437286
38VRK11.30369331
39IKBKE1.28968039
40ITK1.26856478
41FES1.26558143
42TGFBR21.23324816
43MAPK131.23211607
44CSK1.18344662
45IKBKB1.18164048
46IRAK31.17881861
47EEF2K1.17206583
48ADRBK21.16702251
49MARK31.12404509
50JAK11.12398359
51MKNK21.11136107
52SCYL21.08905585
53PTK61.08715658
54MAP3K121.08176466
55MKNK11.08139676
56RPS6KA61.06737201
57GRK11.05286800
58MST41.03821154
59JAK31.02460085
60MAP2K61.02448368
61RPS6KC11.01900544
62RPS6KL11.01900544
63FGFR41.01739023
64INSRR1.00444168
65MAP3K60.99915362
66BCKDK0.98915208
67CAMK1D0.98901594
68BMPR20.97434776
69MAPKAPK30.95866862
70TNK20.95427027
71FGR0.95178252
72RIPK10.91516651
73MAP3K50.91246521
74PIM10.90531404
75STK240.90177294
76BMX0.89959633
77LYN0.89618479
78WNK30.86891690
79RPS6KB20.86618121
80RIPK40.83716952
81CSF1R0.83407890
82LCK0.82237528
83MAP2K30.80348655
84STK38L0.79797978
85MAPKAPK50.77700428
86TTN0.77326860
87ERBB30.77060902
88FGFR30.74619588
89JAK20.73241380
90GRK60.69661783
91MAPKAPK20.68702726
92MAP2K20.67148427
93RPS6KA20.66731512
94PTK2B0.65410914
95PRKCD0.62002996
96CAMKK10.61001217
97TAOK20.60652397
98EPHA30.60534860
99RPS6KA50.60293915
100PRKCQ0.60247556
101PLK20.59594116
102BMPR1B0.59404157
103NEK90.58074200
104CAMKK20.57931683
105MAPK40.57526059
106MAP3K10.56110068
107GRK70.55328301
108ABL10.54586567
109MAP3K110.53201176
110EIF2AK20.52625476
111RPS6KA10.52521172
112PDK10.48851250
113STK30.48469159
114CAMK1G0.43297563
115OXSR10.42256158
116MAPK110.40890573
117MAP3K20.40678157
118CDK190.40426381
119CSNK1G30.40188685
120ADRBK10.38274579
121MAP2K40.37237378
122CHUK0.36730570
123SRPK10.35370921
124DYRK1B0.35214169
125PTK20.34363887
126IGF1R0.34012251
127CSNK1A1L0.32827071
128FER0.32348822
129TNIK0.32240187
130CSNK1G20.29371729
131ATR0.29086458
132CDK60.28478262
133TRIB30.27955835
134PDPK10.27233582
135CHEK20.26016362
136EGFR0.25652546
137RPS6KA40.25329099
138MET0.25270744
139PINK10.23769241
140BRD40.23621654
141EIF2AK30.22969000
142DAPK20.22929368
143ABL20.22918993
144IRAK10.22144381
145FYN0.21736273
146HIPK20.21677741

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051506.06404439
2Leishmaniasis_Homo sapiens_hsa051403.38442708
3Hematopoietic cell lineage_Homo sapiens_hsa046402.96374913
4Complement and coagulation cascades_Homo sapiens_hsa046102.94358397
5Pertussis_Homo sapiens_hsa051332.69444051
6Other glycan degradation_Homo sapiens_hsa005112.58795727
7Osteoclast differentiation_Homo sapiens_hsa043802.35501021
8Ribosome_Homo sapiens_hsa030102.24539235
9Platelet activation_Homo sapiens_hsa046112.22630557
10Legionellosis_Homo sapiens_hsa051342.12707244
11Homologous recombination_Homo sapiens_hsa034402.02013271
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97765519
13Toxoplasmosis_Homo sapiens_hsa051451.95227717
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.90194070
15Malaria_Homo sapiens_hsa051441.88266190
16ECM-receptor interaction_Homo sapiens_hsa045121.86186671
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.82845158
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77686553
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77292680
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74209205
21Allograft rejection_Homo sapiens_hsa053301.73933047
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70534268
23Tuberculosis_Homo sapiens_hsa051521.69423032
24Fanconi anemia pathway_Homo sapiens_hsa034601.67154739
25Histidine metabolism_Homo sapiens_hsa003401.56898794
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.56220036
27* Amoebiasis_Homo sapiens_hsa051461.56017324
28Arachidonic acid metabolism_Homo sapiens_hsa005901.52982089
29Protein export_Homo sapiens_hsa030601.50365559
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45605475
31Caffeine metabolism_Homo sapiens_hsa002321.44733347
32Salmonella infection_Homo sapiens_hsa051321.42909222
33Type I diabetes mellitus_Homo sapiens_hsa049401.41835664
34Autoimmune thyroid disease_Homo sapiens_hsa053201.39940353
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38601972
36Sulfur metabolism_Homo sapiens_hsa009201.38555306
37B cell receptor signaling pathway_Homo sapiens_hsa046621.38536325
38Tryptophan metabolism_Homo sapiens_hsa003801.34649327
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28494912
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.27588924
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.23703656
42Phagosome_Homo sapiens_hsa041451.23271819
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23104610
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.21309038
45Antigen processing and presentation_Homo sapiens_hsa046121.17958448
46Selenocompound metabolism_Homo sapiens_hsa004501.16583286
47Measles_Homo sapiens_hsa051621.15517942
48Ether lipid metabolism_Homo sapiens_hsa005651.14628723
49Primary immunodeficiency_Homo sapiens_hsa053401.12211442
50TNF signaling pathway_Homo sapiens_hsa046681.11791071
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.11456462
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11103837
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09346113
54Chemokine signaling pathway_Homo sapiens_hsa040621.08508604
55Lysosome_Homo sapiens_hsa041421.08430923
56Shigellosis_Homo sapiens_hsa051311.08258513
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.07961169
58Small cell lung cancer_Homo sapiens_hsa052221.04407554
59Influenza A_Homo sapiens_hsa051641.03490770
60Herpes simplex infection_Homo sapiens_hsa051681.01938500
61Apoptosis_Homo sapiens_hsa042101.00418647
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00165321
63Non-homologous end-joining_Homo sapiens_hsa034500.99503604
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98601784
65Phenylalanine metabolism_Homo sapiens_hsa003600.97875775
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95945193
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93870977
68Collecting duct acid secretion_Homo sapiens_hsa049660.93646666
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93642213
70Linoleic acid metabolism_Homo sapiens_hsa005910.92043739
71Rheumatoid arthritis_Homo sapiens_hsa053230.91708336
72p53 signaling pathway_Homo sapiens_hsa041150.90522453
73Renin-angiotensin system_Homo sapiens_hsa046140.89697576
74Hepatitis B_Homo sapiens_hsa051610.89537425
75Asthma_Homo sapiens_hsa053100.82443826
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81497099
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.76580395
78Proteoglycans in cancer_Homo sapiens_hsa052050.76118650
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73927207
80Nitrogen metabolism_Homo sapiens_hsa009100.72931323
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69066597
82Viral myocarditis_Homo sapiens_hsa054160.68687561
83African trypanosomiasis_Homo sapiens_hsa051430.68643143
84Acute myeloid leukemia_Homo sapiens_hsa052210.68510204
85Rap1 signaling pathway_Homo sapiens_hsa040150.67858592
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66798533
87Sphingolipid metabolism_Homo sapiens_hsa006000.65595274
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65319661
89Regulation of autophagy_Homo sapiens_hsa041400.64082904
90Phototransduction_Homo sapiens_hsa047440.61839625
91Base excision repair_Homo sapiens_hsa034100.59746078
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59118803
93Peroxisome_Homo sapiens_hsa041460.58646619
94Oxidative phosphorylation_Homo sapiens_hsa001900.58425336
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57948868
96VEGF signaling pathway_Homo sapiens_hsa043700.56150625
97One carbon pool by folate_Homo sapiens_hsa006700.55269833
98Pathways in cancer_Homo sapiens_hsa052000.53602767
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52582238
100Alcoholism_Homo sapiens_hsa050340.50384239
101Propanoate metabolism_Homo sapiens_hsa006400.50356313
102Butanoate metabolism_Homo sapiens_hsa006500.49953055
103Focal adhesion_Homo sapiens_hsa045100.49599078
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48717517
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47654231
106DNA replication_Homo sapiens_hsa030300.46694019
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46615212
108Nucleotide excision repair_Homo sapiens_hsa034200.46285267
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46143716
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45591161
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44505084
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44072360
113Graft-versus-host disease_Homo sapiens_hsa053320.43172081
114Salivary secretion_Homo sapiens_hsa049700.41785607
115Olfactory transduction_Homo sapiens_hsa047400.40948051
116beta-Alanine metabolism_Homo sapiens_hsa004100.40906291
117Proteasome_Homo sapiens_hsa030500.40771984
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40657995
119ABC transporters_Homo sapiens_hsa020100.40312879
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39475302
121RNA polymerase_Homo sapiens_hsa030200.38598379
122Hepatitis C_Homo sapiens_hsa051600.37988143
123Pyrimidine metabolism_Homo sapiens_hsa002400.37760063
124Pancreatic cancer_Homo sapiens_hsa052120.36658760
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35975306
126Basal transcription factors_Homo sapiens_hsa030220.34502738
127MAPK signaling pathway_Homo sapiens_hsa040100.34150679
128MicroRNAs in cancer_Homo sapiens_hsa052060.33616147
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33442295
130HTLV-I infection_Homo sapiens_hsa051660.33274754
131Chronic myeloid leukemia_Homo sapiens_hsa052200.31205083
132Epstein-Barr virus infection_Homo sapiens_hsa051690.30615305
133Notch signaling pathway_Homo sapiens_hsa043300.30415623
134Bladder cancer_Homo sapiens_hsa052190.29034385
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26909923
136T cell receptor signaling pathway_Homo sapiens_hsa046600.26189910
137Vitamin digestion and absorption_Homo sapiens_hsa049770.24403239
138Viral carcinogenesis_Homo sapiens_hsa052030.23618459
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21865629
140Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.21792200
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.21334847
142Systemic lupus erythematosus_Homo sapiens_hsa053220.21258292
143Mismatch repair_Homo sapiens_hsa034300.20259716
144Serotonergic synapse_Homo sapiens_hsa047260.20202742
145Adherens junction_Homo sapiens_hsa045200.20142784
146Ovarian steroidogenesis_Homo sapiens_hsa049130.20002277

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