SERPINB11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.70961287
2primary alcohol catabolic process (GO:0034310)9.68050815
3ethanol metabolic process (GO:0006067)8.73850918
4renal absorption (GO:0070293)8.67350319
5left/right pattern formation (GO:0060972)8.22451027
6negative regulation of epidermal cell differentiation (GO:0045605)8.00724517
7diterpenoid biosynthetic process (GO:0016102)7.96512944
8regulation of cilium movement (GO:0003352)7.29890341
9negative regulation of epidermis development (GO:0045683)6.86225850
10multicellular organismal water homeostasis (GO:0050891)6.78427814
11one-carbon compound transport (GO:0019755)6.44638408
12regulation of keratinocyte proliferation (GO:0010837)6.32302922
13left/right axis specification (GO:0070986)6.16071062
14hemidesmosome assembly (GO:0031581)6.13234699
15regulation of keratinocyte differentiation (GO:0045616)6.10238437
16intraciliary transport (GO:0042073)5.94299704
17microtubule bundle formation (GO:0001578)5.87590972
18antibacterial humoral response (GO:0019731)5.85047476
19terpenoid biosynthetic process (GO:0016114)5.80573551
20cilium organization (GO:0044782)5.80078386
21pyrimidine-containing compound transmembrane transport (GO:0072531)5.79007411
22ventricular system development (GO:0021591)5.70611635
23water homeostasis (GO:0030104)5.66710193
24cilium assembly (GO:0042384)5.63295058
25antimicrobial humoral response (GO:0019730)5.56100889
26desmosome organization (GO:0002934)5.48420515
27establishment of skin barrier (GO:0061436)5.40075871
28L-ascorbic acid metabolic process (GO:0019852)5.33944151
29negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.23992392
30regulation of water loss via skin (GO:0033561)5.20914057
31protein localization to cilium (GO:0061512)5.19329469
32centriole assembly (GO:0098534)5.18488852
33cardiovascular system development (GO:0072358)5.17924330
34bundle of His cell to Purkinje myocyte communication (GO:0086069)4.98688500
35regulation of toll-like receptor 4 signaling pathway (GO:0034143)4.77359454
36activation of MAPKKK activity (GO:0000185)4.76013624
37regulation of microtubule-based movement (GO:0060632)4.68336549
38gas transport (GO:0015669)4.47294746
39cellular component assembly involved in morphogenesis (GO:0010927)4.45696015
40negative regulation of T cell differentiation in thymus (GO:0033085)4.45362385
41lung epithelium development (GO:0060428)4.44888374
42retinoic acid metabolic process (GO:0042573)4.43861734
43retinol metabolic process (GO:0042572)4.38918059
44cilium morphogenesis (GO:0060271)4.35863719
45tolerance induction (GO:0002507)4.35250852
46sperm capacitation (GO:0048240)4.30989286
47exogenous drug catabolic process (GO:0042738)4.23329689
48xenobiotic catabolic process (GO:0042178)4.19806573
49negative regulation of immunoglobulin mediated immune response (GO:0002890)4.19093652
50negative regulation of B cell mediated immunity (GO:0002713)4.19093652
51surfactant homeostasis (GO:0043129)4.17498118
52glutathione derivative biosynthetic process (GO:1901687)4.16612375
53glutathione derivative metabolic process (GO:1901685)4.16612375
54regulation of germinal center formation (GO:0002634)4.16064184
55response to xenobiotic stimulus (GO:0009410)4.13314492
56cell projection assembly (GO:0030031)4.07263578
57detection of bacterium (GO:0016045)3.99960743
58microtubule-based movement (GO:0007018)3.99635410
59detection of other organism (GO:0098543)3.99563714
60regulation of secondary heart field cardioblast proliferation (GO:0003266)3.95568666
61regulation of cardioblast proliferation (GO:0003264)3.95568666
62outer ear morphogenesis (GO:0042473)3.90101588
63positive regulation of wound healing (GO:0090303)3.85285087
64positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.85075970
65glomerular epithelial cell development (GO:0072310)3.82203564
66extracellular negative regulation of signal transduction (GO:1900116)3.78014777
67extracellular regulation of signal transduction (GO:1900115)3.78014777
68keratinization (GO:0031424)3.73963963
69regulation of epidermal cell differentiation (GO:0045604)3.64211553
70establishment of apical/basal cell polarity (GO:0035089)3.62021169
71cytoplasmic microtubule organization (GO:0031122)3.61535499
72nucleoside diphosphate phosphorylation (GO:0006165)3.60587954
73regulation of skeletal muscle contraction (GO:0014819)3.59187869
74chemical homeostasis within a tissue (GO:0048875)3.53728112
75positive regulation of tolerance induction (GO:0002645)3.49054079
76positive regulation of vesicle fusion (GO:0031340)3.46861431
77microtubule depolymerization (GO:0007019)3.46697648
78lymph vessel development (GO:0001945)3.45995063
79negative regulation of keratinocyte proliferation (GO:0010839)3.44669667
80drug catabolic process (GO:0042737)3.44238693
81sulfur amino acid catabolic process (GO:0000098)3.43413402
82peptide cross-linking (GO:0018149)3.39024084
83calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.36255723
84keratinocyte proliferation (GO:0043616)3.35593992
85O-glycan processing (GO:0016266)3.33056645
86vitamin transmembrane transport (GO:0035461)3.32252048
87epithelial cell differentiation involved in prostate gland development (GO:0060742)3.27916163
88regulation of epidermis development (GO:0045682)3.27407384
89negative regulation of complement activation (GO:0045916)3.26399951
90primary alcohol metabolic process (GO:0034308)3.25831683
91negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.24385504
92keratinocyte differentiation (GO:0030216)3.22973920
93microtubule polymerization or depolymerization (GO:0031109)3.22736773
94establishment or maintenance of monopolar cell polarity (GO:0061339)3.19772925
95establishment of monopolar cell polarity (GO:0061162)3.19772925
96establishment of planar polarity (GO:0001736)3.19264152
97establishment of tissue polarity (GO:0007164)3.19264152
98retinal metabolic process (GO:0042574)3.17521042
99regulation of interleukin-5 production (GO:0032674)3.15891539
100aldehyde catabolic process (GO:0046185)3.13219562
101positive regulation of osteoblast proliferation (GO:0033690)3.07902042
102excretion (GO:0007588)3.07898442
103progesterone metabolic process (GO:0042448)3.03959204
104toxin metabolic process (GO:0009404)3.03811198
105iron ion import (GO:0097286)3.03631130
106negative regulation of humoral immune response (GO:0002921)3.02510843
107sperm motility (GO:0030317)3.00735830
108oligosaccharide biosynthetic process (GO:0009312)3.00702807
109intestinal epithelial cell development (GO:0060576)3.00106309
110interferon-gamma secretion (GO:0072643)2.99039079
111cellular copper ion homeostasis (GO:0006878)2.96685648
112regulation of phospholipase A2 activity (GO:0032429)2.95277695
113hydrogen peroxide biosynthetic process (GO:0050665)2.94390438
114positive regulation of respiratory burst (GO:0060267)2.91901744
115positive regulation of coagulation (GO:0050820)2.91651699
116amyloid precursor protein catabolic process (GO:0042987)2.89833515
117acute-phase response (GO:0006953)2.88758607
118centriole replication (GO:0007099)2.86985708
119prostaglandin metabolic process (GO:0006693)2.85291140
120prostanoid metabolic process (GO:0006692)2.85291140
121cornea development in camera-type eye (GO:0061303)2.81272886
122epidermis development (GO:0008544)2.81015576
123endocardial cushion morphogenesis (GO:0003203)2.80805611
124folic acid transport (GO:0015884)2.80579223
125middle ear morphogenesis (GO:0042474)2.78210127
126innate immune response in mucosa (GO:0002227)2.76649777
127protein O-linked glycosylation (GO:0006493)2.76420307
128hormone catabolic process (GO:0042447)2.76118136
129negative regulation of protein activation cascade (GO:2000258)2.75443210
130negative regulation of inclusion body assembly (GO:0090084)2.74236232
131lymphangiogenesis (GO:0001946)2.73712499
132G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.73507752
133positive regulation of smoothened signaling pathway (GO:0045880)2.72795763
134determination of left/right symmetry (GO:0007368)2.71412215
135positive regulation of steroid biosynthetic process (GO:0010893)2.70096871
136plasma membrane repair (GO:0001778)2.69473369
137dorsal/ventral neural tube patterning (GO:0021904)2.69202627
138positive regulation of blood coagulation (GO:0030194)2.68656222
139positive regulation of hemostasis (GO:1900048)2.68656222
140smoothened signaling pathway (GO:0007224)2.67688384
141nonmotile primary cilium assembly (GO:0035058)2.64780494
142reactive oxygen species biosynthetic process (GO:1903409)2.64075700
143phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.63389863
144negative regulation of epithelial cell differentiation (GO:0030857)2.61502568
145rRNA catabolic process (GO:0016075)2.60341684
146regulation of steroid hormone biosynthetic process (GO:0090030)2.59385429
147glutathione biosynthetic process (GO:0006750)2.58121331
148determination of bilateral symmetry (GO:0009855)2.57984460
149phenol-containing compound catabolic process (GO:0019336)2.57732598
150regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.57548626
151lung lobe morphogenesis (GO:0060463)2.57178226
152skin morphogenesis (GO:0043589)2.57001930
153carnitine metabolic process (GO:0009437)2.56770059
154lateral ventricle development (GO:0021670)2.55425000
155phosphatidylcholine biosynthetic process (GO:0006656)2.55410727
156polyol transport (GO:0015791)2.54781676
157regulation of interleukin-8 secretion (GO:2000482)2.54327404
158transepithelial transport (GO:0070633)2.54096362
159hydrogen peroxide catabolic process (GO:0042744)2.53195867
160sodium ion homeostasis (GO:0055078)2.52794590
161regulation of transforming growth factor beta1 production (GO:0032908)2.50792150
162specification of symmetry (GO:0009799)2.50532329
163regulation of tolerance induction (GO:0002643)2.50408253
164acute inflammatory response (GO:0002526)2.50382850
165epidermal cell differentiation (GO:0009913)2.49808293
166beta-amyloid metabolic process (GO:0050435)2.49534832
167regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.48569454
168organelle assembly (GO:0070925)2.47847531
169nitric oxide biosynthetic process (GO:0006809)2.47679829
170regulation of collateral sprouting (GO:0048670)2.46628353
171regulation of microtubule depolymerization (GO:0031114)2.46268600
172regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.44716070
173photoreceptor cell maintenance (GO:0045494)2.44693711
174axonemal dynein complex assembly (GO:0070286)19.7754815
175cilium or flagellum-dependent cell motility (GO:0001539)15.9059411
176cilium movement (GO:0003341)13.9991968
177motile cilium assembly (GO:0044458)13.6569678
178epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.7142141
179epithelial cilium movement (GO:0003351)12.6026884
180ethanol oxidation (GO:0006069)11.8523936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.86323917
2* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.07070580
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.88285099
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.13119239
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.04611841
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.94057243
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.86581678
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.71083612
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.69365860
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.57271493
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.50362988
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.38132792
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37205858
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20511578
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.19927751
16VDR_22108803_ChIP-Seq_LS180_Human2.15729078
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12812827
18SOX2_27498859_Chip-Seq_STOMACH_Mouse2.11237757
19ZNF263_19887448_ChIP-Seq_K562_Human2.01434765
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.95222041
21AHR_22903824_ChIP-Seq_MCF-7_Human1.89820409
22SOX2_20726797_ChIP-Seq_SW620_Human1.89645167
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.85853979
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.77778199
25SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75368093
26SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75368093
27NR3C1_21868756_ChIP-Seq_MCF10A_Human1.72928941
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68395233
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67172648
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64731966
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59419607
32TP53_18474530_ChIP-ChIP_U2OS_Human1.58805091
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54783191
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54783191
35ZNF274_21170338_ChIP-Seq_K562_Hela1.53354344
36STAT1_20625510_ChIP-Seq_HELA_Human1.53332594
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49779524
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.48214314
39P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42961218
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.42528131
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.41557126
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39268547
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38464980
44ETV1_20927104_ChIP-Seq_GIST48_Human1.38116702
45PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36857752
46GATA4_25053715_ChIP-Seq_YYC3_Human1.35139136
47RXR_22108803_ChIP-Seq_LS180_Human1.33278398
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33274948
49SMRT_27268052_Chip-Seq_Bcells_Human1.31088223
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30658846
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28892318
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.27096573
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27035098
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26657596
55PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.26494136
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25784570
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24807665
58PHF8_20622853_ChIP-Seq_HELA_Human1.24802810
59FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24465009
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.24357750
61KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24199444
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22329977
63RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22001810
64KLF5_25053715_ChIP-Seq_YYC3_Human1.21856700
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21794940
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21701293
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.21701293
68* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21002673
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20745708
70SMAD3_21741376_ChIP-Seq_HESCs_Human1.20289978
71SMC4_20622854_ChIP-Seq_HELA_Human1.19776714
72RACK7_27058665_Chip-Seq_MCF-7_Human1.17687996
73FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.17385297
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16900141
75TP63_23658742_ChIP-Seq_EP156T_Human1.16871916
76HNFA_21074721_ChIP-Seq_CACO-2_Human1.16162732
77RBPJ_21746931_ChIP-Seq_IB4_Human1.15982331
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15804659
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15361177
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14923724
81GATA6_25053715_ChIP-Seq_YYC3_Human1.13819067
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.13502667
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.12167772
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11635231
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11153272
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10804709
87AR_20517297_ChIP-Seq_VCAP_Human1.10337168
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09402220
89CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09335065
90CEBPB_22108803_ChIP-Seq_LS180_Human1.09260062
91AR_21572438_ChIP-Seq_LNCaP_Human1.08978952
92ER_23166858_ChIP-Seq_MCF-7_Human1.07614336
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06596077
94GATA6_21074721_ChIP-Seq_CACO-2_Human1.06339087
95NFYA_21822215_ChIP-Seq_K562_Human1.05891154
96CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04845255
97TCF4_22108803_ChIP-Seq_LS180_Human1.04274826
98SMAD4_21799915_ChIP-Seq_A2780_Human1.03169760
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03110232
100BCAT_22108803_ChIP-Seq_LS180_Human1.03012263
101NCOR_22424771_ChIP-Seq_293T_Human1.02713301
102IRF8_22096565_ChIP-ChIP_GC-B_Human1.01849064
103RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01382108
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.01050924
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00979666
106GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00929867
107PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00892927
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00762825
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.00295369
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99883031
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.98759662
112STAT3_23295773_ChIP-Seq_U87_Human0.97689323
113EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97392111
114ERG_21242973_ChIP-ChIP_JURKAT_Human0.96878235
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96219455
116EED_16625203_ChIP-ChIP_MESCs_Mouse0.95800933
117CJUN_26792858_Chip-Seq_BT549_Human0.94537792
118TBL1_22424771_ChIP-Seq_293T_Human0.94337155
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94323364
120NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93328167
121NFYB_21822215_ChIP-Seq_K562_Human0.93128267
122CTCF_20526341_ChIP-Seq_ESCs_Human0.92585746
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92406563
124GATA3_24758297_ChIP-Seq_MCF-7_Human0.92196747
125MYC_19829295_ChIP-Seq_ESCs_Human0.91553829
126OCT4_20526341_ChIP-Seq_ESCs_Human0.90954018
127HOXB7_26014856_ChIP-Seq_BT474_Human0.90823448
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90647519
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90262879
130FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90133236
131SMAD_19615063_ChIP-ChIP_OVARY_Human0.90090009
132CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90038797
133CLOCK_20551151_ChIP-Seq_293T_Human0.89557319
134CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89374635
135FOXA2_19822575_ChIP-Seq_HepG2_Human0.89195274
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89153818
137THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88902262
138P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88197168
139RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88188596
140EZH2_27294783_Chip-Seq_ESCs_Mouse0.87834370
141CTCF_27219007_Chip-Seq_Bcells_Human0.84382380
142* FOXA1_25552417_ChIP-Seq_VCAP_Human0.83864794
143NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82292057
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.81637342
145SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81293280
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80742205
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.80539763
148TP53_16413492_ChIP-PET_HCT116_Human0.78930003
149JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77028590
150DROSHA_22980978_ChIP-Seq_HELA_Human0.76918803
151UBF1/2_26484160_Chip-Seq_HMECs_Human0.76473223
152KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.75909269
153KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.75909269
154KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.75909269
155SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.75180164
156TBX20_22080862_ChIP-Seq_HEART_Mouse0.74454192
157TBX20_22328084_ChIP-Seq_HEART_Mouse0.74454192
158TP53_20018659_ChIP-ChIP_R1E_Mouse0.74320583
159EZH2_18974828_ChIP-Seq_MESCs_Mouse0.74266432
160RNF2_18974828_ChIP-Seq_MESCs_Mouse0.74266432
161JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74047539
162* TP63_22573176_ChIP-Seq_HFKS_Human0.73288761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.52762543
2MP0010234_abnormal_vibrissa_follicle4.52510152
3MP0008875_abnormal_xenobiotic_pharmacok4.14677078
4MP0002796_impaired_skin_barrier3.89007535
5MP0001346_abnormal_lacrimal_gland3.69336002
6MP0009780_abnormal_chondrocyte_physiolo3.63391060
7MP0001984_abnormal_olfaction3.57338969
8MP0008789_abnormal_olfactory_epithelium3.56630452
9MP0010368_abnormal_lymphatic_system3.41471917
10MP0010030_abnormal_orbit_morphology3.28861075
11MP0004133_heterotaxia3.19295172
12MP0004043_abnormal_pH_regulation3.08584516
13MP0002098_abnormal_vibrissa_morphology2.99152077
14MP0003941_abnormal_skin_development2.82879717
15MP0002254_reproductive_system_inflammat2.66930812
16MP0005394_taste/olfaction_phenotype2.49017328
17MP0005499_abnormal_olfactory_system2.49017328
18MP0000579_abnormal_nail_morphology2.47129086
19MP0003566_abnormal_cell_adhesion2.33964018
20MP0000537_abnormal_urethra_morphology2.32994235
21MP0005248_abnormal_Harderian_gland2.26857721
22MP0000762_abnormal_tongue_morphology2.24411489
23MP0002060_abnormal_skin_morphology2.22802150
24MP0000467_abnormal_esophagus_morphology2.17777255
25MP0005501_abnormal_skin_physiology2.16995719
26MP0004019_abnormal_vitamin_homeostasis2.14937662
27MP0002876_abnormal_thyroid_physiology2.10308282
28MP0005275_abnormal_skin_tensile2.08981906
29MP0006054_spinal_hemorrhage2.03072322
30MP0003705_abnormal_hypodermis_morpholog2.02625866
31MP0005377_hearing/vestibular/ear_phenot1.99623642
32MP0003878_abnormal_ear_physiology1.99623642
33MP0010678_abnormal_skin_adnexa1.98868491
34MP0001216_abnormal_epidermal_layer1.98439869
35MP0001765_abnormal_ion_homeostasis1.95181363
36MP0004264_abnormal_extraembryonic_tissu1.94075752
37MP0002160_abnormal_reproductive_system1.93267895
38MP0003656_abnormal_erythrocyte_physiolo1.92557338
39MP0002877_abnormal_melanocyte_morpholog1.89774194
40MP0002735_abnormal_chemical_nociception1.78070932
41MP0004947_skin_inflammation1.76582424
42MP0003453_abnormal_keratinocyte_physiol1.75380321
43MP0002909_abnormal_adrenal_gland1.72943127
44MP0002168_other_aberrant_phenotype1.70725516
45MP0000377_abnormal_hair_follicle1.66173408
46MP0003329_amyloid_beta_deposits1.66114308
47MP0003186_abnormal_redox_activity1.65917128
48MP0001849_ear_inflammation1.63323346
49MP0010771_integument_phenotype1.60035691
50MP0000678_abnormal_parathyroid_gland1.58341960
51MP0000465_gastrointestinal_hemorrhage1.56138081
52MP0005636_abnormal_mineral_homeostasis1.55779373
53MP0003183_abnormal_peptide_metabolism1.54094769
54MP0005408_hypopigmentation1.53609739
55MP0000383_abnormal_hair_follicle1.53165961
56MP0002234_abnormal_pharynx_morphology1.51536522
57MP0002277_abnormal_respiratory_mucosa1.47691845
58MP0002132_abnormal_respiratory_system1.46872044
59MP0002139_abnormal_hepatobiliary_system1.46472691
60MP0002233_abnormal_nose_morphology1.46129087
61MP0000647_abnormal_sebaceous_gland1.42947063
62MP0000427_abnormal_hair_cycle1.38914699
63MP0005451_abnormal_body_composition1.37575432
64MP0000613_abnormal_salivary_gland1.34985809
65MP0001485_abnormal_pinna_reflex1.31459663
66MP0009053_abnormal_anal_canal1.29163651
67MP0008872_abnormal_physiological_respon1.27446234
68MP0004272_abnormal_basement_membrane1.27304380
69MP0005395_other_phenotype1.25084790
70MP0002638_abnormal_pupillary_reflex1.24663577
71MP0002249_abnormal_larynx_morphology1.23725283
72MP0001879_abnormal_lymphatic_vessel1.23323273
73MP0005551_abnormal_eye_electrophysiolog1.21383461
74MP0000049_abnormal_middle_ear1.20070955
75MP0004147_increased_porphyrin_level1.16807083
76MP0005220_abnormal_exocrine_pancreas1.09782392
77MP0001191_abnormal_skin_condition1.08024333
78MP0004885_abnormal_endolymph1.07147768
79MP0005253_abnormal_eye_physiology1.06118115
80MP0010352_gastrointestinal_tract_polyps1.05913599
81MP0002136_abnormal_kidney_physiology1.04386306
82MP0005083_abnormal_biliary_tract1.04076245
83MP0000566_synostosis1.04073217
84MP0005389_reproductive_system_phenotype1.03917889
85MP0004381_abnormal_hair_follicle1.02805535
86MP0001664_abnormal_digestion1.02496718
87MP0001851_eye_inflammation1.02068742
88MP0000681_abnormal_thyroid_gland0.95981592
89MP0009643_abnormal_urine_homeostasis0.94698191
90MP0009931_abnormal_skin_appearance0.94365448
91MP0005645_abnormal_hypothalamus_physiol0.94187884
92MP0000604_amyloidosis0.93216228
93MP0003950_abnormal_plasma_membrane0.92914174
94MP0003136_yellow_coat_color0.92619297
95MP0003806_abnormal_nucleotide_metabolis0.92254395
96MP0003195_calcinosis0.91506562
97MP0001340_abnormal_eyelid_morphology0.91232298
98MP0001270_distended_abdomen0.88693623
99MP0005365_abnormal_bile_salt0.88343105
100MP0002734_abnormal_mechanical_nocicepti0.88080552
101MP0004185_abnormal_adipocyte_glucose0.81801147
102MP0004782_abnormal_surfactant_physiolog0.80087038
103MP0000516_abnormal_urinary_system0.79895800
104MP0005367_renal/urinary_system_phenotyp0.79895800
105MP0002177_abnormal_outer_ear0.79569515
106MP0009046_muscle_twitch0.77523183
107MP0001663_abnormal_digestive_system0.77129921
108MP0005646_abnormal_pituitary_gland0.76554756
109MP0001502_abnormal_circadian_rhythm0.76091566
110MP0001915_intracranial_hemorrhage0.75074107
111MP0002282_abnormal_trachea_morphology0.74941071
112MP0005388_respiratory_system_phenotype0.74861303
113MP0002133_abnormal_respiratory_system0.74861303
114MP0001929_abnormal_gametogenesis0.74655680
115MP0004858_abnormal_nervous_system0.74377054
116MP0009764_decreased_sensitivity_to0.74335677
117MP0003718_maternal_effect0.73329689
118MP0003937_abnormal_limbs/digits/tail_de0.72529438
119MP0001970_abnormal_pain_threshold0.72386157
120MP0001756_abnormal_urination0.72308998
121MP0003698_abnormal_male_reproductive0.71461234
122MP0003828_pulmonary_edema0.70692758
123MP0005310_abnormal_salivary_gland0.70175660
124MP0000631_abnormal_neuroendocrine_gland0.67206535
125MP0001243_abnormal_dermal_layer0.67073672
126MP0000627_abnormal_mammary_gland0.65809646
127MP0005195_abnormal_posterior_eye0.65070754
128MP0000367_abnormal_coat/_hair0.65000660
129MP0005023_abnormal_wound_healing0.64905369
130MP0003724_increased_susceptibility_to0.63807289
131MP0006036_abnormal_mitochondrial_physio0.63276324
132MP0010155_abnormal_intestine_physiology0.63042652
133MP0003866_abnormal_defecation0.62892646
134MP0005167_abnormal_blood-brain_barrier0.62579674
135MP0009379_abnormal_foot_pigmentation0.61816393
136MP0002822_catalepsy0.61250102
137MP0009765_abnormal_xenobiotic_induced0.61048761
138MP0005164_abnormal_response_to0.60578515
139MP0002295_abnormal_pulmonary_circulatio0.59520145
140MP0005503_abnormal_tendon_morphology0.59030915
141MP0004883_abnormal_blood_vessel0.58954330
142MP0003632_abnormal_nervous_system0.58428245
143MP0000026_abnormal_inner_ear0.58204888
144MP0000470_abnormal_stomach_morphology0.58146097
145MP0005085_abnormal_gallbladder_physiolo0.57519743
146MP0003075_altered_response_to0.56171896
147MP0002229_neurodegeneration0.55456277
148MP0001177_atelectasis0.54726775
149MP0005623_abnormal_meninges_morphology0.53592384
150MP0003890_abnormal_embryonic-extraembry0.53371762
151MP0001944_abnormal_pancreas_morphology0.52943737
152MP0005165_increased_susceptibility_to0.52632426
153MP0001324_abnormal_eye_pigmentation0.51994700
154MP0001299_abnormal_eye_distance/0.51087835
155MP0002896_abnormal_bone_mineralization0.50803068
156MP0001963_abnormal_hearing_physiology0.50765727
157MP0002135_abnormal_kidney_morphology0.50080680
158MP0003943_abnormal_hepatobiliary_system0.47626337
159MP0005391_vision/eye_phenotype0.46506938

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.79575866
2Hyperactive renin-angiotensin system (HP:0000841)8.77505202
3Bronchiectasis (HP:0002110)7.19630450
4Nasal polyposis (HP:0100582)6.32839559
5Increased circulating renin level (HP:0000848)6.11090479
6Onycholysis (HP:0001806)5.84805176
7Hypokalemic alkalosis (HP:0001949)5.61640357
8Renal salt wasting (HP:0000127)5.43011492
9Right ventricular cardiomyopathy (HP:0011663)5.39260067
10Tetany (HP:0001281)5.38885460
11Abnormality of the nasal mucosa (HP:0000433)5.19637916
12Fragile nails (HP:0001808)5.16828758
13Large eyes (HP:0001090)4.95574292
14Hyperaldosteronism (HP:0000859)4.82083290
15Abnormality of chloride homeostasis (HP:0011422)4.72171896
16Metabolic alkalosis (HP:0200114)4.62987468
17Recurrent sinusitis (HP:0011108)4.25584617
18Bronchitis (HP:0012387)4.20736758
19Milia (HP:0001056)4.19826905
20Abnormality of renin-angiotensin system (HP:0000847)4.14144803
21Lip pit (HP:0100267)4.12309876
22Hypomagnesemia (HP:0002917)4.09154401
23Chronic sinusitis (HP:0011109)4.06527369
24Plantar hyperkeratosis (HP:0007556)4.00921409
25Infertility (HP:0000789)3.98109823
26Polydipsia (HP:0001959)3.69205274
27Abnormal drinking behavior (HP:0030082)3.69205274
28Woolly hair (HP:0002224)3.61443938
29Pancreatic fibrosis (HP:0100732)3.61253299
30Recurrent otitis media (HP:0000403)3.59470128
31Male infertility (HP:0003251)3.49728509
32True hermaphroditism (HP:0010459)3.45904219
33Humeroradial synostosis (HP:0003041)3.43464305
34Synostosis involving the elbow (HP:0003938)3.43464305
35Occipital encephalocele (HP:0002085)3.37534469
36Abnormal platelet function (HP:0011869)3.31614552
37Impaired platelet aggregation (HP:0003540)3.31614552
38Bronchomalacia (HP:0002780)3.21933819
39Abnormality of midbrain morphology (HP:0002418)3.20253800
40Molar tooth sign on MRI (HP:0002419)3.20253800
41Atrophic scars (HP:0001075)3.17995755
42Abnormal blistering of the skin (HP:0008066)3.11293801
43Abnormality of magnesium homeostasis (HP:0004921)3.09626460
44Nephronophthisis (HP:0000090)3.07632470
45Pancreatic cysts (HP:0001737)3.07529745
46Abnormality of fatty-acid metabolism (HP:0004359)2.92229745
47Cystic liver disease (HP:0006706)2.92003200
48Chronic otitis media (HP:0000389)2.91211385
49Pili torti (HP:0003777)2.86738658
50Dehydration (HP:0001944)2.78497373
51Atelectasis (HP:0100750)2.76585994
52Tubulointerstitial nephritis (HP:0001970)2.73598431
53Alkalosis (HP:0001948)2.71913875
54Abnormality of renal excretion (HP:0011036)2.60885378
55Labial hypoplasia (HP:0000066)2.58713786
56Hypercalciuria (HP:0002150)2.58417186
57Abnormality of the renal medulla (HP:0100957)2.58210796
58Distal lower limb muscle weakness (HP:0009053)2.57271676
59Hypotrichosis (HP:0001006)2.57173482
60Down-sloping shoulders (HP:0200021)2.50485210
61Abnormal hemoglobin (HP:0011902)2.49043757
62Fragile skin (HP:0001030)2.47710015
63Chronic hepatic failure (HP:0100626)2.47219400
64Hypokalemia (HP:0002900)2.44556053
65Hypoplasia of dental enamel (HP:0006297)2.43307045
66Postaxial foot polydactyly (HP:0001830)2.41435126
67Chondrocalcinosis (HP:0000934)2.41419393
68Bifid scrotum (HP:0000048)2.40630126
69Nail dystrophy (HP:0008404)2.39796375
70Parakeratosis (HP:0001036)2.39386848
71Congenital ichthyosiform erythroderma (HP:0007431)2.37591644
72Chronic bronchitis (HP:0004469)2.35968358
73Esophageal atresia (HP:0002032)2.33928861
74Adrenal overactivity (HP:0002717)2.28264482
75Abnormality of the distal phalanges of the toes (HP:0010182)2.26828896
76Palmoplantar hyperkeratosis (HP:0000972)2.26463525
77Esophageal varix (HP:0002040)2.26133096
78Hypoplastic female external genitalia (HP:0012815)2.26087016
79Hypotension (HP:0002615)2.25589091
80Abnormality of Sharpey fibers (HP:0100685)2.25144633
81Medial flaring of the eyebrow (HP:0010747)2.24804094
82Congenital malformation of the right heart (HP:0011723)2.23400412
83Double outlet right ventricle (HP:0001719)2.23400412
84Polyuria (HP:0000103)2.20318437
85Hyperkalemia (HP:0002153)2.18497116
86Erythema (HP:0010783)2.15555574
87Alopecia of scalp (HP:0002293)2.14893961
88Stenosis of the external auditory canal (HP:0000402)2.13296956
89Congenital hepatic fibrosis (HP:0002612)2.09071119
90Palmar hyperkeratosis (HP:0010765)2.08840541
91Ulnar bowing (HP:0003031)2.07140889
92Syncope (HP:0001279)2.06218575
93Tubular atrophy (HP:0000092)2.04850544
94Abnormality of the labia (HP:0000058)2.04258170
95Natal tooth (HP:0000695)2.04026683
96Short nail (HP:0001799)2.03536235
97Congenital primary aphakia (HP:0007707)2.02014518
98Increased IgE level (HP:0003212)2.01992921
99Aplasia/Hypoplasia of the tongue (HP:0010295)2.00361225
100Abnormal urine output (HP:0012590)2.00235194
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.9184039
102Abnormal respiratory epithelium morphology (HP:0012253)10.9069943
103Abnormal respiratory motile cilium morphology (HP:0005938)10.9069943
104Dynein arm defect of respiratory motile cilia (HP:0012255)10.8827717
105Absent/shortened dynein arms (HP:0200106)10.8827717
106Abnormal respiratory motile cilium physiology (HP:0012261)10.4971525
107Abnormal ciliary motility (HP:0012262)10.2725562
108Gait imbalance (HP:0002141)1.98730674
109Congenital, generalized hypertrichosis (HP:0004540)1.98260552
110Aplasia/Hypoplasia of the spleen (HP:0010451)1.96769469
111Gout (HP:0001997)1.95822371
112Abnormality of nail color (HP:0100643)1.95671034
113Male pseudohermaphroditism (HP:0000037)1.94794557
114Amyloidosis (HP:0011034)1.93088480
115Acanthosis nigricans (HP:0000956)1.92098227
116Anencephaly (HP:0002323)1.91522201
117Asplenia (HP:0001746)1.90414301
118Abnormality of potassium homeostasis (HP:0011042)1.89853632
119Sparse scalp hair (HP:0002209)1.88609420
120Osteomalacia (HP:0002749)1.88026840
121Bell-shaped thorax (HP:0001591)1.86698124
122Ventricular tachycardia (HP:0004756)1.86534404
123Personality changes (HP:0000751)1.86138259
124Thick nail (HP:0001805)1.84759490
125Cupped ear (HP:0000378)1.84468053
126Neurofibrillary tangles (HP:0002185)1.83226276
127Vascular calcification (HP:0004934)1.81947409
128Furrowed tongue (HP:0000221)1.81604593
129Advanced eruption of teeth (HP:0006288)1.81437802
130Popliteal pterygium (HP:0009756)1.81333419
131Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.78973268
132Nephrogenic diabetes insipidus (HP:0009806)1.76212107
133Pterygium (HP:0001059)1.75969166
134Bowed forearm bones (HP:0003956)1.75124128
135Bowing of the arm (HP:0006488)1.75124128
136Autoimmune hemolytic anemia (HP:0001890)1.73287780
137Oculomotor apraxia (HP:0000657)1.73042829
138Pruritus (HP:0000989)1.72314399
139Broad face (HP:0000283)1.72233213
140Sclerocornea (HP:0000647)1.71954992
141Abnormal hair laboratory examination (HP:0003328)1.71898349
142Recurrent bronchitis (HP:0002837)1.71194447
143Laryngomalacia (HP:0001601)1.70701421
144Nephropathy (HP:0000112)1.70667205
145Palmoplantar keratoderma (HP:0000982)1.68492468
146Decreased circulating renin level (HP:0003351)1.68138670
147Mixed hearing impairment (HP:0000410)1.63266601
148Cardiovascular calcification (HP:0011915)1.63135592
149Abnormality of the gastric mucosa (HP:0004295)1.62814928
150Postaxial hand polydactyly (HP:0001162)1.60836547
151Tubulointerstitial abnormality (HP:0001969)1.56318377
152Decreased central vision (HP:0007663)1.51293212
153Absent rod-and cone-mediated responses on ERG (HP:0007688)1.47073806
154Abnormality of the renal cortex (HP:0011035)1.44736018
155Median cleft lip (HP:0000161)1.43284121
156Absent frontal sinuses (HP:0002688)1.40274350
157Hyponatremia (HP:0002902)1.39868111
158Genital tract atresia (HP:0001827)1.39428940
159Cone-rod dystrophy (HP:0000548)1.39129805
160Vaginal atresia (HP:0000148)1.37719470
161Poor coordination (HP:0002370)1.35189153
162Stage 5 chronic kidney disease (HP:0003774)1.32678423
163Abnormality of macular pigmentation (HP:0008002)1.32333341
164Short thorax (HP:0010306)1.31996870
165Preaxial hand polydactyly (HP:0001177)1.26945819
166Abnormality of the dental root (HP:0006486)1.23248217
167Taurodontia (HP:0000679)1.23248217
168Abnormality of permanent molar morphology (HP:0011071)1.23248217
169Tubulointerstitial fibrosis (HP:0005576)1.21716621
170Abnormal rod and cone electroretinograms (HP:0008323)1.21316986
171Abnormality of the dental pulp (HP:0006479)1.17642668
172Absent speech (HP:0001344)1.14585025
173Aplasia of the musculature (HP:0100854)1.13997144
174Abnormality of molar morphology (HP:0011070)1.13384981
175Abnormality of molar (HP:0011077)1.13384981
176Fetal akinesia sequence (HP:0001989)1.09098814
177Carpal bone hypoplasia (HP:0001498)1.08209014
178Retinitis pigmentosa (HP:0000510)1.07583619
179Hand muscle atrophy (HP:0009130)1.07316975
180Short femoral neck (HP:0100864)1.06584289
181Abnormality of sodium homeostasis (HP:0010931)1.04212102
182Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.04140485
183Abnormality of monocarboxylic acid metabolism (HP:0010996)1.03530872
184Disproportionate short-trunk short stature (HP:0003521)1.03224714
185Spinal muscular atrophy (HP:0007269)1.02546792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.18515653
2EPHB25.03601391
3MST1R4.28697425
4ERBB33.98379712
5EPHA23.04864035
6SGK22.93386178
7TRPM72.85523784
8MAP3K22.76892239
9ERN12.70987272
10PRKD32.51985251
11SGK4942.51725765
12SGK2232.51725765
13SGK32.26865459
14DAPK22.05898847
15LATS12.03791356
16RPS6KB21.98295456
17FER1.80890037
18PTK2B1.77049797
19TLK11.76586401
20NME11.66759698
21LRRK21.61465533
22ACVR1B1.58523145
23PDK21.53193028
24ADRBK21.42442433
25MAP3K31.39555439
26STK101.38341894
27CSK1.34648743
28STK38L1.34367665
29TTK1.29938217
30MAPK151.21732157
31PNCK1.21152689
32CAMKK11.19200789
33STK391.19110429
34MAP2K21.14304671
35BMPR1B1.10321785
36MET1.08189493
37EEF2K1.05601320
38EPHA31.02454533
39WNK41.02033991
40NEK61.00159108
41LATS20.93685866
42SMG10.92203872
43STK380.89224170
44EPHB10.88525252
45HIPK20.86332386
46BRSK20.86265576
47FGFR10.85956537
48PTK60.84370514
49CAMKK20.81994636
50OXSR10.81591131
51CDK60.81151847
52MAP2K10.81019323
53PTK20.79538500
54BCR0.78788295
55MARK20.78670332
56PDGFRB0.76876568
57ADRBK10.74299796
58TBK10.74115212
59MAP3K40.73975343
60MAPKAPK30.73585578
61ERBB20.73436054
62TGFBR10.73082067
63INSRR0.69149701
64PRKD10.68057900
65MAP4K20.67711496
66SGK10.67127174
67GRK60.64776782
68MAP3K70.59592642
69PRKCQ0.59369733
70MAP2K60.58666316
71PRKAA20.58115602
72PBK0.56938288
73CDK190.56266039
74NLK0.55003970
75PRKCE0.54009798
76ROCK20.52394282
77TTN0.50318919
78FGFR40.49931241
79PRKCD0.47654094
80PRKD20.46397040
81PINK10.45098553
82PKN20.43436955
83IKBKE0.41714260
84IGF1R0.41671289
85SRC0.41543218
86FGFR20.40818665
87MAPK130.40001406
88TESK10.39932974
89EGFR0.39861871
90TAOK10.38994265
91BMX0.38372435
92PAK30.38089018
93TYRO30.37533849
94EPHA40.37499849
95FRK0.36703697
96PRKCI0.36511921
97PRKACA0.36460494
98PHKG10.35656203
99PHKG20.35656203
100MAP3K120.35288785
101MAP2K70.35020820
102FGFR30.34667445
103PRKCH0.34638896
104TGFBR20.34496096
105CAMK2G0.33441597
106BTK0.33165337
107FYN0.32932997
108CAMK2A0.32874384
109ZAK0.32573717
110CSNK1G20.32477987
111KIT0.32463755
112CDC42BPA0.32440331
113ABL10.31302878
114PRKCA0.31093548
115RIPK10.30216681
116WNK30.30188313
117ZAP700.29999801
118ERBB40.29456959
119CHUK0.29230484
120STK30.28974096
121ITK0.27569268
122STK40.27091915
123STK240.27052516
124PRKCZ0.25817097
125CSNK1A1L0.25218275
126CDK80.24734415
127JAK20.24715403
128STK160.24592377
129MATK0.24247076
130GRK10.24000386
131KSR10.22907300
132MAPKAPK50.22371903
133PDPK10.22097868
134DYRK1A0.21502406
135MAP3K90.21292318
136PRKG20.21040223
137MAP3K10.20981516
138AURKA0.18613048
139MELK0.16702314
140ROCK10.16412994
141MAP3K130.16013385
142ABL20.15808781
143MYLK0.14281506
144MAPK70.14199547
145PRKAA10.14122559
146STK110.14024710

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009826.13091668
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.75639695
3Chemical carcinogenesis_Homo sapiens_hsa052044.91851516
4Sulfur metabolism_Homo sapiens_hsa009203.97535875
5Tyrosine metabolism_Homo sapiens_hsa003503.27797229
6Retinol metabolism_Homo sapiens_hsa008303.05464619
7Glutathione metabolism_Homo sapiens_hsa004802.79681221
8Fatty acid degradation_Homo sapiens_hsa000712.24805868
9Linoleic acid metabolism_Homo sapiens_hsa005912.23116419
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20579001
11Phenylalanine metabolism_Homo sapiens_hsa003602.16682035
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.11325314
13Sulfur relay system_Homo sapiens_hsa041222.06019418
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.02619312
15Histidine metabolism_Homo sapiens_hsa003401.96609154
16Gastric acid secretion_Homo sapiens_hsa049711.91386577
17Huntingtons disease_Homo sapiens_hsa050161.88769169
18Other glycan degradation_Homo sapiens_hsa005111.49835166
19beta-Alanine metabolism_Homo sapiens_hsa004101.28502308
20Salivary secretion_Homo sapiens_hsa049701.12734407
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.09203796
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09052138
23Adherens junction_Homo sapiens_hsa045201.07815653
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07153370
25Tight junction_Homo sapiens_hsa045301.07006562
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06274371
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05519766
28Leishmaniasis_Homo sapiens_hsa051401.04512572
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03997364
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01715333
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97478906
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97092764
33Caffeine metabolism_Homo sapiens_hsa002320.94969127
34ECM-receptor interaction_Homo sapiens_hsa045120.94376566
35Taste transduction_Homo sapiens_hsa047420.93287307
36Leukocyte transendothelial migration_Homo sapiens_hsa046700.92036663
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90290260
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.88810507
39Arachidonic acid metabolism_Homo sapiens_hsa005900.85854615
40Nitrogen metabolism_Homo sapiens_hsa009100.85451771
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84646064
42Butanoate metabolism_Homo sapiens_hsa006500.82509607
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75134017
44Selenocompound metabolism_Homo sapiens_hsa004500.75007914
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73755475
46Complement and coagulation cascades_Homo sapiens_hsa046100.70043752
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.66648179
48Hippo signaling pathway_Homo sapiens_hsa043900.66607359
49Toxoplasmosis_Homo sapiens_hsa051450.66296587
50Tryptophan metabolism_Homo sapiens_hsa003800.64028369
51Bladder cancer_Homo sapiens_hsa052190.63408111
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.63220116
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62184426
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.61683381
55Pertussis_Homo sapiens_hsa051330.61675654
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60381824
57Arginine and proline metabolism_Homo sapiens_hsa003300.58602097
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.57584434
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57199201
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57086495
61Asthma_Homo sapiens_hsa053100.54382751
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54100803
63Axon guidance_Homo sapiens_hsa043600.53288465
64Hepatitis C_Homo sapiens_hsa051600.51900705
65Type I diabetes mellitus_Homo sapiens_hsa049400.51806457
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51173672
67Thyroid hormone synthesis_Homo sapiens_hsa049180.49355299
68Basal cell carcinoma_Homo sapiens_hsa052170.48178793
69Proteoglycans in cancer_Homo sapiens_hsa052050.47556763
70Amoebiasis_Homo sapiens_hsa051460.47462422
71Nicotine addiction_Homo sapiens_hsa050330.46788846
72Vibrio cholerae infection_Homo sapiens_hsa051100.46159509
73Ether lipid metabolism_Homo sapiens_hsa005650.44577625
74Regulation of autophagy_Homo sapiens_hsa041400.44465065
75TGF-beta signaling pathway_Homo sapiens_hsa043500.43913409
76Metabolic pathways_Homo sapiens_hsa011000.42951566
77Serotonergic synapse_Homo sapiens_hsa047260.40769708
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40456107
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40255008
80Melanogenesis_Homo sapiens_hsa049160.39922744
81Choline metabolism in cancer_Homo sapiens_hsa052310.39509291
82Allograft rejection_Homo sapiens_hsa053300.39037203
83Ribosome_Homo sapiens_hsa030100.38466289
84Autoimmune thyroid disease_Homo sapiens_hsa053200.37706543
85Pentose phosphate pathway_Homo sapiens_hsa000300.37387702
86Collecting duct acid secretion_Homo sapiens_hsa049660.37239331
87Ovarian steroidogenesis_Homo sapiens_hsa049130.36135939
88Olfactory transduction_Homo sapiens_hsa047400.35964994
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35732025
90Graft-versus-host disease_Homo sapiens_hsa053320.35315350
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.33719967
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33444474
93Fatty acid elongation_Homo sapiens_hsa000620.33070249
94Hematopoietic cell lineage_Homo sapiens_hsa046400.32665789
95Vitamin digestion and absorption_Homo sapiens_hsa049770.32477505
96Phototransduction_Homo sapiens_hsa047440.32106907
97Bile secretion_Homo sapiens_hsa049760.29958652
98Calcium signaling pathway_Homo sapiens_hsa040200.29605870
99Glycerolipid metabolism_Homo sapiens_hsa005610.28849107
100Osteoclast differentiation_Homo sapiens_hsa043800.28524123
101cAMP signaling pathway_Homo sapiens_hsa040240.27799338
102Hedgehog signaling pathway_Homo sapiens_hsa043400.27064027
103Salmonella infection_Homo sapiens_hsa051320.26584375
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26283928
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.25974247
106Thyroid cancer_Homo sapiens_hsa052160.25883751
107PPAR signaling pathway_Homo sapiens_hsa033200.25165342
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23855812
109Cocaine addiction_Homo sapiens_hsa050300.22928383
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22898724
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21957830
112Circadian rhythm_Homo sapiens_hsa047100.21916352
113Starch and sucrose metabolism_Homo sapiens_hsa005000.21804257
114Pancreatic secretion_Homo sapiens_hsa049720.21714190
115TNF signaling pathway_Homo sapiens_hsa046680.21550772
116Rap1 signaling pathway_Homo sapiens_hsa040150.21181942
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21006933
118Mineral absorption_Homo sapiens_hsa049780.18688838
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18512209
120Fatty acid biosynthesis_Homo sapiens_hsa000610.18209883
121Sphingolipid metabolism_Homo sapiens_hsa006000.18161201
122Amphetamine addiction_Homo sapiens_hsa050310.18027789
123ABC transporters_Homo sapiens_hsa020100.17449729
124Tuberculosis_Homo sapiens_hsa051520.17443009
125Pyruvate metabolism_Homo sapiens_hsa006200.17143545
126Peroxisome_Homo sapiens_hsa041460.17007409
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16349674
128Long-term potentiation_Homo sapiens_hsa047200.15131823
129Dilated cardiomyopathy_Homo sapiens_hsa054140.14833462
130Wnt signaling pathway_Homo sapiens_hsa043100.14686682
131Insulin secretion_Homo sapiens_hsa049110.14449517
132Galactose metabolism_Homo sapiens_hsa000520.13873431
133Focal adhesion_Homo sapiens_hsa045100.13600473
134Cardiac muscle contraction_Homo sapiens_hsa042600.13073356
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.12738534
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12645434
137Viral myocarditis_Homo sapiens_hsa054160.12327075
138Arginine biosynthesis_Homo sapiens_hsa002200.12042257
139Legionellosis_Homo sapiens_hsa051340.11768666
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11767621
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.11735582
142Renin secretion_Homo sapiens_hsa049240.10803166
143Small cell lung cancer_Homo sapiens_hsa052220.09879552
144Lysosome_Homo sapiens_hsa041420.09862772
145Insulin resistance_Homo sapiens_hsa049310.09609537
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.09145121
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.09087007

Most similar genes based on co-expression Upload to Enrichr

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